| | This journal provides immediate access to some articles. Editorial PNAS at volume 100 Nicholas R. Cozzarelli Proc Natl Acad Sci U S A. 2003 March 18; 100(6): 3005–3006. doi: 10.1073/pnas.0730842100.PMCID: PMC152229 Commentaries The dynamic spore Adam Driks Proc Natl Acad Sci U S A. 2003 March 18; 100(6): 3007–3009. Published online 2003 March 11. doi: 10.1073/pnas.0730807100.PMCID: PMC152230 Polyketide and non-ribosomal peptide synthases: Falling together by coming apart C. Richard Hutchinson Proc Natl Acad Sci U S A. 2003 March 18; 100(6): 3010–3012. Published online 2003 March 11. doi: 10.1073/pnas.0730689100.PMCID: PMC152231 Ozone in biology Richard A. Lerner and Albert Eschenmoser Proc Natl Acad Sci U S A. 2003 March 18; 100(6): 3013–3015. Published online 2003 March 11. doi: 10.1073/pnas.0730791100.PMCID: PMC152232 Component processes underlying choice John T. Cacioppo and Howard S. Nusbaum Proc Natl Acad Sci U S A. 2003 March 18; 100(6): 3016–3017. Published online 2003 March 11. doi: 10.1073/pnas.0730744100.PMCID: PMC152233 Diarrhea or colorectal cancer: Can bacterial toxins serve as a treatment for colon cancer? S. L. Carrithers Proc Natl Acad Sci U S A. 2003 March 18; 100(6): 3018–3020. Published online 2003 March 11. doi: 10.1073/pnas.0730484100.PMCID: PMC152234 Perspective Revisiting the independence of the publicly and privately funded drafts of the human genome Nicholas R. Cozzarelli Proc Natl Acad Sci U S A. 2003 March 18; 100(6): 3021. Published online 2003 March 11. doi: 10.1073/pnas.0830968100.PMCID: PMC152235 More on the sequencing of the human genome Robert H. Waterston, Eric S. Lander, and John E. Sulston Proc Natl Acad Sci U S A. 2003 March 18; 100(6): 3022–3024. Published online 2003 March 11. doi: 10.1073/pnas.0634129100.PMCID: PMC152236 The independence of our genome assemblies Mark D. Adams, Granger G. Sutton, Hamilton O. Smith, Eugene W. Myers, and J. Craig Venter Proc Natl Acad Sci U S A. 2003 March 18; 100(6): 3025–3026. Published online 2003 March 11. doi: 10.1073/pnas.0637478100.PMCID: PMC152237 Type III secretion systems and bacterial flagella: Insights into their function from structural similarities Ariel Blocker, Kaoru Komoriya, and Shin-Ichi Aizawa Proc Natl Acad Sci U S A. 2003 March 18; 100(6): 3027–3030. Published online 2003 March 11. doi: 10.1073/pnas.0535335100.PMCID: PMC152238 Physical Sciences Chemistry From the Cover: Investigating antibody-catalyzed ozone generation by human neutrophils Bernard M. Babior, Cindy Takeuchi, Julie Ruedi, Abel Gutierrez, and Paul Wentworth, Jr. Proc Natl Acad Sci U S A. 2003 March 18; 100(6): 3031–3034. Published online 2003 February 24. doi: 10.1073/pnas.0530251100.PMCID: PMC152239 Is the olfactory receptor a metalloprotein? Jiangyun Wang, Zaida A. Luthey-Schulten, and Kenneth S. Suslick Proc Natl Acad Sci U S A. 2003 March 18; 100(6): 3035–3039. Published online 2003 February 27. doi: 10.1073/pnas.262792899.PMCID: PMC152240 Chiral tubule self-assembly from an achiral diynoic lipid Serhii Pakhomov, Robert P. Hammer, Bijaya K. Mishra, and Britt N. Thomas Proc Natl Acad Sci U S A. 2003 March 18; 100(6): 3040–3042. Published online 2003 March 7. doi: 10.1073/pnas.0030051100.PMCID: PMC152241 Discrete two-terminal single nanocluster quantum optoelectronic logic operations at room temperature Tae-Hee Lee and Robert M. Dickson Proc Natl Acad Sci U S A. 2003 March 18; 100(6): 3043–3046. Published online 2003 March 5. doi: 10.1073/pnas.0635474100.PMCID: PMC152242 Watching proteins fold one molecule at a time Elizabeth Rhoades, Eugene Gussakovsky, and Gilad Haran Proc Natl Acad Sci U S A. 2003 March 18; 100(6): 3197–3202. Published online 2003 February 28. doi: 10.1073/pnas.2628068100.PMCID: PMC152269 Geophysics Nuclear georeactor origin of oceanic basalt 3He/4He, evidence, and implications J. Marvin Herndon Proc Natl Acad Sci U S A. 2003 March 18; 100(6): 3047–3050. Published online 2003 March 3. doi: 10.1073/pnas.0437778100.PMCID: PMC152243 Physics Discrete two-terminal single nanocluster quantum optoelectronic logic operations at room temperature Tae-Hee Lee and Robert M. Dickson Proc Natl Acad Sci U S A. 2003 March 18; 100(6): 3043–3046. Published online 2003 March 5. doi: 10.1073/pnas.0635474100.PMCID: PMC152242 Liquid–liquid phase transition in compressed hydrogen from first-principles