| | This journal provides immediate access to some articles. Commentaries Phenylketonuria: Old disease, new approach to treatment Harvey L. Levy PMCID: PMC33523 What sets the TonE during osmotic stress? Dietmar Kültz and Laszlo Csonka PMCID: PMC33524 Mitochondria and dystonia: The movement disorder connection? Douglas C. Wallace and Deborah G. Murdock PMCID: PMC33525 Engineering of bacterial ribosomes: Replacement of all seven
Escherichia coli rRNA operons by a single
plasmid-encoded operon Masayasu Nomura PMCID: PMC33526 DNA secondary structure: A common and causative factor for expansion in
human disease Cynthia T. McMurray PMCID: PMC33527 Borrowing to make ends meet Jon Clardy PMCID: PMC33528 Physical Sciences Applied Mathematics INAUGURAL ARTICLE by a Recently Elected Academy Member: Tight frames of k-plane ridgelets and the problem of representing objects that are smooth away from d-dimensional singularities in R nDavid L. Donoho PMCID: PMC26696 Engineering Nonlinear indicial response of complex nonstationary oscillations as pulmonary hypertension responding to step hypoxia Wei Huang, Zheng Shen, Norden E. Huang, and Yuan Cheng Fung PMCID: PMC26697 Biological Sciences Agricultural Sciences Overexpression of the Bacillus thuringiensis (Bt) Cry2Aa2 protein in chloroplasts confers resistance to plants against susceptible and Bt-resistant insects Madhuri Kota, Henry Daniell, Sam Varma, Stephen F. Garczynski, Fred Gould, and William J. Moar PMCID: PMC26698 Applied Biological Sciences Multiple genetic modifications of the erythromycin polyketide synthase to produce a library of novel “unnatural” natural products Robert McDaniel, Arinthip Thamchaipenet, Claes Gustafsson, Hong Fu, Melanie Betlach, Mary Betlach, and Gary Ashley PMCID: PMC26699 Biochemistry Unexpected crucial role of residue 225 in serine proteases Enriqueta R. Guinto, Sonia Caccia, Thierry Rose, Klaus Fütterer, Gabriel Waksman, and Enrico Di Cera PMCID: PMC26700 Proteasome-dependent degradation of the human estrogen receptor Zafar Nawaz, David M. Lonard, Andrew P. Dennis, Carolyn L. Smith, and Bert W. O’Malley PMCID: PMC26701 Structure of a cytochrome P450–redox partner electron-transfer complex Irina F. Sevrioukova, Huiying Li, Hong Zhang, Julian A. Peterson, and Thomas L. Poulos PMCID: PMC26702 Studies on the interactions between human replication factor C and human proliferating cell nuclear antigen Gang Zhang, Emma Gibbs, Zvi Kelman, Michael O’Donnell, and Jerard Hurwitz PMCID: PMC26703 p53-induced DNA bending and twisting: p53 tetramer binds on the outer side of a DNA loop and increases DNA twisting Akhilesh K. Nagaich, Victor B. Zhurkin, Stewart R. Durell, Robert L. Jernigan, Ettore Appella, and Rodney E. Harrington PMCID: PMC26704 Interaction of 5-lipoxygenase with cellular proteins Patrick Provost, Bengt Samuelsson, and Olof Rådmark PMCID: PMC26705 tRNAVal-heterodimeric maxizymes with high potential as geneinactivating agents: Simultaneous cleavage at two sites in HIV-1 tat mRNA in cultured cells Tomoko Kuwabara, Masaki Warashina, Aya Nakayama, Jun Ohkawa, and Kazunari Taira PMCID: PMC26706 Fibroblast growth factors 1 and 2 are distinct in oligomerization in the presence of heparin-like glycosaminoglycans Ganesh Venkataraman, Zachary Shriver, Joseph C. Davis, and Ram Sasisekharan PMCID: PMC26707 Small antibody-like proteins with prescribed ligand specificities derived from the lipocalin fold Gerald Beste, Frank S. Schmidt, Thomas Stibora, and Arne Skerra PMCID: PMC26708 Angiopoietins 3 and 4: Diverging gene counterparts in mice and humans David M. Valenzuela, Jennifer A. Griffiths, Jose Rojas, Thomas H. Aldrich, Pamela F. Jones, Hao Zhou, Joyce McClain, Neal G. Copeland, Debra J. Gilbert, Nancy A. Jenkins, Tammy Huang, Nick Papadopoulos, Peter C. Maisonpierre, Samuel Davis, and George D. Yancopoulos PMCID: PMC26709 Selenium redox biochemistry of zinc–sulfur coordination sites in proteins and enzymes Claus Jacob, Wolfgang