| | This journal provides immediate access to some articles. In This Issue Proc Natl Acad Sci U S A. 2005 February 1; 102(5): 1265–1266. doi: 10.1073/iti0505102.PMCID: PMC547895 Commentaries A new mechanism for immunologic initiation of asthma Allen P. Kaplan Proc Natl Acad Sci U S A. 2005 February 1; 102(5): 1267–1268. Published online 2005 January 26. doi: 10.1073/pnas.0409828102.PMCID: PMC547894 Perinatal imprinting by estrogen and adult prostate disease Olle Söder Proc Natl Acad Sci U S A. 2005 February 1; 102(5): 1269–1270. Published online 2005 January 26. doi: 10.1073/pnas.0409703102.PMCID: PMC547893 Bacterial subversion of the host secretory pathway Craig R. Roy Proc Natl Acad Sci U S A. 2005 February 1; 102(5): 1271–1272. Published online 2005 January 26. doi: 10.1073/pnas.0409531101.PMCID: PMC547872 Mistakes in translation don't translate into termination Randall A. Hughes and Andrew D. Ellington Proc Natl Acad Sci U S A. 2005 February 1; 102(5): 1273–1274. Published online 2005 January 26. doi: 10.1073/pnas.0409443101.PMCID: PMC547853 The ups and downs of gene expression and retroviral DNA integration Alan Engelman Proc Natl Acad Sci U S A. 2005 February 1; 102(5): 1275–1276. Published online 2005 January 26. doi: 10.1073/pnas.0409587101.PMCID: PMC547887 Physical Sciences Applied Mathematics An Eulerian path approach to local multiple alignment for DNA sequences Yu Zhang and Michael S. Waterman Proc Natl Acad Sci U S A. 2005 February 1; 102(5): 1285–1290. Published online 2005 January 24. doi: 10.1073/pnas.0409240102.PMCID: PMC547885 Chemistry INAUGURAL ARTICLE by a Recently Elected Academy Member: Biography of Louis E. Brus Tinsley Davis Proc Natl Acad Sci U S A. 2005 February 1; 102(5): 1277–1279. Published online 2005 January 26. doi: 10.1073/pnas.0409555102.PMCID: PMC547879 INAUGURAL ARTICLE by a Recently Elected Academy Member: Optical forces between metallic particles A. J. Hallock, P. L. Redmond, and L. E. Brus Proc Natl Acad Sci U S A. 2005 February 1; 102(5): 1280–1284. Published online 2005 January 12. doi: 10.1073/pnas.0408604101.PMCID: PMC547848 Regular multicharged transient soft matter in Coulomb explosion of heteroclusters Isidore Last and Joshua Jortner Proc Natl Acad Sci U S A. 2005 February 1; 102(5): 1291–1295. Published online 2005 January 21. doi: 10.1073/pnas.0408636102.PMCID: PMC547852 Bacterial glycolipids and analogs as antigens for CD1d-restricted NKT cells Douglass Wu, Guo-Wen Xing, Michael A. Poles, Amir Horowitz, Yuki Kinjo, Barbara Sullivan, Vera Bodmer-Narkevitch, Oliver Plettenburg, Mitchell Kronenberg, Moriya Tsuji, David D. Ho, and Chi-Huey Wong Proc Natl Acad Sci U S A. 2005 February 1; 102(5): 1351–1356. Published online 2005 January 21. doi: 10.1073/pnas.0408696102.PMCID: PMC547854 Engineering Microengineered hydromechanical cochlear model Robert D. White and Karl Grosh Proc Natl Acad Sci U S A. 2005 February 1; 102(5): 1296–1301. Published online 2005 January 21. doi: 10.1073/pnas.0407446102.PMCID: PMC547842 Geology Feedbacks and the coevolution of plants and atmospheric CO2 David J. Beerling and Robert A. Berner Proc Natl Acad Sci U S A. 2005 February 1; 102(5): 1302–1305. Published online 2005 January 24. doi: 10.1073/pnas.0408724102.PMCID: PMC547859 Geophysics Short-lived chlorine-36 in a Ca- and Al-rich inclusion from the Ningqiang carbonaceous chondrite Yangting Lin, Yunbin Guan, Laurie A. Leshin, Ziyuan Ouyang, and Daode Wang Proc Natl Acad Sci U S A. 2005 February 1; 102(5): 1306–1311. Published online 2005 January 25. doi: 10.1073/pnas.0407173101.PMCID: PMC547833 Biological Sciences Anthropology Gene flow across linguistic boundaries in Native North American populations Keith Hunley and Jeffrey C. Long Proc Natl Acad Sci U S A. 2005 February 1; 102(5): 1312–1317. Published online 2005 January 24. doi: 10.1073/pnas.0409301102.PMCID: PMC547813 Applied Biological Sciences Genes for direct methylation of glycine provide high levels of glycinebetaine and abiotic-stress tolerance in