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Volume 100(21);  October 14, 2003
Commentaries
Ecological subsidies alter the structure of marine communities
Stephen R. Palumbi
Proc Natl Acad Sci U S A. 2003 October 14; 100(21): 11927–11928. Published online 2003 October 6. doi: 10.1073/pnas.2335832100.
PMCID: PMC218687
Genetic footprinting of a retroviral Gag gene suggests an important role in virus replication
Alan Rein
Proc Natl Acad Sci U S A. 2003 October 14; 100(21): 11929–11930. Published online 2003 October 6. doi: 10.1073/pnas.2135539100.
PMCID: PMC218688
How an enzyme surmounts the activation energy barrier
Richard L. Schowen
Proc Natl Acad Sci U S A. 2003 October 14; 100(21): 11931–11932. Published online 2003 October 6. doi: 10.1073/pnas.2235806100.
PMCID: PMC218689
The dynamics of the spread of selective visual attention
Michael S. Worden and John J. Foxe
Proc Natl Acad Sci U S A. 2003 October 14; 100(21): 11933–11935. Published online 2003 October 6. doi: 10.1073/pnas.2135485100.
PMCID: PMC218690
Physical Sciences
Applied Mathematics
Matching protein structures with fuzzy alignments
Richard Blankenbecler, Mattias Ohlsson, Carsten Peterson, and Markus Ringnér
Proc Natl Acad Sci U S A. 2003 October 14; 100(21): 11936–11940. Published online 2003 October 2. doi: 10.1073/pnas.1635048100.
PMCID: PMC218691
Coarse-grained stochastic models for tropical convection and climate
Boualem Khouider, Andrew J. Majda, and Markos A. Katsoulakis
Proc Natl Acad Sci U S A. 2003 October 14; 100(21): 11941–11946. Published online 2003 September 30. doi: 10.1073/pnas.1634951100.
PMCID: PMC218692
Applied Physical Sciences
Self-organized queuing and scale-free behavior in real escape panic
Caesar Saloma, Gay Jane Perez, Giovanni Tapang, May Lim, and Cynthia Palmes-Saloma
Proc Natl Acad Sci U S A. 2003 October 14; 100(21): 11947–11952. Published online 2003 September 30. doi: 10.1073/pnas.2031912100.
PMCID: PMC218693
Chemistry
Dewetting-induced collapse of hydrophobic particles
X. Huang, C. J. Margulis, and B. J. Berne
Proc Natl Acad Sci U S A. 2003 October 14; 100(21): 11953–11958. Published online 2003 September 24. doi: 10.1073/pnas.1934837100.
PMCID: PMC218694
Rapid PCR amplification of minimal enediyne polyketide synthase cassettes leads to a predictive familial classification model
Wen Liu, Joachim Ahlert, Qunjie Gao, Evelyn Wendt-Pienkowski, Ben Shen, and Jon S. Thorson
Proc Natl Acad Sci U S A. 2003 October 14; 100(21): 11959–11963. Published online 2003 October 3. doi: 10.1073/pnas.2034291100.
PMCID: PMC218695
Enzyme screening with synthetic multifunctional pores: Focus on biopolymers
Nathalie Sordé, Gopal Das, and Stefan Matile
Proc Natl Acad Sci U S A. 2003 October 14; 100(21): 11964–11969. Published online 2003 October 6. doi: 10.1073/pnas.2132894100.
PMCID: PMC218696
Self-organization by selection: Generation of a metallosupramolecular grid architecture by selection of components in a dynamic library of ligands
Jonathan R. Nitschke and Jean-Marie Lehn
Proc Natl Acad Sci U S A. 2003 October 14; 100(21): 11970–11974. Published online 2003 September 29. doi: 10.1073/pnas.1534925100.
PMCID: PMC218697
Mechanism and energetics of green fluorescent protein chromophore synthesis revealed by trapped intermediate structures
David P. Barondeau, Christopher D. Putnam, Carey J. Kassmann, John A. Tainer, and Elizabeth D. Getzoff
Proc Natl Acad Sci U S A. 2003 October 14; 100(21): 12111–12116. Published online 2003 October 1. doi: 10.1073/pnas.2133463100.
PMCID: PMC218721
Geophysics
Extensive regional atmospheric hydrocarbon pollution in the southwestern United States
Aaron S. Katzenstein, Lambert A. Doezema, Isobel J. Simpson, Donald R. Blake, and F. Sherwood Rowland
Proc Natl Acad Sci U S A. 2003 October 14; 100(21): 11975–11979. Published online 2003 October 6. doi: 10.1073/pnas.1635258100.
PMCID: PMC218698
Physics
Structure and function of the feed-forward loop network motif
S. Mangan and U. Alon
Proc Natl Acad Sci U S A. 2003 October 14; 100(21): 11980–11985. Published online 2003 October 6. doi: 10.1073/pnas.2133841100.
PMCID: PMC218699
Biological Sciences
Agricultural Sciences
Juvenile hormone acid methyltransferase: A key regulatory enzyme for insect metamorphosis
Tetsuro Shinoda and Kyo Itoyama
Proc Natl Acad Sci U S A. 2003 October 14; 100(21): 11986–11991. Published online 2003 October 6. doi: 10.1073/pnas.2134232100.
PMCID: PMC218700
Anthropology
Rates of anterior tooth wear in Middle Pleistocene hominins from Sima de los Huesos (Sierra de Atapuerca, Spain)
J. M. Bermúdez de Castro, M. Martinón-Torres, S. Sarmiento, M. Lozano, J. L. Arsuaga, and E. Carbonell
Proc Natl Acad Sci U S A. 2003 October 14; 100(21): 11992–11996. Published online 2003 October 3. doi: 10.1073/pnas.2034879100.
