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Volume 100(16);  August 5, 2003
Commentaries
Equality for the sexes in human evolution? Early hominid sexual dimorphism and implications for mating systems and social behavior
Clark Spencer Larsen
Proc Natl Acad Sci U S A. 2003 August 5; 100(16): 9103–9104. Published online 2003 July 28. doi: 10.1073/pnas.1633678100.
PMCID: PMC170877
Perspectives on the counterion switch-induced photoactivation of the G protein-coupled receptor rhodopsin
Robert R. Birge and Barry E. Knox
Proc Natl Acad Sci U S A. 2003 August 5; 100(16): 9105–9107. Published online 2003 July 28. doi: 10.1073/pnas.1733801100.
PMCID: PMC170878
Nonsteroidal antiinflammatory drugs inhibiting prostanoid efflux: As easy as ABC?
Timothy D. Warner and Jane A. Mitchell
Proc Natl Acad Sci U S A. 2003 August 5; 100(16): 9108–9110. Published online 2003 July 28. doi: 10.1073/pnas.1733826100.
PMCID: PMC170879
Crystallizing ideas about Parkinson's disease
Mark R. Cookson
Proc Natl Acad Sci U S A. 2003 August 5; 100(16): 9111–9113. Published online 2003 July 28. doi: 10.1073/pnas.1633722100.
PMCID: PMC170880
Economics and the evolution of life histories
Alan R. Rogers
Proc Natl Acad Sci U S A. 2003 August 5; 100(16): 9114–9115. Published online 2003 July 28. doi: 10.1073/pnas.1733942100.
PMCID: PMC170881
Physical Sciences
Chemistry
A chemical approach for identifying O-GlcNAc-modified proteins in cells
David J. Vocadlo, Howard C. Hang, Eun-Ju Kim, John A. Hanover, and Carolyn R. Bertozzi
Proc Natl Acad Sci U S A. 2003 August 5; 100(16): 9116–9121. Published online 2003 July 21. doi: 10.1073/pnas.1632821100.
PMCID: PMC171382
Amplification of xenon NMR and MRI by remote detection
Adam J. Moulé, Megan M. Spence, Song-I Han, Juliette A. Seeley, Kimberly L. Pierce, Sunil Saxena, and Alexander Pines
Proc Natl Acad Sci U S A. 2003 August 5; 100(16): 9122–9127. Published online 2003 July 22. doi: 10.1073/pnas.1133497100.
PMCID: PMC170882
Statistics
Statistical significance for genomewide studies
John D. Storey and Robert Tibshirani
Proc Natl Acad Sci U S A. 2003 August 5; 100(16): 9440–9445. Published online 2003 July 25. doi: 10.1073/pnas.1530509100.
PMCID: PMC170937
Biological Sciences
Agricultural Sciences
Gene RB cloned from Solanum bulbocastanum confers broad spectrum resistance to potato late blight
Junqi Song, James M. Bradeen, S. Kristine Naess, John A. Raasch, Susan M. Wielgus, Geraldine T. Haberlach, Jia Liu, Hanhui Kuang, Sandra Austin-Phillips, C. Robin Buell, John P. Helgeson, and Jiming Jiang
Proc Natl Acad Sci U S A. 2003 August 5; 100(16): 9128–9133. Published online 2003 July 18. doi: 10.1073/pnas.1533501100.
PMCID: PMC170883
Applied Biological Sciences
Electrochemical interrogation of conformational changes as a reagentless method for the sequence-specific detection of DNA
Chunhai Fan, Kevin W. Plaxco, and Alan J. Heeger
Proc Natl Acad Sci U S A. 2003 August 5; 100(16): 9134–9137. Published online 2003 July 16. doi: 10.1073/pnas.1633515100.
PMCID: PMC170884
Conjugation to gold nanoparticles enhances polyethylenimine's transfer of plasmid DNA into mammalian cells
Mini Thomas and Alexander M. Klibanov
Proc Natl Acad Sci U S A. 2003 August 5; 100(16): 9138–9143. Published online 2003 July 28. doi: 10.1073/pnas.1233634100.
PMCID: PMC170885
Biochemistry
Zinc and mechanical prowess in the jaws of Nereis, a marine worm
Helga C. Lichtenegger, Thomas Schöberl, Janne T. Ruokolainen, Julie O. Cross, Steve M. Heald, Henrik Birkedal, J. Herbert Waite, and Galen D. Stucky
Proc Natl Acad Sci U S A. 2003 August 5; 100(16): 9144–9149. Published online 2003 July 28. doi: 10.1073/pnas.1632658100.
PMCID: PMC170886
A cytokinetic function of Drosophila ORC6 protein resides in a domain distinct from its replication activity
Igor N. Chesnokov, Olga N. Chesnokova, and Michael Botchan
Proc Natl Acad Sci U S A. 2003 August 5; 100(16): 9150–9155. Published online 2003 July 23. doi: 10.1073/pnas.1633580100.
PMCID: PMC170887
From the Cover:
Pheromone gland-specific fatty-acyl reductase of the silkmoth, Bombyx mori
Ken'ichi Moto, Toyoshi Yoshiga, Masanobu Yamamoto, Shunya Takahashi, Kazuhiro Okano, Tetsu Ando, Tadashi Nakata, and Shogo Matsumoto
Proc Natl Acad Sci U S A. 2003 August 5; 100(16): 9156–9161. Published online 2003 July 18. doi: 10.1073/pnas.1531993100.
