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Volume 100(13);  June 24, 2003
Commentaries
Horizontal gene transfer in eukaryotic algal evolution
Jason Raymond and Robert E. Blankenship
Proc Natl Acad Sci U S A. 2003 June 24; 100(13): 7419–7420. Published online 2003 June 16. doi: 10.1073/pnas.1533212100.
PMCID: PMC164597
What happens if the room at the bottom runs out? A close look at small water pores
Helmut Grubmüller
Proc Natl Acad Sci U S A. 2003 June 24; 100(13): 7421–7422. Published online 2003 June 16. doi: 10.1073/pnas.1533175100.
PMCID: PMC164598
Bacterial cell division spirals into control
Zemer Gitai and Lucy Shapiro
Proc Natl Acad Sci U S A. 2003 June 24; 100(13): 7423–7424. Published online 2003 June 16. doi: 10.1073/pnas.1332806100.
PMCID: PMC164599
Retuning the misfiring brain
Randolph J. Nudo
Proc Natl Acad Sci U S A. 2003 June 24; 100(13): 7425–7427. Published online 2003 June 16. doi: 10.1073/pnas.1533210100.
PMCID: PMC164600
Replication of the herpes simplex virus genome: Does it really go around in circles?
Rozanne M. Sandri-Goldin
Proc Natl Acad Sci U S A. 2003 June 24; 100(13): 7428–7429. Published online 2003 June 16. doi: 10.1073/pnas.1432875100.
PMCID: PMC164601
Brain repair by cell replacement and regeneration
Olle Lindvall and Ron McKay
Proc Natl Acad Sci U S A. 2003 June 24; 100(13): 7430–7431. Published online 2003 June 16. doi: 10.1073/pnas.1332673100.
PMCID: PMC164602
Physical Sciences
Applied Mathematics
A pattern analysis of the second Rehnquist U.S. Supreme Court
Lawrence Sirovich
Proc Natl Acad Sci U S A. 2003 June 24; 100(13): 7432–7437. Published online 2003 June 23. doi: 10.1073/pnas.1132164100.
PMCID: PMC164603
Applied Physical Sciences
Prediction and measurement of an autoregulatory genetic module
Farren J. Isaacs, Jeff Hasty, Charles R. Cantor, and J. J. Collins
Proc Natl Acad Sci U S A. 2003 June 24; 100(13): 7714–7719. Published online 2003 June 13. doi: 10.1073/pnas.1332628100.
PMCID: PMC164653
Geology
Nanobacteria-like calcite single crystals at the surface of the Tataouine meteorite
Karim Benzerara, Nicolas Menguy, François Guyot, Christian Dominici, and Philippe Gillet
Proc Natl Acad Sci U S A. 2003 June 24; 100(13): 7438–7442. Published online 2003 June 5. doi: 10.1073/pnas.0832464100.
PMCID: PMC164604
Statistics
Modeling of DNA microarray data by using physical properties of hybridization
G. A. Held, G. Grinstein, and Y. Tu
Proc Natl Acad Sci U S A. 2003 June 24; 100(13): 7575–7580. Published online 2003 June 13. doi: 10.1073/pnas.0832500100.
PMCID: PMC164628
Biological Sciences
Agricultural Sciences
Mapping of quantitative trait loci controlling trypanotolerance in a cross of tolerant West African N'Dama and susceptible East African Boran cattle
O. Hanotte, Y. Ronin, M. Agaba, P. Nilsson, A. Gelhaus, R. Horstmann, Y. Sugimoto, S. Kemp, J. Gibson, A. Korol, M. Soller, and A. Teale
Proc Natl Acad Sci U S A. 2003 June 24; 100(13): 7443–7448. Published online 2003 June 12. doi: 10.1073/pnas.1232392100.
PMCID: PMC164605
Applied Biological Sciences
Direct molecular haplotyping of long-range genomic DNA with M1-PCR
Chunming Ding and Charles R. Cantor
Proc Natl Acad Sci U S A. 2003 June 24; 100(13): 7449–7453. Published online 2003 June 11. doi: 10.1073/pnas.1232475100.
PMCID: PMC164606
Biochemistry
Carbohydrate-dependent signaling from the phosphatidylglucoside-based microdomain induces granulocytic differentiation of HL60 cells
Yasuko Nagatsuka, Miki Hara-Yokoyama, Takeshi Kasama, Masataka Takekoshi, Fumiko Maeda, Seiji Ihara, Shigeyoshi Fujiwara, Eriko Ohshima, Kumiko Ishii, Toshihide Kobayashi, Kazufumi Shimizu, and Yoshio Hirabayashi
Proc Natl Acad Sci U S A. 2003 June 24; 100(13): 7454–7459. Published online 2003 June 11. doi: 10.1073/pnas.1232503100.
PMCID: PMC164607
Determination of the membrane topology of Ost4p and its subunit interactions in the oligosaccharyltransferase complex in Saccharomyces cerevisiae
Hyun Kim, Qi Yan, Gunnar von Heijne, Gregory A. Caputo, and William J. Lennarz
Proc Natl Acad Sci U S A. 2003 June 24; 100(13): 7460–7464. Published online 2003 June 16. doi: 10.1073/pnas.1332735100.
PMCID: PMC164608
Suppressed catalytic activity of base excision repair enzymes on rotationally positioned uracil in nucleosomes
Brian C. Beard, Samuel H. Wilson, and Michael J. Smerdon
Proc Natl Acad Sci U S A. 2003 June 24; 100(13): 7465–7470. Published online 2003 June 10. doi: 10.1073/pnas.1330328100.
PMCID: PMC164609
RNA recognition by designed peptide fusion creates "artificial" tRNA synthetase
Magali Frugier, Richard Giegé, and Paul Schimmel
Proc Natl Acad Sci U S A. 2003 June 24; 100(13): 7471–7475. Published online 2003 June 9. doi: 10.1073/pnas.1332771100.
PMCID: PMC164610
Validation of the hexose transporter of Plasmodium falciparum as a novel drug target
Thierry Joët, Ursula Eckstein-Ludwig, Christophe Morin, and Sanjeev Krishna
Proc Natl Acad Sci U S A. 2003 June 24; 100(13): 7476–7479. Published online 2003 June 5. doi: 10.1073/pnas.1330865100.
