| | This journal provides immediate access to some articles. Commentaries Seeking new meiotic genes Marco Barchi and Maria Jasin PMCID: PMC307557 Another twist in the transforming growth factor β-induced cell-cycle arrest chronicle Catherine Denicourt and Steven F. Dowdy PMCID: PMC307558 Costimulatory signals controlling regulatory T cells Joerg Ermann and C. Garrison Fathman PMCID: PMC307559 Physical Sciences Applied Physical Sciences Imaging linear birefringence and dichroism in cerebral amyloid pathologies Lee-Way Jin, Kacey A. Claborn, Miki Kurimoto, Morten A. Geday, Izumi Maezawa, Faranak Sohraby, Marcus Estrada, Werner Kaminksy, and Bart Kahr PMCID: PMC307560 Controlling system dimension: A class of real systems that obey the Kaplan–Yorke conjecture J. M. Nichols, M. D. Todd, M. Seaver, S. T. Trickey, L. M. Pecora, and L. Moniz PMCID: PMC307561 Chemistry The low-spin heme of cytochrome c oxidase as the driving element of the proton-pumping process Tomitake Tsukihara, Kunitoshi Shimokata, Yukie Katayama, Hideo Shimada, Kazumasa Muramoto, Hiroshi Aoyama, Masao Mochizuki, Kyoko Shinzawa-Itoh, Eiki Yamashita, Min Yao, Yuzuru Ishimura, and Shinya Yoshikawa PMCID: PMC307562 Mathematics Prediction and statistics of pseudoknots in RNA structures using exactly clustered stochastic simulations A. Xayaphoummine, T. Bucher, F. Thalmann, and H. Isambert PMCID: PMC307563 A pointwise estimate for fractionary derivatives with applications to partial differential equations Antonio Córdoba and Diego Córdoba PMCID: PMC307564 Physics Polariton lasing vs. photon lasing in a semiconductor microcavity Hui Deng, Gregor Weihs, David Snoke, Jacqueline Bloch, and Yoshihisa Yamamoto PMCID: PMC307565 A macroscopic scale model of bacterial flagellar bundling MunJu Kim, James C. Bird, Annemarie J. Van Parys, Kenneth S. Breuer, and Thomas R. Powers PMCID: PMC307593 Statistics Markov chain Monte Carlo without likelihoods Paul Marjoram, John Molitor, Vincent Plagnol, and Simon Tavaré PMCID: PMC307566 Biological Sciences Agricultural Sciences Altered starch structure is associated with endosperm modification in Quality Protein Maize Bryan C. Gibbon, Xuelu Wang, and Brian A. Larkins PMCID: PMC307567 Anthropology Encephalization and allometric trajectories in the genus Homo: Evidence from the Neandertal and modern lineages Emiliano Bruner, Giorgio Manzi, and Juan Luis Arsuaga PMCID: PMC307568 Applied Biological Sciences Climatic suitability for malaria transmission in Africa, 1911–1995 Jennifer Small, Scott J. Goetz, and Simon I. Hay PMCID: PMC307569 Cellular and nerve regeneration within a biosynthetic extracellular matrix for corneal transplantation Fengfu Li, David Carlsson, Chris Lohmann, Erik Suuronen, Sandy Vascotto, Karin Kobuch, Heather Sheardown, Rejean Munger, Masatsugu Nakamura, and May Griffith PMCID: PMC307570 Phylogenetic and biochemical evidence for sterol synthesis in the bacterium Gemmata obscuriglobus Ann Pearson, Meytal Budin, and Jochen J. Brocks PMCID: PMC307571 Ligand selectivity by seeking hydrophobicity in thyroid hormone receptor Sabine Borngraeber, Mary-Jane Budny, Grazia Chiellini, Suzana T. Cunha-Lima, Marie Togashi, Paul Webb, John D. Baxter, Thomas S. Scanlan, and Robert J. Fletterick PMCID: PMC307572 Protection of Cftr knockout mice from acute lung infection by a helper-dependent adenoviral vector expressing Cftr in airway epithelia David R. Koehler, Umadevi Sajjan, Yu-Hua Chow, Bernard Martin, Geraldine Kent, A. Keith Tanswell, Colin McKerlie, Janet F. Forstner, and Jim Hu PMCID: PMC307573 l-Lysine acts like a partial serotonin receptor 4 antagonist and inhibits serotonin-mediated intestinal pathologies and anxiety in rats Miro Smriga and Kunio Torii PMCID: PMC307574 Biochemistry Crystal structures that suggest late development of genetic code components for differentiating aromatic side chains Xiang-Lei Yang, Francella J. Otero, Robert J. Skene, Duncan E. McRee, Paul Schimmel, and Lluís Ribas de Pouplana PMCID: PMC307575 Genetic, biochemical, and morphological evidence for the involvement of N-glycosylation in biosynthesis of the cell wall β1,6-glucan of Saccharomyces cerevisiae Manasi