simulations Sandro Scandolo Proc Natl Acad Sci U S A. 2003 March 18; 100(6): 3051–3053. Published online 2003 March 7. doi: 10.1073/pnas.0038012100.PMCID: PMC152244 INAUGURAL ARTICLE by a Recently Elected Academy Member: Extending the definition of entropy to nonequilibrium steady states David P. Ruelle Proc Natl Acad Sci U S A. 2003 March 18; 100(6): 3054–3058. Published online 2003 March 10. doi: 10.1073/pnas.0630567100.PMCID: PMC152245 Biological Sciences Applied Biological Sciences A high-throughput gene expression analysis technique using competitive PCR and matrix-assisted laser desorption ionization time-of-flight MS Chunming Ding and Charles R. Cantor Proc Natl Acad Sci U S A. 2003 March 18; 100(6): 3059–3064. Published online 2003 March 6. doi: 10.1073/pnas.0630494100.PMCID: PMC152246 From the Cover: Functional proteomics of nonalcoholic steatohepatitis: Mitochondrial proteins as targets of S-adenosylmethionine Enrique Santamaría, Matías A. Avila, M. Ujue Latasa, Angel Rubio, Antonio Martín-Duce, Shelly C. Lu, José M. Mato, and Fernando J. Corrales Proc Natl Acad Sci U S A. 2003 March 18; 100(6): 3065–3070. Published online 2003 March 11. doi: 10.1073/pnas.0536625100.PMCID: PMC152247 Computational and experimental analysis of DNA shuffling Narendra Maheshri and David V. Schaffer Proc Natl Acad Sci U S A. 2003 March 18; 100(6): 3071–3076. Published online 2003 March 7. doi: 10.1073/pnas.0537968100.PMCID: PMC152248 Biochemistry From the Cover: Investigating antibody-catalyzed ozone generation by human neutrophils Bernard M. Babior, Cindy Takeuchi, Julie Ruedi, Abel Gutierrez, and Paul Wentworth, Jr. Proc Natl Acad Sci U S A. 2003 March 18; 100(6): 3031–3034. Published online 2003 February 24. doi: 10.1073/pnas.0530251100.PMCID: PMC152239 Triglyceride accumulation protects against fatty acid-induced lipotoxicity Laura L. Listenberger, Xianlin Han, Sarah E. Lewis, Sylvaine Cases, Robert V. Farese, Jr., Daniel S. Ory, and Jean E. Schaffer Proc Natl Acad Sci U S A. 2003 March 18; 100(6): 3077–3082. Published online 2003 March 10. doi: 10.1073/pnas.0630588100.PMCID: PMC152249 Transcription termination control of the S box system: Direct measurement of S-adenosylmethionine by the leader RNA Brooke A. Murphy McDaniel, Frank J. Grundy, Irina Artsimovitch, and Tina M. Henkin Proc Natl Acad Sci U S A. 2003 March 18; 100(6): 3083–3088. Published online 2003 March 7. doi: 10.1073/pnas.0630422100.PMCID: PMC152250 Metabolic incorporation of unnatural sialic acids into Haemophilus ducreyi lipooligosaccharides Scarlett Goon, Birgit Schilling, Michael V. Tullius, Bradford W. Gibson, and Carolyn R. Bertozzi Proc Natl Acad Sci U S A. 2003 March 18; 100(6): 3089–3094. Published online 2003 March 3. doi: 10.1073/pnas.0437851100.PMCID: PMC152251 A Saccharomyces cerevisiae mutant strain defective in acetyl-CoA carboxylase arrests at the G2/M phase of the cell cycle Walid Al-Feel, James C. DeMar, and Salih J. Wakil Proc Natl Acad Sci U S A. 2003 March 18; 100(6): 3095–3100. Published online 2003 March 7. doi: 10.1073/pnas.0538069100.PMCID: PMC152252 A binding motif for Siah ubiquitin ligase Colin M. House, Ian J. Frew, Huei-Luen Huang, Gerhard Wiche, Nadia Traficante, Edouard Nice, Bruno Catimel, and David D. L. Bowtell Proc Natl Acad Sci U S A. 2003 March 18; 100(6): 3101–3106. Published online 2003 March 7. doi: 10.1073/pnas.0534783100.PMCID: PMC152253 Protein pathway and complex clustering of correlated mRNA and protein expression analyses in Saccharomyces cerevisiae Michael P. Washburn, Antonius Koller, Guy Oshiro, Ryan R. Ulaszek, David Plouffe, Cosmin Deciu, Elizabeth Winzeler, and John R. Yates, III Proc Natl Acad Sci U S A. 2003 March 18; 100(6): 3107–3112. Published online 2003 March 7. doi: 10.1073/pnas.0634629100.PMCID: PMC152254 Loss of p16INK4a results in increased glucocorticoid receptor activity during fibrosarcoma development Ramon Roca, Robert M. Kypta, and Maria d. M. Vivanco Proc Natl Acad Sci U S A. 2003 March 18; 100(6): 3113–3118. Published online 2003 March 6. doi: 10.1073/pnas.0634912100.PMCID: PMC152255 Mutations that affect the ability of the vnd/NK-2 homeoprotein to regulate gene expression: Transgenic alterations and tertiary structure Keita Koizumi, Carla Lintas, Marshall Nirenberg, Jin-Soo Maeng, Jeong-Ho Ju, James W. Mack, James