| | This journal provides immediate access to some articles. Commentaries HIV's response to a CCR5 inhibitor: I'd rather tighten than switch! Joshua M. Farber and Edward A. Berger PMCID: PMC122263 New insights into unwrapping DNA from the nucleosome from a single-molecule optical tweezers method Jeffrey J. Hayes and Jeffrey C. Hansen PMCID: PMC122264 Will embryonic stem cells be a useful source of dopamine neurons for transplant into patients with Parkinson's disease? Curt R. Freed PMCID: PMC122265 Physical Sciences Applied Physical Sciences From the Cover:
Fabrication of aligned microstructures with a single elastomeric stamp Joe Tien, Celeste M. Nelson, and Christopher S. Chen PMCID: PMC122266 Chemistry Biological water at the protein surface: Dynamical solvation probed directly with femtosecond resolution Samir Kumar Pal, Jorge Peon, and Ahmed H. Zewail PMCID: PMC122267 The role of intersection topography in bond selectivity of cis-trans photoisomerization M. Ben-Nun, F. Molnar, K. Schulten, and Todd J. Martínez PMCID: PMC122268 From the Cover:
Top-down mass spectrometry of a 29-kDa protein for characterization of any posttranslational modification to within one residue Siu Kwan Sze, Ying Ge, HanBin Oh, and Fred W. McLafferty PMCID: PMC122269 Geophysics Drainage basins and channel incision on Mars Oded Aharonson, Maria T. Zuber, Daniel H. Rothman, Norbert Schorghofer, and Kelin X. Whipple PMCID: PMC122270 Influence of anthropogenic aerosol on cloud optical depth and albedo shown by satellite measurements and chemical transport modeling Stephen E. Schwartz, Harshvardhan, and Carmen M. Benkovitz PMCID: PMC122271 Glacial meltwater dynamics in coastal waters west of the Antarctic peninsula Heidi M. Dierssen, Raymond C. Smith, and Maria Vernet PMCID: PMC122272 Physics Faceting on 3He crystals H. Alles, A. Babkin, R. Jochemsen, A. Ya. Parshin, I. A. Todoshchenko, and V. Tsepelin PMCID: PMC122273 Biological Sciences Applied Biological Sciences Optimizing bioconversion pathways through systems analysis and metabolic engineering Daniel E. Stafford, Kurt S. Yanagimachi, Philip A. Lessard, Sushil K. Rijhwani, Anthony J. Sinskey, and Gregory Stephanopoulos PMCID: PMC122274 Biochemistry 2′,3′-Cyclic nucleotide 3′-phosphodiesterase: A membrane-bound, microtubule-associated protein and membrane anchor for tubulin Maurizio Bifulco, Chiara Laezza, Stefania Stingo, and J. Wolff PMCID: PMC122275 Retrocyclin: A primate peptide that protects cells from infection by T- and M-tropic strains of HIV-1 Alexander M. Cole, Teresa Hong, Lee Ming Boo, Tung Nguyen, Chengquan Zhao, Greg Bristol, Jerome A. Zack, Alan J. Waring, Otto O. Yang, and Robert I. Lehrer PMCID: PMC122276 Polypeptide release at sense and noncognate stop codons by localized charge-exchange alterations in translational release factors Makiko Uno, Koichi Ito, and Yoshikazu Nakamura PMCID: PMC122277 An NMR approach to structural proteomics Adelinda Yee, Xiaoqing Chang, Antonio Pineda-Lucena, Bin Wu, Anthony Semesi, Brian Le, Theresa Ramelot, Gregory M. Lee, Sudeepa Bhattacharyya, Pablo Gutierrez, Aleksej Denisov, Chang-Hun Lee, John R. Cort, Guennadi Kozlov, Jack Liao, Grzegorz Finak, Limin Chen, David Wishart, Weontae Lee, Lawrence P. McIntosh, Kalle Gehring, Michael A. Kennedy, Aled M. Edwards, and Cheryl H. Arrowsmith PMCID: PMC122278 Solution structure and stability of the anti-sigma factor AsiA: Implications for novel functions Jeffrey L. Urbauer, Mario F. Simeonov, Ramona J. Bieber Urbauer, Karen Adelman, Joshua M. Gilmore, and Edward N. Brody PMCID: PMC122279 Structure of adenylylsulfate reductase from the hyperthermophilic Archaeoglobus fulgidus at 1.6-Å resolution Günter Fritz, Annette Roth, Alexander Schiffer, Thomas Büchert, Gleb Bourenkov, Hans D. Bartunik, Harald Huber, Karl O. Stetter, Peter M. H. Kroneck, and Ulrich Ermler PMCID: PMC122280 Ubiquitin-dependent mechanism regulates rapid turnover of AU-rich cytokine mRNAs Gaurav Laroia, Bedabrata Sarkar, and Robert J. Schneider PMCID: PMC122281 Energetics by NMR: Site-specific binding in a positively cooperative system Gregory P. Tochtrop, Klaus Richter, Changguo Tang, James J. Toner, Douglas F. Covey, and David P. Cistola PMCID: PMC122282 A poxvirus-like type IB topoisomerase family in bacteria Berit Olsen Krogh and Stewart Shuman PMCID: PMC122283 Mechanism of action and NAD+-binding mode revealed by the crystal structure of l-histidinol dehydrogenase João A. R. G. Barbosa, J. Sivaraman, Yunge Li, Robert Larocque, Allan Matte, Joseph D. Schrag, and Miroslaw Cygler PMCID: PMC122284 Targeting protein inactivation through an oligomerization chain reaction Francesco Contegno, Mario Cioce, Pier Giuseppe Pelicci, and Saverio Minucci PMCID: PMC122285 Feeding acetyl-l-carnitine and lipoic acid to old rats significantly improves metabolic function while decreasing oxidative stress Tory M. Hagen, Jiankang Liu, Jens Lykkesfeldt, Carol M. Wehr, Russell T. Ingersoll, Vladimir Vinarsky, James C. Bartholomew, and Bruce N. Ames PMCID: PMC122286 Age-associated mitochondrial oxidative decay: Improvement of carnitine acetyltransferase substrate-binding affinity and activity in brain by feeding old rats acetyl-l- carnitine and/or R-α-lipoic acid Jiankang Liu, David W. Killilea, and Bruce N. Ames PMCID: PMC122287 Forced engagement of a RNA/protein complex by a chemical inducer of dimerization to modulate gene expression Isabelle Harvey, Philippe Garneau, and Jerry Pelletier PMCID: PMC122288 The crystal structure and mutational analysis of a novel RNA-binding domain found in the human Tap nuclear mRNA export factor Dona N. Ho, Glen A. Coburn, Yibin Kang, Bryan R. Cullen, and Millie M. Georgiadis PMCID: PMC122289 The human DnaJ protein, hTid-1, enhances binding of a multimer of the herpes simplex virus type 1 UL9 protein to oris, an origin of viral DNA replication Chi-Yong Eom and I. Robert Lehman PMCID: PMC122290 Regulation of the tyrosine kinase Itk by the peptidyl-prolyl isomerase cyclophilin A Kristine N. Brazin, Robert J. Mallis, D. Bruce Fulton, and Amy H. Andreotti PMCID: PMC122291 Incision of DNA–protein crosslinks by UvrABC nuclease suggests a potential repair pathway involving nucleotide excision repair Irina G. Minko, Yue Zou, and R. Stephen Lloyd PMCID: PMC122292 Human DINB1-encoded DNA polymerase κ is a promiscuous extender of mispaired primer termini M. Todd Washington, Robert E. Johnson, Louise Prakash, and Satya Prakash PMCID: PMC122293 Soybean ENOD40 encodes two peptides that bind to sucrose synthase Horst Röhrig, Jürgen Schmidt, Edvins Miklashevichs, Jeff Schell, and Michael John PMCID: PMC122294 Differential effects of a centrally acting fatty acid synthase inhibitor in lean and obese mice Monica V. Kumar, Teruhiko Shimokawa, Tim R. Nagy, and M. Daniel Lane PMCID: PMC122295 Biophysics Biological water at the protein surface: Dynamical solvation probed directly with femtosecond resolution Samir Kumar Pal, Jorge Peon, and Ahmed H. Zewail PMCID: PMC122267 The carboxyl tail forms a discrete functional domain that blocks closure of the yeast K+ channel Stephen H. Loukin, Junyu Lin, Umair