Chavan, Tadashi Suzuki, Magdalena Rekowicz, and William Lennarz PMCID: PMC307576 MSH2 and ATR form a signaling module and regulate two branches of the damage response to DNA methylation Yi Wang and Jun Qin PMCID: PMC307577 An oxocarbenium-ion intermediate of a ribozyme reaction indicated by kinetic isotope effects Peter J. Unrau and David P. Bartel PMCID: PMC307578 Structure of Mth11/Mth Rpp29, an essential protein subunit of archaeal and eukaryotic RNase P William P. Boomershine, Craig A. McElroy, Hsin-Yue Tsai, Ross C. Wilson, Venkat Gopalan, and Mark P. Foster PMCID: PMC307579 Rapid protein fold determination using unassigned NMR data Jens Meiler and David Baker PMCID: PMC307580 Divergent tRNA-like element supports initiation, elongation, and termination of protein biosynthesis Eric Jan, Terri Goss Kinzy, and Peter Sarnow PMCID: PMC307581 A tenascin-C aptamer identified by tumor cell SELEX: Systematic evolution of ligands by exponential enrichment Dion A. Daniels, Hang Chen, Brian J. Hicke, Kristine M. Swiderek, and Larry Gold PMCID: PMC307582 Trans-editing of mischarged tRNAs Ivan Ahel, Dragana Korencic, Michael Ibba, and Dieter Söll PMCID: PMC307583 Genome evolution reveals biochemical networks and functional modules Christian von Mering, Evgeny M. Zdobnov, Sophia Tsoka, Francesca D. Ciccarelli, Jose B. Pereira-Leal, Christos A. Ouzounis, and Peer Bork PMCID: PMC307584 An efficient proteomics method to identify the cellular targets of protein kinase inhibitors Klaus Godl, Josef Wissing, Alexander Kurtenbach, Peter Habenberger, Stephanie Blencke, Heidrun Gutbrod, Kostadinos Salassidis, Matthias Stein-Gerlach, Andrea Missio, Matt Cotten, and Henrik Daub PMCID: PMC307585 Generating a synthetic genome by whole genome assembly: ![[var phi]](corehtml/pmc/pmcents/x03C6.gif) X174 bacteriophage from synthetic oligonucleotides Hamilton O. Smith, Clyde A. Hutchison, III, Cynthia Pfannkoch, and J. Craig Venter PMCID: PMC307586 Autoubiquitylation of the V(D)J recombinase protein RAG1 Jessica M. Jones and Martin Gellert PMCID: PMC307587 A general strategy for target-promoted alkylation in biological systems Qibing Zhou and Steven E. Rokita PMCID: PMC307588 A role in vacuolar arginine transport for yeast Btn1p and for human CLN3, the protein defective in Batten disease Yoojin Kim, Denia Ramirez-Montealegre, and David A. Pearce PMCID: PMC307589 Myoglobin forms amyloid fibrils by association of unfolded polypeptide segments Marcus Fändrich, Vincent Forge, Katrin Buder, Marlis Kittler, Christopher M. Dobson, and Stephan Diekmann PMCID: PMC307590 Donation of catalytic residues to RNA polymerase active center by transcription factor Gre Ekaterina Sosunova, Vasily Sosunov, Maxim Kozlov, Vadim Nikiforov, Alex Goldfarb, and Arkady Mustaev PMCID: PMC307591 Biophysics Prediction and statistics of pseudoknots in RNA structures using exactly clustered stochastic simulations A. Xayaphoummine, T. Bucher, F. Thalmann, and H. Isambert PMCID: PMC307563 Conformations and dynamics of Ets-1 ETS domain–DNA complexes Swarnalatha Y. Reddy, Satoshi Obika, and Thomas C. Bruice PMCID: PMC307592 A macroscopic scale model of bacterial flagellar bundling MunJu Kim, James C. Bird, Annemarie J. Van Parys, Kenneth S. Breuer, and Thomas R. Powers PMCID: PMC307593 Ultrafast folding of α3D: A de novo designed three-helix bundle protein Yongjin Zhu, Darwin O. V. Alonso, Kosuke Maki, Cheng-Yen Huang, Steven J. Lahr, Valerie Daggett, Heinrich Roder, William F. DeGrado, and Feng Gai PMCID: PMC307594 Probing protein oligomerization in living cells with fluorescence fluctuation spectroscopy Yan Chen, Li-Na Wei, and Joachim D. Müller PMCID: PMC307595 Electroosmotic enhancement of the binding of a neutral molecule to a transmembrane pore Li-Qun Gu, Stephen Cheley, and Hagan Bayley PMCID: PMC307596 Structural basis for PAS domain heterodimerization in the basic helix–loop–helix-PAS transcription factor hypoxia-inducible factor Paul J. A. Erbel, Paul B. Card, Ozgur Karakuzu, Richard K. Bruick, and Kevin H. Gardner PMCID: PMC307597 Channel gating forces govern accuracy of mechano-electrical transduction in hair cells Sietse M. van Netten, Theo Dinklo, Walter