| | This journal provides immediate access to some articles. Commentaries Equality for the sexes in human evolution? Early hominid sexual
dimorphism and implications for mating systems and social behavior Clark Spencer Larsen Proc Natl Acad Sci U S A. 2003 August 5; 100(16): 9103–9104. Published online 2003 July 28. doi: 10.1073/pnas.1633678100.PMCID: PMC170877 Perspectives on the counterion switch-induced photoactivation of the G
protein-coupled receptor rhodopsin Robert R. Birge and Barry E. Knox Proc Natl Acad Sci U S A. 2003 August 5; 100(16): 9105–9107. Published online 2003 July 28. doi: 10.1073/pnas.1733801100.PMCID: PMC170878 Nonsteroidal antiinflammatory drugs inhibiting prostanoid efflux: As easy
as ABC? Timothy D. Warner and Jane A. Mitchell Proc Natl Acad Sci U S A. 2003 August 5; 100(16): 9108–9110. Published online 2003 July 28. doi: 10.1073/pnas.1733826100.PMCID: PMC170879 Crystallizing ideas about Parkinson's disease Mark R. Cookson Proc Natl Acad Sci U S A. 2003 August 5; 100(16): 9111–9113. Published online 2003 July 28. doi: 10.1073/pnas.1633722100.PMCID: PMC170880 Economics and the evolution of life histories Alan R. Rogers Proc Natl Acad Sci U S A. 2003 August 5; 100(16): 9114–9115. Published online 2003 July 28. doi: 10.1073/pnas.1733942100.PMCID: PMC170881 Physical Sciences Chemistry A chemical approach for identifying O-GlcNAc-modified proteins
in cells David J. Vocadlo, Howard C. Hang, Eun-Ju Kim, John A. Hanover, and Carolyn R. Bertozzi Proc Natl Acad Sci U S A. 2003 August 5; 100(16): 9116–9121. Published online 2003 July 21. doi: 10.1073/pnas.1632821100.PMCID: PMC171382 Amplification of xenon NMR and MRI by remote detection Adam J. Moulé, Megan M. Spence, Song-I Han, Juliette A. Seeley, Kimberly L. Pierce, Sunil Saxena, and Alexander Pines Proc Natl Acad Sci U S A. 2003 August 5; 100(16): 9122–9127. Published online 2003 July 22. doi: 10.1073/pnas.1133497100.PMCID: PMC170882 Statistics Statistical significance for genomewide studies John D. Storey and Robert Tibshirani Proc Natl Acad Sci U S A. 2003 August 5; 100(16): 9440–9445. Published online 2003 July 25. doi: 10.1073/pnas.1530509100.PMCID: PMC170937 Biological Sciences Agricultural Sciences Gene RB cloned from Solanum bulbocastanum confers broad
spectrum resistance to potato late blight Junqi Song, James M. Bradeen, S. Kristine Naess, John A. Raasch, Susan M. Wielgus, Geraldine T. Haberlach, Jia Liu, Hanhui Kuang, Sandra Austin-Phillips, C. Robin Buell, John P. Helgeson, and Jiming Jiang Proc Natl Acad Sci U S A. 2003 August 5; 100(16): 9128–9133. Published online 2003 July 18. doi: 10.1073/pnas.1533501100.PMCID: PMC170883 Applied Biological Sciences Electrochemical interrogation of conformational changes as a reagentless
method for the sequence-specific detection of DNA Chunhai Fan, Kevin W. Plaxco, and Alan J. Heeger Proc Natl Acad Sci U S A. 2003 August 5; 100(16): 9134–9137. Published online 2003 July 16. doi: 10.1073/pnas.1633515100.PMCID: PMC170884 Conjugation to gold nanoparticles enhances polyethylenimine's transfer of
plasmid DNA into mammalian cells Mini Thomas and Alexander M. Klibanov Proc Natl Acad Sci U S A. 2003 August 5; 100(16): 9138–9143. Published online 2003 July 28. doi: 10.1073/pnas.1233634100.PMCID: PMC170885 Biochemistry Zinc and mechanical prowess in the jaws of Nereis, a marine
worm Helga C. Lichtenegger, Thomas Schöberl, Janne T. Ruokolainen, Julie O. Cross, Steve M. Heald, Henrik Birkedal, J. Herbert Waite, and Galen D. Stucky Proc Natl Acad Sci U S A. 2003 August 5; 100(16): 9144–9149. Published online 2003 July 28. doi: 10.1073/pnas.1632658100.PMCID: PMC170886 A cytokinetic function of Drosophila ORC6 protein resides in a
domain distinct from its replication activity Igor N. Chesnokov, Olga N. Chesnokova, and Michael Botchan Proc Natl Acad Sci U S A. 2003 August 5; 100(16): 9150–9155. Published online 2003 July 23. doi: 10.1073/pnas.1633580100.PMCID: PMC170887 From the Cover: Pheromone gland-specific fatty-acyl reductase of the silkmoth, Bombyx
