| | This journal provides immediate access to some articles. Commentaries From the Cover: Insights into DNA replication from the third domain of life Bik K. Tye Proc Natl Acad Sci U S A. 2000 March 14; 97(6): 2399–2401. PMCID: PMC33970 The science of literacy: From the laboratory to the classroom Paula Tallal Proc Natl Acad Sci U S A. 2000 March 14; 97(6): 2402–2404. PMCID: PMC33971 Connecting oxidative stress, auxin, and cell cycle regulation
through a plant mitogen-activated protein kinase pathway Heribert Hirt Proc Natl Acad Sci U S A. 2000 March 14; 97(6): 2405–2407. PMCID: PMC33972 Physical Sciences Applied Physical Sciences Patterned deposition of cells and proteins onto surfaces by using
three-dimensional microfluidic systems Daniel T. Chiu, Noo Li Jeon, Sui Huang, Ravi S. Kane, Christopher J. Wargo, Insung S. Choi, Donald E. Ingber, and George M. Whitesides Proc Natl Acad Sci U S A. 2000 March 14; 97(6): 2408–2413. Published online 2000 February 18. PMCID: PMC15942 Visualization of gas flow and diffusion in porous media Lana G. Kaiser, Thomas Meersmann, John W. Logan, and Alexander Pines Proc Natl Acad Sci U S A. 2000 March 14; 97(6): 2414–2418. Published online 2000 March 7. PMCID: PMC15943 Chemistry Combinatorial target-guided ligand assembly: Identification of
potent subtype-selective c-Src inhibitors Dustin J. Maly, Ingrid C. Choong, and Jonathan A. Ellman Proc Natl Acad Sci U S A. 2000 March 14; 97(6): 2419–2424. PMCID: PMC15944 Geology From the Cover: The missing organic molecules on Mars Steven A. Benner, Kevin G. Devine, Lidia N. Matveeva, and David H. Powell Proc Natl Acad Sci U S A. 2000 March 14; 97(6): 2425–2430. Published online 2000 March 7. PMCID: PMC15945 Physics Monopoles and fractional vortices in chiral superconductors G. E. Volovik Proc Natl Acad Sci U S A. 2000 March 14; 97(6): 2431–2436. PMCID: PMC15946 INAUGURAL ARTICLE by a Recently Elected Academy Member: Ultrafast dynamics of many-body processes and fundamental quantum mechanical phenomena in semiconductors Daniel S. Chemla and Jagdeep Shah Proc Natl Acad Sci U S A. 2000 March 14; 97(6): 2437–2444. PMCID: PMC15947 Biological Sciences Agricultural Sciences Isotope-labeled immunoassays without radiation waste Guomin Shan, Wei Huang, Shirley J. Gee, Bruce A. Buchholz, John S. Vogel, and Bruce D. Hammock Proc Natl Acad Sci U S A. 2000 March 14; 97(6): 2445–2449. Published online 2000 March 7. PMCID: PMC15948 Applied Biological Sciences Selecting protein targets for structural genomics of
Pyrobaculum aerophilum: Validating automated fold
assignment methods by using binary hypothesis testing Parag Mallick, Kenneth E. Goodwill, Sorel Fitz-Gibbon, Jeffrey H. Miller, and David Eisenberg Proc Natl Acad Sci U S A. 2000 March 14; 97(6): 2450–2455. Published online 2000 March 7. PMCID: PMC15949 Biochemistry Different functional domains of TAFII250 modulate expression of distinct subsets of mammalian genes Thomas O'Brien and Robert Tjian Proc Natl Acad Sci U S A. 2000 March 14; 97(6): 2456–2461. PMCID: PMC15950 Ribosomal subunit kinase-2 is required for growth factor-stimulated transcription of the c-Fos gene Jens C. Brüning, Jennifer A. Gillette, Yi Zhao, Christian Bjorbaeck, Jörg Kotzka, Birgit Knebel, Haluk Avci, Bettina Hanstein, Philipp Lingohr, David E. Moller, Wilhelm Krone, C. Ronald Kahn, and Dirk Müller-Wieland Proc Natl Acad Sci U S A. 2000 March 14; 97(6): 2462–2467. PMCID: PMC15951 Erythroid Krüppel-like factor is recruited to the CACCC box
in the β-globin promoter but not to the CACCC box in the
γ-globin promoter: The role of the neighboring promoter elements Jong-Soo Lee, Hailong Ngo, David Kim, and Jay H. Chung Proc Natl Acad Sci U S A. 2000 March 14; 97(6): 2468–2473. Published online 2000 March 7. PMCID: PMC15952 Yeast ribonucleotide reductase has a heterodimeric iron-radical-containing subunit Andrei Chabes, Vladimir Domkin, Göran Larsson, Aimin Liu, Astrid Gräslund, Sybren Wijmenga, and Lars Thelander Proc Natl Acad Sci U S A. 2000 March 14; 97(6): 2474–2479. PMCID: PMC15953 On the interpretation of quantitative structure–function
