| | This journal provides immediate access to some articles. Commentaries The jaundice of the cell David A. Greenberg PMCID: PMC138521 T cells take aim at cancer Drew Pardoll PMCID: PMC138522 Plant cell adhesion: A bioassay facilitates discovery of the first pectin biosynthetic gene Elizabeth M. Lord and Jean-Claude Mollet PMCID: PMC138523 Surfing on protein folding energy landscapes Joost W. H. Schymkowitz, Frederic Rousseau, and Luis Serrano PMCID: PMC138524 The geometry of phenotypic evolution in developmental hyperspace Jason B. Wolf PMCID: PMC138525 Biological skeletal carbonate records changes in major-ion chemistry of paleo-oceans Isabel P. Montañez PMCID: PMC138526 Mitotic chromosome scaffold structure: New approaches to an old controversy Andrew S. Belmont PMCID: PMC138527 Physical Sciences Chemistry The acquisition of multidimensional NMR spectra within a single scan Lucio Frydman, Tali Scherf, and Adonis Lupulescu PMCID: PMC138528 Secondary and tertiary structures of gaseous protein ions characterized by electron capture dissociation mass spectrometry and photofragment spectroscopy HanBin Oh, Kathrin Breuker, Siu Kwan Sze, Ying Ge, Barry K. Carpenter, and Fred W. McLafferty PMCID: PMC138529 Computer Sciences A self-organizing principle for learning nonlinear manifolds Dimitris K. Agrafiotis and Huafeng Xu PMCID: PMC138530 Geophysics Surface crystallization of supercooled water in clouds A. Tabazadeh, Y. S. Djikaev, and H. Reiss PMCID: PMC138531 Mathematics The average distances in random graphs with given expected degrees Fan Chung and Linyuan Lu PMCID: PMC138532 Sets meeting isometric copies of the lattice Z2 in exactly one point Steve Jackson and R. Daniel Mauldin PMCID: PMC138533 The Brownian Web L. R. G. Fontes, M. Isopi, C. M. Newman, and K. Ravishankar PMCID: PMC138534 Physics Information optimization in coupled audio-visual cortical maps Mehran Kardar and A. Zee PMCID: PMC138535 Biological Sciences Applied Biological Sciences Trehalose accumulation in rice plants confers high tolerance levels to different abiotic stresses Ajay K. Garg, Ju-Kon Kim, Thomas G. Owens, Anil P. Ranwala, Yang Do Choi, Leon V. Kochian, and Ray J. Wu PMCID: PMC138536 Air pollution induces heritable DNA mutations Christopher M. Somers, Carole L. Yauk, Paul A. White, Craig L. J. Parfett, and James S. Quinn PMCID: PMC138537 Biochemistry An mRNA structure that controls gene expression by binding FMN Wade C. Winkler, Smadar Cohen-Chalamish, and Ronald R. Breaker PMCID: PMC138538 Functional complementation of yeast cytosolic pyrophosphatase by bacterial and plant H+-translocating pyrophosphatases José R. Pérez-Castiñeira, Rosa L. López-Marqués, José M. Villalba, Manuel Losada, and Aurelio Serrano PMCID: PMC138539 Control of PERK eIF2α kinase activity by the endoplasmic reticulum stress-induced molecular chaperone P58IPK Wei Yan, Christopher L. Frank, Marcus J. Korth, Bryce L. Sopher, Isabel Novoa, David Ron, and Michael G. Katze PMCID: PMC138540 Combining computational and experimental screening for rapid optimization of protein properties Robert J. Hayes, Jörg Bentzien, Marie L. Ary, Marian Y. Hwang, Jonathan M. Jacinto, Jost Vielmetter, Anirban Kundu, and Bassil I. Dahiyat PMCID: PMC138541 Selenosugars are key and urinary metabolites for selenium excretion within the required to low-toxic range Yayoi Kobayashi, Yasumitsu Ogra, Kazuya Ishiwata, Hiromitsu