M. Gruschus, Ward F. Odenwald, and James A. Ferretti Proc Natl Acad Sci U S A. 2003 March 18; 100(6): 3119–3124. Published online 2003 March 7. doi: 10.1073/pnas.0438043100.PMCID: PMC152256 Non-heme iron protein: A potential target of nitric oxide in acute cardiac allograft rejection Galen M. Pieper, Nadine L. N. Halligan, Gail Hilton, Eugene A. Konorev, Christopher C. Felix, Allan M. Roza, Mark B. Adams, and Owen W. Griffith Proc Natl Acad Sci U S A. 2003 March 18; 100(6): 3125–3130. Published online 2003 March 6. doi: 10.1073/pnas.0636938100.PMCID: PMC152257 Heat shock protein coinducers with no effect on protein denaturation specifically modulate the membrane lipid phase Zsolt Török, Nelly M. Tsvetkova, Gábor Balogh, Ibolya Horváth, Enikő Nagy, Zoltán Pénzes, Judit Hargitai, Olivier Bensaude, Péter Csermely, John H. Crowe, Bruno Maresca, and László Vígh Proc Natl Acad Sci U S A. 2003 March 18; 100(6): 3131–3136. Published online 2003 March 3. doi: 10.1073/pnas.0438003100.PMCID: PMC152258 The 1.6-Å crystal structure of the class of chaperones represented by Escherichia coli Hsp31 reveals a putative catalytic triad Paulene M. Quigley, Konstantin Korotkov, François Baneyx, and Wim G. J. Hol Proc Natl Acad Sci U S A. 2003 March 18; 100(6): 3137–3142. Published online 2003 March 5. doi: 10.1073/pnas.0530312100.PMCID: PMC152259 Modifying the stereochemistry of an enzyme-catalyzed reaction by directed evolution Gavin J. Williams, Silvie Domann, Adam Nelson, and Alan Berry Proc Natl Acad Sci U S A. 2003 March 18; 100(6): 3143–3148. Published online 2003 March 7. doi: 10.1073/pnas.0635924100.PMCID: PMC152260 From the Cover: Type I polyketide synthase requiring a discrete acyltransferase for polyketide biosynthesis Yi-Qiang Cheng, Gong-Li Tang, and Ben Shen Proc Natl Acad Sci U S A. 2003 March 18; 100(6): 3149–3154. Published online 2003 February 21. doi: 10.1073/pnas.0537286100.PMCID: PMC152261 Liver-specific mRNA for Insig-2 down-regulated by insulin: Implications for fatty acid synthesis Daisuke Yabe, Ryutaro Komuro, Guosheng Liang, Joseph L. Goldstein, and Michael S. Brown Proc Natl Acad Sci U S A. 2003 March 18; 100(6): 3155–3160. Published online 2003 March 6. doi: 10.1073/pnas.0130116100.PMCID: PMC152262 Biophysics High-throughput approach for detection of DNA bending and flexibility based on cyclization Yongli Zhang and Donald M. Crothers Proc Natl Acad Sci U S A. 2003 March 18; 100(6): 3161–3166. Published online 2003 March 10. doi: 10.1073/pnas.0530189100.PMCID: PMC152263 Close identity of a pressure-stabilized intermediate with a kinetic intermediate in protein folding Ryo Kitahara and Kazuyuki Akasaka Proc Natl Acad Sci U S A. 2003 March 18; 100(6): 3167–3172. Published online 2003 March 10. doi: 10.1073/pnas.0630309100.PMCID: PMC152264 Mechanics of DNA packaging in viruses Prashant K. Purohit, Jané Kondev, and Rob Phillips Proc Natl Acad Sci U S A. 2003 March 18; 100(6): 3173–3178. Published online 2003 March 10. doi: 10.1073/pnas.0737893100.PMCID: PMC404299 Spectroscopic and morphological studies of human retinal lipofuscin granules Nicole M. Haralampus-Grynaviski, Laura E. Lamb, Christine M. R. Clancy, Christine Skumatz, Janice M. Burke, Tadeusz Sarna, and John D. Simon Proc Natl Acad Sci U S A. 2003 March 18; 100(6): 3179–3184. Published online 2003 February 28. doi: 10.1073/pnas.0630280100.PMCID: PMC152266 An affibody in complex with a target protein: Structure and coupled folding Elisabet Wahlberg, Christofer Lendel, Magnus Helgstrand, Peter Allard, Vildan Dincbas-Renqvist, Anders Hedqvist, Helena Berglund, Per-Åke Nygren, and Torleif Härd Proc Natl Acad Sci U S A. 2003 March 18; 100(6): 3185–3190. Published online 2003 February 19. doi: 10.1073/pnas.0436086100.PMCID: PMC152267 Structural basis for recognition by an in vitro evolved affibody Martin Högbom, Malin Eklund, Per-Åke Nygren, and Pär Nordlund Proc Natl Acad Sci U S A. 2003 March 18; 100(6): 3191–3196. Published online 2003 February 25. doi: 10.1073/pnas.0436100100.PMCID: PMC404300 Watching proteins fold one molecule at a time Elizabeth Rhoades, Eugene Gussakovsky, and Gilad Haran Proc Natl Acad Sci U S A. 2003 March 18; 100(6): 3197–3202. Published online 2003 February 28. doi: 10.1073/pnas.2628068100.PMCID: PMC152269 An approach to electrical modeling of single and multiple cells