| | This journal provides immediate access to some articles. Commentaries Ecological subsidies alter the structure of marine communities Stephen R. Palumbi Proc Natl Acad Sci U S A. 2003 October 14; 100(21): 11927–11928. Published online 2003 October 6. doi: 10.1073/pnas.2335832100.PMCID: PMC218687 Genetic footprinting of a retroviral Gag gene suggests an important role in virus replication Alan Rein Proc Natl Acad Sci U S A. 2003 October 14; 100(21): 11929–11930. Published online 2003 October 6. doi: 10.1073/pnas.2135539100.PMCID: PMC218688 How an enzyme surmounts the activation energy barrier Richard L. Schowen Proc Natl Acad Sci U S A. 2003 October 14; 100(21): 11931–11932. Published online 2003 October 6. doi: 10.1073/pnas.2235806100.PMCID: PMC218689 The dynamics of the spread of selective visual attention Michael S. Worden and John J. Foxe Proc Natl Acad Sci U S A. 2003 October 14; 100(21): 11933–11935. Published online 2003 October 6. doi: 10.1073/pnas.2135485100.PMCID: PMC218690 Physical Sciences Applied Mathematics Matching protein structures with fuzzy alignments Richard Blankenbecler, Mattias Ohlsson, Carsten Peterson, and Markus Ringnér Proc Natl Acad Sci U S A. 2003 October 14; 100(21): 11936–11940. Published online 2003 October 2. doi: 10.1073/pnas.1635048100.PMCID: PMC218691 Coarse-grained stochastic models for tropical convection and climate Boualem Khouider, Andrew J. Majda, and Markos A. Katsoulakis Proc Natl Acad Sci U S A. 2003 October 14; 100(21): 11941–11946. Published online 2003 September 30. doi: 10.1073/pnas.1634951100.PMCID: PMC218692 Applied Physical Sciences Self-organized queuing and scale-free behavior in real escape panic Caesar Saloma, Gay Jane Perez, Giovanni Tapang, May Lim, and Cynthia Palmes-Saloma Proc Natl Acad Sci U S A. 2003 October 14; 100(21): 11947–11952. Published online 2003 September 30. doi: 10.1073/pnas.2031912100.PMCID: PMC218693 Chemistry Dewetting-induced collapse of hydrophobic particles X. Huang, C. J. Margulis, and B. J. Berne Proc Natl Acad Sci U S A. 2003 October 14; 100(21): 11953–11958. Published online 2003 September 24. doi: 10.1073/pnas.1934837100.PMCID: PMC218694 Rapid PCR amplification of minimal enediyne polyketide synthase cassettes leads to a predictive familial classification model Wen Liu, Joachim Ahlert, Qunjie Gao, Evelyn Wendt-Pienkowski, Ben Shen, and Jon S. Thorson Proc Natl Acad Sci U S A. 2003 October 14; 100(21): 11959–11963. Published online 2003 October 3. doi: 10.1073/pnas.2034291100.PMCID: PMC218695 Enzyme screening with synthetic multifunctional pores: Focus on biopolymers Nathalie Sordé, Gopal Das, and Stefan Matile Proc Natl Acad Sci U S A. 2003 October 14; 100(21): 11964–11969. Published online 2003 October 6. doi: 10.1073/pnas.2132894100.PMCID: PMC218696 Self-organization by selection: Generation of a metallosupramolecular grid architecture by selection of components in a dynamic library of ligands Jonathan R. Nitschke and Jean-Marie Lehn Proc Natl Acad Sci U S A. 2003 October 14; 100(21): 11970–11974. Published online 2003 September 29. doi: 10.1073/pnas.1534925100.PMCID: PMC218697 Mechanism and energetics of green fluorescent protein chromophore synthesis revealed by trapped intermediate structures David P. Barondeau, Christopher D. Putnam, Carey J. Kassmann, John A. Tainer, and Elizabeth D. Getzoff Proc Natl Acad Sci U S A. 2003 October 14; 100(21): 12111–12116. Published online 2003 October 1. doi: 10.1073/pnas.2133463100.PMCID: PMC218721 Geophysics Extensive regional atmospheric hydrocarbon pollution in the southwestern United States Aaron S. Katzenstein, Lambert A. Doezema, Isobel J. Simpson, Donald R. Blake, and F. Sherwood Rowland Proc Natl Acad Sci U S A. 2003 October 14; 100(21): 11975–11979. Published online 2003 October 6. doi: 10.1073/pnas.1635258100.PMCID: PMC218698 Physics Structure and function of the feed-forward loop network motif S. Mangan and U. Alon Proc Natl Acad Sci U S A. 2003 October 14; 100(21): 11980–11985. Published online 2003 October 6. doi: 10.1073/pnas.2133841100.PMCID: PMC218699 Biological Sciences Agricultural Sciences Juvenile hormone acid methyltransferase: A key regulatory enzyme for insect metamorphosis Tetsuro Shinoda and Kyo Itoyama Proc Natl Acad Sci U S A. 2003 October 14; 100(21): 11986–11991. Published online 2003 October 6. doi: 10.1073/pnas.2134232100.PMCID: PMC218700 Anthropology Rates of anterior tooth wear in Middle Pleistocene hominins from Sima de los Huesos (Sierra de Atapuerca, Spain) J. M. Bermúdez de Castro, M. Martinón-Torres, S. Sarmiento, M. Lozano, J. L. Arsuaga, and E. Carbonell Proc Natl Acad Sci U S A. 2003 October 14; 100(21): 