pmc logo imageJournal ListSearchpmc logo image
Logo of pnasPNAS Home page.PNAS Editorial BoardPNAS AboutPNAS SubscriptionsPNAS Info for Authors
This journal provides immediate access to some articles.
Other Issues:  previous | next | latest | archive
Volume 99(22);  October 29, 2002
Commentaries
A copper connection to the uptake of platinum anticancer drugs
John L. Nitiss
Proc Natl Acad Sci U S A. 2002 October 29; 99(22): 13963–13965. Published online 2002 October 21. doi: 10.1073/pnas.232574299.
PMCID: PMC137818
The inner inner core of Earth
Don L. Anderson
Proc Natl Acad Sci U S A. 2002 October 29; 99(22): 13966–13968. Published online 2002 October 21. doi: 10.1073/pnas.232565899.
PMCID: PMC137819
New careers for antioxidants
Douglas E. Brash and P. A. Havre
Proc Natl Acad Sci U S A. 2002 October 29; 99(22): 13969–13971. Published online 2002 October 21. doi: 10.1073/pnas.232574399.
PMCID: PMC137820
Etiology of Parkinson's disease: Genetics and environment revisited
Kathy Steece-Collier, Eleonora Maries, and Jeffrey H. Kordower
Proc Natl Acad Sci U S A. 2002 October 29; 99(22): 13972–13974. Published online 2002 October 21. doi: 10.1073/pnas.242594999.
PMCID: PMC137821
Physical Sciences
Applied Mathematics
Near strongly resonant periodic orbits in a Hamiltonian system
Vassili Gelfreich
Proc Natl Acad Sci U S A. 2002 October 29; 99(22): 13975–13979. Published online 2002 October 21. doi: 10.1073/pnas.212116699.
PMCID: PMC137822
Distributional regimes for the number of k-word matches between two random sequences
Ross A. Lippert, Haiyan Huang, and Michael S. Waterman
Proc Natl Acad Sci U S A. 2002 October 29; 99(22): 13980–13989. Published online 2002 October 8. doi: 10.1073/pnas.202468099.
PMCID: PMC137823
Applied Physical Sciences
Neurotoxic effects of thioflavin S-positive amyloid deposits in transgenic mice and Alzheimer's disease
B. Urbanc, L. Cruz, R. Le, J. Sanders, K. Hsiao Ashe, K. Duff, H. E. Stanley, M. C. Irizarry, and B. T. Hyman
Proc Natl Acad Sci U S A. 2002 October 29; 99(22): 13990–13995. Published online 2002 October 9. doi: 10.1073/pnas.222433299.
PMCID: PMC137824
Chemistry
Bioactive alkaloids of frog skin: Combinatorial bioprospecting reveals that pumiliotoxins have an arthropod source
John W. Daly, Tetsuo Kaneko, Jason Wilham, H. Martin Garraffo, Thomas F. Spande, Alex Espinosa, and Maureen A. Donnelly
Proc Natl Acad Sci U S A. 2002 October 29; 99(22): 13996–14001. Published online 2002 October 14. doi: 10.1073/pnas.222551599.
PMCID: PMC137825
A polyketide synthase-peptide synthetase gene cluster from an uncultured bacterial symbiont of Paederus beetles
Jörn Piel
Proc Natl Acad Sci U S A. 2002 October 29; 99(22): 14002–14007. Published online 2002 October 14. doi: 10.1073/pnas.222481399.
PMCID: PMC137826
Biodirected epitaxial nanodeposition of polymers on oriented macromolecular templates
Tetsuo Kondo, Masanobu Nojiri, Yukako Hishikawa, Eiji Togawa, Dwight Romanovicz, and R. Malcolm Brown, Jr.
Proc Natl Acad Sci U S A. 2002 October 29; 99(22): 14008–14013. Published online 2002 October 10. doi: 10.1073/pnas.212238399.
PMCID: PMC137827
Computer Sciences
Growing and navigating the small world Web by local content
Filippo Menczer
Proc Natl Acad Sci U S A. 2002 October 29; 99(22): 14014–14019. Published online 2002 October 14. doi: 10.1073/pnas.212348399.
PMCID: PMC137828
Geophysics
From the Cover:
The Cretaceous superchron geodynamo: Observations near the tangent cylinder
John A. Tarduno, Rory D. Cottrell, and Alexei V. Smirnov
Proc Natl Acad Sci U S A. 2002 October 29; 99(22): 14020–14025. Published online 2002 October 18. doi: 10.1073/pnas.222373499.
PMCID: PMC137829
From the Cover:
The innermost inner core of the earth: Evidence for a change in anisotropic behavior at the radius of about 300 km
Miaki Ishii and Adam M. Dziewoński
Proc Natl Acad Sci U S A. 2002 October 29; 99(22): 14026–14030. Published online 2002 October 8. doi: 10.1073/pnas.172508499.
PMCID: PMC137830
Physics
Estimating physical reflectance spectra from human color-matching experiments
A. Kimball Romney and Tarow Indow
Proc Natl Acad Sci U S A. 2002 October 29; 99(22): 14607–14610. Published online 2002 October 18. doi: 10.1073/pnas.222558899.
PMCID: PMC137930
Statistics
Quantitative noise analysis for gene expression microarray experiments
Y. Tu, G. Stolovitzky, and U. Klein
Proc Natl Acad Sci U S A. 2002 October 29; 99(22): 14031–14036. Published online 2002 October 18. doi: 10.1073/pnas.222164199.
PMCID: PMC137831
Biological Sciences
Biochemistry
An approach to membrane protein structure without crystals
Paul L. Sorgen, Yonglin Hu, Lan Guan, H. Ronald Kaback, and Mark E. Girvin
Proc Natl Acad Sci U S A. 2002 October 29; 99(22): 14037–14040. Published online 2002 October 21. doi: 10.1073/pnas.182552199.
PMCID: PMC137832
Crystal structure of the DNA-binding domain from Ndt80, a transcriptional activator required for meiosis in yeast
Sherwin P. Montano, Marie L. Coté, Ian Fingerman, Michael Pierce, Andrew K. Vershon, and Millie M. Georgiadis
Proc Natl Acad Sci U S A. 2002 October 29; 99(22): 14041–14046. Published online 2002 October 16. doi: 10.1073/pnas.222312199.