mori Ken'ichi Moto, Toyoshi Yoshiga, Masanobu Yamamoto, Shunya Takahashi, Kazuhiro Okano, Tetsu Ando, Tadashi Nakata, and Shogo Matsumoto Proc Natl Acad Sci U S A. 2003 August 5; 100(16): 9156–9161. Published online 2003 July 18. doi: 10.1073/pnas.1531993100.PMCID: PMC170888 The lipoxygenase gene ALOXE3 implicated in skin differentiation
encodes a hydroperoxide isomerase Zheyong Yu, Claus Schneider, William E. Boeglin, Lawrence J. Marnett, and Alan R. Brash Proc Natl Acad Sci U S A. 2003 August 5; 100(16): 9162–9167. Published online 2003 July 24. doi: 10.1073/pnas.1633612100.PMCID: PMC170889 Coevolutionary patterns in plasminogen activation Inna P. Gladysheva, Ryan B. Turner, Irina Y. Sazonova, Lin Liu, and Guy L. Reed Proc Natl Acad Sci U S A. 2003 August 5; 100(16): 9168–9172. Published online 2003 July 23. doi: 10.1073/pnas.1631716100.PMCID: PMC170890 Biosynthesis of isoprenoids: Crystal structure of
4-diphosphocytidyl-2C-methyl-d-erythritol kinase Linda Miallau, Magnus S. Alphey, Lauris E. Kemp, Gordon A. Leonard, Sean M. McSweeney, Stefan Hecht, Adelbert Bacher, Wolfgang Eisenreich, Felix Rohdich, and William N. Hunter Proc Natl Acad Sci U S A. 2003 August 5; 100(16): 9173–9178. Published online 2003 July 23. doi: 10.1073/pnas.1533425100.PMCID: PMC170891 Molecular genetics and evolution of pheromone biosynthesis in
Lepidoptera Wendell L. Roelofs and Alejandro P. Rooney Proc Natl Acad Sci U S A. 2003 August 5; 100(16): 9179–9184. Published online 2003 July 22. doi: 10.1073/pnas.1233767100.PMCID: PMC170892 Polyserase-I, a human polyprotease with the ability to generate
independent serine protease domains from a single translation product Santiago Cal, Víctor Quesada, Cecilia Garabaya, and Carlos López-Otín Proc Natl Acad Sci U S A. 2003 August 5; 100(16): 9185–9190. Published online 2003 July 28. doi: 10.1073/pnas.1633392100.PMCID: PMC170893 Long-distance conformational changes in a protein engineered by modulated
sequence duplication Martin Sagermann, Leslie Gay, and Brian W. Matthews Proc Natl Acad Sci U S A. 2003 August 5; 100(16): 9191–9195. Published online 2003 July 17. doi: 10.1073/pnas.1633549100.PMCID: PMC170894 A biochemical rationale for the discrete behavior of nitroxyl and nitric
oxide in the cardiovascular system Katrina M. Miranda, Nazareno Paolocci, Tatsuo Katori, Douglas D. Thomas, Eleonora Ford, Michael D. Bartberger, Michael G. Espey, David A. Kass, Martin Feelisch, Jon M. Fukuto, and David A. Wink Proc Natl Acad Sci U S A. 2003 August 5; 100(16): 9196–9201. Published online 2003 July 15. doi: 10.1073/pnas.1430507100.PMCID: PMC170895 Differential binding of NAD+ and NADH allows the
transcriptional corepressor carboxyl-terminal binding protein to serve as a
metabolic sensor Clark C. Fjeld, William T. Birdsong, and Richard H. Goodman Proc Natl Acad Sci U S A. 2003 August 5; 100(16): 9202–9207. Published online 2003 July 18. doi: 10.1073/pnas.1633591100.PMCID: PMC170896 A constitutively activated mutant of human soluble guanylyl cyclase
(sGC): Implication for the mechanism of sGC activation Emil Martin, Iraida Sharina, Alexander Kots, and Ferid Murad Proc Natl Acad Sci U S A. 2003 August 5; 100(16): 9208–9213. Published online 2003 July 25. doi: 10.1073/pnas.1633590100.PMCID: PMC170897 Crystal structure of an RNA·DNA hybrid reveals intermolecular
intercalation: Dimer formation by base-pair swapping Gye Won Han, Mary L. Kopka, David Langs, Michael R. Sawaya, and Richard E. Dickerson Proc Natl Acad Sci U S A. 2003 August 5; 100(16): 9214–9219. Published online 2003 July 18. doi: 10.1073/pnas.1533326100.PMCID: PMC170898 Role of extracellular subdomains of p185c-neu and the
epidermal growth factor receptor in ligand-independent association and
transactivation Toru Kumagai, Makoto Katsumata, Akihiro Hasegawa, Keiji Furuuchi, Toshiki Funakoshi, Ichiro Kawase, and Mark I. Greene Proc Natl Acad Sci U S A. 2003 August 5; 100(16): 9220–9225. Published online 2003 July 16. doi: 10.1073/pnas.1633546100.PMCID: PMC170899 Inhibition of heregulin signaling by an aptamer that preferentially binds
