| | This journal provides immediate access to some articles. Colloquium Papers Auditory neuroscience: Development, transduction, and integration A. J. Hudspeth and Masakazu Konishi Proc Natl Acad Sci U S A. 2000 October 24; 97(22): 11690–11691. PMCID: PMC34336 Notch signaling in the development of the inner ear: Lessons
from Drosophila Mark Eddison, Isabelle Le Roux, and Julian Lewis Proc Natl Acad Sci U S A. 2000 October 24; 97(22): 11692–11699. PMCID: PMC34337 Molecular genetics of pattern formation in the inner ear: Do
compartment boundaries play a role? John V. Brigande, Amy E. Kiernan, Xiaoying Gao, Laurie E. Iten, and Donna M. Fekete Proc Natl Acad Sci U S A. 2000 October 24; 97(22): 11700–11706. PMCID: PMC34338 Patterning of the mammalian cochlea Raquel Cantos, Laura K. Cole, Dario Acampora, Antonio Simeone, and Doris K. Wu Proc Natl Acad Sci U S A. 2000 October 24; 97(22): 11707–11713. PMCID: PMC34339 Cellular studies of auditory hair cell regeneration in birds Jennifer S. Stone and Edwin W Rubel Proc Natl Acad Sci U S A. 2000 October 24; 97(22): 11714–11721. PMCID: PMC34340 Hair cell recovery in mitotically blocked cultures of the
bullfrog saccule Richard A. Baird, Miriam D. Burton, David S. Fashena, and Rebecca A. Naeger Proc Natl Acad Sci U S A. 2000 October 24; 97(22): 11722–11729. PMCID: PMC34341 Two mechanisms for transducer adaptation in vertebrate
hair cells Jeffrey R. Holt and David P. Corey Proc Natl Acad Sci U S A. 2000 October 24; 97(22): 11730–11735. PMCID: PMC34342 Cochlear mechanisms from a phylogenetic viewpoint Geoffrey A. Manley Proc Natl Acad Sci U S A. 2000 October 24; 97(22): 11736–11743. PMCID: PMC34343 Mechanical bases of frequency tuning and neural excitation at the
base of the cochlea: Comparison of basilar-membrane vibrations and
auditory-nerve-fiber responses in chinchilla Mario A. Ruggero, S. Shyamla Narayan, Andrei N. Temchin, and Alberto Recio Proc Natl Acad Sci U S A. 2000 October 24; 97(22): 11744–11750. PMCID: PMC34344 The spatial and temporal representation of a tone on the guinea
pig basilar membrane K. E. Nilsen and I. J. Russell Proc Natl Acad Sci U S A. 2000 October 24; 97(22): 11751–11758. PMCID: PMC34345 Molecular mechanisms of sound amplification in the
mammalian cochlea Jonathan F. Ashmore, Gwénaëlle S.
G. Géléoc, and Lene Harbott Proc Natl Acad Sci U S A. 2000 October 24; 97(22): 11759–11764. PMCID: PMC34346 Putting ion channels to work: Mechanoelectrical transduction,
adaptation, and amplification by hair cells A. J. Hudspeth, Y. Choe, A. D. Mehta, and P. Martin Proc Natl Acad Sci U S A. 2000 October 24; 97(22): 11765–11772. PMCID: PMC34347 Detection of synchrony in the activity of auditory nerve fibers
by octopus cells of the mammalian cochlear nucleus Donata Oertel, Ramazan Bal, Stephanie M. Gardner, Philip H. Smith, and Philip X. Joris Proc Natl Acad Sci U S A. 2000 October 24; 97(22): 11773–11779. PMCID: PMC34348 Linear and nonlinear pathways of spectral information
transmission in the cochlear nucleus Jane J. Yu and Eric D. Young Proc Natl Acad Sci U S A. 2000 October 24; 97(22): 11780–11786. PMCID: PMC34349 Cellular mechanisms for resolving phase ambiguity in the owl's
inferior colliculus José Luis Peña and Masakazu Konishi Proc Natl Acad Sci U S A. 2000 October 24; 97(22): 11787–11792. PMCID: PMC34350 Subdivisions of auditory cortex and processing streams
in primates Jon H. Kaas and Troy A. Hackett Proc Natl Acad Sci U S A. 2000 October 24; 97(22): 11793–11799. PMCID: PMC34351 Mechanisms and streams for processing of “what” and
“where” in auditory cortex Josef P. Rauschecker and Biao Tian Proc Natl Acad Sci U S A. 2000 October 24; 97(22): 11800–11806. PMCID: PMC34352 The corticofugal system for hearing: Recent progress Nobuo Suga, Enquan Gao, Yunfeng Zhang, Xiaofeng Ma, and John F. Olsen Proc Natl Acad Sci U S A. 2000 October 24; 97(22): 11807–11814. PMCID: PMC34353 Traces of learning in the auditory localization pathway Eric I. Knudsen, Weimin Zheng, and William M. DeBello Proc Natl Acad Sci U S A. 2000 October 24; 97(22): 11815–11820. PMCID: PMC34354 Plasticity in the neural coding of auditory space in the
