Variation and evolution in plants and microorganisms: Toward a new synthesis 50 years after Stebbins

G. Ledyard Stebbins (1906–2000): An appreciation

Solution to Darwin's dilemma: Discovery of the missing Precambrian record of life

The chimeric eukaryote: Origin of the nucleus from the karyomastigont in amitochondriate protists

Dynamic evolution of plant mitochondrial genomes: Mobile genes and introns and highly variable mutation rates

The evolution of RNA viruses: A population genetics view

Effects of passage history and sampling bias on phylogenetic reconstruction of human influenza A evolution

Bacteria are different: Observations, interpretations, speculations, and opinions about the mechanisms of adaptive evolution in prokaryotes

Evolution of RNA editing in trypanosome mitochondria

Population structure and recent evolution of Plasmodium falciparum

Transposons and genome evolution in plants

Maize as a model for the evolution of plant nuclear genomes

Flower color variation: A model for the experimental study of evolution

Gene genealogies and population variation in plants

Toward a new synthesis: Major evolutionary trends in the angiosperm fossil record

Reproductive systems and evolution in vascular plants

Hybridization as a stimulus for the evolution of invasiveness in plants?

The role of genetic and genomic attributes in the success of polyploids

A confederacy of bunches: Fundamentals and applications of a self-associating protein

Genome, diversity, and origins: The Y chromosome as a storyteller

Atherosclerosis: The emerging role of inflammation and the CD40–CD40 ligand system

Natural T cells: Cranking up the immune system by prompt cytokine secretion

Gelsolin and ADF/cofilin enhance the actin dynamics of motile cells

Protection of auditory receptors and neurons: Evidence for interactive damage

True optical resolution beyond the Rayleigh limit achieved by standing wave illumination

Toward antibody-catalyzed hydrolysis of organophosphorus poisons

Size exclusion chromatography does not require pores

The asymptotic distribution of canonical correlations and variates in cointegrated models

Museum specimen data predict crop damage by tropical rodents

Suppressed T helper 2 immunity and prolonged survival of a nematode parasite in protein-malnourished mice

Long-range order in the src SH3 folding transition state

Pausing by bacterial RNA polymerase is mediated by mechanistically distinct classes of signals

A ligand-reversible dimerization system for controlling protein–protein interactions

Osmoregulated ABC-transport system of Lactococcus lactis senses water stress via changes in the physical state of the membrane

Structural hierarchy in erythrocruorin, the giant respiratory assemblage of annelids

Recombinant tobacco mosaic virus movement protein is an RNA-binding, α-helical membrane protein

Regulation of oxidative stress-induced calcium release by phosphatidylinositol 3-kinase and Bruton's tyrosine kinase in B cells

Structure-based discovery of an organic compound that binds Bcl-2 protein and induces apoptosis of tumor cells

A second calcineurin binding site on the NFAT regulatory domain

A modular chitin-binding protease associated with hemocytes and hemolymph in the mosquito Anopheles gambiae

Replication-induced transcription of an autorepressed gene: The replication initiator gene of plasmid P1

Stochastic focusing: Fluctuation-enhanced sensitivity of intracellular regulation

Biosynthesis of a major lipofuscin fluorophore in mice and humans with ABCR-mediated retinal and macular degeneration

Differential ligand-dependent protein–protein interactions between nuclear receptors and a neuronal-specific cofactor

Regulation of the homeodomain CCAAT displacement/cut protein function by histone acetyltransferases p300/CREB-binding protein (CBP)-associated factor and CBP

A downstream element in the human β-globin promoter: Evidence of extended sequence-specific transcription factor IID contacts

A role of transcriptional activators as antirepressors for the autoinhibitory activity of TATA box binding of transcription factor IID

The C-terminal domain-phosphorylated IIO form of RNA polymerase II is associated with the transcription repressor NC2 (Dr1/DRAP1) and is required for transcription activation in human nuclear extracts