activity relationship data for lactate oxidase Kazuko Yorita, Hideo Misaki, Bruce A. Palfey, and Vincent Massey Proc Natl Acad Sci U S A. 2000 March 14; 97(6): 2480–2485. Published online 2000 March 7. PMCID: PMC15954 Biosynthesis of terpenoids: YgbB protein converts
4-diphosphocytidyl-2C-methyl-d-erythritol 2-phosphate to
2C-methyl-d-erythritol 2,4-cyclodiphosphate Stefan Herz, Juraithip Wungsintaweekul, Christoph A. Schuhr, Stefan Hecht, Holger Lüttgen, Sylvia Sagner, Monika Fellermeier, Wolfgang Eisenreich, Meinhart H. Zenk, Adelbert Bacher, and Felix Rohdich Proc Natl Acad Sci U S A. 2000 March 14; 97(6): 2486–2490. Published online 2000 February 29. PMCID: PMC15955 The interaction of nitric oxide (NO) with the yeast transcription
factor Ace1: A model system for NO-protein thiol interactions with
implications to metal metabolism Masaru Shinyashiki, Kenneth T. Chiang, Christopher H. Switzer, Edith B. Gralla, Joan S. Valentine, Dennis J. Thiele, and Jon M. Fukuto Proc Natl Acad Sci U S A. 2000 March 14; 97(6): 2491–2496. Published online 2000 February 29. PMCID: PMC15956 Physical association of ubiquitin ligases and the 26S proteasome Youming Xie and Alexander Varshavsky Proc Natl Acad Sci U S A. 2000 March 14; 97(6): 2497–2502. Published online 2000 February 25. PMCID: PMC15957 Zinc transfer potentials of the α- and β-clusters of metallothionein are affected by domain interactions in the whole molecule Li-Juan Jiang, Milan Vašák, Bert L. Vallee, and Wolfgang Maret Proc Natl Acad Sci U S A. 2000 March 14; 97(6): 2503–2508. PMCID: PMC15958 The EntF and EntE adenylation domains of Escherichia
coli enterobactin synthetase: Sequestration and selectivity in
acyl-AMP transfers to thiolation domain cosubstrates David E. Ehmann, Cathryn A. Shaw-Reid, Heather C. Losey, and Christopher T. Walsh Proc Natl Acad Sci U S A. 2000 March 14; 97(6): 2509–2514. Published online 2000 February 25. PMCID: PMC15959 Evidence for a requirement for ATP hydrolysis at two distinct steps during a single turnover of the catalytic cycle of human P-glycoprotein Zuben E. Sauna and Suresh V. Ambudkar Proc Natl Acad Sci U S A. 2000 March 14; 97(6): 2515–2520. PMCID: PMC15960 Mammalian thioredoxin reductase: Oxidation of the C-terminal
cysteine/selenocysteine active site forms a thioselenide, and
replacement of selenium with sulfur markedly reduces
catalytic activity Seung-Rock Lee, Shoshana Bar-Noy, Jaeyul Kwon, Rodney L. Levine, Thressa C. Stadtman, and Sue Goo Rhee Proc Natl Acad Sci U S A. 2000 March 14; 97(6): 2521–2526. Published online 2000 February 25. PMCID: PMC15961 Biophysics Protein folding and unfolding on a complex energy landscape Daan Thorn Leeson, Feng Gai, Hector M. Rodriguez, Lydia M. Gregoret, and R. Brian Dyer Proc Natl Acad Sci U S A. 2000 March 14; 97(6): 2527–2532. Published online 2000 February 18. PMCID: PMC15962 Processive movement of single 22S dynein molecules occurs only at
low ATP concentrations Emi Hirakawa, Hideo Higuchi, and Yoko Y. Toyoshima Proc Natl Acad Sci U S A. 2000 March 14; 97(6): 2533–2537. Published online 2000 March 7. PMCID: PMC15963 Extension of transverse relaxation-optimized spectroscopy techniques to allosteric proteins: CO- and paramagnetic fluoromet-hemoglobin [β(15N-valine)] Judith M. Nocek, Kai Huang, and Brian M. Hoffman Proc Natl Acad Sci U S A. 2000 March 14; 97(6): 2538–2543. PMCID: PMC15964 Mechanisms and kinetics of β-hairpin formation D. K. Klimov and D. Thirumalai Proc Natl Acad Sci U S A. 2000 March 14; 97(6): 2544–2549. PMCID: PMC15965 Environment-dependent residue contact energies for proteins Chao Zhang and Sung-Hou Kim Proc Natl Acad Sci U S A. 2000 March 14; 97(6): 2550–2555. Published online 2000 March 7. PMCID: PMC15966 Clustering of connexin 43–enhanced green fluorescent protein gap
