| | This journal provides immediate access to some articles. Commentaries A copper connection to the uptake of platinum anticancer drugs John L. Nitiss Proc Natl Acad Sci U S A. 2002 October 29; 99(22): 13963–13965. Published online 2002 October 21. doi: 10.1073/pnas.232574299.PMCID: PMC137818 The inner inner core of Earth Don L. Anderson Proc Natl Acad Sci U S A. 2002 October 29; 99(22): 13966–13968. Published online 2002 October 21. doi: 10.1073/pnas.232565899.PMCID: PMC137819 New careers for antioxidants Douglas E. Brash and P. A. Havre Proc Natl Acad Sci U S A. 2002 October 29; 99(22): 13969–13971. Published online 2002 October 21. doi: 10.1073/pnas.232574399.PMCID: PMC137820 Etiology of Parkinson's disease: Genetics and environment revisited Kathy Steece-Collier, Eleonora Maries, and Jeffrey H. Kordower Proc Natl Acad Sci U S A. 2002 October 29; 99(22): 13972–13974. Published online 2002 October 21. doi: 10.1073/pnas.242594999.PMCID: PMC137821 Physical Sciences Applied Mathematics Near strongly resonant periodic orbits in a Hamiltonian system Vassili Gelfreich Proc Natl Acad Sci U S A. 2002 October 29; 99(22): 13975–13979. Published online 2002 October 21. doi: 10.1073/pnas.212116699.PMCID: PMC137822 INAUGURAL ARTICLE by a Recently Elected Academy Member: Distributional regimes for the number of k-word matches between two random sequences Ross A. Lippert, Haiyan Huang, and Michael S. Waterman Proc Natl Acad Sci U S A. 2002 October 29; 99(22): 13980–13989. Published online 2002 October 8. doi: 10.1073/pnas.202468099.PMCID: PMC137823 Applied Physical Sciences Neurotoxic effects of thioflavin S-positive amyloid deposits in transgenic mice and Alzheimer's disease B. Urbanc, L. Cruz, R. Le, J. Sanders, K. Hsiao Ashe, K. Duff, H. E. Stanley, M. C. Irizarry, and B. T. Hyman Proc Natl Acad Sci U S A. 2002 October 29; 99(22): 13990–13995. Published online 2002 October 9. doi: 10.1073/pnas.222433299.PMCID: PMC137824 Chemistry Bioactive alkaloids of frog skin: Combinatorial bioprospecting reveals that pumiliotoxins have an arthropod source John W. Daly, Tetsuo Kaneko, Jason Wilham, H. Martin Garraffo, Thomas F. Spande, Alex Espinosa, and Maureen A. Donnelly Proc Natl Acad Sci U S A. 2002 October 29; 99(22): 13996–14001. Published online 2002 October 14. doi: 10.1073/pnas.222551599.PMCID: PMC137825 A polyketide synthase-peptide synthetase gene cluster from an uncultured bacterial symbiont of Paederus beetles Jörn Piel Proc Natl Acad Sci U S A. 2002 October 29; 99(22): 14002–14007. Published online 2002 October 14. doi: 10.1073/pnas.222481399.PMCID: PMC137826 Biodirected epitaxial nanodeposition of polymers on oriented macromolecular templates Tetsuo Kondo, Masanobu Nojiri, Yukako Hishikawa, Eiji Togawa, Dwight Romanovicz, and R. Malcolm Brown, Jr. Proc Natl Acad Sci U S A. 2002 October 29; 99(22): 14008–14013. Published online 2002 October 10. doi: 10.1073/pnas.212238399.PMCID: PMC137827 Computer Sciences Growing and navigating the small world Web by local content Filippo Menczer Proc Natl Acad Sci U S A. 2002 October 29; 99(22): 14014–14019. Published online 2002 October 14. doi: 10.1073/pnas.212348399.PMCID: PMC137828 Geophysics From the Cover: The Cretaceous superchron geodynamo: Observations near the tangent cylinder John A. Tarduno, Rory D. Cottrell, and Alexei V. Smirnov Proc Natl Acad Sci U S A. 2002 October 29; 99(22): 14020–14025. Published online 2002 October 18. doi: 10.1073/pnas.222373499.PMCID: PMC137829 From the Cover: The innermost inner core of the earth: Evidence for a change in anisotropic behavior at the radius of about 300 km Miaki Ishii and Adam M. Dziewoński Proc Natl Acad Sci U S A. 2002 October 29; 99(22): 14026–14030. Published online 2002 October 8. doi: 10.1073/pnas.172508499.PMCID: PMC137830 Physics Estimating physical reflectance spectra from human color-matching experiments A. Kimball Romney and Tarow Indow Proc Natl Acad Sci U S A. 2002 October 29; 99(22): 14607–14610. Published online 2002 October 18. doi: 10.1073/pnas.222558899.PMCID: PMC137930 Statistics Quantitative noise analysis for gene expression microarray experiments Y. Tu, G. Stolovitzky, and U. Klein Proc Natl Acad Sci U S A. 2002 October 29; 99(22): 14031–14036. Published online 2002 October 18. doi: 10.1073/pnas.222164199.PMCID: PMC137831 Biological Sciences Biochemistry An approach to membrane protein structure without crystals Paul L. Sorgen, Yonglin Hu, Lan Guan, H. Ronald Kaback, and Mark E. Girvin Proc Natl Acad Sci U S A. 2002 October 29; 99(22): 14037–14040. Published online 2002 October 21. doi: 10.1073/pnas.182552199.PMCID: PMC137832 Crystal structure of the DNA-binding domain from Ndt80, a transcriptional activator required for meiosis in yeast Sherwin P. Montano, Marie L. Coté, Ian Fingerman, Michael Pierce, Andrew K. Vershon, and Millie M. Georgiadis Proc Natl Acad Sci U S A. 2002 October 29; 99(22): 14041–14046. Published online 2002 October 16. doi: 10.1073/pnas.222312199.PMCID: PMC137833 A nucleolar TAR decoy inhibitor of HIV-1 replication Alessandro