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Volume 98(3);  January 30, 2001
Introduction
Searching for an alien haven in the heavens
Bridget C. Coughlin
Proc Natl Acad Sci U S A. 2001 January 30; 98(3): 796.
PMCID: PMC33369
Commentaries
Order emerging from chaos in human evolutionary genetics
Alan R. Rogers
Proc Natl Acad Sci U S A. 2001 January 30; 98(3): 779–780.
PMCID: PMC33363
DNA replication blockade impairs p53-transactivation
Rishu Takimoto and Wafik S. El-Deiry
Proc Natl Acad Sci U S A. 2001 January 30; 98(3): 781–783.
PMCID: PMC33364
Plant mitogen-activated protein kinase cascades: Negative regulatory roles turn out positive
Andrew F. Bent
Proc Natl Acad Sci U S A. 2001 January 30; 98(3): 784–786.
PMCID: PMC33365
PDZ domains: More than just a glue
Ilya Bezprozvanny and Anton Maximov
Proc Natl Acad Sci U S A. 2001 January 30; 98(3): 787–789.
PMCID: PMC33366
Polycystic kidney disease: In danger of being X-rated?
Jared J. Grantham and James P. Calvet
Proc Natl Acad Sci U S A. 2001 January 30; 98(3): 790–792.
PMCID: PMC33367
How might cannabinoids influence sexual behavior?
Nephi Stella
Proc Natl Acad Sci U S A. 2001 January 30; 98(3): 793–795.
PMCID: PMC33368
Perspective
Special Feature: State-of-the-art instruments for detecting extraterrestrial life
Jeffrey L. Bada
Proc Natl Acad Sci U S A. 2001 January 30; 98(3): 797–800.
PMCID: PMC33370
Special Feature: Possible ecosystems and the search for life on Europa
Christopher F. Chyba and Cynthia B. Phillips
Proc Natl Acad Sci U S A. 2001 January 30; 98(3): 801–804.
PMCID: PMC33371
Special Feature: The universal nature of biochemistry
Norman R. Pace
Proc Natl Acad Sci U S A. 2001 January 30; 98(3): 805–808.
PMCID: PMC33372
Special Features
Searching for an alien haven in the heavens
Bridget C. Coughlin
Proc Natl Acad Sci U S A. 2001 January 30; 98(3): 796.
PMCID: PMC33369
Special Feature: State-of-the-art instruments for detecting extraterrestrial life
Jeffrey L. Bada
Proc Natl Acad Sci U S A. 2001 January 30; 98(3): 797–800.
PMCID: PMC33370
Special Feature: Possible ecosystems and the search for life on Europa
Christopher F. Chyba and Cynthia B. Phillips
Proc Natl Acad Sci U S A. 2001 January 30; 98(3): 801–804.
PMCID: PMC33371
Special Feature: The universal nature of biochemistry
Norman R. Pace
Proc Natl Acad Sci U S A. 2001 January 30; 98(3): 805–808.
PMCID: PMC33372
Special Feature: The occurrence of Jovian planets and the habitability of planetary systems
Jonathan I. Lunine
Proc Natl Acad Sci U S A. 2001 January 30; 98(3): 809–814.
PMCID: PMC14664
Special Feature: Self-assembling amphiphilic molecules: Synthesis in simulated interstellar/precometary ices
Jason P. Dworkin, David W. Deamer, Scott A. Sandford, and Louis J. Allamandola
Proc Natl Acad Sci U S A. 2001 January 30; 98(3): 815–819.
PMCID: PMC14665
Special Feature: From the Cover:
Differential adsorption of nucleic acid bases: Relevance to the origin of life
Stephen J. Sowerby, Corey A. Cohn, Wolfgang M. Heckl, and Nils G. Holm
Proc Natl Acad Sci U S A. 2001 January 30; 98(3): 820–822.
PMCID: PMC14666
Special Feature: In situ laser-Raman imagery of Precambrian microscopic fossils
Anatoliy B. Kudryavtsev, J. William Schopf, David G. Agresti, and Thomas J. Wdowiak
Proc Natl Acad Sci U S A. 2001 January 30; 98(3): 823–826.
PMCID: PMC14667
Special Feature: Pre-Global Surveyor evidence for Martian ground water
Thomas M. Donahue
Proc Natl Acad Sci U S A. 2001 January 30; 98(3): 827–830.
PMCID: PMC14668
Physical Sciences
Applied Mathematics
Evolution of treatment effects over time: Empirical insight from recursive cumulative metaanalyses
John P. A. Ioannidis and Joseph Lau
Proc Natl Acad Sci U S A. 2001 January 30; 98(3): 831–836. Published online 2001 January 23.