Synechococcus and Arabidopsis Rungaroon Waditee, Md. Nazmul H. Bhuiyan, Vandna Rai, Kenji Aoki, Yoshito Tanaka, Takashi Hibino, Shigetoshi Suzuki, Jun Takano, André T. Jagendorf, Tetsuko Takabe, and Teruhiro Takabe Proc Natl Acad Sci U S A. 2005 February 1; 102(5): 1318–1323. Published online 2005 January 21. doi: 10.1073/pnas.0409017102.PMCID: PMC547866 Iron release from macrophages after erythrophagocytosis is up-regulated by ferroportin 1 overexpression and down-regulated by hepcidin Mitchell D. Knutson, Mohamed Oukka, Lindsey M. Koss, Fikret Aydemir, and Marianne Wessling-Resnick Proc Natl Acad Sci U S A. 2005 February 1; 102(5): 1324–1328. Published online 2005 January 21. doi: 10.1073/pnas.0409409102.PMCID: PMC547844 Biochemistry Chromatin remodeling by DNA bending, not twisting Yahli Lorch, Barbara Davis, and Roger D. Kornberg Proc Natl Acad Sci U S A. 2005 February 1; 102(5): 1329–1332. Published online 2005 January 26. doi: 10.1073/pnas.0409413102.PMCID: PMC546017 ATP-driven stepwise rotation of FoF1-ATP synthase Hiroshi Ueno, Toshiharu Suzuki, Kazuhiko Kinosita, Jr., and Masasuke Yoshida Proc Natl Acad Sci U S A. 2005 February 1; 102(5): 1333–1338. Published online 2005 January 24. doi: 10.1073/pnas.0407857102.PMCID: PMC545493 Identification of target genes in breast cancer cells directly regulated by the SRC-3/AIB1 coactivator Paul Labhart, Sudipan Karmakar, Eleni M. Salicru, Brian S. Egan, Vassilios Alexiadis, Bert W. O'Malley, and Carolyn L. Smith Proc Natl Acad Sci U S A. 2005 February 1; 102(5): 1339–1344. Published online 2005 January 26. doi: 10.1073/pnas.0409578102.PMCID: PMC547886 Inhibition of homologous recombination by variants of the catalytic subunit of the DNA-dependent protein kinase (DNA-PKcs) Erin Convery, Euy Kyun Shin, Qi Ding, Wei Wang, Pauline Douglas, Laurie S. Davis, Jac A. Nickoloff, Susan P. Lees-Miller, and Katheryn Meek Proc Natl Acad Sci U S A. 2005 February 1; 102(5): 1345–1350. Published online 2005 January 24. doi: 10.1073/pnas.0406466102.PMCID: PMC547837 Bacterial glycolipids and analogs as antigens for CD1d-restricted NKT cells Douglass Wu, Guo-Wen Xing, Michael A. Poles, Amir Horowitz, Yuki Kinjo, Barbara Sullivan, Vera Bodmer-Narkevitch, Oliver Plettenburg, Mitchell Kronenberg, Moriya Tsuji, David D. Ho, and Chi-Huey Wong Proc Natl Acad Sci U S A. 2005 February 1; 102(5): 1351–1356. Published online 2005 January 21. doi: 10.1073/pnas.0408696102.PMCID: PMC547854 Inositol 1,4,5-trisphosphate receptor/GAPDH complex augments Ca2+ release via locally derived NADH Randen L. Patterson, Damian B. van Rossum, Adam I. Kaplin, Roxanne K. Barrow, and Solomon H. Snyder Proc Natl Acad Sci U S A. 2005 February 1; 102(5): 1357–1359. Published online 2005 January 26. doi: 10.1073/pnas.0409657102.PMCID: PMC547892 Ancestry and progeny of nutrient amino acid transporters Dmitri Y. Boudko, Andrea B. Kohn, Ella A. Meleshkevitch, Michelle K. Dasher, Theresa J. Seron, Bruce R. Stevens, and William R. Harvey Proc Natl Acad Sci U S A. 2005 February 1; 102(5): 1360–1365. Published online 2005 January 21. doi: 10.1073/pnas.0405183101.PMCID: PMC547818 Structural basis of nonnatural amino acid recognition by an engineered aminoacyl-tRNA synthetase for genetic code expansion Takatsugu Kobayashi, Kensaku Sakamoto, Tetsuo Takimura, Ryo Sekine, Kelly Vincent, Kenji Kamata, Susumu Nishimura, and Shigeyuki Yokoyama Proc Natl Acad Sci U S A. 2005 February 1; 102(5): 1366–1371. Published online 2005 January 25. doi: 10.1073/pnas.0407039102.PMCID: PMC547826 An intermolecular base triple as the basis of ligand specificity and affinity in the guanine- and adenine-sensing riboswitch RNAs Jonas Noeske, Christian Richter, Marc A. Grundl, Hamid R. Nasiri, Harald Schwalbe, and Jens Wöhnert Proc Natl Acad Sci U S A. 2005 February 1; 102(5): 1372–1377. Published online 2005 January 21. doi: 10.1073/pnas.0406347102.PMCID: PMC547832 Crystal structure of a pH-regulated luciferase catalyzing the bioluminescent oxidation of an open tetrapyrrole