Athar, Christopher Palmer, and Yoshiro Saimi PMCID: PMC122296 RNA hairpin-folding kinetics Wenbing Zhang and Shi-Jie Chen PMCID: PMC122297 A method for optimizing potential-energy functions by a hierarchical design of the potential-energy landscape: Application to the UNRES force field Adam Liwo, Piotr Arłukowicz, Cezary Czaplewski, Stanisław Ołdziej, Jarosław Pillardy, and Harold A. Scheraga PMCID: PMC122298 Identification of a functional role for lipid asymmetry in biological membranes: Phosphatidylserine-skeletal protein interactions modulate membrane stability Sumie Manno, Yuichi Takakuwa, and Narla Mohandas PMCID: PMC122299 Intrinsic flexibility and gating mechanism of the potassium channel KcsA Yufeng Shen, Yifei Kong, and Jianpeng Ma PMCID: PMC122300 TROSY-NMR reveals interaction between ERp57 and the tip of the calreticulin P-domain Eva-Maria Frickel, Roland Riek, Ilian Jelesarov, Ari Helenius, Kurt Wüthrich, and Lars Ellgaard PMCID: PMC122301 From the Cover:
Mechanical disruption of individual nucleosomes reveals a reversible multistage release of DNA Brent D. Brower-Toland, Corey L. Smith, Richard C. Yeh, John T. Lis, Craig L. Peterson, and Michelle D. Wang PMCID: PMC122302 Cell Biology Alveolar epithelial type I cells contain transport proteins and transport sodium, supporting an active role for type I cells in regulation of lung liquid homeostasis Meshell D. Johnson, Jonathan H. Widdicombe, Lennell Allen, Pascal Barbry, and Leland G. Dobbs PMCID: PMC122303 Engineering gene expression and protein synthesis by modulation of nuclear shape Carson H. Thomas, Joel H. Collier, Charles S. Sfeir, and Kevin E. Healy PMCID: PMC122304 Centrosome amplification drives chromosomal instability in breast tumor development Wilma L. Lingle, Susan L. Barrett, Vivian C. Negron, Antonino B. D'Assoro, Kelly Boeneman, Wanguo Liu, Clark M. Whitehead, Carol Reynolds, and Jeffrey L. Salisbury PMCID: PMC122305 Functional studies on the role of the C-terminal domain of mammalian polo-like kinase Young-Joo Jang, Chin-Yo Lin, Sheng Ma, and Raymond L. Erikson PMCID: PMC122306 Arsenite-induced Cdc25C degradation is through the KEN-box and ubiquitin–proteasome pathway Fei Chen, Zhuo Zhang, Jacquelyn Bower, Yongju Lu, Stephen S. Leonard, Min Ding, Vince Castranova, Helen Piwnica-Worms, and Xianglin Shi PMCID: PMC122307 Targeting endothelium and its dynamic caveolae for tissue-specific transcytosis in vivo: A pathway to overcome cell barriers to drug and gene delivery Deirdre P. McIntosh, Xiang-Yang Tan, Phil Oh, and Jan E. Schnitzer PMCID: PMC122308 Mutagenesis of a functional chimeric gene in yeast identifies mutations in the simian virus 40 large T antigen J domain Sheara W. Fewell, James M. Pipas, and Jeffrey L. Brodsky PMCID: PMC122309 p56Lck anchors CD4 to distinct microdomains on microvilli Michelangelo Foti, Marie-Anne Phelouzat, Åsa Holm, Birgitta J. Rasmusson, and Jean-Louis Carpentier PMCID: PMC122310 Measuring tubulin content in Toxoplasma gondii: A comparison of laser-scanning confocal and wide-field fluorescence microscopy Jason R. Swedlow, Ke Hu, Paul D. Andrews, David S. Roos, and John M. Murray PMCID: PMC122311 Developmental Biology Conservation of Pax 6 function and upstream activation by Notch signaling in eye development of frogs and flies Yasuko Onuma, Shuji Takahashi, Makoto Asashima, Shoichiro Kurata, and Walter J. Gehring PMCID: PMC122312 Motility initiation in herring sperm is regulated by reverse sodium-calcium exchange Carol A. Vines, Kaoru Yoshida, Frederick J. Griffin, Murali C. Pillai, Masaaki