to the oligomeric form of human epidermal growth factor receptor-3 Chi-hong B. Chen, George A. Chernis, Van Q. Hoang, and Ralf Landgraf Proc Natl Acad Sci U S A. 2003 August 5; 100(16): 9226–9231. Published online 2003 July 21. doi: 10.1073/pnas.1332660100.PMCID: PMC170900 Toward a protein profile of Escherichia coli: Comparison to its
transcription profile Rebecca W. Corbin, Oleg Paliy, Feng Yang, Jeffrey Shabanowitz, Mark Platt, Charles E. Lyons, Jr., Karen Root, Jon McAuliffe, Michael I. Jordan, Sydney Kustu, Eric Soupene, and Donald F. Hunt Proc Natl Acad Sci U S A. 2003 August 5; 100(16): 9232–9237. Published online 2003 July 23. doi: 10.1073/pnas.1533294100.PMCID: PMC170901 Structure of the TDP-epi-vancosaminyltransferase GtfA from the
chloroeremomycin biosynthetic pathway Anne M. Mulichak, Heather C. Losey, Wei Lu, Zdzislaw Wawrzak, Christopher T. Walsh, and R. Michael Garavito Proc Natl Acad Sci U S A. 2003 August 5; 100(16): 9238–9243. Published online 2003 July 21. doi: 10.1073/pnas.1233577100.PMCID: PMC170902 The human multidrug resistance protein MRP4 functions as a prostaglandin
efflux transporter and is inhibited by nonsteroidal antiinflammatory
drugs Glen Reid, Peter Wielinga, Noam Zelcer, Ingrid van der Heijden, Annemieke Kuil, Marcel de Haas, Jan Wijnholds, and Piet Borst Proc Natl Acad Sci U S A. 2003 August 5; 100(16): 9244–9249. Published online 2003 June 30. doi: 10.1073/pnas.1033060100.PMCID: PMC170903 Escherichia coli single-stranded DNA-binding protein mediates template
recycling during transcription by bacteriophage N4 virion RNA polymerase Elena K. Davydova and Lucia B. Rothman-Denes Proc Natl Acad Sci U S A. 2003 August 5; 100(16): 9250–9255. Published online 2003 July 22. doi: 10.1073/pnas.1133325100.PMCID: PMC170904 Biophysics From the Cover: The 1.1-Å resolution crystal structure of DJ-1, the protein mutated
in autosomal recessive early onset Parkinson's disease Mark A. Wilson, Jennifer L. Collins, Yaacov Hod, Dagmar Ringe, and Gregory A. Petsko Proc Natl Acad Sci U S A. 2003 August 5; 100(16): 9256–9261. Published online 2003 July 10. doi: 10.1073/pnas.1133288100.PMCID: PMC170905 From the Cover: Retinal counterion switch in the photoactivation of the G protein-coupled
receptor rhodopsin Elsa C. Y. Yan, Manija A. Kazmi, Ziad Ganim, Jian-Min Hou, Douhai Pan, Belinda S. W. Chang, Thomas P. Sakmar, and Richard A. Mathies Proc Natl Acad Sci U S A. 2003 August 5; 100(16): 9262–9267. Published online 2003 June 30. doi: 10.1073/pnas.1531970100.PMCID: PMC170906 Crystal structure of NF-κB (p50)2 complexed to a
high-affinity RNA aptamer De-Bin Huang, Don Vu, Laura A. Cassiday, Jeff M. Zimmerman, L. James Maher, III, and Gourisankar Ghosh Proc Natl Acad Sci U S A. 2003 August 5; 100(16): 9268–9273. Published online 2003 July 28. doi: 10.1073/pnas.1632011100.PMCID: PMC170907 Cell organization in soft media due to active mechanosensing I. B. Bischofs and U. S. Schwarz Proc Natl Acad Sci U S A. 2003 August 5; 100(16): 9274–9279. Published online 2003 July 25. doi: 10.1073/pnas.1233544100.PMCID: PMC170908 Visualizing infection of individual influenza viruses Melike Lakadamyali, Michael J. Rust, Hazen P. Babcock, and Xiaowei Zhuang Proc Natl Acad Sci U S A. 2003 August 5; 100(16): 9280–9285. Published online 2003 July 25. doi: 10.1073/pnas.0832269100.PMCID: PMC170909 Importance of low-oligomeric-weight species for prion propagation in the
yeast prion system Sup35/Hsp104 Saravanakumar Narayanan, Benjamin Bösl, Stefan Walter, and Bernd Reif Proc Natl Acad Sci U S A. 2003 August 5; 100(16): 9286–9291. Published online 2003 July 22. doi: 10.1073/pnas.1233535100.PMCID: PMC170910 Osmotic pressure inhibition of DNA ejection from phage Alex Evilevitch, Laurence Lavelle, Charles M. Knobler, Eric Raspaud, and William M. Gelbart Proc Natl Acad Sci U S A. 2003 August 5; 100(16): 9292–9295. Published online 2003 July 24. doi: 10.1073/pnas.1233721100.PMCID: PMC170911 Controlling the size of nanoscale toroidal DNA condensates with static
