| | This journal provides immediate access to some articles. Editorial Redesign of PNAS: New Covers for the Journal Diane M. Sullenberger, Kenneth R. Fulton, and Nicholas R. Cozzarelli Proc Natl Acad Sci U S A. 1999 January 5; 96(1): 1. PMCID: PMC33536 Commentaries Transcriptional regulation: Contending with complexity Frank C. P. Holstege and Richard A. Young Proc Natl Acad Sci U S A. 1999 January 5; 96(1): 2–4. PMCID: PMC33537 Why is Hu where? Shuttling of early-response-gene messenger RNA subsets Jack D. Keene Proc Natl Acad Sci U S A. 1999 January 5; 96(1): 5–7. PMCID: PMC33538 Coevolutionary arms races: Is victory possible? Peter Kareiva Proc Natl Acad Sci U S A. 1999 January 5; 96(1): 8–10. PMCID: PMC33539 Physical Sciences Applied Physical Sciences A microfabricated device for sizing and sorting DNA molecules Hou-Pu Chou, Charles Spence, Axel Scherer, and Stephen Quake Proc Natl Acad Sci U S A. 1999 January 5; 96(1): 11–13. PMCID: PMC15083 Engineering An arrayable flow-through microcentrifuge for high-throughput instrumentation Andre Marziali, Thomas D. Willis, and Ronald W. Davis Proc Natl Acad Sci U S A. 1999 January 5; 96(1): 61–66. PMCID: PMC15093 Biological Sciences Applied Biological Sciences Enhancement of cellulose production by expression of sucrose synthase in Acetobacter xylinum Tomonori Nakai, Naoto Tonouchi, Teruko Konishi, Yukiko Kojima, Takayasu Tsuchida, Fumihiro Yoshinaga, Fukumi Sakai, and Takahisa Hayashi Proc Natl Acad Sci U S A. 1999 January 5; 96(1): 14–18. PMCID: PMC15084 The oncogenic transforming potential of the passage of single α particles through mammalian cell nuclei Richard C. Miller, Gerhard Randers-Pehrson, Charles R. Geard, Eric J. Hall, and David J. Brenner Proc Natl Acad Sci U S A. 1999 January 5; 96(1): 19–22. PMCID: PMC15085 Biochemistry CIR, a corepressor linking the DNA binding factor CBF1 to the histone deacetylase complex James J.-D. Hsieh, Sifang Zhou, Lin Chen, David B. Young, and S. Diane Hayward Proc Natl Acad Sci U S A. 1999 January 5; 96(1): 23–28. PMCID: PMC15086 A change in actin conformation associated with filament instability after Pi release Lisa D. Belmont, Albina Orlova, David G. Drubin, and Edward H. Egelman Proc Natl Acad Sci U S A. 1999 January 5; 96(1): 29–34. PMCID: PMC15087 Proton exit from the heme–copper oxidase of Escherichia coli Anne Puustinen and Mårten Wikström Proc Natl Acad Sci U S A. 1999 January 5; 96(1): 35–37. PMCID: PMC15088 Mutagenesis of conserved lysine residues in bacteriophage T5 5′-3′ exonuclease suggests separate mechanisms of endoand exonucleolytic cleavage Scott J. Garforth, Thomas A. Ceska, Dietrich Suck, and Jon R. Sayers Proc Natl Acad Sci U S A. 1999 January 5; 96(1): 38–43. PMCID: PMC15089 Catalytic properties of selenophosphate synthetases: Comparison of the selenocysteine-containing enzyme from Haemophilus influenzae with the corresponding cysteine-containing enzyme from Escherichia coli Gerard M. Lacourciere and Thressa C. Stadtman Proc Natl Acad Sci U S A. 1999 January 5; 96(1): 44–48. PMCID: PMC15090 Mechanisms by which IκB proteins control NF-κB activity Simos Simeonidis, Deborah Stauber, Guoying Chen, Wayne A. Hendrickson, and Dimitris Thanos Proc Natl Acad Sci U S A. 1999 January 5; 96(1): 49–54. PMCID: PMC15091 Homotypic interaction and multimerization of nucleocapsid protein of tomato spotted wilt tospovirus: Identification and characterization of two interacting domains J. F. Uhrig, T.