Thiruvallur R. Gowrishankar and James C. Weaver Proc Natl Acad Sci U S A. 2003 March 18; 100(6): 3203–3208. Published online 2003 March 7. doi: 10.1073/pnas.0636434100.PMCID: PMC152270 Displacement of the tyrosyl radical cofactor in ribonucleotide reductase obtained by single-crystal high-field EPR and 1.4-Å x-ray data Martin Högbom, Marcus Galander, Martin Andersson, Matthias Kolberg, Wulf Hofbauer, Günter Lassmann, Pär Nordlund, and Friedhelm Lendzian Proc Natl Acad Sci U S A. 2003 March 18; 100(6): 3209–3214. Published online 2003 March 6. doi: 10.1073/pnas.0536684100.PMCID: PMC404301 Discrimination of native protein structures using atom–atom contact scoring Brendan J. McConkey, Vladimir Sobolev, and Marvin Edelman Proc Natl Acad Sci U S A. 2003 March 18; 100(6): 3215–3220. Published online 2003 March 11. doi: 10.1073/pnas.0535768100.PMCID: PMC152272 Cell Biology Heparin-binding EGF-like growth factor and ErbB signaling is essential for heart function Ryo Iwamoto, Satoru Yamazaki, Masanori Asakura, Seiji Takashima, Hidetoshi Hasuwa, Kenji Miyado, Satoshi Adachi, Masafumi Kitakaze, Koji Hashimoto, Gerhard Raab, Daisuke Nanba, Shigeki Higashiyama, Masatsugu Hori, Michael Klagsbrun, and Eisuke Mekada Proc Natl Acad Sci U S A. 2003 March 18; 100(6): 3221–3226. Published online 2003 March 5. doi: 10.1073/pnas.0537588100.PMCID: PMC152273 Myosin isoforms show unique conformations in the actin-bound state Niels Volkmann, Greta Ouyang, Kathleen M. Trybus, David J. DeRosier, Susan Lowey, and Dorit Hanein Proc Natl Acad Sci U S A. 2003 March 18; 100(6): 3227–3232. Published online 2003 February 28. doi: 10.1073/pnas.0536510100.PMCID: PMC152274 Early growth response 1 protein, an upstream gatekeeper of the p53 tumor suppressor, controls replicative senescence Anja Krones-Herzig, Eileen Adamson, and Dan Mercola Proc Natl Acad Sci U S A. 2003 March 18; 100(6): 3233–3238. Published online 2003 March 10. doi: 10.1073/pnas.2628034100.PMCID: PMC152275 The topoisomerase IIβ circular clamp arrests transcription and signals a 26S proteasome pathway Hai Xiao, Yong Mao, Shyamal D. Desai, Nai Zhou, Chun-Yuan Ting, Jaulang Hwang, and Leroy F. Liu Proc Natl Acad Sci U S A. 2003 March 18; 100(6): 3239–3244. Published online 2003 March 10. doi: 10.1073/pnas.0736401100.PMCID: PMC152276 Regulated subset of G1 growth-control genes in response to derepression by the Wnt pathway Sung Hee Baek, Chrissa Kioussi, Paola Briata, Degeng Wang, H. D. Nguyen, Kenneth A. Ohgi, Christopher K. Glass, Anthony Wynshaw-Boris, David W. Rose, and Michael G. Rosenfeld Proc Natl Acad Sci U S A. 2003 March 18; 100(6): 3245–3250. Published online 2003 March 10. doi: 10.1073/pnas.0330217100.PMCID: PMC152277 Senescence-specific gene expression fingerprints reveal cell-type-dependent physical clustering of up-regulated chromosomal loci Hong Zhang, Kuang-Hung Pan, and Stanley N. Cohen Proc Natl Acad Sci U S A. 2003 March 18; 100(6): 3251–3256. Published online 2003 March 7. doi: 10.1073/pnas.2627983100.PMCID: PMC152278 Small ubiquitin-like modifier conjugation regulates nuclear export of TEL, a putative tumor suppressor Lauren D. Wood, Brenda J. Irvin, Giuseppina Nucifora, K. Scott Luce, and Scott W. Hiebert Proc Natl Acad Sci U S A. 2003 March 18; 100(6): 3257–3262. Published online 2003 March 7. doi: 10.1073/pnas.0637114100.PMCID: PMC152279 Proteasome-dependent, ubiquitin-independent degradation of the Rb family of tumor suppressors by the human cytomegalovirus pp71 protein Robert F. Kalejta and Thomas Shenk Proc Natl Acad Sci U S A. 2003 March 18; 100(6): 3263–3268. Published online 2003 March 7. doi: 10.1073/pnas.0538058100.PMCID: PMC152280 The spatial targeting and nuclear matrix binding domains of SRm160 Stefan Wagner, Simion Chiosea, and Jeffrey A. Nickerson Proc Natl Acad Sci U S A. 2003 March 18; 100(6): 3269–3274. Published online 2003 March 6. doi: 10.1073/pnas.0438055100.PMCID: PMC152281 From the Cover: The structure of the inter-SH2 domain of class IA phosphoinositide 3-kinase determined by site-directed spin labeling EPR and homology modeling Zheng Fu, Eliah Aronoff-Spencer, Jonathan M. Backer, and Gary J. Gerfen Proc Natl Acad Sci U S A. 2003 March 18; 100(6): 3275–3280. Published online 2003 March 10. doi: 10.1073/pnas.0535975100.PMCID: PMC152282 The matrix attachment region in the Chinese hamster