Michienzi, Shirley Li, John A. Zaia, and John J. Rossi Proc Natl Acad Sci U S A. 2002 October 29; 99(22): 14047–14052. Published online 2002 October 10. doi: 10.1073/pnas.212229599.PMCID: PMC137834 Structure of a regulatory complex involving the Abl SH3 domain, the Crk SH2 domain, and a Crk-derived phosphopeptide Logan W. Donaldson, Gerald Gish, Tony Pawson, Lewis E. Kay, and Julie D. Forman-Kay Proc Natl Acad Sci U S A. 2002 October 29; 99(22): 14053–14058. Published online 2002 October 16. doi: 10.1073/pnas.212518799.PMCID: PMC137835 Three-dimensional model of the human platelet integrin αIIbβ3 based on electron cryomicroscopy and x-ray crystallography Brian D. Adair and Mark Yeager Proc Natl Acad Sci U S A. 2002 October 29; 99(22): 14059–14064. Published online 2002 October 18. doi: 10.1073/pnas.212498199.PMCID: PMC137836 Structure of the GCN5 histone acetyltransferase bound to a bisubstrate inhibitor Arienne N. Poux, Marek Cebrat, Cheol M. Kim, Philip A. Cole, and Ronen Marmorstein Proc Natl Acad Sci U S A. 2002 October 29; 99(22): 14065–14070. Published online 2002 October 21. doi: 10.1073/pnas.222373899.PMCID: PMC137837 Small molecule modulation of Smoothened activity James K. Chen, Jussi Taipale, Keith E. Young, Tapan Maiti, and Philip A. Beachy Proc Natl Acad Sci U S A. 2002 October 29; 99(22): 14071–14076. Published online 2002 October 21. doi: 10.1073/pnas.182542899.PMCID: PMC137838 Promiscuity in ligand-binding: The three-dimensional structure of a Piromyces carbohydrate-binding module, CBM29-2, in complex with cello- and mannohexaose Simon J. Charnock, David N. Bolam, Didier Nurizzo, Lóránd Szabó, Vincent A. McKie, Harry J. Gilbert, and Gideon J. Davies Proc Natl Acad Sci U S A. 2002 October 29; 99(22): 14077–14082. Published online 2002 October 21. doi: 10.1073/pnas.212516199.PMCID: PMC137839 Regeneration of misprimed nonribosomal peptide synthetases by type II thioesterases Dirk Schwarzer, Henning D. Mootz, Uwe Linne, and Mohamed A. Marahiel Proc Natl Acad Sci U S A. 2002 October 29; 99(22): 14083–14088. Published online 2002 October 16. doi: 10.1073/pnas.212382199.PMCID: PMC137840 Does RNA polymerase help drive chromosome segregation in bacteria? Jonathan Dworkin and Richard Losick Proc Natl Acad Sci U S A. 2002 October 29; 99(22): 14089–14094. Published online 2002 October 16. doi: 10.1073/pnas.182539899.PMCID: PMC137841 ![[var phi]](corehtml/pmc/pmcents/x03C6.gif) value analysis of heterogeneity in pathways of allosteric transitions: Evidence for parallel pathways of ATP-induced conformational changes in a GroEL ring Amnon Horovitz, Amnon Amir, Oded Danziger, and Galit Kafri Proc Natl Acad Sci U S A. 2002 October 29; 99(22): 14095–14097. Published online 2002 October 18. doi: 10.1073/pnas.222303299.PMCID: PMC137842 Bacterial redox protein azurin, tumor suppressor protein p53, and regression of cancer Tohru Yamada, Masatoshi Goto, Vasu Punj, Olga Zaborina, Mei Ling Chen, Kazuhide Kimbara, Dibyen Majumdar, Elizabeth Cunningham, Tapas K. Das Gupta, and Ananda M. Chakrabarty Proc Natl Acad Sci U S A. 2002 October 29; 99(22): 14098–14103. Published online 2002 October 22. doi: 10.1073/pnas.222539699.PMCID: PMC137843 Tubulin is the endogenous inhibitor of the glyceraldehyde 3-phosphate dehydrogenase isoform that catalyzes membrane fusion: Implications for the coordinated regulation of glycolysis and membrane fusion Paul E. Glaser, Xianlin Han, and Richard W. Gross Proc Natl Acad Sci U S A. 2002 October 29; 99(22): 14104–14109. Published online 2002 October 15. doi: 10.1073/pnas.222542999.PMCID: PMC137844 Biophysics Pairs of dipeptides synergistically activate the binding of substrate by ubiquitin ligase through dissociation of its autoinhibitory domain Fangyong Du, Federico Navarro-Garcia, Zanxian Xia, Takafumi Tasaki, and Alexander Varshavsky Proc Natl Acad Sci U S A. 2002 October 29; 99(22): 14110–14115. Published online 2002 October 21. doi: 10.1073/pnas.172527399.PMCID: PMC137845 A simple physical model for binding energy hot spots in protein–protein complexes Tanja Kortemme and David Baker Proc Natl Acad Sci U S A. 2002 October 29; 99(22): 14116–14121. Published online 2002 October 15. doi: 10.1073/pnas.202485799.PMCID: PMC137846 On the simulation of protein folding by short time scale molecular dynamics and distributed computing Alan R. Fersht Proc Natl Acad Sci U S A. 2002 October 29; 99(22): 14122–14125. Published online 2002 October 18. doi: 10.1073/pnas.182542699.PMCID: PMC137847 Stabilities and conformations of Alzheimer's β-amyloid peptide oligomers (Aβ16–22, Aβ16–35, and Aβ10–35): Sequence effects Buyong Ma and Ruth Nussinov Proc Natl Acad Sci U S A. 2002 October 29; 99(22): 14126–14131. Published online 2002 October 21. doi: 10.1073/pnas.212206899.PMCID: PMC137848 Expanding protein universe and its origin from the biological Big Bang Nikolay V. Dokholyan, Boris Shakhnovich, and Eugene I. Shakhnovich Proc Natl Acad Sci U S A. 2002 October 29; 99(22): 14132–14136. Published online 2002 October 16. doi: 10.1073/pnas.202497999.PMCID: