| | This journal provides immediate access to some articles. Editorial PNAS publishes daily online Nicholas R. Cozzarelli, Kenneth R. Fulton, and Diane M. Sullenberger PMCID: PMC123093 Commentaries The COXes of Danio: From mechanistic model to experimental therapeutics Stephen M. Prescott and H. Joseph Yost PMCID: PMC123094 Shooting from the hip: Spatial control of signal release by intracellular waves Stanislav Y. Shvartsman PMCID: PMC123095 Plant receptor kinases: Systemin receptor identified Yanhai Yin, Dongying Wu, and Joanne Chory PMCID: PMC123096 Exceptional haplotype variation in maize Jeffrey L. Bennetzen and Wusirika Ramakrishna PMCID: PMC123097 The search for new ways to treat obesity Jules Hirsch PMCID: PMC123098 Progress toward an ultimate proof of the prion hypothesis Susan W. Liebman PMCID: PMC123099 Physical Sciences Chemistry 1H and 13C MAS NMR evidence for pronounced ligand–protein interactions involving the ionone ring of the retinylidene chromophore in rhodopsin Alain F. L. Creemers, Suzanne Kiihne, Petra H. M. Bovee-Geurts, Willem J. DeGrip, Johan Lugtenburg, and Huub J. M. de Groot PMCID: PMC123100 Beyond the Rayleigh instability limit for multicharged finite systems: From fission to Coulomb explosion Isidore Last, Yaakov Levy, and Joshua Jortner PMCID: PMC123101 Geology Diffuse fluid flux through orogenic belts: Implications for the world ocean Steven E. Ingebritsen and Craig E. Manning PMCID: PMC123102 Atomic force microscopy of Precambrian microscopic fossils André Kempe, J. William Schopf, Wladyslaw Altermann, Anatoliy B. Kudryavtsev, and Wolfgang M. Heckl PMCID: PMC123103 Statistics From the Cover:
Cluster analysis of gene expression dynamics Marco F. Ramoni, Paola Sebastiani, and Isaac S. Kohane PMCID: PMC123104 Biological Sciences Biochemistry High-resolution structures of a chitinase complexed with natural product cyclopentapeptide inhibitors: Mimicry of carbohydrate substrate Douglas R. Houston, Kazuro Shiomi, Noriko Arai, Satoshi Ōmura, Martin G. Peter, Andreas Turberg, Bjørnar Synstad, Vincent G. H. Eijsink, and Daan M. F. van Aalten PMCID: PMC123105 The fifth essential DNA polymerase ![[var phi]](corehtml/pmc/pmcents/x03C6.gif) in Saccharomyces cerevisiae is localized to the nucleolus and plays an important role in synthesis of rRNA Kikuo Shimizu, Yasuo Kawasaki, Shin-Ichiro Hiraga, Maki Tawaramoto, Naomi Nakashima, and Akio Sugino PMCID: PMC123106 Potent stimulation of transcription-coupled DNA supercoiling by sequence-specific DNA-binding proteins Fenfei Leng and Roger McMacken PMCID: PMC123107 Distinct domains of splicing factor Prp8 mediate different aspects of spliceosome activation Andreas N. Kuhn, Elizabeth M. Reichl, and David A. Brow PMCID: PMC123108 Direct detection of potential selenium delivery proteins by using an Escherichia coli strain unable to incorporate selenium from selenite into proteins Gerard M. Lacourciere, Rodney L. Levine, and Thressa C. Stadtman PMCID: PMC123109 A ribozyme that ligates RNA to protein Scott Baskerville and David P. Bartel PMCID: PMC123110 Pheromone induction promotes Ste11 degradation through a MAPK feedback and ubiquitin-dependent mechanism R. K. Esch and B. Errede PMCID: PMC123111 The final acylation step in Taxol biosynthesis: Cloning of the taxoid C13-side-chain N-benzoyltransferase from Taxus Kevin Walker, Robert Long, and Rodney Croteau PMCID: PMC123112 Evidence for S-nitrosothiol-dependent changes in fibrinogen that do not involve transnitrosation or thiolation Shirin Akhter, Arianna Vignini, Zhong Wen, Ann