dihydrofolate reductase origin of replication may be required for local chromatid separation L. D. Mesner, J. L. Hamlin, and P. A. Dijkwel Proc Natl Acad Sci U S A. 2003 March 18; 100(6): 3281–3286. Published online 2003 March 10. doi: 10.1073/pnas.0437791100.PMCID: PMC152283 Developmental Biology Gelsolin is a dorsalizing factor in zebrafish Jyotshnabala Kanungo, Zbynek Kozmik, Shivalingappa K. Swamynathan, and Joram Piatigorsky Proc Natl Acad Sci U S A. 2003 March 18; 100(6): 3287–3292. Published online 2003 March 10. doi: 10.1073/pnas.0634473100.PMCID: PMC152284 Transcriptional network controlled by the trithorax-group gene ash2 in Drosophila melanogaster Sergi Beltran, Enrique Blanco, Florenci Serras, Beatriz Pérez-Villamil, Roderic Guigó, Spyros Artavanis-Tsakonas, and Montserrat Corominas Proc Natl Acad Sci U S A. 2003 March 18; 100(6): 3293–3298. Published online 2003 March 7. doi: 10.1073/pnas.0538075100.PMCID: PMC152285 Mapping Wnt/β-catenin signaling during mouse development and in colorectal tumors Silvia Maretto, Michelangelo Cordenonsi, Sirio Dupont, Paola Braghetta, Vania Broccoli, A. Bassim Hassan, Dino Volpin, Giorgio M. Bressan, and Stefano Piccolo Proc Natl Acad Sci U S A. 2003 March 18; 100(6): 3299–3304. Published online 2003 March 7. doi: 10.1073/pnas.0434590100.PMCID: PMC152286 Identification of genes responsible for osteoblast differentiation from human mesodermal progenitor cells Huilin Qi, Dean J. Aguiar, Shelly M. Williams, Alison La Pean, Wei Pan, and Catherine M. Verfaillie Proc Natl Acad Sci U S A. 2003 March 18; 100(6): 3305–3310. Published online 2003 March 11. doi: 10.1073/pnas.0532693100.PMCID: PMC152287 X-inactivation patch size in human female tissue confounds the assessment of tumor clonality Marco Novelli, Antonio Cossu, Dahmane Oukrif, Alberto Quaglia, Sunil Lakhani, Richard Poulsom, Peter Sasieni, Piera Carta, Marcella Contini, Anna Pasca, Giuseppe Palmieri, Walter Bodmer, Francesco Tanda, and Nick Wright Proc Natl Acad Sci U S A. 2003 March 18; 100(6): 3311–3314. Published online 2003 February 27. doi: 10.1073/pnas.0437825100.PMCID: PMC152288 Maternal induction of ventral fate by zebrafish radar Samuel Sidi, Carole Goutel, Nadine Peyriéras, and Frédéric M. Rosa Proc Natl Acad Sci U S A. 2003 March 18; 100(6): 3315–3320. Published online 2003 February 24. doi: 10.1073/pnas.0530115100.PMCID: PMC152289 Ecology On the pattern of discovery of introduced species Christopher J. Costello and Andrew R. Solow Proc Natl Acad Sci U S A. 2003 March 18; 100(6): 3321–3323. Published online 2003 March 3. doi: 10.1073/pnas.0636536100.PMCID: PMC152290 Evolution Human specific loss of olfactory receptor genes Yoav Gilad, Orna Man, Svante Pääbo, and Doron Lancet Proc Natl Acad Sci U S A. 2003 March 18; 100(6): 3324–3327. Published online 2003 February 28. doi: 10.1073/pnas.0535697100.PMCID: PMC152291 Relaxed selective pressure on an essential component of pheromone transduction in primate evolution Emily R. Liman and Hideki Innan Proc Natl Acad Sci U S A. 2003 March 18; 100(6): 3328–3332. Published online 2003 March 11. doi: 10.1073/pnas.0636123100.PMCID: PMC152292 Cost minimization by helpers in cooperative vertebrates A. F. Russell, L. L. Sharpe, P. N. M. Brotherton, and T. H. Clutton-Brock Proc Natl Acad Sci U S A. 2003 March 18; 100(6): 3333–3338. Published online 2003 March 10. doi: 10.1073/pnas.0636503100.PMCID: PMC152293 Genetics Integrating regulatory motif discovery and genome-wide expression analysis Erin M. Conlon, X. Shirley Liu, Jason D. Lieb, and Jun S. Liu Proc Natl Acad Sci U S A. 2003 March 18; 100(6): 3339–3344. Published online 2003 March 7. doi: 10.1073/pnas.0630591100.PMCID: PMC152294 Novel functions of the phosphatidylinositol metabolic pathway discovered by a chemical genomics screen with wortmannin Amani Zewail, Michael W. Xie, Yi Xing, Lan Lin, P. Fred Zhang, Wei Zou, Jonathan P. Saxe, and Jing Huang Proc Natl Acad Sci U S A. 2003 March 18; 100(6): 3345–3350. Published online 2003 March 3. doi: 10.1073/pnas.0530118100.PMCID: PMC152295 Generalized singular value decomposition for comparative analysis of genome-scale expression data sets of two different organisms Orly Alter, Patrick O. Brown, and David Botstein Proc Natl Acad Sci U S A. 2003 March 18; 100(6): 3351–3356. Published online 2003 March 11. doi: 