mammalian brain Andrew J. King, Carl H. Parsons, and David R. Moore Proc Natl Acad Sci U S A. 2000 October 24; 97(22): 11821–11828. PMCID: PMC34355 Spatial processing in the auditory cortex of the macaque monkey Gregg H. Recanzone Proc Natl Acad Sci U S A. 2000 October 24; 97(22): 11829–11835. PMCID: PMC34356 Song selectivity and sensorimotor signals in vocal learning
and production Michele M. Solis, Michael S. Brainard, Neal A. Hessler, and Allison J. Doupe Proc Natl Acad Sci U S A. 2000 October 24; 97(22): 11836–11842. PMCID: PMC34357 On cortical coding of vocal communication sounds in primates Xiaoqin Wang Proc Natl Acad Sci U S A. 2000 October 24; 97(22): 11843–11849. PMCID: PMC34358 A new view of language acquisition Patricia K. Kuhl Proc Natl Acad Sci U S A. 2000 October 24; 97(22): 11850–11857. PMCID: PMC34178 Commentaries The self-same beat of time's wide wings Vincent M. Cassone Proc Natl Acad Sci U S A. 2000 October 24; 97(22): 11677–11679. PMCID: PMC34331 Can allosteric regulation be predicted from structure? Ernesto Freire Proc Natl Acad Sci U S A. 2000 October 24; 97(22): 11680–11682. PMCID: PMC34332 Channel structure and drug-induced cardiac arrhythmias Robert S. Kass and Candido Cabo Proc Natl Acad Sci U S A. 2000 October 24; 97(22): 11683–11684. PMCID: PMC34333 Facilitating structural transitions in DNA Michael Waring Proc Natl Acad Sci U S A. 2000 October 24; 97(22): 11685–11687. PMCID: PMC34334 Ecological mechanisms of extinction Steven R. Beissinger Proc Natl Acad Sci U S A. 2000 October 24; 97(22): 11688–11689. PMCID: PMC34335 Physical Sciences Applied Physical Sciences Attributes of an alluvial river and their relation to water
policy and management William J. Trush, Scott M. McBain, and Luna B. Leopold Proc Natl Acad Sci U S A. 2000 October 24; 97(22): 11858–11863. PMCID: PMC17259 Chemistry Atmospheric aerosols as prebiotic chemical reactors Christopher M. Dobson, G. Barney Ellison, Adrian F. Tuck, and Veronica Vaida Proc Natl Acad Sci U S A. 2000 October 24; 97(22): 11864–11868. Published online 2000 October 17. PMCID: PMC17260 Neuromelanin biosynthesis is driven by excess cytosolic
catecholamines not accumulated by synaptic vesicles David Sulzer, Johanna Bogulavsky, Kristin E. Larsen, Gerald Behr, Erdem Karatekin, Mark H. Kleinman, Nicholas Turro, David Krantz, Robert H. Edwards, Lloyd A. Greene, and Luigi Zecca Proc Natl Acad Sci U S A. 2000 October 24; 97(22): 11869–11874. PMCID: PMC17261 Geology Fossilized high pressure from the Earth's deep interior: The
coesite-in-diamond barometer Nikolai V. Sobolev, Boris A. Fursenko, Sergei V. Goryainov, Jinfu Shu, Russell J. Hemley, Ho-kwang Mao, and Francis R. Boyd Proc Natl Acad Sci U S A. 2000 October 24; 97(22): 11875–11879. Published online 2000 October 17. PMCID: PMC17262 Geophysics Atmospheric aerosols as prebiotic chemical reactors Christopher M. Dobson, G. Barney Ellison, Adrian F. Tuck, and Veronica Vaida Proc Natl Acad Sci U S A. 2000 October 24; 97(22): 11864–11868. Published online 2000 October 17. PMCID: PMC17260 The magnitude distribution of declustered earthquakes in Southern
California Leon Knopoff Proc Natl Acad Sci U S A. 2000 October 24; 97(22): 11880–11884. Published online 2000 October 17. PMCID: PMC17263 Statistics INAUGURAL ARTICLE by a Recently Elected Academy Member: Bounds for cell entries in contingency tables given marginal
totals and decomposable graphs Adrian Dobra and Stephen E. Fienberg Proc Natl Acad Sci U S A. 2000 October 24; 97(22): 11885–11892. PMCID: PMC17264 Biological Sciences Applied Biological Sciences Cytoplasmic catalytic subunit of protein kinase A mediates
cross-repression by NF-κB and the glucocorticoid receptor Vassilis Doucas, Yanhong Shi, Shigeki Miyamoto, Andrew West, Inder Verma, and Ronald M. Evans Proc Natl Acad Sci U S A. 2000 October 24; 97(22): 11893–11898. Published online 2000 October 10. PMCID: PMC17265 Biochemistry How important are entropic contributions to enzyme
catalysis? J. Villà, M. Štrajbl, T. M. Glennon, Y. Y. Sham, Z. T. Chu, and A. Warshel Proc Natl Acad Sci U S A. 2000 October 24; 97(22): 11899–11904. PMCID: PMC17266 Furin-mediated processing in the early secretory pathway:
Sequential cleavage and degradation of misfolded insulin receptors Joseph Bass, Christopher Turck, Mathias Rouard, and Donald F. Steiner Proc Natl Acad Sci U S A. 2000 October 24; 97(22): 11905–11909. PMCID: PMC17267 A census of glutamine/asparagine-rich regions: Implications for