PMC137849 Common features in structures and sequences of sandwich-like proteins Alexander E. Kister, Alexei V. Finkelstein, and Israel M. Gelfand Proc Natl Acad Sci U S A. 2002 October 29; 99(22): 14137–14141. Published online 2002 October 16. doi: 10.1073/pnas.212511499.PMCID: PMC137850 Electronic detection of DNA by its intrinsic molecular charge Jürgen Fritz, Emily B. Cooper, Suzanne Gaudet, Peter K. Sorger, and Scott R. Manalis Proc Natl Acad Sci U S A. 2002 October 29; 99(22): 14142–14146. Published online 2002 October 17. doi: 10.1073/pnas.232276699.PMCID: PMC137851 Molecular topography imaging by intermembrane fluorescence resonance energy transfer Amy P. Wong and Jay T. Groves Proc Natl Acad Sci U S A. 2002 October 29; 99(22): 14147–14152. Published online 2002 October 21. doi: 10.1073/pnas.212392599.PMCID: PMC137852 Identification of macromolecular complexes in cryoelectron tomograms of phantom cells Achilleas S. Frangakis, Jochen Böhm, Friedrich Förster, Stephan Nickell, Daniela Nicastro, Dieter Typke, Reiner Hegerl, and Wolfgang Baumeister Proc Natl Acad Sci U S A. 2002 October 29; 99(22): 14153–14158. Published online 2002 October 21. doi: 10.1073/pnas.172520299.PMCID: PMC137853 Role of the lever arm in the processive stepping of myosin V Thomas J. Purcell, Carl Morris, James A. Spudich, and H. Lee Sweeney Proc Natl Acad Sci U S A. 2002 October 29; 99(22): 14159–14164. Published online 2002 October 17. doi: 10.1073/pnas.182539599.PMCID: PMC137854 Effect of polyethylene glycol on the liquid–liquid phase transition in aqueous protein solutions Onofrio Annunziata, Neer Asherie, Aleksey Lomakin, Jayanti Pande, Olutayo Ogun, and George B. Benedek Proc Natl Acad Sci U S A. 2002 October 29; 99(22): 14165–14170. Published online 2002 October 21. doi: 10.1073/pnas.212507199.PMCID: PMC137855 Measurement of microsecond dynamic motion in the intestinal fatty acid binding protein by using fluorescence correlation spectroscopy Krishnananda Chattopadhyay, Saveez Saffarian, Elliot L. Elson, and Carl Frieden Proc Natl Acad Sci U S A. 2002 October 29; 99(22): 14171–14176. Published online 2002 October 15. doi: 10.1073/pnas.172524899.PMCID: PMC137856 Cell Biology Glucose is toxic to glycosome-deficient trypanosomes Tetsuya Furuya, Peter Kessler, Armando Jardim, Achim Schnaufer, Christopher Crudder, and Marilyn Parsons Proc Natl Acad Sci U S A. 2002 October 29; 99(22): 14177–14182. Published online 2002 October 17. doi: 10.1073/pnas.222454899.PMCID: PMC137857 Cell surface polarization during yeast mating Michel Bagnat and Kai Simons Proc Natl Acad Sci U S A. 2002 October 29; 99(22): 14183–14188. Published online 2002 October 8. doi: 10.1073/pnas.172517799.PMCID: PMC137858 JLP: A scaffolding protein that tethers JNK/p38MAPK signaling modules and transcription factors Clement M. Lee, Djamila Onésime, C. Damodara Reddy, N. Dhanasekaran, and E. Premkumar Reddy Proc Natl Acad Sci U S A. 2002 October 29; 99(22): 14189–14194. Published online 2002 October 21. doi: 10.1073/pnas.232310199.PMCID: PMC137859 Karyopherin β2B participates in mRNA export from the nucleus Monee K. Shamsher, Jonathan Ploski, and Aurelian Radu Proc Natl Acad Sci U S A. 2002 October 29; 99(22): 14195–14199. Published online 2002 October 16. doi: 10.1073/pnas.212518199.PMCID: PMC137860 RB activation defect in tumor cell lines Cristina Broceño, Scott Wilkie, and Sibylle Mittnacht Proc Natl Acad Sci U S A. 2002 October 29; 99(22): 14200–14205. Published online 2002 October 11. doi: 10.1073/pnas.212519499.PMCID: PMC137861 Inositol pyrophosphates regulate endocytic trafficking Adolfo Saiardi, Catherine Sciambi, J. Michael McCaffery, Beverly Wendland, and Solomon H. Snyder Proc Natl Acad Sci U S A. 2002 October 29; 99(22): 14206–14211. Published online 2002 October 21. doi: 10.1073/pnas.212527899.PMCID: PMC137862 Identification of a negative response element in the human inducible nitric-oxide synthase (hiNOS) promoter: The role of NF-κB-repressing factor (NRF) in basal repression of the hiNOS gene Xuesheng Feng, Zhong Guo, Mahtab Nourbakhsh, Hansjorg Hauser, Ray Ganster, Lifang Shao, and David A. Geller Proc Natl Acad Sci U S A. 2002 October 29; 99(22): 14212–14217. Published online 2002 October 15. doi: 10.1073/pnas.212306199.PMCID: PMC137863 Developmental Biology The SQV-1 UDP-glucuronic acid decarboxylase and the SQV-7 nucleotide-sugar transporter may act in the Golgi apparatus to affect Caenorhabditis elegans vulval morphogenesis and embryonic development Ho-Yon Hwang and H. Robert Horvitz Proc Natl Acad Sci U S A. 2002 October 29; 99(22): 14218–14223. Published online 2002 October 21. doi: 10.1073/pnas.172522199.PMCID: PMC137864 The Caenorhabditis elegans vulval morphogenesis gene sqv-4 encodes a UDP-glucose dehydrogenase that is temporally and spatially regulated Ho-Yon Hwang and H. Robert Horvitz Proc Natl Acad Sci U S A. 2002 October 29; 99(22): 14224–14229. Published online 2002 October 21. doi: 10.1073/pnas.172522499.PMCID: PMC137865 Efficient production by sperm-mediated gene transfer of human