PMCID: PMC137833
A nucleolar TAR decoy inhibitor of HIV-1 replication
Alessandro Michienzi, Shirley Li, John A. Zaia, and John J. Rossi
Proc Natl Acad Sci U S A. 2002 October 29; 99(22): 14047–14052. Published online 2002 October 10. doi: 10.1073/pnas.212229599.
PMCID: PMC137834
Structure of a regulatory complex involving the Abl SH3 domain, the Crk SH2 domain, and a Crk-derived phosphopeptide
Logan W. Donaldson, Gerald Gish, Tony Pawson, Lewis E. Kay, and Julie D. Forman-Kay
Proc Natl Acad Sci U S A. 2002 October 29; 99(22): 14053–14058. Published online 2002 October 16. doi: 10.1073/pnas.212518799.
PMCID: PMC137835
Three-dimensional model of the human platelet integrin αIIbβ3 based on electron cryomicroscopy and x-ray crystallography
Brian D. Adair and Mark Yeager
Proc Natl Acad Sci U S A. 2002 October 29; 99(22): 14059–14064. Published online 2002 October 18. doi: 10.1073/pnas.212498199.
PMCID: PMC137836
Structure of the GCN5 histone acetyltransferase bound to a bisubstrate inhibitor
Arienne N. Poux, Marek Cebrat, Cheol M. Kim, Philip A. Cole, and Ronen Marmorstein
Proc Natl Acad Sci U S A. 2002 October 29; 99(22): 14065–14070. Published online 2002 October 21. doi: 10.1073/pnas.222373899.
PMCID: PMC137837
Small molecule modulation of Smoothened activity
James K. Chen, Jussi Taipale, Keith E. Young, Tapan Maiti, and Philip A. Beachy
Proc Natl Acad Sci U S A. 2002 October 29; 99(22): 14071–14076. Published online 2002 October 21. doi: 10.1073/pnas.182542899.
PMCID: PMC137838
Promiscuity in ligand-binding: The three-dimensional structure of a Piromyces carbohydrate-binding module, CBM29-2, in complex with cello- and mannohexaose
Simon J. Charnock, David N. Bolam, Didier Nurizzo, Lóránd Szabó, Vincent A. McKie, Harry J. Gilbert, and Gideon J. Davies
Proc Natl Acad Sci U S A. 2002 October 29; 99(22): 14077–14082. Published online 2002 October 21. doi: 10.1073/pnas.212516199.
PMCID: PMC137839
Regeneration of misprimed nonribosomal peptide synthetases by type II thioesterases
Dirk Schwarzer, Henning D. Mootz, Uwe Linne, and Mohamed A. Marahiel
Proc Natl Acad Sci U S A. 2002 October 29; 99(22): 14083–14088. Published online 2002 October 16. doi: 10.1073/pnas.212382199.
PMCID: PMC137840
Does RNA polymerase help drive chromosome segregation in bacteria?
Jonathan Dworkin and Richard Losick
Proc Natl Acad Sci U S A. 2002 October 29; 99(22): 14089–14094. Published online 2002 October 16. doi: 10.1073/pnas.182539899.
PMCID: PMC137841
[var phi] value analysis of heterogeneity in pathways of allosteric transitions: Evidence for parallel pathways of ATP-induced conformational changes in a GroEL ring
Amnon Horovitz, Amnon Amir, Oded Danziger, and Galit Kafri
Proc Natl Acad Sci U S A. 2002 October 29; 99(22): 14095–14097. Published online 2002 October 18. doi: 10.1073/pnas.222303299.
PMCID: PMC137842
Bacterial redox protein azurin, tumor suppressor protein p53, and regression of cancer
Tohru Yamada, Masatoshi Goto, Vasu Punj, Olga Zaborina, Mei Ling Chen, Kazuhide Kimbara, Dibyen Majumdar, Elizabeth Cunningham, Tapas K. Das Gupta, and Ananda M. Chakrabarty
Proc Natl Acad Sci U S A. 2002 October 29; 99(22): 14098–14103. Published online 2002 October 22. doi: 10.1073/pnas.222539699.
PMCID: PMC137843
Tubulin is the endogenous inhibitor of the glyceraldehyde 3-phosphate dehydrogenase isoform that catalyzes membrane fusion: Implications for the coordinated regulation of glycolysis and membrane fusion
Paul E. Glaser, Xianlin Han, and Richard W. Gross
Proc Natl Acad Sci U S A. 2002 October 29; 99(22): 14104–14109. Published online 2002 October 15. doi: 10.1073/pnas.222542999.
PMCID: PMC137844
Biophysics
Pairs of dipeptides synergistically activate the binding of substrate by ubiquitin ligase through dissociation of its autoinhibitory domain
Fangyong Du, Federico Navarro-Garcia, Zanxian Xia, Takafumi Tasaki, and Alexander Varshavsky
Proc Natl Acad Sci U S A. 2002 October 29; 99(22): 14110–14115. Published online 2002 October 21. doi: 10.1073/pnas.172527399.
PMCID: PMC137845
A simple physical model for binding energy hot spots in protein–protein complexes
Tanja Kortemme and David Baker
Proc Natl Acad Sci U S A. 2002 October 29; 99(22): 14116–14121. Published online 2002 October 15. doi: 10.1073/pnas.202485799.
PMCID: PMC137846
On the simulation of protein folding by short time scale molecular dynamics and distributed computing
Alan R. Fersht
Proc Natl Acad Sci U S A. 2002 October 29; 99(22): 14122–14125. Published online 2002 October 18. doi: 10.1073/pnas.182542699.
PMCID: PMC137847
Stabilities and conformations of Alzheimer's β-amyloid peptide oligomers (Aβ1622, Aβ16–35, and Aβ1035): Sequence effects
Buyong Ma and Ruth Nussinov
Proc Natl Acad Sci U S A. 2002 October 29; 99(22): 14126–14131. Published online 2002 October 21. doi: 10.1073/pnas.212206899.
PMCID: PMC137848
Expanding protein universe and its origin from the biological Big Bang
Nikolay V. Dokholyan, Boris Shakhnovich, and Eugene I. Shakhnovich
Proc Natl Acad Sci U S A. 2002 October 29; 99(22): 14132–14136. Published online 2002 October 16. doi: 10.1073/pnas.202497999.