Takayama, Norio Aimi, and Kazuo T. Suzuki PMCID: PMC138542 A putative molecular-activation switch in the transmembrane domain of erbB2 Sarel J. Fleishman, Joseph Schlessinger, and Nir Ben-Tal PMCID: PMC138543 Nitrolinoleate, a nitric oxide-derived mediator of cell function: Synthesis, characterization, and vasomotor activity Dong Gun Lim, Scott Sweeney, Allison Bloodsworth, C. Roger White, Phillip H. Chumley, N. Rama Krishna, Francisco Schopfer, Valerie B. O'Donnell, Jason P. Eiserich, and Bruce A. Freeman PMCID: PMC138544 Murine apolipoprotein serum amyloid A in solution forms a hexamer containing a central channel Limin Wang, Hilal A. Lashuel, Thomas Walz, and Wilfredo Colón PMCID: PMC138545 Artificial human telomeres from DNA nanocircle templates Ulf M. Lindström, Ravi A. Chandrasekaran, Lucian Orbai, Sandra A. Helquist, Gregory P. Miller, Emin Oroudjev, Helen G. Hansma, and Eric T. Kool PMCID: PMC138546 Structure of the extracellular domains of the human interleukin-6 receptor α-chain J. N. Varghese, R. L. Moritz, M.-Z. Lou, A. van Donkelaar, H. Ji, N. Ivancic, K. M. Branson, N. E. Hall, and R. J. Simpson PMCID: PMC138547 Crystal structure of a DNA decamer containing a cis-syn thymine dimer HaJeung Park, Kaijiang Zhang, Yingjie Ren, Sourena Nadji, Nanda Sinha, John-Stephen Taylor, and ChulHee Kang PMCID: PMC138548 Catalysis at a dinuclear [CuSMo(  O)OH] cluster in a CO dehydrogenase resolved at 1.1-Å resolution Holger Dobbek, Lothar Gremer, Reiner Kiefersauer, Robert Huber, and Ortwin Meyer PMCID: PMC138549 Homology modeling of the cation binding sites of Na+K+-ATPase Haruo Ogawa and Chikashi Toyoshima PMCID: PMC138550 AMP kinase is required for mitochondrial biogenesis in skeletal muscle in response to chronic energy deprivation Haihong Zong, Jian Ming Ren, Lawrence H. Young, Marc Pypaert, James Mu, Morris J. Birnbaum, and Gerald I. Shulman PMCID: PMC138551 Identification of specific HIV-1 reverse transcriptase contacts to the viral RNA:tRNA complex by mass spectrometry and a primary amine selective reagent Mamuka Kvaratskhelia, Jennifer T. Miller, Scott R. Budihas, Lewis K. Pannell, and Stuart F. J. Le Grice PMCID: PMC138552 Studies on the function of oligosaccharyl transferase subunits: A glycosylatable photoprobe binds to the luminal domain of Ost1p Qi Yan and William J. Lennarz PMCID: PMC138553 Role of human DNA polymerase κ as an extender in translesion synthesis Lajos Haracska, Louise Prakash, and Satya Prakash PMCID: PMC138554 The 2B domain of the Escherichia coli Rep protein is not required for DNA helicase activity Wei Cheng, Katherine M. Brendza, George H. Gauss, Sergey Korolev, Gabriel Waksman, and Timothy M. Lohman PMCID: PMC138555 Biophysics Single pilus motor forces exceed 100 pN Berenike Maier, Laura Potter, Magdalene So, Hank S. Seifert, and Michael P. Sheetz PMCID: PMC138556 Scanning surface confocal microscopy for simultaneous topographical and fluorescence imaging: Application to single virus-like particle entry into a cell J. Gorelik, A. Shevchuk, M. Ramalho, M. Elliott, C. Lei, C. F. Higgins, Max J. Lab, D. Klenerman, N. Krauzewicz, and Y. Korchev PMCID: PMC138557 Guiding neuronal growth with light A. Ehrlicher, T. Betz, B. Stuhrmann, D. Koch, V. Milner, M. G. Raizen, and J. Käs PMCID: PMC138558 Consensus-derived structural determinants of the ankyrin repeat motif Leila K. Mosavi, Daniel L. Minor, Jr., and Zheng-yu Peng PMCID: PMC138559 From the Cover:
Large-scale molecular dynamics simulations of general anesthetic effects on the ion channel in the fully hydrated membrane: The implication of molecular mechanisms of general anesthesia Pei Tang and Yan Xu PMCID: PMC138560 The directional atomic solvation energy: An atom-based potential for the assignment of protein sequences to known folds Parag Mallick, Robert Weiss, and David Eisenberg PMCID: PMC138561 Slaving: Solvent fluctuations dominate protein dynamics and functions P. W. Fenimore, H. Frauenfelder, B. H. McMahon, and F. G. Parak PMCID: PMC138562 De novo designed peptide-based amyloid fibrils Manuela López de la Paz, Kenneth Goldie, Jesús Zurdo, Emmanuel Lacroix, Christopher M. Dobson, Andreas Hoenger, and Luis Serrano PMCID: PMC138563 From the Cover:
Coordination of kinesin's two heads studied with mutant heterodimers Kuniyoshi Kaseda, Hideo Higuchi, and Keiko Hirose PMCID: PMC138564 From the Cover:
Probing the folding free energy landscape of the src-SH3 protein domain Joan-Emma Shea, José N. Onuchic, and Charles L. Brooks, III PMCID: PMC138565 Cell Biology Molecular characterization of lymphatic endothelial cells Simona Podgrabinska, Pascal Braun, Paula Velasco, Bryan Kloos, Michael S. Pepper, David G. Jackson, and Mihaela Skobe PMCID: PMC138566 Complex interactions between the laminin α4 subunit and integrins regulate endothelial cell behavior in vitro and angiogenesis in vivo Annette M. Gonzalez, Meredith Gonzales, G. Scott Herron, Usha Nagavarapu, Susan B. Hopkinson, Daisuke Tsuruta, and Jonathan C. R. Jones PMCID: PMC138567 Distinct RNA motifs are important for coactivation of steroid hormone receptors by steroid receptor RNA activator (SRA) Rainer B. Lanz, Bahram Razani, Aaron D. Goldberg, and Bert W. O'Malley PMCID: PMC138568 An N-terminal domain of Dbf4p mediates interaction with both origin recognition complex (ORC) and Rad53p and can deregulate late origin firing Bernard P. Duncker, Kenji Shimada, Monika Tsai-Pflugfelder, Philippe Pasero, and Susan M. Gasser PMCID: PMC138569 From the Cover:
Biliverdin reductase: A major physiologic cytoprotectant David E. Barañano, Mahil Rao, Christopher D. Ferris, and Solomon H. Snyder PMCID: PMC138570 The autosomal recessive hypercholesterolemia (ARH) protein interfaces directly with the clathrin-coat machinery Sanjay K. Mishra, Simon C. Watkins, and Linton M. Traub PMCID: PMC138571 Developmental Biology Growth inhibitors promote differentiation of insulin-producing tissue from embryonic stem cells Yuichi Hori, Ingrid C. Rulifson, Bernette C. Tsai, Jeremy J. Heit, John D. Cahoy, and Seung K. Kim PMCID: PMC138572 Retinaldehyde dehydrogenase 2 (RALDH2)- independent patterns of retinoic acid synthesis in the mouse embryo Karen Niederreither, Julien Vermot, Valérie Fraulob, Pierre Chambon, and Pascal Dollé PMCID: PMC138573 Ecology Persistent millennial-scale shifts in moisture regimes in western Canada during the past six millennia Brian F. Cumming, Kathleen R. Laird, Joseph R. Bennett, John P. Smol, and Anne K. Salomon PMCID: PMC138574 Evolution Conflict between nuclear and mitochondrial DNA phylogenies of a recent species radiation: What mtDNA reveals and conceals about modes of speciation in Hawaiian crickets Kerry L. Shaw PMCID: PMC138575 Large-scale comparison of intron positions among animal, plant, and fungal genes Alexei Fedorov, Amir Feisal Merican, and Walter Gilbert