PMCID: PMC14669
A stochastic model for the self-similar heterogeneity of regional organ blood flow
Wayne S. Kendal
Proc Natl Acad Sci U S A. 2001 January 30; 98(3): 837–841. Published online 2001 January 23.
PMCID: PMC14670
Astronomy
Special Feature: The occurrence of Jovian planets and the habitability of planetary systems
Jonathan I. Lunine
Proc Natl Acad Sci U S A. 2001 January 30; 98(3): 809–814.
PMCID: PMC14664
Chemistry
Special Feature: Self-assembling amphiphilic molecules: Synthesis in simulated interstellar/precometary ices
Jason P. Dworkin, David W. Deamer, Scott A. Sandford, and Louis J. Allamandola
Proc Natl Acad Sci U S A. 2001 January 30; 98(3): 815–819.
PMCID: PMC14665
Special Feature: From the Cover:
Differential adsorption of nucleic acid bases: Relevance to the origin of life
Stephen J. Sowerby, Corey A. Cohn, Wolfgang M. Heckl, and Nils G. Holm
Proc Natl Acad Sci U S A. 2001 January 30; 98(3): 820–822.
PMCID: PMC14666
AB-polymer networks based on oligo([var epsilon]-caprolactone) segments showing shape-memory properties
Andreas Lendlein, Annette M. Schmidt, and Robert Langer
Proc Natl Acad Sci U S A. 2001 January 30; 98(3): 842–847. Published online 2001 January 23.
PMCID: PMC14671
Convex Arrhenius plots and their interpretation
Donald G. Truhlar and Amnon Kohen
Proc Natl Acad Sci U S A. 2001 January 30; 98(3): 848–851.
PMCID: PMC14672
Monolayers of derivatized poly(l-lysine)-grafted poly(ethylene glycol) on metal oxides as a class of biomolecular interfaces
L. A. Ruiz-Taylor, T. L. Martin, F. G. Zaugg, K. Witte, P. Indermuhle, S. Nock, and P. Wagner
Proc Natl Acad Sci U S A. 2001 January 30; 98(3): 852–857.
PMCID: PMC14673
Geology
Special Feature: In situ laser-Raman imagery of Precambrian microscopic fossils
Anatoliy B. Kudryavtsev, J. William Schopf, David G. Agresti, and Thomas J. Wdowiak
Proc Natl Acad Sci U S A. 2001 January 30; 98(3): 823–826.
PMCID: PMC14667
Geophysics
Special Feature: Pre-Global Surveyor evidence for Martian ground water
Thomas M. Donahue
Proc Natl Acad Sci U S A. 2001 January 30; 98(3): 827–830.
PMCID: PMC14668
Biological Sciences
Anthropology
Distinctive genetic signatures in the Libyan Jews
Noah A. Rosenberg, Eilon Woolf, Jonathan K. Pritchard, Tamar Schaap, Dov Gefel, Isaac Shpirer, Uri Lavi, Batsheva Bonné-Tamir, Jossi Hillel, and Marcus W. Feldman
Proc Natl Acad Sci U S A. 2001 January 30; 98(3): 858–863.
PMCID: PMC14674
A highly variable segment of human subterminal 16p reveals a history of population growth for modern humans outside Africa
Santos Alonso and John A. L. Armour
Proc Natl Acad Sci U S A. 2001 January 30; 98(3): 864–869. Published online 2000 December 19.
PMCID: PMC14675
Biochemistry
Convex Arrhenius plots and their interpretation
Donald G. Truhlar and Amnon Kohen
Proc Natl Acad Sci U S A. 2001 January 30; 98(3): 848–851.
PMCID: PMC14672
De novo design and characterization of an apolar helical hairpin peptide at atomic resolution: Compaction mediated by weak interactions
Udupi A. Ramagopal, Suryanarayanarao Ramakumar, Dinkar Sahal, and Virander S. Chauhan
Proc Natl Acad Sci U S A. 2001 January 30; 98(3): 870–874.
PMCID: PMC14676
Overexpression of the inositol phosphatase SopB in human 293 cells stimulates cellular chloride influx and inhibits nuclear mRNA export
Yucheng Feng, Susan R. Wente, and Philip W. Majerus
Proc Natl Acad Sci U S A. 2001 January 30; 98(3): 875–879. Published online 2001 January 16.
PMCID: PMC14677
Polar side chains drive the association of model transmembrane peptides
Holly Gratkowski, James D. Lear, and William F. DeGrado
Proc Natl Acad Sci U S A. 2001 January 30; 98(3): 880–885.
PMCID: PMC14678
Ribosome shunt is essential for infectivity of cauliflower mosaic virus
Mikhail M. Pooggin, Johannes Fütterer, Konstantin G. Skryabin, and Thomas Hohn
Proc Natl Acad Sci U S A. 2001 January 30; 98(3): 886–891.