PMCID: PMC218701
Applied Biological Sciences
Zinc-finger protein-targeted gene regulation: Genomewide single-gene specificity
Siyuan Tan, Dmitry Guschin, Albert Davalos, Ya-Li Lee, Andrew W. Snowden, Yann Jouvenot, H. Steven Zhang, Katherine Howes, Andrew R. McNamara, Albert Lai, Chris Ullman, Lindsey Reynolds, Michael Moore, Mark Isalan, Lutz-Peter Berg, Bradley Campos, Hong Qi, S. Kaye Spratt, Casey C. Case, Carl O. Pabo, Judith Campisi, and Philip D. Gregory
Proc Natl Acad Sci U S A. 2003 October 14; 100(21): 11997–12002. Published online 2003 September 26. doi: 10.1073/pnas.2035056100.
PMCID: PMC218702
Biochemistry
Activation domain–mediator interactions promote transcription preinitiation complex assembly on promoter DNA
Greg T. Cantin, Jennitte L. Stevens, and Arnold J. Berk
Proc Natl Acad Sci U S A. 2003 October 14; 100(21): 12003–12008. Published online 2003 September 23. doi: 10.1073/pnas.2035253100.
PMCID: PMC218703
HdmX stimulates Hdm2-mediated ubiquitination and degradation of p53
Laëtitia K. Linares, Arnd Hengstermann, Aaron Ciechanover, Stefan Müller, and Martin Scheffner
Proc Natl Acad Sci U S A. 2003 October 14; 100(21): 12009–12014. Published online 2003 September 24. doi: 10.1073/pnas.2030930100.
PMCID: PMC218704
From the Cover:
The near attack conformation approach to the study of the chorismate to prephenate reaction
Sun Hur and Thomas C. Bruice
Proc Natl Acad Sci U S A. 2003 October 14; 100(21): 12015–12020. Published online 2003 October 1. doi: 10.1073/pnas.1534873100.
PMCID: PMC218705
Insights into peptide nucleic acid (PNA) structural features: The crystal structure of a d-lysine-based chiral PNA–DNA duplex
Valeria Menchise, Giuseppina De Simone, Tullia Tedeschi, Roberto Corradini, Stefano Sforza, Rosangela Marchelli, Domenica Capasso, Michele Saviano, and Carlo Pedone
Proc Natl Acad Sci U S A. 2003 October 14; 100(21): 12021–12026. Published online 2003 September 25. doi: 10.1073/pnas.2034746100.
PMCID: PMC218706
Combined analysis of oligonucleotide microarray data from transgenic and knockout mice identifies direct SREBP target genes
Jay D. Horton, Nila A. Shah, Janet A. Warrington, Norma N. Anderson, Sahng Wook Park, Michael S. Brown, and Joseph L. Goldstein
Proc Natl Acad Sci U S A. 2003 October 14; 100(21): 12027–12032. Published online 2003 September 25. doi: 10.1073/pnas.1534923100.
PMCID: PMC218707
Facile synthesis of site-specifically acetylated and methylated histone proteins: Reagents for evaluation of the histone code hypothesis
Shu He, David Bauman, Jamaine S. Davis, Alejandra Loyola, Kenichi Nishioka, Jennifer L. Gronlund, Danny Reinberg, Fanyu Meng, Neil Kelleher, and Dewey G. McCafferty
Proc Natl Acad Sci U S A. 2003 October 14; 100(21): 12033–12038. Published online 2003 October 6. doi: 10.1073/pnas.2035256100.
PMCID: PMC218708
Functional map and domain structure of MET, the product of the c-met protooncogene and receptor for hepatocyte growth factor/scatter factor
Ermanno Gherardi, Mark E. Youles, Ricardo N. Miguel, Tom L. Blundell, Luisa Iamele, Julian Gough, Abhishek Bandyopadhyay, Guido Hartmann, and P. Jonathan G. Butler
Proc Natl Acad Sci U S A. 2003 October 14; 100(21): 12039–12044. Published online 2003 October 3. doi: 10.1073/pnas.2034936100.
PMCID: PMC218709
Human uptake and incorporation of an immunogenic nonhuman dietary sialic acid
Pam Tangvoranuntakul, Pascal Gagneux, Sandra Diaz, Muriel Bardor, Nissi Varki, Ajit Varki, and Elaine Muchmore
Proc Natl Acad Sci U S A. 2003 October 14; 100(21): 12045–12050. Published online 2003 October 1. doi: 10.1073/pnas.2131556100.
PMCID: PMC218710
Thrombomodulin allosterically modulates the activity of the anticoagulant thrombin
Alireza R. Rezaie and Likui Yang
Proc Natl Acad Sci U S A. 2003 October 14; 100(21): 12051–12056. Published online 2003 October 1. doi: 10.1073/pnas.2135346100.
PMCID: PMC218711
The L box regulon: Lysine sensing by leader RNAs of bacterial lysine biosynthesis genes
Frank J. Grundy, Susan C. Lehman, and Tina M. Henkin
Proc Natl Acad Sci U S A. 2003 October 14; 100(21): 12057–12062. Published online 2003 October 1. doi: 10.1073/pnas.2133705100.
PMCID: PMC218712
Nuclear localization of pyrrole–imidazole polyamide–fluorescein conjugates in cell culture
Timothy P. Best, Benjamin S. Edelson, Nicholas G. Nickols, and Peter B. Dervan
Proc Natl Acad Sci U S A. 2003 October 14; 100(21): 12063–12068. Published online 2003 September 30. doi: 10.1073/pnas.2035074100.
PMCID: PMC218713
Nucleation-dependent conformational conversion of the Y145Stop variant of human prion protein: Structural clues for prion propagation
Bishwajit Kundu, Nilesh R. Maiti, Eric M. Jones, Krystyna A. Surewicz, David L. Vanik, and Witold K. Surewicz
Proc Natl Acad Sci U S A. 2003 October 14; 100(21): 12069–12074. Published online 2003 September 30. doi: 10.1073/pnas.2033281100.