L. Wayne Schultz, Liyun Liu, Margaret Cegielski, and J. Woodland Hastings Proc Natl Acad Sci U S A. 2005 February 1; 102(5): 1378–1383. Published online 2005 January 21. doi: 10.1073/pnas.0409335102.PMCID: PMC547824 Glucose and fat metabolism in adipose tissue of acetyl-CoA carboxylase 2 knockout mice WonKeun Oh, Lutfi Abu-Elheiga, Parichher Kordari, Zeiwei Gu, Tattym Shaikenov, Subrahmanyam S. Chirala, and Salih J. Wakil Proc Natl Acad Sci U S A. 2005 February 1; 102(5): 1384–1389. Published online 2005 January 26. doi: 10.1073/pnas.0409451102.PMCID: PMC547858 Partitioning between unfolding and release of native domains during ClpXP degradation determines substrate selectivity and partial processing Jon A. Kenniston, Tania A. Baker, and Robert T. Sauer Proc Natl Acad Sci U S A. 2005 February 1; 102(5): 1390–1395. Published online 2005 January 25. doi: 10.1073/pnas.0409634102.PMCID: PMC547888 Biophysics A segment of cold shock protein directs the folding of a combinatorial protein Stephanie de Bono, Lutz Riechmann, Eric Girard, Roger L. Williams, and Greg Winter Proc Natl Acad Sci U S A. 2005 February 1; 102(5): 1396–1401. Published online 2005 January 25. doi: 10.1073/pnas.0407298102.PMCID: PMC547839 Statistical analysis of MPSS measurements: Application to the study of LPS-activated macrophage gene expression G. A. Stolovitzky, A. Kundaje, G. A. Held, K. H. Duggar, C. D. Haudenschild, D. Zhou, T. J. Vasicek, K. D. Smith, A. Aderem, and J. C. Roach Proc Natl Acad Sci U S A. 2005 February 1; 102(5): 1402–1407. Published online 2005 January 24. doi: 10.1073/pnas.0406555102.PMCID: PMC547838 Gating of acetylcholine receptor channels: Brownian motion across a broad transition state Anthony Auerbach Proc Natl Acad Sci U S A. 2005 February 1; 102(5): 1408–1412. Published online 2005 January 21. doi: 10.1073/pnas.0406787102.PMCID: PMC547815 Enthalpy of helix–coil transition: Missing link in rationalizing the thermodynamics of helix-forming propensities of the amino acid residues John M. Richardson, Maria M. Lopez, and George I. Makhatadze Proc Natl Acad Sci U S A. 2005 February 1; 102(5): 1413–1418. Published online 2005 January 25. doi: 10.1073/pnas.0408004102.PMCID: PMC547846 Single molecule high-resolution colocalization of Cy3 and Cy5 attached to macromolecules measures intramolecular distances through time L. Stirling Churchman, Zeynep Ökten, Ronald S. Rock, John F. Dawson, and James A. Spudich Proc Natl Acad Sci U S A. 2005 February 1; 102(5): 1419–1423. Published online 2005 January 24. doi: 10.1073/pnas.0409487102.PMCID: PMC545495 A push-pull mechanism for regulating integrin function Wei Li, Douglas G. Metcalf, Roman Gorelik, Renhao Li, Neal Mitra, Vikas Nanda, Peter B. Law, James D. Lear, William F. DeGrado, and Joel S. Bennett Proc Natl Acad Sci U S A. 2005 February 1; 102(5): 1424–1429. Published online 2005 January 25. doi: 10.1073/pnas.0409334102.PMCID: PMC547819 From the Cover: Release of long-range tertiary interactions potentiates aggregation of natively unstructured α-synuclein Carlos W. Bertoncini, Young-Sang Jung, Claudio O. Fernandez, Wolfgang Hoyer, Christian Griesinger, Thomas M. Jovin, and Markus Zweckstetter Proc Natl Acad Sci U S A. 2005 February 1; 102(5): 1430–1435. Published online 2005 January 25. doi: 10.1073/pnas.0407146102.PMCID: PMC547830 Cell Biology From the Cover: Relationship between retroviral DNA-integration-site selection and host cell transcription Lori F. Maxfield, Camilla D. Fraize, and John M. Coffin Proc Natl Acad Sci U S A. 2005 February 1; 102(5): 1436–1441. Published online 2005 January 19. doi: 10.1073/pnas.0409204102.PMCID: PMC547878 Functional antagonism of different G protein-coupled receptor kinases for β-arrestin-mediated angiotensin II receptor signaling Jihee Kim, Seungkirl Ahn, Xiu-Rong Ren, Erin J. Whalen, Eric Reiter, Huijun Wei, and Robert J. Lefkowitz Proc Natl Acad Sci U S A. 2005 February 1; 102(5): 1442–1447. Published online 2005 January 25. doi: 10.1073/pnas.0409532102.PMCID: PMC547874 Different G protein-coupled receptor kinases govern G protein and β-arrestin-mediated signaling of V2 vasopressin receptor Xiu-Rong Ren, Eric Reiter, Seungkirl Ahn, Jihee Kim, Wei Chen, and Robert J. Lefkowitz Proc Natl Acad Sci U S A. 2005 February 1; 102(5): 1448–1453. Published online 2005 January 25. doi: 10.1073/pnas.0409534102.PMCID: PMC547876 Impaired intranuclear trafficking of Runx2 (AML3/CBFA1) transcription factors in breast cancer cells inhibits osteolysis in vivo Amjad Javed, George L. Barnes, Jitesh Pratap, Tomasz Antkowiak, Louis C. Gerstenfeld, Andre J. van Wijnen, Janet L. Stein, Jane B. Lian, and Gary S. Stein Proc Natl Acad Sci U S A. 2005 February 1; 102(5): 1454–1459. Published online 2005 January 21. doi: 10.1073/pnas.0409121102.PMCID: PMC547873 The Wnt/β-catenin signaling pathway targets PPARγ activity in colon cancer cells Emmelie Å. Jansson, Alexandra Are, Gediminas Greicius, I-Chun Kuo, Denise Kelly, Velmurugesan Arulampalam, and Sven Pettersson Proc Natl Acad Sci U S A. 2005 February 1; 102(5): 1460–1465. Published online 2005 January 21. doi: 10.1073/pnas.0405928102.PMCID: PMC547827 A peptide inhibitor of cytochrome c/inositol 1,4,5-trisphosphate receptor binding blocks intrinsic and extrinsic cell death pathways Darren Boehning, Damian B. van Rossum, Randen L. Patterson, and Solomon H. Snyder Proc Natl Acad Sci U S A. 2005 February 1; 102(5): 1466–1471. Published online 2005 January 21. doi: 10.1073/pnas.0409650102.PMCID: PMC547891 Blebbistatin and blebbistatin-inactivated myosin II inhibit myosin II-independent processes in Dictyostelium Shi Shu, Xiong Liu, and Edward D. Korn Proc Natl Acad Sci U S A. 2005 February 1; 102(5): 1472–1477. Published online 2005 January 25. doi: 10.1073/pnas.0409528102.PMCID: PMC547870 The trans-Golgi network-associated human ubiquitin-protein ligase POSH is essential for HIV type 1 production Iris Alroy, Shmuel Tuvia, Tsvika Greener, Daphna Gordon, Haim M. Barr, Daniel Taglicht, Revital Mandil-Levin, Danny Ben-Avraham, Dalit Konforty, Anat Nir, Orit Levius, Vivian Bicoviski, Mally Dori, Shenhav Cohen, Liora Yaar, Omri Erez, Oshrat Propheta-Meiran, Mordechai Koskas, Elanite Caspi-Bachar, Iris Alchanati, Alin Sela-Brown, Haim Moskowitz, Uwe Tessmer, Ulrich Schubert, and Yuval Reiss Proc Natl Acad Sci U S A. 2005 February 1; 102(5): 1478–1483. Published online 2005 January 19. doi: 10.1073/pnas.0408717102.PMCID: PMC545085 Developmental Biology Estrogen receptor α and imprinting of the neonatal mouse ventral prostate by estrogen Yoko Omoto, Otabek Imamov, Margaret Warner, and Jan-Åke Gustafsson Proc Natl Acad Sci U S A. 2005 February 1; 102(5): 1484–1489. Published online 2005 January 21. doi: 10.1073/pnas.0409168102.PMCID: PMC547875 Lack of TCF2/vHNF1 in mice leads to pancreas agenesis C. Haumaitre, E. Barbacci, M. Jenny, M. O. Ott, G. Gradwohl, and S. Cereghini Proc Natl Acad Sci U S A. 2005 February 1; 102(5): 1490–1495. Published online 2005 January 24. doi: 10.1073/pnas.0405776102.PMCID: PMC547822 Supernumerary neuromasts in the posterior lateral line of zebrafish lacking peripheral glia Hernán López-Schier and A. J. Hudspeth Proc Natl Acad Sci U S A. 2005 February 1; 102(5): 1496–1501. Published online 2005 January 26. doi: 10.1073/pnas.0409361102.PMCID: PMC547829 Laminin α1 globular domains 4–5 induce fetal development but are not vital for embryonic basement membrane assembly Susanne Schéele, Mats Falk, Ahnders Franzén, Fredrik Ellin, Maria Ferletta, Peter Lonai, Björn Andersson, Rupert Timpl, Erik Forsberg, and Peter Ekblom Proc Natl Acad Sci U S A. 2005 February 1; 102(5): 1502–1506. Published online 2005 January 24. doi: 10.1073/pnas.0405095102.PMCID: PMC545491 Heparan 2-O-sulfotransferase, hst-2, is essential for normal cell migration in Caenorhabditis elegans Tarja Kinnunen, Zebo Huang, Joanne Townsend, Michelle M. Gatdula, Jillian R. Brown, Jeffrey D. Esko, and Jeremy E. Turnbull Proc Natl Acad Sci U S A. 2005 February 1; 102(5): 1507–1512. Published online 