| Agent Name |
Vanadium pentoxide |
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| CAS Number |
1314-62-1 |
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| Formula |
O5-V2 |
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| Major Category |
Metals |
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| Synonyms |
Divanadium pentoxide; Vanadic anhydride; Vanadium oxide; Vanadium pentaoxide; [NIOSH] UN2862 |
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| Category |
Metals, Inorganic Compounds |
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| Description |
Yellow-orange powder or dark-gray, odorless flakes dispersed in air; [NIOSH] |
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| Sources/Uses |
Vanadium has been measured in fuel oil at 250 to 400 ppm and in Bessemer slag at 10 to 15% of the weight of the total ash. [ACGIH] Flu ash from oil burning furnaces may contain more than 50% vanadium pentoxide; [ILO Encyclo, Vol. 3, p. 63.1-63.68] Vanadium exposure can also occur in workers cleaning coal furnaces, mining, and producing ferrovanadium. Vanadium is used as a polymer catalyst, dye mordant, and ceramic colorant. [LaDou, p. 434] |
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| Comments |
Chronic bronchitis has been described in boiler cleaners exposed to vanadium pentoxide. [ACGIH] Green tongue has been reported after local deposition, but it is not a sign of systemic poisoning. [Rosenstock, p. 988] |
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| Reference Link |
Pulmonary function in workers exposed to low levels of fuel-oil ash |
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| Exposure Assessment |
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| BEI |
Vanadium in urine = 50 ug/g creatinine; sample at end of shift at end of workweek; |
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| Skin Designation (ACGIH) |
No |
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| TLV (ACGIH) |
0.05 mg/m3, respirable dust or fume |
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| PEL (OSHA) | Ceiling(OSHA) = 0.5 mg/m3 ( respirable dust), 0.1 mg/m3 (fume) |
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| IDLH (NIOSH) |
35 mg/m3, as V |
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| Excerpts from Documentation for IDLHs |
Human data: Respiratory irritation following exposures to V2O5 ranging from 1 to 48 mg V/m3 has been described in workers [Sjoberg 1955]. Vanadium intoxication (i.e., rhinorrhea, sneezing, lacrimation, and sore throat) has been reported in workers exposed to concentrations of V2O5 during the workshift ranging from 10 to 33 mg/m3 [Williams 1952]. Concentrations of V2O5 exceeding 56 mg V/m3 have resulted in local respiratory effects [Vintinner et al. 1955]. Other workers exposed intermittently to 56 mg V/m3 showed no evidence of intoxication [McTurk et al. 1956]. |
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| Lethal Concentration |
LC50 (rats) = 126 mg/m3/6H |
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| Explanatory Notes |
See 2008 Notice of Intended Changes. [ACGIH] |
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| Half Life |
Animal studies: 40% of absorbed dose eliminated in urine within 3 days; [TDR, p. 1212] |
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| Reference Link |
ATSDR - ToxFAQs - Vanadium |
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| Adverse Effects |
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| Chronic Bronchitis |
Yes |
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| Links to Other NLM Databases |
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| Health Studies |
Human Health Effects from Hazardous Substances Data Bank: VANADIUM PENTOXIDE
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