PMCID: PMC137849
Common features in structures and sequences of sandwich-like proteins
Alexander E. Kister, Alexei V. Finkelstein, and Israel M. Gelfand
Proc Natl Acad Sci U S A. 2002 October 29; 99(22): 14137–14141. Published online 2002 October 16. doi: 10.1073/pnas.212511499.
PMCID: PMC137850
Electronic detection of DNA by its intrinsic molecular charge
Jürgen Fritz, Emily B. Cooper, Suzanne Gaudet, Peter K. Sorger, and Scott R. Manalis
Proc Natl Acad Sci U S A. 2002 October 29; 99(22): 14142–14146. Published online 2002 October 17. doi: 10.1073/pnas.232276699.
PMCID: PMC137851
Molecular topography imaging by intermembrane fluorescence resonance energy transfer
Amy P. Wong and Jay T. Groves
Proc Natl Acad Sci U S A. 2002 October 29; 99(22): 14147–14152. Published online 2002 October 21. doi: 10.1073/pnas.212392599.
PMCID: PMC137852
Identification of macromolecular complexes in cryoelectron tomograms of phantom cells
Achilleas S. Frangakis, Jochen Böhm, Friedrich Förster, Stephan Nickell, Daniela Nicastro, Dieter Typke, Reiner Hegerl, and Wolfgang Baumeister
Proc Natl Acad Sci U S A. 2002 October 29; 99(22): 14153–14158. Published online 2002 October 21. doi: 10.1073/pnas.172520299.
PMCID: PMC137853
Role of the lever arm in the processive stepping of myosin V
Thomas J. Purcell, Carl Morris, James A. Spudich, and H. Lee Sweeney
Proc Natl Acad Sci U S A. 2002 October 29; 99(22): 14159–14164. Published online 2002 October 17. doi: 10.1073/pnas.182539599.
PMCID: PMC137854
Effect of polyethylene glycol on the liquid–liquid phase transition in aqueous protein solutions
Onofrio Annunziata, Neer Asherie, Aleksey Lomakin, Jayanti Pande, Olutayo Ogun, and George B. Benedek
Proc Natl Acad Sci U S A. 2002 October 29; 99(22): 14165–14170. Published online 2002 October 21. doi: 10.1073/pnas.212507199.
PMCID: PMC137855
Measurement of microsecond dynamic motion in the intestinal fatty acid binding protein by using fluorescence correlation spectroscopy
Krishnananda Chattopadhyay, Saveez Saffarian, Elliot L. Elson, and Carl Frieden
Proc Natl Acad Sci U S A. 2002 October 29; 99(22): 14171–14176. Published online 2002 October 15. doi: 10.1073/pnas.172524899.
PMCID: PMC137856
Cell Biology
Glucose is toxic to glycosome-deficient trypanosomes
Tetsuya Furuya, Peter Kessler, Armando Jardim, Achim Schnaufer, Christopher Crudder, and Marilyn Parsons
Proc Natl Acad Sci U S A. 2002 October 29; 99(22): 14177–14182. Published online 2002 October 17. doi: 10.1073/pnas.222454899.
PMCID: PMC137857
Cell surface polarization during yeast mating
Michel Bagnat and Kai Simons
Proc Natl Acad Sci U S A. 2002 October 29; 99(22): 14183–14188. Published online 2002 October 8. doi: 10.1073/pnas.172517799.
PMCID: PMC137858
JLP: A scaffolding protein that tethers JNK/p38MAPK signaling modules and transcription factors
Clement M. Lee, Djamila Onésime, C. Damodara Reddy, N. Dhanasekaran, and E. Premkumar Reddy
Proc Natl Acad Sci U S A. 2002 October 29; 99(22): 14189–14194. Published online 2002 October 21. doi: 10.1073/pnas.232310199.
PMCID: PMC137859
Karyopherin β2B participates in mRNA export from the nucleus
Monee K. Shamsher, Jonathan Ploski, and Aurelian Radu
Proc Natl Acad Sci U S A. 2002 October 29; 99(22): 14195–14199. Published online 2002 October 16. doi: 10.1073/pnas.212518199.
PMCID: PMC137860
RB activation defect in tumor cell lines
Cristina Broceño, Scott Wilkie, and Sibylle Mittnacht
Proc Natl Acad Sci U S A. 2002 October 29; 99(22): 14200–14205. Published online 2002 October 11. doi: 10.1073/pnas.212519499.
PMCID: PMC137861
Inositol pyrophosphates regulate endocytic trafficking
Adolfo Saiardi, Catherine Sciambi, J. Michael McCaffery, Beverly Wendland, and Solomon H. Snyder
Proc Natl Acad Sci U S A. 2002 October 29; 99(22): 14206–14211. Published online 2002 October 21. doi: 10.1073/pnas.212527899.
PMCID: PMC137862
Identification of a negative response element in the human inducible nitric-oxide synthase (hiNOS) promoter: The role of NF-κB-repressing factor (NRF) in basal repression of the hiNOS gene
Xuesheng Feng, Zhong Guo, Mahtab Nourbakhsh, Hansjorg Hauser, Ray Ganster, Lifang Shao, and David A. Geller
Proc Natl Acad Sci U S A. 2002 October 29; 99(22): 14212–14217. Published online 2002 October 15. doi: 10.1073/pnas.212306199.
PMCID: PMC137863
Developmental Biology
The SQV-1 UDP-glucuronic acid decarboxylase and the SQV-7 nucleotide-sugar transporter may act in the Golgi apparatus to affect Caenorhabditis elegans vulval morphogenesis and embryonic development
Ho-Yon Hwang and H. Robert Horvitz
Proc Natl Acad Sci U S A. 2002 October 29; 99(22): 14218–14223. Published online 2002 October 21. doi: 10.1073/pnas.172522199.
PMCID: PMC137864
The Caenorhabditis elegans vulval morphogenesis gene sqv-4 encodes a UDP-glucose dehydrogenase that is temporally and spatially regulated
Ho-Yon Hwang and H. Robert Horvitz
Proc Natl Acad Sci U S A. 2002 October 29; 99(22): 14224–14229. Published online 2002 October 21. doi: 10.1073/pnas.172522499.