2005 January 25. doi: 10.1073/pnas.0401591102.PMCID: PMC547812 The DNA/RNA-binding protein MSY2 marks specific transcripts for cytoplasmic storage in mouse male germ cells Juxiang Yang, Sergey Medvedev, P. Prabhakara Reddi, Richard M. Schultz, and Norman B. Hecht Proc Natl Acad Sci U S A. 2005 February 1; 102(5): 1513–1518. Published online 2005 January 21. doi: 10.1073/pnas.0404685102.PMCID: PMC547816 Ecology Soil animals alter plant litter diversity effects on decomposition Stephan Hättenschwiler and Patrick Gasser Proc Natl Acad Sci U S A. 2005 February 1; 102(5): 1519–1524. Published online 2005 January 25. doi: 10.1073/pnas.0404977102.PMCID: PMC547817 Stable isotopes (δ13C and δ15N) of organic matrix from coral skeleton Leonard Muscatine, Claire Goiran, Lynton Land, Jean Jaubert, Jean-Pierre Cuif, and Denis Allemand Proc Natl Acad Sci U S A. 2005 February 1; 102(5): 1525–1530. Published online 2005 January 25. doi: 10.1073/pnas.0408921102.PMCID: PMC547863 Host population persistence in the face of introduced vector-borne diseases: Hawaii amakihi and avian malaria Bethany L. Woodworth, Carter T. Atkinson, Dennis A. LaPointe, Patrick J. Hart, Caleb S. Spiegel, Erik J. Tweed, Carlene Henneman, Jaymi LeBrun, Tami Denette, Rachel DeMots, Kelly L. Kozar, Dennis Triglia, Dan Lease, Aaron Gregor, Tom Smith, and David Duffy Proc Natl Acad Sci U S A. 2005 February 1; 102(5): 1531–1536. Published online 2005 January 24. doi: 10.1073/pnas.0409454102.PMCID: PMC547860 Evolution The position of Hippopotamidae within Cetartiodactyla Jean-Renaud Boisserie, Fabrice Lihoreau, and Michel Brunet Proc Natl Acad Sci U S A. 2005 February 1; 102(5): 1537–1541. Published online 2005 January 26. doi: 10.1073/pnas.0409518102.PMCID: PMC547867 A genomic population genetics analysis of the pathogenic enterocyte effacement island in Escherichia coli: The search for the unit of selection Amanda Castillo, Luis E. Eguiarte, and Valeria Souza Proc Natl Acad Sci U S A. 2005 February 1; 102(5): 1542–1547. Published online 2005 January 24. doi: 10.1073/pnas.0408633102.PMCID: PMC547851 The diversity of dolichol-linked precursors to Asn-linked glycans likely results from secondary loss of sets of glycosyltransferases John Samuelson, Sulagna Banerjee, Paula Magnelli, Jike Cui, Daniel J. Kelleher, Reid Gilmore, and Phillips W. Robbins Proc Natl Acad Sci U S A. 2005 February 1; 102(5): 1548–1553. Published online 2005 January 21. doi: 10.1073/pnas.0409460102.PMCID: PMC545090 From the Cover: Reconstructing early sponge relationships by using the Burgess Shale fossil Eiffelia globosa, Walcott Joseph P. Botting and Nicholas J. Butterfield Proc Natl Acad Sci U S A. 2005 February 1; 102(5): 1554–1559. Published online 2005 January 21. doi: 10.1073/pnas.0405867102.PMCID: PMC547825 Genetics Identifying tissue-selective transcription factor binding sites in vertebrate promoters Andrew D. Smith, Pavel Sumazin, and Michael Q. Zhang Proc Natl Acad Sci U S A. 2005 February 1; 102(5): 1560–1565. Published online 2005 January 24. doi: 10.1073/pnas.0406123102.PMCID: PMC547828 A computational and experimental approach to validating annotations and gene predictions in the Drosophila melanogaster genome Mark Yandell, Adina M. Bailey, Sima Misra, ShengQiang Shu, Colin Wiel, Martha Evans-Holm, Susan E. Celniker, and Gerald M. Rubin Proc Natl Acad Sci U S A. 2005 February 1; 102(5): 1566–1571. Published online 2005 January 24. doi: 10.1073/pnas.0409421102.PMCID: PMC545494 The landscape of genetic complexity across 5,700 gene expression traits in yeast Rachel B. Brem and Leonid Kruglyak Proc Natl Acad Sci U S A. 2005 February 1; 102(5): 1572–1577. Published online 2005 January 19. doi: 10.1073/pnas.0408709102.PMCID: PMC547855 Immunology From the Cover: Elicitation of allergic asthma by immunoglobulin free light chains Aletta D. Kraneveld, Mirjam Kool, Anneke H. van Houwelingen, Paul Roholl, Alan Solomon, Dirkje S. Postma, Frans P. Nijkamp, and Frank A. Redegeld Proc Natl Acad Sci U S A. 2005 February 