their conserved function and the prediction of novel prions Melissa D. Michelitsch and Jonathan S. Weissman Proc Natl Acad Sci U S A. 2000 October 24; 97(22): 11910–11915. PMCID: PMC17268 Demonstration of the in vivo interaction of key
cell death regulators by structure-based design of
second-site suppressors Jay Parrish, Helen Metters, Lin Chen, and Ding Xue Proc Natl Acad Sci U S A. 2000 October 24; 97(22): 11916–11921. Published online 2000 October 10. PMCID: PMC17269 Miniaturized metalloproteins: Application to
iron–sulfur proteins Angela Lombardi, Daniela Marasco, Ornella Maglio, Luigi Di Costanzo, Flavia Nastri, and Vincenzo Pavone Proc Natl Acad Sci U S A. 2000 October 24; 97(22): 11922–11927. PMCID: PMC17270 Cytochrome c binding to Apaf-1: The effects of
dATP and ionic strength Cherie Purring-Koch and George McLendon Proc Natl Acad Sci U S A. 2000 October 24; 97(22): 11928–11931. Published online 2000 October 17. PMCID: PMC17271 Molecular basis for modulation of biological function by
alternate splicing of the Wilms' tumor suppressor protein John H. Laity, H. Jane Dyson, and Peter E. Wright Proc Natl Acad Sci U S A. 2000 October 24; 97(22): 11932–11935. PMCID: PMC17272 Phosphorylation of murine p53 at Ser-18 regulates the p53
responses to DNA damage Connie Chao, Shin'ichi Saito, Carl W. Anderson, Ettore Appella, and Yang Xu Proc Natl Acad Sci U S A. 2000 October 24; 97(22): 11936–11941. Published online 2000 October 17. PMCID: PMC17273 Deoxysugars in glycopeptide antibiotics: Enzymatic synthesis of
TDP-l-epivancosamine in chloroeremomycin biosynthesis Huawei Chen, Michael G. Thomas, Brian K. Hubbard, Heather C. Losey, Christopher T. Walsh, and Michael D. Burkart Proc Natl Acad Sci U S A. 2000 October 24; 97(22): 11942–11947. Published online 2000 October 17. PMCID: PMC17274 A single amino acid substitution (F363I) converts the
regiochemistry of the spearmint (−)-limonene
hydroxylase from a C6- to a C3-hydroxylase Michel Schalk and Rodney Croteau Proc Natl Acad Sci U S A. 2000 October 24; 97(22): 11948–11953. PMCID: PMC17275 The complex ATP–Fe2+ serves as a specific affinity
cleavage reagent in ATP-Mg2+ sites of Na,K-ATPase: Altered
ligation of Fe2+ (Mg2+) ions accompanies
the E1P→E2P conformational change Guy Patchornik, Rivka Goldshleger, and Steven J. D. Karlish Proc Natl Acad Sci U S A. 2000 October 24; 97(22): 11954–11959. Published online 2000 October 17. PMCID: PMC17276 Phosphorylation and inactivation of glycogen synthase kinase 3 by
protein kinase A Xianjun Fang, Shuang Xing Yu, Yiling Lu, Robert C. Bast, Jr., James R. Woodgett, and Gordon B. Mills Proc Natl Acad Sci U S A. 2000 October 24; 97(22): 11960–11965. Published online 2000 October 17. PMCID: PMC17277 Polynucleotide phosphorylase functions both as a 3′ → 5′
exonuclease and a poly(A) polymerase in
Escherichia coli Bijoy K. Mohanty and Sidney R. Kushner Proc Natl Acad Sci U S A. 2000 October 24; 97(22): 11966–11971. Published online 2000 October 17. PMCID: PMC17278 Dual roles of the 11S regulatory subcomplex in condensin
functions Keiji Kimura and Tatsuya Hirano Proc Natl Acad Sci U S A. 2000 October 24; 97(22): 11972–11977. Published online 2000 October 10. PMCID: PMC17279 Unique progressive cleavage mechanism of HIV reverse
transcriptase RNase H Michele Wisniewski, Mini Balakrishnan, C. Palaniappan, Philip J. Fay, and Robert A. Bambara Proc Natl Acad Sci U S A. 2000 October 24; 97(22): 11978–11983. Published online 2000 October 17. PMCID: PMC17280 Biochemistry, mutagenesis, and oligomerization of DsRed, a red
fluorescent protein from coral Geoffrey S. Baird, David A. Zacharias, and Roger Y. Tsien Proc Natl Acad Sci U S A. 2000 October 24; 97(22): 11984–11989. PMCID: PMC17281 The structure of the chromophore within DsRed, a red
fluorescent protein from coral Larry A. Gross, Geoffrey S. Baird, Ross C. Hoffman, Kim K. Baldridge, and Roger Y. Tsien Proc Natl Acad Sci U S A. 2000 October 24; 97(22): 11990–11995. PMCID: PMC17282 Biophysics Molecular spectroscopy and dynamics of intrinsically fluorescent
proteins: Coral red (dsRed) and yellow (Citrine) Ahmed A. Heikal, Samuel T. Hess, Geoffrey S. Baird, Roger Y. Tsien, and Watt W. Webb Proc Natl Acad Sci U S A. 2000 October 24; 97(22): 11996–12001. PMCID: PMC17283 Replication by a single DNA polymerase of a stretched