PMCID: PMC170888
The lipoxygenase gene ALOXE3 implicated in skin differentiation encodes a hydroperoxide isomerase
Zheyong Yu, Claus Schneider, William E. Boeglin, Lawrence J. Marnett, and Alan R. Brash
Proc Natl Acad Sci U S A. 2003 August 5; 100(16): 9162–9167. Published online 2003 July 24. doi: 10.1073/pnas.1633612100.
PMCID: PMC170889
Coevolutionary patterns in plasminogen activation
Inna P. Gladysheva, Ryan B. Turner, Irina Y. Sazonova, Lin Liu, and Guy L. Reed
Proc Natl Acad Sci U S A. 2003 August 5; 100(16): 9168–9172. Published online 2003 July 23. doi: 10.1073/pnas.1631716100.
PMCID: PMC170890
Biosynthesis of isoprenoids: Crystal structure of 4-diphosphocytidyl-2C-methyl-d-erythritol kinase
Linda Miallau, Magnus S. Alphey, Lauris E. Kemp, Gordon A. Leonard, Sean M. McSweeney, Stefan Hecht, Adelbert Bacher, Wolfgang Eisenreich, Felix Rohdich, and William N. Hunter
Proc Natl Acad Sci U S A. 2003 August 5; 100(16): 9173–9178. Published online 2003 July 23. doi: 10.1073/pnas.1533425100.
PMCID: PMC170891
Molecular genetics and evolution of pheromone biosynthesis in Lepidoptera
Wendell L. Roelofs and Alejandro P. Rooney
Proc Natl Acad Sci U S A. 2003 August 5; 100(16): 9179–9184. Published online 2003 July 22. doi: 10.1073/pnas.1233767100.
PMCID: PMC170892
Polyserase-I, a human polyprotease with the ability to generate independent serine protease domains from a single translation product
Santiago Cal, Víctor Quesada, Cecilia Garabaya, and Carlos López-Otín
Proc Natl Acad Sci U S A. 2003 August 5; 100(16): 9185–9190. Published online 2003 July 28. doi: 10.1073/pnas.1633392100.
PMCID: PMC170893
Long-distance conformational changes in a protein engineered by modulated sequence duplication
Martin Sagermann, Leslie Gay, and Brian W. Matthews
Proc Natl Acad Sci U S A. 2003 August 5; 100(16): 9191–9195. Published online 2003 July 17. doi: 10.1073/pnas.1633549100.
PMCID: PMC170894
A biochemical rationale for the discrete behavior of nitroxyl and nitric oxide in the cardiovascular system
Katrina M. Miranda, Nazareno Paolocci, Tatsuo Katori, Douglas D. Thomas, Eleonora Ford, Michael D. Bartberger, Michael G. Espey, David A. Kass, Martin Feelisch, Jon M. Fukuto, and David A. Wink
Proc Natl Acad Sci U S A. 2003 August 5; 100(16): 9196–9201. Published online 2003 July 15. doi: 10.1073/pnas.1430507100.
PMCID: PMC170895
Differential binding of NAD+ and NADH allows the transcriptional corepressor carboxyl-terminal binding protein to serve as a metabolic sensor
Clark C. Fjeld, William T. Birdsong, and Richard H. Goodman
Proc Natl Acad Sci U S A. 2003 August 5; 100(16): 9202–9207. Published online 2003 July 18. doi: 10.1073/pnas.1633591100.
PMCID: PMC170896
A constitutively activated mutant of human soluble guanylyl cyclase (sGC): Implication for the mechanism of sGC activation
Emil Martin, Iraida Sharina, Alexander Kots, and Ferid Murad
Proc Natl Acad Sci U S A. 2003 August 5; 100(16): 9208–9213. Published online 2003 July 25. doi: 10.1073/pnas.1633590100.
PMCID: PMC170897
Crystal structure of an RNA·DNA hybrid reveals intermolecular intercalation: Dimer formation by base-pair swapping
Gye Won Han, Mary L. Kopka, David Langs, Michael R. Sawaya, and Richard E. Dickerson
Proc Natl Acad Sci U S A. 2003 August 5; 100(16): 9214–9219. Published online 2003 July 18. doi: 10.1073/pnas.1533326100.
PMCID: PMC170898
Role of extracellular subdomains of p185c-neu and the epidermal growth factor receptor in ligand-independent association and transactivation
Toru Kumagai, Makoto Katsumata, Akihiro Hasegawa, Keiji Furuuchi, Toshiki Funakoshi, Ichiro Kawase, and Mark I. Greene
Proc Natl Acad Sci U S A. 2003 August 5; 100(16): 9220–9225. Published online 2003 July 16. doi: 10.1073/pnas.1633546100.
PMCID: PMC170899
Inhibition of heregulin signaling by an aptamer that preferentially binds to the oligomeric form of human epidermal growth factor receptor-3
Chi-hong B. Chen, George A. Chernis, Van Q. Hoang, and Ralf Landgraf
Proc Natl Acad Sci U S A. 2003 August 5; 100(16): 9226–9231. Published online 2003 July 21. doi: 10.1073/pnas.1332660100.