junction channels and functional coupling in living cells Feliksas F. Bukauskas, Karen Jordan, Angele Bukauskiene, Michael V. L. Bennett, Paul D. Lampe, Dale W. Laird, and Vytas K. Verselis Proc Natl Acad Sci U S A. 2000 March 14; 97(6): 2556–2561. Published online 2000 March 7. PMCID: PMC15967 The retro-GCN4 leucine zipper sequence forms a stable three-dimensional structure Peer R. E. Mittl, Christine Deillon, David Sargent, Niankun Liu, Stephan Klauser, Richard M. Thomas, Bernd Gutte, and Markus G. Grütter Proc Natl Acad Sci U S A. 2000 March 14; 97(6): 2562–2566. PMCID: PMC15968 Cell Biology Identification and localization of two brefeldin A-inhibited guanine nucleotide-exchange proteins for ADP-ribosylation factors in a macromolecular complex Ryoichi Yamaji, Ronald Adamik, Kazuyo Takeda, Akira Togawa, Gustavo Pacheco-Rodriguez, Victor J. Ferrans, Joel Moss, and Martha Vaughan Proc Natl Acad Sci U S A. 2000 March 14; 97(6): 2567–2572. PMCID: PMC15969 Identification of a natural soluble neuropilin-1 that binds
vascular endothelial growth factor: In vivo expression
and antitumor activity Michael L. Gagnon, Diane R. Bielenberg, Ze'ev Gechtman, Hua-Quan Miao, Seiji Takashima, Shay Soker, and Michael Klagsbrun Proc Natl Acad Sci U S A. 2000 March 14; 97(6): 2573–2578. Published online 2000 February 25. PMCID: PMC15970 Mik1 levels accumulate in S phase and may mediate an intrinsic link between S phase and mitosis Per U. Christensen, Nicola J. Bentley, Rui G. Martinho, Olaf Nielsen, and Antony M. Carr Proc Natl Acad Sci U S A. 2000 March 14; 97(6): 2579–2584. PMCID: PMC15971 Isolation of a vascular cell wall-specific monoclonal antibody
recognizing a cell polarity by using a phage display
subtraction method Naoki Shinohara, Taku Demura, and Hiroo Fukuda Proc Natl Acad Sci U S A. 2000 March 14; 97(6): 2585–2590. Published online 2000 March 7. PMCID: PMC15972 5-Hydroxytryptamine 2B receptor regulates cell-cycle
progression: Cross-talk with tyrosine kinase pathways Canan G. Nebigil, Jean-Marie Launay, Pierre Hickel, Claire Tournois, and Luc Maroteaux Proc Natl Acad Sci U S A. 2000 March 14; 97(6): 2591–2596. Published online 2000 February 25. PMCID: PMC15973 BAR: An apoptosis regulator at the intersection of caspases and Bcl-2 family proteins Hong Zhang, Qunli Xu, Stanislaw Krajewski, Maryla Krajewska, Zhihua Xie, Sally Fuess, Shinichi Kitada, Krzysztof Pawłowski, Adam Godzik, and John C. Reed Proc Natl Acad Sci U S A. 2000 March 14; 97(6): 2597–2602. PMCID: PMC15974 Pleiotrophin signals increased tyrosine phosphorylation of
β-catenin through inactivation of the intrinsic catalytic activity of
the receptor-type protein tyrosine phosphatase β/ζ Kung Meng, A. Rodríguez-Peña, Todor Dimitrov, Wen Chen, Moshe Yamin, Masaharu Noda, and Thomas F. Deuel Proc Natl Acad Sci U S A. 2000 March 14; 97(6): 2603–2608. Published online 2000 March 7. PMCID: PMC15975 Developmental Biology Notch signaling directly controls cell
proliferation in the Drosophila wing disc A. Baonza and A. Garcia-Bellido Proc Natl Acad Sci U S A. 2000 March 14; 97(6): 2609–2614. Published online 2000 March 7. PMCID: PMC15976 From the Cover: Thyroid hormone-dependent metamorphosis in a direct
developing frog Elizabeth M. Callery and Richard P. Elinson Proc Natl Acad Sci U S A. 2000 March 14; 97(6): 2615–2620. Published online 2000 March 7. PMCID: PMC15977 The orphan nuclear receptor Tlx regulates Pax2 and is essential