single-stranded DNA Berenike Maier, David Bensimon, and Vincent Croquette Proc Natl Acad Sci U S A. 2000 October 24; 97(22): 12002–12007. PMCID: PMC17284 Mass spectrometry and immobilized enzymes for the screening of
inhibitor libraries Mark T. Cancilla, Michael D. Leavell, Jason Chow, and Julie A. Leary Proc Natl Acad Sci U S A. 2000 October 24; 97(22): 12008–12013. Published online 2000 October 17. PMCID: PMC17285 Nonglassy kinetics in the folding of a simple
single-domain protein Blake Gillespie and Kevin W. Plaxco Proc Natl Acad Sci U S A. 2000 October 24; 97(22): 12014–12019. PMCID: PMC17286 From the Cover: Binding sites in Escherichia coli dihydrofolate
reductase communicate by modulating the conformational ensemble Hong Pan, J. Ching Lee, and Vincent J. Hilser Proc Natl Acad Sci U S A. 2000 October 24; 97(22): 12020–12025. Published online 2000 October 17. PMCID: PMC17287 Negative hair-bundle stiffness betrays a mechanism for mechanical
amplification by the hair cell P. Martin, A. D. Mehta, and A. J. Hudspeth Proc Natl Acad Sci U S A. 2000 October 24; 97(22): 12026–12031. Published online 2000 October 10. PMCID: PMC17288 From the Cover: Allosteric, chiral-selective drug binding to DNA Xiaogang Qu, John O. Trent, Izabela Fokt, Waldemar Priebe, and Jonathan B. Chaires Proc Natl Acad Sci U S A. 2000 October 24; 97(22): 12032–12037. Published online 2000 October 10. PMCID: PMC17289 Anatomy of protein structures: Visualizing how a one-dimensional
protein chain folds into a three-dimensional shape Chung-Jung Tsai, Jacob V. Maizel, Jr., and Ruth Nussinov Proc Natl Acad Sci U S A. 2000 October 24; 97(22): 12038–12043. PMCID: PMC17290 Cell Biology Receptor-mediated endocytosis of soluble and membrane-tethered
Sonic hedgehog by Patched-1 John P. Incardona, Ju Ho Lee, Christie P. Robertson, Kristi Enga, Raj P. Kapur, and Henk Roelink Proc Natl Acad Sci U S A. 2000 October 24; 97(22): 12044–12049. Published online 2000 October 10. PMCID: PMC17291 Peg3/Pw1 promotes p53-mediated apoptosis by inducing
Bax translocation from cytosol to mitochondria Yibin Deng and Xiangwei Wu Proc Natl Acad Sci U S A. 2000 October 24; 97(22): 12050–12055. PMCID: PMC17292 Hematopoietic reconstitution of SLP-76 corrects hemostasis and
platelet signaling through αIIbβ3 and collagen receptors Barbi A. Judd, Peggy S. Myung, Lijun Leng, Achim Obergfell, Warren S. Pear, Sanford J. Shattil, and Gary A. Koretzky Proc Natl Acad Sci U S A. 2000 October 24; 97(22): 12056–12061. PMCID: PMC17293 Creatine kinase, an ATP-generating enzyme, is required for
thrombin receptor signaling to the cytoskeleton Vinit B. Mahajan, Karnire S. Pai, Alice Lau, and Dennis D. Cunningham Proc Natl Acad Sci U S A. 2000 October 24; 97(22): 12062–12067. PMCID: PMC17294 A viral member of the ERV1/ALR protein family participates
in a cytoplasmic pathway of disulfide bond formation Tatiana G. Senkevich, Christine L. White, Eugene V. Koonin, and Bernard Moss Proc Natl Acad Sci U S A. 2000 October 24; 97(22): 12068–12073. Published online 2000 October 17. PMCID: PMC17295 Skeletal muscle deformity and neuronal disorder in Trio exchange
factor-deficient mouse embryos Stephen P. O'Brien, Katja Seipel, Quintus G. Medley, Roderick Bronson, Rosalind Segal, and Michel Streuli Proc Natl Acad Sci U S A. 2000 October 24; 97(22): 12074–12078. PMCID: PMC17296 Coupled two-way clustering analysis of gene microarray data Gad Getz, Erel Levine, and Eytan Domany Proc Natl Acad Sci U S A. 2000 October 24; 97(22): 12079–12084. Published online 2000 October 17. PMCID: PMC17297 Adenomatous polyposis coli protein contains two nuclear export
signals and shuttles between the nucleus and cytoplasm Kristi L. Neufeld, David A. Nix, Hal Bogerd, Yibin Kang, Mary C. Beckerle, Bryan R. Cullen, and Raymond L. White Proc Natl Acad Sci U S A. 2000 October 24; 97(22): 12085–12090. Published online 2000 October 17. PMCID: PMC17298 Phosphorylation-dependent targeting of cAMP response element
binding protein to the ubiquitin/proteasome pathway in hypoxia Cormac T. Taylor, Glenn T. Furuta, Kristin Synnestvedt, and Sean P. Colgan Proc Natl Acad Sci U S A. 2000 October 24; 97(22): 12091–12096. Published online 2000 October 17. PMCID: PMC17299 Control of cellular cholesterol efflux by the nuclear oxysterol