decay accelerating factor (hDAF) transgenic pigs for xenotransplantation Marialuisa Lavitrano, Maria Laura Bacci, Monica Forni, Davide Lazzereschi, Carla Di Stefano, Daniela Fioretti, Paola Giancotti, Gabriella Marfé, Loredana Pucci, Luigina Renzi, Hongjun Wang, Antonella Stoppacciaro, Giorgio Stassi, Massimo Sargiacomo, Paola Sinibaldi, Valeria Turchi, Roberto Giovannoni, Giacinto Della Casa, Eraldo Seren, and Giancarlo Rossi Proc Natl Acad Sci U S A. 2002 October 29; 99(22): 14230–14235. Published online 2002 October 22. doi: 10.1073/pnas.222550299.PMCID: PMC137866 Tissue-specific RNA interference in postimplantation mouse embryos with endoribonuclease-prepared short interfering RNA Federico Calegari, Wulf Haubensak, Dun Yang, Wieland B. Huttner, and Frank Buchholz Proc Natl Acad Sci U S A. 2002 October 29; 99(22): 14236–14240. Published online 2002 October 21. doi: 10.1073/pnas.192559699.PMCID: PMC137867 The signaling domain of the erythropoietin receptor rescues prolactin receptor-mutant mammary epithelium Cathrin Brisken, Merav Socolovsky, Harvey F. Lodish, and Robert Weinberg Proc Natl Acad Sci U S A. 2002 October 29; 99(22): 14241–14245. Published online 2002 October 15. doi: 10.1073/pnas.222549599.PMCID: PMC137868 Ecology Bioactive alkaloids of frog skin: Combinatorial bioprospecting reveals that pumiliotoxins have an arthropod source John W. Daly, Tetsuo Kaneko, Jason Wilham, H. Martin Garraffo, Thomas F. Spande, Alex Espinosa, and Maureen A. Donnelly Proc Natl Acad Sci U S A. 2002 October 29; 99(22): 13996–14001. Published online 2002 October 14. doi: 10.1073/pnas.222551599.PMCID: PMC137825 A polyketide synthase-peptide synthetase gene cluster from an uncultured bacterial symbiont of Paederus beetles Jörn Piel Proc Natl Acad Sci U S A. 2002 October 29; 99(22): 14002–14007. Published online 2002 October 14. doi: 10.1073/pnas.222481399.PMCID: PMC137826 Interactions of climate change with biological invasions and land use in the Hawaiian Islands: Modeling the fate of endemic birds using a geographic information system Tracy L. Benning, Dennis LaPointe, Carter T. Atkinson, and Peter M. Vitousek Proc Natl Acad Sci U S A. 2002 October 29; 99(22): 14246–14249. Published online 2002 October 8. doi: 10.1073/pnas.162372399.PMCID: PMC137869 Genomic analysis of uncultured marine viral communities Mya Breitbart, Peter Salamon, Bjarne Andresen, Joseph M. Mahaffy, Anca M. Segall, David Mead, Farooq Azam, and Forest Rohwer Proc Natl Acad Sci U S A. 2002 October 29; 99(22): 14250–14255. Published online 2002 October 16. doi: 10.1073/pnas.202488399.PMCID: PMC137870 Carbon emissions from tropical deforestation and regrowth based on satellite observations for the 1980s and 1990s Ruth S. DeFries, Richard A. Houghton, Matthew C. Hansen, Christopher B. Field, David Skole, and John Townshend Proc Natl Acad Sci U S A. 2002 October 29; 99(22): 14256–14261. Published online 2002 October 16. doi: 10.1073/pnas.182560099.PMCID: PMC137871 Evolution Expanding protein universe and its origin from the biological Big Bang Nikolay V. Dokholyan, Boris Shakhnovich, and Eugene I. Shakhnovich Proc Natl Acad Sci U S A. 2002 October 29; 99(22): 14132–14136. Published online 2002 October 16. doi: 10.1073/pnas.202497999.PMCID: PMC137849 Modularity, individuality, and evo-devo in butterfly wings Patrícia Beldade, Kees Koops, and Paul M. Brakefield Proc Natl Acad Sci U S A. 2002 October 29; 99(22): 14262–14267. Published online 2002 October 21. doi: 10.1073/pnas.222236199.PMCID: PMC137872 Solving the freeloaders paradox: Genetic associations and frequency-dependent selection in the evolution of cooperation among nonrelatives Leticia Avilés Proc Natl Acad Sci U S A. 2002 October 29; 99(22): 14268–14273. Published online 2002 October 14. doi: 10.1073/pnas.212408299.PMCID: PMC137873 Experimental evolution of learning ability in fruit flies Frederic Mery and Tadeusz J. Kawecki Proc Natl Acad Sci U S A. 2002 October 29; 99(22): 14274–14279. Published online 2002 October 21. doi: 10.1073/pnas.222371199.PMCID: PMC137874 Genome fragment of Wolbachia endosymbiont transferred to X chromosome of host insect Natsuko Kondo, Naruo Nikoh, Nobuyuki Ijichi, Masakazu Shimada, and Takema Fukatsu Proc Natl Acad Sci U S A. 2002 October 29; 99(22): 14280–14285. Published online 2002 October 17. doi: 10.1073/pnas.222228199.PMCID: PMC137875 A test of evolutionary theories of aging Kimberly A. Hughes, Julie A. Alipaz, Jenny M. Drnevich, and Rose M. Reynolds Proc Natl Acad Sci U S A. 2002 October 29; 99(22): 14286–14291. Published online 2002 October 17. doi: 10.1073/pnas.222326199.PMCID: PMC137876 Molecular evidence of HIV-1 transmission in a criminal case Michael L. Metzker, David P. Mindell, Xiao-Mei Liu, Roger G. Ptak, Richard A. Gibbs, and David M. Hillis Proc Natl Acad Sci U S A. 2002 October 29; 99(22): 14292–14297. Published online 2002 October 18. doi: 10.1073/pnas.222522599.PMCID: PMC137877 Genetics From the Cover: Uptake of the anticancer drug cisplatin mediated by the copper transporter Ctr1 in yeast