PMCID: PMC218714
Biosilica formation in diatoms: Characterization of native silaffin-2 and its role in silica morphogenesis
Nicole Poulsen, Manfred Sumper, and Nils Kröger
Proc Natl Acad Sci U S A. 2003 October 14; 100(21): 12075–12080. Published online 2003 September 24. doi: 10.1073/pnas.2035131100.
PMCID: PMC218715
DcpS can act in the 5′–3′ mRNA decay pathway in addition to the 3′–5′ pathway
Erwin van Dijk, Hervé Le Hir, and Bertrand Séraphin
Proc Natl Acad Sci U S A. 2003 October 14; 100(21): 12081–12086. Published online 2003 October 1. doi: 10.1073/pnas.1635192100.
PMCID: PMC218716
The case of the missing NO– hemoglobin: Spectral changes suggestive of heme redox reactions reflect changes in NO– heme geometry
Angela Fago, Alvin L. Crumbliss, Jim Peterson, Linda L. Pearce, and Celia Bonaventura
Proc Natl Acad Sci U S A. 2003 October 14; 100(21): 12087–12092. Published online 2003 September 26. doi: 10.1073/pnas.2032603100.
PMCID: PMC218717
Mechanism of nucleotide incorporation opposite a thymine-thymine dimer by yeast DNA polymerase η
M. Todd Washington, Louise Prakash, and Satya Prakash
Proc Natl Acad Sci U S A. 2003 October 14; 100(21): 12093–12098. Published online 2003 October 3. doi: 10.1073/pnas.2134223100.
PMCID: PMC218718
Biophysics
Noise and stochastic resonance in voltage-gated ion channels
Robert K. Adair
Proc Natl Acad Sci U S A. 2003 October 14; 100(21): 12099–12104. Published online 2003 September 23. doi: 10.1073/pnas.2034447100.
PMCID: PMC218719
Coupled prediction of protein secondary and tertiary structure
Jens Meiler and David Baker
Proc Natl Acad Sci U S A. 2003 October 14; 100(21): 12105–12110. Published online 2003 October 3. doi: 10.1073/pnas.1831973100.
PMCID: PMC218720
Mechanism and energetics of green fluorescent protein chromophore synthesis revealed by trapped intermediate structures
David P. Barondeau, Christopher D. Putnam, Carey J. Kassmann, John A. Tainer, and Elizabeth D. Getzoff
Proc Natl Acad Sci U S A. 2003 October 14; 100(21): 12111–12116. Published online 2003 October 1. doi: 10.1073/pnas.2133463100.
PMCID: PMC218721
How fast is protein hydrophobic collapse?
Mourad Sadqi, Lisa J. Lapidus, and Victor Muñoz
Proc Natl Acad Sci U S A. 2003 October 14; 100(21): 12117–12122. Published online 2003 October 6. doi: 10.1073/pnas.2033863100.
PMCID: PMC218722
Protein complexes and functional modules in molecular networks
Victor Spirin and Leonid A. Mirny
Proc Natl Acad Sci U S A. 2003 October 14; 100(21): 12123–12128. Published online 2003 September 29. doi: 10.1073/pnas.2032324100.
PMCID: PMC218723
Transition-path sampling of β-hairpin folding
Peter G. Bolhuis
Proc Natl Acad Sci U S A. 2003 October 14; 100(21): 12129–12134. Published online 2003 October 1. doi: 10.1073/pnas.1534924100.
PMCID: PMC218724
Biomolecular hydration: From water dynamics to hydrodynamics
Bertil Halle and Monika Davidovic
Proc Natl Acad Sci U S A. 2003 October 14; 100(21): 12135–12140. Published online 2003 October 3. doi: 10.1073/pnas.2033320100.
PMCID: PMC218725
Kinks, rings, and rackets in filamentous structures
Adam E. Cohen and L. Mahadevan
Proc Natl Acad Sci U S A. 2003 October 14; 100(21): 12141–12146. Published online 2003 October 6. doi: 10.1073/pnas.1534600100.
PMCID: PMC218726
Cell Biology
From the Cover:
Identification of a family of cAMP response element-binding protein coactivators by genome-scale functional analysis in mammalian cells
Vadim Iourgenko, Wenjun Zhang, Craig Mickanin, Ira Daly, Can Jiang, Jonathan M. Hexham, Anthony P. Orth, Loren Miraglia, Jodi Meltzer, Dan Garza, Gung-Wei Chirn, Elizabeth McWhinnie, Dalia Cohen, Joanne Skelton, Robert Terry, Yang Yu, Dale Bodian, Frank P. Buxton, Jian Zhu, Chuanzheng Song, and Mark A. Labow
Proc Natl Acad Sci U S A. 2003 October 14; 100(21): 12147–12152. Published online 2003 September 23. doi: 10.1073/pnas.1932773100.
PMCID: PMC218727
From the Cover:
Genome-scale functional profiling of the mammalian AP-1 signaling pathway
Sumit K. Chanda, Suhaila White, Anthony P. Orth, Richard Reisdorph, Loren Miraglia, Russell S. Thomas, Paul DeJesus, Daniel E. Mason, Qihong Huang, Raquel Vega, De-Hua Yu, Christian G. Nelson, Brendan M. Smith, Robert Terry, Alicia S. Linford, Yang Yu, Gung-wei Chirn, Chuanzheng Song, Mark A. Labow, Dalia Cohen, Frederick J. King, Eric C. Peters, Peter G. Schultz, Peter K. Vogt, John B. Hogenesch, and Jeremy S. Caldwell
Proc Natl Acad Sci U S A. 2003 October 14; 100(21): 12153–12158. Published online 2003 September 26. doi: 10.1073/pnas.1934839100.
