Voltage-gated calcium channels control numerous critical cellular functions in neuronal and non-neuronal cells. They are targets of numerous therapeutic agents, ethyl alcohol, arthropod and mollusk toxins and some environmentally relevant toxic metals. Certain rare diseases including Lambert-Eaton Myasthenic Syndrome (LEMS), hereditary ataxias and Familial Hemiplegic Migraine may also be the result of altered calcium channel function. Therefore, it is important to define and identify what is currently known about voltage-gated calcium channels, the role they play in certain rare disorders, and the role that xenobiotics play in their dysfunction.
This workshop will bring together neurobiologists, neurotoxicologists and neurologists to explore the state of the science/medicine in this field with the ultimate goal of identifying research gaps, both basic and clinical.
Functional Effects of Mutations in L-Type Voltage-sensitive Ca2+ channels in Hypokalemic Periodic Paralysis
Philip Lory
Centre National de la Recherche Scientifique
a1A Mutant Mouse Models of Familial Hemiplegic Migraine
Danielle Pietrobon
University of Padova
Functional Effects of Ca2+ Channel Subunit Mutations: Roles in Epilepsy
Michelle Rees
University College of London
Poster Session/Reception
Tuesday, December 7, 7 - 9pm
Doubletree Guest Suites Hotel
Abstract deadline is November 1, 1999
Please send abstracts to Dr. Annette Kirshner at the address listed under Registration.
Registration
No registration fee will be assessed for attendance. However, space is limited, thus we request that attendees register in advance to reserve a space. To register or submit a poster, please contact:
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