English, Peng G. Wang, and Bulent Mutus PMCID: PMC123113 Transcription and replication initiate at separate sites on the vesicular stomatitis virus genome Sean P. J. Whelan and Gail W. Wertz PMCID: PMC123114 Biophysics Three-dimensional structure of the amino-terminal domain of syntaxin 6, a SNAP-25 C homolog Kira M. S. Misura, Jason B. Bock, Lino C. Gonzalez, Jr., Richard H. Scheller, and William I. Weis PMCID: PMC123115 Polyproline II structure in a sequence of seven alanine residues Zhengshuang Shi, C. Anders Olson, George D. Rose, Robert L. Baldwin, and Neville R. Kallenbach PMCID: PMC123116 The protofilament structure of insulin amyloid fibrils José L. Jiménez, Ewan J. Nettleton, Mario Bouchard, Carol V. Robinson, Christopher M. Dobson, and Helen R. Saibil PMCID: PMC123117 Conformational change of the actomyosin complex drives the multiple stepping movement Tomoki P. Terada, Masaki Sasai, and Tetsuya Yomo PMCID: PMC123118 From the Cover:
Apparent role of traveling metabolic waves in oxidant release by living neutrophils Andrei L. Kindzelskii and Howard R. Petty PMCID: PMC123119 Cell Biology A protein kinase B-dependent and rapamycin-sensitive pathway controls skeletal muscle growth but not fiber type specification Giorgia Pallafacchina, Elisa Calabria, Antonio L. Serrano, John M. Kalhovde, and Stefano Schiaffino PMCID: PMC123120 Interactions between Eph kinases and ephrins provide a mechanism to support platelet aggregation once cell-to-cell contact has occurred Nicolas Prevost, Donna Woulfe, Takako Tanaka, and Lawrence F. Brass PMCID: PMC123121 The ryanodine receptor modulates the spontaneous beating rate of cardiomyocytes during development Huang-Tian Yang, David Tweedie, Su Wang, Antonio Guia, Tatiana Vinogradova, Konstantin Bogdanov, Paul D. Allen, Michael D. Stern, Edward G. Lakatta, and Kenneth R. Boheler PMCID: PMC123122 Polyvalent cation receptor proteins (CaRs) are salinity sensors in fish J. Nearing, M. Betka, S. Quinn, H. Hentschel, M. Elger, M. Baum, M. Bai, N. Chattopadyhay, E. M. Brown, S. C. Hebert, and H. W. Harris PMCID: PMC123123 Developmental Biology GATA-factor dependence of the multitype zinc-finger protein FOG-1 for its essential role in megakaryopoiesis Aaron N. Chang, Alan B. Cantor, Yuko Fujiwara, Maya B. Lodish, Steven Droho, John D. Crispino, and Stuart H. Orkin PMCID: PMC123124 Promoter-proximal tethering elements regulate enhancer-promoter specificity in the Drosophila Antennapedia complex Vincent C. Calhoun, Angelike Stathopoulos, and Michael Levine PMCID: PMC123125 Erk5 null mice display multiple extraembryonic vascular and embryonic cardiovascular defects Christopher P. Regan, Wei Li, Diane M. Boucher, Stephen Spatz, Michael S. Su, and Keisuke Kuida PMCID: PMC123126 SKIP is an indispensable factor for Caenorhabditis elegans development Marta Kostrouchova, Daniel Housa, Zdenek Kostrouch, Vladimir Saudek, and Joseph Edward Rall PMCID: PMC123127 PRKX, a phylogenetically and functionally distinct cAMP-dependent protein kinase, activates renal epithelial cell migration and morphogenesis Xiaohong Li, Hsi-Ping Li, Kurt Amsler, Deborah Hyink, Patricia D. Wilson, and Christopher R. Burrow PMCID: PMC123128 Ecology Tracking the ecological overshoot of the human