receptor LXRα Asha Venkateswaran, Bryan A. Laffitte, Sean B. Joseph, Puiying A. Mak, Damien C. Wilpitz, Peter A. Edwards, and Peter Tontonoz Proc Natl Acad Sci U S A. 2000 October 24; 97(22): 12097–12102. Published online 2000 October 17. PMCID: PMC17300 Insulin-like growth factor 1 regulates the location, stability,
and transcriptional activity of β-catenin Martin P. Playford, David Bicknell, Walter F. Bodmer, and Valentine M. Macaulay Proc Natl Acad Sci U S A. 2000 October 24; 97(22): 12103–12108. Published online 2000 October 17. PMCID: PMC17301 Direct genetic demonstration of Gα13 coupling to the orphan G
protein-coupled receptor G2A leading to RhoA-dependent
actin rearrangement Janusz H. S. Kabarowski, Jamison D. Feramisco, Lu Q. Le, Jennifer L. Gu, Shiuh-Wen Luoh, Melvin I. Simon, and Owen N. Witte Proc Natl Acad Sci U S A. 2000 October 24; 97(22): 12109–12114. PMCID: PMC17302 Localizing proteins in the cell from their phylogenetic
profiles Edward M. Marcotte, Ioannis Xenarios, Alexander M. van der
Bliek, and David Eisenberg Proc Natl Acad Sci U S A. 2000 October 24; 97(22): 12115–12120. Published online 2000 October 17. PMCID: PMC17303 Developmental Biology Antagonistic role of vega1 and
bozozok/dharma homeobox genes in organizer formation Atsuo Kawahara, Thomas Wilm, Lilianna Solnica-Krezel, and Igor B. Dawid Proc Natl Acad Sci U S A. 2000 October 24; 97(22): 12121–12126. PMCID: PMC17304 Parameters of self-organization in
Hydra aggregates Ulrich Technau, Christoph Cramer von Laue, Fabian Rentzsch, Susanne Luft, Bert Hobmayer, Hans R. Bode, and Thomas W. Holstein Proc Natl Acad Sci U S A. 2000 October 24; 97(22): 12127–12131. PMCID: PMC17305 Clonogenic hepatoblasts, common precursors for hepatocytic and
biliary lineages, are lacking classical major histocompatibility
complex class I antigen Hiroshi Kubota and Lola M. Reid Proc Natl Acad Sci U S A. 2000 October 24; 97(22): 12132–12137. PMCID: PMC17306 Quantitative transcript imaging in normal and heat-shocked
Drosophila embryos by using high-density
oligonucleotide arrays Ronny Leemans, Boris Egger, Thomas Loop, Lars Kammermeier, Haiqiong He, Beate Hartmann, Ulrich Certa, Frank Hirth, and Heinrich Reichert Proc Natl Acad Sci U S A. 2000 October 24; 97(22): 12138–12143. Published online 2000 October 17. PMCID: PMC17307 Ecology From the Cover: Ecological basis of extinction risk in birds: Habitat loss versus
human persecution and introduced predators Ian P. F. Owens and Peter M. Bennett Proc Natl Acad Sci U S A. 2000 October 24; 97(22): 12144–12148. Published online 2000 September 26. PMCID: PMC17308 Evolution Social enhancement of fitness in yellow-bellied marmots Kenneth B. Armitage and Orlando A. Schwartz Proc Natl Acad Sci U S A. 2000 October 24; 97(22): 12149–12152. Published online 2000 October 17. PMCID: PMC17309 Origin of mitochondria in relation to evolutionary history of
eukaryotic alanyl-tRNA synthetase Joseph W. Chihade, James R. Brown, Paul R. Schimmel, and Lluís Ribas de Pouplana Proc Natl Acad Sci U S A. 2000 October 24; 97(22): 12153–12157. Published online 2000 October 17. PMCID: PMC17310 Genetics Coupled two-way clustering analysis of gene microarray data Gad Getz, Erel Levine, and Eytan Domany Proc Natl Acad Sci U S A. 2000 October 24; 97(22): 12079–12084. Published online 2000 October 17. PMCID: PMC17297 A Saccharomyces gene family involved in invasive
growth, cell–cell adhesion, and mating Bing Guo, Cora A. Styles, Qinghua Feng, and Gerald R. Fink Proc Natl Acad Sci U S A. 2000 October 24; 97(22): 12158–12163. Published online 2000 October 10. PMCID: PMC17311 SBE-TAGS: An array-based method for efficient single-nucleotide
polymorphism genotyping Joel N. Hirschhorn, Pamela Sklar, Kerstin Lindblad-Toh, Yin-Mei Lim, Melisa Ruiz-Gutierrez, Stacey Bolk, Bradley Langhorst, Steven Schaffner, Ellen Winchester, and Eric S. Lander Proc Natl Acad Sci U S A. 2000 October 24; 97(22): 12164–12169. Published online 2000 October 17. PMCID: PMC17312 DNA microarray analysis of gene expression in response to
physiological and genetic changes that affect tryptophan metabolism
