Biochemical Marker to Predict the Recurrence of Atrial Fibrillation After Surgical Maze Procedure

This study is currently recruiting participants.

Verified by Samsung Medical Center, February 2005

Sponsored by:	Samsung Medical Center
Information provided by:	Samsung Medical Center
ClinicalTrials.gov Identifier:	NCT00542659

Purpose

The role of plasma NT-proBNP, hsCRP, TIMP-1(Tissue inhibitors of MetalloProteinase-1),TGF-b, MMP-3(Matrix MetalloProteinase-3), and pro-MMP-1 in predicting the recurrence of AF after surgical Maze procedure.

The association of expression of CTGF, TGF-b, BNP, ANP, collagen-1, and collagen-3 in LA with the recurrence of AF after surgical Maze procedure.

Condition
Atrial Fibrillation

Genetics Home Reference related topics: Brugada syndrome familial atrial fibrillation short QT syndrome

Drug Information available for: Proline

U.S. FDA Resources

Study Type:	Observational
Study Design:	Prospective
Official Title:	Plasma ANP and NT-Pro-BNP, Atrial Anatomical Change May Determine the Outcome of Maze Operation

Further study details as provided by Samsung Medical Center:

Primary Outcome Measures:

AF recurrence [ Time Frame: year ]

Biospecimen Retention: Samples Without DNA

Biospecimen Description:

plasma mRNA

Study Start Date:	February 2005
Estimated Study Completion Date:	December 2007

Eligibility

Ages Eligible for Study:	30 Years to 75 Years
Genders Eligible for Study:	Both
Accepts Healthy Volunteers:	No

Criteria

Inclusion Criteria:

The patients who have valvular heart disease with atrial fibrillation and are scheduled for operation

Exclusion Criteria:

Coronary heart disease
Congestive heart failure

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00542659

Contacts

Contact: Young Keun On, MD

82-2-3410-3420

yk.on@samsung.com

Locations

Korea, Republic of
Samsung Medical Center	Recruiting
Seoul, Korea, Republic of, 135-710
Contact: Young Keun On, MD

Sponsors and Collaborators

Samsung Medical Center

Investigators

Principal Investigator:

Young Keun On, MD

Samsung Medical Center

More Information

Study ID Numbers:	AFMaze
Study First Received:	October 10, 2007
Last Updated:	October 10, 2007
ClinicalTrials.gov Identifier:	NCT00542659
Health Authority:	United States: Institutional Review Board

Keywords provided by Samsung Medical Center:

Atrial fibrillation
Maze procedure

Study placed in the following topic categories:

Heart Diseases
Atrial Fibrillation
Recurrence
Arrhythmias, Cardiac

Additional relevant MeSH terms:

Pathologic Processes
Cardiovascular Diseases

ClinicalTrials.gov processed this record on January 15, 2009