11992–11996. Published online 2003 October 3. doi: 10.1073/pnas.2034879100.PMCID: PMC218701 Applied Biological Sciences Zinc-finger protein-targeted gene regulation: Genomewide single-gene specificity Siyuan Tan, Dmitry Guschin, Albert Davalos, Ya-Li Lee, Andrew W. Snowden, Yann Jouvenot, H. Steven Zhang, Katherine Howes, Andrew R. McNamara, Albert Lai, Chris Ullman, Lindsey Reynolds, Michael Moore, Mark Isalan, Lutz-Peter Berg, Bradley Campos, Hong Qi, S. Kaye Spratt, Casey C. Case, Carl O. Pabo, Judith Campisi, and Philip D. Gregory Proc Natl Acad Sci U S A. 2003 October 14; 100(21): 11997–12002. Published online 2003 September 26. doi: 10.1073/pnas.2035056100.PMCID: PMC218702 Biochemistry Activation domain–mediator interactions promote transcription preinitiation complex assembly on promoter DNA Greg T. Cantin, Jennitte L. Stevens, and Arnold J. Berk Proc Natl Acad Sci U S A. 2003 October 14; 100(21): 12003–12008. Published online 2003 September 23. doi: 10.1073/pnas.2035253100.PMCID: PMC218703 HdmX stimulates Hdm2-mediated ubiquitination and degradation of p53 Laëtitia K. Linares, Arnd Hengstermann, Aaron Ciechanover, Stefan Müller, and Martin Scheffner Proc Natl Acad Sci U S A. 2003 October 14; 100(21): 12009–12014. Published online 2003 September 24. doi: 10.1073/pnas.2030930100.PMCID: PMC218704 From the Cover: The near attack conformation approach to the study of the chorismate to prephenate reaction Sun Hur and Thomas C. Bruice Proc Natl Acad Sci U S A. 2003 October 14; 100(21): 12015–12020. Published online 2003 October 1. doi: 10.1073/pnas.1534873100.PMCID: PMC218705 Insights into peptide nucleic acid (PNA) structural features: The crystal structure of a d-lysine-based chiral PNA–DNA duplex Valeria Menchise, Giuseppina De Simone, Tullia Tedeschi, Roberto Corradini, Stefano Sforza, Rosangela Marchelli, Domenica Capasso, Michele Saviano, and Carlo Pedone Proc Natl Acad Sci U S A. 2003 October 14; 100(21): 12021–12026. Published online 2003 September 25. doi: 10.1073/pnas.2034746100.PMCID: PMC218706 Combined analysis of oligonucleotide microarray data from transgenic and knockout mice identifies direct SREBP target genes Jay D. Horton, Nila A. Shah, Janet A. Warrington, Norma N. Anderson, Sahng Wook Park, Michael S. Brown, and Joseph L. Goldstein Proc Natl Acad Sci U S A. 2003 October 14; 100(21): 12027–12032. Published online 2003 September 25. doi: 10.1073/pnas.1534923100.PMCID: PMC218707 Facile synthesis of site-specifically acetylated and methylated histone proteins: Reagents for evaluation of the histone code hypothesis Shu He, David Bauman, Jamaine S. Davis, Alejandra Loyola, Kenichi Nishioka, Jennifer L. Gronlund, Danny Reinberg, Fanyu Meng, Neil Kelleher, and Dewey G. McCafferty Proc Natl Acad Sci U S A. 2003 October 14; 100(21): 12033–12038. Published online 2003 October 6. doi: 10.1073/pnas.2035256100.PMCID: PMC218708 Functional map and domain structure of MET, the product of the c-met protooncogene and receptor for hepatocyte growth factor/scatter factor Ermanno Gherardi, Mark E. Youles, Ricardo N. Miguel, Tom L. Blundell, Luisa Iamele, Julian Gough, Abhishek Bandyopadhyay, Guido Hartmann, and P. Jonathan G. Butler Proc Natl Acad Sci U S A. 2003 October 14; 100(21): 12039–12044. Published online 2003 October 3. doi: 10.1073/pnas.2034936100.PMCID: PMC218709 Human uptake and incorporation of an immunogenic nonhuman dietary sialic acid Pam Tangvoranuntakul, Pascal Gagneux, Sandra Diaz, Muriel Bardor, Nissi Varki, Ajit Varki, and Elaine Muchmore Proc Natl Acad Sci U S A. 2003 October 14; 100(21): 12045–12050. Published online 2003 October 1. doi: 10.1073/pnas.2131556100.PMCID: PMC218710 Thrombomodulin allosterically modulates the activity of the anticoagulant thrombin Alireza R. Rezaie and Likui Yang Proc Natl Acad Sci U S A. 2003 October 14; 100(21): 12051–12056. Published online 2003 October 1. doi: 10.1073/pnas.2135346100.PMCID: PMC218711 The L box regulon: Lysine sensing by leader RNAs of bacterial lysine biosynthesis genes Frank J. Grundy, Susan C. Lehman, and Tina M. Henkin Proc Natl Acad Sci U S A. 2003 October 14; 100(21): 12057–12062. Published online 2003 October 1. doi: 10.1073/pnas.2133705100.PMCID: PMC218712 Nuclear localization of pyrrole–imidazole polyamide–fluorescein conjugates in cell culture Timothy P. Best, Benjamin S. Edelson, Nicholas G. Nickols, and Peter B. Dervan Proc Natl Acad Sci U S A. 2003 October 14; 100(21): 12063–12068. Published online 2003 September 30. doi: 10.1073/pnas.2035074100.PMCID: PMC218713 Nucleation-dependent conformational conversion of the Y145Stop variant of human prion protein: Structural clues for prion propagation