Marcotti, and Corné J. Kros PMCID: PMC307598 Single-molecule fluorescence resonance energy transfer reveals a dynamic equilibrium between closed and open conformations of syntaxin 1 M. Margittai, J. Widengren, E. Schweinberger, G. F. Schröder, S. Felekyan, E. Haustein, M. König, D. Fasshauer, H. Grubmüller, R. Jahn, and C. A. M. Seidel PMCID: PMC307599 Network component analysis: Reconstruction of regulatory signals in biological systems James C. Liao, Riccardo Boscolo, Young-Lyeol Yang, Linh My Tran, Chiara Sabatti, and Vwani P. Roychowdhury PMCID: PMC307600 Domain movements of HAP2 in the cap–filament complex formation and growth process of the bacterial flagellum Saori Maki-Yonekura, Koji Yonekura, and Keiichi Namba PMCID: PMC307601 Direct observation of tiers in the energy landscape of a chromoprotein: A single-molecule study Clemens Hofmann, Thijs J. Aartsma, Hartmut Michel, and Jürgen Köhler PMCID: PMC307602 A discrete water exit pathway in the membrane protein cytochrome c oxidase Bryan Schmidt, John McCracken, and Shelagh Ferguson-Miller PMCID: PMC307603 Redox-coupled proton translocation in biological systems: Proton shuttling in cytochrome c oxidase Andreas Namslauer, Ashtamurthy S. Pawate, Robert B. Gennis, and Peter Brzezinski PMCID: PMC307604 Cell Biology From the Cover:
TGF-β-induced RhoA and p160ROCK activation is involved in the inhibition of Cdc25A with resultant cell-cycle arrest Neil A. Bhowmick, Mayshan Ghiassi, Mary Aakre, Kimberly Brown, Vikas Singh, and Harold L. Moses PMCID: PMC307605 Visualizing lipid structure and raft domains in living cells with two-photon microscopy Katharina Gaus, Enrico Gratton, Eleanor P. W. Kable, Allan S. Jones, Ingrid Gelissen, Leonard Kritharides, and Wendy Jessup PMCID: PMC307606 The tetraspanin CD63 enhances the internalization of the H,K-ATPase β-subunit Amy Duffield, Erik-Jan Kamsteeg, Andrea N. Brown, Philipp Pagel, and Michael J. Caplan PMCID: PMC307607 The kinesin KIF17b and RNA-binding protein TB-RBP transport specific cAMP-responsive element modulator-regulated mRNAs in male germ cells Vargheese Chennathukuzhi, Carlos R. Morales, Mohamed El-Alfy, and Norman B. Hecht PMCID: PMC307608 Epstein–Barr virus activates β-catenin in type III latently infected B lymphocyte lines: Association with deubiquitinating enzymes Julia Shackelford, Christopher Maier, and Joseph S. Pagano PMCID: PMC307609 Homeoprotein DLX-1 interacts with Smad4 and blocks a signaling pathway from activin A in hematopoietic cells Shigeru Chiba, Kenichi Takeshita, Yoichi Imai, Keiki Kumano, Mineo Kurokawa, Shigeo Masuda, Kiyoshi Shimizu, Shuji Nakamura, Frank H. Ruddle, and Hisamaru Hirai PMCID: PMC307610 From the Cover:
Membrane tube formation from giant vesicles by dynamic association of motor proteins Gerbrand Koster, Martijn VanDuijn, Bas Hofs, and Marileen Dogterom PMCID: PMC307611 Intracellular localization of a group II chaperonin indicates a membrane-related function Jonathan D. Trent, Hiromi K. Kagawa, Chad D. Paavola, R. Andrew McMillan, Jeanie Howard, Linda Jahnke, Colleen Lavin, Tsegereda Embaye, and Christopher E. Henze PMCID: PMC307612 Epstein–Barr virus latent membrane protein 1 activation of NF-κB through IRAK1 and TRAF6 Micah Luftig, Efthimios Prinarakis, Teruhito Yasui, Theodore Tsichritzis, Ellen Cahir-McFarland, Jun-Ichiro Inoue, Hiroyasu Nakano, Tak Wah Mak, Wen-Chen Yeh, Xiaoxia Li, Shizuo Akira, Nobutaka Suzuki, Shinobu Suzuki, George Mosialos, and Elliott Kieff PMCID: PMC307613 Mullerian Inhibiting Substance inhibits cervical cancer cell growth via a pathway involving p130 and p107 Thanh U. Barbie, David A. Barbie, David T. MacLaughlin, Shyamala Maheswaran, and Patricia K. Donahoe PMCID: PMC307614 Developmental Biology Use of Sindbis virus-mediated RNA interference to demonstrate a conserved role of Broad-Complex in insect metamorphosis Mirka Uhlirova, Brian D. Foy, Barry J. Beaty, Ken E. Olson, Lynn M. Riddiford, and Marek Jindra PMCID: PMC307615 Glucose transporter-1-deficient mice exhibit impaired development and deformities that are similar to diabetic embryopathy Charles W. Heilig, Thomas Saunders, Frank C. Brosius, III, Kelle Moley, Kathleen