10.1073/pnas.0530258100.PMCID: PMC152296 An A−71C substitution in a green gene at the second position in the red/green visual-pigment gene array is associated with deutan color-vision deficiency Hisao Ueyama, Yao-Hua Li, Gui-Lian Fu, Patcharee Lertrit, La-ongsri Atchaneeyasakul, Sanae Oda, Shoko Tanabe, Yasuhiro Nishida, Shinichi Yamade, and Iwao Ohkubo Proc Natl Acad Sci U S A. 2003 March 18; 100(6): 3357–3362. Published online 2003 March 7. doi: 10.1073/pnas.0637437100.PMCID: PMC152297 Transposon telomeres are widely distributed in the Drosophila genus: TART elements in the virilis group Elena Casacuberta and Mary-Lou Pardue Proc Natl Acad Sci U S A. 2003 March 18; 100(6): 3363–3368. Published online 2003 March 7. doi: 10.1073/pnas.0230353100.PMCID: PMC152298 Conditional tradeoffs between aging and organismal performance of Indy long-lived mutant flies James H. Marden, Blanka Rogina, Kristi L. Montooth, and Stephen L. Helfand Proc Natl Acad Sci U S A. 2003 March 18; 100(6): 3369–3373. Published online 2003 March 7. doi: 10.1073/pnas.0634985100.PMCID: PMC152299 Sequences in the Aγ–δ intergenic region are not required for stage-specific regulation of the human β-globin gene locus Karin M. L. Gaensler, Zemin Zhang, Chin Lin, Suya Yang, Karin Hardt, and Linda Flebbe-Rehwaldt Proc Natl Acad Sci U S A. 2003 March 18; 100(6): 3374–3379. Published online 2003 March 10. doi: 10.1073/pnas.0634132100.PMCID: PMC152300 Genome-wide single-nucleotide polymorphism analysis defines haplotype patterns in mouse Tim Wiltshire, Mathew T. Pletcher, Serge Batalov, S. Whitney Barnes, Lisa M. Tarantino, Michael P. Cooke, Hua Wu, Kevin Smylie, Andrey Santrosyan, Neal G. Copeland, Nancy A. Jenkins, Francis Kalush, Richard J. Mural, Richard J. Glynne, Steve A. Kay, Mark D. Adams, and Colin F. Fletcher Proc Natl Acad Sci U S A. 2003 March 18; 100(6): 3380–3385. Published online 2003 February 28. doi: 10.1073/pnas.0130101100.PMCID: PMC152301 Immunology Antigen presentation by keratinocytes directs autoimmune skin disease Lian Fan, Brian W. Busser, Traci Q. Lifsted, David Lo, and Terri M. Laufer Proc Natl Acad Sci U S A. 2003 March 18; 100(6): 3386–3391. Published online 2003 March 10. doi: 10.1073/pnas.0437899100.PMCID: PMC152302 Coadministration of HIV vaccine vectors with vaccinia viruses expressing IL-15 but not IL-2 induces long-lasting cellular immunity SangKon Oh, Jay A. Berzofsky, Donald S. Burke, Thomas A. Waldmann, and Liyanage P. Perera Proc Natl Acad Sci U S A. 2003 March 18; 100(6): 3392–3397. Published online 2003 March 7. doi: 10.1073/pnas.0630592100.PMCID: PMC152303 Melanoma inhibitor of apoptosis protein (ML-IAP) is a target for immune-mediated tumor destruction Jan C. Schmollinger, Robert H. Vonderheide, Kara M. Hoar, Britta Maecker, Joachim L. Schultze, F. Stephen Hodi, Robert J. Soiffer, Ken Jung, Marcelo J. Kuroda, Norman L. Letvin, Edward A. Greenfield, Martin Mihm, Jeffery L. Kutok, and Glenn Dranoff Proc Natl Acad Sci U S A. 2003 March 18; 100(6): 3398–3403. Published online 2003 March 7. doi: 10.1073/pnas.0530311100.PMCID: PMC152304 Medical Sciences Significance and therapeutic potential of the natriuretic peptides/cGMP/cGMP-dependent protein kinase pathway in vascular regeneration Kenichi Yamahara, Hiroshi Itoh, Tae-Hwa Chun, Yoshihiro Ogawa, Jun Yamashita, Naoki Sawada, Yasutomo Fukunaga, Masakatsu Sone, Takami Yurugi-Kobayashi, Kazutoshi Miyashita, Hirokazu Tsujimoto, Hyun Kook, Robert Feil, David L. Garbers, Franz Hofmann, and Kazuwa Nakao Proc Natl Acad Sci U S A. 2003 March 18; 100(6): 3404–3409. Published online 2003 March 5. doi: 10.1073/pnas.0538059100.PMCID: PMC152305 Large-scale delineation of secreted protein biomarkers overexpressed in cancer tissue and serum John B. Welsh, Lisa M. Sapinoso, Suzanne G. Kern, David A. Brown, Tao Liu, Asne R. Bauskin, Robyn L. Ward, Nicholas J. Hawkins, David I. Quinn, Pamela J. Russell, Robert L. Sutherland, Samuel N. Breit, Christopher A. Moskaluk, Henry F. Frierson, Jr., and Garret M. Hampton Proc Natl Acad Sci U S A. 2003 March 18; 100(6): 3410–3415. Published online 2003 March 6. doi: 10.1073/pnas.0530278100.PMCID: PMC152306 Potent inhibition of scrapie prion replication in cultured cells by bis-acridines Barnaby C. H. May, Aaron T. Fafarman, Septima B. Hong, Michael Rogers, Leslie W. Deady, Stanley