PMCID: PMC137865
Efficient production by sperm-mediated gene transfer of human decay accelerating factor (hDAF) transgenic pigs for xenotransplantation
Marialuisa Lavitrano, Maria Laura Bacci, Monica Forni, Davide Lazzereschi, Carla Di Stefano, Daniela Fioretti, Paola Giancotti, Gabriella Marfé, Loredana Pucci, Luigina Renzi, Hongjun Wang, Antonella Stoppacciaro, Giorgio Stassi, Massimo Sargiacomo, Paola Sinibaldi, Valeria Turchi, Roberto Giovannoni, Giacinto Della Casa, Eraldo Seren, and Giancarlo Rossi
Proc Natl Acad Sci U S A. 2002 October 29; 99(22): 14230–14235. Published online 2002 October 22. doi: 10.1073/pnas.222550299.
PMCID: PMC137866
Tissue-specific RNA interference in postimplantation mouse embryos with endoribonuclease-prepared short interfering RNA
Federico Calegari, Wulf Haubensak, Dun Yang, Wieland B. Huttner, and Frank Buchholz
Proc Natl Acad Sci U S A. 2002 October 29; 99(22): 14236–14240. Published online 2002 October 21. doi: 10.1073/pnas.192559699.
PMCID: PMC137867
The signaling domain of the erythropoietin receptor rescues prolactin receptor-mutant mammary epithelium
Cathrin Brisken, Merav Socolovsky, Harvey F. Lodish, and Robert Weinberg
Proc Natl Acad Sci U S A. 2002 October 29; 99(22): 14241–14245. Published online 2002 October 15. doi: 10.1073/pnas.222549599.
PMCID: PMC137868
Ecology
Bioactive alkaloids of frog skin: Combinatorial bioprospecting reveals that pumiliotoxins have an arthropod source
John W. Daly, Tetsuo Kaneko, Jason Wilham, H. Martin Garraffo, Thomas F. Spande, Alex Espinosa, and Maureen A. Donnelly
Proc Natl Acad Sci U S A. 2002 October 29; 99(22): 13996–14001. Published online 2002 October 14. doi: 10.1073/pnas.222551599.
PMCID: PMC137825
A polyketide synthase-peptide synthetase gene cluster from an uncultured bacterial symbiont of Paederus beetles
Jörn Piel
Proc Natl Acad Sci U S A. 2002 October 29; 99(22): 14002–14007. Published online 2002 October 14. doi: 10.1073/pnas.222481399.
PMCID: PMC137826
Interactions of climate change with biological invasions and land use in the Hawaiian Islands: Modeling the fate of endemic birds using a geographic information system
Tracy L. Benning, Dennis LaPointe, Carter T. Atkinson, and Peter M. Vitousek
Proc Natl Acad Sci U S A. 2002 October 29; 99(22): 14246–14249. Published online 2002 October 8. doi: 10.1073/pnas.162372399.
PMCID: PMC137869
Genomic analysis of uncultured marine viral communities
Mya Breitbart, Peter Salamon, Bjarne Andresen, Joseph M. Mahaffy, Anca M. Segall, David Mead, Farooq Azam, and Forest Rohwer
Proc Natl Acad Sci U S A. 2002 October 29; 99(22): 14250–14255. Published online 2002 October 16. doi: 10.1073/pnas.202488399.
PMCID: PMC137870
Carbon emissions from tropical deforestation and regrowth based on satellite observations for the 1980s and 1990s
Ruth S. DeFries, Richard A. Houghton, Matthew C. Hansen, Christopher B. Field, David Skole, and John Townshend
Proc Natl Acad Sci U S A. 2002 October 29; 99(22): 14256–14261. Published online 2002 October 16. doi: 10.1073/pnas.182560099.
PMCID: PMC137871
Evolution
Expanding protein universe and its origin from the biological Big Bang
Nikolay V. Dokholyan, Boris Shakhnovich, and Eugene I. Shakhnovich
Proc Natl Acad Sci U S A. 2002 October 29; 99(22): 14132–14136. Published online 2002 October 16. doi: 10.1073/pnas.202497999.
PMCID: PMC137849
Modularity, individuality, and evo-devo in butterfly wings
Patrícia Beldade, Kees Koops, and Paul M. Brakefield
Proc Natl Acad Sci U S A. 2002 October 29; 99(22): 14262–14267. Published online 2002 October 21. doi: 10.1073/pnas.222236199.
PMCID: PMC137872
Solving the freeloaders paradox: Genetic associations and frequency-dependent selection in the evolution of cooperation among nonrelatives
Leticia Avilés
Proc Natl Acad Sci U S A. 2002 October 29; 99(22): 14268–14273. Published online 2002 October 14. doi: 10.1073/pnas.212408299.
PMCID: PMC137873
Experimental evolution of learning ability in fruit flies
Frederic Mery and Tadeusz J. Kawecki
Proc Natl Acad Sci U S A. 2002 October 29; 99(22): 14274–14279. Published online 2002 October 21. doi: 10.1073/pnas.222371199.
PMCID: PMC137874
Genome fragment of Wolbachia endosymbiont transferred to X chromosome of host insect
Natsuko Kondo, Naruo Nikoh, Nobuyuki Ijichi, Masakazu Shimada, and Takema Fukatsu
Proc Natl Acad Sci U S A. 2002 October 29; 99(22): 14280–14285. Published online 2002 October 17. doi: 10.1073/pnas.222228199.
PMCID: PMC137875
A test of evolutionary theories of aging
Kimberly A. Hughes, Julie A. Alipaz, Jenny M. Drnevich, and Rose M. Reynolds
Proc Natl Acad Sci U S A. 2002 October 29; 99(22): 14286–14291. Published online 2002 October 17. doi: 10.1073/pnas.222326199.
PMCID: PMC137876
Molecular evidence of HIV-1 transmission in a criminal case
Michael L. Metzker, David P. Mindell, Xiao-Mei Liu, Roger G. Ptak, Richard A. Gibbs, and David M. Hillis
Proc Natl Acad Sci U S A. 2002 October 29; 99(22): 14292–14297. Published online 2002 October 18. doi: 10.1073/pnas.222522599.
PMCID: PMC137877
Genetics
From the Cover:
Uptake of the anticancer drug cisplatin mediated by the copper transporter Ctr1 in yeast and mammals
Seiko Ishida, Jaekwon Lee, Dennis J. Thiele, and Ira Herskowitz
Proc Natl Acad Sci U S A. 2002 October 29; 99(22): 14298–14302. Published online 2002 October 7. doi: 10.1073/pnas.162491399.