1; 102(5): 1578–1583. Published online 2005 January 14. doi: 10.1073/pnas.0406808102.PMCID: PMC547820 Nibrin functions in Ig class-switch recombination Sven Kracker, Yvonne Bergmann, Ilja Demuth, Pierre-Olivier Frappart, Gabriele Hildebrand, Rainer Christine, Zhao-Qi Wang, Karl Sperling, Martin Digweed, and Andreas Radbruch Proc Natl Acad Sci U S A. 2005 February 1; 102(5): 1584–1589. Published online 2005 January 24. doi: 10.1073/pnas.0409191102.PMCID: PMC547877 Genomic instability, endoreduplication, and diminished Ig class-switch recombination in B cells lacking Nbs1 Bernardo Reina-San-Martin, Michel C. Nussenzweig, André Nussenzweig, and Simone Difilippantonio Proc Natl Acad Sci U S A. 2005 February 1; 102(5): 1590–1595. Published online 2005 January 24. doi: 10.1073/pnas.0406289102.PMCID: PMC547831 T-bet deficiency reduces atherosclerosis and alters plaque antigen-specific immune responses Chiara Buono, Christoph J. Binder, George Stavrakis, Joseph L. Witztum, Laurie H. Glimcher, and Andrew H. Lichtman Proc Natl Acad Sci U S A. 2005 February 1; 102(5): 1596–1601. Published online 2005 January 21. doi: 10.1073/pnas.0409015102.PMCID: PMC547865 A PKR-like eukaryotic initiation factor 2α kinase from zebrafish contains Z-DNA binding domains instead of dsRNA binding domains Stefan Rothenburg, Nikolaus Deigendesch, Katharina Dittmar, Friedrich Koch-Nolte, Friedrich Haag, Ky Lowenhaupt, and Alexander Rich Proc Natl Acad Sci U S A. 2005 February 1; 102(5): 1602–1607. Published online 2005 January 19. doi: 10.1073/pnas.0408714102.PMCID: PMC547857 Receptor editing in peripheral B cell tolerance Jeffrey S. Rice, Jeffrey Newman, Chuansheng Wang, Daniel J. Michael, and Betty Diamond Proc Natl Acad Sci U S A. 2005 February 1; 102(5): 1608–1613. Published online 2005 January 19. doi: 10.1073/pnas.0409217102.PMCID: PMC547880 Exposure of acidic residues as a danger signal for recognition of fibrinogen and other macromolecules by integrin αXβ2 Thomas Vorup-Jensen, Christopher V. Carman, Motomu Shimaoka, Peter Schuck, Juraj Svitel, and Timothy A. Springer Proc Natl Acad Sci U S A. 2005 February 1; 102(5): 1614–1619. Published online 2005 January 21. doi: 10.1073/pnas.0409057102.PMCID: PMC547869 Peptide 15-mers of defined sequence that substitute for random amino acid copolymers in amelioration of experimental autoimmune encephalomyelitis Joel N. H. Stern, Zsolt Illés, Jayagopala Reddy, Derin B. Keskin, Masha Fridkis-Hareli, Vijay K. Kuchroo, and Jack L. Strominger Proc Natl Acad Sci U S A. 2005 February 1; 102(5): 1620–1625. Published online 2005 January 21. doi: 10.1073/pnas.0409022102.PMCID: PMC547868 Unparalleled complexity of the MHC class I region in rhesus macaques Nel Otting, Corrine M. C. Heijmans, Riet C. Noort, Natasja G. de Groot, Gaby G. M. Doxiadis, Jon J. van Rood, David I. Watkins, and Ronald E. Bontrop Proc Natl Acad Sci U S A. 2005 February 1; 102(5): 1626–1631. Published online 2005 January 21. doi: 10.1073/pnas.0409084102.PMCID: PMC545086 Differential proton sensitivity of related G protein-coupled receptors T cell death-associated gene 8 and G2A expressed in immune cells Caius G. Radu, Amar Nijagal, Jami McLaughlin, Li Wang, and Owen N. Witte Proc Natl Acad Sci U S A. 2005 February 1; 102(5): 1632–1637. Published online 2005 January 21. doi: 10.1073/pnas.0409415102.PMCID: PMC545089 Medical Sciences Requirement of phospholipase D1 activity in H-RasV12-induced transformation F. Gregory Buchanan, Matt McReynolds, Anthony Couvillon, Yoonseok Kam, Vijaykumar R. Holla, Raymond N. DuBois, and John H. Exton Proc Natl Acad Sci U S A. 2005 February 1; 102(5): 1638–1642. Published online 2005 January 24. doi: 10.1073/pnas.0406698102.PMCID: PMC547811 Accessing key steps of human tumor progression in vivo by using an avian embryo model Martin Hagedorn, Sophie Javerzat, Delphine Gilges, Aurélie Meyre, Benjamin de Lafarge, Anne Eichmann, and Andreas Bikfalvi Proc Natl Acad Sci U S A. 2005 February 1; 102(5): 1643–1648. Published online 2005 