PMCID: PMC170900
Toward a protein profile of Escherichia coli: Comparison to its transcription profile
Rebecca W. Corbin, Oleg Paliy, Feng Yang, Jeffrey Shabanowitz, Mark Platt, Charles E. Lyons, Jr., Karen Root, Jon McAuliffe, Michael I. Jordan, Sydney Kustu, Eric Soupene, and Donald F. Hunt
Proc Natl Acad Sci U S A. 2003 August 5; 100(16): 9232–9237. Published online 2003 July 23. doi: 10.1073/pnas.1533294100.
PMCID: PMC170901
Structure of the TDP-epi-vancosaminyltransferase GtfA from the chloroeremomycin biosynthetic pathway
Anne M. Mulichak, Heather C. Losey, Wei Lu, Zdzislaw Wawrzak, Christopher T. Walsh, and R. Michael Garavito
Proc Natl Acad Sci U S A. 2003 August 5; 100(16): 9238–9243. Published online 2003 July 21. doi: 10.1073/pnas.1233577100.
PMCID: PMC170902
The human multidrug resistance protein MRP4 functions as a prostaglandin efflux transporter and is inhibited by nonsteroidal antiinflammatory drugs
Glen Reid, Peter Wielinga, Noam Zelcer, Ingrid van der Heijden, Annemieke Kuil, Marcel de Haas, Jan Wijnholds, and Piet Borst
Proc Natl Acad Sci U S A. 2003 August 5; 100(16): 9244–9249. Published online 2003 June 30. doi: 10.1073/pnas.1033060100.
PMCID: PMC170903
Escherichia coli single-stranded DNA-binding protein mediates template recycling during transcription by bacteriophage N4 virion RNA polymerase
Elena K. Davydova and Lucia B. Rothman-Denes
Proc Natl Acad Sci U S A. 2003 August 5; 100(16): 9250–9255. Published online 2003 July 22. doi: 10.1073/pnas.1133325100.
PMCID: PMC170904
Biophysics
From the Cover:
The 1.1-Å resolution crystal structure of DJ-1, the protein mutated in autosomal recessive early onset Parkinson's disease
Mark A. Wilson, Jennifer L. Collins, Yaacov Hod, Dagmar Ringe, and Gregory A. Petsko
Proc Natl Acad Sci U S A. 2003 August 5; 100(16): 9256–9261. Published online 2003 July 10. doi: 10.1073/pnas.1133288100.
PMCID: PMC170905
From the Cover:
Retinal counterion switch in the photoactivation of the G protein-coupled receptor rhodopsin
Elsa C. Y. Yan, Manija A. Kazmi, Ziad Ganim, Jian-Min Hou, Douhai Pan, Belinda S. W. Chang, Thomas P. Sakmar, and Richard A. Mathies
Proc Natl Acad Sci U S A. 2003 August 5; 100(16): 9262–9267. Published online 2003 June 30. doi: 10.1073/pnas.1531970100.
PMCID: PMC170906
Crystal structure of NF-κB (p50)2 complexed to a high-affinity RNA aptamer
De-Bin Huang, Don Vu, Laura A. Cassiday, Jeff M. Zimmerman, L. James Maher, III, and Gourisankar Ghosh
Proc Natl Acad Sci U S A. 2003 August 5; 100(16): 9268–9273. Published online 2003 July 28. doi: 10.1073/pnas.1632011100.
PMCID: PMC170907
Cell organization in soft media due to active mechanosensing
I. B. Bischofs and U. S. Schwarz
Proc Natl Acad Sci U S A. 2003 August 5; 100(16): 9274–9279. Published online 2003 July 25. doi: 10.1073/pnas.1233544100.
PMCID: PMC170908
Visualizing infection of individual influenza viruses
Melike Lakadamyali, Michael J. Rust, Hazen P. Babcock, and Xiaowei Zhuang
Proc Natl Acad Sci U S A. 2003 August 5; 100(16): 9280–9285. Published online 2003 July 25. doi: 10.1073/pnas.0832269100.
PMCID: PMC170909
Importance of low-oligomeric-weight species for prion propagation in the yeast prion system Sup35/Hsp104
Saravanakumar Narayanan, Benjamin Bösl, Stefan Walter, and Bernd Reif
Proc Natl Acad Sci U S A. 2003 August 5; 100(16): 9286–9291. Published online 2003 July 22. doi: 10.1073/pnas.1233535100.
PMCID: PMC170910
Osmotic pressure inhibition of DNA ejection from phage
Alex Evilevitch, Laurence Lavelle, Charles M. Knobler, Eric Raspaud, and William M. Gelbart
Proc Natl Acad Sci U S A. 2003 August 5; 100(16): 9292–9295. Published online 2003 July 24. doi: 10.1073/pnas.1233721100.
PMCID: PMC170911
Controlling the size of nanoscale toroidal DNA condensates with static curvature and ionic strength
Christine C. Conwell, Igor D. Vilfan, and Nicholas V. Hud
Proc Natl Acad Sci U S A. 2003 August 5; 100(16): 9296–9301. Published online 2003 July 18. doi: 10.1073/pnas.1533135100.