PMCID: PMC137878
The osteopetrotic mutation toothless (tl) is a loss-of-function frameshift mutation in the rat Csf1 gene: Evidence of a crucial role for CSF-1 in osteoclastogenesis and endochondral ossification
Liesbeth Van Wesenbeeck, Paul R. Odgren, Carole A. MacKay, Marina D'Angelo, Fayez F. Safadi, Steven N. Popoff, Wim Van Hul, and Sandy C. Marks, Jr.
Proc Natl Acad Sci U S A. 2002 October 29; 99(22): 14303–14308. Published online 2002 October 11. doi: 10.1073/pnas.202332999.
PMCID: PMC137879
Hematopoietic-specific activators establish an overlapping pattern of histone acetylation and methylation within a mammalian chromatin domain
Carol M. Kiekhaefer, Jeffrey A. Grass, Kirby D. Johnson, Meghan E. Boyer, and Emery H. Bresnick
Proc Natl Acad Sci U S A. 2002 October 29; 99(22): 14309–14314. Published online 2002 October 11. doi: 10.1073/pnas.212389499.
PMCID: PMC137880
Functional characterization and immunolocalization of the transporter encoded by the life-extending gene Indy
Felix Knauf, Blanka Rogina, Zhirong Jiang, Peter S. Aronson, and Stephen L. Helfand
Proc Natl Acad Sci U S A. 2002 October 29; 99(22): 14315–14319. Published online 2002 October 21. doi: 10.1073/pnas.222531899.
PMCID: PMC137881
Ssdp proteins interact with the LIM-domain-binding protein Ldb1 to regulate development
Lan Chen, Daniel Segal, Neil A. Hukriede, Alexandre V. Podtelejnikov, Dashzeveg Bayarsaihan, James A. Kennison, Vasily V. Ogryzko, Igor B. Dawid, and Heiner Westphal
Proc Natl Acad Sci U S A. 2002 October 29; 99(22): 14320–14325. Published online 2002 October 15. doi: 10.1073/pnas.212532399.
PMCID: PMC137882
A computational/functional genomics approach for the enrichment of the retinal transcriptome and the identification of positional candidate retinopathy genes
Nicholas Katsanis, Kim C. Worley, Guillermo Gonzalez, Stephen J. Ansley, and James R. Lupski
Proc Natl Acad Sci U S A. 2002 October 29; 99(22): 14326–14331. Published online 2002 October 21. doi: 10.1073/pnas.222409099.
PMCID: PMC137883
Heterochromatin protein 2 (HP2), a partner of HP1 in Drosophila heterochromatin
Christopher D. Shaffer, Gena E. Stephens, Brandi A. Thompson, Levi Funches, John A. Bernat, Carolyn A. Craig, and Sarah C. R. Elgin
Proc Natl Acad Sci U S A. 2002 October 29; 99(22): 14332–14337. Published online 2002 October 10. doi: 10.1073/pnas.212458899.
PMCID: PMC137884
Immunology
Protection of the intestinal mucosa by intraepithelial γδ T cells
Yaping Chen, Kevin Chou, Elaine Fuchs, Wendy L. Havran, and Richard Boismenu
Proc Natl Acad Sci U S A. 2002 October 29; 99(22): 14338–14343. Published online 2002 October 10. doi: 10.1073/pnas.212290499.
PMCID: PMC137885
PI31 is a modulator of proteasome formation and antigen processing
Dietmar M. W. Zaiss, Sybille Standera, Peter-M. Kloetzel, and Alice J. A. M. Sijts
Proc Natl Acad Sci U S A. 2002 October 29; 99(22): 14344–14349. Published online 2002 October 8. doi: 10.1073/pnas.212257299.
PMCID: PMC137886
Isolation and characterization of lymphocyte-like cells from a lamprey
Werner E. Mayer, Tatiana Uinuk-ool, Herbert Tichy, Lanier A. Gartland, Jan Klein, and Max D. Cooper
Proc Natl Acad Sci U S A. 2002 October 29; 99(22): 14350–14355. Published online 2002 October 18. doi: 10.1073/pnas.212527499.
PMCID: PMC137887
Lamprey lymphocyte-like cells express homologs of genes involved in immunologically relevant activities of mammalian lymphocytes
Tatiana Uinuk-ool, Werner E. Mayer, Akie Sato, Roman Dongak, Max D. Cooper, and Jan Klein
Proc Natl Acad Sci U S A. 2002 October 29; 99(22): 14356–14361. Published online 2002 October 21. doi: 10.1073/pnas.212527699.
PMCID: PMC137888
Glycosaminoglycans are a potential cause of rheumatoid arthritis
Julia Y. Wang and Michael H. Roehrl
Proc Natl Acad Sci U S A. 2002 October 29; 99(22): 14362–14367. Published online 2002 October 21. doi: 10.1073/pnas.222536599.
PMCID: PMC137889
Despite ubiquitous autoantigen expression, arthritogenic autoantibody response initiates in the local lymph node
Laura Mandik-Nayak, Brian T. Wipke, Fei F. Shih, Emil R. Unanue, and Paul M. Allen
Proc Natl Acad Sci U S A. 2002 October 29; 99(22): 14368–14373. Published online 2002 October 21. doi: 10.1073/pnas.182549099.
PMCID: PMC137890
Medical Sciences
Molecular sequelae of proteasome inhibition in human multiple myeloma cells
Nicholas Mitsiades, Constantine S. Mitsiades, Vassiliki Poulaki, Dharminder Chauhan, Galinos Fanourakis, Xuesong Gu, Charles Bailey, Marie Joseph, Towia A. Libermann, Steven P. Treon, Nikhil C. Munshi, Paul G. Richardson, Teru Hideshima, and Kenneth C. Anderson
Proc Natl Acad Sci U S A. 2002 October 29; 99(22): 14374–14379. Published online 2002 October 21. doi: 10.1073/pnas.202445099.
PMCID: PMC137891
Permanent and panerythroid correction of murine β thalassemia by multiple lentiviral integration in hematopoietic stem cells
Suzan Imren, Emmanuel Payen, Karen A. Westerman, Robert Pawliuk, Mary E. Fabry, Connie J. Eaves, Benjamin Cavilla, Louis D. Wadsworth, Yves Beuzard, Eric E. Bouhassira, Robert Russell, Irving M. London, Ronald L. Nagel, Philippe Leboulch, and R. Keith Humphries
Proc Natl Acad Sci U S A. 2002 October 29; 99(22): 14380–14385. Published online 2002 October 21. doi: 10.1073/pnas.212507099.