Morisawa, Ryuzo Yanagimachi, and Gary N. Cherr PMCID: PMC122313 Pattern formation by a cell surface-associated morphogen in Myxococcus xanthus Lars Jelsbak and Lotte Søgaard-Andersen PMCID: PMC122314 Ecology Increased pollen flow counteracts fragmentation in a tropical dry forest: An example from Swietenia humilis Zuccarini G. M. White, D. H. Boshier, and W. Powell PMCID: PMC122315 Suppression of proliferation and cardiomyocyte hypertrophy by CHAMP, a cardiac-specific RNA helicase Zhi-Ping Liu and Eric N. Olson PMCID: PMC122316 Mutation, specialization, and hypersensitivity in highly optimized tolerance Tong Zhou, J. M. Carlson, and John Doyle PMCID: PMC122317 Evolution Large extinctions in an evolutionary model: The role of innovation and keystone species Sanjay Jain and Sandeep Krishna PMCID: PMC122318 Impact of the terminal Cretaceous event on plant–insect associations Conrad C. Labandeira, Kirk R. Johnson, and Peter Wilf PMCID: PMC122319 Hotspots and the conservation of evolutionary history Wes Sechrest, Thomas M. Brooks, Gustavo A. B. da Fonseca, William R. Konstant, Russell A. Mittermeier, Andy Purvis, Anthony B. Rylands, and John L. Gittleman PMCID: PMC122320 Specificity and robustness in transcription control networks Anirvan M. Sengupta, Marko Djordjevic, and Boris I. Shraiman PMCID: PMC122321 Topping off: A mechanism of first-male sperm precedence in a vertebrate Adam G. Jones, Erika M. Adams, and Stevan J. Arnold PMCID: PMC122322 Long-term microclimatic stress causes rapid adaptive radiation of kaiABC clock gene family in a cyanobacterium, Nostoc linckia, from “Evolution Canyons” I and II, Israel Volodymyr Dvornyk, Oxana Vinogradova, and Eviatar Nevo PMCID: PMC123721 HOX genes in the sepiolid squid Euprymna scolopes: Implications for the evolution of complex body plans Patrick Callaerts, Patricia N. Lee, Britta Hartmann, Claudia Farfan, Darrett W. Y. Choy, Kazuho Ikeo, Karl-Friedrich Fischbach, Walter J. Gehring, and H. Gert de Couet PMCID: PMC122323 Genetics Integration of foreign DNA during natural transformation of Acinetobacter sp. by homology-facilitated illegitimate recombination Johann de Vries and Wilfried Wackernagel PMCID: PMC122324 Homologous recombination at the border: Insertion-deletions and the trapping of foreign DNA in Streptococcus pneumoniae Marc Prudhomme, Virginie Libante, and Jean-Pierre Claverys PMCID: PMC122325 A comparative radiation hybrid map of bovine chromosome 18 and homologous chromosomes in human and mice Tom Goldammer, Srinivas R. Kata, Ronald M. Brunner, Ute Dorroch, Hanka Sanftleben, Manfred Schwerin, and James E. Womack PMCID: PMC122326 The archetype STYX/dead-phosphatase complexes with a spermatid mRNA-binding protein and is essential for normal sperm production Matthew J. Wishart and Jack E. Dixon PMCID: PMC122327 Analysis of DNA microarrays using algorithms that employ rule-based expert knowledge Kuang-Hung Pan, Chih-Jian Lih, and Stanley N. Cohen PMCID: PMC122328 Characterization of the Met326Ile variant of phosphatidylinositol 3-kinase p85α Katrine Almind, Laurent Delahaye, Torben Hansen, Emmanuel Van Obberghen, Oluf Pedersen, and C. Ronald Kahn PMCID: PMC122329 Discovery of five conserved β-defensin gene clusters using a computational search strategy Brian C. Schutte, Joseph P. Mitros, Jennifer A. Bartlett, Jesse D. Walters, Hong Peng Jia, Michael J. Welsh, Thomas L. Casavant, and Paul B. McCray, Jr. PMCID: PMC122330 Loss of circadian clock function decreases reproductive fitness in males of Drosophila melanogaster