PMCID: PMC170912
Single-molecule transition-state analysis of RNA folding
Gregory Bokinsky, David Rueda, Vinod K. Misra, Maria M. Rhodes, Andrew Gordus, Hazen P. Babcock, Nils G. Walter, and Xiaowei Zhuang
Proc Natl Acad Sci U S A. 2003 August 5; 100(16): 9302–9307. Published online 2003 July 17. doi: 10.1073/pnas.1133280100.
PMCID: PMC170913
A four-way junction accelerates hairpin ribozyme folding via a discrete intermediate
Elliot Tan, Timothy J. Wilson, Michelle K. Nahas, Robert M. Clegg, David M. J. Lilley, and Taekjip Ha
Proc Natl Acad Sci U S A. 2003 August 5; 100(16): 9308–9313. Published online 2003 July 25. doi: 10.1073/pnas.1233536100.
PMCID: PMC170914
The ATP-waiting conformation of rotating F1-ATPase revealed by single-pair fluorescence resonance energy transfer
Ryohei Yasuda, Tomoko Masaike, Kengo Adachi, Hiroyuki Noji, Hiroyasu Itoh, and Kazuhiko Kinosita, Jr.
Proc Natl Acad Sci U S A. 2003 August 5; 100(16): 9314–9318. Published online 2003 July 22. doi: 10.1073/pnas.1637860100.
PMCID: PMC170915
Dynamic reorganization of the functionally active ribosome explored by normal mode analysis and cryo-electron microscopy
Florence Tama, Mikel Valle, Joachim Frank, and Charles L. Brooks, III
Proc Natl Acad Sci U S A. 2003 August 5; 100(16): 9319–9323. Published online 2003 July 23. doi: 10.1073/pnas.1632476100.
PMCID: PMC170916
Cell Biology
Visualizing infection of individual influenza viruses
Melike Lakadamyali, Michael J. Rust, Hazen P. Babcock, and Xiaowei Zhuang
Proc Natl Acad Sci U S A. 2003 August 5; 100(16): 9280–9285. Published online 2003 July 25. doi: 10.1073/pnas.0832269100.
PMCID: PMC170909
Bad-deficient mice develop diffuse large B cell lymphoma
Ann M. Ranger, Jiping Zha, Hisashi Harada, Sandeep Robert Datta, Nika N. Danial, Andrew P. Gilmore, Jeffery L. Kutok, Michelle M. Le Beau, Michael E. Greenberg, and Stanley J. Korsmeyer
Proc Natl Acad Sci U S A. 2003 August 5; 100(16): 9324–9329. Published online 2003 July 22. doi: 10.1073/pnas.1533446100.
PMCID: PMC170917
Profiling receptor tyrosine kinase activation by using Ab microarrays
Ulrik B. Nielsen, Mike H. Cardone, Anthony J. Sinskey, Gavin MacBeath, and Peter K. Sorger
Proc Natl Acad Sci U S A. 2003 August 5; 100(16): 9330–9335. Published online 2003 July 22. doi: 10.1073/pnas.1633513100.
PMCID: PMC170918
Skeletal muscle engraftment potential of adult mouse skin side population cells
Federica Montanaro, Kalliopi Liadaki, Jay Volinski, Alan Flint, and Louis M. Kunkel
Proc Natl Acad Sci U S A. 2003 August 5; 100(16): 9336–9341. Published online 2003 July 28. doi: 10.1073/pnas.1133179100.
PMCID: PMC170919
The cell death regulator GRIM-19 is an inhibitor of signal transducer and activator of transcription 3
Jun Zhang, Jinbo Yang, Sanjit K. Roy, Silvia Tininini, Jiadi Hu, Jacqueline F. Bromberg, Valeria Poli, George R. Stark, and Dhananjaya V. Kalvakolanu
Proc Natl Acad Sci U S A. 2003 August 5; 100(16): 9342–9347. Published online 2003 July 16. doi: 10.1073/pnas.1633516100.
PMCID: PMC170920
Regulation of gonadotropin gene expression by Müllerian inhibiting substance
Grégoy Y. Bédécarrats, Francis H. O'Neill, Errol R. Norwitz, Ursula B. Kaiser, and Jose Teixeira
Proc Natl Acad Sci U S A. 2003 August 5; 100(16): 9348–9353. Published online 2003 July 23. doi: 10.1073/pnas.1633592100.
PMCID: PMC170921
The p53-dependent effects of macrophage migration inhibitory factor revealed by gene targeting
G. Fingerle-Rowson, O. Petrenko, C. N. Metz, T. G. Forsthuber, R. Mitchell, R. Huss, U. Moll, W. Müller, and R. Bucala
Proc Natl Acad Sci U S A. 2003 August 5; 100(16): 9354–9359. Published online 2003 July 23. doi: 10.1073/pnas.1533295100.
PMCID: PMC170922
Developmental Biology
Sox9 is required for determination of the chondrogenic cell lineage in the cranial neural crest
Yuko Mori-Akiyama, Haruhiko Akiyama, David H. Rowitch, and Benoit de Crombrugghe
Proc Natl Acad Sci U S A. 2003 August 5; 100(16): 9360–9365. Published online 2003 July 23. doi: 10.1073/pnas.1631288100.