Maret, and Bert L. Vallee PMCID: PMC26710 Native display of complete foreign protein domains on the surface of hepatitis B virus capsids Peter A. Kratz, Bettina Böttcher, and Michael Nassal PMCID: PMC26711 Nuclear foci of mammalian recombination proteins are located at single-stranded DNA regions formed after DNA damage Elke Raderschall, Efim I. Golub, and Thomas Haaf PMCID: PMC26712 Structure and function in rhodopsin: Kinetic studies of retinal binding to purified opsin mutants in defined phospholipid–detergent mixtures serve as probes of the retinal binding pocket Philip J. Reeves, John Hwa, and H. Gobind Khorana PMCID: PMC26713 Structure and function in rhodopsin: Further elucidation of the role of the intradiscal cysteines, Cys-110, -185, and -187, in rhodopsin folding and function John Hwa, Philip J. Reeves, Judith Klein-Seetharaman, Florence Davidson, and H. Gobind Khorana PMCID: PMC26714 Inhibitory sites in enzymes: Zinc removal and reactivation by thionein Wolfgang Maret, Claus Jacob, Bert L. Vallee, and Edmond H. Fischer PMCID: PMC26715 Mg-chelatase of tobacco: The role of the subunit CHL D in the chelation step of protoporphyrin IX Susanna Gräfe, Hans-Peter Saluz, Bernhard Grimm, and Frank Hänel PMCID: PMC26716 The GTPase activating factor for transducin in rod photoreceptors is the complex between RGS9 and type 5 G protein β subunit Elina R. Makino, Jason W. Handy, Tiansen Li, and Vadim Y. Arshavsky PMCID: PMC26717 Affinity modulation of small-molecule ligands by borrowing endogenous protein surfaces Roger Briesewitz, Gregory T. Ray, Thomas J. Wandless, and Gerald R. Crabtree PMCID: PMC26718 Thyroid hormone receptor-associated proteins and general positive cofactors mediate thyroid hormone receptor function in the absence of the TATA box-binding protein-associated factors of TFIID Joseph D. Fondell, Mohamed Guermah, Sohail Malik, and Robert G. Roeder PMCID: PMC26719 The crayfish plasma clotting protein: A vitellogenin-related protein responsible for clot formation in crustacean blood Martin Hall, Ruigong Wang, Rik van Antwerpen, Lars Sottrup-Jensen, and Kenneth Söderhäll PMCID: PMC26720 An Escherichia coli strain with all
chromosomal rRNA operons inactivated: Complete exchange of rRNA genes
between bacteria Tsuneaki Asai, Dmitry Zaporojets, Craig Squires, and Catherine L. Squires PMCID: PMC26721 Cytochrome P450 CYP1B1 determines susceptibility to 7,12-dimethylbenz[a]anthracene-induced lymphomas Jeroen T. M. Buters, Shuichi Sakai, Thomas Richter, Thierry Pineau, David L. Alexander, Uzen Savas, Johannes Doehmer, Jerrold M. Ward, Colin R. Jefcoate, and Frank J. Gonzalez PMCID: PMC26722 Tolerance of Arc repressor to multiple-alanine substitutions Bronwen M. Brown and Robert T. Sauer PMCID: PMC26723 Direct interaction of lignin and lignin peroxidase from Phanerochaete chrysosporium Toru Johjima, Noriyuki Itoh, Mari Kabuto, Fusayo Tokimura, Tamon Nakagawa, Hiroyuki Wariishi, and Hiroo Tanaka PMCID: PMC26724 Ligand-dependent activation of transcription in
vitro by retinoic acid receptor α/retinoid X receptor α
heterodimers that mimics transactivation by retinoids
in vivo F. Jeffrey Dilworth, Catherine Fromental-Ramain, Eumorphia Remboutsika, Arndt Benecke, and Pierre Chambon PMCID: PMC26725 The vacuolating toxin from Helicobacter pylori forms hexameric pores in lipid bilayers at low pH Daniel M. Czajkowsky, Hideki Iwamoto, Timothy L. Cover, and Zhifeng Shao PMCID: PMC26726 Specificity of native-like interhelical hydrophobic contacts in the apomyoglobin intermediate Michael S. Kay, Carlos H. I. Ramos, and Robert L. Baldwin PMCID: PMC26727 Cryptocyanin, a crustacean molting protein: Evolutionary link with arthropod hemocyanins and insect hexamerins Nora B. Terwilliger, Lawrence Dangott, and Margaret Ryan PMCID: PMC26728 Biophysics A specific transition state for S-peptide combining with folded S-protein and then refolding Jonathan M. Goldberg and Robert L. Baldwin PMCID: PMC26729 Energy-based de novo protein folding by conformational space annealing and an off-lattice united-residue force field: Application to the 10-55 fragment of staphylococcal protein A and to apo calbindin D9K Jooyoung Lee, Adam Liwo, and Harold A. Scheraga PMCID: PMC26730 Stretching lattice models of protein folding Nicholas D. Socci, José Nelson Onuchic, and Peter G. Wolynes PMCID: PMC26731 The two-dimensional IR nonlinear spectroscopy of a cyclic