Bishwajit Kundu, Nilesh R. Maiti, Eric M. Jones, Krystyna A. Surewicz, David L. Vanik, and Witold K. Surewicz Proc Natl Acad Sci U S A. 2003 October 14; 100(21): 12069–12074. Published online 2003 September 30. doi: 10.1073/pnas.2033281100.PMCID: PMC218714 Biosilica formation in diatoms: Characterization of native silaffin-2 and its role in silica morphogenesis Nicole Poulsen, Manfred Sumper, and Nils Kröger Proc Natl Acad Sci U S A. 2003 October 14; 100(21): 12075–12080. Published online 2003 September 24. doi: 10.1073/pnas.2035131100.PMCID: PMC218715 DcpS can act in the 5′–3′ mRNA decay pathway in addition to the 3′–5′ pathway Erwin van Dijk, Hervé Le Hir, and Bertrand Séraphin Proc Natl Acad Sci U S A. 2003 October 14; 100(21): 12081–12086. Published online 2003 October 1. doi: 10.1073/pnas.1635192100.PMCID: PMC218716 The case of the missing NO– hemoglobin: Spectral changes suggestive of heme redox reactions reflect changes in NO– heme geometry Angela Fago, Alvin L. Crumbliss, Jim Peterson, Linda L. Pearce, and Celia Bonaventura Proc Natl Acad Sci U S A. 2003 October 14; 100(21): 12087–12092. Published online 2003 September 26. doi: 10.1073/pnas.2032603100.PMCID: PMC218717 Mechanism of nucleotide incorporation opposite a thymine-thymine dimer by yeast DNA polymerase η M. Todd Washington, Louise Prakash, and Satya Prakash Proc Natl Acad Sci U S A. 2003 October 14; 100(21): 12093–12098. Published online 2003 October 3. doi: 10.1073/pnas.2134223100.PMCID: PMC218718 Biophysics Noise and stochastic resonance in voltage-gated ion channels Robert K. Adair Proc Natl Acad Sci U S A. 2003 October 14; 100(21): 12099–12104. Published online 2003 September 23. doi: 10.1073/pnas.2034447100.PMCID: PMC218719 Coupled prediction of protein secondary and tertiary structure Jens Meiler and David Baker Proc Natl Acad Sci U S A. 2003 October 14; 100(21): 12105–12110. Published online 2003 October 3. doi: 10.1073/pnas.1831973100.PMCID: PMC218720 Mechanism and energetics of green fluorescent protein chromophore synthesis revealed by trapped intermediate structures David P. Barondeau, Christopher D. Putnam, Carey J. Kassmann, John A. Tainer, and Elizabeth D. Getzoff Proc Natl Acad Sci U S A. 2003 October 14; 100(21): 12111–12116. Published online 2003 October 1. doi: 10.1073/pnas.2133463100.PMCID: PMC218721 How fast is protein hydrophobic collapse? Mourad Sadqi, Lisa J. Lapidus, and Victor Muñoz Proc Natl Acad Sci U S A. 2003 October 14; 100(21): 12117–12122. Published online 2003 October 6. doi: 10.1073/pnas.2033863100.PMCID: PMC218722 Protein complexes and functional modules in molecular networks Victor Spirin and Leonid A. Mirny Proc Natl Acad Sci U S A. 2003 October 14; 100(21): 12123–12128. Published online 2003 September 29. doi: 10.1073/pnas.2032324100.PMCID: PMC218723 Transition-path sampling of β-hairpin folding Peter G. Bolhuis Proc Natl Acad Sci U S A. 2003 October 14; 100(21): 12129–12134. Published online 2003 October 1. doi: 10.1073/pnas.1534924100.PMCID: PMC218724 Biomolecular hydration: From water dynamics to hydrodynamics Bertil Halle and Monika Davidovic Proc Natl Acad Sci U S A. 2003 October 14; 100(21): 12135–12140. Published online 2003 October 3. doi: 10.1073/pnas.2033320100.PMCID: PMC218725 Kinks, rings, and rackets in filamentous structures Adam E. Cohen and L. Mahadevan Proc Natl Acad Sci U S A. 2003 October 14; 100(21): 12141–12146. Published online 2003 October 6. doi: 10.1073/pnas.1534600100.PMCID: PMC218726 Cell Biology From the Cover: Identification of a family of cAMP response element-binding protein coactivators by genome-scale functional analysis in mammalian cells Vadim Iourgenko, Wenjun Zhang, Craig Mickanin, Ira Daly, Can Jiang, Jonathan M. Hexham, Anthony P. Orth, Loren Miraglia, Jodi Meltzer, Dan Garza, Gung-Wei Chirn, Elizabeth McWhinnie, Dalia Cohen, Joanne Skelton, Robert Terry, Yang Yu, Dale Bodian, Frank P. Buxton, Jian Zhu, Chuanzheng Song, and Mark A. Labow Proc Natl Acad Sci U S A. 2003 October 14; 100(21): 12147–12152. Published online 2003 September 23. doi: 10.1073/pnas.1932773100.PMCID: PMC218727 From the Cover: Genome-scale functional profiling of the mammalian AP-1 signaling pathway Sumit K. Chanda, Suhaila White, Anthony P. Orth, Richard Reisdorph, Loren Miraglia, Russell S. Thomas, Paul DeJesus, Daniel E. Mason, Qihong Huang, Raquel Vega, De-Hua Yu, Christian G. Nelson, Brendan M. Smith, Robert Terry, Alicia S. Linford, Yang Yu, Gung-wei Chirn, Chuanzheng Song, Mark A. Labow, Dalia Cohen, Frederick J. King, Eric C. Peters, Peter G. Schultz, Peter K. Vogt, John B. Hogenesch, and Jeremy S. Caldwell Proc Natl Acad Sci U S A. 2003 October 14; 