PMCID: PMC170923
The serum response factor coactivator myocardin is required for vascular smooth muscle development
Shijie Li, Da-Zhi Wang, Zhigao Wang, James A. Richardson, and Eric N. Olson
Proc Natl Acad Sci U S A. 2003 August 5; 100(16): 9366–9370. Published online 2003 July 16. doi: 10.1073/pnas.1233635100.
PMCID: PMC170924
Transcriptional regulatory cascades in development: Initial rates, not steady state, determine network kinetics
Hamid Bolouri and Eric H. Davidson
Proc Natl Acad Sci U S A. 2003 August 5; 100(16): 9371–9376. Published online 2003 July 25. doi: 10.1073/pnas.1533293100.
PMCID: PMC170925
Ecology
Tufted puffin reproduction reveals ocean climate variability
Carina Gjerdrum, Anne M. J. Vallée, Colleen Cassady St. Clair, Douglas F. Bertram, John L. Ryder, and Gwylim S. Blackburn
Proc Natl Acad Sci U S A. 2003 August 5; 100(16): 9377–9382. Published online 2003 July 18. doi: 10.1073/pnas.1133383100.
PMCID: PMC170926
The nested assembly of plant–animal mutualistic networks
Jordi Bascompte, Pedro Jordano, Carlos J. Melián, and Jens M. Olesen
Proc Natl Acad Sci U S A. 2003 August 5; 100(16): 9383–9387. Published online 2003 July 24. doi: 10.1073/pnas.1633576100.
PMCID: PMC170927
Evolution
The genome sequence of Blochmannia floridanus: Comparative analysis of reduced genomes
Rosario Gil, Francisco J. Silva, Evelyn Zientz, François Delmotte, Fernando González-Candelas, Amparo Latorre, Carolina Rausell, Judith Kamerbeek, Jürgen Gadau, Bert Hölldobler, Roeland C. H. J. van Ham, Roy Gross, and Andrés Moya
Proc Natl Acad Sci U S A. 2003 August 5; 100(16): 9388–9393. Published online 2003 July 28. doi: 10.1073/pnas.1533499100.
PMCID: PMC170928
Worker caste polymorphism has a genetic basis in Acromyrmex leaf-cutting ants
William O. H. Hughes, Seirian Sumner, Steven Van Borm, and Jacobus J. Boomsma
Proc Natl Acad Sci U S A. 2003 August 5; 100(16): 9394–9397. Published online 2003 July 23. doi: 10.1073/pnas.1633701100.
PMCID: PMC170929
Microarray analysis of evolution of RNA viruses: Evidence of circulation of virulent highly divergent vaccine-derived polioviruses
Elena Cherkasova, Majid Laassri, Vladimir Chizhikov, Ekaterina Korotkova, Eugenia Dragunsky, Vadim I. Agol, and Konstantin Chumakov
Proc Natl Acad Sci U S A. 2003 August 5; 100(16): 9398–9403. Published online 2003 July 23. doi: 10.1073/pnas.1633511100.
PMCID: PMC170930
From the Cover:
Sexual dimorphism in Australopithecus afarensis was similar to that of modern humans
Philip L. Reno, Richard S. Meindl, Melanie A. McCollum, and C. Owen Lovejoy
Proc Natl Acad Sci U S A. 2003 August 5; 100(16): 9404–9409. Published online 2003 July 23. doi: 10.1073/pnas.1133180100.
PMCID: PMC170931
Genetics
An interacting network of T-box genes directs gene expression and fate in the zebrafish mesoderm
Lisa M. Goering, Kazuyuki Hoshijima, Barbara Hug, Brent Bisgrove, Andreas Kispert, and David Jonah Grunwald
Proc Natl Acad Sci U S A. 2003 August 5; 100(16): 9410–9415. Published online 2003 July 25. doi: 10.1073/pnas.1633548100.
PMCID: PMC170932
Suppressive function of androgen receptor in bone resorption
Hirotaka Kawano, Takashi Sato, Takashi Yamada, Takahiro Matsumoto, Keisuke Sekine, Tomoyuki Watanabe, Takashi Nakamura, Toru Fukuda, Kimihiro Yoshimura, Tatsuya Yoshizawa, Ken-ichi Aihara, Yoko Yamamoto, Yuko Nakamichi, Daniel Metzger, Pierre Chambon, Kozo Nakamura, Hiroshi Kawaguchi, and Shigeaki Kato
Proc Natl Acad Sci U S A. 2003 August 5; 100(16): 9416–9421. Published online 2003 July 18. doi: 10.1073/pnas.1533500100.
PMCID: PMC170933
Cloning and characterization of the Drosophila U7 small nuclear RNA
Zbigniew Dominski, Xiao-cui Yang, Matthew Purdy, and William F. Marzluff
Proc Natl Acad Sci U S A. 2003 August 5; 100(16): 9422–9427. Published online 2003 July 18. doi: 10.1073/pnas.1533509100.
PMCID: PMC170934
Protein–DNA interaction mapping using genomic tiling path microarrays in Drosophila
Ling V. Sun, Liang Chen, Frauke Greil, Nicolas Negre, Tong-Ruei Li, Giacomo Cavalli, Hongyu Zhao, Bas van Steensel, and Kevin P. White
Proc Natl Acad Sci U S A. 2003 August 5; 100(16): 9428–9433. Published online 2003 July 22. doi: 10.1073/pnas.1533393100.