in Escherichia coli Arkady B. Khodursky, Brian J. Peter, Nicholas R. Cozzarelli, David Botstein, Patrick O. Brown, and Charles Yanofsky Proc Natl Acad Sci U S A. 2000 October 24; 97(22): 12170–12175. Published online 2000 October 10. PMCID: PMC17313 From the Cover: Genome sequence of Halobacterium species NRC-1 Wailap Victor Ng, Sean P. Kennedy, Gregory G. Mahairas, Brian Berquist, Min Pan, Hem Dutt Shukla, Stephen R. Lasky, Nitin S. Baliga, Vesteinn Thorsson, Jennifer Sbrogna, Steven Swartzell, Douglas Weir, John Hall, Timothy A. Dahl, Russell Welti, Young Ah Goo, Brent Leithauser, Kim Keller, Randy Cruz, Michael J. Danson, David W. Hough, Deborah G. Maddocks, Peter E. Jablonski, Mark P. Krebs, Christine M. Angevine, Heather Dale, Thomas A. Isenbarger, Ronald F. Peck, Mechthild Pohlschroder, John L. Spudich, Kwang-Hwan Jung, Maqsudul Alam, Tracey Freitas, Shaobin Hou, Charles J. Daniels, Patrick P. Dennis, Arina D. Omer, Holger Ebhardt, Todd M. Lowe, Ping Liang, Monica Riley, Leroy Hood, and Shiladitya DasSarma Proc Natl Acad Sci U S A. 2000 October 24; 97(22): 12176–12181. Published online 2000 October 3. PMCID: PMC17314 Discovering functional relationships between RNA expression and
chemotherapeutic susceptibility using relevance networks Atul J. Butte, Pablo Tamayo, Donna Slonim, Todd R. Golub, and Isaac S. Kohane Proc Natl Acad Sci U S A. 2000 October 24; 97(22): 12182–12186. Published online 2000 October 10. PMCID: PMC17315 The pachytene checkpoint prevents accumulation and
phosphorylation of the meiosis-specific transcription factor Ndt80 Kuei-Shu Tung, Eun-Jin
Erica Hong, and G. Shirleen Roeder Proc Natl Acad Sci U S A. 2000 October 24; 97(22): 12187–12192. Published online 2000 October 17. PMCID: PMC17316 Immunology X-ray crystal structure of an anti-Buckminsterfullerene antibody
Fab fragment: Biomolecular recognition of C60 Bradford C. Braden, Fernando A. Goldbaum, Bi-Xing Chen, Austin N. Kirschner, Stephen R. Wilson, and Bernard F. Erlanger Proc Natl Acad Sci U S A. 2000 October 24; 97(22): 12193–12197. Published online 2000 October 17. PMCID: PMC17317 Induction of primary NY-ESO-1 immunity: CD8+ T lymphocyte and
antibody responses in peptide-vaccinated patients with NY-ESO-1+ cancers Elke Jäger, Sacha Gnjatic, Yasuhiro Nagata, Elisabeth Stockert, Dirk Jäger, Julia Karbach, Antje Neumann, Julia Rieckenberg, Yao-Tseng Chen, Gerd Ritter, Eric Hoffman, Michael Arand, Lloyd J. Old, and Alexander Knuth Proc Natl Acad Sci U S A. 2000 October 24; 97(22): 12198–12203. Published online 2000 October 10. PMCID: PMC17318 Pinpointing when T cell costimulatory receptor CTLA-4 must be
engaged to dampen diabetogenic T cells Fred Lühder, Cynthia Chambers, James P. Allison, Christophe Benoist, and Diane Mathis Proc Natl Acad Sci U S A. 2000 October 24; 97(22): 12204–12209. Published online 2000 October 17. PMCID: PMC17319 Antimicrobial activity of MHC class I-restricted CD8+ T cells in
human tuberculosis Sungae Cho, Vijay Mehra, Sybille Thoma-Uszynski, Steffen Stenger, Natalya Serbina, Richard J. Mazzaccaro, JoAnne L. Flynn, Peter F. Barnes, Scott Southwood, Esteban Celis, Barry R. Bloom, Robert L. Modlin, and Alessandro Sette Proc Natl Acad Sci U S A. 2000 October 24; 97(22): 12210–12215. Published online 2000 October 17. PMCID: PMC17320 Medical Sciences PCGEM1, a prostate-specific gene, is overexpressed
in prostate cancer Vasantha Srikantan, Zhiqiang Zou, Gyorgy Petrovics, Linda Xu, Meena Augustus, Leland Davis, Jeffrey R. Livezey, Theresa Connell, Isabell A. Sesterhenn, Kiyoshi Yoshino, Gregory S. Buzard, F. K. Mostofi, David G. McLeod, Judd W. Moul, and Shiv Srivastava Proc Natl Acad Sci U S A. 2000 October 24; 97(22): 12216–12221. PMCID: PMC17321 Hyperglycemia-induced mitochondrial superoxide overproduction
activates the hexosamine pathway and induces plasminogen activator
inhibitor-1 expression by increasing Sp1 glycosylation Xue-Liang Du, Diane Edelstein, Luciano Rossetti, Ivan George Fantus, Howard Goldberg, Fuad Ziyadeh, Jie Wu, and Michael Brownlee Proc Natl Acad Sci U S A. 2000 October 24; 97(22): 12222–12226. PMCID: PMC17322 Suppression of angiogenesis by lentiviral delivery of PEX, a
noncatalytic fragment of matrix metalloproteinase 2 Alexander Pfeifer, Torsten Kessler, Steve Silletti, David A. Cheresh, and Inder M. Verma Proc Natl Acad Sci U S A. 2000 October 24; 97(22): 12227–12232. Published online 2000 October 17. PMCID: PMC17323 BCR/ABL inhibition by an escort/phosphatase fusion protein Young-Mi Lim, Stephane Wong, Gary Lau, Owen N. Witte, and John Colicelli Proc Natl Acad Sci U S A. 2000 October 24; 97(22): 12233–12238. Published online 2000 October 10. PMCID: PMC17324 Frataxin activates mitochondrial energy conversion and