and mammals Seiko Ishida, Jaekwon Lee, Dennis J. Thiele, and Ira Herskowitz Proc Natl Acad Sci U S A. 2002 October 29; 99(22): 14298–14302. Published online 2002 October 7. doi: 10.1073/pnas.162491399.PMCID: PMC137878 The osteopetrotic mutation toothless (tl) is a loss-of-function frameshift mutation in the rat Csf1 gene: Evidence of a crucial role for CSF-1 in osteoclastogenesis and endochondral ossification Liesbeth Van Wesenbeeck, Paul R. Odgren, Carole A. MacKay, Marina D'Angelo, Fayez F. Safadi, Steven N. Popoff, Wim Van Hul, and Sandy C. Marks, Jr. Proc Natl Acad Sci U S A. 2002 October 29; 99(22): 14303–14308. Published online 2002 October 11. doi: 10.1073/pnas.202332999.PMCID: PMC137879 Hematopoietic-specific activators establish an overlapping pattern of histone acetylation and methylation within a mammalian chromatin domain Carol M. Kiekhaefer, Jeffrey A. Grass, Kirby D. Johnson, Meghan E. Boyer, and Emery H. Bresnick Proc Natl Acad Sci U S A. 2002 October 29; 99(22): 14309–14314. Published online 2002 October 11. doi: 10.1073/pnas.212389499.PMCID: PMC137880 Functional characterization and immunolocalization of the transporter encoded by the life-extending gene Indy Felix Knauf, Blanka Rogina, Zhirong Jiang, Peter S. Aronson, and Stephen L. Helfand Proc Natl Acad Sci U S A. 2002 October 29; 99(22): 14315–14319. Published online 2002 October 21. doi: 10.1073/pnas.222531899.PMCID: PMC137881 Ssdp proteins interact with the LIM-domain-binding protein Ldb1 to regulate development Lan Chen, Daniel Segal, Neil A. Hukriede, Alexandre V. Podtelejnikov, Dashzeveg Bayarsaihan, James A. Kennison, Vasily V. Ogryzko, Igor B. Dawid, and Heiner Westphal Proc Natl Acad Sci U S A. 2002 October 29; 99(22): 14320–14325. Published online 2002 October 15. doi: 10.1073/pnas.212532399.PMCID: PMC137882 A computational/functional genomics approach for the enrichment of the retinal transcriptome and the identification of positional candidate retinopathy genes Nicholas Katsanis, Kim C. Worley, Guillermo Gonzalez, Stephen J. Ansley, and James R. Lupski Proc Natl Acad Sci U S A. 2002 October 29; 99(22): 14326–14331. Published online 2002 October 21. doi: 10.1073/pnas.222409099.PMCID: PMC137883 Heterochromatin protein 2 (HP2), a partner of HP1 in Drosophila heterochromatin Christopher D. Shaffer, Gena E. Stephens, Brandi A. Thompson, Levi Funches, John A. Bernat, Carolyn A. Craig, and Sarah C. R. Elgin Proc Natl Acad Sci U S A. 2002 October 29; 99(22): 14332–14337. Published online 2002 October 10. doi: 10.1073/pnas.212458899.PMCID: PMC137884 Immunology Protection of the intestinal mucosa by intraepithelial γδ T cells Yaping Chen, Kevin Chou, Elaine Fuchs, Wendy L. Havran, and Richard Boismenu Proc Natl Acad Sci U S A. 2002 October 29; 99(22): 14338–14343. Published online 2002 October 10. doi: 10.1073/pnas.212290499.PMCID: PMC137885 PI31 is a modulator of proteasome formation and antigen processing Dietmar M. W. Zaiss, Sybille Standera, Peter-M. Kloetzel, and Alice J. A. M. Sijts Proc Natl Acad Sci U S A. 2002 October 29; 99(22): 14344–14349. Published online 2002 October 8. doi: 10.1073/pnas.212257299.PMCID: PMC137886 Isolation and characterization of lymphocyte-like cells from a lamprey Werner E. Mayer, Tatiana Uinuk-ool, Herbert Tichy, Lanier A. Gartland, Jan Klein, and Max D. Cooper Proc Natl Acad Sci U S A. 2002 October 29; 99(22): 14350–14355. Published online 2002 October 18. doi: 10.1073/pnas.212527499.PMCID: PMC137887 Lamprey lymphocyte-like cells express homologs of genes involved in immunologically relevant activities of mammalian lymphocytes Tatiana Uinuk-ool, Werner E. Mayer, Akie Sato, Roman Dongak, Max D. Cooper, and Jan Klein Proc Natl Acad Sci U S A. 2002 October 29; 99(22): 14356–14361. Published online 2002 October 21. doi: 10.1073/pnas.212527699.PMCID: PMC137888 Glycosaminoglycans are a potential cause of rheumatoid arthritis Julia Y. Wang and Michael H. Roehrl Proc Natl Acad Sci U S A. 2002 October 29; 99(22): 14362–14367. Published online 2002 October 21. doi: 10.1073/pnas.222536599.PMCID: PMC137889 Despite ubiquitous autoantigen expression, arthritogenic autoantibody response initiates in the local lymph node Laura Mandik-Nayak, Brian T. Wipke, Fei F. Shih, Emil R. Unanue, and Paul M. Allen Proc Natl Acad Sci U S A. 2002 October 29; 99(22): 14368–14373. Published online 2002 October 21. doi: 10.1073/pnas.182549099.PMCID: PMC137890 Medical Sciences Molecular sequelae of proteasome inhibition in human multiple myeloma cells Nicholas Mitsiades, Constantine S. Mitsiades, Vassiliki Poulaki, Dharminder Chauhan, Galinos Fanourakis, Xuesong Gu, Charles Bailey, Marie Joseph, Towia A. Libermann, Steven P. Treon, Nikhil C. Munshi, Paul G. Richardson, Teru Hideshima, and Kenneth C. Anderson Proc Natl Acad Sci U S A. 2002 October 29; 99(22): 14374–14379. Published online 2002 October 21. doi: 10.1073/pnas.202445099.PMCID: PMC137891 Permanent and panerythroid correction of murine β thalassemia by multiple lentiviral integration in hematopoietic stem cells Suzan