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Sponsored by: |
University of California, San Francisco |
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Information provided by: | University of California, San Francisco |
ClinicalTrials.gov Identifier: | NCT00187668 |
Collect DNA from well-characterized healthy volunteers. DNA will be used to identify and determine allele frequencies of genetic variants in membrane transporters and other genes relevant to human disease or drug response, including drug metabolizing enzymes, collagen, race/ethnicity, neurovascular disease, asthma/allergy/lung disease, and cardiovascular disease. This phase of the study will serve as the hypothesis-generating phase for future studies by identifying genetic variants and determining allele frequencies among an ethnically diverse cohort of healthy volunteers. Future investigations (separate IRB applications) will attempt to correlate genotypes to phenotypes among this cohort of volunteers. The allele identification and frequency data from this group of healthy volunteers will also be used to design association studies in relevant disease populations.
Determine if identified sequence variants are associated with gain or loss of in vitro biologic function using lymphocytes obtained from patients.
Condition |
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Healthy Volunteers |
Study Type: | Observational |
Study Design: | Screening, Cross-Sectional, Convenience Sample, Prospective Study |
Official Title: | Study Of PHarmacogenetics in Ethnically Diverse Populations (SOPHIE Study) |
Ages Eligible for Study: | 18 Years to 40 Years |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | Yes |
Inclusion Criteria:
Exclusion Criteria:
United States, California | |
San Francisco General Hopsital | Recruiting |
San Francisco, California, United States, 94143 | |
Contact: Richard M Castro, MD 415-722-8758 castror@pharmacy.ucsf.edu |
Principal Investigator: | Kathleen M Giacomini, PhD | Univeristy of California, San Francisco |
Study ID Numbers: | 701, GM 61390 |
Study First Received: | September 13, 2005 |
Last Updated: | September 13, 2005 |
ClinicalTrials.gov Identifier: | NCT00187668 |
Health Authority: | United States: Institutional Review Board |
Healthy |