curvature and ionic strength Christine C. Conwell, Igor D. Vilfan, and Nicholas V. Hud Proc Natl Acad Sci U S A. 2003 August 5; 100(16): 9296–9301. Published online 2003 July 18. doi: 10.1073/pnas.1533135100.PMCID: PMC170912 Single-molecule transition-state analysis of RNA folding Gregory Bokinsky, David Rueda, Vinod K. Misra, Maria M. Rhodes, Andrew Gordus, Hazen P. Babcock, Nils G. Walter, and Xiaowei Zhuang Proc Natl Acad Sci U S A. 2003 August 5; 100(16): 9302–9307. Published online 2003 July 17. doi: 10.1073/pnas.1133280100.PMCID: PMC170913 A four-way junction accelerates hairpin ribozyme folding via a discrete
intermediate Elliot Tan, Timothy J. Wilson, Michelle K. Nahas, Robert M. Clegg, David M. J. Lilley, and Taekjip Ha Proc Natl Acad Sci U S A. 2003 August 5; 100(16): 9308–9313. Published online 2003 July 25. doi: 10.1073/pnas.1233536100.PMCID: PMC170914 The ATP-waiting conformation of rotating F1-ATPase revealed by
single-pair fluorescence resonance energy transfer Ryohei Yasuda, Tomoko Masaike, Kengo Adachi, Hiroyuki Noji, Hiroyasu Itoh, and Kazuhiko Kinosita, Jr. Proc Natl Acad Sci U S A. 2003 August 5; 100(16): 9314–9318. Published online 2003 July 22. doi: 10.1073/pnas.1637860100.PMCID: PMC170915 Dynamic reorganization of the functionally active ribosome explored by
normal mode analysis and cryo-electron microscopy Florence Tama, Mikel Valle, Joachim Frank, and Charles L. Brooks, III Proc Natl Acad Sci U S A. 2003 August 5; 100(16): 9319–9323. Published online 2003 July 23. doi: 10.1073/pnas.1632476100.PMCID: PMC170916 Cell Biology Visualizing infection of individual influenza viruses Melike Lakadamyali, Michael J. Rust, Hazen P. Babcock, and Xiaowei Zhuang Proc Natl Acad Sci U S A. 2003 August 5; 100(16): 9280–9285. Published online 2003 July 25. doi: 10.1073/pnas.0832269100.PMCID: PMC170909 Bad-deficient mice develop diffuse large B cell lymphoma Ann M. Ranger, Jiping Zha, Hisashi Harada, Sandeep Robert Datta, Nika N. Danial, Andrew P. Gilmore, Jeffery L. Kutok, Michelle M. Le Beau, Michael E. Greenberg, and Stanley J. Korsmeyer Proc Natl Acad Sci U S A. 2003 August 5; 100(16): 9324–9329. Published online 2003 July 22. doi: 10.1073/pnas.1533446100.PMCID: PMC170917 Profiling receptor tyrosine kinase activation by using Ab
microarrays Ulrik B. Nielsen, Mike H. Cardone, Anthony J. Sinskey, Gavin MacBeath, and Peter K. Sorger Proc Natl Acad Sci U S A. 2003 August 5; 100(16): 9330–9335. Published online 2003 July 22. doi: 10.1073/pnas.1633513100.PMCID: PMC170918 Skeletal muscle engraftment potential of adult mouse skin side population
cells Federica Montanaro, Kalliopi Liadaki, Jay Volinski, Alan Flint, and Louis M. Kunkel Proc Natl Acad Sci U S A. 2003 August 5; 100(16): 9336–9341. Published online 2003 July 28. doi: 10.1073/pnas.1133179100.PMCID: PMC170919 The cell death regulator GRIM-19 is an inhibitor of signal transducer and
activator of transcription 3 Jun Zhang, Jinbo Yang, Sanjit K. Roy, Silvia Tininini, Jiadi Hu, Jacqueline F. Bromberg, Valeria Poli, George R. Stark, and Dhananjaya V. Kalvakolanu Proc Natl Acad Sci U S A. 2003 August 5; 100(16): 9342–9347. Published online 2003 July 16. doi: 10.1073/pnas.1633516100.PMCID: PMC170920 Regulation of gonadotropin gene expression by Müllerian inhibiting
substance Grégoy Y. Bédécarrats, Francis H. O'Neill, Errol R. Norwitz, Ursula B. Kaiser, and Jose Teixeira Proc Natl Acad Sci U S A. 2003 August 5; 100(16): 9348–9353. Published online 2003 July 23. doi: 10.1073/pnas.1633592100.PMCID: PMC170921 The p53-dependent effects of macrophage migration inhibitory factor
revealed by gene targeting G. Fingerle-Rowson, O. Petrenko, C. N. Metz, T. G. Forsthuber, R. Mitchell, R. Huss, U. Moll, W. Müller, and R. Bucala Proc Natl Acad Sci U S A. 2003 August 5; 100(16): 9354–9359. Published online 2003 July 23. doi: 10.1073/pnas.1533295100.PMCID: PMC170922 Developmental Biology Sox9 is required for determination of the chondrogenic cell lineage in
the cranial neural crest Yuko Mori-Akiyama, Haruhiko Akiyama, David H. Rowitch, and Benoit de Crombrugghe Proc Natl Acad Sci U S A. 2003 August 5; 100(16): 9360–9365. Published online 2003 July 23. doi: 10.1073/pnas.1631288100.PMCID: PMC170923 The serum response factor coactivator myocardin is required for vascular