PMCID: PMC218728
Origins of mitochondrial thymidine triphosphate: Dynamic relations to cytosolic pools
Giovanna Pontarin, Lisa Gallinaro, Paola Ferraro, Peter Reichard, and Vera Bianchi
Proc Natl Acad Sci U S A. 2003 October 14; 100(21): 12159–12164. Published online 2003 September 30. doi: 10.1073/pnas.1635259100.
PMCID: PMC218729
Nuclear localization of 5-lipoxygenase as a determinant of leukotriene B4 synthetic capacity
Ming Luo, Sandra M. Jones, Marc Peters-Golden, and Thomas G. Brock
Proc Natl Acad Sci U S A. 2003 October 14; 100(21): 12165–12170. Published online 2003 October 6. doi: 10.1073/pnas.2133253100.
PMCID: PMC218730
Microtubule destabilization and nuclear entry are sequential steps leading to toxicity in Huntington's disease
Eugenia Trushina, Michael P. Heldebrant, Carmen M. Perez-Terzic, Ryan Bortolon, Irina V. Kovtun, John D. Badger, II, Andre Terzic, Alvaro Estévez, Anthony J. Windebank, Roy B. Dyer, Janet Yao, and Cynthia T. McMurray
Proc Natl Acad Sci U S A. 2003 October 14; 100(21): 12171–12176. Published online 2003 October 3. doi: 10.1073/pnas.2034961100.
PMCID: PMC218731
Membrane association of myotubularin-related protein 2 is mediated by a pleckstrin homology-GRAM domain and a coiled-coil dimerization module
Philipp Berger, Christiane Schaffitzel, Imre Berger, Nenad Ban, and Ueli Suter
Proc Natl Acad Sci U S A. 2003 October 14; 100(21): 12177–12182. Published online 2003 October 6. doi: 10.1073/pnas.2132732100.
PMCID: PMC218732
Chromatin assembly factor 1 is essential and couples chromatin assembly to DNA replication in vivo
Maarten Hoek and Bruce Stillman
Proc Natl Acad Sci U S A. 2003 October 14; 100(21): 12183–12188. Published online 2003 September 30. doi: 10.1073/pnas.1635158100.
PMCID: PMC218733
Developmental Biology
Patterning of the cardiac outflow region in Drosophila
Martina Zikova, Jean-Philippe Da Ponte, Bernard Dastugue, and Krzysztof Jagla
Proc Natl Acad Sci U S A. 2003 October 14; 100(21): 12189–12194. Published online 2003 September 30. doi: 10.1073/pnas.2133156100.
PMCID: PMC218734
From the Cover:
Sp8 is crucial for limb outgrowth and neuropore closure
Sheila M. Bell, Claire M. Schreiner, Ronald R. Waclaw, Kenneth Campbell, S. Steven Potter, and William J. Scott
Proc Natl Acad Sci U S A. 2003 October 14; 100(21): 12195–12200. Published online 2003 October 2. doi: 10.1073/pnas.2134310100.
PMCID: PMC218735
A multitude of genes expressed solely in meiotic or postmeiotic spermatogenic cells offers a myriad of contraceptive targets
Nikolaus Schultz, F. Kent Hamra, and David L. Garbers
Proc Natl Acad Sci U S A. 2003 October 14; 100(21): 12201–12206. Published online 2003 October 2. doi: 10.1073/pnas.1635054100.
PMCID: PMC218736
Reprogramming of primordial germ cells begins before migration into the genital ridge, making these cells inadequate donors for reproductive cloning
Yukiko Yamazaki, Mellissa R. W. Mann, Susan S. Lee, Joel Marh, John R. McCarrey, Ryuzo Yanagimachi, and Marisa S. Bartolomei
Proc Natl Acad Sci U S A. 2003 October 14; 100(21): 12207–12212. Published online 2003 September 23. doi: 10.1073/pnas.2035119100.
PMCID: PMC218737
Repeated neonatal handling with maternal separation permanently alters hippocampal GABAA receptors and behavioral stress responses
Fu-Chun Hsu, Guo-Jun Zhang, Yogendra Sinh H. Raol, Rita J. Valentino, Douglas A. Coulter, and Amy R. Brooks-Kayal
Proc Natl Acad Sci U S A. 2003 October 14; 100(21): 12213–12218. Published online 2003 October 6. doi: 10.1073/pnas.2131679100.
PMCID: PMC218738
Ecology
Avian migration phenology and global climate change
Peter A. Cotton
Proc Natl Acad Sci U S A. 2003 October 14; 100(21): 12219–12222. Published online 2003 September 30. doi: 10.1073/pnas.1930548100.
PMCID: PMC218739
Sequential megafaunal collapse in the North Pacific Ocean: An ongoing legacy of industrial whaling?
A. M. Springer, J. A. Estes, G. B. van Vliet, T. M. Williams, D. F. Doak, E. M. Danner, K. A. Forney, and B. Pfister
Proc Natl Acad Sci U S A. 2003 October 14; 100(21): 12223–12228. Published online 2003 October 2. doi: 10.1073/pnas.1635156100.
PMCID: PMC218740
Coastal oceanography sets the pace of rocky intertidal community dynamics
B. A. Menge, J. Lubchenco, M. E. S. Bracken, F. Chan, M. M. Foley, T. L. Freidenburg, S. D. Gaines, G. Hudson, C. Krenz, H. Leslie, D. N. L. Menge, R. Russell, and M. S. Webster
Proc Natl Acad Sci U S A. 2003 October 14; 100(21): 12229–12234. Published online 2003 September 25. doi: 10.1073/pnas.1534875100.
PMCID: PMC218741
Evolution
Evolution of olfactory receptor genes in the human genome
Yoshihito Niimura and Masatoshi Nei
Proc Natl Acad Sci U S A. 2003 October 14; 100(21): 12235–12240. Published online 2003 September 24. doi: 10.1073/pnas.1635157100.