Adenosylcobalamin inhibits ribosome binding to btuB RNA

Characterization of bacteriophage T4-coordinated leading- and lagging-strand synthesis on a minicircle substrate

The histone deacetylase-3 complex contains nuclear receptor corepressors

Selenium-dependent metabolism of purines: A selenium-dependent purine hydroxylase and xanthine dehydrogenase were purified from Clostridium purinolyticum and characterized

Homologs of the yeast Sec complex subunits Sec62p and Sec63p are abundant proteins in dog pancreas microsomes

Measuring the rate of intramolecular contact formation in polypeptides

True optical resolution beyond the Rayleigh limit achieved by standing wave illumination

Real-time light-driven dynamics of the fluorescence emission in single green fluorescent protein molecules

Stepping rotation of F₁-ATPase visualized through angle-resolved single-fluorophore imaging

DNA delivery by phage as a strategy for encapsulating toroidal condensates of arbitrary size into liposomes

Native topology determines force-induced unfolding pathways in globular proteins

Chimeric green fluorescent protein-aequorin as bioluminescent Ca²⁺ reporters at the single-cell level

Human centromere protein A (CENP-A) can replace histone H3 in nucleosome reconstitution in vitro

MEK kinase 1 gene disruption alters cell migration and c-Jun NH₂-terminal kinase regulation but does not cause a measurable defect in NF-κB activation

Interferon regulatory factor subcellular localization is determined by a bipartite nuclear localization signal in the DNA-binding domain and interaction with cytoplasmic retention factors

huASH1 protein, a putative transcription factor encoded by a human homologue of the Drosophila ash1 gene, localizes to both nuclei and cell–cell tight junctions

v-Crk activates the phosphoinositide 3-kinase/AKT pathway in transformation

Parathyroid hormone-related protein induces spontaneous osteoclast formation via a paracrine cascade

Identification and characterization of a p53 homologue in Drosophila melanogaster

Inhibition of sonic hedgehog autoprocessing in cultured mammalian cells by sterol deprivation

GLUT8 is a glucose transporter responsible for insulin-stimulated glucose uptake in the blastocyst

Crosstalk pathway for inhibition of glucocorticoid-induced apoptosis by T cell receptor signaling

A complex of iron and nucleic acid catabolites is a signal that triggers differentiation in a freshwater protozoan

DER signaling restricts the boundaries of the wing field during Drosophila development

Circadian rise in maternal glucocorticoid prevents pulmonary dysplasia in fetal mice with adrenal insufficiency

Isolation and characterization of BEN, a member of the TFII-I family of DNA-binding proteins containing distinct helix–loop–helix domains

The multitype zinc-finger protein U-shaped functions in heart cell specification in the Drosophila embryo

Population genetic implications from sequence variation in four Y chromosome genes

Recent common ancestry of human Y chromosomes: Evidence from DNA sequence data

Ultraviolet pigments in birds evolved from violet pigments by a single amino acid change

Derivation of the relationship between neutral mutation and fixation solely from the definition of selective neutrality

Transposon diversity in Arabidopsis thaliana

A bacterial two-hybrid selection system for studying protein–DNA and protein–protein interactions

Precise gene localization by phenotypic assay of radiation hybrid cells

Transposon stability and a role for conjugational transfer in adaptive mutability

The RecD subunit of the Escherichia coli RecBCD enzyme inhibits RecA loading, homologous recombination, and DNA repair

Chromosome instability contributes to loss of heterozygosity in mice lacking p53

Multiple differences in gene expression in regulatory Vα24JαQ T cells from identical twins discordant for type I diabetes

Do lampreys have lymphocytes? The Spi evidence

Regulation of protein kinase CβI by two protein-tyrosine kinases, Btk and Syk

Different sensitivity to receptor editing of B cells from mice hemizygous or homozygous for targeted Ig transgenes

B cell receptor expression level determines the fate of developing B lymphocytes: Receptor editing versus selection