Heilig, Raymond Baggs, LiRong Guo, and David Conner PMCID: PMC307616 p57Kip2 cooperates with Nurr1 in developing dopamine cells Bertrand Joseph, Åsa Wallén-Mackenzie, Gérard Benoit, Takashi Murata, Eliza Joodmardi, Sam Okret, and Thomas Perlmann PMCID: PMC307617 Marker succession during the development of keratinocytes from cultured human embryonic stem cells Howard Green, Karen Easley, and Shiro Iuchi PMCID: PMC307618 Murine and human zona pellucida 3 derived from mouse eggs express identical O-glycans Anne Dell, Sara Chalabi, Richard L. Easton, Stuart M. Haslam, Mark Sutton-Smith, Manish S. Patankar, Frank Lattanzio, Maria Panico, Howard R. Morris, and Gary F. Clark PMCID: PMC307619 Trophoblast expression of fms-like tyrosine kinase 1 is not required for the establishment of the maternal–fetal interface in the mouse placenta Masanori Hirashima, Yong Lu, Lois Byers, and Janet Rossant PMCID: PMC307620 Ecology Fungal farming in a snail Brian R. Silliman and Steven Y. Newell PMCID: PMC307621 Fungal endophytes limit pathogen damage in a tropical tree A. Elizabeth Arnold, Luis Carlos Mejía, Damond Kyllo, Enith I. Rojas, Zuleyka Maynard, Nancy Robbins, and Edward Allen Herre PMCID: PMC307622 Evolution Extensive gene gain associated with adaptive evolution of poxviruses Aoife McLysaght, Pierre F. Baldi, and Brandon S. Gaut PMCID: PMC307623 Organismal complexity, protein complexity, and gene duplicability Jing Yang, Richard Lusk, and Wen-Hsiung Li PMCID: PMC307624 Divergence of Hoxc8 early enhancer parallels diverged axial morphologies between mammals and fishes Sanjay Anand, Wayne C. H. Wang, Dennis R. Powell, Stacey A. Bolanowski, Jian Zhang, Christina Ledje, Aruna B. Pawashe, Chris T. Amemiya, and Cooduvalli S. Shashikant PMCID: PMC307625 Phylogenomic analysis of type I polyketide synthase genes in pathogenic and saprobic ascomycetes Scott Kroken, N. Louise Glass, John W. Taylor, O. C. Yoder, and B. Gillian Turgeon PMCID: PMC307626 Limited boundaries for extensive horizontal gene transfer among Salmonella pathogens Eric W. Brown, Mark K. Mammel, J. Eugene LeClerc, and Thomas A. Cebula PMCID: PMC307627 The early stages of duplicate gene evolution Richard C. Moore and Michael D. Purugganan PMCID: PMC307628 The compositional adjustment of amino acid substitution matrices Yi-Kuo Yu, John C. Wootton, and Stephen F. Altschul PMCID: PMC307629 Host defense reinforces host–parasite cospeciation Dale H. Clayton, Sarah E. Bush, Brad M. Goates, and Kevin P. Johnson PMCID: PMC307630 Changing identities: tRNA duplication and remolding within animal mitochondrial genomes Timothy A. Rawlings, Timothy M. Collins, and Rüdiger Bieler PMCID: PMC307631 Genetics From the Cover:
Positional cloning and characterization of Mei1, a vertebrate-specific gene required for normal meiotic chromosome synapsis in mice Brian J. Libby, Laura G. Reinholdt, and John C. Schimenti PMCID: PMC307632 Adipose-specific peroxisome proliferator-activated receptor γ knockout causes insulin resistance in fat and liver but not in muscle Weimin He, Yaacov Barak, Andrea Hevener, Peter Olson, Debbie Liao, Jamie Le, Michael Nelson, Estelita Ong, Jerrold M. Olefsky, and Ronald M. Evans PMCID: PMC307633 Gene expression analysis of plant host–pathogen interactions by SuperSAGE Hideo Matsumura, Stefanie Reich, Akiko Ito, Hiromasa Saitoh, Sophien Kamoun, Peter Winter, Günter Kahl, Monika Reuter, Detlev H. Krüger, and Ryohei Terauchi PMCID: PMC307634 High-resolution yeast phenomics resolves different physiological features in the saline response Jonas Warringer, Elke Ericson, Luciano Fernandez, Olle Nerman, and Anders Blomberg PMCID: PMC307635 Plastid protein synthesis is required for plant development in tobacco Daniela Ahlert, Stephanie Ruf, and Ralph Bock PMCID: PMC307636 Activation of a LTR-retrotransposon by telomere erosion Derek T. Scholes, Alison E. Kenny, Eric R. Gamache, Zhongming Mou, and M. Joan Curcio PMCID: PMC307637 A bacterial group II intron favors retrotransposition into plasmid targets Kenji Ichiyanagi, Arthur Beauregard, and Marlene Belfort PMCID: PMC307638 Enhanced levels of λ Red-mediated recombinants in mismatch repair mutants Nina