L. M. Beaver, B. O. Gvakharia, T. S. Vollintine, D. M. Hege, R. Stanewsky, and J. M. Giebultowicz PMCID: PMC122331 Transgenesis by lentiviral vectors: Lack of gene silencing in mammalian embryonic stem cells and preimplantation embryos Alexander Pfeifer, Masahito Ikawa, Yelena Dayn, and Inder M. Verma PMCID: PMC122332 T-DNA integration into the barley genome from single and double cassette vectors Rainer Stahl, Henriette Horvath, Jennifer Van Fleet, Michael Voetz, Diter von Wettstein, and Norbert Wolf PMCID: PMC122333 Constitutive expression of a single antimicrobial peptide can restore wild-type resistance to infection in immunodeficient Drosophila mutants Phoebe Tzou, Jean-Marc Reichhart, and Bruno Lemaitre PMCID: PMC122334 Caenorhabditis elegans DNA mismatch repair gene msh-2 is required for microsatellite stability and maintenance of genome integrity Natasha P. Degtyareva, Patricia Greenwell, E. Randal Hofmann, Michael O. Hengartner, Lijia Zhang, Joseph G. Culotti, and Thomas D. Petes PMCID: PMC122335 Amplification–mutagenesis: Evidence that “directed” adaptive mutation and general hypermutability result from growth with a selected gene amplification Heather Hendrickson, E. Susan Slechta, Ulfar Bergthorsson, Dan I. Andersson, and John R. Roth PMCID: PMC122336 Immunology Abnormal B lymphocyte development and autoimmunity in hypoxia-inducible factor 1α-deficient chimeric mice Hidefumi Kojima, Hua Gu, Saeko Nomura, Charles C. Caldwell, Tetsuji Kobata, Peter Carmeliet, Gregg L. Semenza, and Michail V. Sitkovsky PMCID: PMC122337 Pim serine/threonine kinases regulate the stability of Socs-1 protein X. Peter Chen, Julie A. Losman, Simone Cowan, Elizabeth Donahue, Scott Fay, Bao Q. Vuong, Martijn C. Nawijn, Danielle Capece, Victoria L. Cohan, and Paul Rothman PMCID: PMC122338 Interactions between double positive thymocytes and high affinity ligands presented by cortical epithelial cells generate double negative thymocytes with T cell regulatory activity Rongfang Wang, Yiran Wang-Zhu, and Howard Grey PMCID: PMC122339 Discrimination of MHC-derived odors by untrained mice is consistent with divergence in peptide-binding region residues Lara S. Carroll, Dustin J. Penn, and Wayne K. Potts PMCID: PMC122340 Medical Sciences Synergistic effects of L- and P-selectin in facilitating tumor metastasis can involve non-mucin ligands and implicate leukocytes as enhancers of metastasis Lubor Borsig, Richard Wong, Richard O. Hynes, Nissi M. Varki, and Ajit Varki PMCID: PMC122341 Marrow stromal cells form guiding strands in the injured spinal cord and promote recovery C. P. Hofstetter, E. J. Schwarz, D. Hess, J. Widenfalk, A. El Manira, Darwin J. Prockop, and L. Olson PMCID: PMC122342 The AF-1 activation-function of ERα may be dispensable to mediate the effect of estradiol on endothelial NO production in mice C. Pendaries, B. Darblade, P. Rochaix, A. Krust, P. Chambon, K. S. Korach, F. Bayard, and J.-F. Arnal PMCID: PMC122343 A peptide derived from α-fetoprotein prevents the growth of estrogen-dependent human breast cancers sensitive and resistant to tamoxifen James A. Bennett, Fassil B. Mesfin, Thomas T. Andersen, John F. Gierthy, and Herbert I. Jacobson PMCID: PMC122344 Overhauser enhanced magnetic resonance imaging for tumor oximetry: Coregistration of tumor anatomy and tissue oxygen concentration Murali C. Krishna, Sean English, Kenichi Yamada, John Yoo, Ramachandran Murugesan, Nallathamby Devasahayam, John A. Cook, Klaes Golman, Jan Henrik Ardenkjaer-Larsen, Sankaran Subramanian, and James B. Mitchell PMCID: PMC122345 Inhibitors of soluble epoxide hydrolase attenuate vascular smooth muscle cell proliferation Benjamin B. Davis, David A. Thompson, Laura L. Howard, Christophe Morisseau, Bruce D. Hammock, and Robert H. Weiss PMCID: PMC122346 The first linkage disequilibrium (LD) maps: Delineation of hot and cold blocks by diplotype analysis N. Maniatis, A. Collins, C.