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Sponsored by: |
Royal Marsden NHS Foundation Trust |
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Information provided by: | Royal Marsden NHS Foundation Trust |
ClinicalTrials.gov Identifier: | NCT00825110 |
the principal research objective is to form a database of tissue samples from patients with colorectal (bowel) cancer. The tissue samples that will be used for this research will have already been taken for diagnostic or therapeutic reasons. We will also be asking for consent for a research blood sample. The database will be used to improve our understanding of the molecular genetics and gene expression patterns in colorectal cancer.
Condition |
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Colorectal Cancer |
Study Type: | Observational |
Study Design: | Cohort, Prospective |
Official Title: | SS-GCC1- Screening Study of Genetic Changes in Colorectal Cancer |
biospecimen includes formalin-fixed, paraffin embedded tissue, fresh frozen tissue and blood smaples
Estimated Enrollment: | 3750 |
Study Start Date: | November 2008 |
Estimated Study Completion Date: | June 2016 |
Estimated Primary Completion Date: | June 2016 (Final data collection date for primary outcome measure) |
Groups/Cohorts |
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No treatment
confirmed diagnosis of colorectal carcinoma
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All patients at the Royal Marsden with a diagnosis of colorectal cancer will be eligible to enter this study. This will include patients both with early and advanced disease, provided they give informed consent. They will give written consent to participate, to include consent for analysis of existing tumour tissue and consent for collection of demographic and clinicopathological data relating to their case and its future outcome, and consent for a blood sample to be taken for research purposes. Additionally, old samples of material surplus to clinical requirements may be collected without specific consent if there is no possibility that it would affect the patient's interest (eg the patient has died).
Ages Eligible for Study: | 18 Years and older |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | No |
Sampling Method: | Probability Sample |
All patients at the Royal Marsden with a diagnosis of colorectal cancer will be eligible to enter this study.
Adults who have a terminal illness
Inclusion Criteria:
Exclusion Criteria:
Contact: David Cunningham | 020 8661 3156 | jane.neil@rmh.nhs.uk |
Contact: Claire Saffery | 020 8661 3637 | claire.saffery@rmh.nhs.uk |
United Kingdom, Surrey | |
Royal Marsden NHS Foundation Trust | Recruiting |
Sutton, Surrey, United Kingdom, SM2 5PT | |
Contact: Prof Cunningham 020 8661 3165 jane.neil@rmh.nhs.uk | |
Contact: Claire Saffery 020 86613637 claire.saffery@rmh.nhs.uk | |
Principal Investigator: Prof Cunningham |
Principal Investigator: | Prof Cunningham, David | Royal Marsden NHS Foundation Trust |
Principal Investigator: | Prof Cunningham, David | Royal Marsden NHS Foundation Trust |
Responsible Party: | Royal Marsden NHS Foundation Trust ( Prof David Cunningham ) |
Study ID Numbers: | CCR3085 |
Study First Received: | January 16, 2009 |
Last Updated: | January 16, 2009 |
ClinicalTrials.gov Identifier: | NCT00825110 History of Changes |
Health Authority: | United Kingdom: Research Ethics Committee |
colorectal cancer gene expression biomarker genomic mismatch repair |
Digestive System Diseases Digestive System Neoplasms Gastrointestinal Diseases Colonic Diseases Gastrointestinal Neoplasms |
Intestinal Diseases Rectal Diseases Intestinal Neoplasms Colorectal Neoplasms |
Neoplasms Digestive System Diseases Neoplasms by Site Digestive System Neoplasms Gastrointestinal Diseases Colonic Diseases |
Gastrointestinal Neoplasms Intestinal Diseases Rectal Diseases Intestinal Neoplasms Colorectal Neoplasms |