penta-peptide in relation to its three-dimensional structure Peter Hamm, Manho Lim, William F. DeGrado, and Robin M. Hochstrasser PMCID: PMC26732 Copper binding to the prion protein: Structural implications of four identical cooperative binding sites John H. Viles, Fred E. Cohen, Stanley B. Prusiner, David B. Goodin, Peter E. Wright, and H. Jane Dyson PMCID: PMC26733 Protrusive growth from giant liposomes driven by actin polymerization Hidetake Miyata, Shuji Nishiyama, Ken-ichirou Akashi, and Kazuhiko Kinosita, Jr. PMCID: PMC26734 Multiple pathways for ultrafast transduction of light energy in the photosynthetic reaction center of Rhodobacter sphaeroides Marion E. van Brederode, Frank van Mourik, Ivo H. M. van Stokkum, Michael R. Jones, and Rienk van Grondelle PMCID: PMC26735 Cell Biology Mouse trp2, the homologue of the human trpc2 pseudogene, encodes mTrp2, a store depletion-activated capacitative Ca2+ entry channel Brigitte Vannier, Michael Peyton, Gulain Boulay, Darren Brown, Ning Qin, Meisheng Jiang, Xi Zhu, and Lutz Birnbaumer PMCID: PMC26736 Tumor suppression in human skin carcinoma cells by chromosome 15 transfer or thrombospondin-1 overexpression through halted tumor vascularization Kerstin Bleuel, Susanne Popp, Norbert E. Fusenig, Eric J. Stanbridge, and Petra Boukamp PMCID: PMC26737 The conserved SOCS box motif in suppressors of cytokine signaling binds to elongins B and C and may couple bound proteins to proteasomal degradation Jian-Guo Zhang, Alison Farley, Sandra E. Nicholson, Tracy A. Willson, Lisa M. Zugaro, Richard J. Simpson, Robert L. Moritz, Dale Cary, Rachael Richardson, George Hausmann, Benjamin J. Kile, Stephen B. H. Kent, Warren S. Alexander, Donald Metcalf, Douglas J. Hilton, Nicos A. Nicola, and Manuel Baca PMCID: PMC26738 Myogenic signaling of phosphatidylinositol 3-kinase requires the serine-threonine kinase Akt/protein kinase B Bing-Hua Jiang, Masahiro Aoki, Jenny Z. Zheng, Jian Li, and Peter K. Vogt PMCID: PMC26739 Interferon-induced human MxA GTPase blocks nuclear import of Thogoto virus nucleocapsids Georg Kochs and Otto Haller PMCID: PMC26740 Adhesion to fibronectin stimulates proliferation of wild-type and bcr/abl-transfected murine hematopoietic cells Alwin Krämer, Susanne Hörner, Andreas Willer, Stefan Fruehauf, Andreas Hochhaus, Michael Hallek, and Rüdiger Hehlmann PMCID: PMC26741 The cellular ecology of progressive neoplastic transformation: A clonal analysis Ming Chow and Harry Rubin PMCID: PMC26742 Functional integrity of mitochondrial genomes in human platelets and autopsied brain tissues from elderly patients with Alzheimer’s disease Sayaka Ito, Shigeo Ohta, Kiyomi Nishimaki, Yasuo Kagawa, Rika Soma, Shin-ya Kuno, Yasuko Komatsuzaki, Hidehiro Mizusawa, and Jun-Ichi Hayashi PMCID: PMC26743 Immunophilins, Refsum disease, and lupus nephritis: The peroxisomal enzyme phytanoyl-COA α-hydroxylase is a new FKBP-associated protein Béatrice Chambraud, Christine Radanyi, Jacques H. Camonis, Krzysztof Rajkowski, Michael Schumacher, and Etienne-Emile Baulieu PMCID: PMC26744 Regulation of G1 progression by the PTEN tumor suppressor protein is linked to inhibition of the phosphatidylinositol 3-kinase/Akt pathway Shivapriya Ramaswamy, Noriaki Nakamura, Francisca Vazquez, David B. Batt, Sauni Perera, Thomas M. Roberts, and William R. Sellers PMCID: PMC26745 Human PEX19: cDNA cloning by functional complementation, mutation analysis in a patient with Zellweger syndrome, and potential role in peroxisomal membrane assembly Yuji