PMCID: PMC164611
Efficient biotinylation and single-step purification of tagged transcription factors in mammalian cells and transgenic mice
Ernie de Boer, Patrick Rodriguez, Edgar Bonte, Jeroen Krijgsveld, Eleni Katsantoni, Albert Heck, Frank Grosveld, and John Strouboulis
Proc Natl Acad Sci U S A. 2003 June 24; 100(13): 7480–7485. Published online 2003 June 11. doi: 10.1073/pnas.1332608100.
PMCID: PMC164612
Selenium-deficient diet enhances protein oxidation and affects methionine sulfoxide reductase (MsrB) protein level in certain mouse tissues
Jackob Moskovitz and Earl R. Stadtman
Proc Natl Acad Sci U S A. 2003 June 24; 100(13): 7486–7490. Published online 2003 June 5. doi: 10.1073/pnas.1332607100.
PMCID: PMC164613
Membrane-binding and activation mechanism of PTEN
Sudipto Das, Jack E. Dixon, and Wonhwa Cho
Proc Natl Acad Sci U S A. 2003 June 24; 100(13): 7491–7496. Published online 2003 June 13. doi: 10.1073/pnas.0932835100.
PMCID: PMC164614
High-resolution structure of RNase P protein from Thermotoga maritima
Alexei V. Kazantsev, Angelika A. Krivenko, Daniel J. Harrington, Richard J. Carter, Stephen R. Holbrook, Paul D. Adams, and Norman R. Pace
Proc Natl Acad Sci U S A. 2003 June 24; 100(13): 7497–7502. Published online 2003 June 10. doi: 10.1073/pnas.0932597100.
PMCID: PMC164615
A lupus-like syndrome develops in mice lacking the Ro 60-kDa protein, a major lupus autoantigen
Dahai Xue, Hong Shi, James D. Smith, Xinguo Chen, Dennis A. Noe, Tommy Cedervall, Derek D. Yang, Elizabeth Eynon, Douglas E. Brash, Michael Kashgarian, Richard A. Flavell, and Sandra L. Wolin
Proc Natl Acad Sci U S A. 2003 June 24; 100(13): 7503–7508. Published online 2003 June 3. doi: 10.1073/pnas.0832411100.
PMCID: PMC164616
The terminal nucleotide of the Mu genome controls catalysis of DNA strand transfer
Ilana Goldhaber-Gordon, Michael H. Early, and Tania A. Baker
Proc Natl Acad Sci U S A. 2003 June 24; 100(13): 7509–7514. Published online 2003 June 9. doi: 10.1073/pnas.0832468100.
PMCID: PMC164617
Human acetyl-CoA carboxylase 1 gene: Presence of three promoters and heterogeneity at the 5′-untranslated mRNA region
Jianqiang Mao, Subrahmanyam S. Chirala, and Salih J. Wakil
Proc Natl Acad Sci U S A. 2003 June 24; 100(13): 7515–7520. Published online 2003 June 16. doi: 10.1073/pnas.1332670100.
PMCID: PMC164618
Small nucleolar RNA interference induced by antisense or double-stranded RNA in trypanosomatids
Xue-hai Liang, Qing Liu, and Shulamit Michaeli
Proc Natl Acad Sci U S A. 2003 June 24; 100(13): 7521–7526. Published online 2003 June 13. doi: 10.1073/pnas.1332001100.
PMCID: PMC164619
The evolution of vertebrate blood coagulation as viewed from a comparison of puffer fish and sea squirt genomes
Yong Jiang and Russell F. Doolittle
Proc Natl Acad Sci U S A. 2003 June 24; 100(13): 7527–7532. Published online 2003 June 13. doi: 10.1073/pnas.0932632100.
PMCID: PMC164620
Direct activation of the apoptosis machinery as a mechanism to target cancer cells
Jack T. Nguyen and James A. Wells
Proc Natl Acad Sci U S A. 2003 June 24; 100(13): 7533–7538. Published online 2003 June 13. doi: 10.1073/pnas.1031631100.
PMCID: PMC164621
An unusual type IB topoisomerase from African trypanosomes
Annette L. Bodley, Asit K. Chakraborty, Suji Xie, Christian Burri, and Theresa A. Shapiro
Proc Natl Acad Sci U S A. 2003 June 24; 100(13): 7539–7544. Published online 2003 June 16. doi: 10.1073/pnas.1330762100.
PMCID: PMC164622
A simple energy-conserving system: Proton reduction coupled to proton translocation
Rajat Sapra, Karine Bagramyan, and Michael W. W. Adams
Proc Natl Acad Sci U S A. 2003 June 24; 100(13): 7545–7550. Published online 2003 June 5. doi: 10.1073/pnas.1331436100.
PMCID: PMC164623
Spreading of Sir3 protein in cells with severe histone H3 hypoacetylation
Arnold Kristjuhan, Birgitte Ø. Wittschieben, Jane Walker, Douglas Roberts, Bradley R. Cairns, and Jesper Q. Svejstrup
Proc Natl Acad Sci U S A. 2003 June 24; 100(13): 7551–7556. Published online 2003 June 9. doi: 10.1073/pnas.1332299100.
PMCID: PMC164624
A multistep mechanism for the activation of rearrangement in the immune system
Yanhong Ji, Jianmin Zhang, Alfred Ian Lee, Howard Cedar, and Yehudit Bergman
Proc Natl Acad Sci U S A. 2003 June 24; 100(13): 7557–7562. Published online 2003 June 11. doi: 10.1073/pnas.0932635100.
PMCID: PMC164625
Protein tyrosine phosphatase RQ is a phosphatidylinositol phosphatase that can regulate cell survival and proliferation
A. Oganesian, M. Poot, G. Daum, S. A. Coats, M. B. Wright, R. A. Seifert, and D. F. Bowen-Pope
Proc Natl Acad Sci U S A. 2003 June 24; 100(13): 7563–7568. Published online 2003 June 11. doi: 10.1073/pnas.1336511100.
PMCID: PMC164626
Insulin signaling through Akt/protein kinase B analyzed by small interfering RNA-mediated gene silencing
Zhen Y. Jiang, Qiong L. Zhou, Kerri A. Coleman, My Chouinard, Queta Boese, and Michael P. Czech
Proc Natl Acad Sci U S A. 2003 June 24; 100(13): 7569–7574. Published online 2003 June 13. doi: 10.1073/pnas.1332633100.