100(21): 12153–12158. Published online 2003 September 26. doi: 10.1073/pnas.1934839100.PMCID: PMC218728 Origins of mitochondrial thymidine triphosphate: Dynamic relations to cytosolic pools Giovanna Pontarin, Lisa Gallinaro, Paola Ferraro, Peter Reichard, and Vera Bianchi Proc Natl Acad Sci U S A. 2003 October 14; 100(21): 12159–12164. Published online 2003 September 30. doi: 10.1073/pnas.1635259100.PMCID: PMC218729 Nuclear localization of 5-lipoxygenase as a determinant of leukotriene B4 synthetic capacity Ming Luo, Sandra M. Jones, Marc Peters-Golden, and Thomas G. Brock Proc Natl Acad Sci U S A. 2003 October 14; 100(21): 12165–12170. Published online 2003 October 6. doi: 10.1073/pnas.2133253100.PMCID: PMC218730 Microtubule destabilization and nuclear entry are sequential steps leading to toxicity in Huntington's disease Eugenia Trushina, Michael P. Heldebrant, Carmen M. Perez-Terzic, Ryan Bortolon, Irina V. Kovtun, John D. Badger, II, Andre Terzic, Alvaro Estévez, Anthony J. Windebank, Roy B. Dyer, Janet Yao, and Cynthia T. McMurray Proc Natl Acad Sci U S A. 2003 October 14; 100(21): 12171–12176. Published online 2003 October 3. doi: 10.1073/pnas.2034961100.PMCID: PMC218731 Membrane association of myotubularin-related protein 2 is mediated by a pleckstrin homology-GRAM domain and a coiled-coil dimerization module Philipp Berger, Christiane Schaffitzel, Imre Berger, Nenad Ban, and Ueli Suter Proc Natl Acad Sci U S A. 2003 October 14; 100(21): 12177–12182. Published online 2003 October 6. doi: 10.1073/pnas.2132732100.PMCID: PMC218732 Chromatin assembly factor 1 is essential and couples chromatin assembly to DNA replication in vivo Maarten Hoek and Bruce Stillman Proc Natl Acad Sci U S A. 2003 October 14; 100(21): 12183–12188. Published online 2003 September 30. doi: 10.1073/pnas.1635158100.PMCID: PMC218733 Developmental Biology Patterning of the cardiac outflow region in Drosophila Martina Zikova, Jean-Philippe Da Ponte, Bernard Dastugue, and Krzysztof Jagla Proc Natl Acad Sci U S A. 2003 October 14; 100(21): 12189–12194. Published online 2003 September 30. doi: 10.1073/pnas.2133156100.PMCID: PMC218734 From the Cover: Sp8 is crucial for limb outgrowth and neuropore closure Sheila M. Bell, Claire M. Schreiner, Ronald R. Waclaw, Kenneth Campbell, S. Steven Potter, and William J. Scott Proc Natl Acad Sci U S A. 2003 October 14; 100(21): 12195–12200. Published online 2003 October 2. doi: 10.1073/pnas.2134310100.PMCID: PMC218735 A multitude of genes expressed solely in meiotic or postmeiotic spermatogenic cells offers a myriad of contraceptive targets Nikolaus Schultz, F. Kent Hamra, and David L. Garbers Proc Natl Acad Sci U S A. 2003 October 14; 100(21): 12201–12206. Published online 2003 October 2. doi: 10.1073/pnas.1635054100.PMCID: PMC218736 Reprogramming of primordial germ cells begins before migration into the genital ridge, making these cells inadequate donors for reproductive cloning Yukiko Yamazaki, Mellissa R. W. Mann, Susan S. Lee, Joel Marh, John R. McCarrey, Ryuzo Yanagimachi, and Marisa S. Bartolomei Proc Natl Acad Sci U S A. 2003 October 14; 100(21): 12207–12212. Published online 2003 September 23. doi: 10.1073/pnas.2035119100.PMCID: PMC218737 Repeated neonatal handling with maternal separation permanently alters hippocampal GABAA receptors and behavioral stress responses Fu-Chun Hsu, Guo-Jun Zhang, Yogendra Sinh H. Raol, Rita J. Valentino, Douglas A. Coulter, and Amy R. Brooks-Kayal Proc Natl Acad Sci U S A. 2003 October 14; 100(21): 12213–12218. Published online 2003 October 6. doi: 10.1073/pnas.2131679100.PMCID: PMC218738 Ecology Avian migration phenology and global climate change Peter A. Cotton Proc Natl Acad Sci U S A. 2003 October 14; 100(21): 12219–12222. Published online 2003 September 30. doi: 10.1073/pnas.1930548100.PMCID: PMC218739 Sequential megafaunal collapse in the North Pacific Ocean: An ongoing legacy of industrial whaling? A. M. Springer, J. A. Estes, G. B. van Vliet, T. M. Williams, D. F. Doak, E. M. Danner, K. A. Forney, and B. Pfister Proc Natl Acad Sci U S A. 2003 October 14; 100(21): 12223–12228. Published online 2003 October 2. doi: 10.1073/pnas.1635156100.PMCID: PMC218740 Coastal oceanography sets the pace of rocky intertidal community dynamics B. A. Menge, J. Lubchenco, M. E. S. Bracken, F. Chan, M. M. Foley, T. L. Freidenburg, S. D. Gaines, G. Hudson, C. Krenz, H. Leslie, D. N. L. Menge, R. Russell, and M. S. Webster Proc Natl Acad Sci U S A. 2003 October 14; 100(21): 12229–12234. Published online 2003 September 25. doi: 10.1073/pnas.1534875100.PMCID: PMC218741 Evolution Evolution of olfactory receptor genes in the human genome Yoshihito