Matsuzono, Naohiko Kinoshita, Shigehiko Tamura, Nobuyuki Shimozawa, Maho Hamasaki, Kamran Ghaedi, Ronald J. A. Wanders, Yasuyuki Suzuki, Naomi Kondo, and Yukio Fujiki PMCID: PMC26746 INAUGURAL ARTICLE by a Recently Elected Academy Member: The small GTPase RalA targets filamin to induce filopodia Yasutaka Ohta, Nobuchika Suzuki, Shun Nakamura, John H. Hartwig, and Thomas P. Stossel PMCID: PMC26747 The RD114/simian type D retrovirus receptor is a neutral amino acid transporter John E. J. Rasko, Jean-Luc Battini, Rebecca J. Gottschalk, Ilya Mazo, and A. Dusty Miller PMCID: PMC26748 Dynamic and quantitative Ca2+ measurements using improved cameleons Atsushi Miyawaki, Oliver Griesbeck, Roger Heim, and Roger Y. Tsien PMCID: PMC26749 Human deafness dystonia syndrome is a mitochondrial disease Carla M. Koehler, Danielle Leuenberger, Sabeeha Merchant, Anja Renold, Tina Junne, and Gottfried Schatz PMCID: PMC26750 p53 regulates a G2 checkpoint through cyclin B1 Steven A. Innocente, John L. A. Abrahamson, John P. Cogswell, and Jonathan M. Lee PMCID: PMC26751 Dynamics and elasticity of the fibronectin matrix in living cell culture visualized by fibronectin–green fluorescent protein Tomoo Ohashi, Daniel P. Kiehart, and Harold P. Erickson PMCID: PMC26752 Developmental Biology In vitro hematopoietic and endothelial potential of flk-1−/− embryonic stem cells and embryos Andre C. Schuh, Patrick Faloon, Qing-Long Hu, Munsif Bhimani, and Kyunghee Choi PMCID: PMC26753 Conservation of the expression and function of apterous orthologs in Drosophila and mammals Diego E. Rincón-Limas, Cheng-Hsin Lu, Inmaculada Canal, Manuel Calleja, Concepción Rodríguez-Esteban, Juan Carlos Izpisúa-Belmonte, and Juan Botas PMCID: PMC26754 Evolution Spontaneous heterosis in larval life-history traits of hemiclonal frog hybrids Hansjürg Hotz, Raymond D. Semlitsch, Eva Gutmann, Gaston-Denis Guex, and Peter Beerli PMCID: PMC26755 Molecular studies suggest that cartilaginous fishes have a terminal position in the piscine tree Ann-Sofie Rasmussen and Ulfur Arnason PMCID: PMC26756 Expression of a Hox gene, Cnox-2, and the division of labor in a colonial hydroid Paulyn Cartwright, Julia Bowsher, and Leo W. Buss PMCID: PMC26757 Coalescent estimates of HIV-1 generation time in vivo Allen G. Rodrigo, Eugene G. Shpaer, Eric L. Delwart, Astrid K. N. Iversen, Michael V. Gallo, Jürgen Brojatsch, Martin S. Hirsch, Bruce D. Walker, and James I. Mullins PMCID: PMC26758 Evolutionary relationships among diverse bacteriophages and prophages: All the world’s a phage Roger W. Hendrix, Margaret C. M. Smith, R. Neil Burns, Michael E. Ford, and Graham F. Hatfull PMCID: PMC26759 Prehistoric birds from New Ireland, Papua New Guinea: Extinctions on a large Melanesian island David W. Steadman, J. Peter White, and Jim Allen PMCID: PMC26825 Genetics Type 2 diabetes: Evidence for linkage on chromosome 20 in 716 Finnish affected sib pairs Soumitra Ghosh, Richard M. Watanabe, Elizabeth R. Hauser, Timo Valle, Victoria L. Magnuson, Michael R. Erdos, Carl D. Langefeld, James Balow, Jr., Delphine S. Ally, Kimmo Kohtamaki, Peter Chines, Gunther Birznieks, Hong-Shi Kaleta, Anjene Musick, Catherine Te, Joyce Tannenbaum, William Eldridge, Shane Shapiro, Colin Martin, Alyson Witt, Alistair So, Jennie Chang, Ben Shurtleff, Rachel Porter, Kristina Kudelko, Arun Unni, Leonid Segal, Ravi Sharaf, Jillian Blaschak-Harvan, Johan Eriksson, Tuula Tenkula, Gabriele Vidgren, Christian Ehnholm, Eva Tuomilehto-Wolf, William Hagopian, Thomas A. Buchanan, Jaakko Tuomilehto, Richard N. Bergman, Francis S. Collins, and Michael Boehnke PMCID: PMC26760 Yeast and human genes that affect the Escherichia coli SOS response Edward L. Perkins, Joan F. Sterling, Vera I. Hashem, and Michael A. Resnick PMCID: PMC26761 Localization of non-Mhc collagen-induced arthritis susceptibility loci in DBA/1j mice Richard A. McIndoe, Beverly Bohlman, Emil Chi, Eugene Schuster, Molly Lindhardt, and Leroy Hood