PMCID: PMC170935
A new class of mutations reveals a novel function for the original phosphatidylinositol 3-kinase binding site
Y. Kate Hong, Aki Mikami, Brian Schaffhausen, Toni Jun, and Thomas M. Roberts
Proc Natl Acad Sci U S A. 2003 August 5; 100(16): 9434–9439. Published online 2003 July 24. doi: 10.1073/pnas.1432964100.
PMCID: PMC170936
Statistical significance for genomewide studies
John D. Storey and Robert Tibshirani
Proc Natl Acad Sci U S A. 2003 August 5; 100(16): 9440–9445. Published online 2003 July 25. doi: 10.1073/pnas.1530509100.
PMCID: PMC170937
Immunology
Structural insights into the antigenicity of myelin oligodendrocyte glycoprotein
Constanze Breithaupt, Anna Schubart, Hilke Zander, Arne Skerra, Robert Huber, Christopher Linington, and Uwe Jacob
Proc Natl Acad Sci U S A. 2003 August 5; 100(16): 9446–9451. Published online 2003 July 21. doi: 10.1073/pnas.1133443100.
PMCID: PMC170938
Stimulation of T cell autoreactivity by anomalous expression of NKG2D and its MIC ligands in rheumatoid arthritis
Veronika Groh, Anja Brühl, Hani El-Gabalawy, J. Lee Nelson, and Thomas Spies
Proc Natl Acad Sci U S A. 2003 August 5; 100(16): 9452–9457. Published online 2003 July 23. doi: 10.1073/pnas.1632807100.
PMCID: PMC170939
Shared modes of protection against poxvirus infection by attenuated and conventional smallpox vaccine viruses
Igor M. Belyakov, Patricia Earl, Amiran Dzutsev, Vladimir A. Kuznetsov, Michael Lemon, Linda S. Wyatt, James T. Snyder, Jeffrey D. Ahlers, Genoveffa Franchini, Bernard Moss, and Jay A. Berzofsky
Proc Natl Acad Sci U S A. 2003 August 5; 100(16): 9458–9463. Published online 2003 July 17. doi: 10.1073/pnas.1233578100.
PMCID: PMC170940
α-Galactosylceramide (KRN7000) suppression of chemical- and oncogene-dependent carcinogenesis
Yoshihiro Hayakawa, Stefania Rovero, Guido Forni, and Mark J. Smyth
Proc Natl Acad Sci U S A. 2003 August 5; 100(16): 9464–9469. Published online 2003 July 16. doi: 10.1073/pnas.1630663100.
PMCID: PMC170941
A Ras activation pathway dependent on Syk phosphorylation of protein kinase C
Yuko Kawakami, Jiro Kitaura, Libo Yao, Robert W. McHenry, Yu Kawakami, Alexandra C. Newton, Shin Kang, Roberta M. Kato, Michael Leitges, David J. Rawlings, and Toshiaki Kawakami
Proc Natl Acad Sci U S A. 2003 August 5; 100(16): 9470–9475. Published online 2003 July 24. doi: 10.1073/pnas.1633695100.
PMCID: PMC170942
Medical Sciences
Insig-1 “brakes” lipogenesis in adipocytes and inhibits differentiation of preadipocytes
Jinping Li, Kiyosumi Takaishi, William Cook, Sara Kay McCorkle, and Roger H. Unger
Proc Natl Acad Sci U S A. 2003 August 5; 100(16): 9476–9481. Published online 2003 July 17. doi: 10.1073/pnas.1133426100.
PMCID: PMC170943
Activated integrin αvβ3 cooperates with metalloproteinase MMP-9 in regulating migration of metastatic breast cancer cells
Melanie Rolli, Emilia Fransvea, Jan Pilch, Alan Saven, and Brunhilde Felding-Habermann
Proc Natl Acad Sci U S A. 2003 August 5; 100(16): 9482–9487. Published online 2003 July 21. doi: 10.1073/pnas.1633689100.
PMCID: PMC170944
Dehydroepiandrosterone (DHEA) prevents and reverses chronic hypoxic pulmonary hypertension
Sébastien Bonnet, Eric Dumas-de-La-Roque, Hugues Bégueret, Roger Marthan, Michael Fayon, Pierre Dos Santos, Jean-Pierre Savineau, and Etienne-Emile Baulieu
Proc Natl Acad Sci U S A. 2003 August 5; 100(16): 9488–9493. Published online 2003 July 23. doi: 10.1073/pnas.1633724100.
PMCID: PMC170945
Angiopoietin-related growth factor (AGF) promotes epidermal proliferation, remodeling, and regeneration
Yuichi Oike, Kunio Yasunaga, Yasuhiro Ito, Shun-ichiro Matsumoto, Hiromitsu Maekawa, Tohru Morisada, Fumio Arai, Naomi Nakagata, Motohiro Takeya, Yasuhiko Masuho, and Toshio Suda
Proc Natl Acad Sci U S A. 2003 August 5; 100(16): 9494–9499. Published online 2003 July 18. doi: 10.1073/pnas.1531901100.
PMCID: PMC170946
Mechanisms of HFE-induced regulation of iron homeostasis: Insights from the W81A HFE mutation
An-Sheng Zhang, Paige S. Davies, Hanqian L. Carlson, and Caroline A. Enns
Proc Natl Acad Sci U S A. 2003 August 5; 100(16): 9500–9505. Published online 2003 July 21. doi: 10.1073/pnas.1233675100.