PMCID: PMC14679
Bacterial RNA polymerase subunit ω and eukaryotic RNA polymerase subunit RPB6 are sequence, structural, and functional homologs and promote RNA polymerase assembly
Leonid Minakhin, Sechal Bhagat, Adrian Brunning, Elizabeth A. Campbell, Seth A. Darst, Richard H. Ebright, and Konstantin Severinov
Proc Natl Acad Sci U S A. 2001 January 30; 98(3): 892–897.
PMCID: PMC14680
Rotation of the c subunit oligomer in fully functional F1Fo ATP synthase
Satoshi P. Tsunoda, Robert Aggeler, Masasuke Yoshida, and Roderick A. Capaldi
Proc Natl Acad Sci U S A. 2001 January 30; 98(3): 898–902. Published online 2001 January 23.
PMCID: PMC14681
Directed evolution of ampicillin-resistant activity from a functionally unrelated DNA fragment: A laboratory model of molecular evolution
Takato Yano and Hiroyuki Kagamiyama
Proc Natl Acad Sci U S A. 2001 January 30; 98(3): 903–907. Published online 2001 January 23.
PMCID: PMC14682
The critical role of DNA in the equilibrium between OmpR and phosphorylated OmpR mediated by EnvZ in Escherichia coli
Ling Qin, Takeshi Yoshida, and Masayori Inouye
Proc Natl Acad Sci U S A. 2001 January 30; 98(3): 908–913. Published online 2001 January 23.
PMCID: PMC14683
Subunit interactions influence the biochemical and biological properties of Hsp104
Eric C. Schirmer, Danielle M. Ware, Christine Queitsch, Anthony S. Kowal, and Susan L. Lindquist
Proc Natl Acad Sci U S A. 2001 January 30; 98(3): 914–919. Published online 2001 January 23.
PMCID: PMC14684
Protein–protein interactions with subunits of human nuclear RNase P
Taijiao Jiang and Sidney Altman
Proc Natl Acad Sci U S A. 2001 January 30; 98(3): 920–925. Published online 2001 January 16.
PMCID: PMC14685
Characterization of a quinone reductase activity for the mitomycin C binding protein (MRD): Functional switching from a drug-activating enzyme to a drug-binding protein
Min He, Paul J. Sheldon, and David H. Sherman
Proc Natl Acad Sci U S A. 2001 January 30; 98(3): 926–931. Published online 2001 January 23.
PMCID: PMC14686
An unusual isopentenyl diphosphate isomerase found in the mevalonate pathway gene cluster from Streptomyces sp. strain CL190
Kazuhide Kaneda, Tomohisa Kuzuyama, Motoki Takagi, Yoichi Hayakawa, and Haruo Seto
Proc Natl Acad Sci U S A. 2001 January 30; 98(3): 932–937. Published online 2001 January 23.
PMCID: PMC14687
Caspase-2 pre-mRNA alternative splicing: Identification of an intronic element containing a decoy 3′ acceptor site
Jocelyn Côté, Sophie Dupuis, Zhi-Hong Jiang, and Jane Y. Wu
Proc Natl Acad Sci U S A. 2001 January 30; 98(3): 938–943. Published online 2001 January 23.
PMCID: PMC14688
Molecular clocks
Noah E. Robinson and Arthur B. Robinson
Proc Natl Acad Sci U S A. 2001 January 30; 98(3): 944–949.
PMCID: PMC14689
Biophysics
Selectin receptor–ligand bonds: Formation limited by shear rate and dissociation governed by the Bell model
Shuqi Chen and Timothy A. Springer
Proc Natl Acad Sci U S A. 2001 January 30; 98(3): 950–955.
PMCID: PMC14690
Changes in protein conformational mobility upon activation of extracellular regulated protein kinase-2 as detected by hydrogen exchange
Andrew N. Hoofnagle, Katheryn A. Resing, Elizabeth J. Goldsmith, and Natalie G. Ahn
Proc Natl Acad Sci U S A. 2001 January 30; 98(3): 956–961.
PMCID: PMC14691
Primary reactions of sensory rhodopsins
I. Lutz, A. Sieg, A. A. Wegener, M. Engelhard, I. Boche, M. Otsuka, D. Oesterhelt, J. Wachtveitl, and W. Zinth
Proc Natl Acad Sci U S A. 2001 January 30; 98(3): 962–967. Published online 2001 January 16.
PMCID: PMC14692
Dynamics of site juxtaposition in supercoiled DNA
Jing Huang, Tamar Schlick, and Alexander Vologodskii
Proc Natl Acad Sci U S A. 2001 January 30; 98(3): 968–973.