oxidative phosphorylation Michael Ristow, Markus F. Pfister, Andrew J. Yee, Markus Schubert, Laura Michael, Chen-Yu Zhang, Kojhiro Ueki, M. Dodson Michael, II, Bradford B. Lowell, and C. Ronald Kahn Proc Natl Acad Sci U S A. 2000 October 24; 97(22): 12239–12243. Published online 2000 October 17. PMCID: PMC17325 Human lung cancer and p53: The interplay between
mutagenesis and selection Sergei N. Rodin and Andrew S. Rodin Proc Natl Acad Sci U S A. 2000 October 24; 97(22): 12244–12249. Published online 2000 October 17. PMCID: PMC17326 Tonsillar memory B cells, latently infected with Epstein–Barr
virus, express the restricted pattern of latent genes previously
found only in Epstein–Barr virus-associated tumors Gregory J. Babcock and David A. Thorley-Lawson Proc Natl Acad Sci U S A. 2000 October 24; 97(22): 12250–12255. Published online 2000 October 17. PMCID: PMC17327 Prostate formation in a marsupial is mediated by the testicular
androgen 5α-androstane-3α,17β-diol Geoffrey Shaw, Marilyn B. Renfree, Michael W. Leihy, Cedric H. L. Shackleton, Esther Roitman, and Jean D. Wilson Proc Natl Acad Sci U S A. 2000 October 24; 97(22): 12256–12259. Published online 2000 October 17. PMCID: PMC17328 Hematopoietic progenitor cells grow on 3T3 fibroblast monolayers
that overexpress growth arrest-specific gene-6 (GAS6) Shane P. Dormady, Xin-Min Zhang, and Ross S. Basch Proc Natl Acad Sci U S A. 2000 October 24; 97(22): 12260–12265. PMCID: PMC17329 Intracellular antibody-caspase-mediated cell killing: An approach
for application in cancer therapy Eric Tse and Terence H. Rabbitts Proc Natl Acad Sci U S A. 2000 October 24; 97(22): 12266–12271. PMCID: PMC17330 Regulation of T cell activation, anxiety, and male aggression
by RGS2 Antonio J. Oliveira-dos-Santos, Goichi Matsumoto, Bryan E. Snow, Donglin Bai, Frank P. Houston, Ian Q. Whishaw, Sanjeev Mariathasan, Takehiko Sasaki, Andrew Wakeham, Pamela S. Ohashi, John C. Roder, Carol A. Barnes, David P. Siderovski, and Josef M. Penninger Proc Natl Acad Sci U S A. 2000 October 24; 97(22): 12272–12277. Published online 2000 October 10. PMCID: PMC17331 Visualizing gene expression by whole-body fluorescence imaging Meng Yang, Eugene Baranov, A. R. Moossa, Sheldon Penman, and Robert M. Hoffman Proc Natl Acad Sci U S A. 2000 October 24; 97(22): 12278–12282. PMCID: PMC17332 Microbiology A viral member of the ERV1/ALR protein family participates
in a cytoplasmic pathway of disulfide bond formation Tatiana G. Senkevich, Christine L. White, Eugene V. Koonin, and Bernard Moss Proc Natl Acad Sci U S A. 2000 October 24; 97(22): 12068–12073. Published online 2000 October 17. PMCID: PMC17295 A secreted Salmonella protein induces a
proinflammatory response in epithelial cells, which promotes
neutrophil migration Catherine A. Lee, Milton Silva, Andrew M. Siber, Aaron J. Kelly, Edouard Galyov, and Beth A. McCormick Proc Natl Acad Sci U S A. 2000 October 24; 97(22): 12283–12288. PMCID: PMC17333 The Ebola virus VP35 protein functions as a type I
IFN antagonist Christopher F. Basler, Xiuyan Wang, Elke Mühlberger, Victor Volchkov, Jason Paragas, Hans-Dieter Klenk, Adolfo García-Sastre, and Peter Palese Proc Natl Acad Sci U S A. 2000 October 24; 97(22): 12289–12294. Published online 2000 October 10. PMCID: PMC17334 A conserved mechanism of retrovirus restriction in mammals Greg Towers, Michael Bock, Samia Martin, Yasuhiro Takeuchi, Jonathan P. Stoye, and Olivier Danos Proc Natl Acad Sci U S A. 2000 October 24; 97(22): 12295–12299. Published online 2000 October 10. PMCID: PMC17335 Neurobiology Neuromelanin biosynthesis is driven by excess cytosolic
catecholamines not accumulated by synaptic vesicles David Sulzer, Johanna Bogulavsky, Kristin E. Larsen, Gerald Behr, Erdem Karatekin, Mark H. Kleinman, Nicholas Turro, David Krantz, Robert H. Edwards, Lloyd A. Greene, and Luigi Zecca Proc Natl Acad Sci U S A. 2000 October 24; 97(22): 11869–11874. PMCID: PMC17261 Functional switching of GABAergic synapses by ryanodine
receptor activation Miao-Kun Sun, Thomas J. Nelson, and Daniel L. Alkon Proc Natl Acad Sci U S A. 2000 October 24; 97(22): 12300–12305. Published online 2000 October 10. PMCID: PMC17336 Reduction of axonal caliber does not alleviate motor neuron