PMCID: PMC164627
Biophysics
Modeling of DNA microarray data by using physical properties of hybridization
G. A. Held, G. Grinstein, and Y. Tu
Proc Natl Acad Sci U S A. 2003 June 24; 100(13): 7575–7580. Published online 2003 June 13. doi: 10.1073/pnas.0832500100.
PMCID: PMC164628
From the Cover:
The coiled-coil of the human Rad50 DNA repair protein contains specific segments of increased flexibility
John van Noort, Thijn van der Heijden, Martijn de Jager, Claire Wyman, Roland Kanaar, and Cees Dekker
Proc Natl Acad Sci U S A. 2003 June 24; 100(13): 7581–7586. Published online 2003 June 12. doi: 10.1073/pnas.1330706100.
PMCID: PMC164629
Understanding folding and design: Replica-exchange simulations of ``Trp-cage'' miniproteins
Jed W. Pitera and William Swope
Proc Natl Acad Sci U S A. 2003 June 24; 100(13): 7587–7592. Published online 2003 June 13. doi: 10.1073/pnas.1330954100.
PMCID: PMC164630
The interplay of glycosylation and disulfide formation influences fibrillization in a prion protein fragment
Carlos J. Bosques and Barbara Imperiali
Proc Natl Acad Sci U S A. 2003 June 24; 100(13): 7593–7598. Published online 2003 June 12. doi: 10.1073/pnas.1232504100.
PMCID: PMC164631
Developing an energy landscape for the novel function of a (β/α)8 barrel: Ammonia conduction through HisF
Rommie Amaro, Emad Tajkhorshid, and Zaida Luthey-Schulten
Proc Natl Acad Sci U S A. 2003 June 24; 100(13): 7599–7604. Published online 2003 June 10. doi: 10.1073/pnas.1331150100.
PMCID: PMC164632
Single-molecule detection of DNA hybridization
Mukta Singh-Zocchi, Sanhita Dixit, Vassili Ivanov, and Giovanni Zocchi
Proc Natl Acad Sci U S A. 2003 June 24; 100(13): 7605–7610. Published online 2003 June 13. doi: 10.1073/pnas.1337215100.
PMCID: PMC164633
Fast gating in the Shaker K+ channel and the energy landscape of activation
Daniel Sigg, Francisco Bezanilla, and Enrico Stefani
Proc Natl Acad Sci U S A. 2003 June 24; 100(13): 7611–7615. Published online 2003 June 12. doi: 10.1073/pnas.1332409100.
PMCID: PMC164634
Tetraspanin CD151 regulates α6β1 integrin adhesion strengthening
Jan Lammerding, Alexander R. Kazarov, Hayden Huang, Richard T. Lee, and Martin E. Hemler
Proc Natl Acad Sci U S A. 2003 June 24; 100(13): 7616–7621. Published online 2003 June 12. doi: 10.1073/pnas.1337546100.
PMCID: PMC164635
Allosteric control of internal electron transfer in cytochrome cd1 nitrite reductase
Ole Farver, Peter M. H. Kroneck, Walter G. Zumft, and Israel Pecht
Proc Natl Acad Sci U S A. 2003 June 24; 100(13): 7622–7625. Published online 2003 June 11. doi: 10.1073/pnas.0932693100.
PMCID: PMC164636
Cell Biology
TSG101 interaction with HRS mediates endosomal trafficking and receptor down-regulation
Quan Lu, Lila Weiqiao Hope, Michael Brasch, Christoph Reinhard, and Stanley N. Cohen
Proc Natl Acad Sci U S A. 2003 June 24; 100(13): 7626–7631. Published online 2003 June 11. doi: 10.1073/pnas.0932599100.
PMCID: PMC164637
Synthetic small molecules that control stem cell fate
Sheng Ding, Tom Y. H. Wu, Achim Brinker, Eric C. Peters, Wooyoung Hur, Nathanael S. Gray, and Peter G. Schultz
Proc Natl Acad Sci U S A. 2003 June 24; 100(13): 7632–7637. Published online 2003 June 6. doi: 10.1073/pnas.0732087100.
PMCID: PMC164638
The Notch ligand Delta1 is sequentially cleaved by an ADAM protease and γ-secretase
Emmanuelle Six, Delphine Ndiaye, Yacine Laâbi, Christel Brou, Neetu Gupta-Rossi, Alain Israël, and Frédérique Logeat
Proc Natl Acad Sci U S A. 2003 June 24; 100(13): 7638–7643. Published online 2003 June 6. doi: 10.1073/pnas.1230693100.
PMCID: PMC164639
Mdm20 protein functions with Nat3 protein to acetylate Tpm1 protein and regulate tropomyosin–actin interactions in budding yeast
Jason M. Singer and Janet M. Shaw
Proc Natl Acad Sci U S A. 2003 June 24; 100(13): 7644–7649. Published online 2003 June 13. doi: 10.1073/pnas.1232343100.
PMCID: PMC164640
Ecology
Additive effects of simulated climate changes, elevated CO2, and nitrogen deposition on grassland diversity
Erika S. Zavaleta, M. Rebecca Shaw, Nona R. Chiariello, Harold A. Mooney, and Christopher B. Field
Proc Natl Acad Sci U S A. 2003 June 24; 100(13): 7650–7654. Published online 2003 June 16. doi: 10.1073/pnas.0932734100.
PMCID: PMC164642
Masquerading as self? Endoparasitic Strepsiptera (Insecta) enclose themselves in host-derived epidermal bag
Jeyaraney Kathirithamby, Larry D. Ross, and J. Spencer Johnston
Proc Natl Acad Sci U S A. 2003 June 24; 100(13): 7655–7659. Published online 2003 June 3. doi: 10.1073/pnas.1131999100.
PMCID: PMC164643
Nutrient loading and consumers: Agents of change in open-coast macrophyte assemblages
Karina J. Nielsen
Proc Natl Acad Sci U S A. 2003 June 24; 100(13): 7660–7665. Published online 2003 June 9. doi: 10.1073/pnas.0932534100.
PMCID: PMC164644
Evolution
Origin and evolutionary process of the CNS elucidated by comparative genomics analysis of planarian ESTs
Katsuhiko Mineta, Masumi Nakazawa, Francesc Cebrià, Kazuho Ikeo, Kiyokazu Agata, and Takashi Gojobori
Proc Natl Acad Sci U S A. 2003 June 24; 100(13): 7666–7671. Published online 2003 June 11. doi: 10.1073/pnas.1332513100.
