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Human Genetic Analysis ResourceON THIS PAGE: SEE ALSO: Human Genetic Analysis Resource
Research EmphasisThe Human Genetic Analysis Resource (H.G.A.R.) is developing a user-friendly software package, S.A.G.E. (Statistical Analysis for Genetic Epidemiology), that can be used to analyze family data to determine whether the variability of a trait, either quantitative or qualitative, is significantly due to Mendelian segregation at a single genetic locus; whether there is an association between a quantitative or qualitative trait and a known polymorphic genetic marker; and whether there are genetic loci linked to a known genetic marker that underlie variability in a trait. Current ResearchCurrent research is focused on the theoretical development of statistical methods for the analysis of family data, especially to detect and identify genetic components that underlie disease susceptibility; the incorporation of these methods into appropriate computer programs to make the programs generally available to other human geneticists and genetic epidemiologists in a well-documented and user-friendly form; the evaluation of the validity, power, and robustness of the statistical procedures, especially to differentiate genetic causes from alternative environmental causes for familial aggregation; and the application of methods and programs in collaborative projects to identify single genes that play roles in the etiology of various diseases. Resource CapabilitiesSoftwareComputer: The Human Genetic Analysis Resource has specifically purchased the following computer equipment for developing genetic analysis software and performing genetic analyses: Microway UP2000 Dual 667MHz Alpha Server with 1gigabytes (GB) of random access memory (RAM) and 225 GB of online disk space; 5 Node Dell SC1425 SGE Linux Cluster with 20 GB of distributed RAM; 12 node Dell PE2650, PE6650 OpenMosix cluster, with 15 GB of distributed RAM and 1.2 tetrabytes (TB) of online disk space; Windows 2003 File Server with 1 GB of RAM; 5.25 TB storage area network to accommodate the storage needs of the resource; EMC Legato Networker server with an attached 10-tape SDLT autoloader library; two Linux light weight directory access protocol servers for authentication purposes; Intel Linux network attached storage server with 1 GB of RAM; Dell PE6450 Server with 3 GB of RAM and 64 GB of online disk space; HP Itanium workstation with 1 GB of RAM; Apple G5 Workstation with 2 GB of RAM and 80 GB of online disk space; Microway Durango Alpha Class workstation with 512 MB of RAM and 8 GB of online disk space; Sun Workstation with 1 GB of RAM and 8 GB of online disk space; Dell SC1425 Linux Server with 4 GB of RAM; Dell PE1850 Linux Server with 2 GB of RAM; Sun E450 server with 3 GB of RAM and 80 GB of online disk space; Sun E3500 with 1 GB RAM and 18 GB of disk space; and 15 Intel workstations that are used in the development of S.A.G.E. Several printers are available for usage including 5 HP Laserjets, a RICOH Color Laser printer. Media handling capabilities include compact disk rewritable/digital video disc rewritable Rom, digital linear tape, and super digital linear tape. All computers and printers are networked on a 1000Base T Ethernet connection to CWRUnet. These computer facilities are in addition to the departmental computer facilities described in publication 4 (see below). H.G.A.R. is continually developing the computer package S.A.G.E. and collaborations both nationally and internationally. Publications
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National Institutes of Health (NIH) Bethesda, Maryland 20892 |
Department of Health and Human Services |