for vision Ruth T. Yu, Ming-Yi Chiang, Teruyo Tanabe, Mime Kobayashi, Kunio Yasuda, Ronald M. Evans, and Kazuhiko Umesono Proc Natl Acad Sci U S A. 2000 March 14; 97(6): 2621–2625. Published online 2000 March 7. PMCID: PMC15978 Activin receptor-like kinase 1 modulates transforming growth factor-β1 signaling in the regulation of angiogenesis S. Paul Oh, Tsugio Seki, Kendrick A. Goss, Takeshi Imamura, Youngsuk Yi, Patricia K. Donahoe, Li Li, Kohei Miyazono, Peter ten Dijke, Seongjin Kim, and En Li Proc Natl Acad Sci U S A. 2000 March 14; 97(6): 2626–2631. PMCID: PMC15979 Ecology Defensive use of a fecal thatch by a beetle larva
(Hemisphaerota cyanea) Thomas Eisner and Maria Eisner Proc Natl Acad Sci U S A. 2000 March 14; 97(6): 2632–2636. Published online 2000 February 18. PMCID: PMC15980 Learning improves growth rate in grasshoppers Reuven Dukas and Elizabeth A. Bernays Proc Natl Acad Sci U S A. 2000 March 14; 97(6): 2637–2640. Published online 2000 March 7. PMCID: PMC15981 Evolution Linking development with generation of novelty in
mammalian teeth Jukka Jernvall Proc Natl Acad Sci U S A. 2000 March 14; 97(6): 2641–2645. Published online 2000 March 7. PMCID: PMC15982 Widanelfarasia, a diminutive placental from the
late Eocene of Egypt Erik R. Seiffert and Elwyn L. Simons Proc Natl Acad Sci U S A. 2000 March 14; 97(6): 2646–2651. Published online 2000 February 29. PMCID: PMC15983 Genetics Genetic analysis of speciation by means of introgression into
Drosophila melanogaster Kyoichi Sawamura, Andrew W. Davis, and Chung-I Wu Proc Natl Acad Sci U S A. 2000 March 14; 97(6): 2652–2655. Published online 2000 March 7. PMCID: PMC15984 A Bacillus subtilis operon containing genes of
unknown function senses tRNATrp charging and regulates
expression of the genes of tryptophan biosynthesis Joseph P. Sarsero, Enrique Merino, and Charles Yanofsky Proc Natl Acad Sci U S A. 2000 March 14; 97(6): 2656–2661. Published online 2000 March 7. PMCID: PMC15985 Candidate tumor suppressor RIZ is frequently involved in
colorectal carcinogenesis Robert B. Chadwick, Guang-Liang Jiang, Garth A. Bennington, Bo Yuan, Cheryl K. Johnson, Michael W. Stevens, Theodore H. Niemann, Paivi Peltomaki, Shi Huang, and Albert de la Chapelle Proc Natl Acad Sci U S A. 2000 March 14; 97(6): 2662–2667. Published online 2000 February 25. PMCID: PMC15986 Defective embryonic neurogenesis in Ku-deficient but not DNA-dependent protein kinase catalytic subunit-deficient mice Yansong Gu, JoAnn Sekiguchi, Yijie Gao, Pieter Dikkes, Karen Frank, David Ferguson, Paul Hasty, Jerold Chun, and Frederick W. Alt Proc Natl Acad Sci U S A. 2000 March 14; 97(6): 2668–2673. PMCID: PMC15987 The genetics of ivermectin resistance in Caenorhabditis elegans Joseph A. Dent, McHardy M. Smith, Demetrios K. Vassilatis, and Leon Avery Proc Natl Acad Sci U S A. 2000 March 14; 97(6): 2674–2679. PMCID: PMC15988 Gene microarray identification of redox and mitochondrial elements that control resistance or sensitivity to apoptosis D. W. Voehringer, D. L. Hirschberg, J. Xiao, Q. Lu, M. Roederer, C. B. Lock, L. A. Herzenberg, L. Steinman, and L. A. Herzenberg Proc Natl Acad Sci U S A. 2000 March 14; 97(6): 2680–2685. PMCID: PMC15989 Chip interacts with diverse homeodomain proteins and potentiates
Bicoid activity in vivo Emi Torigoi, Idriss M. Bennani-Baïti, Christina Rosen, Katie Gonzalez, Patrick Morcillo, Mark Ptashne, and Dale Dorsett Proc Natl Acad Sci U S A. 2000 March 14; 97(6): 2686–2691. Published online 2000 February 25. PMCID: PMC15990 Human cytomegalovirus UL69 protein is required for efficient
accumulation of infected cells in the G1 phase of the
cell cycle Mansuo Lu Hayashi, Catherine Blankenship, and Thomas Shenk Proc Natl Acad Sci U S A. 2000 March 14; 97(6): 2692–2696. Published online 2000 March 7. PMCID: PMC15991 Immunology Dendritic cells purified from myeloma are primed with
tumor-specific antigen (idiotype) and activate CD4+
T cells Zlatko Dembic, Karl Schenck, and Bjarne Bogen Proc Natl Acad Sci U S A. 2000 March 14; 97(6): 2697–2702. Published online 2000 March 7. PMCID: PMC15992 Estrogen up-regulates Bcl-2 and blocks tolerance induction of