PMCID: PMC164645
Human and mouse genomic sequences reveal extensive breakpoint reuse in mammalian evolution
Pavel Pevzner and Glenn Tesler
Proc Natl Acad Sci U S A. 2003 June 24; 100(13): 7672–7677. Published online 2003 June 16. doi: 10.1073/pnas.1330369100.
PMCID: PMC164646
From the Cover:
Lateral gene transfer and the evolution of plastid-targeted proteins in the secondary plastid-containing alga Bigelowiella natans
John M. Archibald, Matthew B. Rogers, Michael Toop, Ken-ichiro Ishida, and Patrick J. Keeling
Proc Natl Acad Sci U S A. 2003 June 24; 100(13): 7678–7683. Published online 2003 May 30. doi: 10.1073/pnas.1230951100.
PMCID: PMC164647
Genera of the human lineage
Camilo J. Cela-Conde and Francisco J. Ayala
Proc Natl Acad Sci U S A. 2003 June 24; 100(13): 7684–7689. Published online 2003 June 6. doi: 10.1073/pnas.0832372100.
PMCID: PMC164648
Expression of prestin-homologous solute carrier (SLC26) in auditory organs of nonmammalian vertebrates and insects
Thomas Weber, Martin C. Göpfert, Harald Winter, Ulrike Zimmermann, Hanni Kohler, Alexandra Meier, Oliver Hendrich, Karin Rohbock, Daniel Robert, and Marlies Knipper
Proc Natl Acad Sci U S A. 2003 June 24; 100(13): 7690–7695. Published online 2003 June 2. doi: 10.1073/pnas.1330557100.
PMCID: PMC164649
Genetics
End-sequence profiling: Sequence-based analysis of aberrant genomes
Stanislav Volik, Shaying Zhao, Koei Chin, John H. Brebner, David R. Herndon, Quanzhou Tao, David Kowbel, Guiqing Huang, Anna Lapuk, Wen-Lin Kuo, Gregg Magrane, Pieter de Jong, Joe W. Gray, and Colin Collins
Proc Natl Acad Sci U S A. 2003 June 24; 100(13): 7696–7701. Published online 2003 June 4. doi: 10.1073/pnas.1232418100.
PMCID: PMC164650
Detailed map of a cis-regulatory input function
Y. Setty, A. E. Mayo, M. G. Surette, and U. Alon
Proc Natl Acad Sci U S A. 2003 June 24; 100(13): 7702–7707. Published online 2003 June 12. doi: 10.1073/pnas.1230759100.
PMCID: PMC164651
Comparative sequencing of human and chimpanzee MHC class I regions unveils insertions/deletions as the major path to genomic divergence
Tatsuya Anzai, Takashi Shiina, Natsuki Kimura, Kazuyo Yanagiya, Sakae Kohara, Atsuko Shigenari, Tetsushi Yamagata, Jerzy K. Kulski, Taeko K. Naruse, Yoshifumi Fujimori, Yasuhito Fukuzumi, Masaaki Yamazaki, Hiroyuki Tashiro, Chie Iwamoto, Yumi Umehara, Tadashi Imanishi, Alice Meyer, Kazuho Ikeo, Takashi Gojobori, Seiamak Bahram, and Hidetoshi Inoko
Proc Natl Acad Sci U S A. 2003 June 24; 100(13): 7708–7713. Published online 2003 June 10. doi: 10.1073/pnas.1230533100.
PMCID: PMC164652
Prediction and measurement of an autoregulatory genetic module
Farren J. Isaacs, Jeff Hasty, Charles R. Cantor, and J. J. Collins
Proc Natl Acad Sci U S A. 2003 June 24; 100(13): 7714–7719. Published online 2003 June 13. doi: 10.1073/pnas.1332628100.
PMCID: PMC164653
piggyBac-based insertional mutagenesis in the presence of stably integrated P elements in Drosophila
Udo Häcker, Sverker Nystedt, Mojgan Padash Barmchi, Carsten Horn, and Ernst A. Wimmer
Proc Natl Acad Sci U S A. 2003 June 24; 100(13): 7720–7725. Published online 2003 June 11. doi: 10.1073/pnas.1230526100.
PMCID: PMC164654
Germ-line transgenesis of the Tc1/mariner superfamily transposon Minos in Ciona intestinalis
Yasunori Sasakura, Satoko Awazu, Shota Chiba, and Nori Satoh
Proc Natl Acad Sci U S A. 2003 June 24; 100(13): 7726–7730. Published online 2003 June 3. doi: 10.1073/pnas.1230736100.
PMCID: PMC164655
Runx3 and Runx1 are required for CD8 T cell development during thymopoiesis
Eilon Woolf, Cuiying Xiao, Ofer Fainaru, Joseph Lotem, Dalia Rosen, Varda Negreanu, Yael Bernstein, Dalia Goldenberg, Ori Brenner, Gideon Berke, Ditsa Levanon, and Yoram Groner
Proc Natl Acad Sci U S A. 2003 June 24; 100(13): 7731–7736. Published online 2003 June 9. doi: 10.1073/pnas.1232420100.
PMCID: PMC164656
From latent disseminated cells to overt metastasis: Genetic analysis of systemic breast cancer progression
Oleg Schmidt-Kittler, Thomas Ragg, Angela Daskalakis, Martin Granzow, Andre Ahr, Thomas J. F. Blankenstein, Manfred Kaufmann, Joachim Diebold, Hans Arnholdt, Peter Müller, Joachim Bischoff, Detlev Harich, Günter Schlimok, Gert Riethmüller, Roland Eils, and Christoph A. Klein
Proc Natl Acad Sci U S A. 2003 June 24; 100(13): 7737–7742. Published online 2003 June 13. doi: 10.1073/pnas.1331931100.
PMCID: PMC164657
Targeted cytosine methylation for in vivo detection of protein–DNA interactions
Christopher D. Carvin, Archana Dhasarathy, Laurie B. Friesenhahn, Walter J. Jessen, and Michael P. Kladde
Proc Natl Acad Sci U S A. 2003 June 24; 100(13): 7743–7748. Published online 2003 June 13. doi: 10.1073/pnas.1332672100.
