Tai-Chi-Chuan on Differentiation and Maturation of Dendritic Cells - Full Text View

Sponsored by:	Mackay Memorial Hospital
Information provided by:	Mackay Memorial Hospital
ClinicalTrials.gov Identifier:	NCT00322959

Purpose

Tai-Chi-Chuan (TCC), a branch of traditional Chinese martial arts, has been widely practiced since the 17th century. Recent studies have shown that TCC can improve cardiorespiratory function, muscle strength, humoral and cellular immunity, metabolic response and mental control.

Cultured monocytes from blood or bone marrow can be triggered to differentiate to myeloid dendritic cells (DC). DCs are specialized leukocytes for presenting antigens to quiescent, naive, and memory T cells, and they play pivotal roles in the induction of cell-mediated as well as humoral immune responses in vivo. Mature DCs have a capacity for initiating immunity or tolerance, which depends on their activation state.

In this study we will investigate the effect of TCC on DC differentiation in the peripheral blood obtained from the healthy donors who take part with and without TCC exercise. The distribution of various DC sub-populations (myeloid DC and plasmacytoid cell) will be analyzed by detecting surface marker expression.

Condition
Immunity

U.S. FDA Resources

Study Type:	Observational
Study Design:	Case Control, Prospective
Official Title:	Effect of Tai-Chi-Chuan on Differentiation and Maturation of Human Dendritic Cells

Further study details as provided by Mackay Memorial Hospital:

Biospecimen Retention: None Retained

Biospecimen Description:

Enrollment:	20
Study Start Date:	August 2004
Study Completion Date:	November 2006
Primary Completion Date:	November 2006 (Final data collection date for primary outcome measure)

Show Detailed Description

Eligibility

Ages Eligible for Study:	25 Years to 65 Years
Genders Eligible for Study:	Both
Accepts Healthy Volunteers:	Yes
Sampling Method:	Non-Probability Sample

Study Population

TCC practitioner and Healthy subjects as controls

Criteria

Inclusion Criteria:

Yang TCC practitioner who keep practicing at least 3 times a week for more than 3 years
Healthy subjects as controls

Exclusion Criteria:

Who have a history of significant cardiovascular, pulmonary, and musculoskeletal diseases

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00322959

Locations

Taiwan
Department of Medical Research, Mackay Memorial Hospital
Taipei, Taiwan, 104

Sponsors and Collaborators

Mackay Memorial Hospital

Investigators

Principal Investigator:

Yu-Jen Chen, MD, PhD

Mackay Memorial Hospital

More Information

Publications:

Lee JJ, Liao HF, Yang YC, Liu CL, Chen YY, Lin CP, Chen YJ. Platonin modulates differentiation and maturation of human monocyte-derived dendritic cells. Int Immunopharmacol. 2006 Feb;6(2):287-93. Epub 2005 Sep 15.

Responsible Party:	Mackay Memorial Hospital ( Yu-Jen Chen )
Study ID Numbers:	MMH-I-S-056
Study First Received:	May 5, 2006
Last Updated:	September 19, 2008
ClinicalTrials.gov Identifier:	NCT00322959
Health Authority:	Taiwan: Institutional Review Board

Keywords provided by Mackay Memorial Hospital:

dendritic cells
Tai-Chi-Chuan

ClinicalTrials.gov processed this record on January 14, 2009