naïve B cells Margaret S. Bynoe, Christine M. Grimaldi, and Betty Diamond Proc Natl Acad Sci U S A. 2000 March 14; 97(6): 2703–2708. Published online 2000 February 29. PMCID: PMC15993 HLA B*5701 is highly associated with restriction of virus
replication in a subgroup of HIV-infected long term nonprogressors Stephen A. Migueles, M. Shirin Sabbaghian, W. Lesley Shupert, Maria P. Bettinotti, Francesco M. Marincola, Lisa Martino, Clair W. Hallahan, Sara M. Selig, David Schwartz, John Sullivan, and Mark Connors Proc Natl Acad Sci U S A. 2000 March 14; 97(6): 2709–2714. Published online 2000 February 29. PMCID: PMC15994 Activation of antitumor cytotoxic T lymphocytes by fusions of
human dendritic cells and breast carcinoma cells Jianlin Gong, David Avigan, Dongshu Chen, Zekui Wu, Shigeo Koido, Masahiro Kashiwaba, and Donald Kufe Proc Natl Acad Sci U S A. 2000 March 14; 97(6): 2715–2718. Published online 2000 February 25. PMCID: PMC15995 Polyclonal antibodies from patients immunized with a globo H-keyhole limpet hemocyanin vaccine: Isolation, quantification, and characterization of immune responses by using totally synthetic immobilized tumor antigens Z.-G. Wang, L. J. Williams, X.-F. Zhang, A. Zatorski, V. Kudryashov, G. Ragupathi, M. Spassova, W. Bornmann, S. F. Slovin, H. I. Scher, P. O. Livingston, K. O. Lloyd, and S. J. Danishefsky Proc Natl Acad Sci U S A. 2000 March 14; 97(6): 2719–2724. PMCID: PMC15996 Postexposure vaccination massively increases the prevalence of
γ-herpesvirus-specific CD8+ T cells but confers
minimal survival advantage on CD4-deficient mice Gabrielle T. Belz, Philip G. Stevenson, Maria R. Castrucci, John D. Altman, and Peter C. Doherty Proc Natl Acad Sci U S A. 2000 March 14; 97(6): 2725–2730. Published online 2000 February 29. PMCID: PMC15997 In vivo natural killer cell activities revealed by
natural killer cell-deficient mice Sungjin Kim, Koho Iizuka, Hector L. Aguila, Irving L. Weissman, and Wayne M. Yokoyama Proc Natl Acad Sci U S A. 2000 March 14; 97(6): 2731–2736. Published online 2000 February 29. PMCID: PMC15998 Posttranscriptional regulation of Bruton's tyrosine kinase
expression in antigen receptor-stimulated splenic B cells Sazuku Nisitani, Anne B. Satterthwaite, Koichi Akashi, Irving L. Weissman, Owen N. Witte, and Matthew I. Wahl Proc Natl Acad Sci U S A. 2000 March 14; 97(6): 2737–2742. Published online 2000 February 25. PMCID: PMC15999 A B-cell receptor-specific selection step governs immature to
mature B cell differentiation Matthew H. Levine, Ann M. Haberman, Derek B. Sant'Angelo, Lynn G. Hannum, Michael P. Cancro, Charles A. Janeway, Jr., and Mark J. Shlomchik Proc Natl Acad Sci U S A. 2000 March 14; 97(6): 2743–2748. Published online 2000 February 25. PMCID: PMC16000 Viral persistence in vivo through selection of
neutralizing antibody-escape variants Adrian Ciurea, Paul Klenerman, Lukas Hunziker, Edit Horvath, Beatrice M. Senn, Adrian F. Ochsenbein, Hans Hengartner, and Rolf M. Zinkernagel Proc Natl Acad Sci U S A. 2000 March 14; 97(6): 2749–2754. Published online 2000 February 25. PMCID: PMC16001 The B cell-restricted adaptor BASH is required for normal
development and antigen receptor-mediated activation of B cells Katsuhiko Hayashi, Ryo Nittono, Noriaki Okamoto, Sachiyo Tsuji, Yasushi Hara, Ryo Goitsuka, and Daisuke Kitamura Proc Natl Acad Sci U S A. 2000 March 14; 97(6): 2755–2760. Published online 2000 February 25. PMCID: PMC16002 Redox regulation of chemokine receptor expression Alessandra Saccani, Simona Saccani, Simone Orlando, Marina Sironi, Sergio Bernasconi, Pietro Ghezzi, Alberto Mantovani, and Antonio Sica Proc Natl Acad Sci U S A. 2000 March 14; 97(6): 2761–2766. PMCID: PMC16003 Medical Sciences Concurrent MRI and diffuse optical tomography of breast after