Niimura and Masatoshi Nei Proc Natl Acad Sci U S A. 2003 October 14; 100(21): 12235–12240. Published online 2003 September 24. doi: 10.1073/pnas.1635157100.PMCID: PMC218742 Positive selection on protein-length in the evolution of a primate sperm ion channel Ondrej Podlaha and Jianzhi Zhang Proc Natl Acad Sci U S A. 2003 October 14; 100(21): 12241–12246. Published online 2003 October 1. doi: 10.1073/pnas.2033555100.PMCID: PMC218743 Genetics Distribution of NF-κB-binding sites across human chromosome 22 Rebecca Martone, Ghia Euskirchen, Paul Bertone, Stephen Hartman, Thomas E. Royce, Nicholas M. Luscombe, John L. Rinn, F. Kenneth Nelson, Perry Miller, Mark Gerstein, Sherman Weissman, and Michael Snyder Proc Natl Acad Sci U S A. 2003 October 14; 100(21): 12247–12252. Published online 2003 October 3. doi: 10.1073/pnas.2135255100.PMCID: PMC218744 Predicting aberrant CpG island methylation F. A. Feltus, E. K. Lee, J. F. Costello, C. Plass, and P. M. Vertino Proc Natl Acad Sci U S A. 2003 October 14; 100(21): 12253–12258. Published online 2003 September 30. doi: 10.1073/pnas.2037852100.PMCID: PMC218745 Gene expression profiling in Werner syndrome closely resembles that of normal aging Kasper J. Kyng, Alfred May, Steen Kølvraa, and Vilhelm A. Bohr Proc Natl Acad Sci U S A. 2003 October 14; 100(21): 12259–12264. Published online 2003 October 3. doi: 10.1073/pnas.2130723100.PMCID: PMC218746 A complex history of rearrangement in an orthologous region of the maize, sorghum, and rice genomes Katica Ilic, Phillip J. SanMiguel, and Jeffrey L. Bennetzen Proc Natl Acad Sci U S A. 2003 October 14; 100(21): 12265–12270. Published online 2003 October 6. doi: 10.1073/pnas.1434476100.PMCID: PMC218747 Highly specific zinc finger proteins obtained by directed domain shuffling and cell-based selection Jessica A. Hurt, Stacey A. Thibodeau, Andrew S. Hirsh, Carl O. Pabo, and J. Keith Joung Proc Natl Acad Sci U S A. 2003 October 14; 100(21): 12271–12276. Published online 2003 October 3. doi: 10.1073/pnas.2135381100.PMCID: PMC218748 From the Cover: Mutations in bone morphogenetic protein receptor 1B cause brachydactyly type A2 Katarina Lehmann, Petra Seemann, Sigmar Stricker, Marai Sammar, Birgit Meyer, Katrin Süring, Frank Majewski, Sigrid Tinschert, Karl-Heinz Grzeschik, Dietmar Müller, Petra Knaus, Peter Nürnberg, and Stefan Mundlos Proc Natl Acad Sci U S A. 2003 October 14; 100(21): 12277–12282. Published online 2003 October 1. doi: 10.1073/pnas.2133476100.PMCID: PMC218749 A strabismus susceptibility locus on chromosome 7p Vaishali Parikh, Yin Yao Shugart, Kimberly F. Doheny, Jie Zhang, Lan Li, John Williams, David Hayden, Brian Craig, Hilda Capo, Denise Chamblee, Cathy Chen, Mary Collins, Stuart Dankner, Dean Fiergang, David Guyton, David Hunter, Marcia Hutcheon, Marshall Keys, Nancy Morrison, Michelle Munoz, Marshall Parks, David Plotsky, Eugene Protzko, Michael X. Repka, Maria Sarubbi, Bruce Schnall, R. Michael Siatkowski, Elias Traboulsi, Joanne Waeltermann, and Jeremy Nathans Proc Natl Acad Sci U S A. 2003 October 14; 100(21): 12283–12288. Published online 2003 September 30. doi: 10.1073/pnas.2035118100.PMCID: PMC218750 Immunology Protective immunity against Helicobacter is characterized by a unique transcriptional signature Anne Mueller, Jani O'Rourke, Pauline Chu, Charles C. Kim, Philip Sutton, Adrian Lee, and Stanley Falkow Proc Natl Acad Sci U S A. 2003 October 14; 100(21): 12289–12294. Published online 2003 October 3. doi: 10.1073/pnas.1635231100.PMCID: PMC218751 Invasion-inhibitory antibodies inhibit proteolytic processing of apical membrane antigen 1 of Plasmodium falciparum merozoites Sheetij Dutta, J. David Haynes, J. Kathleen Moch, Arnoldo Barbosa, and David E. Lanar Proc Natl Acad Sci U S A. 2003 October 14; 100(21): 12295–12300. Published online 2003 October 2. doi: 10.1073/pnas.2032858100.PMCID: PMC218752 Inhibition of NF-κB by ZAS3, a zinc-finger protein that also binds to the κB motif Joung-Woo Hong, Carl E. Allen, and Lai-Chu Wu Proc Natl Acad Sci U S A. 2003 October 14; 100(21): 12301–12306. Published online 2003 October 6. doi: 10.1073/pnas.2133048100.PMCID: PMC218753 Establishment of memory for IL-10 expression in developing T helper 2 cells requires repetitive IL-4 costimulation and does not impair proliferation Max Löhning, Anne Richter, Torsten Stamm, Jane Hu-Li, Mario Assenmacher, William E. Paul, and Andreas Radbruch Proc Natl Acad Sci U S A. 2003 October 14; 100(21): 12307–12312. Published online 2003 September 26. doi: 10.1073/pnas.2035254100.PMCID: PMC218754 Medical Sciences Cardiac progenitor cells from adult myocardium: Homing, differentiation, and fusion after