PMCID: PMC138576 INAUGURAL ARTICLE by a Recently Elected Academy Member: Near-neutrality in evolution of genes and gene regulation Tomoko Ohta PMCID: PMC138577 Overcredibility of molecular phylogenies obtained by Bayesian phylogenetics Yoshiyuki Suzuki, Galina V. Glazko, and Masatoshi Nei PMCID: PMC138578 Genetics Characteristic genome rearrangements in experimental evolution of Saccharomyces cerevisiae Maitreya J. Dunham, Hassan Badrane, Tracy Ferea, Julian Adams, Patrick O. Brown, Frank Rosenzweig, and David Botstein PMCID: PMC138579 Penelope retroelements from Drosophila virilis are active after transformation of Drosophila melanogaster Konstantin I. Pyatkov, Natalia G. Shostak, Elena S. Zelentsova, George T. Lyozin, Michael I. Melekhin, David J. Finnegan, Margaret G. Kidwell, and Michael B. Evgen'ev PMCID: PMC138580 Digital karyotyping Tian-Li Wang, Christine Maierhofer, Michael R. Speicher, Christoph Lengauer, Bert Vogelstein, Kenneth W. Kinzler, and Victor E. Velculescu PMCID: PMC138581 RNA interference-mediated silencing of Sod2 in Drosophila leads to early adult-onset mortality and elevated endogenous oxidative stress Kim Kirby, Jianguo Hu, Arthur J. Hilliker, and John P. Phillips PMCID: PMC138582 Immunology Adoptive T cell therapy using antigen-specific CD8+ T cell clones for the treatment of patients with metastatic melanoma: In vivo persistence, migration, and antitumor effect of transferred T cells C. Yee, J. A. Thompson, D. Byrd, S. R. Riddell, P. Roche, E. Celis, and P. D. Greenberg PMCID: PMC138583 Nonlymphoid Fas ligand in peptide-induced peripheral lymphocyte deletion Michael J. Pinkoski, Nathalie M. Droin, Tesu Lin, Laurent Genestier, Thomas A. Ferguson, and Douglas R. Green PMCID: PMC138584 Disulfide bond-mediated dimerization of HLA-G on the cell surface Jonathan E. Boyson, Robert Erskine, Mary C. Whitman, Michael Chiu, Julie M. Lau, Louise A. Koopman, Markus M. Valter, Pavla Angelisova, Václav Horejsí, and Jack L. Strominger PMCID: PMC138585 Medical Sciences Nitric oxide preferentially induces type 1 T cell differentiation by selectively up-regulating IL-12 receptor β2 expression via cGMP Wanda Niedbala, Xiao-qing Wei, Carol Campbell, Duncan Thomson, Mousa Komai-Koma, and Foo Y. Liew PMCID: PMC138586 Magnetic resonance microimaging of intraaxonal water diffusion in live excised lamprey spinal cord Masaya Takahashi, David B. Hackney, Guixin Zhang, Suzanne L. Wehrli, Alex C. Wright, William T. O'Brien, Hidemasa Uematsu, Felix W. Wehrli, and Michael E. Selzer PMCID: PMC138587 Ventricular septal defect and cardiomyopathy in mice lacking the transcription factor CHF1/Hey2 Yasuhiko Sakata, Caramai N. Kamei, Hironori Nakagami, Roderick Bronson, James K. Liao, and Michael T. Chin PMCID: PMC138588 Phospholipase A2 group IIA expression in gastric adenocarcinoma is associated with prolonged survival and less frequent metastasis Suet Y. Leung, Xin Chen, Kent M. Chu, Siu T. Yuen, Jonathan Mathy, Jiafu Ji, Annie S. Y. Chan, Rui Li, Simon Law, Olga G. Troyanskaya, I-Ping Tu, John Wong, Samuel So, David Botstein, and Patrick O. Brown PMCID: PMC138589 STAT1 deficiency unexpectedly and markedly exacerbates the pathophysiological actions of IFN-α in the central nervous system Jianping Wang, Robert D. Schreiber, and Iain L. Campbell PMCID: PMC138590 Loci on chromosomes 14 and 2, distinct from ABCG5/ABCG8, regulate plasma plant sterol levels in a