PMCID: PMC164658
Immunology
T-bet is required for optimal production of IFN-γ and antigen-specific T cell activation by dendritic cells
Geanncarlo Lugo-Villarino, Roberto Maldonado-López, Richard Possemato, Cristina Peñaranda, and Laurie H. Glimcher
Proc Natl Acad Sci U S A. 2003 June 24; 100(13): 7749–7754. Published online 2003 June 11. doi: 10.1073/pnas.1332767100.
PMCID: PMC164659
Differential proteasomal processing of hydrophobic and hydrophilic protein regions: Contribution to cytotoxic T lymphocyte epitope clustering in HIV-1-Nef
Maria Lucchiari-Hartz, Viv Lindo, Niclas Hitziger, Simone Gaedicke, Loredana Saveanu, Peter M. van Endert, Fiona Greer, Klaus Eichmann, and Gabriele Niedermann
Proc Natl Acad Sci U S A. 2003 June 24; 100(13): 7755–7760. Published online 2003 June 16. doi: 10.1073/pnas.1232228100.
PMCID: PMC164660
Mast cells disrupt epithelial barrier function during enteric nematode infection
Jacqueline R. McDermott, Ruth E. Bartram, Pamela A. Knight, Hugh R. P. Miller, David R. Garrod, and Richard K. Grencis
Proc Natl Acad Sci U S A. 2003 June 24; 100(13): 7761–7766. Published online 2003 June 9. doi: 10.1073/pnas.1231488100.
PMCID: PMC164661
Stepwise cytoskeletal polarization as a series of checkpoints in innate but not adaptive cytolytic killing
Christoph Wülfing, Bozidar Purtic, Jennifer Klem, and John D. Schatzle
Proc Natl Acad Sci U S A. 2003 June 24; 100(13): 7767–7772. Published online 2003 June 11. doi: 10.1073/pnas.1336920100.
PMCID: PMC164662
Inducible nitric oxide synthase expression inhibition by adenovirus E1A
Wangsen Cao, Clare Bao, and Charles J. Lowenstein
Proc Natl Acad Sci U S A. 2003 June 24; 100(13): 7773–7778. Published online 2003 June 13. doi: 10.1073/pnas.1337185100.
PMCID: PMC164663
Genes encoding putative natural killer cell C-type lectin receptors in teleostean fishes
Akie Sato, Werner E. Mayer, Peter Overath, and Jan Klein
Proc Natl Acad Sci U S A. 2003 June 24; 100(13): 7779–7784. Published online 2003 June 11. doi: 10.1073/pnas.1235938100.
PMCID: PMC164664
Medical Sciences
Regression of established tumors and metastases by potent vascular endothelial growth factor blockade
Jianzhong Huang, Jason S. Frischer, Anna Serur, Angela Kadenhe, Akiko Yokoi, Kimberly W. McCrudden, Tamara New, Kathleen O'Toole, Stephanie Zabski, John S. Rudge, Jocelyn Holash, George D. Yancopoulos, Darrell J. Yamashiro, and Jessica J. Kandel
Proc Natl Acad Sci U S A. 2003 June 24; 100(13): 7785–7790. Published online 2003 June 12. doi: 10.1073/pnas.1432908100.
PMCID: PMC164665
Expression of utrophin A mRNA correlates with the oxidative capacity of skeletal muscle fiber types and is regulated by calcineurin/NFAT signaling
Joe V. Chakkalakal, Mark A. Stocksley, Mary-Ann Harrison, Lindsay M. Angus, Julie Deschênes-Furry, Simon St-Pierre, Lynn A. Megeney, Eva R. Chin, Robin N. Michel, and Bernard J. Jasmin
Proc Natl Acad Sci U S A. 2003 June 24; 100(13): 7791–7796. Published online 2003 June 13. doi: 10.1073/pnas.0932671100.
PMCID: PMC164666
Caspase 8 small interfering RNA prevents acute liver failure in mice
Lars Zender, Sebastian Hütker, Christian Liedtke, Hans Ludger Tillmann, Steffen Zender, Bettina Mundt, Morlen Waltemathe, Thomas Gösling, Peer Flemming, Nisar Peter Malek, Christian Trautwein, Michael Peter Manns, Florian Kühnel, and Stefan Kubicka
Proc Natl Acad Sci U S A. 2003 June 24; 100(13): 7797–7802. Published online 2003 June 16. doi: 10.1073/pnas.1330920100.
PMCID: PMC164667
Oncogenic potential of TASK3 (Kcnk9) depends on K+ channel function
Lin Pei, Ofer Wiser, Anthony Slavin, David Mu, Scott Powers, Lily Yeh Jan, and Timothy Hoey
Proc Natl Acad Sci U S A. 2003 June 24; 100(13): 7803–7807. Published online 2003 June 2. doi: 10.1073/pnas.1232448100.
PMCID: PMC164668
Myoblasts transplanted into rat infarcted myocardium are functionally isolated from their host
Bertrand Léobon, Isabelle Garcin, Philippe Menasché, Jean-Thomas Vilquin, Etienne Audinat, and Serge Charpak
Proc Natl Acad Sci U S A. 2003 June 24; 100(13): 7808–7811. Published online 2003 June 12. doi: 10.1073/pnas.1232447100.
PMCID: PMC164669
Transglutaminase 2-/- mice reveal a phagocytosis-associated crosstalk between macrophages and apoptotic cells
Zsuzsa Szondy, Zsolt Sarang, Péter Molnár, Tamás Németh, Mauro Piacentini, Pier Giorgio Mastroberardino, Laura Falasca, Daniel Aeschlimann, Judit Kovács, Ildikó Kiss, Éva Szegezdi, Gabriella Lakos, Éva Rajnavölgyi, Paul J. Birckbichler, Gerry Melino, and László Fésüs
Proc Natl Acad Sci U S A. 2003 June 24; 100(13): 7812–7817. Published online 2003 June 16. doi: 10.1073/pnas.0832466100.
PMCID: PMC164670
Epigenetic inactivation of CHFR in human tumors
Minoru Toyota, Yasushi Sasaki, Ayumi Satoh, Kazuhiro Ogi, Takefumi Kikuchi, Hiromu Suzuki, Hiroaki Mita, Nobuyuki Tanaka, Fumio Itoh, Jean-Pierre J. Issa, Kam-Wing Jair, Kornel E. Schuebel, Kohzoh Imai, and Takashi Tokino
Proc Natl Acad Sci U S A. 2003 June 24; 100(13): 7818–7823. Published online 2003 June 16. doi: 10.1073/pnas.1337066100.