PMCID: PMC218742
Positive selection on protein-length in the evolution of a primate sperm ion channel
Ondrej Podlaha and Jianzhi Zhang
Proc Natl Acad Sci U S A. 2003 October 14; 100(21): 12241–12246. Published online 2003 October 1. doi: 10.1073/pnas.2033555100.
PMCID: PMC218743
Genetics
Distribution of NF-κB-binding sites across human chromosome 22
Rebecca Martone, Ghia Euskirchen, Paul Bertone, Stephen Hartman, Thomas E. Royce, Nicholas M. Luscombe, John L. Rinn, F. Kenneth Nelson, Perry Miller, Mark Gerstein, Sherman Weissman, and Michael Snyder
Proc Natl Acad Sci U S A. 2003 October 14; 100(21): 12247–12252. Published online 2003 October 3. doi: 10.1073/pnas.2135255100.
PMCID: PMC218744
Predicting aberrant CpG island methylation
F. A. Feltus, E. K. Lee, J. F. Costello, C. Plass, and P. M. Vertino
Proc Natl Acad Sci U S A. 2003 October 14; 100(21): 12253–12258. Published online 2003 September 30. doi: 10.1073/pnas.2037852100.
PMCID: PMC218745
Gene expression profiling in Werner syndrome closely resembles that of normal aging
Kasper J. Kyng, Alfred May, Steen Kølvraa, and Vilhelm A. Bohr
Proc Natl Acad Sci U S A. 2003 October 14; 100(21): 12259–12264. Published online 2003 October 3. doi: 10.1073/pnas.2130723100.
PMCID: PMC218746
A complex history of rearrangement in an orthologous region of the maize, sorghum, and rice genomes
Katica Ilic, Phillip J. SanMiguel, and Jeffrey L. Bennetzen
Proc Natl Acad Sci U S A. 2003 October 14; 100(21): 12265–12270. Published online 2003 October 6. doi: 10.1073/pnas.1434476100.
PMCID: PMC218747
Highly specific zinc finger proteins obtained by directed domain shuffling and cell-based selection
Jessica A. Hurt, Stacey A. Thibodeau, Andrew S. Hirsh, Carl O. Pabo, and J. Keith Joung
Proc Natl Acad Sci U S A. 2003 October 14; 100(21): 12271–12276. Published online 2003 October 3. doi: 10.1073/pnas.2135381100.
PMCID: PMC218748
From the Cover:
Mutations in bone morphogenetic protein receptor 1B cause brachydactyly type A2
Katarina Lehmann, Petra Seemann, Sigmar Stricker, Marai Sammar, Birgit Meyer, Katrin Süring, Frank Majewski, Sigrid Tinschert, Karl-Heinz Grzeschik, Dietmar Müller, Petra Knaus, Peter Nürnberg, and Stefan Mundlos
Proc Natl Acad Sci U S A. 2003 October 14; 100(21): 12277–12282. Published online 2003 October 1. doi: 10.1073/pnas.2133476100.
PMCID: PMC218749
A strabismus susceptibility locus on chromosome 7p
Vaishali Parikh, Yin Yao Shugart, Kimberly F. Doheny, Jie Zhang, Lan Li, John Williams, David Hayden, Brian Craig, Hilda Capo, Denise Chamblee, Cathy Chen, Mary Collins, Stuart Dankner, Dean Fiergang, David Guyton, David Hunter, Marcia Hutcheon, Marshall Keys, Nancy Morrison, Michelle Munoz, Marshall Parks, David Plotsky, Eugene Protzko, Michael X. Repka, Maria Sarubbi, Bruce Schnall, R. Michael Siatkowski, Elias Traboulsi, Joanne Waeltermann, and Jeremy Nathans
Proc Natl Acad Sci U S A. 2003 October 14; 100(21): 12283–12288. Published online 2003 September 30. doi: 10.1073/pnas.2035118100.
PMCID: PMC218750
Immunology
Protective immunity against Helicobacter is characterized by a unique transcriptional signature
Anne Mueller, Jani O'Rourke, Pauline Chu, Charles C. Kim, Philip Sutton, Adrian Lee, and Stanley Falkow
Proc Natl Acad Sci U S A. 2003 October 14; 100(21): 12289–12294. Published online 2003 October 3. doi: 10.1073/pnas.1635231100.
PMCID: PMC218751
Invasion-inhibitory antibodies inhibit proteolytic processing of apical membrane antigen 1 of Plasmodium falciparum merozoites
Sheetij Dutta, J. David Haynes, J. Kathleen Moch, Arnoldo Barbosa, and David E. Lanar
Proc Natl Acad Sci U S A. 2003 October 14; 100(21): 12295–12300. Published online 2003 October 2. doi: 10.1073/pnas.2032858100.
PMCID: PMC218752
Inhibition of NF-κB by ZAS3, a zinc-finger protein that also binds to the κB motif
Joung-Woo Hong, Carl E. Allen, and Lai-Chu Wu
Proc Natl Acad Sci U S A. 2003 October 14; 100(21): 12301–12306. Published online 2003 October 6. doi: 10.1073/pnas.2133048100.
PMCID: PMC218753
Establishment of memory for IL-10 expression in developing T helper 2 cells requires repetitive IL-4 costimulation and does not impair proliferation
Max Löhning, Anne Richter, Torsten Stamm, Jane Hu-Li, Mario Assenmacher, William E. Paul, and Andreas Radbruch
Proc Natl Acad Sci U S A. 2003 October 14; 100(21): 12307–12312. Published online 2003 September 26. doi: 10.1073/pnas.2035254100.