Costantino and Donald L. Court PMCID: PMC307639 Widespread purifying selection at polymorphic sites in human protein-coding loci Austin L. Hughes, Bernice Packer, Robert Welch, Andrew W. Bergen, Stephen J. Chanock, and Meredith Yeager PMCID: PMC307640 Direct and distinguishable inhibitory roles for SUMO isoforms in the control of transcriptional synergy Sam Holmstrom, Mary E. Van Antwerp, and Jorge A. Iñiguez-Lluhí PMCID: PMC307641 Systematic, genome-wide identification of host genes affecting replication of a positive-strand RNA virus David B. Kushner, Brett D. Lindenbach, Valery Z. Grdzelishvili, Amine O. Noueiry, Scott M. Paul, and Paul Ahlquist PMCID: PMC307642 Two different Swi5-containing protein complexes are involved in mating-type switching and recombination repair in fission yeast Yufuko Akamatsu, Dorota Dziadkowiec, Mitsunori Ikeguchi, Hideo Shinagawa, and Hiroshi Iwasaki PMCID: PMC307643 Cap analysis gene expression for high-throughput analysis of transcriptional starting point and identification of promoter usage Toshiyuki Shiraki, Shinji Kondo, Shintaro Katayama, Kazunori Waki, Takeya Kasukawa, Hideya Kawaji, Rimantas Kodzius, Akira Watahiki, Mari Nakamura, Takahiro Arakawa, Shiro Fukuda, Daisuke Sasaki, Anna Podhajska, Matthias Harbers, Jun Kawai, Piero Carninci, and Yoshihide Hayashizaki PMCID: PMC307644 Endonuclease G is required for early embryogenesis and normal apoptosis in mice Jianhua Zhang, Mei Dong, Lily Li, Yunxia Fan, Purnima Pathre, Jin Dong, Danwen Lou, James M. Wells, Danyvid Olivares-Villagómez, Luc Van Kaer, Xiaodong Wang, and Ming Xu PMCID: PMC307645 Contribution of the H63D mutation in HFE to murine hereditary hemochromatosis Shunji Tomatsu, Koji O. Orii, Robert E. Fleming, Christopher C. Holden, Abdul Waheed, Robert S. Britton, Monica A. Gutierrez, Susana Velez-Castrillon, Bruce R. Bacon, and William S. Sly PMCID: PMC307646 The Drosophila homolog of Down's syndrome critical region 1 gene regulates learning: Implications for mental retardation Karen T. Chang, Yi-Jun Shi, and Kyung-Tai Min PMCID: PMC307647 Immunology IκBα/IκBε deficiency reveals that a critical NF-κB dosage is required for lymphocyte survival Bertrand Goudeau, François Huetz, Sandrine Samson, James P. Di Santo, Ana Cumano, Amer Beg, Alain Israël, and Sylvie Mémet PMCID: PMC307648 Diversity of regulatory CD4+T cells controlling distinct organ-specific autoimmune diseases Marie-Alexandra Alyanakian, Sylvaine You, Diane Damotte, Christine Gouarin, Anne Esling, Corinne Garcia, Séverine Havouis, Lucienne Chatenoud, and Jean-François Bach PMCID: PMC307649 Electron tomography analysis of envelope glycoprotein trimers on HIV and simian immunodeficiency virus virions Ping Zhu, Elena Chertova, Julian Bess, Jr., Jeffrey D. Lifson, Larry O. Arthur, Jun Liu, Kenneth A. Taylor, and Kenneth H. Roux PMCID: PMC307650 Antigen-driven effector CD8 T cell function regulated by T-bet Brandon M. Sullivan, Amy Juedes, Susanne J. Szabo, Matthias von Herrath, and Laurie H. Glimcher PMCID: PMC307651 Cell surface expression of an endoplasmic reticulum resident heat shock protein gp96 triggers MyD88-dependent systemic autoimmune diseases Bei Liu, Jie Dai, Hong Zheng, Diliana Stoilova, Shaoli Sun, and Zihai Li PMCID: PMC307652 Induction of colitis by a CD4+ T cell clone specific for a bacterial epitope Marika C. Kullberg, John F. Andersen, Peter L. Gorelick, Patricia Caspar, Sebastian Suerbaum, James G. Fox, Allen W. Cheever, Dragana Jankovic, and Alan Sher PMCID: PMC307653 Medical Sciences Inhibition of mutant p53 expression and growth of DMS-153 small cell lung carcinoma by antagonists of growth hormone-releasing hormone and bombesin Celia A. Kanashiro, Andrew V. Schally, Kate Groot, Patricia Armatis, Andrea L. F. Bernardino, and Jozsef L. Varga PMCID: PMC307654 Activation of latent myostatin by the BMP-1/tolloid family of metalloproteinases Neil M. Wolfman, Alexandra C. McPherron, William N. Pappano, Monique V. Davies, Kening Song, Kathleen N. Tomkinson, Jill F. Wright, Liz Zhao, Suzanne M. Sebald, Daniel S. Greenspan, and Se-Jin Lee PMCID: PMC307655 Anion exchanger 2 is essential for spermiogenesis in mice Juan F. Medina, Sergio