smooth muscle development Shijie Li, Da-Zhi Wang, Zhigao Wang, James A. Richardson, and Eric N. Olson Proc Natl Acad Sci U S A. 2003 August 5; 100(16): 9366–9370. Published online 2003 July 16. doi: 10.1073/pnas.1233635100.PMCID: PMC170924 Transcriptional regulatory cascades in development: Initial rates, not
steady state, determine network kinetics Hamid Bolouri and Eric H. Davidson Proc Natl Acad Sci U S A. 2003 August 5; 100(16): 9371–9376. Published online 2003 July 25. doi: 10.1073/pnas.1533293100.PMCID: PMC170925 Ecology Tufted puffin reproduction reveals ocean climate variability Carina Gjerdrum, Anne M. J. Vallée, Colleen Cassady St. Clair, Douglas F. Bertram, John L. Ryder, and Gwylim S. Blackburn Proc Natl Acad Sci U S A. 2003 August 5; 100(16): 9377–9382. Published online 2003 July 18. doi: 10.1073/pnas.1133383100.PMCID: PMC170926 The nested assembly of plant–animal mutualistic networks Jordi Bascompte, Pedro Jordano, Carlos J. Melián, and Jens M. Olesen Proc Natl Acad Sci U S A. 2003 August 5; 100(16): 9383–9387. Published online 2003 July 24. doi: 10.1073/pnas.1633576100.PMCID: PMC170927 Evolution The genome sequence of Blochmannia floridanus: Comparative
analysis of reduced genomes Rosario Gil, Francisco J. Silva, Evelyn Zientz, François Delmotte, Fernando González-Candelas, Amparo Latorre, Carolina Rausell, Judith Kamerbeek, Jürgen Gadau, Bert Hölldobler, Roeland C. H. J. van Ham, Roy Gross, and Andrés Moya Proc Natl Acad Sci U S A. 2003 August 5; 100(16): 9388–9393. Published online 2003 July 28. doi: 10.1073/pnas.1533499100.PMCID: PMC170928 Worker caste polymorphism has a genetic basis in Acromyrmex
leaf-cutting ants William O. H. Hughes, Seirian Sumner, Steven Van Borm, and Jacobus J. Boomsma Proc Natl Acad Sci U S A. 2003 August 5; 100(16): 9394–9397. Published online 2003 July 23. doi: 10.1073/pnas.1633701100.PMCID: PMC170929 Microarray analysis of evolution of RNA viruses: Evidence of circulation
of virulent highly divergent vaccine-derived polioviruses Elena Cherkasova, Majid Laassri, Vladimir Chizhikov, Ekaterina Korotkova, Eugenia Dragunsky, Vadim I. Agol, and Konstantin Chumakov Proc Natl Acad Sci U S A. 2003 August 5; 100(16): 9398–9403. Published online 2003 July 23. doi: 10.1073/pnas.1633511100.PMCID: PMC170930 From the Cover: Sexual dimorphism in Australopithecus afarensis was similar to
that of modern humans Philip L. Reno, Richard S. Meindl, Melanie A. McCollum, and C. Owen Lovejoy Proc Natl Acad Sci U S A. 2003 August 5; 100(16): 9404–9409. Published online 2003 July 23. doi: 10.1073/pnas.1133180100.PMCID: PMC170931 Genetics An interacting network of T-box genes directs gene expression and fate in
the zebrafish mesoderm Lisa M. Goering, Kazuyuki Hoshijima, Barbara Hug, Brent Bisgrove, Andreas Kispert, and David Jonah Grunwald Proc Natl Acad Sci U S A. 2003 August 5; 100(16): 9410–9415. Published online 2003 July 25. doi: 10.1073/pnas.1633548100.PMCID: PMC170932 Suppressive function of androgen receptor in bone resorption Hirotaka Kawano, Takashi Sato, Takashi Yamada, Takahiro Matsumoto, Keisuke Sekine, Tomoyuki Watanabe, Takashi Nakamura, Toru Fukuda, Kimihiro Yoshimura, Tatsuya Yoshizawa, Ken-ichi Aihara, Yoko Yamamoto, Yuko Nakamichi, Daniel Metzger, Pierre Chambon, Kozo Nakamura, Hiroshi Kawaguchi, and Shigeaki Kato Proc Natl Acad Sci U S A. 2003 August 5; 100(16): 9416–9421. Published online 2003 July 18. doi: 10.1073/pnas.1533500100.PMCID: PMC170933 Cloning and characterization of the Drosophila U7 small nuclear
RNA Zbigniew Dominski, Xiao-cui Yang, Matthew Purdy, and William F. Marzluff Proc Natl Acad Sci U S A. 2003 August 5; 100(16): 9422–9427. Published online 2003 July 18. doi: 10.1073/pnas.1533509100.PMCID: PMC170934 Protein–DNA interaction mapping using genomic tiling path
microarrays in Drosophila Ling V. Sun, Liang Chen, Frauke Greil, Nicolas Negre, Tong-Ruei Li, Giacomo Cavalli, Hongyu Zhao, Bas van Steensel, and Kevin P. White Proc Natl Acad Sci U S A. 2003 August 5; 100(16): 9428–9433. Published online 2003 July 22. doi: 10.1073/pnas.1533393100.PMCID: PMC170935 A new class of mutations reveals a novel function for the original