PMCID: PMC164671
Deletion of histidine triad nucleotide-binding protein 1/PKC-interacting protein in mice enhances cell growth and carcinogenesis
Tao Su, Masumi Suzui, Lei Wang, Chyuan-Sheng Lin, Wang-Qiu Xing, and I. Bernard Weinstein
Proc Natl Acad Sci U S A. 2003 June 24; 100(13): 7824–7829. Published online 2003 June 16. doi: 10.1073/pnas.1332160100.
PMCID: PMC164672
Discovery of a fusion kinase in EOL-1 cells and idiopathic hypereosinophilic syndrome
John H. Griffin, Joey Leung, Rebecca J. Bruner, Michael A. Caligiuri, and Roger Briesewitz
Proc Natl Acad Sci U S A. 2003 June 24; 100(13): 7830–7835. Published online 2003 June 13. doi: 10.1073/pnas.0932698100.
PMCID: PMC164673
CD40 ligand is a critical effector of Epstein–Barr virus in host cell survival and transformation
Ken-Ichi Imadome, Masaki Shirakata, Norio Shimizu, Shigeaki Nonoyama, and Yuji Yamanashi
Proc Natl Acad Sci U S A. 2003 June 24; 100(13): 7836–7840. Published online 2003 June 12. doi: 10.1073/pnas.1231363100.
PMCID: PMC164674
Prostate intraepithelial neoplasia induced by prostate restricted Akt activation: The MPAKT model
Pradip K. Majumder, Jen Jen Yeh, Daniel J. George, Phillip G. Febbo, Jennifer Kum, Qi Xue, Rachel Bikoff, Hongfeng Ma, Philip W. Kantoff, Todd R. Golub, Massimo Loda, and William R. Sellers
Proc Natl Acad Sci U S A. 2003 June 24; 100(13): 7841–7846. Published online 2003 June 10. doi: 10.1073/pnas.1232229100.
PMCID: PMC164675
Maspin expression inhibits osteolysis, tumor growth, and angiogenesis in a model of prostate cancer bone metastasis
Michael L. Cher, Hector R. Biliran, Jr., Sunita Bhagat, Yonghong Meng, Mingxin Che, Jaron Lockett, Judith Abrams, Rafael Fridman, Michael Zachareas, and Shijie Sheng
Proc Natl Acad Sci U S A. 2003 June 24; 100(13): 7847–7852. Published online 2003 June 3. doi: 10.1073/pnas.1331360100.
PMCID: PMC164676
Expression profiles of acute lymphoblastic and myeloblastic leukemias with ALL-1 rearrangements
T. Rozovskaia, O. Ravid-Amir, S. Tillib, G. Getz, E. Feinstein, H. Agrawal, A. Nagler, E. F. Rappaport, I. Issaeva, Y. Matsuo, U. R. Kees, T. Lapidot, F. Lo Coco, R. Foa, A. Mazo, T. Nakamura, C. M. Croce, G. Cimino, E. Domany, and E. Canaani
Proc Natl Acad Sci U S A. 2003 June 24; 100(13): 7853–7858. Published online 2003 June 2. doi: 10.1073/pnas.1132115100.
PMCID: PMC164677
Pronounced reduction in adenoma recurrence associated with aspirin use and a polymorphism in the ornithine decarboxylase gene
María Elena Martínez, Thomas G. O'Brien, Kimberly E. Fultz, Naveen Babbar, Hagit Yerushalmi, Ning Qu, Yongjun Guo, David Boorman, Janine Einspahr, David S. Alberts, and Eugene W. Gerner
Proc Natl Acad Sci U S A. 2003 June 24; 100(13): 7859–7864. Published online 2003 June 16. doi: 10.1073/pnas.1332465100.
PMCID: PMC164678
Microbiology
From the Cover:
Division site selection in Escherichia coli involves dynamic redistribution of Min proteins within coiled structures that extend between the two cell poles
Yu-Ling Shih, Trung Le, and Lawrence Rothfield
Proc Natl Acad Sci U S A. 2003 June 24; 100(13): 7865–7870. Published online 2003 May 23. doi: 10.1073/pnas.1232225100.
PMCID: PMC164679
Relationship of herpes simplex virus genome configuration to productive and persistent infections
Sara A. Jackson and Neal A. DeLuca
Proc Natl Acad Sci U S A. 2003 June 24; 100(13): 7871–7876. Published online 2003 June 9. doi: 10.1073/pnas.1230643100.
PMCID: PMC164680
The complete genome sequence of Mycobacterium bovis
Thierry Garnier, Karin Eiglmeier, Jean-Christophe Camus, Nadine Medina, Huma Mansoor, Melinda Pryor, Stephanie Duthoy, Sophie Grondin, Celine Lacroix, Christel Monsempe, Sylvie Simon, Barbara Harris, Rebecca Atkin, Jon Doggett, Rebecca Mayes, Lisa Keating, Paul R. Wheeler, Julian Parkhill, Bart G. Barrell, Stewart T. Cole, Stephen V. Gordon, and R. Glyn Hewinson
Proc Natl Acad Sci U S A. 2003 June 24; 100(13): 7877–7882. Published online 2003 June 3. doi: 10.1073/pnas.1130426100.
PMCID: PMC164681
Gene function analysis in environmental isolates: The nif regulon of the strict iron oxidizing bacterium Leptospirillum ferrooxidans
Víctor Parro and Mercedes Moreno-Paz
Proc Natl Acad Sci U S A. 2003 June 24; 100(13): 7883–7888. Published online 2003 June 13. doi: 10.1073/pnas.1230487100.
PMCID: PMC164682
Crystal structure of the SOS cell division inhibitor SulA and in complex with FtsZ
Suzanne C. Cordell, Elva J. H. Robinson, and Jan Löwe
Proc Natl Acad Sci U S A. 2003 June 24; 100(13): 7889–7894. Published online 2003 June 13. doi: 10.1073/pnas.1330742100.
PMCID: PMC164683
Recombinant lymphocytic choriomeningitis virus expressing vesicular stomatitis virus glycoprotein
Daniel D. Pinschewer, Mar Perez, Ana B. Sanchez, and Juan Carlos de la Torre
Proc Natl Acad Sci U S A. 2003 June 24; 100(13): 7895–7900. Published online 2003 June 13. doi: 10.1073/pnas.1332709100.