-R. Soellick, C. J. Minke, C. Philipp, J.-W. Kellmann, and P. H. Schreier Proc Natl Acad Sci U S A. 1999 January 5; 96(1): 55–60. PMCID: PMC15092 An arrayable flow-through microcentrifuge for high-throughput instrumentation Andre Marziali, Thomas D. Willis, and Ronald W. Davis Proc Natl Acad Sci U S A. 1999 January 5; 96(1): 61–66. PMCID: PMC15093 Mediator protein mutations that selectively abolish activated transcription Lawrence C. Myers, Claes M. Gustafsson, Kathleen C. Hayashibara, Patrick O. Brown, and Roger D. Kornberg Proc Natl Acad Sci U S A. 1999 January 5; 96(1): 67–72. PMCID: PMC15094 Mechanism of recruitment of DnaB helicase to the replication origin of the plasmid pSC101 Hirock J. Datta, Ghan Shyam Khatri, and Deepak Bastia Proc Natl Acad Sci U S A. 1999 January 5; 96(1): 73–78. PMCID: PMC15095 Cytosolic adenylyl cyclase defines a unique signaling molecule in mammals Jochen Buck, Meeghan L. Sinclair, Lissy Schapal, Martin J. Cann, and Lonny R. Levin Proc Natl Acad Sci U S A. 1999 January 5; 96(1): 79–84. PMCID: PMC15096 Characterization of functionally active subribosomal particles from Thermus aquaticus Philipp Khaitovich, Alexander S. Mankin, Rachel Green, Laura Lancaster, and Harry F. Noller Proc Natl Acad Sci U S A. 1999 January 5; 96(1): 85–90. PMCID: PMC15097 Gene delivery: A single nuclear localization signal peptide is sufficient to carry DNA to the cell nucleus Maria Antonietta Zanta, Pascale Belguise-Valladier, and Jean-Paul Behr Proc Natl Acad Sci U S A. 1999 January 5; 96(1): 91–96. PMCID: PMC15098 Pneumocysterol [(24Z)-ethylidenelanost-8-en-3β-ol], a rare sterol detected in the opportunistic pathogen Pneumocystis carinii hominis: Structural identity and chemical synthesis Edna S. Kaneshiro, Zunika Amit, Mardie M. Swonger, George P. Kreishman, Elwood E. Brooks, Mara Kreishman, Koka Jayasimhulu, Edward J. Parish, Hang Sun, Stephen A. Kizito, and David H. Beach Proc Natl Acad Sci U S A. 1999 January 5; 96(1): 97–102. PMCID: PMC15099 Biophysics A microfabricated device for sizing and sorting DNA molecules Hou-Pu Chou, Charles Spence, Axel Scherer, and Stephen Quake Proc Natl Acad Sci U S A. 1999 January 5; 96(1): 11–13. PMCID: PMC15083 Disordered water within a hydrophobic protein cavity visualized by x-ray crystallography B. Yu, M. Blaber, A. M. Gronenborn, G. M. Clore, and D. L. D. Caspar Proc Natl Acad Sci U S A. 1999 January 5; 96(1): 103–108. PMCID: PMC15100 Cell Biology Maturation of the tyrosine kinase c-src as a kinase and as a substrate depends on the molecular chaperone Hsp90 Yang Xu, Mike A. Singer, and Susan Lindquist Proc Natl Acad Sci U S A. 1999 January 5; 96(1): 109–114. PMCID: PMC15101 Centrosomal control of microtubule dynamics Vladimir Rodionov, Elena Nadezhdina, and Gary Borisy Proc Natl Acad Sci U S A. 1999 January 5; 96(1): 