PMCID: PMC26762 Immunology Conformational changes in tertiary structure near the ligand binding site of an integrin I domain Claus Oxvig, Chafen Lu, and Timothy A. Springer PMCID: PMC26763 In situ detection of activated Bruton’s tyrosine kinase in the Ig signaling complex by phosphopeptide-specific monoclonal antibodies Sazuku Nisitani, Roberta M. Kato, David J. Rawlings, Owen N. Witte, and Matthew I. Wahl PMCID: PMC26764 Terreic acid, a quinone epoxide inhibitor of Bruton’s tyrosine kinase Yuko Kawakami, Stephen E. Hartman, Eiji Kinoshita, Hidefumi Suzuki, Jiro Kitaura, Libo Yao, Naoki Inagaki, Alessandra Franco, Daisuke Hata, Mari Maeda-Yamamoto, Hiromi Fukamachi, Hiroichi Nagai, and Toshiaki Kawakami PMCID: PMC26765 Immune surveillance against a solid tumor fails because of immunological ignorance Adrian F. Ochsenbein, Paul Klenerman, Urs Karrer, Burkhard Ludewig, Marcus Pericin, Hans Hengartner, and Rolf M. Zinkernagel PMCID: PMC26766 Induction of Ig light chain gene rearrangement in heavy chain-deficient B cells by activated Ras Albert C. Shaw, Wojciech Swat, Laurie Davidson, and Frederick W. Alt PMCID: PMC26767 Efficient IgG-mediated suppression of primary antibody responses in Fcγ receptor-deficient mice Mikael C. I. Karlsson, Sara Wernersson, Teresita Diaz de Ståhl, Susanne Gustavsson, and Birgitta Heyman PMCID: PMC26768 Innate and acquired humoral immunities to influenza virus are mediated by distinct arms of the immune system Nicole Baumgarth, Ometa C. Herman, Gina C. Jager, Lorena Brown, Leonard A. Herzenberg, and Leonore A. Herzenberg PMCID: PMC26769 Gene expression, synthesis, and secretion of interleukin 18 and interleukin 1β are differentially regulated in human blood mononuclear cells and mouse spleen cells Adrian J. Puren, Giamila Fantuzzi, and Charles A. Dinarello PMCID: PMC26770 Predominant VH genes expressed in innate antibodies are associated with distinctive antigen-binding sites Katherine J. Seidl, Jennifer A. Wilshire, John D. MacKenzie, Aaron B. Kantor, Leonard A. Herzenberg, and Leonore A. Herzenberg PMCID: PMC26771 Systemic administration of interleukin 2 enhances the therapeutic efficacy of dendritic cell-based tumor vaccines K. Shimizu, R. C. Fields, M. Giedlin, and J. J. Mulé PMCID: PMC26772 Dopamine β-hydroxylase deficiency impairs cellular immunity Robert C. Alaniz, Steven A. Thomas, Mercedes Perez-Melgosa, Kai Mueller, Andrew G. Farr, Richard D. Palmiter, and Christopher B. Wilson PMCID: PMC26773 Crossreactive recognition of viral, self, and bacterial peptide ligands by human class I-restricted cytotoxic T lymphocyte clonotypes: Implications for molecular mimicry in autoimmune disease Ihor S. Misko, Simone M. Cross, Rajiv Khanna, Suzanne L. Elliott, Christopher Schmidt, Stephanie J. Pye, and Sharon L. Silins PMCID: PMC26774 Activation of target-tissue immune-recognition molecules by double-stranded polynucleotides Koichi Suzuki, Atsumi Mori, Ken J. Ishii, Jun Saito, Dinah S. Singer, Dennis M. Klinman, Philip R. Krause, and Leonard D. Kohn PMCID: PMC26775 Medical Sciences In vivo analysis of the 3′ untranslated region of the hepatitis C virus after in vitro mutagenesis of an infectious cDNA clone Masayuki Yanagi, Marisa St. Claire, Suzanne U. Emerson, Robert H. Purcell, and Jens Bukh PMCID: PMC26776 Neonatal gene transfer leads to widespread correction of pathology in a murine model of lysosomal storage disease Thomas M. Daly, Carole Vogler, Beth Levy, Mark E. Haskins, and Mark S. Sands PMCID: PMC26777 Poly(ADP-ribose) polymerase gene disruption conferred mice resistant to streptozotocin-induced diabetes Mitsuko Masutani, Hiroshi Suzuki, Nobuo Kamada, Miho Watanabe, Otoya Ueda, Tadashige Nozaki, Kou-ichi Jishage, Takeshi Watanabe, Tetsuro Sugimoto, Hitoshi Nakagama, Takahiro Ochiya, and Takashi Sugimura PMCID: PMC26778 Mutations in the nebulin gene associated with autosomal recessive nemaline myopathy Katarina Pelin, Pirta Hilpelä, Kati Donner, Caroline