B. Prusiner, and Fred E. Cohen Proc Natl Acad Sci U S A. 2003 March 18; 100(6): 3416–3421. Published online 2003 March 7. doi: 10.1073/pnas.2627988100.PMCID: PMC152307 Wnt-5A augments repopulating capacity and primitive hematopoietic development of human blood stem cells in vivo Barbara Murdoch, Kristin Chadwick, Matthew Martin, Farbod Shojaei, Kavita V. Shah, Lisa Gallacher, Randall T. Moon, and Mickie Bhatia Proc Natl Acad Sci U S A. 2003 March 18; 100(6): 3422–3427. Published online 2003 March 7. doi: 10.1073/pnas.0130233100.PMCID: PMC152308 Pituitary tumor transforming gene-null male mice exhibit impaired pancreatic beta cell proliferation and diabetes Zhiyong Wang, Enrico Moro, Kalman Kovacs, Run Yu, and Shlomo Melmed Proc Natl Acad Sci U S A. 2003 March 18; 100(6): 3428–3432. Published online 2003 March 7. doi: 10.1073/pnas.0638052100.PMCID: PMC152309 The CD8+ cell noncytotoxic anti-HIV response can be blocked by protease inhibitors Carl E. Mackewicz, Charles S. Craik, and Jay A. Levy Proc Natl Acad Sci U S A. 2003 March 18; 100(6): 3433–3438. Published online 2003 March 6. doi: 10.1073/pnas.0630379100.PMCID: PMC152310 Therapeutic photobiomodulation for methanol-induced retinal toxicity J. T. Eells, M. M. Henry, P. Summerfelt, M. T. T. Wong-Riley, E. V. Buchmann, M. Kane, N. T. Whelan, and H. T. Whelan Proc Natl Acad Sci U S A. 2003 March 18; 100(6): 3439–3444. Published online 2003 March 7. doi: 10.1073/pnas.0534746100.PMCID: PMC152311 Enhanced insulin sensitivity in mice lacking ganglioside GM3 Tadashi Yamashita, Akira Hashiramoto, Martin Haluzik, Hiroki Mizukami, Shoshannah Beck, Aaron Norton, Mari Kono, Shuichi Tsuji, Jose Luis Daniotti, Norbert Werth, Roger Sandhoff, Konrad Sandhoff, and Richard L. Proia Proc Natl Acad Sci U S A. 2003 March 18; 100(6): 3445–3449. Published online 2003 March 10. doi: 10.1073/pnas.0635898100.PMCID: PMC152312 Long-term correction of globotriaosylceramide storage in Fabry mice by recombinant adeno-associated virus-mediated gene transfer Jinhee Park, Gary J. Murray, Advait Limaye, Jane M. Quirk, Monique P. Gelderman, Roscoe O. Brady, and Pankaj Qasba Proc Natl Acad Sci U S A. 2003 March 18; 100(6): 3450–3454. Published online 2003 March 6. doi: 10.1073/pnas.0537900100.PMCID: PMC152313 Gene–environment interaction modulated by allelic heterogeneity in inflammatory diseases Mathias Chamaillard, Dana Philpott, Stephen E. Girardin, Habib Zouali, Suzanne Lesage, Fabrice Chareyre, The Hung Bui, Marco Giovannini, Ulrich Zaehringer, Virginie Penard-Lacronique, Philippe J. Sansonetti, Jean-Pierre Hugot, and Gilles Thomas Proc Natl Acad Sci U S A. 2003 March 18; 100(6): 3455–3460. Published online 2003 March 7. doi: 10.1073/pnas.0530276100.PMCID: PMC152314 Microbiology Kinetics of size changes of individual Bacillus thuringiensis spores in response to changes in relative humidity Andrew J. Westphal, P. Buford Price, Terrance J. Leighton, and Katherine E. Wheeler Proc Natl Acad Sci U S A. 2003 March 18; 100(6): 3461–3466. Published online 2003 February 12. doi: 10.1073/pnas.232710999.PMCID: PMC152315 The impact of parietal cells on Helicobacter pylori tropism and host pathology: An analysis using gnotobiotic normal and transgenic mice Andrew J. Syder, Jung D. Oh, Janaki L. Guruge, David O'Donnell, Maria Karlsson, Jason C. Mills, Britta M. Björkholm, and Jeffrey I. Gordon Proc Natl Acad Sci U S A. 2003 March 18; 100(6): 3467–3472. Published online 2003 March 10. doi: 10.1073/pnas.0230380100.PMCID: PMC152316 Link between immune response and parasite synchronization in malaria Igor M. Rouzine and F. Ellis McKenzie Proc Natl Acad Sci U S A. 2003 March 18; 100(6): 3473–3478. Published online 2003 March 5. doi: 10.1073/pnas.262796299.PMCID: PMC152317 Neuroscience Persistence and brain circuitry Debra A. Gusnard, John M. Ollinger, Gordon L. Shulman, C. Robert Cloninger, Joseph L. Price, David C. Van Essen, and Marcus E. Raichle Proc Natl Acad Sci U S A. 2003 March 18; 100(6): 3479–3484. Published online 2003 March 7. doi: 10.1073/pnas.0538050100.PMCID: PMC152318 Control of neurotransmitter release by an internal gel matrix in synaptic vesicles David Reigada, Ismael Díez-Pérez, Pau Gorostiza, Albert Verdaguer, Inmaculada Gómez de Aranda, Oriol Pineda, Jaume Vilarrasa, Jordi Marsal, Joan Blasi, Jordi Aleu, and Carles Solsona Proc Natl Acad