115–120. PMCID: PMC15102 Calcium influx factor is synthesized by yeast and mammalian cells depleted of organellar calcium stores Peter Csutora, Zhengchang Su, Hak Yong Kim, Andrej Bugrim, Kyle W. Cunningham, Richard Nuccitelli, Joel E. Keizer, Michael R. Hanley, J. Edwin Blalock, and Richard B. Marchase Proc Natl Acad Sci U S A. 1999 January 5; 96(1): 121–126. PMCID: PMC15103 Transient and stable gene expression in mammalian cells transduced with a recombinant baculovirus vector J. Patrick Condreay, Sam M. Witherspoon, William C. Clay, and Thomas A. Kost Proc Natl Acad Sci U S A. 1999 January 5; 96(1): 127–132. PMCID: PMC15104 Alendronate mechanism of action: geranylgeraniol, an intermediate in the mevalonate pathway, prevents inhibition of osteoclast formation, bone resorption, and kinase activation in vitro J. E. Fisher, M. J. Rogers, J. M. Halasy, S. P. Luckman, D. E. Hughes, P. J. Masarachia, G. Wesolowski, R. G. G. Russell, G. A. Rodan, and A. A. Reszka Proc Natl Acad Sci U S A. 1999 January 5; 96(1): 133–138. PMCID: PMC15105 Nuclear endpoint of Wnt signaling: Neoplastic transformation induced by transactivating lymphoid-enhancing factor 1 Masahiro Aoki, Andreas Hecht, Ulrich Kruse, Rolf Kemler, and Peter K. Vogt Proc Natl Acad Sci U S A. 1999 January 5; 96(1): 139–144. PMCID: PMC15106 Proapoptotic activity of Caenorhabditis elegans CED-4 protein in Drosophila: Implicated mechanisms for caspase activation Hirotaka Kanuka, Shin Hisahara, Kazunobu Sawamoto, Shin-ichi Shoji, Hideyuki Okano, and Masayuki Miura Proc Natl Acad Sci U S A. 1999 January 5; 96(1): 145–150. PMCID: PMC15107 A bioluminescence resonance energy transfer (BRET) system: Application to interacting circadian clock proteins Yao Xu, David W. Piston, and Carl Hirschie Johnson Proc Natl Acad Sci U S A. 1999 January 5; 96(1): 151–156. PMCID: PMC15108 Developmental Biology Imaging of multicellular large-scale rhythmic calcium waves during zebrafish gastrulation Edwin Gilland, Andrew L. Miller, Eric Karplus, Robert Baker, and Sarah E. Webb Proc Natl Acad Sci U S A. 1999 January 5; 96(1): 157–161. PMCID: PMC15109 Placental failure in mice lacking the homeobox gene Dlx3 Maria I. Morasso, Alexander Grinberg, Gertraud Robinson, Thomas D. Sargent, and Kathleen A. Mahon Proc Natl Acad Sci U S A. 1999 January 5; 96(1): 162–167. PMCID: PMC15110 Evolution Self-incompatibility alleles from Physalis: Implications for historical inference from balanced genetic polymorphisms Adam D. Richman and Joshua R. Kohn Proc Natl Acad Sci U S A. 1999 January 5; 96(1): 168–172. PMCID: PMC15111 Emergence of a dual-catalytic RNA with metal-specific cleavage and ligase activities: The spandrels of RNA evolution Laura F. Landweber and Irina D. Pokrovskaya Proc Natl Acad Sci U S A. 1999 January 5; 96(1): 173–178. PMCID: PMC15112 Genetics Polyglutamine-mediated dysfunction and apoptotic death of a Caenorhabditis elegans sensory neuron Peter W. Faber, Janet R. Alter, Marcy E. MacDonald, and Anne C. Hart Proc Natl Acad Sci U S A. 1999 January 5; 96(1): 179–184. PMCID: PMC15113 Immunology A two-step, two-signal model for the primary activation of precursor