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| Sponsors and Collaborators: |
University of Aarhus Aarhus University Hospital |
|---|---|
| Information provided by: | University of Aarhus |
| ClinicalTrials.gov Identifier: | NCT00614900 |
Purpose
The prevalence of an increased pulmonary blood pressure amongst patients with chronic obstructive pulmonary disease (COPD)is unclear. So is the impact of abnormal pulmonary blood pressure on symptoms. The aim of this study is to determine the prevalence of an increased pulmonary blood pressure in 200 patients with COPD. Furthermore we will investigate if lung function test results and blood tests can predict an increased pulmonary blood pressure, and explore whether COPD patients with a high pulmonary blood pressure have more symptoms that their co-patients.
| Condition |
|---|
|
COPD Pulmonary Hypertension |
| Study Type: | Observational |
| Study Design: | Cross-Sectional |
| Official Title: | Prevalence and Influence of Pulmonary Hypertension in COPD Patients |
Blood samples
| Estimated Enrollment: | 200 |
| Study Start Date: | March 2008 |
| Estimated Study Completion Date: | December 2010 |
| Estimated Primary Completion Date: | December 2008 (Final data collection date for primary outcome measure) |
The prevalence of pulmonary hypertension in patients with chronic obstuctive pulmonary disease (COPD) is unclear. The presence of an abnormally increased pulmonary blood pressure worsens the prognosis of COPD, but the patients are not currently diagnosed or treated for pulmonary hypertension. The aim of this study is to determine the prevalence of pulmonary hypertension in 200 patients with COPD and explore whether it worsens functional capacity and symptoms. Furthermore we will look into whether blood gas values, NT-proBNP, CRP and lung function test result can predict which patients are at risk of having pulmonary hypertension.
Methods: All patients will be screened by eccocardiography. Those with signs of pulmonary hypertension will be admitted to right heart catheterization for direct measurements of pulmonary haemodynamics.
All patients wil perform a 6 minutes walk test and spirometry. Blood levels of NT-proBNP and CRP will be measured. Life quality by the st. George Questionnaire and contacts to the healt care system is also assesed. Differences in these parameters are analysed among patients with no, moderate or severe pulmonary hypertension.
Eligibility| Genders Eligible for Study: | Both |
| Accepts Healthy Volunteers: | No |
| Sampling Method: | Non-Probability Sample |
All patients have been admitted to hospital with an exacerbation in COPD in 2006.
Inclusion Criteria:
Exclusion Criteria:
Contacts and Locations| Contact: Charlotte U. Andersen, MD | +45 89 42 17 10 | cua@farm.au.dk |
| Contact: Ole Hilberg, MD, Dr.med. | +45 89 49 21 19 | ohilb@as.aaa.dk |
| Denmark | |
| Department of pulmonary diseases, Aarhus Sygehus | Recruiting |
| Århus, Denmark, 8000 | |
| Study Director: | Ole Hilberg, Md, Dr.med. | Aarhus Universitetshospital, Aarhus Sygehus |
More Information
| Responsible Party: | Aarhus University ( M.D. Charlotte U. Andersen ) |
| Study ID Numbers: | PreKPH-08, jnr 2007-0206 |
| Study First Received: | January 31, 2008 |
| Last Updated: | January 9, 2009 |
| ClinicalTrials.gov Identifier: | NCT00614900 |
| Health Authority: | Denmark: Danish Dataprotection Agency; Denmark: Ethics Committee |
|
COPD pulmonary hypertension NT-proBNP 6 minutes walk test |
|
Lung Diseases, Obstructive Respiratory Tract Diseases Hypertension, Pulmonary Lung Diseases |
Vascular Diseases Pulmonary Disease, Chronic Obstructive Hypertension |
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Cardiovascular Diseases |