-F. Xu, L. C. McCarthy, D. R. Hewett, W. Tapper, S. Ennis, X. Ke, and N. E. Morton PMCID: PMC122347 Laser capture microdissection analysis of gene expression in macrophages from atherosclerotic lesions of apolipoprotein E-deficient mice Eugene Trogan, Robin P. Choudhury, Hayes M. Dansky, James X. Rong, Jan L. Breslow, and Edward A. Fisher PMCID: PMC122348 WASp verprolin homology, cofilin homology, and acidic region domain-mediated actin polymerization is required for T cell development Jinyi Zhang, Fabio Shi, Karen Badour, Yupu Deng, Mary K. H. McGavin, and Katherine A. Siminovitch PMCID: PMC122349 Heterogeneous proliferative potential of occult metastatic cells in bone marrow of patients with solid epithelial tumors Oender Solakoglu, Christine Maierhofer, Georgia Lahr, Elisabeth Breit, Peter Scheunemann, Isabella Heumos, Uwe Pichlmeier, Günter Schlimok, Ralph Oberneder, Manfred W. Köllermann, Jens Köllermann, Michael R. Speicher, and Klaus Pantel PMCID: PMC122350 Molecular specialization of breast vasculature: A breast-homing phage-displayed peptide binds to aminopeptidase P in breast vasculature Markus Essler and Erkki Ruoslahti PMCID: PMC122351 Erythropoietin prevents motor neuron apoptosis and neurologic disability in experimental spinal cord ischemic injury Murat Celik, Necati Gökmen, Serhat Erbayraktar, Mustafa Akhisaroglu, Selman Konakç, Cagnur Ulukus, Sermin Genc, Kursad Genc, Emel Sagiroglu, Anthony Cerami, and Michael Brines PMCID: PMC122352 Iron deficiency and iron excess damage mitochondria and mitochondrial DNA in rats Patrick B. Walter, Mitchell D. Knutson, Andres Paler-Martinez, Sonia Lee, Yu Xu, Fernando E. Viteri, and Bruce N. Ames PMCID: PMC122353 Motexafin gadolinium (Gd-Tex) selectively induces apoptosis in HIV-1 infected CD4+ T helper cells Omar D. Perez, Garry P. Nolan, Darren Magda, Richard A. Miller, Leonard A. Herzenberg, and Leonore A. Herzenberg PMCID: PMC122354 Microbiology Genomewide identification of Pseudomonas syringae pv. tomato DC3000 promoters controlled by the HrpL alternative sigma factor Derrick E. Fouts, Robert B. Abramovitch, James R. Alfano, Angela M. Baldo, C. Robin Buell, Samuel Cartinhour, Arun K. Chatterjee, Mark D'Ascenzo, Michelle L. Gwinn, Sondra G. Lazarowitz, Nai-Chun Lin, Gregory B. Martin, Amos H. Rehm, David J. Schneider, Karin van Dijk, Xiaoyan Tang, and Alan Collmer PMCID: PMC122355 Murine retroviruses activate B cells via interaction with toll-like receptor 4 John C. Rassa, Jennifer L. Meyers, Yuanming Zhang, Rama Kudaravalli, and Susan R. Ross PMCID: PMC122356 Surface sensing and adhesion of Escherichia coli controlled by the Cpx-signaling pathway Karen Otto and Thomas J. Silhavy PMCID: PMC122357 An iron-regulated sortase anchors a class of surface protein during Staphylococcus aureus pathogenesis Sarkis K. Mazmanian, Hung Ton-That, Kenneth Su, and Olaf Schneewind PMCID: PMC122358 Neurobiology The neural basis of intermittent motor control in humans J. Gross, L. Timmermann, J. Kujala, M. Dirks, F. Schmitz, R. Salmelin, and A. Schnitzler PMCID: PMC122359 Developing nodes of Ranvier are defined by ankyrin-G clustering and are independent of paranodal axoglial adhesion Scott M. Jenkins and Vann Bennett PMCID: PMC122360 Disruption