PMCID: PMC14693
Cell Biology
Regulation of Smad degradation and activity by Smurf2, an E3 ubiquitin ligase
Ying Zhang, Chenbei Chang, Daniel J. Gehling, Ali Hemmati-Brivanlou, and Rik Derynck
Proc Natl Acad Sci U S A. 2001 January 30; 98(3): 974–979.
PMCID: PMC14694
The MinE ring required for proper placement of the division site is a mobile structure that changes its cellular location during the Escherichia coli division cycle
Xiaoli Fu, Yu-Ling Shih, Yan Zhang, and Lawrence I. Rothfield
Proc Natl Acad Sci U S A. 2001 January 30; 98(3): 980–985. Published online 2001 January 23.
PMCID: PMC14695
Mouse model of congenital polycythemia: Homologous replacement of murine gene by mutant human erythropoietin receptor gene
Vladimir Divoky, Zhiyong Liu, Thomas M. Ryan, Jaroslav F. Prchal, Tim M. Townes, and Josef T. Prchal
Proc Natl Acad Sci U S A. 2001 January 30; 98(3): 986–991.
PMCID: PMC14696
Defective repression of c-myc in breast cancer cells: A loss at the core of the transforming growth factor β growth arrest program
Chang-Rung Chen, Yibin Kang, and Joan Massagué
Proc Natl Acad Sci U S A. 2001 January 30; 98(3): 992–999.
PMCID: PMC14697
Aquaporins in Saccharomyces: Characterization of a second functional water channel protein
Jennifer M. Carbrey, Mélanie Bonhivers, Jef D. Boeke, and Peter Agre
Proc Natl Acad Sci U S A. 2001 January 30; 98(3): 1000–1005.
PMCID: PMC14698
The midblastula transition in Xenopus embryos activates multiple pathways to prevent apoptosis in response to DNA damage
Carla V. Finkielstein, Andrea L. Lewellyn, and James L. Maller
Proc Natl Acad Sci U S A. 2001 January 30; 98(3): 1006–1011.
PMCID: PMC14699
Proteins associated with the promyelocytic leukemia gene product (PML)-containing nuclear body move to the nucleolus upon inhibition of proteasome-dependent protein degradation
Karin Mattsson, Katja Pokrovskaja, Csaba Kiss, George Klein, and Laszlo Szekely
Proc Natl Acad Sci U S A. 2001 January 30; 98(3): 1012–1017. Published online 2001 January 23.
PMCID: PMC14700
Characterization of Rny1, the Saccharomyces cerevisiae member of the T2 RNase family of RNases: Unexpected functions for ancient enzymes?
Gustavo C. MacIntosh, Pauline A. Bariola, Ed Newbigin, and Pamela J. Green
Proc Natl Acad Sci U S A. 2001 January 30; 98(3): 1018–1023.
PMCID: PMC14701
Interaction of endostatin with integrins implicated in angiogenesis
Marko Rehn, Tanja Veikkola, Eola Kukk-Valdre, Hitoshi Nakamura, Maritta Ilmonen, Christian R. Lombardo, Taina Pihlajaniemi, Kari Alitalo, and Kristiina Vuori
Proc Natl Acad Sci U S A. 2001 January 30; 98(3): 1024–1029. Published online 2001 January 23.
PMCID: PMC14702
REF proteins mediate the export of spliced and unspliced mRNAs from the nucleus
João P. Rodrigues, Michaela Rode, David Gatfield, Benjamin J. Blencowe, Maria Carmo-Fonseca, and Elisa Izaurralde
Proc Natl Acad Sci U S A. 2001 January 30; 98(3): 1030–1035. Published online 2001 January 23.
PMCID: PMC14703
From the Cover:
p53 accumulates but is functionally impaired when DNA synthesis is blocked
Vanesa Gottifredi, Sheau-Yann Shieh, Yoichi Taya, and Carol Prives
Proc Natl Acad Sci U S A. 2001 January 30; 98(3): 1036–1041. Published online 2001 January 23.
PMCID: PMC14704
Integrin-mediated mechanotransduction requires its dynamic interaction with specific extracellular matrix (ECM) ligands
Shila Jalali, Miguel A. del Pozo, Kuang-Den Chen, Hui Miao, Yi-Shuan Li, Martin A. Schwartz, John Y.-J. Shyy, and Shu Chien
Proc Natl Acad Sci U S A. 2001 January 30; 98(3): 1042–1046. Published online 2001 January 23.
PMCID: PMC14705
Developmental Biology
Cellular and molecular responses of the uterus to embryo implantation can be elicited by locally applied growth factors
Bibhash C. Paria, Wen-ge Ma, Jian Tan, Shefali Raja, Sonjoy K. Das, Sudhansu K. Dey, and Brigid L. M. Hogan
Proc Natl Acad Sci U S A. 2001 January 30; 98(3): 1047–1052.