G protein-coupled receptor kinase-5 regulates thrombin-activated signaling in endothelial cells

T cell immunity to copolymer 1 confers neuroprotection on the damaged optic nerve: Possible therapy for optic neuropathies

Multiple sclerosis: Comparison of copolymer-1- reactive T cell lines from treated and untreated subjects reveals cytokine shift from T helper 1 to T helper 2 cells

Inhibition of CD40 signaling limits evolution of established atherosclerosis in mice

Both early and delayed anti-CD40L antibody treatment induces a stable plaque phenotype

The X-linked lymphoproliferative syndrome gene product SH2D1A associates with p62^dok (Dok1) and activates NF-κB

Multidrug-resistance protein 5 is a multispecific organic anion transporter able to transport nucleotide analogs

Peripheral infection with adenovirus causes unexpected long-term brain inflammation in animals injected intracranially with first-generation, but not with high-capacity, adenovirus vectors: Toward realistic long-term neurological gene therapy for chronic diseases

A macrophage receptor for apolipoprotein B48: Cloning, expression, and atherosclerosis

Tumor selective G₂/M cell cycle arrest and apoptosis of epithelial and hematological malignancies by BBL22, a benzazepine

St. John's wort induces hepatic drug metabolism through activation of the pregnane X receptor

Unarmed, tumor-specific monoclonal antibody effectively treats brain tumors

Targeted disruption of an erythrocyte binding antigen in Plasmodium falciparum is associated with a switch toward a sialic acid-independent pathway of invasion

Long-term enzyme correction and lipid reduction in multiple organs of primary and secondary transplanted Fabry mice receiving transduced bone marrow cells

AML1/ETO-expressing nonleukemic stem cells in acute myelogenous leukemia with 8;21 chromosomal translocation

Minimal exclusion of plasma membrane proteins during retroviral envelope formation

A M_r 34,000 proinflammatory outer membrane protein (oipA) of Helicobacter pylori

A conserved amino acid sequence directing intracellular type III secretion by Salmonella typhimurium

Transferred DNA (T-DNA)-associated proteins of Agrobacterium tumefaciens are exported independently of virB

Steroid receptor coactivator-1 (SRC-1) mediates the development of sex-specific brain morphology and behavior

The role of spatiotemporal edges in visibility and visual masking

Antiapoptotic role of the p38 mitogen-activated protein kinase–myocyte enhancer factor 2 transcription factor pathway during neuronal differentiation

Noninvasive gene targeting to the brain

Immunogold evidence that neuronal gap junctions in adult rat brain and spinal cord contain connexin-36 but not connexin-32 or connexin-43

Opiates inhibit neurogenesis in the adult rat hippocampus

Negative regulation of central nervous system myelination by polysialylated-neural cell adhesion molecule

Attentional modulation of effective connectivity from V2 to V5/MT in humans

Coupling between changes in human brain temperature and oxidative metabolism during prolonged visual stimulation

In vivo detection of amyloid plaques in a mouse model of Alzheimer's disease

Systematic identification of mutations that constitutively activate the angiotensin II type 1A receptor by screening a randomly mutated cDNA library with an original pharmacological bioassay

A substance P-opioid chimeric peptide as a unique nontolerance-forming analgesic

T-type α1H Ca²⁺ channels are involved in Ca²⁺ signaling during terminal differentiation (fusion) of human myoblasts

Cloning of the Arabidopsis WIGGUM gene identifies a role for farnesylation in meristem development

Pectin engineering: Modification of potato pectin by in vivo expression of an endo-1,4-β-d-galactanase

Gamma and beta frequency oscillations in response to novel auditory stimuli: A comparison of human electroencephalogram (EEG) data with in vitro models

Dissociating the role of the medial and lateral anterior prefrontal cortex in human planning

Enhanced learning after genetic overexpression of a brain growth protein

The asymptotic distribution of canonical correlations and variates in cointegrated models