infarction Hidemasa Oh, Steven B. Bradfute, Teresa D. Gallardo, Teruya Nakamura, Vinciane Gaussin, Yuji Mishina, Jennifer Pocius, Lloyd H. Michael, Richard R. Behringer, Daniel J. Garry, Mark L. Entman, and Michael D. Schneider Proc Natl Acad Sci U S A. 2003 October 14; 100(21): 12313–12318. Published online 2003 October 6. doi: 10.1073/pnas.2132126100.PMCID: PMC218755 Systemic and cell type-specific gene expression patterns in scleroderma skin Michael L. Whitfield, Deborah R. Finlay, John Isaac Murray, Olga G. Troyanskaya, Jen-Tsan Chi, Alexander Pergamenschikov, Timothy H. McCalmont, Patrick O. Brown, David Botstein, and M. Kari Connolly Proc Natl Acad Sci U S A. 2003 October 14; 100(21): 12319–12324. Published online 2003 October 6. doi: 10.1073/pnas.1635114100.PMCID: PMC218756 Disruption of PPT2 in mice causes an unusual lysosomal storage disorder with neurovisceral features Praveena Gupta, Abigail A. Soyombo, John M. Shelton, Ian G. Wilkofsky, Krystyna E. Wisniewski, James A. Richardson, and Sandra L. Hofmann Proc Natl Acad Sci U S A. 2003 October 14; 100(21): 12325–12330. Published online 2003 October 3. doi: 10.1073/pnas.2033229100.PMCID: PMC218757 Induction of pulmonary hypertension by an angiopoietin 1/TIE2/serotonin pathway Christopher C. Sullivan, Lingling Du, Danny Chu, Augustine J. Cho, Masakuni Kido, Paul L. Wolf, Stuart W. Jamieson, and Patricia A. Thistlethwaite Proc Natl Acad Sci U S A. 2003 October 14; 100(21): 12331–12336. Published online 2003 September 25. doi: 10.1073/pnas.1933740100.PMCID: PMC218758 Angiogenesis impairment in Id-deficient mice cooperates with an Hsp90 inhibitor to completely suppress HER2/neu-dependent breast tumors Paola de Candia, David B. Solit, Dilip Giri, Edi Brogi, Peter M. Siegel, Adam B. Olshen, William J. Muller, Neal Rosen, and Robert Benezra Proc Natl Acad Sci U S A. 2003 October 14; 100(21): 12337–12342. Published online 2003 October 2. doi: 10.1073/pnas.2031337100.PMCID: PMC218759 Identification of biomarkers for ovarian cancer using strong anion-exchange ProteinChips: Potential use in diagnosis and prognosis Katherine R. Kozak, Malaika W. Amneus, Suzanne M. Pusey, Feng Su, Mui N. Luong, Sam A. Luong, Srinivasa T. Reddy, and Robin Farias-Eisner Proc Natl Acad Sci U S A. 2003 October 14; 100(21): 12343–12348. Published online 2003 October 1. doi: 10.1073/pnas.2033602100.PMCID: PMC218760 Interpreting hemoglobin and water concentration, oxygen saturation, and scattering measured in vivo by near-infrared breast tomography Subhadra Srinivasan, Brian W. Pogue, Shudong Jiang, Hamid Dehghani, Christine Kogel, Sandra Soho, Jennifer J. Gibson, Tor D. Tosteson, Steven P. Poplack, and Keith D. Paulsen Proc Natl Acad Sci U S A. 2003 October 14; 100(21): 12349–12354. Published online 2003 September 26. doi: 10.1073/pnas.2032822100.PMCID: PMC218761 Phosphoinositide 3-kinase(p110α) plays a critical role for the induction of physiological, but not pathological, cardiac hypertrophy Julie R. McMullen, Tetsuo Shioi, Li Zhang, Oleg Tarnavski, Megan C. Sherwood, Peter M. Kang, and Seigo Izumo Proc Natl Acad Sci U S A. 2003 October 14; 100(21): 12355–12360. Published online 2003 September 24. doi: 10.1073/pnas.1934654100.PMCID: PMC218762 Unique conformation of cancer autoantigen B23 in hepatoma: A mechanism for specificity in the autoimmune response Danielle B. Ulanet, Michael Torbenson, Chi V. Dang, Livia Casciola-Rosen, and Antony Rosen Proc Natl Acad Sci U S A. 2003 October 14; 100(21): 12361–12366. Published online 2003 September 30. doi: 10.1073/pnas.2035245100.PMCID: PMC218763 Soluble CD40 ligand induces β3 integrin tyrosine phosphorylation and triggers platelet activation by outside-in signaling K. S. Srinivasa Prasad, Patrick Andre, Ming He, Ming Bao, Jeanne Manganello, and David R. Phillips Proc Natl Acad Sci U S A. 2003 October 14; 100(21): 12367–12371. Published online 2003 September 30. doi: 10.1073/pnas.2032886100.PMCID: PMC218764 Single-cell analysis of covalently closed circular DNA copy numbers in a hepadnavirus-infected liver Yong-Yuan Zhang, Bai-Hua Zhang, Daniel Theele, Samuel Litwin, Eugene Toll, and Jesse Summers Proc Natl Acad Sci U S A. 2003 October 14; 100(21): 12372–12377. Published online 2003 October 3. doi: 10.1073/pnas.2033898100.PMCID: PMC218765 PPARγ coactivator 1β/ERR ligand 1 is an ERR protein ligand, whose expression induces a high-energy expenditure and antagonizes obesity Yasutomi Kamei, Hiroshi Ohizumi, Yasushi Fujitani, Tomoyuki Nemoto, Toshiya Tanaka, Nobuyuki Takahashi, Teruo Kawada, Masamitsu Miyoshi, Osamu Ezaki, and Akira Kakizuka Proc Natl Acad Sci U S A. 2003 October 14; 100(21): 12378–12383. Published