Imren, Emmanuel Payen, Karen A. Westerman, Robert Pawliuk, Mary E. Fabry, Connie J. Eaves, Benjamin Cavilla, Louis D. Wadsworth, Yves Beuzard, Eric E. Bouhassira, Robert Russell, Irving M. London, Ronald L. Nagel, Philippe Leboulch, and R. Keith Humphries Proc Natl Acad Sci U S A. 2002 October 29; 99(22): 14380–14385. Published online 2002 October 21. doi: 10.1073/pnas.212507099.PMCID: PMC137892 Cardiomyocytes undergo apoptosis in human immunodeficiency virus cardiomyopathy through mitochondrion- and death receptor-controlled pathways Cheryl Twu, Nancy Q. Liu, Waldemar Popik, Michael Bukrinsky, James Sayre, Jaclyn Roberts, Shammas Rania, Vishnu Bramhandam, Kenneth P. Roos, W. Robb MacLellan, and Milan Fiala Proc Natl Acad Sci U S A. 2002 October 29; 99(22): 14386–14391. Published online 2002 October 11. doi: 10.1073/pnas.212327899.PMCID: PMC137893 Dysregulated TCL1 promotes multiple classes of mature B cell lymphoma Katrina K. Hoyer, Samuel W. French, Devin E. Turner, Mai T. N. Nguyen, Mathilde Renard, Cindy S. Malone, Sonja Knoetig, Chen-Feng Qi, Thomas T. Su, Hilde Cheroutre, Randolph Wall, David J. Rawlings, Herbert C. Morse, III, and Michael A. Teitell Proc Natl Acad Sci U S A. 2002 October 29; 99(22): 14392–14397. Published online 2002 October 14. doi: 10.1073/pnas.212410199.PMCID: PMC137894 Inhibitors of Ras/Raf-1 interaction identified by two-hybrid screening revert Ras-dependent transformation phenotypes in human cancer cells Juran Kato-Stankiewicz, Irina Hakimi, Gang Zhi, Jie Zhang, Ilya Serebriiskii, Lea Guo, Hironori Edamatsu, Hiroshi Koide, Sanjay Menon, Robert Eckl, Sukumar Sakamuri, Yingchun Lu, Quin-Zene Chen, Seema Agarwal, William R. Baumbach, Erica A. Golemis, Fuyuhiko Tamanoi, and Vladimir Khazak Proc Natl Acad Sci U S A. 2002 October 29; 99(22): 14398–14403. Published online 2002 October 21. doi: 10.1073/pnas.222222699.PMCID: PMC137895 Expression of colony-stimulating factor 1 receptor during prostate development and prostate cancer progression Hisamitsu Ide, David B. Seligson, Sanaz Memarzadeh, Li Xin, Steve Horvath, Purnima Dubey, Maryann B. Flick, Barry M. Kacinski, Aarno Palotie, and Owen N. Witte Proc Natl Acad Sci U S A. 2002 October 29; 99(22): 14404–14409. Published online 2002 October 15. doi: 10.1073/pnas.222537099.PMCID: PMC137896 Structure of HIV-2 reverse transcriptase at 2.35-Å resolution and the mechanism of resistance to non-nucleoside inhibitors J. Ren, L. E. Bird, P. P. Chamberlain, G. B. Stewart-Jones, D. I. Stuart, and D. K. Stammers Proc Natl Acad Sci U S A. 2002 October 29; 99(22): 14410–14415. Published online 2002 October 17. doi: 10.1073/pnas.222366699.PMCID: PMC137897 Mutations that permit efficient replication of hepatitis C virus RNA in Huh-7 cells prevent productive replication in chimpanzees Jens Bukh, Thomas Pietschmann, Volker Lohmann, Nicole Krieger, Kristina Faulk, Ronald E. Engle, Sugantha Govindarajan, Max Shapiro, Marisa St. Claire, and Ralf Bartenschlager Proc Natl Acad Sci U S A. 2002 October 29; 99(22): 14416–14421. Published online 2002 October 21. doi: 10.1073/pnas.212532699.PMCID: PMC137898 Microbiology The genome sequence of Bifidobacterium longum reflects its adaptation to the human gastrointestinal tract Mark A. Schell, Maria Karmirantzou, Berend Snel, David Vilanova, Bernard Berger, Gabriella Pessi, Marie-Camille Zwahlen, Frank Desiere, Peer Bork, Michele Delley, R. David Pridmore, and Fabrizio Arigoni Proc Natl Acad Sci U S A. 2002 October 29; 99(22): 14422–14427. Published online 2002 October 15. doi: 10.1073/pnas.212527599.PMCID: PMC137899 Biological activity of the Helicobacter pylori virulence factor CagA is determined by variation in the tyrosine phosphorylation sites Hideaki Higashi, Ryouhei Tsutsumi, Akiko Fujita, Shiho Yamazaki, Masahiro Asaka, Takeshi Azuma, and Masanori Hatakeyama Proc Natl Acad Sci U S A. 2002 October 29; 99(22): 14428–14433. Published online 2002 October 21. doi: 10.1073/pnas.222375399.PMCID: PMC137900 Genome sequence of Streptococcus mutans UA159, a cariogenic dental pathogen Dragana Ajdić, William M. McShan, Robert E. McLaughlin, Gorana Savić, Jin Chang, Matthew B. Carson, Charles Primeaux, Runying Tian, Steve Kenton, Honggui Jia, Shaoping Lin, Yudong Qian, Shuling Li, Hua Zhu, Fares Najar, Hongshing Lai, Jim White, Bruce A. Roe, and Joseph J. Ferretti Proc Natl Acad Sci U S A. 2002 October 29; 99(22): 14434–14439. Published online 2002 October 23. doi: 10.1073/pnas.172501299.PMCID: PMC137901 A synthetic HIV-1 Rev inhibitor interfering with the CRM1-mediated nuclear export Dirk Daelemans, Elena Afonina, Jakob Nilsson, Gudrun Werner, Jørgen Kjems, Erik De Clercq, George N. Pavlakis, and Anne-Mieke Vandamme Proc Natl Acad Sci U S A. 2002 October 29; 99(22): 14440–14445. Published online 2002 October 9. doi: 10.1073/pnas.212285299.PMCID: PMC137902 Bradyoxetin, a unique chemical signal involved in symbiotic gene regulation John Loh, Russell W. Carlson, William S. York, and Gary Stacey Proc Natl Acad Sci U S A. 2002 October 29; 99(22): 14446–14451. Published online 