PMCID: PMC137892
Cardiomyocytes undergo apoptosis in human immunodeficiency virus cardiomyopathy through mitochondrion- and death receptor-controlled pathways
Cheryl Twu, Nancy Q. Liu, Waldemar Popik, Michael Bukrinsky, James Sayre, Jaclyn Roberts, Shammas Rania, Vishnu Bramhandam, Kenneth P. Roos, W. Robb MacLellan, and Milan Fiala
Proc Natl Acad Sci U S A. 2002 October 29; 99(22): 14386–14391. Published online 2002 October 11. doi: 10.1073/pnas.212327899.
PMCID: PMC137893
Dysregulated TCL1 promotes multiple classes of mature B cell lymphoma
Katrina K. Hoyer, Samuel W. French, Devin E. Turner, Mai T. N. Nguyen, Mathilde Renard, Cindy S. Malone, Sonja Knoetig, Chen-Feng Qi, Thomas T. Su, Hilde Cheroutre, Randolph Wall, David J. Rawlings, Herbert C. Morse, III, and Michael A. Teitell
Proc Natl Acad Sci U S A. 2002 October 29; 99(22): 14392–14397. Published online 2002 October 14. doi: 10.1073/pnas.212410199.
PMCID: PMC137894
Inhibitors of Ras/Raf-1 interaction identified by two-hybrid screening revert Ras-dependent transformation phenotypes in human cancer cells
Juran Kato-Stankiewicz, Irina Hakimi, Gang Zhi, Jie Zhang, Ilya Serebriiskii, Lea Guo, Hironori Edamatsu, Hiroshi Koide, Sanjay Menon, Robert Eckl, Sukumar Sakamuri, Yingchun Lu, Quin-Zene Chen, Seema Agarwal, William R. Baumbach, Erica A. Golemis, Fuyuhiko Tamanoi, and Vladimir Khazak
Proc Natl Acad Sci U S A. 2002 October 29; 99(22): 14398–14403. Published online 2002 October 21. doi: 10.1073/pnas.222222699.
PMCID: PMC137895
Expression of colony-stimulating factor 1 receptor during prostate development and prostate cancer progression
Hisamitsu Ide, David B. Seligson, Sanaz Memarzadeh, Li Xin, Steve Horvath, Purnima Dubey, Maryann B. Flick, Barry M. Kacinski, Aarno Palotie, and Owen N. Witte
Proc Natl Acad Sci U S A. 2002 October 29; 99(22): 14404–14409. Published online 2002 October 15. doi: 10.1073/pnas.222537099.
PMCID: PMC137896
Structure of HIV-2 reverse transcriptase at 2.35-Å resolution and the mechanism of resistance to non-nucleoside inhibitors
J. Ren, L. E. Bird, P. P. Chamberlain, G. B. Stewart-Jones, D. I. Stuart, and D. K. Stammers
Proc Natl Acad Sci U S A. 2002 October 29; 99(22): 14410–14415. Published online 2002 October 17. doi: 10.1073/pnas.222366699.
PMCID: PMC137897
Mutations that permit efficient replication of hepatitis C virus RNA in Huh-7 cells prevent productive replication in chimpanzees
Jens Bukh, Thomas Pietschmann, Volker Lohmann, Nicole Krieger, Kristina Faulk, Ronald E. Engle, Sugantha Govindarajan, Max Shapiro, Marisa St. Claire, and Ralf Bartenschlager
Proc Natl Acad Sci U S A. 2002 October 29; 99(22): 14416–14421. Published online 2002 October 21. doi: 10.1073/pnas.212532699.
PMCID: PMC137898
Microbiology
The genome sequence of Bifidobacterium longum reflects its adaptation to the human gastrointestinal tract
Mark A. Schell, Maria Karmirantzou, Berend Snel, David Vilanova, Bernard Berger, Gabriella Pessi, Marie-Camille Zwahlen, Frank Desiere, Peer Bork, Michele Delley, R. David Pridmore, and Fabrizio Arigoni
Proc Natl Acad Sci U S A. 2002 October 29; 99(22): 14422–14427. Published online 2002 October 15. doi: 10.1073/pnas.212527599.
PMCID: PMC137899
Biological activity of the Helicobacter pylori virulence factor CagA is determined by variation in the tyrosine phosphorylation sites
Hideaki Higashi, Ryouhei Tsutsumi, Akiko Fujita, Shiho Yamazaki, Masahiro Asaka, Takeshi Azuma, and Masanori Hatakeyama
Proc Natl Acad Sci U S A. 2002 October 29; 99(22): 14428–14433. Published online 2002 October 21. doi: 10.1073/pnas.222375399.
PMCID: PMC137900
Genome sequence of Streptococcus mutans UA159, a cariogenic dental pathogen
Dragana Ajdić, William M. McShan, Robert E. McLaughlin, Gorana Savić, Jin Chang, Matthew B. Carson, Charles Primeaux, Runying Tian, Steve Kenton, Honggui Jia, Shaoping Lin, Yudong Qian, Shuling Li, Hua Zhu, Fares Najar, Hongshing Lai, Jim White, Bruce A. Roe, and Joseph J. Ferretti
Proc Natl Acad Sci U S A. 2002 October 29; 99(22): 14434–14439. Published online 2002 October 23. doi: 10.1073/pnas.172501299.
PMCID: PMC137901
A synthetic HIV-1 Rev inhibitor interfering with the CRM1-mediated nuclear export
Dirk Daelemans, Elena Afonina, Jakob Nilsson, Gudrun Werner, Jørgen Kjems, Erik De Clercq, George N. Pavlakis, and Anne-Mieke Vandamme
Proc Natl Acad Sci U S A. 2002 October 29; 99(22): 14440–14445. Published online 2002 October 9. doi: 10.1073/pnas.212285299.
PMCID: PMC137902
Bradyoxetin, a unique chemical signal involved in symbiotic gene regulation
John Loh, Russell W. Carlson, William S. York, and Gary Stacey
Proc Natl Acad Sci U S A. 2002 October 29; 99(22): 14446–14451. Published online 2002 October 22. doi: 10.1073/pnas.222336799.