phosphatidylinositol 3-kinase binding site Y. Kate Hong, Aki Mikami, Brian Schaffhausen, Toni Jun, and Thomas M. Roberts Proc Natl Acad Sci U S A. 2003 August 5; 100(16): 9434–9439. Published online 2003 July 24. doi: 10.1073/pnas.1432964100.PMCID: PMC170936 Statistical significance for genomewide studies John D. Storey and Robert Tibshirani Proc Natl Acad Sci U S A. 2003 August 5; 100(16): 9440–9445. Published online 2003 July 25. doi: 10.1073/pnas.1530509100.PMCID: PMC170937 Immunology Structural insights into the antigenicity of myelin oligodendrocyte
glycoprotein Constanze Breithaupt, Anna Schubart, Hilke Zander, Arne Skerra, Robert Huber, Christopher Linington, and Uwe Jacob Proc Natl Acad Sci U S A. 2003 August 5; 100(16): 9446–9451. Published online 2003 July 21. doi: 10.1073/pnas.1133443100.PMCID: PMC170938 Stimulation of T cell autoreactivity by anomalous expression of NKG2D and
its MIC ligands in rheumatoid arthritis Veronika Groh, Anja Brühl, Hani El-Gabalawy, J. Lee Nelson, and Thomas Spies Proc Natl Acad Sci U S A. 2003 August 5; 100(16): 9452–9457. Published online 2003 July 23. doi: 10.1073/pnas.1632807100.PMCID: PMC170939 Shared modes of protection against poxvirus infection by attenuated and
conventional smallpox vaccine viruses Igor M. Belyakov, Patricia Earl, Amiran Dzutsev, Vladimir A. Kuznetsov, Michael Lemon, Linda S. Wyatt, James T. Snyder, Jeffrey D. Ahlers, Genoveffa Franchini, Bernard Moss, and Jay A. Berzofsky Proc Natl Acad Sci U S A. 2003 August 5; 100(16): 9458–9463. Published online 2003 July 17. doi: 10.1073/pnas.1233578100.PMCID: PMC170940 α-Galactosylceramide (KRN7000) suppression of chemical- and
oncogene-dependent carcinogenesis Yoshihiro Hayakawa, Stefania Rovero, Guido Forni, and Mark J. Smyth Proc Natl Acad Sci U S A. 2003 August 5; 100(16): 9464–9469. Published online 2003 July 16. doi: 10.1073/pnas.1630663100.PMCID: PMC170941 A Ras activation pathway dependent on Syk phosphorylation of protein
kinase C Yuko Kawakami, Jiro Kitaura, Libo Yao, Robert W. McHenry, Yu Kawakami, Alexandra C. Newton, Shin Kang, Roberta M. Kato, Michael Leitges, David J. Rawlings, and Toshiaki Kawakami Proc Natl Acad Sci U S A. 2003 August 5; 100(16): 9470–9475. Published online 2003 July 24. doi: 10.1073/pnas.1633695100.PMCID: PMC170942 Medical Sciences Insig-1 “brakes” lipogenesis in adipocytes and inhibits
differentiation of preadipocytes Jinping Li, Kiyosumi Takaishi, William Cook, Sara Kay McCorkle, and Roger H. Unger Proc Natl Acad Sci U S A. 2003 August 5; 100(16): 9476–9481. Published online 2003 July 17. doi: 10.1073/pnas.1133426100.PMCID: PMC170943 Activated integrin αvβ3 cooperates with metalloproteinase
MMP-9 in regulating migration of metastatic breast cancer cells Melanie Rolli, Emilia Fransvea, Jan Pilch, Alan Saven, and Brunhilde Felding-Habermann Proc Natl Acad Sci U S A. 2003 August 5; 100(16): 9482–9487. Published online 2003 July 21. doi: 10.1073/pnas.1633689100.PMCID: PMC170944 Dehydroepiandrosterone (DHEA) prevents and reverses chronic hypoxic
pulmonary hypertension Sébastien Bonnet, Eric Dumas-de-La-Roque, Hugues Bégueret, Roger Marthan, Michael Fayon, Pierre Dos Santos, Jean-Pierre Savineau, and Etienne-Emile Baulieu Proc Natl Acad Sci U S A. 2003 August 5; 100(16): 9488–9493. Published online 2003 July 23. doi: 10.1073/pnas.1633724100.PMCID: PMC170945 Angiopoietin-related growth factor (AGF) promotes epidermal
proliferation, remodeling, and regeneration Yuichi Oike, Kunio Yasunaga, Yasuhiro Ito, Shun-ichiro Matsumoto, Hiromitsu Maekawa, Tohru Morisada, Fumio Arai, Naomi Nakagata, Motohiro Takeya, Yasuhiko Masuho, and Toshio Suda Proc Natl Acad Sci U S A. 2003 August 5; 100(16): 9494–9499. Published online 2003 July 18. doi: 10.1073/pnas.1531901100.PMCID: PMC170946 Mechanisms of HFE-induced regulation of iron homeostasis: Insights from
the W81A HFE mutation An-Sheng Zhang, Paige S. Davies, Hanqian L. Carlson, and Caroline A. Enns Proc Natl Acad Sci U S A. 2003 August 5; 100(16): 9500–9505. Published online 2003 July 21. doi: 10.1073/pnas.1233675100.PMCID: PMC170947 An activated receptor tyrosine kinase, TEL/PDGFβR, cooperates with