PMCID: PMC164684
The complete genome sequence of the carcinogenic bacterium Helicobacter hepaticus
Sebastian Suerbaum, Christine Josenhans, Torsten Sterzenbach, Bernd Drescher, Petra Brandt, Monica Bell, Marcus Dröge, Berthold Fartmann, Hans-Peter Fischer, Zhongming Ge, Andrea Hörster, Rudi Holland, Kerstin Klein, Jochen König, Ludwig Macko, George L. Mendz, Gerald Nyakatura, David B. Schauer, Zeli Shen, Jacqueline Weber, Matthias Frosch, and James G. Fox
Proc Natl Acad Sci U S A. 2003 June 24; 100(13): 7901–7906. Published online 2003 June 16. doi: 10.1073/pnas.1332093100.
PMCID: PMC164685
Alginate is not a significant component of the extracellular polysaccharide matrix of PA14 and PAO1 Pseudomonas aeruginosa biofilms
Daniel J. Wozniak, Timna J. O. Wyckoff, Melissa Starkey, Rebecca Keyser, Parastoo Azadi, George A. O'Toole, and Matthew R. Parsek
Proc Natl Acad Sci U S A. 2003 June 24; 100(13): 7907–7912. Published online 2003 June 16. doi: 10.1073/pnas.1231792100.
PMCID: PMC164686
A newly discovered cholesteryl galactoside from Borrelia burgdorferi
Gil Ben-Menachem, Joanna Kubler-Kielb, Bruce Coxon, Alfred Yergey, and Rachel Schneerson
Proc Natl Acad Sci U S A. 2003 June 24; 100(13): 7913–7918. Published online 2003 June 10. doi: 10.1073/pnas.1232451100.
PMCID: PMC164687
Neuroscience
Selective impairment of hippocampal neurogenesis by chronic alcoholism: Protective effects of an antioxidant
Daniel G. Herrera, Almudena G. Yagüe, Siv Johnsen-Soriano, Francisco Bosch-Morell, Lucía Collado-Morente, Maria Muriach, Francisco J. Romero, and J. Manuel García-Verdugo
Proc Natl Acad Sci U S A. 2003 June 24; 100(13): 7919–7924. Published online 2003 June 5. doi: 10.1073/pnas.1230907100.
PMCID: PMC164688
From the Cover:
Evidence for neurogenesis in the adult mammalian substantia nigra
Ming Zhao, Stefan Momma, Kioumars Delfani, Marie Carlén, Robert M. Cassidy, Clas B. Johansson, Hjalmar Brismar, Oleg Shupliakov, Jonas Frisén, and Ann Marie Janson
Proc Natl Acad Sci U S A. 2003 June 24; 100(13): 7925–7930. Published online 2003 June 5. doi: 10.1073/pnas.1131955100.
PMCID: PMC164689
Reset of human neocortical oscillations during a working memory task
D. S. Rizzuto, J. R. Madsen, E. B. Bromfield, A. Schulze-Bonhage, D. Seelig, R. Aschenbrenner-Scheibe, and M. J. Kahana
Proc Natl Acad Sci U S A. 2003 June 24; 100(13): 7931–7936. Published online 2003 June 5. doi: 10.1073/pnas.0732061100.
PMCID: PMC164690
Connectivity optimization and the positioning of cortical areas
Vitaly A. Klyachko and Charles F. Stevens
Proc Natl Acad Sci U S A. 2003 June 24; 100(13): 7937–7941. Published online 2003 June 9. doi: 10.1073/pnas.0932745100.
PMCID: PMC164691
From the Cover:
Effective behavioral treatment of focal hand dystonia in musicians alters somatosensory cortical organization
Victor Candia, Christian Wienbruch, Thomas Elbert, Brigitte Rockstroh, and William Ray
Proc Natl Acad Sci U S A. 2003 June 24; 100(13): 7942–7946. Published online 2003 May 27. doi: 10.1073/pnas.1231193100.
PMCID: PMC164692
Impaired neuropathic pain responses in mice lacking the chemokine receptor CCR2
Catherine Abbadie, Jill A. Lindia, Anne Marie Cumiskey, Larry B. Peterson, John S. Mudgett, Ellen K. Bayne, Julie A. DeMartino, D. Euan MacIntyre, and Michael J. Forrest
Proc Natl Acad Sci U S A. 2003 June 24; 100(13): 7947–7952. Published online 2003 June 13. doi: 10.1073/pnas.1331358100.
PMCID: PMC164693
Mifepristone (RU486) protects Purkinje cells from cell death in organotypic slice cultures of postnatal rat and mouse cerebellum
A. M. Ghoumari, I. Dusart, M. El-Etr, F. Tronche, C. Sotelo, M. Schumacher, and E.-E. Baulieu
Proc Natl Acad Sci U S A. 2003 June 24; 100(13): 7953–7958. Published online 2003 June 16. doi: 10.1073/pnas.1332667100.
PMCID: PMC164694
Male Japanese quails with female brains do not show male sexual behaviors
Manfred Gahr
Proc Natl Acad Sci U S A. 2003 June 24; 100(13): 7959–7964. Published online 2003 June 11. doi: 10.1073/pnas.1335934100.
PMCID: PMC164695
Impairment of reward-related learning by cholinergic cell ablation in the striatum
Yasuji Kitabatake, Takatoshi Hikida, Dai Watanabe, Ira Pastan, and Shigetada Nakanishi
Proc Natl Acad Sci U S A. 2003 June 24; 100(13): 7965–7970. Published online 2003 June 11. doi: 10.1073/pnas.1032899100.
PMCID: PMC164696
Pharmacology
A low molecular weight mimic of the Toll/IL-1 receptor/resistance domain inhibits IL-1 receptor-mediated responses
Tamas Bartfai, M. Margarita Behrens, Svetlana Gaidarova, Janell Pemberton, Alexander Shivanyuk, and Julius Rebek, Jr
Proc Natl Acad Sci U S A. 2003 June 24; 100(13): 7971–7976. Published online 2003 June 10. doi: 10.1073/pnas.0932746100.