online 2003 October 6. doi: 10.1073/pnas.2135217100.PMCID: PMC218766 Y box-binding protein 1 induces resistance to oncogenic transformation by the phosphatidylinositol 3-kinase pathway Andreas G. Bader, Katherine A. Felts, Ning Jiang, Hwai Wen Chang, and Peter K. Vogt Proc Natl Acad Sci U S A. 2003 October 14; 100(21): 12384–12389. Published online 2003 October 6. doi: 10.1073/pnas.2135336100.PMCID: PMC218767 The HLA-DQ2 gene dose effect in celiac disease is directly related to the magnitude and breadth of gluten-specific T cell responses Willemijn Vader, Dariusz Stepniak, Yvonne Kooy, Luisa Mearin, Allan Thompson, Jon J. van Rood, Liesbeth Spaenij, and Frits Koning Proc Natl Acad Sci U S A. 2003 October 14; 100(21): 12390–12395. Published online 2003 October 6. doi: 10.1073/pnas.2135229100.PMCID: PMC218768 Microbiology Functional map of human cytomegalovirus AD169 defined by global mutational analysis Dong Yu, Maria C. Silva, and Thomas Shenk Proc Natl Acad Sci U S A. 2003 October 14; 100(21): 12396–12401. Published online 2003 September 30. doi: 10.1073/pnas.1635160100.PMCID: PMC218769 Cooperative domains define a unique host cell-targeting signal in Plasmodium falciparum-infected erythrocytes Carlos Lopez-Estraño, Souvik Bhattacharjee, Travis Harrison, and Kasturi Haldar Proc Natl Acad Sci U S A. 2003 October 14; 100(21): 12402–12407. Published online 2003 September 26. doi: 10.1073/pnas.2133080100.PMCID: PMC218770 Activation of NF-κB in cells productively infected with HSV-1 depends on activated protein kinase R and plays no apparent role in blocking apoptosis Brunella Taddeo, Ting Rong Luo, Weiran Zhang, and Bernard Roizman Proc Natl Acad Sci U S A. 2003 October 14; 100(21): 12408–12413. Published online 2003 October 6. doi: 10.1073/pnas.2034952100.PMCID: PMC218771 Divergent retroviral late-budding domains recruit vacuolar protein sorting factors by using alternative adaptor proteins Juan Martin-Serrano, Anton Yaravoy, David Perez-Caballero, and Paul D. Bieniasz Proc Natl Acad Sci U S A. 2003 October 14; 100(21): 12414–12419. Published online 2003 September 30. doi: 10.1073/pnas.2133846100.PMCID: PMC218772 The primary mechanism of attenuation of bacillus Calmette–Guérin is a loss of secreted lytic function required for invasion of lung interstitial tissue Tsungda Hsu, Suzanne M. Hingley-Wilson, Bing Chen, Mei Chen, Annie Z. Dai, Paul M. Morin, Carolyn B. Marks, Jeevan Padiyar, Celia Goulding, Mari Gingery, David Eisenberg, Robert G. Russell, Steven C. Derrick, Frank M. Collins, Sheldon L. Morris, C. Harold King, and William R. Jacobs, Jr. Proc Natl Acad Sci U S A. 2003 October 14; 100(21): 12420–12425. Published online 2003 October 13. doi: 10.1073/pnas.1635213100.PMCID: PMC218773 Toxin-induced resistance in Bacillus anthracis lethal toxin-treated macrophages Isabelle I. Salles, Amy E. Tucker, Daniel E. Voth, and Jimmy D. Ballard Proc Natl Acad Sci U S A. 2003 October 14; 100(21): 12426–12431. Published online 2003 September 30. doi: 10.1073/pnas.2134042100.PMCID: PMC218774 SecA2-dependent secretion of autolytic enzymes promotes Listeria monocytogenes pathogenesis Laurel L. Lenz, Sina Mohammadi, Aimee Geissler, and Daniel A. Portnoy Proc Natl Acad Sci U S A. 2003 October 14; 100(21): 12432–12437. Published online 2003 October 3. doi: 10.1073/pnas.2133653100.PMCID: PMC218775 Neuroscience Dopamine-dependent neurodegeneration in rats induced by viral vector-mediated overexpression of the parkin target protein, CDCrel-1 Zhizhong Dong, Boris Ferger, Jean-Charles Paterna, Denise Vogel, Sven Furler, Maribel Osinde, Joram Feldon, and Hansruedi Büeler Proc Natl Acad Sci U S A. 2003 October 14; 100(21): 12438–12443. Published online 2003 October 6. doi: 10.1073/pnas.2132992100.PMCID: PMC218776 Gleevec inhibits β-amyloid production but not Notch cleavage William J. Netzer, Fei Dou, Dongming Cai, Darren Veach, Stephanie Jean, Yueming Li, William G. Bornmann, Bayard Clarkson, Huaxi Xu, and Paul Greengard Proc Natl Acad Sci U S A. 2003 October 14; 100(21): 12444–12449. Published online 2003 October 1. doi: 10.1073/pnas.1534745100.PMCID: PMC218777 α1E-Containing Ca2+ channels are involved in synaptic plasticity J. Breustedt, K. E. Vogt, R. J. Miller, R. A. Nicoll, and D. Schmitz Proc Natl Acad Sci U S A. 2003 October 14; 100(21): 12450–12455. Published online 2003 September 30. doi: 10.1073/pnas.2035117100.PMCID: PMC218778 GABA uptake into astrocytes is not associated with significant metabolic cost: Implications for brain imaging of inhibitory transmission Jean-Yves Chatton, Luc Pellerin, and Pierre J. Magistretti Proc Natl Acad Sci U S A. 2003 October 14; 100(21): 12456–12461. Published