indocyanine green enhancement Vasilis Ntziachristos, A. G. Yodh, Mitchell Schnall, and Britton Chance Proc Natl Acad Sci U S A. 2000 March 14; 97(6): 2767–2772. Published online 2000 March 7. PMCID: PMC16004 Mantle cell lymphoma is characterized by inactivation
of the ATM gene Claudia Schaffner, Irina Idler, Stephan Stilgenbauer, Hartmut Döhner, and Peter Lichter Proc Natl Acad Sci U S A. 2000 March 14; 97(6): 2773–2778. Published online 2000 March 7. PMCID: PMC16005 Rat strain-specific actions of 17β-estradiol in the mammary
gland: Correlation between estrogen-induced lobuloalveolar
hyperplasia and susceptibility to estrogen-induced mammary cancers Djuana M. E. Harvell, Tracy E. Strecker, Martin Tochacek, Benjamin Xie, Karen L. Pennington, Rodney D. McComb, Shyamal K. Roy, and James D. Shull Proc Natl Acad Sci U S A. 2000 March 14; 97(6): 2779–2784. Published online 2000 February 25. PMCID: PMC16006 A mutant herpes simplex virus type 1 thymidine kinase reporter gene shows improved sensitivity for imaging reporter gene expression with positron emission tomography Sanjiv S. Gambhir, Eileen Bauer, Margaret E. Black, Qianwa Liang, Mark S. Kokoris, Jorge R. Barrio, Meera Iyer, Mohammad Namavari, Michael E. Phelps, and Harvey R. Herschman Proc Natl Acad Sci U S A. 2000 March 14; 97(6): 2785–2790. PMCID: PMC16007 Expression and function of wingless and frizzled homologs in
rheumatoid arthritis Malini Sen, Kevin Lauterbach, Hani El-Gabalawy, Gary S. Firestein, Maripat Corr, and Dennis A. Carson Proc Natl Acad Sci U S A. 2000 March 14; 97(6): 2791–2796. Published online 2000 February 25. PMCID: PMC16008 The amino terminus of the mixed lineage leukemia protein (MLL)
promotes cell cycle arrest and monocytic differentiation Corrado Caslini, Ali Shilatifard, Liping Yang, and Jay L. Hess Proc Natl Acad Sci U S A. 2000 March 14; 97(6): 2797–2802. Published online 2000 February 25. PMCID: PMC16009 Generation and rescue of a murine model of platelet dysfunction:
The Bernard-Soulier syndrome Jerry Ware, Susan Russell, and Zaverio M. Ruggeri Proc Natl Acad Sci U S A. 2000 March 14; 97(6): 2803–2808. Published online 2000 March 7. PMCID: PMC16010 An advanced glycation endproduct cross-link breaker can reverse
age-related increases in myocardial stiffness Mohammad Asif, John Egan, Sara Vasan, Garikiparthy N. Jyothirmayi, Malthi R. Masurekar, Santos Lopez, Chandra Williams, Ramon L. Torres, Dilip Wagle, Peter Ulrich, Anthony Cerami, Michael Brines, and Timothy J. Regan Proc Natl Acad Sci U S A. 2000 March 14; 97(6): 2809–2813. Published online 2000 March 7. PMCID: PMC16011 Detection of leukemia-associated MLL-GAS7
translocation early during chemotherapy with DNA topoisomerase
II inhibitors Maureen D. Megonigal, Nai-Kong V. Cheung, Eric F. Rappaport, Peter C. Nowell, Robert B. Wilson, Douglas H. Jones, Kathakali Addya, Debra G. B. Leonard, Brian H. Kushner, Terence M. Williams, Beverly J. Lange, and Carolyn A. Felix Proc Natl Acad Sci U S A. 2000 March 14; 97(6): 2814–2819. Published online 2000 March 7. PMCID: PMC16012 Glucose stimulates protein modification by O-linked GlcNAc in pancreatic β cells: Linkage of O-linked GlcNAc to β cell death Kan Liu, Andrew J. Paterson, Edward Chin, and Jeffrey E. Kudlow Proc Natl Acad Sci U S A. 2000 March 14; 97(6): 2820–2825. PMCID: PMC16013 Mitochondrial dysfunction during hypoxia/reoxygenation and its correction by anaerobic metabolism of citric acid cycle intermediates Joel M. Weinberg, Manjeri A. Venkatachalam, Nancy F. Roeser, and Itzhak Nissim Proc Natl Acad Sci U S A. 2000 March 14; 97(6): 2826–2831. PMCID: PMC16014 Intracellular processing of endothelial nitric oxide synthase isoforms associated with differences in severity of cardiopulmonary diseases: Cleavage of proteins with aspartate vs. glutamate at position 298 M. Tesauro, W. C. Thompson, P. Rogliani, L. Qi, P. P. Chaudhary, and J. Moss Proc Natl Acad Sci U S A. 2000 March 14; 97(6): 2832–2835. PMCID: PMC16015 Specific association of estrogen receptor β with the cell