C57BL/6J × CASA/Rk intercross Ephraim Sehayek, Elizabeth M. Duncan, Dieter Lutjohann, Klaus von Bergmann, Jennie G. Ono, Ashok K. Batta, Gerald Salen, and Jan L. Breslow PMCID: PMC138591 Preferential induction of apoptosis for primary human leukemic stem cells Monica L. Guzman, Carol F. Swiderski, Dianna S. Howard, Barry A. Grimes, Randall M. Rossi, Stephen J. Szilvassy, and Craig T. Jordan PMCID: PMC138592 The role of chromosomal instability in tumor initiation Martin A. Nowak, Natalia L. Komarova, Anirvan Sengupta, Prasad V. Jallepalli, Ie-Ming Shih, Bert Vogelstein, and Christoph Lengauer PMCID: PMC138593 Immunization and immunotherapy for cancers involving infection by a human papillomavirus in a mouse model Jin Li, Ying Sun, and Alan Garen PMCID: PMC138594 Disruption of Abcg5 and Abcg8 in mice reveals their crucial role in biliary cholesterol secretion Liqing Yu, Robert E. Hammer, Jia Li-Hawkins, Klaus von Bergmann, Dieter Lutjohann, Jonathan C. Cohen, and Helen H. Hobbs PMCID: PMC138595 Microbiology The membrane protein FeoB contains an intramolecular G protein essential for Fe(II) uptake in bacteria Thomas C. Marlovits, Winfried Haase, Christian Herrmann, Stephen G. Aller, and Vinzenz M. Unger PMCID: PMC138596 Sensitivity of HIV-1 to entry inhibitors correlates with envelope/coreceptor affinity, receptor density, and fusion kinetics Jacqueline D. Reeves, Stephen A. Gallo, Navid Ahmad, John L. Miamidian, Phoebe E. Harvey, Matthew Sharron, Stefan Pöhlmann, Jeffrey N. Sfakianos, Cynthia A. Derdeyn, Robert Blumenthal, Eric Hunter, and Robert W. Doms PMCID: PMC138597 Human cytomegalovirus gene expression during infection of primary hematopoietic progenitor cells: A model for latency Felicia D. Goodrum, Craig T. Jordan, Kevin High, and Thomas Shenk PMCID: PMC138598 Neuroscience The spatial receptive field of thalamic inputs to single cortical simple cells revealed by the interaction of visual and electrical stimulation Prakash Kara, John S. Pezaris, Sergey Yurgenson, and R. Clay Reid PMCID: PMC138599 Monitoring of implanted stem cell migration in vivo: A highly resolved in vivo magnetic resonance imaging investigation of experimental stroke in rat Mathias Hoehn, Ekkehard Küstermann, James Blunk, Dirk Wiedermann, Thorsten Trapp, Stefan Wecker, Melanie Föcking, Heinz Arnold, Jürgen Hescheler, Bernd K. Fleischmann, Wolfram Schwindt, and Christian Bührle PMCID: PMC138600 Differential modulation of BMP signaling promotes the elaboration of cerebral cortical GABAergic neurons or oligodendrocytes from a common sonic hedgehog-responsive ventral forebrain progenitor species Shau-Yu Yung, Solen Gokhan, Jennifer Jurcsak, Aldrin E. Molero, Joseph J. Abrajano, and Mark F. Mehler PMCID: PMC138601 Memory-specific temporal profiles of gene expression in the hippocampus Sebastiano Cavallaro, Velia D'Agata, Pachiappan Manickam, Franck Dufour, and Daniel L. Alkon PMCID: PMC138602 Prion and doppel proteins bind to granule cells of the cerebellum Giuseppe Legname, Peter Nelken, Zhengyu Guan, Zoltan F. Kanyo, Stephen J. DeArmond, and Stanley B. Prusiner PMCID: PMC138603 Hypothalamic gene expression in reproductively photoresponsive and photorefractory Siberian hamsters Brian J. Prendergast, Bedrich Mosinger, Jr., Pappachan E. Kolattukudy, and Randy J. Nelson PMCID: PMC138604 Molecular basis of cell migration in the fish lateral line: Role of the chemokine receptor CXCR4 and