January 21. doi: 10.1073/pnas.0408622102.PMCID: PMC547849 Skp2 inhibits FOXO1 in tumor suppression through ubiquitin-mediated degradation Haojie Huang, Kevin M. Regan, Fang Wang, Diping Wang, David I Smith, Jan M. A. van Deursen, and Donald J. Tindall Proc Natl Acad Sci U S A. 2005 February 1; 102(5): 1649–1654. Published online 2005 January 24. doi: 10.1073/pnas.0406789102.PMCID: PMC545492 Attenuation of cardiac remodeling after myocardial infarction by muscle LIM protein-calcineurin signaling at the sarcomeric Z-disc Joerg Heineke, Hartmut Ruetten, Christian Willenbockel, Sandra C. Gross, Marian Naguib, Arnd Schaefer, Tibor Kempf, Denise Hilfiker-Kleiner, Pico Caroni, Theresia Kraft, Robert A. Kaiser, Jeffery D. Molkentin, Helmut Drexler, and Kai C. Wollert Proc Natl Acad Sci U S A. 2005 February 1; 102(5): 1655–1660. Published online 2005 January 21. doi: 10.1073/pnas.0405488102.PMCID: PMC547821 Phosphodiesterase-5A dysregulation in penile erectile tissue is a mechanism of priapism Hunter C. Champion, Trinity J. Bivalacqua, Eiki Takimoto, David A. Kass, and Arthur L. Burnett Proc Natl Acad Sci U S A. 2005 February 1; 102(5): 1661–1666. Published online 2005 January 24. doi: 10.1073/pnas.0407183102.PMCID: PMC547836 BDNF modulates GABAA receptors microtransplanted from the human epileptic brain to Xenopus oocytes E. Palma, G. Torchia, C. Limatola, F. Trettel, A. Arcella, G. Cantore, G. Di Gennaro, M. Manfredi, V. Esposito, P. P. Quarato, R. Miledi, and F. Eusebi Proc Natl Acad Sci U S A. 2005 February 1; 102(5): 1667–1672. Published online 2005 January 21. doi: 10.1073/pnas.0409442102.PMCID: PMC547850 Microbiology From the Cover: Brucella coopts the small GTPase Sar1 for intracellular replication Jean Celli, Suzana P. Salcedo, and Jean-Pierre Gorvel Proc Natl Acad Sci U S A. 2005 February 1; 102(5): 1673–1678. Published online 2005 January 4. doi: 10.1073/pnas.0406873102.PMCID: PMC547823 Extracellular deoxyribonuclease made by group A Streptococcus assists pathogenesis by enhancing evasion of the innate immune response Paul Sumby, Kent D. Barbian, Donald J. Gardner, Adeline R. Whitney, Diane M. Welty, R. Daniel Long, John R. Bailey, Michael J. Parnell, Nancy P. Hoe, Gerald G. Adams, Frank R. DeLeo, and James M. Musser Proc Natl Acad Sci U S A. 2005 February 1; 102(5): 1679–1684. Published online 2005 January 24. doi: 10.1073/pnas.0406641102.PMCID: PMC547841 Predicted hexameric structure of the Agrobacterium VirB4 C terminus suggests VirB4 acts as a docking site during type IV secretion Rebecca Middleton, Kimmen Sjölander, Nandini Krishnamurthy, Jonathan Foley, and Patricia Zambryski Proc Natl Acad Sci U S A. 2005 February 1; 102(5): 1685–1690. Published online 2005 January 24. doi: 10.1073/pnas.0409399102.PMCID: PMC547840 Transient interference with staphylococcal quorum sensing blocks abscess formation Jesse S. Wright, III, Rhuzong Jin, and Richard P. Novick Proc Natl Acad Sci U S A. 2005 February 1; 102(5): 1691–1696. Published online 2005 January 21. doi: 10.1073/pnas.0407661102.PMCID: PMC547845 Inhibited cell growth and protein functional changes from an editing-defective tRNA synthetase Jamie M. Bacher, Valérie de Crécy-Lagard, and Paul R. Schimmel Proc Natl Acad Sci U S A. 2005 February 1; 102(5): 1697–1701. Published online 2005 January 12. doi: 10.1073/pnas.0409064102.PMCID: PMC547871 Seasonal epidemics of cholera inversely correlate with the prevalence of environmental cholera phages Shah M. Faruque, Iftekhar Bin Naser, M. Johirul Islam, A. S. G. Faruque, A. N. Ghosh, G. Balakrish Nair, David A. Sack, and John J. Mekalanos Proc Natl Acad Sci U S A. 2005 February 1; 102(5): 1702–1707. Published online 2005 January 14. doi: 10.1073/pnas.0408992102.PMCID: PMC547864 Neuroscience Structure of the kainate receptor subunit GluR6 agonist-binding domain complexed with domoic acid Max H. Nanao, Tim Green, Yael Stern-Bach, Stephen F. Heinemann, and Senyon Choe Proc Natl Acad Sci U S A. 2005 February 1; 102(5): 1708–1713. Published online 