PMCID: PMC14706
Expression pattern of Drosophila ret suggests a common ancestral origin between the metamorphosis precursors in insect endoderm and the vertebrate enteric neurons
Mounou Hahn and J. Michael Bishop
Proc Natl Acad Sci U S A. 2001 January 30; 98(3): 1053–1058. Published online 2001 January 16.
PMCID: PMC14707
Failure of ductus arteriosus closure and remodeling in neonatal mice deficient in cyclooxygenase-1 and cyclooxygenase-2
Charles D. Loftin, Darshini B. Trivedi, Howard F. Tiano, James A. Clark, Christopher A. Lee, Jonathan A. Epstein, Scott G. Morham, Matthew D. Breyer, MyTrang Nguyen, Beau M. Hawkins, Jennifer L. Goulet, Oliver Smithies, Beverly H. Koller, and Robert Langenbach
Proc Natl Acad Sci U S A. 2001 January 30; 98(3): 1059–1064. Published online 2001 January 23.
PMCID: PMC14708
PDX:PBX complexes are required for normal proliferation of pancreatic cells during development
Sanjoy Dutta, Maureen Gannon, Bernard Peers, Chris Wright, Susan Bonner-Weir, and Marc Montminy
Proc Natl Acad Sci U S A. 2001 January 30; 98(3): 1065–1070. Published online 2001 January 16.
PMCID: PMC14709
Fertile and diploid nuclear transplants derived from embryonic cells of a small laboratory fish, medaka (Oryzias latipes)
Yuko Wakamatsu, Bensheng Ju, Inna Pristyaznhyuk, Katsutoshi Niwa, Tatiana Ladygina, Masato Kinoshita, Kazuo Araki, and Kenjiro Ozato
Proc Natl Acad Sci U S A. 2001 January 30; 98(3): 1071–1076.
PMCID: PMC14710
Reprogramming of telomerase activity and rebuilding of telomere length in cloned cattle
Dean H. Betts, Vilceu Bordignon, Jonathan R. Hill, Quinton Winger, Mark E. Westhusin, Lawrence C. Smith, and W. Allan King
Proc Natl Acad Sci U S A. 2001 January 30; 98(3): 1077–1082. Published online 2001 January 16.
PMCID: PMC14711
Ecology
Extrafloral nectar production of the ant-associated plant, Macaranga tanarius, is an induced, indirect, defensive response elicited by jasmonic acid
Martin Heil, Thomas Koch, Andrea Hilpert, Brigitte Fiala, Wilhelm Boland, and K. Eduard Linsenmair
Proc Natl Acad Sci U S A. 2001 January 30; 98(3): 1083–1088. Published online 2001 January 16.
PMCID: PMC14712
To walk or to fly? How birds choose among foraging modes
Luis M. Bautista, Joost Tinbergen, and Alejandro Kacelnik
Proc Natl Acad Sci U S A. 2001 January 30; 98(3): 1089–1094.
PMCID: PMC14713
Patterns of spread in biological invasions dominated by long-distance jump dispersal: Insights from Argentine ants
Andrew V. Suarez, David A. Holway, and Ted J. Case
Proc Natl Acad Sci U S A. 2001 January 30; 98(3): 1095–1100.
PMCID: PMC14714
Evolution
An orphaned mammalian β-globin gene of ancient evolutionary origin
David Wheeler, Rory Hope, Steven J. B. Cooper, Gaynor Dolman, Graham C. Webb, Cynthia D. K. Bottema, Andrew A. Gooley, Morris Goodman, and Robert A. B. Holland
Proc Natl Acad Sci U S A. 2001 January 30; 98(3): 1101–1106.
PMCID: PMC14715
Environmental stress and mutational load in diploid strains of the yeast Saccharomyces cerevisiae
Krzysztof Szafraniec, Rhona H. Borts, and Ryszard Korona
Proc Natl Acad Sci U S A. 2001 January 30; 98(3): 1107–1112. Published online 2001 January 16.
PMCID: PMC14716
Fitness effects of advantageous mutations in evolving Escherichia coli populations
Marianne Imhof and Christian Schlötterer
Proc Natl Acad Sci U S A. 2001 January 30; 98(3): 1113–1117.
PMCID: PMC14717
Genetics
A mouse model of multiple endocrine neoplasia, type 1, develops multiple endocrine tumors
Judy S. Crabtree, Peter C. Scacheri, Jerrold M. Ward, Lisa Garrett-Beal, Michael R. Emmert-Buck, Keith A. Edgemon, Dominique Lorang, Steven K. Libutti, Settara C. Chandrasekharappa, Stephen J. Marx, Allen M. Spiegel, and Francis S. Collins
Proc Natl Acad Sci U S A. 2001 January 30; 98(3): 1118–1123.