helper T cells Peter A. Bretscher Proc Natl Acad Sci U S A. 1999 January 5; 96(1): 185–190. PMCID: PMC15114 Formation of coding joints in V(D)J recombination-inducible severe combined immune deficient pre-B cell lines Yung Chang and Matthew L. Brown Proc Natl Acad Sci U S A. 1999 January 5; 96(1): 191–196. PMCID: PMC15115 A small number of residues in the class II molecule I-Au confer the ability to bind the myelin basic protein peptide Ac1-11 Cecelia I. Pearson, Anand M. Gautam, Ingrid C. Rulifson, Roland S. Liblau, and Hugh O. McDevitt Proc Natl Acad Sci U S A. 1999 January 5; 96(1): 197–202. PMCID: PMC15116 Medical Sciences The BCR-ABL oncoprotein potentially interacts with the xeroderma pigmentosum group B protein Norifumi Takeda, Masabumi Shibuya, and Yoshiro Maru Proc Natl Acad Sci U S A. 1999 January 5; 96(1): 203–207. PMCID: PMC15117 Segregation of steroid receptor coactivator-1 from steroid receptors in mammary epithelium Woo-Shin Shim, James DiRenzo, James A. DeCaprio, Richard J. Santen, Myles Brown, and Meei-Huey Jeng Proc Natl Acad Sci U S A. 1999 January 5; 96(1): 208–213. PMCID: PMC15118 NOEY2 (ARHI), an imprinted putative tumor suppressor gene in ovarian and breast carcinomas Yinhua Yu, Fengji Xu, Hongqi Peng, Xianjun Fang, Shulei Zhao, Yang Li, Bruce Cuevas, Wen-Lin Kuo, Joe W. Gray, Michael Siciliano, Gordon B. Mills, and Robert C. Bast, Jr. Proc Natl Acad Sci U S A. 1999 January 5; 96(1): 214–219. PMCID: PMC15119 Severe cardiomyopathy in mice lacking dystrophin and MyoD Lynn A. Megeney, Boris Kablar, Robert L. S. Perry, Chuyan Ying, Linda May, and Michael A. Rudnicki Proc Natl Acad Sci U S A. 1999 January 5; 96(1): 220–225. PMCID: PMC15120 Decrease in telomerase activity in U-87MG human glioblastomas after treatment with an antagonist of growth hormone-releasing hormone Hippokratis Kiaris and Andrew V. Schally Proc Natl Acad Sci U S A. 1999 January 5; 96(1): 226–231. PMCID: PMC15121 Virus-specific immunity after gene therapy in a murine model of severe combined immunodeficiency Kevin D. Bunting, Kirsten J. Flynn, Janice M. Riberdy, Peter C. Doherty, and Brian P. Sorrentino Proc Natl Acad Sci U S A. 1999 January 5; 96(1): 232–237. PMCID: PMC15122 Toward a cancer therapy with boron-rich oligomeric phosphate diesters that target the cell nucleus Akira Nakanishi, Lufeng Guan, Robert R. Kane, Harumi Kasamatsu, and M. Frederick Hawthorne Proc Natl Acad Sci U S A. 1999 January 5; 96(1): 238–241. PMCID: PMC15123 Microbiology A natural variant of the cysteine protease virulence factor of group A Streptococcus with an arginine-glycine-aspartic acid (RGD) motif preferentially binds human integrins αvβ3 and αIIbβ3 Kathryn E. Stockbauer, Loranne Magoun, Mengyao Liu, Eugene H. Burns, Jr., Siddeswar Gubba, Sarah Renish, Xi Pan, Sarah C. Bodary, Elizabeth Baker, Jenifer Coburn, John M. Leong, and James M. Musser Proc Natl Acad Sci U S A. 1999 January 5; 96(1): 242–247. PMCID: PMC15124 Neurobiology The voltage sensitive Lc-type Ca2+ channel is functionally coupled to the exocytotic machinery Ofer Wiser, Michael Trus, Ana Hernández, Erik Renström, Sebastian Barg, Patrik Rorsman, and