2002 October 22. doi: 10.1073/pnas.222336799.PMCID: PMC137903 Neuroscience Alleles at the Nicastrin locus modify presenilin 1- deficiency phenotype Richard Rozmahel, Howard T. J. Mount, Fusheng Chen, Van Nguyen, Jean Huang, Serap Erdebil, Jennifer Liauw, Gang Yu, Hiroshe Hasegawa, YongJun Gu, You-Qiang Song, Stephen D. Schmidt, Ralph A. Nixon, Paul M. Mathews, Catherine Bergeron, Paul Fraser, David Westaway, and Peter St George-Hyslop Proc Natl Acad Sci U S A. 2002 October 29; 99(22): 14452–14457. Published online 2002 October 18. doi: 10.1073/pnas.222413999.PMCID: PMC137904 Multiple spatiotemporal modes of actin reorganization by NMDA receptors and voltage-gated Ca2+ channels Tomoyuki Furuyashiki, Yoshiki Arakawa, Sayaka Takemoto-Kimura, Haruhiko Bito, and Shuh Narumiya Proc Natl Acad Sci U S A. 2002 October 29; 99(22): 14458–14463. Published online 2002 October 21. doi: 10.1073/pnas.212148999.PMCID: PMC137905 A family of RIM-binding proteins regulated by alternative splicing: Implications for the genesis of synaptic active zones Yun Wang, Xinran Liu, Thomas Biederer, and Thomas C. Südhof Proc Natl Acad Sci U S A. 2002 October 29; 99(22): 14464–14469. Published online 2002 October 21. doi: 10.1073/pnas.182532999.PMCID: PMC137906 Internalization and recycling of 5-HT2A receptors activated by serotonin and protein kinase C-mediated mechanisms Samarjit Bhattacharyya, Sapna Puri, Ricardo Miledi, and Mitradas M. Panicker Proc Natl Acad Sci U S A. 2002 October 29; 99(22): 14470–14475. Published online 2002 October 18. doi: 10.1073/pnas.212517999.PMCID: PMC137907 Impaired recycling of synaptic vesicles after acute perturbation of the presynaptic actin cytoskeleton Oleg Shupliakov, Ona Bloom, Jenny S. Gustafsson, Ole Kjaerulff, Peter Löw, Nikolay Tomilin, Vincent A. Pieribone, Paul Greengard, and Lennart Brodin Proc Natl Acad Sci U S A. 2002 October 29; 99(22): 14476–14481. Published online 2002 October 15. doi: 10.1073/pnas.212381799.PMCID: PMC137908 A probabilistic explanation of brightness scaling Surajit Nundy and Dale Purves Proc Natl Acad Sci U S A. 2002 October 29; 99(22): 14482–14487. Published online 2002 October 18. doi: 10.1073/pnas.172520399.PMCID: PMC137909 The identification of vesicular glutamate transporter 3 suggests novel modes of signaling by glutamate Robert T. Fremeau, Jr., Jonathon Burman, Tayyaba Qureshi, Cindy H. Tran, John Proctor, Juliette Johnson, Hui Zhang, David Sulzer, David R. Copenhagen, Jon Storm-Mathisen, Richard J. Reimer, Farrukh A. Chaudhry, and Robert H. Edwards Proc Natl Acad Sci U S A. 2002 October 29; 99(22): 14488–14493. Published online 2002 October 18. doi: 10.1073/pnas.222546799.PMCID: PMC137910 Two different inward rectifier K+ channels are effectors for transmitter-induced slow excitation in brain neurons D. Bajic, M. Koike, A. M. Albsoul-Younes, S. Nakajima, and Y. Nakajima Proc Natl Acad Sci U S A. 2002 October 29; 99(22): 14494–14499. Published online 2002 October 21. doi: 10.1073/pnas.222379999.PMCID: PMC137911 Overexpression of motor protein KIF17 enhances spatial and working memory in transgenic mice Richard Wing-Chuen Wong, Mitsutoshi Setou, Junlin Teng, Yosuke Takei, and Nobutaka Hirokawa Proc Natl Acad Sci U S A. 2002 October 29; 99(22): 14500–14505. Published online 2002 October 21. doi: 10.1073/pnas.222371099.PMCID: PMC137912 Neural stem cell heterogeneity demonstrated by molecular phenotyping of clonal neurospheres Oleg N. Suslov, Valery G. Kukekov, Tatyana N. Ignatova, and Dennis A. Steindler Proc Natl Acad Sci U S A. 2002 October 29; 99(22): 14506–14511. Published online 2002 October 15. doi: 10.1073/pnas.212525299.PMCID: PMC137913 Bidirectional plasticity of excitatory postsynaptic potential (EPSP)-spike coupling in CA1 hippocampal pyramidal neurons Gaël Daoudal, Yasuhiro Hanada, and Dominique Debanne Proc Natl Acad Sci U S A. 2002 October 29; 99(22): 14512–14517. Published online 2002 October 21. doi: 10.1073/pnas.222546399.PMCID: PMC137914 The role of ipsilateral premotor cortex in hand movement after stroke Heidi Johansen-Berg, Matthew F. S. Rushworth, Marko D. Bogdanovic, Udo Kischka, Sunil Wimalaratna, and Paul M. Matthews Proc Natl Acad Sci U S A. 2002 October 29; 99(22): 14518–14523. Published online 2002 October 10. doi: 10.1073/pnas.222536799.PMCID: PMC137915 From the Cover: Resistance of α-synuclein null mice to the parkinsonian neurotoxin MPTP William Dauer, Nikolai Kholodilov, Miquel Vila, Anne-Cecile Trillat, Rose Goodchild, Kristin E. Larsen, Roland Staal, Kim Tieu, Yvonne Schmitz, Chao Annie Yuan, Marcelo Rocha, Vernice Jackson-Lewis, Steven Hersch, David Sulzer, Serge Przedborski, Robert Burke, and Rene Hen Proc Natl Acad Sci U S A. 2002 October 29; 99(22): 14524–14529. Published online 2002 October 10. doi: 10.1073/pnas.172514599.PMCID: PMC137916 Control of lactotrop proliferation by dopamine: Essential role of signaling through D2 receptors and ERKs Ciro Iaccarino, Tarek A. Samad, Carole Mathis, Henri Kercret, Roberto Picetti, and Emiliana Borrelli Proc Natl Acad Sci U S A. 2002 