cycle spindle assembly checkpoint protein, MAD2 Gerhard Poelzl, Yasuyo Kasai, Naoki Mochizuki, Philip W. Shaul, Myles Brown, and Michael E. Mendelsohn Proc Natl Acad Sci U S A. 2000 March 14; 97(6): 2836–2839. Published online 2000 March 7. PMCID: PMC16016 CD38 expressed on human monocytes: A coaccessory molecule in the
superantigen-induced proliferation Marie-Thérèse Zilber, Stéphane Gregory, Roberto Mallone, Silvia Deaglio, Fabio Malavasi, Dominique Charron, and Catherine Gelin Proc Natl Acad Sci U S A. 2000 March 14; 97(6): 2840–2845. Published online 2000 March 7. PMCID: PMC16017 Stress-induced enhancement of skin immune function: A role for
γ interferon Firdaus S. Dhabhar, Abhay R. Satoskar, Horst Bluethmann, John R. David, and Bruce S. McEwen Proc Natl Acad Sci U S A. 2000 March 14; 97(6): 2846–2851. Published online 2000 March 7. PMCID: PMC16018 Dominant negative down-regulation of endotoxin-induced tumor
necrosis factor α production
by Lpsd/Ran Quan Yuan, Fangping Zhao, Siu-Wah Chung, Peidong Fan, Barnet M. Sultzer, Y. W. Kan, and Peter M. C. Wong Proc Natl Acad Sci U S A. 2000 March 14; 97(6): 2852–2857. Published online 2000 March 7. PMCID: PMC16019 Microbiology A nonpetide integrin antagonist can inhibit epithelial cell
ingestion of Streptococcus pyogenes by blocking
formation of integrin α5β1-fibronectin-M1 protein complexes David Cue, Sarka O. Southern, Peter J. Southern, Jadhar Prabhakar, William Lorelli, Joanne M. Smallheer, Shaker A. Mousa, and P. Patrick Cleary Proc Natl Acad Sci U S A. 2000 March 14; 97(6): 2858–2863. Published online 2000 March 7. PMCID: PMC16020 A protein-based therapeutic for human cytomegalovirus infection François Jean, Laurel Thomas, Sean S. Molloy, Gseping Liu, Michael A. Jarvis, Jay A. Nelson, and Gary Thomas Proc Natl Acad Sci U S A. 2000 March 14; 97(6): 2864–2869. Published online 2000 February 18. PMCID: PMC16021 Neurobiology The olfactory receptor gene repertoire in primates and mouse:
Evidence for reduction of the functional fraction in primates Sylvie Rouquier, Antoine Blancher, and Dominique Giorgi Proc Natl Acad Sci U S A. 2000 March 14; 97(6): 2870–2874. Published online 2000 March 7. PMCID: PMC16022 Caspase-3: A vulnerability factor and final effector in
apoptotic death of dopaminergic neurons in
Parkinson's disease Andreas Hartmann, Stéphane Hunot, Patrick P. Michel, Marie-Paule Muriel, Sheela Vyas, Baptiste A. Faucheux, Annick Mouatt-Prigent, Hélène Turmel, Anu Srinivasan, Merle Ruberg, Gerard I. Evan, Yves Agid, and Etienne C. Hirsch Proc Natl Acad Sci U S A. 2000 March 14; 97(6): 2875–2880. Published online 2000 February 25. PMCID: PMC16023 Decreases in rat extracellular hippocampal glucose concentration
associated with cognitive demand during a spatial task Ewan C. McNay, Thomas M. Fries, and Paul E. Gold Proc Natl Acad Sci U S A. 2000 March 14; 97(6): 2881–2885. Published online 2000 March 7. PMCID: PMC16024 Copper chaperone for superoxide dismutase is essential to
activate mammalian Cu/Zn superoxide dismutase Philip C. Wong, Darrel Waggoner, Jamuna R. Subramaniam, Lino Tessarollo, Thomas B. Bartnikas, Valeria C. Culotta, Donald L. Price, Jeffrey Rothstein, and Jonathan D. Gitlin Proc Natl Acad Sci U S A. 2000 March 14; 97(6): 2886–2891. Published online 2000 February 29. PMCID: PMC16025 Apolipoprotein E isoform-dependent amyloid deposition and