PMCID: PMC14718
Expression profiling reveals fundamental biological differences in acute myeloid leukemia with isolated trisomy 8 and normal cytogenetics
Kimmo Virtaneva, Fred A. Wright, Stephan M. Tanner, Bo Yuan, William J. Lemon, Michael A. Caligiuri, Clara D. Bloomfield, Albert de la Chapelle, and Ralf Krahe
Proc Natl Acad Sci U S A. 2001 January 30; 98(3): 1124–1129.
PMCID: PMC14719
Analysis of the blind Drosophila mutant ninaB identifies the gene encoding the key enzyme for vitamin A formation in vivo
Johannes von Lintig, Armin Dreher, Cornelia Kiefer, Mathias F. Wernet, and Klaus Vogt
Proc Natl Acad Sci U S A. 2001 January 30; 98(3): 1130–1135. Published online 2001 January 16.
PMCID: PMC14720
Similar regions of human chromosome 3 are eliminated from or retained in human/human and human/mouse microcell hybrids during tumor growth in severe combined immunodeficient (SCID) mice
Ying Yang, Maria Kost-Alimova, Sigurdur Ingvarsson, Qiu Qianhui, Hajnalka Kiss, Anna Szeles, Irina Kholodnyuk, Andrew Cuthbert, George Klein, and Stephan Imreh
Proc Natl Acad Sci U S A. 2001 January 30; 98(3): 1136–1141.
PMCID: PMC14721
Immunology
Genetic remodeling of protein glycosylation in vivo induces autoimmune disease
Daniel Chui, Gayathri Sellakumar, Ryan S. Green, Mark Sutton-Smith, Tammie McQuistan, Kurt W. Marek, Howard R. Morris, Anne Dell, and Jamey D. Marth
Proc Natl Acad Sci U S A. 2001 January 30; 98(3): 1142–1147.
PMCID: PMC14722
The mechanism by which a peptide based on complementarity-determining region-1 of a pathogenic anti-DNA auto-Ab ameliorates experimental systemic lupus erythematosus
Eran Eilat, Molly Dayan, Heidy Zinger, and Edna Mozes
Proc Natl Acad Sci U S A. 2001 January 30; 98(3): 1148–1153.
PMCID: PMC14723
Activated Cdc42/Rac reconstitutes Fc[var epsilon]RI-mediated Ca2+ mobilization and degranulation in mutant RBL mast cells
Elizabeth Hong-Geller, David Holowka, Reuben P. Siraganian, Barbara Baird, and Richard A. Cerione
Proc Natl Acad Sci U S A. 2001 January 30; 98(3): 1154–1159.
PMCID: PMC14724
CD8+ T cells recognize an inclusion membrane-associated protein from the vacuolar pathogen Chlamydia trachomatis
Steven P. Fling, R. Alec Sutherland, Lisa N. Steele, Bruce Hess, Sarah E. F. D'Orazio, Jean-François Maisonneuve, Mary F. Lampe, Peter Probst, and Michael N. Starnbach
Proc Natl Acad Sci U S A. 2001 January 30; 98(3): 1160–1165.
PMCID: PMC14725
CD40-CD40L independent Ig gene hypermutation suggests a second B cell diversification pathway in humans
Sandra Weller, Ahmad Faili, Corinne Garcia, Moritz C. Braun, Françoise Le Deist, Geneviève de Saint Basile, Olivier Hermine, Alain Fischer, Claude-Agnès Reynaud, and Jean-Claude Weill
Proc Natl Acad Sci U S A. 2001 January 30; 98(3): 1166–1170.
PMCID: PMC14726
Medical Sciences
Evolution of treatment effects over time: Empirical insight from recursive cumulative metaanalyses
John P. A. Ioannidis and Joseph Lau
Proc Natl Acad Sci U S A. 2001 January 30; 98(3): 831–836. Published online 2001 January 23.
PMCID: PMC14669
A cross-link breaker has sustained effects on arterial and ventricular properties in older rhesus monkeys
Peter V. Vaitkevicius, Mark Lane, Harold Spurgeon, Donald K. Ingram, George S. Roth, John J. Egan, Sara Vasan, Dilip R. Wagle, Peter Ulrich, Michael Brines, Jean Paul Wuerth, Anthony Cerami, and Edward G. Lakatta
Proc Natl Acad Sci U S A. 2001 January 30; 98(3): 1171–1175.
PMCID: PMC14727
Analysis of gene expression profiles in normal and neoplastic ovarian tissue samples identifies candidate molecular markers of epithelial ovarian cancer
John B. Welsh, Patrick P. Zarrinkar, Lisa M. Sapinoso, Suzanne G. Kern, Cynthia A. Behling, Bradley J. Monk, David J. Lockhart, Robert A. Burger, and Garret M. Hampton
Proc Natl Acad Sci U S A. 2001 January 30; 98(3): 1176–1181.