PMCID: PMC218754
Medical Sciences
Cardiac progenitor cells from adult myocardium: Homing, differentiation, and fusion after infarction
Hidemasa Oh, Steven B. Bradfute, Teresa D. Gallardo, Teruya Nakamura, Vinciane Gaussin, Yuji Mishina, Jennifer Pocius, Lloyd H. Michael, Richard R. Behringer, Daniel J. Garry, Mark L. Entman, and Michael D. Schneider
Proc Natl Acad Sci U S A. 2003 October 14; 100(21): 12313–12318. Published online 2003 October 6. doi: 10.1073/pnas.2132126100.
PMCID: PMC218755
Systemic and cell type-specific gene expression patterns in scleroderma skin
Michael L. Whitfield, Deborah R. Finlay, John Isaac Murray, Olga G. Troyanskaya, Jen-Tsan Chi, Alexander Pergamenschikov, Timothy H. McCalmont, Patrick O. Brown, David Botstein, and M. Kari Connolly
Proc Natl Acad Sci U S A. 2003 October 14; 100(21): 12319–12324. Published online 2003 October 6. doi: 10.1073/pnas.1635114100.
PMCID: PMC218756
Disruption of PPT2 in mice causes an unusual lysosomal storage disorder with neurovisceral features
Praveena Gupta, Abigail A. Soyombo, John M. Shelton, Ian G. Wilkofsky, Krystyna E. Wisniewski, James A. Richardson, and Sandra L. Hofmann
Proc Natl Acad Sci U S A. 2003 October 14; 100(21): 12325–12330. Published online 2003 October 3. doi: 10.1073/pnas.2033229100.
PMCID: PMC218757
Induction of pulmonary hypertension by an angiopoietin 1/TIE2/serotonin pathway
Christopher C. Sullivan, Lingling Du, Danny Chu, Augustine J. Cho, Masakuni Kido, Paul L. Wolf, Stuart W. Jamieson, and Patricia A. Thistlethwaite
Proc Natl Acad Sci U S A. 2003 October 14; 100(21): 12331–12336. Published online 2003 September 25. doi: 10.1073/pnas.1933740100.
PMCID: PMC218758
Angiogenesis impairment in Id-deficient mice cooperates with an Hsp90 inhibitor to completely suppress HER2/neu-dependent breast tumors
Paola de Candia, David B. Solit, Dilip Giri, Edi Brogi, Peter M. Siegel, Adam B. Olshen, William J. Muller, Neal Rosen, and Robert Benezra
Proc Natl Acad Sci U S A. 2003 October 14; 100(21): 12337–12342. Published online 2003 October 2. doi: 10.1073/pnas.2031337100.
PMCID: PMC218759
Identification of biomarkers for ovarian cancer using strong anion-exchange ProteinChips: Potential use in diagnosis and prognosis
Katherine R. Kozak, Malaika W. Amneus, Suzanne M. Pusey, Feng Su, Mui N. Luong, Sam A. Luong, Srinivasa T. Reddy, and Robin Farias-Eisner
Proc Natl Acad Sci U S A. 2003 October 14; 100(21): 12343–12348. Published online 2003 October 1. doi: 10.1073/pnas.2033602100.
PMCID: PMC218760
Interpreting hemoglobin and water concentration, oxygen saturation, and scattering measured in vivo by near-infrared breast tomography
Subhadra Srinivasan, Brian W. Pogue, Shudong Jiang, Hamid Dehghani, Christine Kogel, Sandra Soho, Jennifer J. Gibson, Tor D. Tosteson, Steven P. Poplack, and Keith D. Paulsen
Proc Natl Acad Sci U S A. 2003 October 14; 100(21): 12349–12354. Published online 2003 September 26. doi: 10.1073/pnas.2032822100.
PMCID: PMC218761
Phosphoinositide 3-kinase(p110α) plays a critical role for the induction of physiological, but not pathological, cardiac hypertrophy
Julie R. McMullen, Tetsuo Shioi, Li Zhang, Oleg Tarnavski, Megan C. Sherwood, Peter M. Kang, and Seigo Izumo
Proc Natl Acad Sci U S A. 2003 October 14; 100(21): 12355–12360. Published online 2003 September 24. doi: 10.1073/pnas.1934654100.
PMCID: PMC218762
Unique conformation of cancer autoantigen B23 in hepatoma: A mechanism for specificity in the autoimmune response
Danielle B. Ulanet, Michael Torbenson, Chi V. Dang, Livia Casciola-Rosen, and Antony Rosen
Proc Natl Acad Sci U S A. 2003 October 14; 100(21): 12361–12366. Published online 2003 September 30. doi: 10.1073/pnas.2035245100.
PMCID: PMC218763
Soluble CD40 ligand induces β3 integrin tyrosine phosphorylation and triggers platelet activation by outside-in signaling
K. S. Srinivasa Prasad, Patrick Andre, Ming He, Ming Bao, Jeanne Manganello, and David R. Phillips
Proc Natl Acad Sci U S A. 2003 October 14; 100(21): 12367–12371. Published online 2003 September 30. doi: 10.1073/pnas.2032886100.
PMCID: PMC218764
Single-cell analysis of covalently closed circular DNA copy numbers in a hepadnavirus-infected liver
Yong-Yuan Zhang, Bai-Hua Zhang, Daniel Theele, Samuel Litwin, Eugene Toll, and Jesse Summers
Proc Natl Acad Sci U S A. 2003 October 14; 100(21): 12372–12377. Published online 2003 October 3. doi: 10.1073/pnas.2033898100.
PMCID: PMC218765
PPARγ coactivator 1β/ERR ligand 1 is an ERR protein ligand, whose expression induces a high-energy expenditure and antagonizes obesity
Yasutomi Kamei, Hiroshi Ohizumi, Yasushi Fujitani, Tomoyuki Nemoto, Toshiya Tanaka, Nobuyuki Takahashi, Teruo Kawada, Masamitsu Miyoshi, Osamu Ezaki, and Akira Kakizuka
Proc Natl Acad Sci U S A. 2003 October 14; 100(21): 12378–12383. Published online 2003 October 6. doi: 10.1073/pnas.2135217100.