Recalde, Jesús Prieto, Jon Lecanda, Elena Sáez, Colin D. Funk, Paola Vecino, Marian A. van Roon, Roelof Ottenhoff, Piter J. Bosma, Conny T. Bakker, and Ronald P. J. Oude Elferink PMCID: PMC307656 Evidence that transgenes encoding components of the Wnt signaling pathway preferentially induce mammary cancers from progenitor cells Yi Li, Bryan Welm, Katrina Podsypanina, Shixia Huang, Mario Chamorro, Xiaomei Zhang, Tracey Rowlands, Mikala Egeblad, Pam Cowin, Zena Werb, Lee K. Tan, Jeffrey M. Rosen, and Harold E. Varmus PMCID: PMC307657 Transforming growth factor β1 induction of vascular endothelial growth factor receptor 1: Mechanism of pericyte-induced vascular survival in vivo Shu-Ching Shih, Meihua Ju, Nan Liu, Jan-Rung Mo, Joshua J. Ney, and Lois E. H. Smith PMCID: PMC307658 Disruption of hepatitis C virus RNA replication through inhibition of host protein geranylgeranylation Jin Ye, Chunfu Wang, Rhea Sumpter, Jr., Michael S. Brown, Joseph L. Goldstein, and Michael Gale, Jr. PMCID: PMC307659 Antitumor efficacy of cytotoxic drugs and the monoclonal antibody 806 is enhanced by the EGF receptor inhibitor AG1478 Terrance G. Johns, Rodney B. Luwor, Carmel Murone, Francesca Walker, Janet Weinstock, Angela A. Vitali, Rushika M. Perera, Achim A. Jungbluth, Elisabeth Stockert, Lloyd J. Old, Edouard C. Nice, Antony W. Burgess, and Andrew M. Scott PMCID: PMC307660 Primitive adult hematopoietic stem cells can function as osteoblast precursors Elizabeth A. Olmsted-Davis, Zbigniew Gugala, Fernando Camargo, Francis H. Gannon, KathyJo Jackson, Kirsten Anderson Kienstra, H. David Shine, Ronald W. Lindsey, Karen K. Hirschi, Margaret A. Goodell, Malcolm K. Brenner, and Alan R. Davis PMCID: PMC307661 Targeted deletion of apoptosis signal-regulating kinase 1 attenuates left ventricular remodeling Osamu Yamaguchi, Yoshiharu Higuchi, Shinichi Hirotani, Kazunori Kashiwase, Hiroyuki Nakayama, Shungo Hikoso, Toshihiro Takeda, Tetsuya Watanabe, Michio Asahi, Masayuki Taniike, Yasushi Matsumura, Ikuko Tsujimoto, Kenichi Hongo, Yoichiro Kusakari, Satoshi Kurihara, Kazuhiko Nishida, Hidenori Ichijo, Masatsugu Hori, and Kinya Otsu PMCID: PMC307662 Ebola virus-like particles protect from lethal Ebola virus infection Kelly L. Warfield, Catharine M. Bosio, Brent C. Welcher, Emily M. Deal, Mansour Mohamadzadeh, Alan Schmaljohn, M. Javad Aman, and Sina Bavari PMCID: PMC307663 Leukocyte-inspired biodegradable particles that selectively and avidly adhere to inflamed endothelium in vitro and in vivo Harshad S. Sakhalkar, Milind K. Dalal, Aliasger K. Salem, Ramin Ansari, Jie Fu, Mohammad F. Kiani, David T. Kurjiaka, Justin Hanes, Kevin M. Shakesheff, and Douglas J. Goetz PMCID: PMC307664 Gene expression profiles of primary breast tumors maintained in distant metastases Britta Weigelt, Annuska M. Glas, Lodewyk F. A. Wessels, Anke T. Witteveen, Johannes L. Peterse, and Laura J. van't Veer PMCID: PMC307665 Transgenic mouse model for echovirus myocarditis and paralysis Scott A. Hughes, Harshwardhan M. Thaker, and Vincent R. Racaniello PMCID: PMC307666 Chemical chaperone therapy for brain pathology in GM1-gangliosidosis Junichiro Matsuda, Osamu Suzuki, Akihiro Oshima, Yoshie Yamamoto, Akira Noguchi, Kazuhiro Takimoto, Masayuki Itoh, Yuji Matsuzaki, Yosuke Yasuda, Seiichiro Ogawa, Yuko Sakata, Eiji Nanba, Katsumi Higaki, Yoshimi Ogawa, Lika Tominaga, Kousaku Ohno, Hiroyuki Iwasaki, Hiroshi Watanabe, Roscoe O. Brady, and Yoshiyuki Suzuki PMCID: PMC307667 Hypervirulent mutant of Mycobacterium tuberculosis resulting from disruption of the mce1 operon Nobuyuki Shimono, Lisa Morici, Nicola Casali, Sally Cantrell, Ben Sidders, Sabine Ehrt, and Lee W. Riley PMCID: PMC307668 Activation of peroxisome proliferator-activated receptor δ induces fatty acid β-oxidation in skeletal muscle and attenuates metabolic syndrome Toshiya Tanaka, Joji Yamamoto, Satoshi Iwasaki, Hiroshi Asaba, Hiroki Hamura, Yukio Ikeda, Mitsuhiro Watanabe, Kenta Magoori, Ryoichi X. Ioka, Keisuke Tachibana, Yuichiro Watanabe, Yasutoshi Uchiyama, Koichi Sumi, Haruhisa Iguchi, Sadayoshi Ito, Takefumi Doi, Takao Hamakubo, Makoto Naito, Johan Auwerx, Masashi Yanagisawa, Tatsuhiko