Sewry, Patrick A. Akkari, Stephen D. Wilton, Duangrurdee Wattanasirichaigoon, Marie-Louise Bang, Thomas Centner, Folker Hanefeld, Sylvie Odent, Michel Fardeau, J. Andoni Urtizberea, Francesco Muntoni, Victor Dubowitz, Alan H. Beggs, Nigel G. Laing, Siegfried Labeit, Albert de la Chapelle, and Carina Wallgren-Pettersson PMCID: PMC26779 Blood-borne tissue factor: Another view of thrombosis Peter L. A. Giesen, Ursula Rauch, Bernd Bohrmann, Dorothee Kling, Merce Roqué, John T. Fallon, Juan J. Badimon, Jacques Himber, Markus A. Riederer, and Yale Nemerson PMCID: PMC26780 Mutated epithelial cadherin is associated with increased tumorigenicity and loss of adhesion and of responsiveness to the motogenic trefoil factor 2 in colon carcinoma cells J. A. Efstathiou, D. Liu, J. M. D. Wheeler, H. C. Kim, N. E. Beck, M. Ilyas, A. J. Karayiannakis, N. J. McC. Mortensen, W. Kmiot, R. J. Playford, M. Pignatelli, and W. F. Bodmer PMCID: PMC26781 Analysis of masked mutations in familial adenomatous polyposis Steven J. Laken, Nickolas Papadopoulos, Gloria M. Petersen, Stephen B. Gruber, Stanley R. Hamilton, Francis M. Giardiello, Jill D. Brensinger, Bert Vogelstein, and Kenneth W. Kinzler PMCID: PMC26782 Regulation of fatty acid homeostasis in cells: Novel role of leptin Roger H. Unger, Yan-Ting Zhou, and Lelio Orci PMCID: PMC26783 Imaging adenoviral-directed reporter gene expression in living animals with positron emission tomography Sanjiv S. Gambhir, Jorge R. Barrio, Michael E. Phelps, Meera Iyer, Mohammad Namavari, Nagichettiar Satyamurthy, Lily Wu, Leeta A. Green, Eileen Bauer, Duncan C. MacLaren, Khoi Nguyen, Arnold J. Berk, Simon R. Cherry, and Harvey R. Herschman PMCID: PMC26784 A different approach to treatment of phenylketonuria: Phenylalanine degradation with recombinant phenylalanine ammonia lyase Christineh N. Sarkissian, Zhongqi Shao, Françoise Blain, Rosalie Peevers, Hongsheng Su, Robert Heft, Thomas M. S. Chang, and Charles R. Scriver PMCID: PMC26785 Blockade of type β transforming growth factor signaling prevents liver fibrosis and dysfunction in the rat Zhe Qi, Nobuhiko Atsuchi, Akira Ooshima, Akira Takeshita, and Hikaru Ueno PMCID: PMC26786 Ex vivo evaluation of a Taylor-Couette flow, immobilized heparinase I device for clinical application Guillermo A. Ameer, Gilda Barabino, Ram Sasisekharan, William Harmon, Charles L. Cooney, and Robert Langer PMCID: PMC26787 Mutations in the organic cation/carnitine transporter OCTN2 in primary carnitine deficiency Yuhuan Wang, Jing Ye, Vadivel Ganapathy, and Nicola Longo PMCID: PMC26788 Gonadotropin-releasing hormone analogue conjugates with strong selective antitumor activity I. Pályi, B. Vincze, S. Lovas, I. Mező, J. Pató, A. Kálnay, G. Turi, D. Gaál, R. Mihalik, I. Péter, I. Teplán, and R. F. Murphy PMCID: PMC26789 Interferon γ expressed by a recombinant respiratory syncytial virus attenuates virus replication in mice without compromising immunogenicity Alexander Bukreyev, Stephen S. Whitehead, Natalya Bukreyeva, Brian R. Murphy, and Peter L. Collins PMCID: PMC26790 Induction of autoantibodies to mouse CCR5 with recombinant papillomavirus particles Bryce Chackerian, Douglas R. Lowy, and John T. Schiller PMCID: PMC26791 Streptavidin facilitates internalization and pulmonary targeting of an anti-endothelial cell antibody (platelet-endothelial cell adhesion molecule 1): A strategy for vascular immunotargeting of drugs Vladimir R. Muzykantov, Melpo Christofidou-Solomidou, Irina Balyasnikova, David W. Harshaw, Linda Schultz, Aron B. Fisher, and Steven M. Albelda PMCID: PMC26792 Inhibition of advanced glycation endproduct formation by acetaldehyde: Role in the cardioprotective effect of ethanol Yousef Al-Abed, Tomoko Mitsuhashi, Hongwei Li, John A. Lawson, Garret A. FitzGerald, Hank Founds, Thomas Donnelly, Anthony Cerami, Peter Ulrich, and Richard Bucala PMCID: PMC26793 Reversing adipocyte differentiation: Implications for treatment of obesity Yan-Ting