PMCID: PMC218766
Y box-binding protein 1 induces resistance to oncogenic transformation by the phosphatidylinositol 3-kinase pathway
Andreas G. Bader, Katherine A. Felts, Ning Jiang, Hwai Wen Chang, and Peter K. Vogt
Proc Natl Acad Sci U S A. 2003 October 14; 100(21): 12384–12389. Published online 2003 October 6. doi: 10.1073/pnas.2135336100.
PMCID: PMC218767
The HLA-DQ2 gene dose effect in celiac disease is directly related to the magnitude and breadth of gluten-specific T cell responses
Willemijn Vader, Dariusz Stepniak, Yvonne Kooy, Luisa Mearin, Allan Thompson, Jon J. van Rood, Liesbeth Spaenij, and Frits Koning
Proc Natl Acad Sci U S A. 2003 October 14; 100(21): 12390–12395. Published online 2003 October 6. doi: 10.1073/pnas.2135229100.
PMCID: PMC218768
Microbiology
Functional map of human cytomegalovirus AD169 defined by global mutational analysis
Dong Yu, Maria C. Silva, and Thomas Shenk
Proc Natl Acad Sci U S A. 2003 October 14; 100(21): 12396–12401. Published online 2003 September 30. doi: 10.1073/pnas.1635160100.
PMCID: PMC218769
Cooperative domains define a unique host cell-targeting signal in Plasmodium falciparum-infected erythrocytes
Carlos Lopez-Estraño, Souvik Bhattacharjee, Travis Harrison, and Kasturi Haldar
Proc Natl Acad Sci U S A. 2003 October 14; 100(21): 12402–12407. Published online 2003 September 26. doi: 10.1073/pnas.2133080100.
PMCID: PMC218770
Activation of NF-κB in cells productively infected with HSV-1 depends on activated protein kinase R and plays no apparent role in blocking apoptosis
Brunella Taddeo, Ting Rong Luo, Weiran Zhang, and Bernard Roizman
Proc Natl Acad Sci U S A. 2003 October 14; 100(21): 12408–12413. Published online 2003 October 6. doi: 10.1073/pnas.2034952100.
PMCID: PMC218771
Divergent retroviral late-budding domains recruit vacuolar protein sorting factors by using alternative adaptor proteins
Juan Martin-Serrano, Anton Yaravoy, David Perez-Caballero, and Paul D. Bieniasz
Proc Natl Acad Sci U S A. 2003 October 14; 100(21): 12414–12419. Published online 2003 September 30. doi: 10.1073/pnas.2133846100.
PMCID: PMC218772
The primary mechanism of attenuation of bacillus Calmette–Guérin is a loss of secreted lytic function required for invasion of lung interstitial tissue
Tsungda Hsu, Suzanne M. Hingley-Wilson, Bing Chen, Mei Chen, Annie Z. Dai, Paul M. Morin, Carolyn B. Marks, Jeevan Padiyar, Celia Goulding, Mari Gingery, David Eisenberg, Robert G. Russell, Steven C. Derrick, Frank M. Collins, Sheldon L. Morris, C. Harold King, and William R. Jacobs, Jr.
Proc Natl Acad Sci U S A. 2003 October 14; 100(21): 12420–12425. Published online 2003 October 13. doi: 10.1073/pnas.1635213100.
PMCID: PMC218773
Toxin-induced resistance in Bacillus anthracis lethal toxin-treated macrophages
Isabelle I. Salles, Amy E. Tucker, Daniel E. Voth, and Jimmy D. Ballard
Proc Natl Acad Sci U S A. 2003 October 14; 100(21): 12426–12431. Published online 2003 September 30. doi: 10.1073/pnas.2134042100.
PMCID: PMC218774
SecA2-dependent secretion of autolytic enzymes promotes Listeria monocytogenes pathogenesis
Laurel L. Lenz, Sina Mohammadi, Aimee Geissler, and Daniel A. Portnoy
Proc Natl Acad Sci U S A. 2003 October 14; 100(21): 12432–12437. Published online 2003 October 3. doi: 10.1073/pnas.2133653100.
PMCID: PMC218775
Neuroscience
Dopamine-dependent neurodegeneration in rats induced by viral vector-mediated overexpression of the parkin target protein, CDCrel-1
Zhizhong Dong, Boris Ferger, Jean-Charles Paterna, Denise Vogel, Sven Furler, Maribel Osinde, Joram Feldon, and Hansruedi Büeler
Proc Natl Acad Sci U S A. 2003 October 14; 100(21): 12438–12443. Published online 2003 October 6. doi: 10.1073/pnas.2132992100.
PMCID: PMC218776
Gleevec inhibits β-amyloid production but not Notch cleavage
William J. Netzer, Fei Dou, Dongming Cai, Darren Veach, Stephanie Jean, Yueming Li, William G. Bornmann, Bayard Clarkson, Huaxi Xu, and Paul Greengard
Proc Natl Acad Sci U S A. 2003 October 14; 100(21): 12444–12449. Published online 2003 October 1. doi: 10.1073/pnas.1534745100.
PMCID: PMC218777
α1E-Containing Ca2+ channels are involved in synaptic plasticity
J. Breustedt, K. E. Vogt, R. J. Miller, R. A. Nicoll, and D. Schmitz
Proc Natl Acad Sci U S A. 2003 October 14; 100(21): 12450–12455. Published online 2003 September 30. doi: 10.1073/pnas.2035117100.
PMCID: PMC218778
GABA uptake into astrocytes is not associated with significant metabolic cost: Implications for brain imaging of inhibitory transmission
Jean-Yves Chatton, Luc Pellerin, and Pierre J. Magistretti
Proc Natl Acad Sci U S A. 2003 October 14; 100(21): 12456–12461. Published online 2003 October 6. doi: 10.1073/pnas.2132096100.