Kodama, and Juro Sakai PMCID: PMC307669 Arf tumor suppressor promoter monitors latent oncogenic signals in vivo Frederique Zindy, Richard T. Williams, Troy A. Baudino, Jerold E. Rehg, Stephen X. Skapek, John L. Cleveland, Martine F. Roussel, and Charles J. Sherr PMCID: PMC307670 Microbiology In vivo oligomerization and raft localization of Ebola virus protein VP40 during vesicular budding Rekha G. Panchal, Gordon Ruthel, Tara A. Kenny, George H. Kallstrom, Douglas Lane, Shirin S. Badie, Limin Li, Sina Bavari, and M. Javad Aman PMCID: PMC307671 Binding of Plasmodium falciparum-infected erythrocytes to the membrane-bound form of Fractalkine/CX3CL1 Toshimitsu Hatabu, Shin-ichiro Kawazu, Masamichi Aikawa, and Shigeyuki Kano PMCID: PMC307672 Structural and functional characterization of the VirB5 protein from the type IV secretion system encoded by the conjugative plasmid pKM101 Hye-Jeong Yeo, Qing Yuan, Moriah R. Beck, Christian Baron, and Gabriel Waksman PMCID: PMC307673 Borrelia burgdorferi transcriptome in the central nervous system of non-human primates Sukanya Narasimhan, Melissa J. Camaino, Fang Ting Liang, Felix Santiago, Michelle Laskowski, Mario T. Philipp, Andrew R. Pachner, Justin D. Radolf, and Erol Fikrig PMCID: PMC307674 A role for mechanosensitive channels in survival of stationary phase: Regulation of channel expression by RpoS Neil R. Stokes, Heath D. Murray, Chandrasekaran Subramaniam, Richard L. Gourse, Petra Louis, Wendy Bartlett, Samantha Miller, and Ian R. Booth PMCID: PMC307675 Enhanced biocontrol activity of Trichoderma through inactivation of a mitogen-activated protein kinase Artemio Mendoza-Mendoza, María J. Pozo, Darlene Grzegorski, Pedro Martínez, Juan M. García, Vianey Olmedo-Monfil, Carlos Cortés, Charles Kenerley, and Alfredo Herrera-Estrella PMCID: PMC307676 Transcriptome analysis of chlamydial growth during IFN-γ-mediated persistence and reactivation Robert J. Belland, David E. Nelson, Dezso Virok, Deborah D. Crane, Daniel Hogan, Daniel Sturdevant, Wandy L. Beatty, and Harlan D. Caldwell PMCID: PMC307677 Differential survival of solitary and aggregated bacterial cells promotes aggregate formation on leaf surfaces J.-M. Monier and S. E. Lindow PMCID: PMC307678 Neuroscience Migration and differentiation of neural precursor cells can be directed by microglia Johan Aarum, Kristian Sandberg, Samantha L. Budd Haeberlein, and Mats A. A. Persson PMCID: PMC307679 Reversing cerebellar long-term depression Varda Lev-Ram, Samar B. Mehta, David Kleinfeld, and Roger Y. Tsien PMCID: PMC307680 Heterogeneity of rhythmic suprachiasmatic nucleus neurons: Implications for circadian waveform and photoperiodic encoding Jeroen Schaap, Henk Albus, Henk Tjebbe vanderLeest, Paul H. C. Eilers, László Détári, and Johanna H. Meijer PMCID: PMC307681 Dissociation of spikes, synaptic activity, and activity-dependent increments in rat cerebellar blood flow by tonic synaptic inhibition Kirsten Caesar, Kirsten Thomsen, and Martin Lauritzen PMCID: PMC307682 Protein phosphatase 2C binds selectively to and dephosphorylates metabotropic glutamate receptor 3 Marc Flajolet, Sergey Rakhilin, Hong Wang, Natalia Starkova, Nina Nuangchamnong, Angus C. Nairn, and Paul Greengard PMCID: PMC307683 Fundamental role of the Rip2/caspase-1 pathway in hypoxia and ischemia-induced neuronal cell death Wen-Hua Zhang, Xin Wang, Malini Narayanan, Yu Zhang, Chunfeng Huo, John C. Reed, and Robert M. Friedlander PMCID: PMC307684 Increased phosphorylation of the neuronal L-type Ca2+ channel Cav1.2 during aging Monika A. Davare and Johannes W. Hell PMCID: PMC307685 Motility of dendritic spines in visual cortex in vivo: Changes during the critical period and effects of visual deprivation Ania Majewska and Mriganka Sur PMCID: PMC307686 Molecular basis of calcium regulation in connexin-32 hemichannels Juan M. Gómez-Hernández, Marta de Miguel, Belen Larrosa, Daniel González, and Luis C. Barrio PMCID: PMC307687 Symmetry considerations and development of pinwheels in visual maps Ha Youn Lee, Mehdi Yahyanejad, and Mehran Kardar PMCID: PMC307688 Unstable mutants in the peripheral endosomal membrane component ALS2 cause early-onset motor neuron