Antiemetic Effect of the Addition of Ondansetron to the Morphine Solution in Patient-Controlled Analgesia (PCA)

This study has been completed.

Sponsored by:	Khon Kaen University
Information provided by:	Khon Kaen University
ClinicalTrials.gov Identifier:	NCT00199329

Purpose

PCA morphine always introduces nausea and vomiting during the postoperative period. Ondansetron can reduce PONV (postoperative nausea vomiting). We, the researchers at Khon Kaen University, are trying to add ondansetron in PCA morphine. Patients receive a small dose of ondansetron when they request morphine.

Condition	Intervention
Postoperative Nausea and Vomiting	Drug: ondansetron adding in PCA

MedlinePlus related topics: Nausea and Vomiting

Drug Information available for: Ondansetron Ondansetron hydrochloride

U.S. FDA Resources

Study Type:	Interventional
Study Design:	Treatment, Randomized, Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Placebo Control, Parallel Assignment, Efficacy Study

Further study details as provided by Khon Kaen University:

Primary Outcome Measures:

PONV [ Time Frame: 24 hr ]

Enrollment:	160
Study Start Date:	January 2005

Eligibility

Ages Eligible for Study:	15 Years to 60 Years
Genders Eligible for Study:	Both
Accepts Healthy Volunteers:	No

Criteria

Inclusion Criteria:

Age between 15-60 years old

Exclusion Criteria:

History of motion sickness, smoking

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00199329

Locations

Thailand, Khon Kaen
Khon Kaen university, Srinagarind Hospital
Muang, Khon Kaen, Thailand, 40002

Sponsors and Collaborators

Khon Kaen University

Investigators

Study Director:

Polpun Boonmak, MD

lecturer in Khon Kaen University

More Information

Study ID Numbers:	I48027
Study First Received:	September 14, 2005
Last Updated:	October 31, 2007
ClinicalTrials.gov Identifier:	NCT00199329
Health Authority:	Thailand: Food and Drug Administration

Keywords provided by Khon Kaen University:

ondansetron
PCA

Study placed in the following topic categories:

Morphine
Signs and Symptoms
Postoperative Nausea and Vomiting
Vomiting
Signs and Symptoms, Digestive

Postoperative Complications
Nausea
Ondansetron
Serotonin

Additional relevant MeSH terms:

Neurotransmitter Agents
Tranquilizing Agents
Molecular Mechanisms of Pharmacological Action
Physiological Effects of Drugs
Psychotropic Drugs
Gastrointestinal Agents
Central Nervous System Depressants
Antiemetics
Antipsychotic Agents
Pharmacologic Actions

Serotonin Antagonists
Pathologic Processes
Serotonin Agents
Autonomic Agents
Therapeutic Uses
Antipruritics
Anti-Anxiety Agents
Peripheral Nervous System Agents
Central Nervous System Agents
Dermatologic Agents

ClinicalTrials.gov processed this record on January 15, 2009