of primary auditory cortex by synchronous auditory inputs during a critical period Li I. Zhang, Shaowen Bao, and Michael M. Merzenich PMCID: PMC122361 Lesions of the nucleus basalis magnocellularis induced by 192 IgG-saporin block memory enhancement with posttraining norepinephrine in the basolateral amygdala Ann E. Power, Leon J. Thal, and James L. McGaugh PMCID: PMC122362 Adeno-associated virus effectively mediates conditional gene modification in the brain Brian K. Kaspar, Bryce Vissel, Tasha Bengoechea, Steven Crone, Lynne Randolph-Moore, Rolf Muller, Eugene P. Brandon, David Schaffer, Inder M. Verma, Kuo-Fen Lee, Stephen F. Heinemann, and Fred H. Gage PMCID: PMC122363 Functional implications of the localization and activity of acid-sensitive channels in rat peripheral nervous system Diego Alvarez de la Rosa, Ping Zhang, Deren Shao, Fletcher White, and Cecilia M. Canessa PMCID: PMC122364 A liposome-based therapeutic vaccine against β-amyloid plaques on the pancreas of transgenic NORBA mice Claude Nicolau, Ruth Greferath, Teodor Silviu Balaban, Jaime E. Lazarte, and Robert J. Hopkins PMCID: PMC122365 Heteromultimers of DEG/ENaC subunits form H+-gated channels in mouse sensory neurons Christopher J. Benson, Jinghui Xie, John A. Wemmie, Margaret P. Price, Jillian M. Henss, Michael J. Welsh, and Peter M. Snyder PMCID: PMC122366 From the Cover:
Embryonic stem cells develop into functional dopaminergic neurons after transplantation in a Parkinson rat model Lars M. Björklund, Rosario Sánchez-Pernaute, Sangmi Chung, Therese Andersson, Iris Yin Ching Chen, Kevin St. P. McNaught, Anna-Liisa Brownell, Bruce G. Jenkins, Claes Wahlestedt, Kwang-Soo Kim, and Ole Isacson PMCID: PMC122367 Regulation of Kv1 subunit expression in oligodendrocyte progenitor cells and their role in G1/S phase progression of the cell cycle R. Chittajallu, Y. Chen, H. Wang, X. Yuan, C. A. Ghiani, T. Heckman, C. J. McBain, and V. Gallo PMCID: PMC122368 Memory loss in old rats is associated with brain mitochondrial decay and RNA/DNA oxidation: Partial reversal by feeding acetyl-l-carnitine and/or R-α-lipoic acid Jiankang Liu, Elizabeth Head, Afshin M. Gharib, Wenjun Yuan, Russell T. Ingersoll, Tory M. Hagen, Carl W. Cotman, and Bruce N. Ames PMCID: PMC122369 Ischemic preconditioning acts upstream of GluR2 down-regulation to afford neuroprotection in the hippocampal CA1 Hidenobu Tanaka, Agata Calderone, Teresa Jover, Sonja Y. Grooms, Hidenori Yokota, R. Suzanne Zukin, and Michael V. L. Bennett PMCID: PMC122370 The brain-derived neurotrophic factor enhances synthesis of Arc in synaptoneurosomes Yong Yin, Gerald M. Edelman, and Peter W. Vanderklish PMCID: PMC122371 Pharmacology Attenuation of thermal nociception and hyperalgesia by VR1 blockers Carolina García-Martínez, Marc Humet, Rosa Planells-Cases, Ana Gomis, Marco Caprini, Felix Viana, Elvira De la Peña, Francisco Sanchez-Baeza, Teresa Carbonell, Carmen De Felipe, Enrique Pérez-Payá, Carlos Belmonte, Angel Messeguer, and Antonio Ferrer-Montiel PMCID: PMC122372 Physiology Functional implications of the localization and activity of acid-sensitive channels in rat peripheral nervous system Diego Alvarez de la Rosa, Ping Zhang, Deren Shao, Fletcher White, and Cecilia M. Canessa PMCID: PMC122364 Ca2+ marks: Miniature calcium signals in single mitochondria driven by ryanodine receptors Pál Pacher, Andrew P. Thomas, and György Hajnóczky PMCID: PMC122373 Gonadotropin-releasing hormone neurons in the preoptic-hypothalamic region of the rat contain lamprey gonadotropin-releasing hormone