disease caused by mutant superoxide dismutase 1 Minh Dang Nguyen, Roxanne C. Larivière, and Jean-Pierre Julien Proc Natl Acad Sci U S A. 2000 October 24; 97(22): 12306–12311. PMCID: PMC17337 Development and persistence of kindling epilepsy are impaired in
mice lacking glial cell line-derived neurotrophic factor family
receptor α2 Avtandil Nanobashvili, Matti S. Airaksinen, Merab Kokaia, Jari Rossi, Fredrik Asztély, Klara Olofsdotter, Paul Mohapel, Mart Saarma, Olle Lindvall, and Zaal Kokaia Proc Natl Acad Sci U S A. 2000 October 24; 97(22): 12312–12317. PMCID: PMC17338 Constitutive expression of the neuron-restrictive silencer factor
(NRSF)/REST in differentiating neurons disrupts neuronal gene
expression and causes axon pathfinding errors in
vivo Alice J. Paquette, Sharon E. Perez, and David J. Anderson Proc Natl Acad Sci U S A. 2000 October 24; 97(22): 12318–12323. PMCID: PMC17339 Photoperiodic information acquired and stored in
vivo is retained in vitro by a circadian
oscillator, the avian pineal gland Roland Brandstätter, Vinod Kumar, Ute Abraham, and Eberhard Gwinner Proc Natl Acad Sci U S A. 2000 October 24; 97(22): 12324–12328. Published online 2000 September 26. PMCID: PMC17340 Pharmacology A structural basis for drug-induced long QT syndrome John S. Mitcheson, Jun Chen, Monica Lin, Chris Culberson, and Michael C. Sanguinetti Proc Natl Acad Sci U S A. 2000 October 24; 97(22): 12329–12333. Published online 2000 September 26. PMCID: PMC17341 Physiology Inhibition of cardiac L-type calcium channels by protein kinase C
phosphorylation of two sites in the N-terminal domain Damian McHugh, Elizabeth M. Sharp, Todd Scheuer, and William A. Catterall Proc Natl Acad Sci U S A. 2000 October 24; 97(22): 12334–12338. Published online 2000 October 17. PMCID: PMC17342 A metabolic defect promotes obesity in mice lacking
melanocortin-4 receptors Linda Ste. Marie, Grant I. Miura, Donald J. Marsh, Keith Yagaloff, and Richard D. Palmiter Proc Natl Acad Sci U S A. 2000 October 24; 97(22): 12339–12344. Published online 2000 October 10. PMCID: PMC17343 Plant Biology Role of microtubules in the intracellular distribution of tobacco
mosaic virus movement protein Paloma Más and Roger N. Beachy Proc Natl Acad Sci U S A. 2000 October 24; 97(22): 12345–12349. PMCID: PMC17344 Substrate-dependent mutant complementation to select fatty acid
desaturase variants for metabolic engineering of plant seed oils Edgar B. Cahoon and John Shanklin Proc Natl Acad Sci U S A. 2000 October 24; 97(22): 12350–12355. Published online 2000 October 10. PMCID: PMC17345 Altered selectivity in an Arabidopsis
metal transporter Elizabeth E. Rogers, David J. Eide, and Mary Lou Guerinot Proc Natl Acad Sci U S A. 2000 October 24; 97(22): 12356–12360. Published online 2000 October 17. PMCID: PMC17346 INAUGURAL ARTICLE by a Recently Elected Academy Member: ABA activates multiple Ca 2+ fluxes in stomatal guard
cells, triggering vacuolar K +(Rb +) release Enid A. C. MacRobbie Proc Natl Acad Sci U S A. 2000 October 24; 97(22): 12361–12368. Published online 2000 October 10. PMCID: PMC17347 Population Biology Manifold anomalies in gene expression in a vineyard isolate of
Saccharomyces cerevisiae revealed by DNA microarray
analysis Duccio Cavalieri, Jeffrey P. Townsend, and Daniel L. Hartl Proc Natl Acad Sci U S A. 2000 October 24; 97(22): 12369–12374. Published online 2000 October 17. PMCID: PMC17348 Psychology The visual paired-comparison task as a measure of
declarative memory Joseph R. Manns, Craig E. L. Stark, and Larry R. Squire Proc Natl Acad Sci U S A. 2000 October 24; 97(22): 12375–12379. Published online 2000 October 10. PMCID: PMC17349 Failure to handle more than one internal representation in visual
detection tasks Andrei Gorea and Dov Sagi Proc Natl Acad Sci U S A. 2000 October 24; 97(22): 12380–12384. PMCID: PMC17350 Social Sciences Social Sciences From the Cover: Prostitution and the sex discrepancy in reported number of
sexual partners Devon D. Brewer, John J. Potterat, Sharon B. Garrett, Stephen Q. Muth, John M. Roberts, Jr., Danuta Kasprzyk, Daniel E. Montano, and William W. Darrow Proc Natl Acad Sci U S A. 2000 October 24; 97(22): 12385–12388. Published online 2000 October 10. PMCID: PMC17351 |