PMCID: PMC164697
Systematic discovery of multicomponent therapeutics
Alexis A. Borisy, Peter J. Elliott, Nicole W. Hurst, Margaret S. Lee, Joseph Lehár, E. Roydon Price, George Serbedzija, Grant R. Zimmermann, Michael A. Foley, Brent R. Stockwell, and Curtis T. Keith
Proc Natl Acad Sci U S A. 2003 June 24; 100(13): 7977–7982. Published online 2003 June 10. doi: 10.1073/pnas.1337088100.
PMCID: PMC164698
Evidence that mouse brain neuropathy target esterase is a lysophospholipase
Gary B. Quistad, Carrolee Barlow, Christopher J. Winrow, Susan E. Sparks, and John E. Casida
Proc Natl Acad Sci U S A. 2003 June 24; 100(13): 7983–7987. Published online 2003 June 12. doi: 10.1073/pnas.1232473100.
PMCID: PMC164699
Physiology
Mechanotransduction and flow across the endothelial glycocalyx
Sheldon Weinbaum, Xiaobing Zhang, Yuefeng Han, Hans Vink, and Stephen C. Cowin
Proc Natl Acad Sci U S A. 2003 June 24; 100(13): 7988–7995. Published online 2003 June 16. doi: 10.1073/pnas.1332808100.
PMCID: PMC164700
Effect of insulin on human skeletal muscle mitochondrial ATP production, protein synthesis, and mRNA transcripts
Craig S. Stump, Kevin R. Short, Maureen L. Bigelow, Jill M. Schimke, and K. Sreekumaran Nair
Proc Natl Acad Sci U S A. 2003 June 24; 100(13): 7996–8001. Published online 2003 June 13. doi: 10.1073/pnas.1332551100.
PMCID: PMC164701
Structural determinant of TRPV1 desensitization interacts with calmodulin
Mitsuko Numazaki, Tomoko Tominaga, Kumiko Takeuchi, Namie Murayama, Hidenori Toyooka, and Makoto Tominaga
Proc Natl Acad Sci U S A. 2003 June 24; 100(13): 8002–8006. Published online 2003 June 13. doi: 10.1073/pnas.1337252100.
PMCID: PMC164702
Plant Biology
Comparative genomics of Physcomitrella patens gametophytic transcriptome and Arabidopsis thaliana: Implication for land plant evolution
Tomoaki Nishiyama, Tomomichi Fujita, Tadasu Shin-I, Motoaki Seki, Hiroyo Nishide, Ikuo Uchiyama, Asako Kamiya, Piero Carninci, Yoshihide Hayashizaki, Kazuo Shinozaki, Yuji Kohara, and Mitsuyasu Hasebe
Proc Natl Acad Sci U S A. 2003 June 24; 100(13): 8007–8012. Published online 2003 June 13. doi: 10.1073/pnas.0932694100.
PMCID: PMC164703
Function and glycosylation of plant-derived antiviral monoclonal antibody
Kisung Ko, Yoram Tekoah, Pauline M. Rudd, David J. Harvey, Raymond A. Dwek, Sergei Spitsin, Cathleen A. Hanlon, Charles Rupprecht, Bernhard Dietzschold, Maxim Golovkin, and Hilary Koprowski
Proc Natl Acad Sci U S A. 2003 June 24; 100(13): 8013–8018. Published online 2003 June 10. doi: 10.1073/pnas.0832472100.
PMCID: PMC164704
Control of in vitro organogenesis by cyclin-dependent kinase activities in plants
Masatoshi Yamaguchi, Hisashi Kato, Shigeo Yoshida, Saburo Yamamura, Hirofumi Uchimiya, and Masaaki Umeda
Proc Natl Acad Sci U S A. 2003 June 24; 100(13): 8019–8023. Published online 2003 June 10. doi: 10.1073/pnas.1332637100.
PMCID: PMC164705
Physical interaction between RRS1-R, a protein conferring resistance to bacterial wilt, and PopP2, a type III effector targeted to the plant nucleus
Laurent Deslandes, Jocelyne Olivier, Nemo Peeters, Dong Xin Feng, Manirath Khounlotham, Christian Boucher, Imre Somssich, Stéphane Genin, and Yves Marco
Proc Natl Acad Sci U S A. 2003 June 24; 100(13): 8024–8029. Published online 2003 June 3. doi: 10.1073/pnas.1230660100.
PMCID: PMC164706
Psychology
Social interaction shapes babbling: Testing parallels between birdsong and speech
Michael H. Goldstein, Andrew P. King, and Meredith J. West
Proc Natl Acad Sci U S A. 2003 June 24; 100(13): 8030–8035. Published online 2003 June 13. doi: 10.1073/pnas.1332441100.
PMCID: PMC164707
Social Sciences
Anthropology
Genera of the human lineage
Camilo J. Cela-Conde and Francisco J. Ayala
Proc Natl Acad Sci U S A. 2003 June 24; 100(13): 7684–7689. Published online 2003 June 6. doi: 10.1073/pnas.0832372100.
PMCID: PMC164648
Corrections
Proc Natl Acad Sci U S A. 2003 June 24; 100(13): 8036. doi: 10.1073/pnas.1432848100.
PMCID: PMC164708
Corrects: Christine Lonjou, et al. Linkage disequilibrium in human populations. Proc Natl Acad Sci U S A. 2003 May 13; 100(10): 6069–6074.
Proc Natl Acad Sci U S A. 2003 June 24; 100(13): 8036. doi: 10.1073/pnas.1332736100.
PMCID: PMC164709
Corrects: Alfred H. Schinkel, et al. Normal viability and altered pharmacokinetics in mice lacking mdr1-type (drug-transporting) P-glycoproteins. Proc Natl Acad Sci U S A. 1997 April 15; 94(8): 4028–4033.
Proc Natl Acad Sci U S A. 2003 June 24; 100(13): 8036. doi: 10.1073/pnas.1332662100.
PMCID: PMC164710
Corrects: Éva Mezey, et al. Transplanted bone marrow generates new neurons in human brains. Proc Natl Acad Sci U S A. 2003 February 4; 100(3): 1364–1369.
Proc Natl Acad Sci U S A. 2003 June 24; 100(13): 8037. doi: 10.1073/pnas.1432896100.
PMCID: PMC164711
Corrects: Sudarshan Rajagopal, et al. Crystal structure of a photoactive yellow protein from a sensor histidine kinase: Conformational variability and signal transduction. Proc Natl Acad Sci U S A. 2003 February 18; 100(4): 1649–1654.
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