neuritic degeneration in a mouse model of Alzheimer's disease David M. Holtzman, Kelly R. Bales, Tanya Tenkova, Anne M. Fagan, Maia Parsadanian, Leah J. Sartorius, Brian Mackey, John Olney, Daniel McKeel, David Wozniak, and Steven M. Paul Proc Natl Acad Sci U S A. 2000 March 14; 97(6): 2892–2897. Published online 2000 February 29. PMCID: PMC16026 Effects of heat shock, heat shock protein 40 (HDJ-2), and proteasome inhibition on protein aggregation in cellular models of Huntington's disease Andreas Wyttenbach, Jenny Carmichael, Jina Swartz, Robert A. Furlong, Yolanda Narain, Julia Rankin, and David C. Rubinsztein Proc Natl Acad Sci U S A. 2000 March 14; 97(6): 2898–2903. PMCID: PMC16027 Pharmacology A common pharmacophore for epothilone and taxanes: Molecular
basis for drug resistance conferred by tubulin mutations in human
cancer cells Paraskevi Giannakakou, Rick Gussio, Eva Nogales, Kenneth H. Downing, Daniel Zaharevitz, Birgit Bollbuck, George Poy, Dan Sackett, K. C. Nicolaou, and Tito Fojo Proc Natl Acad Sci U S A. 2000 March 14; 97(6): 2904–2909. Published online 2000 February 25. PMCID: PMC16028 Hyperphosphorylated tau and neurofilament and cytoskeletal
disruptions in mice overexpressing human p25, an activator of cdk5 Michael K. Ahlijanian, Nestor X. Barrezueta, Robert D. Williams, Amy Jakowski, Kim P. Kowsz, Sheryl McCarthy, Timothy Coskran, Anthony Carlo, Patricia A. Seymour, John E. Burkhardt, Robert B. Nelson, and John D. McNeish Proc Natl Acad Sci U S A. 2000 March 14; 97(6): 2910–2915. Published online 2000 March 7. PMCID: PMC16029 Physiology Requirement of a leucine residue for (apical) membrane expression of type IIb NaPi cotransporters Zoubida Karim-Jimenez, Nati Hernando, Jürg Biber, and Heini Murer Proc Natl Acad Sci U S A. 2000 March 14; 97(6): 2916–2921. PMCID: PMC16030 The inhibitory effect of hormones associated with stress on Na appetite of sheep R. S. Weisinger, J. R. Blair-West, P. Burns, D. A. Denton, M. J. McKinley, B. Purcell, W. Vale, J. Rivier, and K. Sunagawa Proc Natl Acad Sci U S A. 2000 March 14; 97(6): 2922–2927. Published online 2000 February 25. PMCID: PMC16031 Rapid desensitization of the nitric oxide receptor, soluble guanylyl cyclase, underlies diversity of cellular cGMP responses Tomas C. Bellamy, John Wood, David A. Goodwin, and John Garthwaite Proc Natl Acad Sci U S A. 2000 March 14; 97(6): 2928–2933. PMCID: PMC16032 Plant Biology Probing essential oil biosynthesis and secretion by functional evaluation of expressed sequence tags from mint glandular trichomes B. Markus Lange, Mark R. Wildung, Einar J. Stauber, Christopher Sanchez, Derek Pouchnik, and Rodney Croteau Proc Natl Acad Sci U S A. 2000 March 14; 97(6): 2934–2939. PMCID: PMC16033 From the Cover: Functional analysis of oxidative stress-activated mitogen-activated protein kinase cascade in plants Yelena Kovtun, Wan-Ling Chiu, Guillaume Tena, and Jen Sheen Proc Natl Acad Sci U S A. 2000 March 14; 97(6): 2940–2945. PMCID: PMC16034 Psychology Place recognition monitored by location-driven operant responding
during passive transport of the rat over a circular trajectory D. Klement and J. Bures Proc Natl Acad Sci U S A. 2000 March 14; 97(6): 2946–2951. Published online 2000 February 25. PMCID: PMC16035 Social Sciences Psychology Decreases in rat extracellular hippocampal glucose concentration
associated with cognitive demand during a spatial task Ewan C. McNay, Thomas M. Fries, and Paul E. Gold Proc Natl Acad Sci U S A. 2000 March 14; 97(6): 2881–2885. Published online 2000 March 7. PMCID: PMC16024 From the Cover: Dynamic sensory sensitivity and children's word decoding skills Joel B. Talcott, Caroline Witton, Maggie F. McLean, Peter C. Hansen, Adrian Rees, Gary G. R. Green, and John F. Stein Proc Natl Acad Sci U S A. 2000 March 14; 97(6): 2952–2957. Published online 2000 February 25. PMCID: PMC16036 Correction Proc Natl Acad Sci U S A. 2000 March 14; 97(6): 2958. PMCID: PMC55977 Corrects: Jeong Hee Lee, et al. A highly conserved kinase is an essential component for stress tolerance in yeast and plant cells. Proc Natl Acad Sci U S A. 1999 May 11; 96(10): 5873–5877. |