PMCID: PMC137903
Neuroscience
Alleles at the Nicastrin locus modify presenilin 1- deficiency phenotype
Richard Rozmahel, Howard T. J. Mount, Fusheng Chen, Van Nguyen, Jean Huang, Serap Erdebil, Jennifer Liauw, Gang Yu, Hiroshe Hasegawa, YongJun Gu, You-Qiang Song, Stephen D. Schmidt, Ralph A. Nixon, Paul M. Mathews, Catherine Bergeron, Paul Fraser, David Westaway, and Peter St George-Hyslop
Proc Natl Acad Sci U S A. 2002 October 29; 99(22): 14452–14457. Published online 2002 October 18. doi: 10.1073/pnas.222413999.
PMCID: PMC137904
Multiple spatiotemporal modes of actin reorganization by NMDA receptors and voltage-gated Ca2+ channels
Tomoyuki Furuyashiki, Yoshiki Arakawa, Sayaka Takemoto-Kimura, Haruhiko Bito, and Shuh Narumiya
Proc Natl Acad Sci U S A. 2002 October 29; 99(22): 14458–14463. Published online 2002 October 21. doi: 10.1073/pnas.212148999.
PMCID: PMC137905
A family of RIM-binding proteins regulated by alternative splicing: Implications for the genesis of synaptic active zones
Yun Wang, Xinran Liu, Thomas Biederer, and Thomas C. Südhof
Proc Natl Acad Sci U S A. 2002 October 29; 99(22): 14464–14469. Published online 2002 October 21. doi: 10.1073/pnas.182532999.
PMCID: PMC137906
Internalization and recycling of 5-HT2A receptors activated by serotonin and protein kinase C-mediated mechanisms
Samarjit Bhattacharyya, Sapna Puri, Ricardo Miledi, and Mitradas M. Panicker
Proc Natl Acad Sci U S A. 2002 October 29; 99(22): 14470–14475. Published online 2002 October 18. doi: 10.1073/pnas.212517999.
PMCID: PMC137907
Impaired recycling of synaptic vesicles after acute perturbation of the presynaptic actin cytoskeleton
Oleg Shupliakov, Ona Bloom, Jenny S. Gustafsson, Ole Kjaerulff, Peter Löw, Nikolay Tomilin, Vincent A. Pieribone, Paul Greengard, and Lennart Brodin
Proc Natl Acad Sci U S A. 2002 October 29; 99(22): 14476–14481. Published online 2002 October 15. doi: 10.1073/pnas.212381799.
PMCID: PMC137908
A probabilistic explanation of brightness scaling
Surajit Nundy and Dale Purves
Proc Natl Acad Sci U S A. 2002 October 29; 99(22): 14482–14487. Published online 2002 October 18. doi: 10.1073/pnas.172520399.
PMCID: PMC137909
The identification of vesicular glutamate transporter 3 suggests novel modes of signaling by glutamate
Robert T. Fremeau, Jr., Jonathon Burman, Tayyaba Qureshi, Cindy H. Tran, John Proctor, Juliette Johnson, Hui Zhang, David Sulzer, David R. Copenhagen, Jon Storm-Mathisen, Richard J. Reimer, Farrukh A. Chaudhry, and Robert H. Edwards
Proc Natl Acad Sci U S A. 2002 October 29; 99(22): 14488–14493. Published online 2002 October 18. doi: 10.1073/pnas.222546799.
PMCID: PMC137910
Two different inward rectifier K+ channels are effectors for transmitter-induced slow excitation in brain neurons
D. Bajic, M. Koike, A. M. Albsoul-Younes, S. Nakajima, and Y. Nakajima
Proc Natl Acad Sci U S A. 2002 October 29; 99(22): 14494–14499. Published online 2002 October 21. doi: 10.1073/pnas.222379999.
PMCID: PMC137911
Overexpression of motor protein KIF17 enhances spatial and working memory in transgenic mice
Richard Wing-Chuen Wong, Mitsutoshi Setou, Junlin Teng, Yosuke Takei, and Nobutaka Hirokawa
Proc Natl Acad Sci U S A. 2002 October 29; 99(22): 14500–14505. Published online 2002 October 21. doi: 10.1073/pnas.222371099.
PMCID: PMC137912
Neural stem cell heterogeneity demonstrated by molecular phenotyping of clonal neurospheres
Oleg N. Suslov, Valery G. Kukekov, Tatyana N. Ignatova, and Dennis A. Steindler
Proc Natl Acad Sci U S A. 2002 October 29; 99(22): 14506–14511. Published online 2002 October 15. doi: 10.1073/pnas.212525299.
PMCID: PMC137913
Bidirectional plasticity of excitatory postsynaptic potential (EPSP)-spike coupling in CA1 hippocampal pyramidal neurons
Gaël Daoudal, Yasuhiro Hanada, and Dominique Debanne
Proc Natl Acad Sci U S A. 2002 October 29; 99(22): 14512–14517. Published online 2002 October 21. doi: 10.1073/pnas.222546399.
PMCID: PMC137914
The role of ipsilateral premotor cortex in hand movement after stroke
Heidi Johansen-Berg, Matthew F. S. Rushworth, Marko D. Bogdanovic, Udo Kischka, Sunil Wimalaratna, and Paul M. Matthews
Proc Natl Acad Sci U S A. 2002 October 29; 99(22): 14518–14523. Published online 2002 October 10. doi: 10.1073/pnas.222536799.
PMCID: PMC137915
From the Cover:
Resistance of α-synuclein null mice to the parkinsonian neurotoxin MPTP
William Dauer, Nikolai Kholodilov, Miquel Vila, Anne-Cecile Trillat, Rose Goodchild, Kristin E. Larsen, Roland Staal, Kim Tieu, Yvonne Schmitz, Chao Annie Yuan, Marcelo Rocha, Vernice Jackson-Lewis, Steven Hersch, David Sulzer, Serge Przedborski, Robert Burke, and Rene Hen
Proc Natl Acad Sci U S A. 2002 October 29; 99(22): 14524–14529. Published online 2002 October 10. doi: 10.1073/pnas.172514599.
