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Sponsored by: |
Tel-Aviv Sourasky Medical Center |
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Information provided by: | Tel-Aviv Sourasky Medical Center |
ClinicalTrials.gov Identifier: | NCT00598052 |
Recent studies have established the reliability, validity and time course of the cannabis withdrawal syndrome. This study will investigate the effects of combined treatment of Escitalopram with cognitive-behavior therapy in alleviating the symptoms of the marijuana withdrawal syndrome in regular chronic users of marijuana. We predict that combined pharmacological treatment and cognitive-behavior therapy will help patients to abstain from using using marijuana and it will alleviate their marijuana withdrawal symptoms.
Condition | Intervention |
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Marijuana Dependence |
Drug: Escitalopram |
Study Type: | Interventional |
Study Design: | Treatment, Randomized, Double Blind (Caregiver, Investigator, Outcomes Assessor), Placebo Control, Parallel Assignment, Efficacy Study |
Official Title: | Treatment of Marijuana Withdrawal Syndrome Using Escitalopram and Cognitive-Behavior Therapy- a Double-Blind Placebo-Controlled Study |
Estimated Enrollment: | 40 |
Study Start Date: | December 2007 |
Estimated Study Completion Date: | October 2008 |
Estimated Primary Completion Date: | October 2008 (Final data collection date for primary outcome measure) |
Arms | Assigned Interventions |
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A: Active Comparator
Escitalopram + cognitive-behavior treatment
|
Drug: Escitalopram
10mg/day
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B: Placebo Comparator
Placebo + cognitive-behavior therapy
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Drug: Escitalopram
10mg/day
|
Recent studies have established the reliability, validity and time course of the cannabis withdrawal syndrome characterized by symptoms of anxiety, irritability, negative mood, physical symptoms and decreased appetite. This study will investigate the effects of combined treatment of Escitalopram with cognitive-behavior therapy in alleviating the symptoms of the marijuana withdrawal syndrome in regular chronic users of marijuana. 40 patients will be blindly randomized to either active or placebo escitalopram 10mg/day, for 12 weeks followed bt 12 weeks of follow-up.
Inclusion criteria include:
Exclusion criteria include:
Outcome measures include:
Ages Eligible for Study: | 20 Years to 45 Years |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | Yes |
Inclusion Criteria:
Exclusion Criteria:
Contact: Aviv M Weinstein, Ph.D | 97236973685 | avivmw@tasmc.health.gov.il |
Contact: Eti Tal, B.A | 97236973685 | etital10@walla.com |
Israel | |
Sourasky Medical Center | Recruiting |
Tel Aviv, Israel, 64239 | |
Contact: Irit Ben-Avi, Ph.D 97236973685 iritbe@gmail.com | |
Contact: Eti Tal, B.A 97236973685 etital10@walla.com | |
Principal Investigator: Aviv M Weinstein, Ph.D | |
Principal Investigator: Miki Bloch, M.D |
Principal Investigator: | Miki Bloch, M.D | Sourasky Medical center, Tel Aviv |
Principal Investigator: | Aviv M Weinstein, Ph.D | Sourasky Medical Center Tel Aviv, Israel |
Responsible Party: | Sourasky Medical center ( Dr. Miki Bloch ) |
Study ID Numbers: | TASMC-7.1.08-CTIL, Sponsored by IADA |
Study First Received: | January 9, 2008 |
Last Updated: | March 30, 2008 |
ClinicalTrials.gov Identifier: | NCT00598052 |
Health Authority: | Israel: Ministry of Health |
Marijuana dependence withdrawal Escitalopram |
Substance Withdrawal Syndrome Mental Disorders Substance-Related Disorders Disorders of Environmental Origin |
Dexetimide Citalopram Marijuana Abuse Serotonin |
Parasympatholytics Neurotransmitter Uptake Inhibitors Neurotransmitter Agents Molecular Mechanisms of Pharmacological Action Cholinergic Antagonists Anti-Dyskinesia Agents Physiological Effects of Drugs Psychotropic Drugs Antiparkinson Agents Cholinergic Agents |
Serotonin Uptake Inhibitors Pharmacologic Actions Muscarinic Antagonists Serotonin Agents Autonomic Agents Therapeutic Uses Peripheral Nervous System Agents Antidepressive Agents, Second-Generation Central Nervous System Agents Antidepressive Agents |