PMCID: PMC14728
From the Cover:
Polycystin-2, the protein mutated in autosomal dominant polycystic kidney disease (ADPKD), is a Ca2+-permeable nonselective cation channel
Silvia González-Perrett, Keetae Kim, Cristina Ibarra, Alicia E. Damiano, Elsa Zotta, Marisa Batelli, Peter C. Harris, Ignacio L. Reisin, M. Amin Arnaout, and Horacio F. Cantiello
Proc Natl Acad Sci U S A. 2001 January 30; 98(3): 1182–1187. Published online 2000 December 26.
PMCID: PMC14729
Regulation of p53 stability and p53-dependent apoptosis by NADH quinone oxidoreductase 1
Gad Asher, Joseph Lotem, Batya Cohen, Leo Sachs, and Yosef Shaul
Proc Natl Acad Sci U S A. 2001 January 30; 98(3): 1188–1193. Published online 2001 January 23.
PMCID: PMC14730
Lack of type XV collagen causes a skeletal myopathy and cardiovascular defects in mice
Lauri Eklund, Jarkko Piuhola, Jyrki Komulainen, Raija Sormunen, Chalermporn Ongvarrasopone, Reinhard Fässler, Anu Muona, Mika Ilves, Heikki Ruskoaho, Timo E. S. Takala, and Taina Pihlajaniemi
Proc Natl Acad Sci U S A. 2001 January 30; 98(3): 1194–1199. Published online 2001 January 23.
PMCID: PMC14731
Polymer-based gene delivery with low cytotoxicity by a unique balance of side-chain termini
David Putnam, Christine A. Gentry, Daniel W. Pack, and Robert Langer
Proc Natl Acad Sci U S A. 2001 January 30; 98(3): 1200–1205. Published online 2001 January 23.
PMCID: PMC14732
Copper-64-diacetyl-bis(N4-methylthiosemicarbazone): An agent for radiotherapy
Jason S. Lewis, Richard Laforest, Thomas L. Buettner, Sheng-Kwei Song, Yasuhisa Fujibayashi, Judith M. Connett, and Michael J. Welch
Proc Natl Acad Sci U S A. 2001 January 30; 98(3): 1206–1211.
PMCID: PMC14733
Prolonging the half-life of human interferon-α2 in circulation: Design, preparation, and analysis of (2-sulfo-9-fluorenylmethoxycarbonyl)7- interferon-α2
Yoram Shechter, Liana Preciado-Patt, Gideon Schreiber, and Mati Fridkin
Proc Natl Acad Sci U S A. 2001 January 30; 98(3): 1212–1217.
PMCID: PMC14734
Complete switch from Mdm2 to human papillomavirus E6-mediated degradation of p53 in cervical cancer cells
Arnd Hengstermann, Laetitia K. Linares, Aaron Ciechanover, Noel J. Whitaker, and Martin Scheffner
Proc Natl Acad Sci U S A. 2001 January 30; 98(3): 1218–1223. Published online 2001 January 23.
PMCID: PMC14735
Microbiology
An Epstein–Barr-related herpesvirus from marmoset lymphomas
Young-Gyu Cho, Jan Ramer, Pierre Rivailler, Carol Quink, Richard L. Garber, David R. Beier, and Fred Wang
Proc Natl Acad Sci U S A. 2001 January 30; 98(3): 1224–1229.
PMCID: PMC14736
Neurobiology
Odor-evoked calcium signals in dendrites of rat mitral cells
Serge Charpak, Jerome Mertz, Emmanuel Beaurepaire, Laurent Moreaux, and Kerry Delaney
Proc Natl Acad Sci U S A. 2001 January 30; 98(3): 1230–1234. Published online 2001 January 16.
PMCID: PMC14737
Nodes of Ranvier form in association with ezrin-radixin-moesin (ERM)-positive Schwann cell processes
Carmen V. Melendez-Vasquez, Jose C. Rios, George Zanazzi, Stephen Lambert, Anthony Bretscher, and James L. Salzer
Proc Natl Acad Sci U S A. 2001 January 30; 98(3): 1235–1240.
PMCID: PMC14738
Acetylcholine receptor channel structure in the resting, open, and desensitized states probed with the substituted-cysteine-accessibility method
Gary G. Wilson and Arthur Karlin
Proc Natl Acad Sci U S A. 2001 January 30; 98(3): 1241–1248. Published online 2001 January 16.
PMCID: PMC14739
From the Cover:
Progesterone receptor and dopamine receptors are required in Δ9-tetrahydrocannabinol modulation of sexual receptivity in female rats
Shailaja K. Mani, Andrea Mitchell, and Bert W. O'Malley
Proc Natl Acad Sci U S A. 2001 January 30; 98(3): 1249–1254. Published online 2001 January 23.