online 2003 October 6. doi: 10.1073/pnas.2132096100.PMCID: PMC218779 Four-dimensional multiphoton imaging of brain entry, amyloid binding, and clearance of an amyloid-β ligand in transgenic mice Brian J. Bacskai, Gregory A. Hickey, Jesse Skoch, Stephen T. Kajdasz, Yanming Wang, Guo-feng Huang, Chester A. Mathis, William E. Klunk, and Bradley T. Hyman Proc Natl Acad Sci U S A. 2003 October 14; 100(21): 12462–12467. Published online 2003 September 29. doi: 10.1073/pnas.2034101100.PMCID: PMC218780 Subpallial origin of a population of projecting pioneer neurons during corticogenesis Javier Morante-Oria, Alan Carleton, Barbara Ortino, Eric J. Kremer, Alfonso Fairén, and Pierre-Marie Lledo Proc Natl Acad Sci U S A. 2003 October 14; 100(21): 12468–12473. Published online 2003 October 1. doi: 10.1073/pnas.1633692100.PMCID: PMC218781 Modular organization of directionally tuned cells in the motor cortex: Is there a short-range order? Bagrat Amirikian and Apostolos P. Georgopoulos Proc Natl Acad Sci U S A. 2003 October 14; 100(21): 12474–12479. Published online 2003 October 1. doi: 10.1073/pnas.2037719100.PMCID: PMC218782 From the Cover: Protein kinase C phosphorylation sensitizes but does not activate the capsaicin receptor transient receptor potential vanilloid 1 (TRPV1) Gautam Bhave, Hui-Juan Hu, Kathi S. Glauner, Weiguo Zhu, Haibin Wang, D. J. Brasier, Gerry S. Oxford, and Robert W. Gereau, IV Proc Natl Acad Sci U S A. 2003 October 14; 100(21): 12480–12485. Published online 2003 October 1. doi: 10.1073/pnas.2032100100.PMCID: PMC218783 Visual cortex is rescued from the effects of dark rearing by overexpression of BDNF Laura Gianfranceschi, Rosita Siciliano, Jennifer Walls, Bernardo Morales, Alfredo Kirkwood, Z. Josh Huang, Susumu Tonegawa, and Lamberto Maffei Proc Natl Acad Sci U S A. 2003 October 14; 100(21): 12486–12491. Published online 2003 September 26. doi: 10.1073/pnas.1934836100.PMCID: PMC218784 Multiple shifts in the representation of a motor sequence during the acquisition of skilled performance Maria Korman, Naftali Raz, Tamar Flash, and Avi Karni Proc Natl Acad Sci U S A. 2003 October 14; 100(21): 12492–12497. Published online 2003 October 6. doi: 10.1073/pnas.2035019100.PMCID: PMC218785 Pharmacology Position-specific trapping of topoisomerase II by benzo[a]pyrene diol epoxide adducts: Implications for interactions with intercalating anticancer agents Qasim A. Khan, Glenda Kohlhagen, Richard Marshall, Caroline A. Austin, Govind P. Kalena, Heiko Kroth, Jane M. Sayer, Donald M. Jerina, and Yves Pommier Proc Natl Acad Sci U S A. 2003 October 14; 100(21): 12498–12503. Published online 2003 October 1. doi: 10.1073/pnas.2032456100.PMCID: PMC218786 Physiology Regulation of nitric oxide consumption by hypoxic red blood cells Tae H. Han, Erion Qamirani, Allyson G. Nelson, Daniel R. Hyduke, Gautam Chaudhuri, Lih Kuo, and James C. Liao Proc Natl Acad Sci U S A. 2003 October 14; 100(21): 12504–12509. Published online 2003 October 1. doi: 10.1073/pnas.2133409100.PMCID: PMC218787 Plant Biology Topological analysis of a plant vacuolar Na+/H+ antiporter reveals a luminal C terminus that regulates antiporter cation selectivity Toshio Yamaguchi, Maris P. Apse, Huazhong Shi, and Eduardo Blumwald Proc Natl Acad Sci U S A. 2003 October 14; 100(21): 12510–12515. Published online 2003 October 6. doi: 10.1073/pnas.2034966100.PMCID: PMC218788 Social Sciences Economic Sciences Information exchange and the robustness of organizational networks Peter Sheridan Dodds, Duncan J. Watts, and Charles F. Sabel Proc Natl Acad Sci U S A. 2003 October 14; 100(21): 12516–12521. Published online 2003 October 3. doi: 10.1073/pnas.1534702100.PMCID: PMC218789 Corrections Proc Natl Acad Sci U S A. 2003 October 14; 100(21): 12522–12524. Published online 2003 September 30. doi: 10.1073/pnas.1934714100.PMCID: PMC218790 Corrects: Sonny C. Lee, et al. Bioinorganic Chemistry Special Feature: Speculative synthetic chemistry and the nitrogenase problem. Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 3595–3600. Proc Natl Acad Sci U S A. 2003 October 14; 100(21): 12525. Published online 2003 September 30. doi: 10.1073/pnas.2135073100.PMCID: PMC218791 Corrects: Jeffrey S. Levinton, et al. Rapid loss of genetically based resistance to metals after the cleanup of
a Superfund site. Proc Natl Acad Sci U S A. 2003 August 19; 100(17): 9889–9891. Proc Natl Acad Sci U S A. 2003 October 14; 100(21): 12526–12527. Published online 2003 September 30. doi: 10.1073/pnas.2135216100.PMCID: PMC218792 Corrects: Paola Sebastiani, et al. Minimal haplotype tagging. Proc Natl Acad Sci U S A. 2003 August 19; 100(17): 9900–9905. |