Zhou, Zhuo-Wei Wang, Moritake Higa, Christopher B. Newgard, and Roger H. Unger PMCID: PMC26794 Microbiology The Salmonella invasin SipB induces macrophage apoptosis by binding to caspase-1 David Hersh, Denise M. Monack, Mark R. Smith, Nafisa Ghori, Stanley Falkow, and Arturo Zychlinsky PMCID: PMC26795 Continuous axenic cultivation of Pneumocystis carinii Salim Merali, Ute Frevert, Jonathan H. Williams, Kevin Chin, Richard Bryan, and Allen B. Clarkson, Jr. PMCID: PMC26796 Pseudomonas aeruginosa killing of Caenorhabditis elegans used to identify P. aeruginosa virulence factors Man-Wah Tan, Laurence G. Rahme, Jeffrey A. Sternberg, Ronald G. Tompkins, and Frederick M. Ausubel PMCID: PMC26797 Neurobiology Preferential Zn2+ influx through Ca2+-permeable AMPA/kainate channels triggers prolonged mitochondrial superoxide production Stefano L. Sensi, Hong Z. Yin, Sean G. Carriedo, Shyam S. Rao, and John H. Weiss PMCID: PMC26798 A binding site for homeodomain and Pax proteins is necessary for L1 cell adhesion molecule gene expression by Pax-6 and bone morphogenetic proteins Robyn Meech, Pekka Kallunki, Gerald M. Edelman, and Frederick S. Jones PMCID: PMC26799 The biological clock of very premature primate infants is responsive to light Haiping Hao and Scott A. Rivkees PMCID: PMC26800 Retinotopic mapping of lateral geniculate nucleus in humans using functional magnetic resonance imaging Wei Chen, Xiao-Hong Zhu, Keith R. Thulborn, and Kamil Ugurbil PMCID: PMC26801 Ca2+-induced inhibition of the cardiac Ca2+ channel depends on calmodulin Ning Qin, Riccardo Olcese, Michael Bransby, Tony Lin, and Lutz Birnbaumer PMCID: PMC26802 Ectopic bone morphogenetic proteins 5 and 4 in the chicken forebrain lead to cyclopia and holoprosencephaly Jeffrey A. Golden, Ana Bracilovic, Kathryn A. McFadden, Jacqueline S. Beesley, John L.R. Rubenstein, and Judith B. Grinspan PMCID: PMC26803 Bilirubin, formed by activation of heme oxygenase-2, protects neurons against oxidative stress injury Sylvain Doré, Masaaki Takahashi, Christopher D. Ferris, Lynda D. Hester, Daniel Guastella, and Solomon H. Snyder PMCID: PMC26804 Overexpression of a Shaker-type potassium channel in mammalian central nervous system dysregulates native potassium channel gene expression M. L. Sutherland, S. H. Williams, R. Abedi, P. A. Overbeek, P. J. Pfaffinger, and J. L. Noebels PMCID: PMC26805 Dopamine receptor subtypes modulate olfactory bulb γ-aminobutyric acid type A receptors Ina Brünig, Michael Sommer, Hanns Hatt, and Joachim Bormann PMCID: PMC26806 Growth factor-mediated Fyn signaling regulates α-amino-3- hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor expression in rodent neocortical neurons Mako Narisawa-Saito, Alcino J. Silva, Tsuyoshi Yamaguchi, Takashi Hayashi, Tadashi Yamamoto, and Hiroyuki Nawa PMCID: PMC26807 Molecular identification of human G-substrate, a possible downstream component of the cGMP-dependent protein kinase cascade in cerebellar Purkinje cells Shogo Endo, Masako Suzuki, Mariko Sumi, Angus C. Nairn, Ryoji Morita, Kazuhiro Yamakawa, Paul Greengard, and Masao Ito PMCID: PMC26808 Autoinhibition of serotonin cells: An intrinsic regulatory mechanism sensitive to the pattern of usage of the cells Ralf Heinrich, Stuart I. Cromarty, Michael Hörner, Donald H. Edwards, and Edward A. Kravitz PMCID: PMC26809 A neomorphic syntaxin mutation blocks volatile-anesthetic action in Caenorhabditis elegans Bruno van Swinderen, Owais Saifee, Laynie Shebester, Russell Roberson, Michael L. Nonet, and C. Michael Crowder PMCID: PMC26810 Blockade of N-methyl-d-aspartate receptor activation suppresses learning-induced synaptic elimination Jörg Bock and Katharina Braun PMCID: PMC26811 Cloning, expression, and genetic mapping of Sema W, a member of the semaphorin family Jeffrey A. Encinas, Kaoru Kikuchi, Alain Chedotal, Fernando de Castro, Corey S. Goodman, and Toru Kimura PMCID: PMC26812 Reverse genetic analysis of Caenorhabditis elegans presenilins