October 29; 99(22): 14530–14535. Published online 2002 October 21. doi: 10.1073/pnas.222319599.PMCID: PMC137917 A GDP/GTP exchange protein for the Rab3 small G protein family up-regulates a postdocking step of synaptic exocytosis in central synapses Kazuhiko Yamaguchi, Miki Tanaka, Akira Mizoguchi, Yoshihiro Hirata, Hiroyoshi Ishizaki, Kumi Kaneko, Jun Miyoshi, and Yoshimi Takai Proc Natl Acad Sci U S A. 2002 October 29; 99(22): 14536–14541. Published online 2002 October 18. doi: 10.1073/pnas.212511399.PMCID: PMC137918 Cofactors of serine racemase that physiologically stimulate the synthesis of the N-methyl-d-aspartate (NMDA) receptor coagonist d-serine Joari de Miranda, Rogerio Panizzutti, Veronika N. Foltyn, and Herman Wolosker Proc Natl Acad Sci U S A. 2002 October 29; 99(22): 14542–14547. Published online 2002 October 22. doi: 10.1073/pnas.222421299.PMCID: PMC137919 Pharmacology From the Cover: Selenomethionine regulation of p53 by a ref1-dependent redox mechanism Young R. Seo, Mark R. Kelley, and Martin L. Smith Proc Natl Acad Sci U S A. 2002 October 29; 99(22): 14548–14553. Published online 2002 September 30. doi: 10.1073/pnas.212319799.PMCID: PMC137920 A Drosophila dopamine 2-like receptor: Molecular characterization and identification of multiple alternatively spliced variants Mark G. Hearn, Yong Ren, Edward W. McBride, Isabelle Reveillaud, Martin Beinborn, and Alan S. Kopin Proc Natl Acad Sci U S A. 2002 October 29; 99(22): 14554–14559. Published online 2002 October 21. doi: 10.1073/pnas.202498299.PMCID: PMC137921 Physiology Coupling of c-Src to large conductance voltage- and Ca2+-activated K+ channels as a new mechanism of agonist-induced vasoconstriction Abderrahmane Alioua, Aman Mahajan, Kazuhide Nishimaru, Masoud M. Zarei, Enrico Stefani, and Ligia Toro Proc Natl Acad Sci U S A. 2002 October 29; 99(22): 14560–14565. Published online 2002 October 21. doi: 10.1073/pnas.222348099.PMCID: PMC137922 Nicotinic acid-adenine dinucleotide phosphate-sensitive calcium stores initiate insulin signaling in human beta cells James D. Johnson and Stanley Misler Proc Natl Acad Sci U S A. 2002 October 29; 99(22): 14566–14571. Published online 2002 October 15. doi: 10.1073/pnas.222099799.PMCID: PMC137923 Na pump isoforms in human erythroid progenitor cells and mature erythrocytes Joseph F. Hoffman, Amittha Wickrema, Olga Potapova, Mark Milanick, and Douglas R. Yingst Proc Natl Acad Sci U S A. 2002 October 29; 99(22): 14572–14577. Published online 2002 October 18. doi: 10.1073/pnas.222539999.PMCID: PMC137924 Plant Biology Bottlenecks for metabolic engineering of isoflavone glycoconjugates in Arabidopsis Chang-Jun Liu, Jack W. Blount, Christopher L. Steele, and Richard A. Dixon Proc Natl Acad Sci U S A. 2002 October 29; 99(22): 14578–14583. Published online 2002 October 16. doi: 10.1073/pnas.212522099.PMCID: PMC137925 Interphase chromosomes in Arabidopsis are organized as well defined chromocenters from which euchromatin loops emanate Paul Fransz, J. Hans de Jong, Martin Lysak, Monica Ruffini Castiglione, and Ingo Schubert Proc Natl Acad Sci U S A. 2002 October 29; 99(22): 14584–14589. Published online 2002 October 16. doi: 10.1073/pnas.212325299.PMCID: PMC137926 Population Biology Wind-dispersed pollen mediates postglacial gene flow among refugia Sascha Liepelt, Ronald Bialozyt, and Birgit Ziegenhagen Proc Natl Acad Sci U S A. 2002 October 29; 99(22): 14590–14594. Published online 2002 October 21. doi: 10.1073/pnas.212285399.PMCID: PMC137927 Psychology (Biological Sciences) Fractionating the neural substrate of cognitive control processes Jean-Claude Dreher and Karen Faith Berman Proc Natl Acad Sci U S A. 2002 October 29; 99(22): 14595–14600. Published online 2002 October 21. doi: 10.1073/pnas.222193299.PMCID: PMC137928 Auditory system: Peripheral nonlinearity and central additivity, as revealed in the human stapedius-muscle reflex Jozef J. Zwislocki Proc Natl Acad Sci U S A. 2002 October 29; 99(22): 14601–14606. Published online 2002 October 18. doi: 10.1073/pnas.222543199.PMCID: PMC137929 Social Sciences Psychology Estimating physical reflectance spectra from human color-matching experiments A. Kimball Romney and Tarow Indow Proc Natl Acad Sci U S A. 2002 October 29; 99(22): 14607–14610. Published online 2002 October 18. doi: 10.1073/pnas.222558899.PMCID: PMC137930 Corrections Proc Natl Acad Sci U S A. 2002 October 29; 99(22): 14611. Published online 2002 October 24. doi: 10.1073/pnas.222517899.PMCID: PMC137816 Corrects: Brian C. Schutte, et al. Discovery of five conserved β-defensin gene clusters using a computational search strategy. Proc Natl Acad Sci U S A. 2002 February 19; 99(4): 2129–2133. Proc Natl Acad Sci U S A. 2002 October 29; 99(22): 14611. Published online 2002 October 10. doi: 10.1073/pnas.222515799.PMCID: PMC137817 Corrects: Julius C. R. Hafalla, et al. Short-term antigen presentation and single clonal burst limit the magnitude of the CD8+ T cell responses to malaria liver stages. Proc Natl Acad Sci U S A. 2002 September 3; 99(18): 11819–11824. |