economy Mathis Wackernagel, Niels B. Schulz, Diana Deumling, Alejandro Callejas Linares, Martin Jenkins, Valerie Kapos, Chad Monfreda, Jonathan Loh, Norman Myers, Richard Norgaard, and Jørgen Randers PMCID: PMC123129 Evolution Gene order evolution and paleopolyploidy in hemiascomycete yeasts Simon Wong, Geraldine Butler, and Kenneth H. Wolfe PMCID: PMC123130 Ancestral polymorphism and adaptive evolution in the trichothecene mycotoxin gene cluster of phytopathogenic Fusarium Todd J. Ward, Joseph P. Bielawski, H. Corby Kistler, Eileen Sullivan, and Kerry O'Donnell PMCID: PMC123131 Population genomics of drug resistance in Candida albicans Leah E. Cowen, André Nantel, Malcolm S. Whiteway, David Y. Thomas, Daniel C. Tessier, Linda M. Kohn, and James B. Anderson PMCID: PMC123132 From the Cover:
Overt female mate competition and preference for central males in a lekking antelope Jakob Bro-Jørgensen PMCID: PMC123133 Second- and third-hand chloroplasts in dinoflagellates: Phylogeny of oxygen-evolving enhancer 1 (PsbO) protein reveals replacement of a nuclear-encoded plastid gene by that of a haptophyte tertiary endosymbiont Ken-ichiro Ishida and Beverley R. Green PMCID: PMC123134 Genetics From the Cover:
Cluster analysis of gene expression dynamics Marco F. Ramoni, Paola Sebastiani, and Isaac S. Kohane PMCID: PMC123104 Association of a lysine-232/alanine polymorphism in a bovine gene encoding acyl-CoA:diacylglycerol acyltransferase (DGAT1) with variation at a quantitative trait locus for milk fat content Andreas Winter, Wolfgang Krämer, Fabian A. O. Werner, Sonja Kollers, Srinivas Kata, Gregor Durstewitz, Johannes Buitkamp, James E. Womack, Georg Thaller, and Ruedi Fries PMCID: PMC123135 Maternal transmission of P element transposase activity in Drosophila melanogaster depends on the last P intron Michael J. Simmons, Kevin J. Haley, and Sarah J. Thompson PMCID: PMC123136 Live-cell imaging reveals divergent intracellular dynamics of polyglutamine disease proteins and supports a sequestration model of pathogenesis Yaohui Chai, Jianqiang Shao, Victor M. Miller, Aislinn Williams, and Henry L. Paulson PMCID: PMC123137 The genome-wide expression response to telomerase deletion in Saccharomyces cerevisiae Shivani Nautiyal, Joseph L. DeRisi, and Elizabeth H. Blackburn PMCID: PMC123138 Positional cloning of the murine flavivirus resistance gene Andrey A. Perelygin, Svetlana V. Scherbik, Igor B. Zhulin, Bronislava M. Stockman, Yan Li, and Margo A. Brinton PMCID: PMC123139 The barley stem rust-resistance gene Rpg1 is a novel disease-resistance gene with homology to receptor kinases R. Brueggeman, N. Rostoks, D. Kudrna, A. Kilian, F. Han, J. Chen, A. Druka, B. Steffenson, and A. Kleinhofs PMCID: PMC123140 Identification and characterization of CIA/ASF1 as an interactor of bromodomains associated with TFIID Takahiko Chimura, Takashi Kuzuhara, and Masami Horikoshi PMCID: PMC123141 Hyporesponsiveness of SPRET/Ei mice to lethal shock induced by tumor necrosis factor and implications for a TNF-based antitumor therapy Jan Staelens, Ben Wielockx, Leen Puimège, Frans Van Roy, Jean-Louis Guénet, and Claude Libert PMCID: PMC123142 An approach for global scanning of single nucleotide variations Xinghua Pan and Sherman M. Weissman PMCID: PMC123143 Interaction of Gα12 with Gα13 and Gαq signaling pathways Jennifer L. Gu, Stefan Müller, Valeria Mancino, Stefan Offermanns, and Melvin I. Simon PMCID: PMC123144 Immunology Cytotoxic T lymphocytes directed against a tumor-specific mutated antigen display similar HLA tetramer binding but distinct functional avidity and tissue distribution Hamid Echchakir, Guillaume Dorothée, Isabelle Vergnon, Jeanne Menez, Salem Chouaib, and Fathia Mami-Chouaib PMCID: PMC123145 GATA-3 transcriptional imprinting in Th2 lymphocytes: A mathematical model Thomas Höfer, Holger Nathansen, Max