PMCID: PMC137916
Control of lactotrop proliferation by dopamine: Essential role of signaling through D2 receptors and ERKs
Ciro Iaccarino, Tarek A. Samad, Carole Mathis, Henri Kercret, Roberto Picetti, and Emiliana Borrelli
Proc Natl Acad Sci U S A. 2002 October 29; 99(22): 14530–14535. Published online 2002 October 21. doi: 10.1073/pnas.222319599.
PMCID: PMC137917
A GDP/GTP exchange protein for the Rab3 small G protein family up-regulates a postdocking step of synaptic exocytosis in central synapses
Kazuhiko Yamaguchi, Miki Tanaka, Akira Mizoguchi, Yoshihiro Hirata, Hiroyoshi Ishizaki, Kumi Kaneko, Jun Miyoshi, and Yoshimi Takai
Proc Natl Acad Sci U S A. 2002 October 29; 99(22): 14536–14541. Published online 2002 October 18. doi: 10.1073/pnas.212511399.
PMCID: PMC137918
Cofactors of serine racemase that physiologically stimulate the synthesis of the N-methyl-d-aspartate (NMDA) receptor coagonist d-serine
Joari de Miranda, Rogerio Panizzutti, Veronika N. Foltyn, and Herman Wolosker
Proc Natl Acad Sci U S A. 2002 October 29; 99(22): 14542–14547. Published online 2002 October 22. doi: 10.1073/pnas.222421299.
PMCID: PMC137919
Pharmacology
From the Cover:
Selenomethionine regulation of p53 by a ref1-dependent redox mechanism
Young R. Seo, Mark R. Kelley, and Martin L. Smith
Proc Natl Acad Sci U S A. 2002 October 29; 99(22): 14548–14553. Published online 2002 September 30. doi: 10.1073/pnas.212319799.
PMCID: PMC137920
A Drosophila dopamine 2-like receptor: Molecular characterization and identification of multiple alternatively spliced variants
Mark G. Hearn, Yong Ren, Edward W. McBride, Isabelle Reveillaud, Martin Beinborn, and Alan S. Kopin
Proc Natl Acad Sci U S A. 2002 October 29; 99(22): 14554–14559. Published online 2002 October 21. doi: 10.1073/pnas.202498299.
PMCID: PMC137921
Physiology
Coupling of c-Src to large conductance voltage- and Ca2+-activated K+ channels as a new mechanism of agonist-induced vasoconstriction
Abderrahmane Alioua, Aman Mahajan, Kazuhide Nishimaru, Masoud M. Zarei, Enrico Stefani, and Ligia Toro
Proc Natl Acad Sci U S A. 2002 October 29; 99(22): 14560–14565. Published online 2002 October 21. doi: 10.1073/pnas.222348099.
PMCID: PMC137922
Nicotinic acid-adenine dinucleotide phosphate-sensitive calcium stores initiate insulin signaling in human beta cells
James D. Johnson and Stanley Misler
Proc Natl Acad Sci U S A. 2002 October 29; 99(22): 14566–14571. Published online 2002 October 15. doi: 10.1073/pnas.222099799.
PMCID: PMC137923
Na pump isoforms in human erythroid progenitor cells and mature erythrocytes
Joseph F. Hoffman, Amittha Wickrema, Olga Potapova, Mark Milanick, and Douglas R. Yingst
Proc Natl Acad Sci U S A. 2002 October 29; 99(22): 14572–14577. Published online 2002 October 18. doi: 10.1073/pnas.222539999.
PMCID: PMC137924
Plant Biology
Bottlenecks for metabolic engineering of isoflavone glycoconjugates in Arabidopsis
Chang-Jun Liu, Jack W. Blount, Christopher L. Steele, and Richard A. Dixon
Proc Natl Acad Sci U S A. 2002 October 29; 99(22): 14578–14583. Published online 2002 October 16. doi: 10.1073/pnas.212522099.
PMCID: PMC137925
Interphase chromosomes in Arabidopsis are organized as well defined chromocenters from which euchromatin loops emanate
Paul Fransz, J. Hans de Jong, Martin Lysak, Monica Ruffini Castiglione, and Ingo Schubert
Proc Natl Acad Sci U S A. 2002 October 29; 99(22): 14584–14589. Published online 2002 October 16. doi: 10.1073/pnas.212325299.
PMCID: PMC137926
Population Biology
Wind-dispersed pollen mediates postglacial gene flow among refugia
Sascha Liepelt, Ronald Bialozyt, and Birgit Ziegenhagen
Proc Natl Acad Sci U S A. 2002 October 29; 99(22): 14590–14594. Published online 2002 October 21. doi: 10.1073/pnas.212285399.
PMCID: PMC137927
Psychology (Biological Sciences)
Fractionating the neural substrate of cognitive control processes
Jean-Claude Dreher and Karen Faith Berman
Proc Natl Acad Sci U S A. 2002 October 29; 99(22): 14595–14600. Published online 2002 October 21. doi: 10.1073/pnas.222193299.
PMCID: PMC137928
Auditory system: Peripheral nonlinearity and central additivity, as revealed in the human stapedius-muscle reflex
Jozef J. Zwislocki
Proc Natl Acad Sci U S A. 2002 October 29; 99(22): 14601–14606. Published online 2002 October 18. doi: 10.1073/pnas.222543199.
PMCID: PMC137929
Social Sciences
Psychology
Estimating physical reflectance spectra from human color-matching experiments
A. Kimball Romney and Tarow Indow
Proc Natl Acad Sci U S A. 2002 October 29; 99(22): 14607–14610. Published online 2002 October 18. doi: 10.1073/pnas.222558899.
PMCID: PMC137930
Corrections
Proc Natl Acad Sci U S A. 2002 October 29; 99(22): 14611. Published online 2002 October 24. doi: 10.1073/pnas.222517899.
PMCID: PMC137816
Corrects: Brian C. Schutte, et al. Discovery of five conserved β-defensin gene clusters using a computational search strategy. Proc Natl Acad Sci U S A. 2002 February 19; 99(4): 2129–2133.
Proc Natl Acad Sci U S A. 2002 October 29; 99(22): 14611. Published online 2002 October 10. doi: 10.1073/pnas.222515799.
PMCID: PMC137817
Corrects: Julius C. R. Hafalla, et al. Short-term antigen presentation and single clonal burst limit the magnitude of the CD8+ T cell responses to malaria liver stages. Proc Natl Acad Sci U S A. 2002 September 3; 99(18): 11819–11824.
Other Issues:  previous | next | latest | archive