AML1/ETO to induce acute myeloid leukemia in mice Jay L. Grisolano, Julie O'Neal, Jennifer Cain, and Michael H. Tomasson Proc Natl Acad Sci U S A. 2003 August 5; 100(16): 9506–9511. Published online 2003 July 24. doi: 10.1073/pnas.1531730100.PMCID: PMC170948 Ligand-dependent and -independent effects of splice variant 1 of growth
hormone-releasing hormone receptor Hippokratis Kiaris, Ioulia Chatzistamou, Andrew V. Schally, Gabor Halmos, Jozsef L. Varga, Helen Koutselini, and Anastasios Kalofoutis Proc Natl Acad Sci U S A. 2003 August 5; 100(16): 9512–9517. Published online 2003 July 16. doi: 10.1073/pnas.1533185100.PMCID: PMC170949 A decline in the levels of progesterone receptor coactivators in the
pregnant uterus at term may antagonize progesterone receptor function and
contribute to the initiation of parturition Jennifer C. Condon, Pancharatnam Jeyasuria, Julie M. Faust, James W. Wilson, and Carole R. Mendelson Proc Natl Acad Sci U S A. 2003 August 5; 100(16): 9518–9523. Published online 2003 July 28. doi: 10.1073/pnas.1633616100.PMCID: PMC170950 Repression of c-Myc and inhibition of G1 exit in
cells conditionally overexpressing p300 that is not dependent on its
histone acetyltransferase activity Sudhakar Baluchamy, Hasan N. Rajabi, Rama Thimmapaya, Arunasalam Navaraj, and Bayar Thimmapaya Proc Natl Acad Sci U S A. 2003 August 5; 100(16): 9524–9529. Published online 2003 July 25. doi: 10.1073/pnas.1633700100.PMCID: PMC170951 Clusterin as a biomarker in murine and human intestinal neoplasia Xiaodi Chen, Richard B. Halberg, William M. Ehrhardt, Jose Torrealba, and William F. Dove Proc Natl Acad Sci U S A. 2003 August 5; 100(16): 9530–9535. Published online 2003 July 28. doi: 10.1073/pnas.1233633100.PMCID: PMC170952 Microbiology The role(s) of lipophosphoglycan (LPG) in the establishment of
Leishmania major infections in mammalian hosts Gerald F. Späth, L. A. Garraway, Salvatore J. Turco, and Stephen M. Beverley Proc Natl Acad Sci U S A. 2003 August 5; 100(16): 9536–9541. Published online 2003 July 17. doi: 10.1073/pnas.1530604100.PMCID: PMC170953 Identification of iron-activated and -repressed Fur-dependent genes by
transcriptome analysis of Neisseria meningitidis group B Renata Grifantini, Shite Sebastian, Elisabetta Frigimelica, Monia Draghi, Erika Bartolini, Alessandro Muzzi, Rino Rappuoli, Guido Grandi, and Caroline Attardo Genco Proc Natl Acad Sci U S A. 2003 August 5; 100(16): 9542–9547. Published online 2003 July 25. doi: 10.1073/pnas.1033001100.PMCID: PMC170954 Neuroscience Differential regulation of microtubule dynamics by three- and four-repeat
tau: Implications for the onset of neurodegenerative disease Dulal Panda, Jonathan C. Samuel, Michelle Massie, Stuart C. Feinstein, and Leslie Wilson Proc Natl Acad Sci U S A. 2003 August 5; 100(16): 9548–9553. Published online 2003 July 28. doi: 10.1073/pnas.1633508100.PMCID: PMC170955 Glutamate carboxypeptidase II inhibition protects motor neurons from
death in familial amyotrophic lateral sclerosis models Ghanashyam D. Ghadge, Barbara S. Slusher, Amos Bodner, Mauro Dal Canto, Krystyna Wozniak, Ajit G. Thomas, Camilo Rojas, Takashi Tsukamoto, Pavel Majer, Richard J. Miller, Anna Liza Monti, and Raymond P. Roos Proc Natl Acad Sci U S A. 2003 August 5; 100(16): 9554–9559. Published online 2003 July 22. doi: 10.1073/pnas.1530168100.PMCID: PMC170956 Activity of the Caenorhabditis elegans UNC-86 POU transcription
factor modulates olfactory sensitivity Ji Ying Sze and Gary Ruvkun Proc Natl Acad Sci U S A. 2003 August 5; 100(16): 9560–9565. Published online 2003 July 25. doi: 10.1073/pnas.1530752100.PMCID: PMC170957 Nitric oxide negatively regulates mammalian adult neurogenesis Michael A. Packer, Yuri Stasiv, Abdellatif Benraiss, Eva Chmielnicki, Alexander Grinberg, Heiner Westphal, Steven A. Goldman, and Grigori Enikolopov Proc Natl Acad Sci U S A. 2003 August 5; 100(16): 9566–9571. Published online 2003 July 28. doi: 10.1073/pnas.1633579100.PMCID: PMC170958 Neuronal depletion of calcium-dependent proteins in the dentate gyrus is