Sci U S A. 2003 March 18; 100(6): 3485–3490. Published online 2003 March 10. doi: 10.1073/pnas.0336914100.PMCID: PMC152319 Altered properties of quantal neurotransmitter release at endplates of mice lacking P/Q-type Ca2+ channels Francisco J. Urbano, Erika S. Piedras-Rentería, Kisun Jun, Hee-Sup Shin, Osvaldo D. Uchitel, and Richard W. Tsien Proc Natl Acad Sci U S A. 2003 March 18; 100(6): 3491–3496. Published online 2003 March 6. doi: 10.1073/pnas.0437991100.PMCID: PMC152320 Neuroglobin protects the brain from experimental stroke in vivo Yunjuan Sun, Kunlin Jin, Alyson Peel, Xiao Ou Mao, Lin Xie, and David A. Greenberg Proc Natl Acad Sci U S A. 2003 March 18; 100(6): 3497–3500. Published online 2003 March 5. doi: 10.1073/pnas.0637726100.PMCID: PMC152321 The power of human brain magnetoencephalographic signals can be modulated up or down by changes in an attentive visual task Yanqing Chen, Anil K. Seth, Joseph A. Gally, and Gerald M. Edelman Proc Natl Acad Sci U S A. 2003 March 18; 100(6): 3501–3506. Published online 2003 March 7. doi: 10.1073/pnas.0337630100.PMCID: PMC152322 From the Cover: The impact of the certainty context on the process of choice John Dickhaut, Kevin McCabe, Jennifer C. Nagode, Aldo Rustichini, Kip Smith, and José V. Pardo Proc Natl Acad Sci U S A. 2003 March 18; 100(6): 3536–3541. Published online 2003 March 7. doi: 10.1073/pnas.0530279100.PMCID: PMC404302 Physiology Kinetics of size changes of individual Bacillus thuringiensis spores in response to changes in relative humidity Andrew J. Westphal, P. Buford Price, Terrance J. Leighton, and Katherine E. Wheeler Proc Natl Acad Sci U S A. 2003 March 18; 100(6): 3461–3466. Published online 2003 February 12. doi: 10.1073/pnas.232710999.PMCID: PMC152315 An unexpected requirement for brain-type sodium channels for control of heart rate in the mouse sinoatrial node Sebastian K. G. Maier, Ruth E. Westenbroek, T. T. Yamanushi, H. Dobrzynski, Mark R. Boyett, William A. Catterall, and Todd Scheuer Proc Natl Acad Sci U S A. 2003 March 18; 100(6): 3507–3512. Published online 2003 March 11. doi: 10.1073/pnas.2627986100.PMCID: PMC152323 Plant Biology Intein-mediated assembly of a functional β-glucuronidase in transgenic plants Jianjun Yang, George C. Fox, Jr., and Tina V. Henry-Smith Proc Natl Acad Sci U S A. 2003 March 18; 100(6): 3513–3518. Published online 2003 March 10. doi: 10.1073/pnas.0635899100.PMCID: PMC152324 Interplay of the Arabidopsis nonhost resistance gene NHO1 with bacterial virulence Li Kang, Jianxiong Li, Tiehan Zhao, Fangming Xiao, Xiaoyan Tang, Roger Thilmony, ShengYang He, and Jian-Min Zhou Proc Natl Acad Sci U S A. 2003 March 18; 100(6): 3519–3524. Published online 2003 March 7. doi: 10.1073/pnas.0637377100.PMCID: PMC152325 Increasing vitamin C content of plants through enhanced ascorbate recycling Zhong Chen, Todd E. Young, Jun Ling, Su-Chih Chang, and Daniel R. Gallie Proc Natl Acad Sci U S A. 2003 March 18; 100(6): 3525–3530. Published online 2003 March 6. doi: 10.1073/pnas.0635176100.PMCID: PMC152326 Social Sciences Anthropology The evolution of altruistic punishment Robert Boyd, Herbert Gintis, Samuel Bowles, and Peter J. Richerson Proc Natl Acad Sci U S A. 2003 March 18; 100(6): 3531–3535. Published online 2003 March 11. doi: 10.1073/pnas.0630443100.PMCID: PMC152327 Economic Sciences From the Cover: The impact of the certainty context on the process of choice John Dickhaut, Kevin McCabe, Jennifer C. Nagode, Aldo Rustichini, Kip Smith, and José V. Pardo Proc Natl Acad Sci U S A. 2003 March 18; 100(6): 3536–3541. Published online 2003 March 7. doi: 10.1073/pnas.0530279100.PMCID: PMC404302 Corrections Proc Natl Acad Sci U S A. 2003 March 18; 100(6): 3542. Published online 2003 March 4. doi: 10.1073/pnas.0630528100.PMCID: PMC152227 Corrects: Christopher J. Hupfeld, et al. β-Arrestin 1 down-regulation after insulin treatment is associated with supersensitization of β2 adrenergic receptor Gαs signaling in 3T3-L1 adipocytes. Proc Natl Acad Sci U S A. 2003 January 7; 100(1): 161–166. Proc Natl Acad Sci U S A. 2003 March 18; 100(6): 3542. Published online 2003 February 26. doi: 10.1073/pnas.0630139100.PMCID: PMC152228 Corrects: Katarzyna Lundmark, et al. Transmissibility of systemic amyloidosis by a prion-like mechanism. Proc Natl Acad Sci U S A. 2002 May 14; 99(10): 6979–6984. |