III, mammalian luteinizing hormone-releasing hormone, or both peptides J. K. Hiney, S. A. Sower, W. H. Yu, S. M. McCann, and W. L. Dees PMCID: PMC122374 Expression of bitter taste receptors of the T2R family in the gastrointestinal tract and enteroendocrine STC-1 cells S. Vincent Wu, Nora Rozengurt, Moon Yang, Steven H. Young, James Sinnett-Smith, and Enrique Rozengurt PMCID: PMC122375 A dynamic model of the type-2 inositol trisphosphate receptor James Sneyd and Jean-François Dufour PMCID: PMC122376 Plant Biology Resistance to Ralstonia solanacearum in Arabidopsis thaliana is conferred by the recessive RRS1-R gene, a member of a novel family of resistance genes Laurent Deslandes, Jocelyne Olivier, Frédéric Theulières, Judith Hirsch, Dong Xin Feng, Peter Bittner-Eddy, Jim Beynon, and Yves Marco PMCID: PMC122377 Low-temperature-induced accumulation of xanthophylls and its structural consequences in the photosynthetic membranes of the cyanobacterium Cylindrospermopsis raciborskii: An FTIR spectroscopic study Zsuzsanna Várkonyi, Kazuomori Masamoto, Mónika Debreczeny, Ottó Zsiros, Bettina Ughy, Zoltán Gombos, Ildikó Domonkos, Tibor Farkas, Hajime Wada, and Balázs Szalontai PMCID: PMC122378 Analysis of MADS box protein–protein interactions in living plant cells Richard G. H. Immink, Theodorus W. J. Gadella, Jr., Silvia Ferrario, Marco Busscher, and Gerco C. Angenent PMCID: PMC122379 Intracellular distribution of viral gene products regulates a complex mechanism of cauliflower mosaic virus acquisition by its aphid vector Martin Drucker, Rémy Froissart, Eugénie Hébrard, Marilyne Uzest, Marc Ravallec, Pascal Espérandieu, Jean-Claude Mani, Martine Pugnière, Françoise Roquet, Alberto Fereres, and Stéphane Blanc PMCID: PMC122380 Crosstalk among stress responses in plants: Pathogen defense overrides UV protection through an inversely regulated ACE/ACE type of light-responsive gene promoter unit Elke Logemann and Klaus Hahlbrock PMCID: PMC122381 Blue light-induced kinetics of H+ and Ca2+ fluxes in etiolated wild-type and phototropin-mutant Arabidopsis seedlings Olga Babourina, Ian Newman, and Sergey Shabala PMCID: PMC122382 Sensitivity to Alternaria alternata toxin in citrus because of altered mitochondrial RNA processing Kouhei Ohtani, Hiroyuki Yamamoto, and Kazuya Akimitsu PMCID: PMC122383 From the Cover:
Nuts, nut cracking, and pitted stones at Gesher Benot Ya‘aqov, Israel Naama Goren-Inbar, Gonen Sharon, Yoel Melamed, and Mordechai Kislev PMCID: PMC122386 Population Biology Cryptic invasion by a non-native genotype of the common reed, Phragmites australis, into North America Kristin Saltonstall PMCID: PMC122384 Psychology Brain activity in ventromedial prefrontal cortex correlates with individual differences in negative affect David H. Zald, Dorothy L. Mattson, and José V. Pardo PMCID: PMC122385 Social Sciences Anthropology From the Cover:
Nuts, nut cracking, and pitted stones at Gesher Benot Ya‘aqov, Israel Naama Goren-Inbar, Gonen Sharon, Yoel Melamed, and Mordechai Kislev PMCID: PMC122386 Economic Sciences Large extinctions in an evolutionary model: The role of innovation and keystone species Sanjay Jain and Sandeep Krishna PMCID: PMC122318 Correction Proc Natl Acad Sci U S A. 2002 February 19; 99(4): 2461. Published online 2002 February 12. PMCID: PMC122262 Corrects: Keh-Chuang Chin, et al. INAUGURAL ARTICLE by a Recently Elected Academy Member: Viperin (cig5), an IFN-inducible antiviral protein directly
induced by human cytomegalovirus. Proc Natl Acad Sci U S A. 2001 December 18; 98(26): 15125–15130. |