Löhning, Andreas Radbruch, and Reinhart Heinrich PMCID: PMC123146 CD28 plays a critical role in the segregation of PKCθ within the immunologic synapse Jianyong Huang, Pei-Fen Lo, Tomasz Żal, Nicholas R. J. Gascoigne, Brian A. Smith, Steven D. Levin, and Howard M. Grey PMCID: PMC123147 Restricted islet-cell reactive T cell repertoire of early pancreatic islet infiltrates in NOD mice Felix J. Baker, Mark Lee, Yueh-hsiu Chien, and Mark M. Davis PMCID: PMC123148 HIV envelope induces a cascade of cell signals in non-proliferating target cells that favor virus replication Claudia Cicala, James Arthos, Sara M. Selig, Glynn Dennis, Jr., Douglas A. Hosack, Donald Van Ryk, Marion L. Spangler, Tavis D. Steenbeke, Prateeti Khazanie, Neil Gupta, Jun Yang, Marybeth Daucher, Richard A. Lempicki, and Anthony S. Fauci PMCID: PMC123149 Role of NFκB activator Act1 in CD40-mediated signaling in epithelial cells Youcun Qian, Zhendong Zhao, Zhengfan Jiang, and Xiaoxia Li PMCID: PMC123150 Uncoupling protein 2 plays an important role in nitric oxide production of lipopolysaccharide-stimulated macrophages Takako Kizaki, Kenji Suzuki, Yoshiaki Hitomi, Naoyuki Taniguchi, Daizoh Saitoh, Kenji Watanabe, Kazunori Onoé, Noorbibi K. Day, Robert A. Good, and Hideki Ohno PMCID: PMC123151 Defective T cell development and function in calcineurin Aβ-deficient mice Orlando F. Bueno, Eric B. Brandt, Marc E. Rothenberg, and Jeffery D. Molkentin PMCID: PMC123152 Crystal structure of human cytomegalovirus IL-10 bound to soluble human IL-10R1 Brandi C. Jones, Naomi J. Logsdon, Kristopher Josephson, Jennifer Cook, Peter A. Barry, and Mark R. Walter PMCID: PMC123153 Transepithelial transport of HIV-1 by M cells is receptor-mediated Grigorios Fotopoulos, Alexandre Harari, Pierre Michetti, Didier Trono, Giuseppe Pantaleo, and Jean-Pierre Kraehenbuhl PMCID: PMC123154 Human tumor-derived genomic DNA transduced into a recipient cell induces tumor-specific immune responses ex vivo Theresa L. Whiteside, Andrea Gambotto, Andreas Albers, Joanna Stanson, and Edward P. Cohen PMCID: PMC123155 Direct visualization of distinct T cell epitopes derived from a melanoma tumor-associated antigen by using human recombinant antibodies with MHC- restricted T cell receptor-like specificity Galit Denkberg, Cyril J. Cohen, Avital Lev, Patrick Chames, Hennie R. Hoogenboom, and Yoram Reiter PMCID: PMC123156 Medical Sciences An estrogen receptor repressor induces cataract formation in transgenic mice Vicki L. Davis, Chi-Chao Chan, Timothy J. Schoen, John F. Couse, Gerald J. Chader, and Kenneth S. Korach PMCID: PMC123157 Mutations in APC, Kirsten-ras, and p53—alternative genetic pathways to colorectal cancer Gillian Smith, Francis A. Carey, Julie Beattie, Murray J. V. Wilkie, Tracy J. Lightfoot, Jonathan Coxhead, R. Colin Garner, Robert J. C. Steele, and C. Roland Wolf PMCID: PMC123158 Interaction of intracellular β amyloid peptide with chaperone proteins Virginia Fonte, Vadim Kapulkin, Andrew Taft, Amy Fluet, David Friedman, and Christopher D. Link PMCID: PMC123159 Tissue-nonspecific alkaline phosphatase and plasma cell membrane glycoprotein-1 are central antagonistic regulators of bone mineralization Lovisa Hessle, Kristen A. Johnson, H. Clarke Anderson, Sonoko Narisawa, Adnan Sali, James W. Goding, Robert Terkeltaub, and José Luis Millán PMCID: PMC123160 Recombinant human erythropoietin counteracts secondary injury and markedly enhances neurological recovery from experimental spinal cord trauma Alfredo Gorio, Necati Gokmen, Serhat Erbayraktar, Osman Yilmaz, Laura