Daphne Atlas Proc Natl Acad Sci U S A. 1999 January 5; 96(1): 248–253. PMCID: PMC15125 Neuroprotection with noninvasive neurotrophin delivery to the brain Dafang Wu and William M. Pardridge Proc Natl Acad Sci U S A. 1999 January 5; 96(1): 254–259. PMCID: PMC15126 Neurons in the dorsal column white matter of the spinal cord: Complex neuropil in an unexpected location Catherine Abbadie, Kate Skinner, Igor Mitrovic, and Allan I. Basbaum Proc Natl Acad Sci U S A. 1999 January 5; 96(1): 260–265. PMCID: PMC15127 Pharmacology Structural requirements of ligands for the oxysterol liver X receptors LXRα and LXRβ Bethany A. Janowski, Michael J. Grogan, Stacey A. Jones, G. Bruce Wisely, Steven A. Kliewer, Elias J. Corey, and David J. Mangelsdorf Proc Natl Acad Sci U S A. 1999 January 5; 96(1): 266–271. PMCID: PMC15128 Systemic biosynthesis of prostacyclin by cyclooxygenase (COX)-2: The human pharmacology of a selective inhibitor of COX-2 B. F. McAdam, F. Catella-Lawson, I. A. Mardini, S. Kapoor, J. A. Lawson, and G. A. FitzGerald Proc Natl Acad Sci U S A. 1999 January 5; 96(1): 272–277. PMCID: PMC15129 Physiology Atrial natriuretic peptide and oxytocin induce natriuresis by release of cGMP T. J. Soares, T. M. Coimbra, A. R. Martins, A. G. F. Pereira, E. C. Carnio, L. G. S. Branco, W. I. C. Albuquerque-Araujo, G. de Nucci, A. L. V. Favaretto, J. Gutkowska, S. M. McCann, and J. Antunes-Rodrigues Proc Natl Acad Sci U S A. 1999 January 5; 96(1): 278–283. PMCID: PMC15130 Plant Biology Isolation of a cytokinin gene, ZOG1, encoding zeatin O-glucosyltransferase from Phaseolus lunatus Ruth C. Martin, Machteld C. Mok, and David W. S. Mok Proc Natl Acad Sci U S A. 1999 January 5; 96(1): 284–289. PMCID: PMC15131 The Lateral suppressor (Ls) gene of tomato encodes a new member of the VHIID protein family Karin Schumacher, Thomas Schmitt, Mathias Rossberg, Gregor Schmitz, and Klaus Theres Proc Natl Acad Sci U S A. 1999 January 5; 96(1): 290–295. PMCID: PMC15132 Genes controlling fertilization-independent seed development in
Arabidopsis thaliana Ming Luo, Pierre Bilodeau, Anna Koltunow, Elizabeth S. Dennis, W. James Peacock, and Abdul M. Chaudhury Proc Natl Acad Sci U S A. 1999 January 5; 96(1): 296–301. PMCID: PMC15133 Diversity and molecular evolution of the RPS2 resistance gene in Arabidopsis thaliana Ana Lucia Caicedo, Barbara A. Schaal, and Barbara N. Kunkel Proc Natl Acad Sci U S A. 1999 January 5; 96(1): 302–306. PMCID: PMC15134 Psychology Mechanisms of color constancy under nearly natural viewing J. M. Kraft and D. H. Brainard Proc Natl Acad Sci U S A. 1999 January 5; 96(1): 307–312. PMCID: PMC15135 Social Sciences Anthropology Evidence of hominid-like precision grip capability in the hand of the Miocene ape Oreopithecus Salvador Moyà-Solà, Meike Köhler, and Lorenzo Rook Proc Natl Acad Sci U S A. 1999 January 5; 96(1): 313–317. PMCID: PMC15136 Corrections Proc Natl Acad Sci U S A. 1999 January 5; 96(1): 318. PMCID: PMC55996 Corrects: Hiroaki Kawasaki, et al. A Rap guanine nucleotide exchange factor enriched highly in the basal ganglia. Proc Natl Acad Sci U S A. 1998 October 27; 95(22): 13278–13283. |