PMCID: PMC170947
An activated receptor tyrosine kinase, TEL/PDGFβR, cooperates with AML1/ETO to induce acute myeloid leukemia in mice
Jay L. Grisolano, Julie O'Neal, Jennifer Cain, and Michael H. Tomasson
Proc Natl Acad Sci U S A. 2003 August 5; 100(16): 9506–9511. Published online 2003 July 24. doi: 10.1073/pnas.1531730100.
PMCID: PMC170948
Ligand-dependent and -independent effects of splice variant 1 of growth hormone-releasing hormone receptor
Hippokratis Kiaris, Ioulia Chatzistamou, Andrew V. Schally, Gabor Halmos, Jozsef L. Varga, Helen Koutselini, and Anastasios Kalofoutis
Proc Natl Acad Sci U S A. 2003 August 5; 100(16): 9512–9517. Published online 2003 July 16. doi: 10.1073/pnas.1533185100.
PMCID: PMC170949
A decline in the levels of progesterone receptor coactivators in the pregnant uterus at term may antagonize progesterone receptor function and contribute to the initiation of parturition
Jennifer C. Condon, Pancharatnam Jeyasuria, Julie M. Faust, James W. Wilson, and Carole R. Mendelson
Proc Natl Acad Sci U S A. 2003 August 5; 100(16): 9518–9523. Published online 2003 July 28. doi: 10.1073/pnas.1633616100.
PMCID: PMC170950
Repression of c-Myc and inhibition of G1 exit in cells conditionally overexpressing p300 that is not dependent on its histone acetyltransferase activity
Sudhakar Baluchamy, Hasan N. Rajabi, Rama Thimmapaya, Arunasalam Navaraj, and Bayar Thimmapaya
Proc Natl Acad Sci U S A. 2003 August 5; 100(16): 9524–9529. Published online 2003 July 25. doi: 10.1073/pnas.1633700100.
PMCID: PMC170951
Clusterin as a biomarker in murine and human intestinal neoplasia
Xiaodi Chen, Richard B. Halberg, William M. Ehrhardt, Jose Torrealba, and William F. Dove
Proc Natl Acad Sci U S A. 2003 August 5; 100(16): 9530–9535. Published online 2003 July 28. doi: 10.1073/pnas.1233633100.
PMCID: PMC170952
Microbiology
The role(s) of lipophosphoglycan (LPG) in the establishment of Leishmania major infections in mammalian hosts
Gerald F. Späth, L. A. Garraway, Salvatore J. Turco, and Stephen M. Beverley
Proc Natl Acad Sci U S A. 2003 August 5; 100(16): 9536–9541. Published online 2003 July 17. doi: 10.1073/pnas.1530604100.
PMCID: PMC170953
Identification of iron-activated and -repressed Fur-dependent genes by transcriptome analysis of Neisseria meningitidis group B
Renata Grifantini, Shite Sebastian, Elisabetta Frigimelica, Monia Draghi, Erika Bartolini, Alessandro Muzzi, Rino Rappuoli, Guido Grandi, and Caroline Attardo Genco
Proc Natl Acad Sci U S A. 2003 August 5; 100(16): 9542–9547. Published online 2003 July 25. doi: 10.1073/pnas.1033001100.
PMCID: PMC170954
Neuroscience
Differential regulation of microtubule dynamics by three- and four-repeat tau: Implications for the onset of neurodegenerative disease
Dulal Panda, Jonathan C. Samuel, Michelle Massie, Stuart C. Feinstein, and Leslie Wilson
Proc Natl Acad Sci U S A. 2003 August 5; 100(16): 9548–9553. Published online 2003 July 28. doi: 10.1073/pnas.1633508100.
PMCID: PMC170955
Glutamate carboxypeptidase II inhibition protects motor neurons from death in familial amyotrophic lateral sclerosis models
Ghanashyam D. Ghadge, Barbara S. Slusher, Amos Bodner, Mauro Dal Canto, Krystyna Wozniak, Ajit G. Thomas, Camilo Rojas, Takashi Tsukamoto, Pavel Majer, Richard J. Miller, Anna Liza Monti, and Raymond P. Roos
Proc Natl Acad Sci U S A. 2003 August 5; 100(16): 9554–9559. Published online 2003 July 22. doi: 10.1073/pnas.1530168100.
PMCID: PMC170956
Activity of the Caenorhabditis elegans UNC-86 POU transcription factor modulates olfactory sensitivity
Ji Ying Sze and Gary Ruvkun
Proc Natl Acad Sci U S A. 2003 August 5; 100(16): 9560–9565. Published online 2003 July 25. doi: 10.1073/pnas.1530752100.
PMCID: PMC170957
Nitric oxide negatively regulates mammalian adult neurogenesis
Michael A. Packer, Yuri Stasiv, Abdellatif Benraiss, Eva Chmielnicki, Alexander Grinberg, Heiner Westphal, Steven A. Goldman, and Grigori Enikolopov
Proc Natl Acad Sci U S A. 2003 August 5; 100(16): 9566–9571. Published online 2003 July 28. doi: 10.1073/pnas.1633579100.