Madaschi, Cinzia Cichetti, Anna Maria Di Giulio, Enver Vardar, Anthony Cerami, and Michael Brines PMCID: PMC123161 Chimeric snRNA molecules carrying antisense sequences against the splice junctions of exon 51 of the dystrophin pre-mRNA induce exon skipping and restoration of a dystrophin synthesis in Δ48-50 DMD cells Fernanda Gabriella De Angelis, Olga Sthandier, Barbara Berarducci, Silvia Toso, Giuliana Galluzzi, Enzo Ricci, Giulio Cossu, and Irene Bozzoni PMCID: PMC123162 VEGF receptor 2 and the adherens junction as a mechanical transducer in vascular endothelial cells Ayelet Shay-Salit, Moran Shushy, Efrat Wolfovitz, Hava Yahav, Ferruccio Breviario, Elisabetta Dejana, and Nitzan Resnick PMCID: PMC123163 Adaptive immunity cooperates with liposomal all-trans-retinoic acid (ATRA) to facilitate long-term molecular remissions in mice with acute promyelocytic leukemia Peter Westervelt, Jessica L. Pollock, Kristie M. Oldfather, Matthew J. Walter, Margaret K. Ma, Anthony Williams, John F. DiPersio, and Timothy J. Ley PMCID: PMC123164 Knockout of the α1A/C-adrenergic receptor subtype: The α1A/C is expressed in resistance arteries and is required to maintain arterial blood pressure D. Gregg Rokosh and Paul C. Simpson PMCID: PMC123165 Adeno-associated viral vector-mediated hypoxia response element-regulated gene expression in mouse ischemic heart model Hua Su, Janice Arakawa-Hoyt, and Yuet Wai Kan PMCID: PMC123166 Randomized controlled trial of a treatment for anorexia and bulimia nervosa Cecilia Bergh, Ulf Brodin, Greger Lindberg, and Per Södersten PMCID: PMC123167 Apoptotic threshold is lowered by p53 transactivation of caspase-6 Timothy K. MacLachlan and Wafik S. El-Deiry PMCID: PMC123168 C75 increases peripheral energy utilization and fatty acid oxidation in diet-induced obesity Jagan N. Thupari, Leslie E. Landree, Gabriele V. Ronnett, and Francis P. Kuhajda PMCID: PMC123169 Evidence for a cytopathogenicity determinant in HIV-1 Vpr Mohan Somasundaran, Mark Sharkey, Beda Brichacek, Katherine Luzuriaga, Michael Emerman, John L. Sullivan, and Mario Stevenson PMCID: PMC123170 Microbiology The complete genome sequence of Chlorobium tepidum TLS, a photosynthetic, anaerobic, green-sulfur bacterium Jonathan A. Eisen, Karen E. Nelson, Ian T. Paulsen, John F. Heidelberg, Martin Wu, Robert J. Dodson, Robert Deboy, Michelle L. Gwinn, William C. Nelson, Daniel H. Haft, Erin K. Hickey, Jeremy D. Peterson, A. Scott Durkin, James L. Kolonay, Fan Yang, Ingeborg Holt, Lowell A. Umayam, Tanya Mason, Michael Brenner, Terrance P. Shea, Debbie Parksey, William C. Nierman, Tamara V. Feldblyum, Cheryl L. Hansen, M. Brook Craven, Diana Radune, Jessica Vamathevan, Hoda Khouri, Owen White, Tanja M. Gruber, Karen A. Ketchum, J. Craig Venter, Hervé Tettelin, Donald A. Bryant, and Claire M. Fraser PMCID: PMC123171 Mutations in the RNase H domain of HIV-1 reverse transcriptase affect the initiation of DNA synthesis and the specificity of RNase H cleavage in vivo John G. Julias, Mary Jane McWilliams, Stefan G. Sarafianos, Edward Arnold, and Stephen H. Hughes PMCID: PMC123172 Neurobiology Effects of cerebral ischemia in mice deficient in Persephin Andreas C. Tomac, Alan D. Agulnick, Norman Haughey, Chen-Fu Chang, Yajun Zhang, Cristina Bäckman, Marisela Morales, Mark P. Mattson, Yun Wang, Heiner Westphal, and Barry J. Hoffer PMCID: PMC123173 The relationship between cortical activation and perception investigated with invisible stimuli K. Moutoussis and S. Zeki PMCID: PMC123174 Cortical hyperpolarization-activated depolarizing