disease Koji Yamanaka, Christine Vande Velde, Eleonore Eymard-Pierre, Enrico Bertini, Odile Boespflug-Tanguy, and Don W. Cleveland PMCID: PMC307689 Cation–chloride cotransporters mediate neural computation in the retina Konstantin E. Gavrikov, Andrey V. Dmitriev, Kent T. Keyser, and Stuart C. Mangel PMCID: PMC307690 Dynamic analysis of larval locomotion in Drosophila chordotonal organ mutants Jason C. Caldwell, Matthew M. Miller, Susan Wing, David R. Soll, and Daniel F. Eberl PMCID: PMC307691 Molecular determinants of Ca2+/calmodulin-dependent regulation of Cav2.1 channels Amy Lee, Hong Zhou, Todd Scheuer, and William A. Catterall PMCID: PMC307692 Contribution of transient receptor potential channels to the control of GABA release from dendrites Thomas Munsch, Marc Freichel, Veit Flockerzi, and Hans-Christian Pape PMCID: PMC307693 Targeting Schwann cells by nonlytic arenaviral infection selectively inhibits myelination Anura Rambukkana, Stefan Kunz, Jenny Min, Kevin P. Campbell, and Michael B. A. Oldstone PMCID: PMC307694 Pharmacology From the Cover:
Gi protein activation in intact cells involves subunit rearrangement rather than dissociation Moritz Bünemann, Monika Frank, and Martin J. Lohse PMCID: PMC307695 Physiology Abnormal surface liquid pH regulation by cultured cystic fibrosis bronchial epithelium Raymond D. Coakley, Barbara R. Grubb, Anthony M. Paradiso, John T. Gatzy, Larry G. Johnson, Sylvia M. Kreda, Wanda K. O'Neal, and Richard C. Boucher PMCID: PMC307696 Circadian gene expression in mammalian fibroblasts revealed by real-time luminescence reporting: Temperature compensation and damping Mariko Izumo, Carl Hirschie Johnson, and Shin Yamazaki PMCID: PMC307697 Plant Biology Vacuolar sorting receptor for seed storage proteins in Arabidopsis thaliana Tomoo Shimada, Kentaro Fuji, Kentaro Tamura, Maki Kondo, Mikio Nishimura, and Ikuko Hara-Nishimura PMCID: PMC307698 High-affinity salicylic acid-binding protein 2 is required for plant innate immunity and has salicylic acid-stimulated lipase activity Dhirendra Kumar and Daniel F. Klessig PMCID: PMC307699 Thioredoxin-linked processes in cyanobacteria are as numerous as in chloroplasts, but targets are different Marika Lindahl and Francisco J. Florencio PMCID: PMC307700 A comprehensive analysis of hydrogen peroxide-induced gene expression in tobacco Steven Vandenabeele, Katrien Van Der Kelen, James Dat, Ilya Gadjev, Tom Boonefaes, Stijn Morsa, Pieter Rottiers, Luit Slooten, Marc Van Montagu, Marc Zabeau, Dirk Inzé, and Frank Van Breusegem PMCID: PMC307701 Arabidopsis CHL27, located in both envelope and thylakoid membranes, is required for the synthesis of protochlorophyllide Stephen Tottey, Maryse A. Block, Michael Allen, Tomas Westergren, Catherine Albrieux, Henrik V. Scheller, Sabeeha Merchant, and Poul Erik Jensen PMCID: PMC307702 From the Cover:
Chemocyanin, a small basic protein from the lily stigma, induces pollen tube chemotropism Sunran Kim, Jean-Claude Mollet, Juan Dong, Kangling Zhang, Sang-Youl Park, and Elizabeth M. Lord PMCID: PMC307703 Psychology Fear of novelty in infant rats predicts adult corticosterone dynamics and an early death S. A. Cavigelli and M. K. McClintock PMCID: PMC307704 Juvenile emotional experience alters synaptic composition in the rodent cortex, hippocampus, and lateral amygdala Gerd Poeggel, Carina Helmeke, Andreas Abraham, Tina Schwabe, Patricia Friedrich, and Katharina Braun PMCID: PMC307705 Corrections Proc Natl Acad Sci U S A. 2003 December 23; 100(26): 16143–16144. Published online 2003 December 11. doi: 10.1073/pnas.2637073100.PMCID: PMC307706 Corrects: Stephane Wong, et al. IL-3 receptor signaling is dispensable for BCR-ABL-induced myeloproliferative disease. Proc Natl Acad Sci U S A. 2003 September 30; 100(20): 11630–11635. Proc Natl Acad Sci U S A. 2003 December 23; 100(26): 16144. Published online 2003 December 2. doi: 10.1073/pnas.2637015100.PMCID: PMC307707 Corrects: John F. Leite, et al. Conformation-dependent hydrophobic photolabeling of the nicotinic receptor: Electrophysiology-coordinated photochemistry and mass spectrometry. Proc Natl Acad Sci U S A. 2003 October 28; 100(22): 13054–13059. |