PMCID: PMC218779
Four-dimensional multiphoton imaging of brain entry, amyloid binding, and clearance of an amyloid-β ligand in transgenic mice
Brian J. Bacskai, Gregory A. Hickey, Jesse Skoch, Stephen T. Kajdasz, Yanming Wang, Guo-feng Huang, Chester A. Mathis, William E. Klunk, and Bradley T. Hyman
Proc Natl Acad Sci U S A. 2003 October 14; 100(21): 12462–12467. Published online 2003 September 29. doi: 10.1073/pnas.2034101100.
PMCID: PMC218780
Subpallial origin of a population of projecting pioneer neurons during corticogenesis
Javier Morante-Oria, Alan Carleton, Barbara Ortino, Eric J. Kremer, Alfonso Fairén, and Pierre-Marie Lledo
Proc Natl Acad Sci U S A. 2003 October 14; 100(21): 12468–12473. Published online 2003 October 1. doi: 10.1073/pnas.1633692100.
PMCID: PMC218781
Modular organization of directionally tuned cells in the motor cortex: Is there a short-range order?
Bagrat Amirikian and Apostolos P. Georgopoulos
Proc Natl Acad Sci U S A. 2003 October 14; 100(21): 12474–12479. Published online 2003 October 1. doi: 10.1073/pnas.2037719100.
PMCID: PMC218782
From the Cover:
Protein kinase C phosphorylation sensitizes but does not activate the capsaicin receptor transient receptor potential vanilloid 1 (TRPV1)
Gautam Bhave, Hui-Juan Hu, Kathi S. Glauner, Weiguo Zhu, Haibin Wang, D. J. Brasier, Gerry S. Oxford, and Robert W. Gereau, IV
Proc Natl Acad Sci U S A. 2003 October 14; 100(21): 12480–12485. Published online 2003 October 1. doi: 10.1073/pnas.2032100100.
PMCID: PMC218783
Visual cortex is rescued from the effects of dark rearing by overexpression of BDNF
Laura Gianfranceschi, Rosita Siciliano, Jennifer Walls, Bernardo Morales, Alfredo Kirkwood, Z. Josh Huang, Susumu Tonegawa, and Lamberto Maffei
Proc Natl Acad Sci U S A. 2003 October 14; 100(21): 12486–12491. Published online 2003 September 26. doi: 10.1073/pnas.1934836100.
PMCID: PMC218784
Multiple shifts in the representation of a motor sequence during the acquisition of skilled performance
Maria Korman, Naftali Raz, Tamar Flash, and Avi Karni
Proc Natl Acad Sci U S A. 2003 October 14; 100(21): 12492–12497. Published online 2003 October 6. doi: 10.1073/pnas.2035019100.
PMCID: PMC218785
Pharmacology
Position-specific trapping of topoisomerase II by benzo[a]pyrene diol epoxide adducts: Implications for interactions with intercalating anticancer agents
Qasim A. Khan, Glenda Kohlhagen, Richard Marshall, Caroline A. Austin, Govind P. Kalena, Heiko Kroth, Jane M. Sayer, Donald M. Jerina, and Yves Pommier
Proc Natl Acad Sci U S A. 2003 October 14; 100(21): 12498–12503. Published online 2003 October 1. doi: 10.1073/pnas.2032456100.
PMCID: PMC218786
Physiology
Regulation of nitric oxide consumption by hypoxic red blood cells
Tae H. Han, Erion Qamirani, Allyson G. Nelson, Daniel R. Hyduke, Gautam Chaudhuri, Lih Kuo, and James C. Liao
Proc Natl Acad Sci U S A. 2003 October 14; 100(21): 12504–12509. Published online 2003 October 1. doi: 10.1073/pnas.2133409100.
PMCID: PMC218787
Plant Biology
Topological analysis of a plant vacuolar Na+/H+ antiporter reveals a luminal C terminus that regulates antiporter cation selectivity
Toshio Yamaguchi, Maris P. Apse, Huazhong Shi, and Eduardo Blumwald
Proc Natl Acad Sci U S A. 2003 October 14; 100(21): 12510–12515. Published online 2003 October 6. doi: 10.1073/pnas.2034966100.
PMCID: PMC218788
Social Sciences
Economic Sciences
Information exchange and the robustness of organizational networks
Peter Sheridan Dodds, Duncan J. Watts, and Charles F. Sabel
Proc Natl Acad Sci U S A. 2003 October 14; 100(21): 12516–12521. Published online 2003 October 3. doi: 10.1073/pnas.1534702100.
PMCID: PMC218789
Corrections
Proc Natl Acad Sci U S A. 2003 October 14; 100(21): 12522–12524. Published online 2003 September 30. doi: 10.1073/pnas.1934714100.
PMCID: PMC218790
Corrects: Sonny C. Lee, et al. Bioinorganic Chemistry Special Feature: Speculative synthetic chemistry and the nitrogenase problem. Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 3595–3600.
Proc Natl Acad Sci U S A. 2003 October 14; 100(21): 12525. Published online 2003 September 30. doi: 10.1073/pnas.2135073100.
PMCID: PMC218791
Corrects: Jeffrey S. Levinton, et al. Rapid loss of genetically based resistance to metals after the cleanup of a Superfund site. Proc Natl Acad Sci U S A. 2003 August 19; 100(17): 9889–9891.
Proc Natl Acad Sci U S A. 2003 October 14; 100(21): 12526–12527. Published online 2003 September 30. doi: 10.1073/pnas.2135216100.
PMCID: PMC218792
Corrects: Paola Sebastiani, et al. Minimal haplotype tagging. Proc Natl Acad Sci U S A. 2003 August 19; 100(17): 9900–9905.
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