This study will examine over the long-term the progress of patients with neurofibromatosis Type 2 (NF2), a condition associated with tumors of the nerves, brain and spinal cord. It will study patients' tumors to learn how fast they can grow and if certain factors might affect their growth. It will also examine the effects of the tumors on patients' abilities to carry out activities of daily living.

People between 8 and 75 years of age with NF2 may be eligible for this study. Participants undergo the following procedures:

Initial evaluation, including hearing, eye and balance testing, gait (walk) testing, magnetic resonance imaging (MRI) scans of the brain and spine, blood tests, and physical and neurological examinations.

MRI scans of the brain and spine every 6 months to follow the size and number of tumors.

Physical and neurological examinations and blood tests every 6 months.

Auditory tests every 12 months. These tests evaluate middle and inner ear function and the patient's ability to hear tones at different frequencies and to hear words at different volumes. The subject responds to tones and words that are delivered through earphones.

Eye examination every 1 to 2 years.

Gait testing every 12 months if a spinal cord tumor causes problems with sensation or muscle control in the arms and legs - Subjects' joints are measured while they walk across a room several times as scientific cameras record their movements.

Vestibular testing if the patient experiences changes in balance or undergoes treatment for vestibular schwannoma (a tumor that develops on the hearing and balance nerves). These tests check the function of various components of the balance system (eyes, inner ear, or leg and body sensation and muscles). They include:

• Videoelectronystagmogram - Tracks subjects' eye movements while they follow moving red lights with their eyes.
• Vestibular evoked myogenic potential - Assesses subjects' neck muscle movements in response to noise.
• Posturography - Determines which parts of the balance system the subject relies on most. Subjects stand on a platform and try to maintain their balance while changes are made to the platform and the environment.
• Rotary chair test - Subjects' eye movements are monitored as they follow red spots and strips of light with their eyes while seated in a rotary chair that turns side to side at several speeds.