tightly linked to Alzheimer's disease-related cognitive deficits Jorge J. Palop, Brian Jones, Lisa Kekonius, Jeannie Chin, Gui-Qiu Yu, Jacob Raber, Eliezer Masliah, and Lennart Mucke Proc Natl Acad Sci U S A. 2003 August 5; 100(16): 9572–9577. Published online 2003 July 24. doi: 10.1073/pnas.1133381100.PMCID: PMC170959 Stimulation of NeuroD activity by huntingtin and huntingtin-associated
proteins HAP1 and MLK2 Edoardo Marcora, Katherine Gowan, and Jacqueline E. Lee Proc Natl Acad Sci U S A. 2003 August 5; 100(16): 9578–9583. Published online 2003 July 24. doi: 10.1073/pnas.1133382100.PMCID: PMC170960 Bimodal circadian secretion of melatonin from the pineal gland in a
living CBA mouse Daiichiro Nakahara, Masato Nakamura, Masayuki Iigo, and Hitoshi Okamura Proc Natl Acad Sci U S A. 2003 August 5; 100(16): 9584–9589. Published online 2003 July 21. doi: 10.1073/pnas.1631069100.PMCID: PMC170961 Cathepsin L in secretory vesicles functions as a prohormone-processing
enzyme for production of the enkephalin peptide neurotransmitter Sukkid Yasothornsrikul, Doron Greenbaum, Katalin F. Medzihradszky, Thomas Toneff, Richard Bundey, Ruthellen Miller, Birgit Schilling, Ivonne Petermann, Jessica Dehnert, Anna Logvinova, Paul Goldsmith, John M. Neveu, William S. Lane, Bradford Gibson, Thomas Reinheckel, Christoph Peters, Matthew Bogyo, and Vivian Hook Proc Natl Acad Sci U S A. 2003 August 5; 100(16): 9590–9595. Published online 2003 July 17. doi: 10.1073/pnas.1531542100.PMCID: PMC170962 Executive and social behaviors under nicotinic receptor regulation Sylvie Granon, Philippe Faure, and Jean-Pierre Changeux Proc Natl Acad Sci U S A. 2003 August 5; 100(16): 9596–9601. Published online 2003 July 22. doi: 10.1073/pnas.1533498100.PMCID: PMC170963 Two previously undescribed members of the mouse CPEB family of genes and
their inducible expression in the principal cell layers of the
hippocampus Martin Theis, Kausik Si, and Eric R. Kandel Proc Natl Acad Sci U S A. 2003 August 5; 100(16): 9602–9607. Published online 2003 July 18. doi: 10.1073/pnas.1133424100.PMCID: PMC170964 Pharmacology Prediction of clinical drug efficacy by classification of drug-induced
genomic expression profiles in vitro Erik C. Gunther, David J. Stone, Robert W. Gerwien, Patricia Bento, and Melvyn P. Heyes Proc Natl Acad Sci U S A. 2003 August 5; 100(16): 9608–9613. Published online 2003 July 17. doi: 10.1073/pnas.1632587100.PMCID: PMC170965 Estrogen receptor-α mediates the brain antiinflammatory activity of
estradiol Elisabetta Vegeto, Silvia Belcredito, Sabrina Etteri, Serena Ghisletti, Alessia Brusadelli, Clara Meda, Andrée Krust, Sonia Dupont, Paolo Ciana, Pierre Chambon, and Adriana Maggi Proc Natl Acad Sci U S A. 2003 August 5; 100(16): 9614–9619. Published online 2003 July 23. doi: 10.1073/pnas.1531957100.PMCID: PMC170966 Physiology A kinase-regulated mechanism controls CFTR channel gating by disrupting
bivalent PDZ domain interactions Viswanathan Raghuram, Hayley Hormuth, and J. Kevin Foskett Proc Natl Acad Sci U S A. 2003 August 5; 100(16): 9620–9625. Published online 2003 July 24. doi: 10.1073/pnas.1633250100.PMCID: PMC170967 Plant Biology AthPEX10, a nuclear gene essential for peroxisome and storage organelle
formation during Arabidopsis embryogenesis Uwe Schumann, Gerhard Wanner, Marten Veenhuis, Markus Schmid, and Christine Gietl Proc Natl Acad Sci U S A. 2003 August 5; 100(16): 9626–9631. Published online 2003 July 25. doi: 10.1073/pnas.1633697100.PMCID: PMC170968 Short interfering RNA-mediated interference of gene expression and viral
DNA accumulation in cultured plant cells Ramachandran Vanitharani, Padmanabhan Chellappan, and Claude M. Fauquet Proc Natl Acad Sci U S A. 2003 August 5; 100(16): 9632–9636. Published online 2003 July 28. doi: 10.1073/pnas.1733874100.PMCID: PMC170969 Social Sciences Social Sciences From the Cover: Rethinking the evolutionary theory of aging: Transfers, not births, shape
senescence in social species Ronald D. Lee Proc Natl Acad Sci U S A. 2003 August 5; 100(16): 9637–9642. Published online 2003 July 23. doi: 10.1073/pnas.1530303100.PMCID: PMC170970 |