reveals redundant but unequal roles for sel-12 and hop-1 in Notch-pathway signaling Bethany Westlund, Dianne Parry, Ralph Clover, Michael Basson, and Carl D. Johnson PMCID: PMC26813 Pharmacology Gβ5 prevents the RGS7-Gαo interaction through binding to a distinct Gγ-like domain found in RGS7 and other RGS proteins Konstantin Levay, Jorge L. Cabrera, Daulet K. Satpaev, and Vladlen Z. Slepak PMCID: PMC26814 N-Methyl-d-aspartate antagonists and apoptotic cell death triggered by head trauma in developing rat brain D. Pohl, P. Bittigau, M. J. Ishimaru, D. Stadthaus, C. Hübner, J. W. Olney, L. Turski, and C. Ikonomidou PMCID: PMC26815 Physiology Epithelial sodium channel regulated by aldosterone-induced protein sgk Sei-yu Chen, Aditi Bhargava, Luca Mastroberardino, Onno C. Meijer, Jian Wang, Patricia Buse, Gary L. Firestone, Francois Verrey, and David Pearce PMCID: PMC26816 Hormonal prevention of breast cancer: Mimicking the protective effect of pregnancy Raphael C. Guzman, Jason Yang, Lakshmanaswamy Rajkumar, Gudmundur Thordarson, Xiaoyan Chen, and Satyabrata Nandi PMCID: PMC26817 Two gonadotropin-releasing hormone receptor subtypes with distinct ligand selectivity and differential distribution in brain and pituitary in the goldfish (Carassius auratus) Nicola Illing, Brigitte E. Troskie, Carol S. Nahorniak, Janet P. Hapgood, Richard E. Peter, and Robert P. Millar PMCID: PMC26818 Correlation of regional cerebral blood flow and change of plasma sodium concentration during genesis and satiation of thirst Derek Denton, Robert Shade, Frank Zamarippa, Gary Egan, John Blair-West, Michael McKinley, and Peter Fox PMCID: PMC26819 Tonicity-responsive enhancer binding protein, a Rel-like protein that stimulates transcription in response to hypertonicity Hiroshi Miyakawa, Seung Kyoon Woo, Stephen C. Dahl, Joseph S. Handler, and H. Moo Kwon PMCID: PMC26820 Modulation of the baboon (Papio anubis) uterine endometrium by chorionic gonadotrophin during the period of uterine receptivity Asgerally T. Fazleabas, Kathleen M. Donnelly, Sudha Srinivasan, Jeffrey D. Fortman, and Josephine B. Miller PMCID: PMC26821 Plant Biology Expression of alfalfa mosaic virus coat protein in tobacco mosaic virus (TMV) deficient in the production of its native coat protein supports long-distance movement of a chimeric TMV S. Spitsin, K. Steplewski, N. Fleysh, H. Belanger, T. Mikheeva, S. Shivprasad, W. Dawson, H. Koprowski, and V. Yusibov PMCID: PMC26822 Male gametic cell-specific gene expression in flowering plants Huiling Xu, Ines Swoboda, Prem L. Bhalla, and Mohan B. Singh PMCID: PMC26823 Social Sciences Anthropology Canine sexual dimorphism in Egyptian Eocene anthropoid primates: Catopithecus and Proteopithecus Elwyn L. Simons, J. Michael Plavcan, and John G. Fleagle PMCID: PMC26824 Prehistoric birds from New Ireland, Papua New Guinea: Extinctions on a large Melanesian island David W. Steadman, J. Peter White, and Jim Allen PMCID: PMC26825 Corrections Proc Natl Acad Sci U S A. 1999 March 2; 96(5): 2569. PMCID: PMC56035 Corrects: Mark Stamnes, et al. ADP-ribosylation factor and phosphatidic acid levels in Golgi membranes during budding of coatomer-coated vesicles. Proc Natl Acad Sci U S A. 1998 November 10; 95(23): 13676–13680. Proc Natl Acad Sci U S A. 1999 March 2; 96(5): 2569. PMCID: PMC56036 Corrects: S W Young, et al. Gadolinium(III) texaphyrin: a tumor selective radiation sensitizer that is detectable by MRI. Proc Natl Acad Sci U S A. 1996 June 25; 93(13): 6610–6615. Proc Natl Acad Sci U S A. 1999 March 2; 96(5): 2569. PMCID: PMC56037 Corrects: Pradeep K. Singh, et al. Production of β-defensins by human airway epithelia. Proc Natl Acad Sci U S A. 1998 December 8; 95(25): 14961–14966. Proc Natl Acad Sci U S A. 1999 March 2; 96(5): 2569. PMCID: PMC56038 Corrects: L. Austin Doyle, et al. A multidrug resistance transporter from human MCF-7 breast cancer cells. Proc Natl Acad Sci U S A. 1998 December 22; 95(26): 15665–15670. |