of its ligand, SDF1 Nicolas B. David, Dora Sapède, Laure Saint-Etienne, Christine Thisse, Bernard Thisse, Christine Dambly-Chaudière, Frédéric M. Rosa, and Alain Ghysen PMCID: PMC138605 Therapeutic intervention in experimental allergic encephalomyelitis by administration of uric acid precursors Gwen S. Scott, Sergei V. Spitsin, Rhonda B. Kean, Tatiana Mikheeva, Hilary Koprowski, and D. Craig Hooper PMCID: PMC138606 Physiology Enhanced muscle fat oxidation and glucose transport by ACRP30 globular domain: Acetyl–CoA carboxylase inhibition and AMP-activated protein kinase activation Eva Tomas, Tsu-Shuen Tsao, Asish K. Saha, Heather E. Murrey, Cheng cheng Zhang, Samar I. Itani, Harvey F. Lodish, and Neil B. Ruderman PMCID: PMC138607 Plant Biology A new role for an old enzyme: Nitrate reductase-mediated nitric oxide generation is required for abscisic acid-induced stomatal closure in Arabidopsis thaliana Radhika Desikan, Rachael Griffiths, John Hancock, and Steven Neill PMCID: PMC138608 From the Cover:
A pectin glucuronyltransferase gene is essential for intercellular attachment in the plant meristem Hiroaki Iwai, Nobutaka Masaoka, Tadashi Ishii, and Shinobu Satoh PMCID: PMC138609 Transgenic barley grain overexpressing thioredoxin shows evidence that the starchy endosperm communicates with the embryo and the aleurone Joshua H. Wong, Yong-Bum Kim, Pei-Hsien Ren, Nick Cai, Myeong-Je Cho, Peter Hedden, Peggy G. Lemaux, and Bob B. Buchanan PMCID: PMC138610 In vitro reconstitution of the activated zeaxanthin state associated with energy dissipation in plants Mark Aspinall-O'Dea, Mark Wentworth, Andy Pascal, Bruno Robert, Alexander Ruban, and Peter Horton PMCID: PMC138611 AGAMOUS-LIKE 24, a dosage-dependent mediator of the flowering signals Hao Yu, Yifeng Xu, Ee Ling Tan, and Prakash P. Kumar PMCID: PMC138612 A subclass of plant heat shock cognate 70 chaperones carries a motif that facilitates trafficking through plasmodesmata Koh Aoki, Friedrich Kragler, Beatriz Xoconostle-Cázares, and William J. Lucas PMCID: PMC138613 Population Biology Mosaic organization and heterogeneity in frequency of allelic recombination of the Plasmodium vivax merozoite surface protein-1 locus Chaturong Putaporntip, Somchai Jongwutiwes, Naoko Sakihama, Marcelo U. Ferreira, Weon-Gyu Kho, Akira Kaneko, Hiroji Kanbara, Tetsuya Hattori, and Kazuyuki Tanabe PMCID: PMC138614 Psychology (Biological Sciences) Dissociation between conflict detection and error monitoring in the human anterior cingulate cortex Diane Swick and And U. Turken PMCID: PMC138615 Social Sciences Anthropology African rice (Oryza glaberrima): History and future potential Olga F. Linares PMCID: PMC138616 Psychology Attentional mechanisms of borderline personality disorder Michael I. Posner, Mary K. Rothbart, Nathalie Vizueta, Kenneth N. Levy, David E. Evans, Kathleen M. Thomas, and John F. Clarkin PMCID: PMC138617 Visual detection is gated by attending for action: Evidence from hemispatial neglect Robert Rafal, Shai Danziger, Giordana Grossi, Liana Machado, and Robert Ward PMCID: PMC138618 Correction Proc Natl Acad Sci U S A. 2002 December 10; 99(25): 16376. Published online 2002 November 26. doi: 10.1073/pnas.252641499.PMCID: PMC138520 Corrects: F. Kent Hamra, et al. Production of transgenic rats by lentiviral transduction of male germ-line stem cells. Proc Natl Acad Sci U S A. 2002 November 12; 99(23): 14931–14936. |