PMCID: PMC170958
Neuronal depletion of calcium-dependent proteins in the dentate gyrus is tightly linked to Alzheimer's disease-related cognitive deficits
Jorge J. Palop, Brian Jones, Lisa Kekonius, Jeannie Chin, Gui-Qiu Yu, Jacob Raber, Eliezer Masliah, and Lennart Mucke
Proc Natl Acad Sci U S A. 2003 August 5; 100(16): 9572–9577. Published online 2003 July 24. doi: 10.1073/pnas.1133381100.
PMCID: PMC170959
Stimulation of NeuroD activity by huntingtin and huntingtin-associated proteins HAP1 and MLK2
Edoardo Marcora, Katherine Gowan, and Jacqueline E. Lee
Proc Natl Acad Sci U S A. 2003 August 5; 100(16): 9578–9583. Published online 2003 July 24. doi: 10.1073/pnas.1133382100.
PMCID: PMC170960
Bimodal circadian secretion of melatonin from the pineal gland in a living CBA mouse
Daiichiro Nakahara, Masato Nakamura, Masayuki Iigo, and Hitoshi Okamura
Proc Natl Acad Sci U S A. 2003 August 5; 100(16): 9584–9589. Published online 2003 July 21. doi: 10.1073/pnas.1631069100.
PMCID: PMC170961
Cathepsin L in secretory vesicles functions as a prohormone-processing enzyme for production of the enkephalin peptide neurotransmitter
Sukkid Yasothornsrikul, Doron Greenbaum, Katalin F. Medzihradszky, Thomas Toneff, Richard Bundey, Ruthellen Miller, Birgit Schilling, Ivonne Petermann, Jessica Dehnert, Anna Logvinova, Paul Goldsmith, John M. Neveu, William S. Lane, Bradford Gibson, Thomas Reinheckel, Christoph Peters, Matthew Bogyo, and Vivian Hook
Proc Natl Acad Sci U S A. 2003 August 5; 100(16): 9590–9595. Published online 2003 July 17. doi: 10.1073/pnas.1531542100.
PMCID: PMC170962
Executive and social behaviors under nicotinic receptor regulation
Sylvie Granon, Philippe Faure, and Jean-Pierre Changeux
Proc Natl Acad Sci U S A. 2003 August 5; 100(16): 9596–9601. Published online 2003 July 22. doi: 10.1073/pnas.1533498100.
PMCID: PMC170963
Two previously undescribed members of the mouse CPEB family of genes and their inducible expression in the principal cell layers of the hippocampus
Martin Theis, Kausik Si, and Eric R. Kandel
Proc Natl Acad Sci U S A. 2003 August 5; 100(16): 9602–9607. Published online 2003 July 18. doi: 10.1073/pnas.1133424100.
PMCID: PMC170964
Pharmacology
Prediction of clinical drug efficacy by classification of drug-induced genomic expression profiles in vitro
Erik C. Gunther, David J. Stone, Robert W. Gerwien, Patricia Bento, and Melvyn P. Heyes
Proc Natl Acad Sci U S A. 2003 August 5; 100(16): 9608–9613. Published online 2003 July 17. doi: 10.1073/pnas.1632587100.
PMCID: PMC170965
Estrogen receptor-α mediates the brain antiinflammatory activity of estradiol
Elisabetta Vegeto, Silvia Belcredito, Sabrina Etteri, Serena Ghisletti, Alessia Brusadelli, Clara Meda, Andrée Krust, Sonia Dupont, Paolo Ciana, Pierre Chambon, and Adriana Maggi
Proc Natl Acad Sci U S A. 2003 August 5; 100(16): 9614–9619. Published online 2003 July 23. doi: 10.1073/pnas.1531957100.
PMCID: PMC170966
Physiology
A kinase-regulated mechanism controls CFTR channel gating by disrupting bivalent PDZ domain interactions
Viswanathan Raghuram, Hayley Hormuth, and J. Kevin Foskett
Proc Natl Acad Sci U S A. 2003 August 5; 100(16): 9620–9625. Published online 2003 July 24. doi: 10.1073/pnas.1633250100.
PMCID: PMC170967
Plant Biology
AthPEX10, a nuclear gene essential for peroxisome and storage organelle formation during Arabidopsis embryogenesis
Uwe Schumann, Gerhard Wanner, Marten Veenhuis, Markus Schmid, and Christine Gietl
Proc Natl Acad Sci U S A. 2003 August 5; 100(16): 9626–9631. Published online 2003 July 25. doi: 10.1073/pnas.1633697100.
PMCID: PMC170968
Short interfering RNA-mediated interference of gene expression and viral DNA accumulation in cultured plant cells
Ramachandran Vanitharani, Padmanabhan Chellappan, and Claude M. Fauquet
Proc Natl Acad Sci U S A. 2003 August 5; 100(16): 9632–9636. Published online 2003 July 28. doi: 10.1073/pnas.1733874100.
PMCID: PMC170969
Social Sciences
Social Sciences
From the Cover:
Rethinking the evolutionary theory of aging: Transfers, not births, shape senescence in social species
Ronald D. Lee
Proc Natl Acad Sci U S A. 2003 August 5; 100(16): 9637–9642. Published online 2003 July 23. doi: 10.1073/pnas.1530303100.
PMCID: PMC170970
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