current takes part in the generation of focal paroxysmal activities Igor Timofeev, Maxim Bazhenov, Terrence Sejnowski, and Mircea Steriade PMCID: PMC123175 Assessing the role of Ih channels in synaptic transmission and mossy fiber LTP Vivien Chevaleyre and Pablo E. Castillo PMCID: PMC123176 Physiology Nuclear KATP channels trigger nuclear Ca2+ transients that modulate nuclear function Ivan Quesada, Juan M. Rovira, Franz Martin, Enrique Roche, Angel Nadal, and Bernat Soria PMCID: PMC123177 Oxytocin induces differentiation of P19 embryonic stem cells to cardiomyocytes Joanne Paquin, Bogdan A. Danalache, Marek Jankowski, Samuel M. McCann, and Jolanta Gutkowska PMCID: PMC123178 Role of the short isoform of myosin light chain kinase in the contraction of cultured smooth muscle cells as examined by its down-regulation Jianjun Bao, Kazuhiko Oishi, Tomohisa Yamada, Liqun Liu, Akio Nakamura, Masaatsu K. Uchida, and Kazuhiro Kohama PMCID: PMC123179 Influence of the period-dependent circadian clock on diurnal, circadian, and aperiodic gene expression in Drosophila melanogaster Yiing Lin, Mei Han, Brian Shimada, Lin Wang, Therese M. Gibler, Aloka Amarakone, Tarif A. Awad, Gary D. Stormo, Russell N. Van Gelder, and Paul H. Taghert PMCID: PMC123180 Plant Biology Assaying gene content in Arabidopsis Keith D. Allen PMCID: PMC123181 From the Cover:
Intraspecific violation of genetic colinearity and its implications in maize Huihua Fu and Hugo K. Dooner PMCID: PMC123182 Selective interaction of plant homeodomain proteins mediates high DNA-binding affinity Harley M. S. Smith, Ilja Boschke, and Sarah Hake PMCID: PMC123183 From the Cover:
The systemin receptor SR160 from Lycopersicon peruvianum is a member of the LRR receptor kinase family Justin M. Scheer and Clarence A. Ryan, Jr. PMCID: PMC123184 Population Biology The aging baboon: Comparative demography in a non-human primate Anne M. Bronikowski, Susan C. Alberts, Jeanne Altmann, Craig Packer, K. Dee Carey, and Marc Tatar PMCID: PMC123185 Psychology Rapid natural scene categorization in the near absence of attention Fei Fei Li, Rufin VanRullen, Christof Koch, and Pietro Perona PMCID: PMC123186 Social Sciences Psychology Eye contact detection in humans from birth Teresa Farroni, Gergely Csibra, Francesca Simion, and Mark H. Johnson PMCID: PMC123187 Corrections Proc Natl Acad Sci U S A. 2002 July 9; 99(14): 9606. Published online 2002 June 11. doi: 10.1073/pnas.132247499.PMCID: PMC123089 Corrects: Arindam Dasgupta, et al. Mot1 activates and represses transcription by direct, ATPase-dependent mechanisms. Proc Natl Acad Sci U S A. 2002 March 5; 99(5): 2666–2671. Proc Natl Acad Sci U S A. 2002 July 9; 99(14): 9606. Published online 2002 June 11. doi: 10.1073/pnas.132282899.PMCID: PMC123090 Corrects: E. Oroudjev, et al. Segmented nanofibers of spider dragline silk: Atomic force microscopy and single-molecule force spectroscopy. Proc Natl Acad Sci U S A. 2002 April 30; 99(Suppl 2): 6460–6465. Proc Natl Acad Sci U S A. 2002 July 9; 99(14): 9606. doi: 10.1073/pnas.112189299.PMCID: PMC123091 Corrects: Yang D. Teng, et al. Functional recovery following traumatic spinal cord injury mediated by a unique polymer scaffold seeded with neural stem cells. Proc Natl Acad Sci U S A. 2002 March 5; 99(5): 3024–3029. Proc Natl Acad Sci U S A. 2002 July 9; 99(14): 9606. doi: 10.1073/pnas.122199499.PMCID: PMC123092 Corrects: Reisa Sperling, et al. Functional MRI detection of pharmacologically induced
memory impairment. Proc Natl Acad Sci U S A. 2002 January 8; 99(1): 455–460. |