PMCID: PMC14740
Dopamine-dependent synaptic plasticity in striatum during in vivo development
Ka-Choi Tang, Malcolm J. Low, David K. Grandy, and David M. Lovinger
Proc Natl Acad Sci U S A. 2001 January 30; 98(3): 1255–1260. Published online 2001 January 16.
PMCID: PMC14741
Contribution of cytoskeleton to the internalization of AMPA receptors
Qiang Zhou, Min-Yi Xiao, and Roger A. Nicoll
Proc Natl Acad Sci U S A. 2001 January 30; 98(3): 1261–1266. Published online 2001 January 23.
PMCID: PMC14742
Cholesterol binding at the cholesterol recognition/ interaction amino acid consensus (CRAC) of the peripheral-type benzodiazepine receptor and inhibition of steroidogenesis by an HIV TAT-CRAC peptide
Hua Li, Zhi-xing Yao, Babett Degenhardt, Gary Teper, and Vassilios Papadopoulos
Proc Natl Acad Sci U S A. 2001 January 30; 98(3): 1267–1272. Published online 2001 January 23.
PMCID: PMC14743
Control of eye movements and spatial attention
Tirin Moore and Mazyar Fallah
Proc Natl Acad Sci U S A. 2001 January 30; 98(3): 1273–1276. Published online 2001 January 16.
PMCID: PMC14744
Brain serotonin dysfunction accounts for aggression in male mice lacking neuronal nitric oxide synthase
Silvana Chiavegatto, Valina L. Dawson, Laura A. Mamounas, Vassilis E. Koliatsos, Ted M. Dawson, and Randy J. Nelson
Proc Natl Acad Sci U S A. 2001 January 30; 98(3): 1277–1281. Published online 2001 January 16.
PMCID: PMC14745
What is a moment? Transient synchrony as a collective mechanism for spatiotemporal integration
J. J. Hopfield and Carlos D. Brody
Proc Natl Acad Sci U S A. 2001 January 30; 98(3): 1282–1287. Published online 2001 January 23.
PMCID: PMC14746
Pharmacology
Expression of Q227L-Gαs inhibits intimal vessel wall hyperplasia after balloon injury
Wilfred Holness, Tara A. Santore, George P. Brown, John T. Fallon, Mark B. Taubman, and Ravi Iyengar
Proc Natl Acad Sci U S A. 2001 January 30; 98(3): 1288–1293.
PMCID: PMC14747
Reduced susceptibility to ischemic brain injury and N-methyl-d-aspartate-mediated neurotoxicity in cyclooxygenase-2-deficient mice
Costantino Iadecola, Kiyoshi Niwa, Shigeru Nogawa, Xueren Zhao, Masao Nagayama, Eiichi Araki, Scott Morham, and M. Elizabeth Ross
Proc Natl Acad Sci U S A. 2001 January 30; 98(3): 1294–1299.
PMCID: PMC14748
Physiology
Regulation of cystic fibrosis transmembrane conductance regulator single-channel gating by bivalent PDZ-domain-mediated interaction
Viswanathan Raghuram, Don-On Daniel Mak, and J. Kevin Foskett
Proc Natl Acad Sci U S A. 2001 January 30; 98(3): 1300–1305. Published online 2001 January 23.
PMCID: PMC14749
Plant Biology
Parthenocarpic apple fruit production conferred by transposon insertion mutations in a MADS-box transcription factor
Jia-Long Yao, Yi-Hu Dong, and Bret A. M. Morris
Proc Natl Acad Sci U S A. 2001 January 30; 98(3): 1306–1311. Published online 2001 January 23.
PMCID: PMC14750
Psychology
N-cadherin is regulated by gonadal steroids in the adult hippocampus
Douglas A. Monks, Spiro Getsios, Colin D. MacCalman, and Neil V. Watson
Proc Natl Acad Sci U S A. 2001 January 30; 98(3): 1312–1316. Published online 2001 January 23.
PMCID: PMC14751
Corrections
Correction
Proc Natl Acad Sci U S A. 2001 January 30; 98(3): 1317. Published online 2001 January 23.
PMCID: PMC55933
Corrects: Thoralf Optiz, et al. Remodeling of α-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid receptor subunit composition in hippocampal neurons after global ischemia. Proc Natl Acad Sci U S A. 2000 November 21; 97(24): 13360–13365.
Correction
Proc Natl Acad Sci U S A. 2001 January 30; 98(3): 1317.
PMCID: PMC55934
Corrects: John McLaughlin, et al. Sparing of neuronal function postseizure with gene therapy. Proc Natl Acad Sci U S A. 2000 November 7; 97(23): 12804–12809.
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