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Sponsored by: |
State University of New York - Upstate Medical University |
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Information provided by: | State University of New York - Upstate Medical University |
ClinicalTrials.gov Identifier: | NCT00615485 |
Specific subgroups of children who survive treatment for childhood malignancies have been shown to develop relative osteopenia following chemotherapy and are felt to be at risk for developing osteoporosis later in life due to their inability to reach peak bone mass during childhood. Based upon an earlier study in our department, we reported conclusive evidence that approximately half of survivors of pediatric solid malignancies are at risk for these problems. However, the proportion of patients in our population that showed osteopenia/osteoporosis was lower than that in other similar cross-sectional studies in solid tumors such as osteosarcoma. The main difference between our report and the osteosarcoma study was duration of follow-up, with ours being shorter. Longer follow-up may prove that a larger proportion of our patients are affected. The purpose is to perform a longitudinal follow-up study of bone mineral density using dual-energy X-ray absorptiometry (DXA) in adult survivors of solid pediatric tumors that were previously studied as subjects in our original cross-sectional study. The primary hypothesis is that the proportion of pediatric solid cancer survivors with significantly lower bone mineral density (BMD) compared to established age group controls will be increased with the additional time that has elapsed since the original study despite the fact that the patients are young and would not normally be expected to have osteopenia/osteoporosis at this age.
Condition |
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Osteoporosis |
Study Type: | Observational |
Official Title: | Longitudinal Study of Bone Mineral Density in Survivors of Solid Pediatric Cancers |
bone specific alkaline phosphatase n-telopeptide
Estimated Enrollment: | 38 |
Study Start Date: | January 2006 |
Estimated Primary Completion Date: | January 2009 (Final data collection date for primary outcome measure) |
Ages Eligible for Study: | 7 Years to 40 Years |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | No |
Sampling Method: | Non-Probability Sample |
The 38 patients from the SUNY Upstate Medical Center (Syracuse, NY) Pediatric Oncology Long-term Survivor Clinic who were subjects in the original Georg Fund supported study will comprise the patient population if they are locatable and willing to participate. Patients must be less than 40 years of age to participate.
Inclusion criteria:
Exclusion criteria:
United States, New York | |
SUNY Upstate Medical University | |
Syracuse, New York, United States, 13202 |
Principal Investigator: | Timothy A Damron, MD | SU |
Responsible Party: | SUNY Upstate Medical University Department of Orthopedic Surgery ( Timothy A. Damron, MD ) |
Study ID Numbers: | Solid Pediatric Cancers, Joseph C. Georg Fund |
Study First Received: | February 1, 2008 |
Last Updated: | December 1, 2008 |
ClinicalTrials.gov Identifier: | NCT00615485 |
Health Authority: | United States: Institutional Review Board |
Examine the risk of osteoporosis in survivors of solid pediatric cancers |
Musculoskeletal Diseases Osteoporosis Bone Diseases, Metabolic Bone Diseases |