2005 January 26. doi: 10.1073/pnas.0409573102.PMCID: PMC547884 Role of SDF1 chemokine in the development of lateral line efferent and facial motor neurons Dora Sapède, Mireille Rossel, Christine Dambly-Chaudière, and Alain Ghysen Proc Natl Acad Sci U S A. 2005 February 1; 102(5): 1714–1718. Published online 2005 January 19. doi: 10.1073/pnas.0406382102.PMCID: PMC547835 Differential contribution of the three Aph1 genes to γ-secretase activity in vivo Lutgarde Serneels, Tim Dejaegere, Katleen Craessaerts, Katrien Horré, Ellen Jorissen, Thomas Tousseyn, Sébastien Hébert, Marcel Coolen, Gerard Martens, An Zwijsen, Wim Annaert, Dieter Hartmann, and Bart De Strooper Proc Natl Acad Sci U S A. 2005 February 1; 102(5): 1719–1724. Published online 2005 January 21. doi: 10.1073/pnas.0408901102.PMCID: PMC547495 Mu-opioid receptors modulate the stability of dendritic spines Dezhi Liao, Hang Lin, Ping Yee Law, and Horace H. Loh Proc Natl Acad Sci U S A. 2005 February 1; 102(5): 1725–1730. Published online 2005 January 19. doi: 10.1073/pnas.0406797102.PMCID: PMC545084 The Abl/Arg substrate ArgBP2/nArgBP2 coordinates the function of multiple regulatory mechanisms converging on the actin cytoskeleton Gianluca Cestra, Derek Toomre, Sunghoe Chang, and Pietro De Camilli Proc Natl Acad Sci U S A. 2005 February 1; 102(5): 1731–1736. Published online 2005 January 19. doi: 10.1073/pnas.0409376102.PMCID: PMC547834 Increased activity of cyclin-dependent kinase 5 leads to attenuation of cocaine-mediated dopamine signaling Satoru Takahashi, Toshio Ohshima, Andrew Cho, Taduru Sreenath, Michael J. Iadarola, Harish C. Pant, Yong Kim, Angus C. Nairn, Roscoe O. Brady, Paul Greengard, and Ashok B. Kulkarni Proc Natl Acad Sci U S A. 2005 February 1; 102(5): 1737–1742. Published online 2005 January 21. doi: 10.1073/pnas.0409456102.PMCID: PMC547862 Thalamic Cav3.1 T-type Ca2+ channel plays a crucial role in stabilizing sleep Matthew P. Anderson, Takatoshi Mochizuki, Jinghui Xie, Walter Fischler, Jules P. Manger, Edmund M. Talley, Thomas E. Scammell, and Susumu Tonegawa Proc Natl Acad Sci U S A. 2005 February 1; 102(5): 1743–1748. Published online 2005 January 26. doi: 10.1073/pnas.0409644102.PMCID: PMC547889 DNA methyltransferase 1 regulates reelin mRNA expression in mouse primary cortical cultures Jai Sung Noh, Rajiv P. Sharma, Marin Veldic, Alain A. Salvacion, Xiaomei Jia, Ying Chen, Erminio Costa, Alessandro Guidotti, and Dennis R. Grayson Proc Natl Acad Sci U S A. 2005 February 1; 102(5): 1749–1754. Published online 2005 January 25. doi: 10.1073/pnas.0409648102.PMCID: PMC547890 Pharmacology A cascade of cytokines mediates mechanical inflammatory hypernociception in mice T. M. Cunha, W. A. Verri, Jr., J. S. Silva, S. Poole, F. Q. Cunha, and S. H. Ferreira Proc Natl Acad Sci U S A. 2005 February 1; 102(5): 1755–1760. Published online 2005 January 21. doi: 10.1073/pnas.0409225102.PMCID: PMC547882 Physiology Kisspeptin directly stimulates gonadotropin-releasing hormone release via G protein-coupled receptor 54 Sophie Messager, Emmanouella E. Chatzidaki, Dan Ma, Alan G. Hendrick, Dirk Zahn, John Dixon, Rosemary R. Thresher, Isabelle Malinge, Didier Lomet, Mark B. L. Carlton, William H. Colledge, Alain Caraty, and Samuel A. J. R. Aparicio Proc Natl Acad Sci U S A. 2005 February 1; 102(5): 1761–1766. Published online 2005 January 21. doi: 10.1073/pnas.0409330102.PMCID: PMC545088 Inhibition of cardiac lipoprotein utilization by transgenic overexpression of Angptl4 in the heart Xinxin Yu, Shawn C. Burgess, Hongfei Ge, Kenny K. Wong, R. Haris Nassem, Daniel J. Garry, A. Dean Sherry, Craig R. Malloy, Joel P. Berger, and Cai Li Proc Natl Acad Sci U S A. 2005 February 1; 102(5): 1767–1772. Published online 2005 January 19. doi: 10.1073/pnas.0409564102.PMCID: PMC547881 Plant Biology Structural and biochemical studies identify tobacco SABP2 as a methyl salicylate esterase and implicate it in plant innate immunity Farhad Forouhar, Yue Yang, Dhirendra Kumar, Yang Chen, Eyal Fridman, Sang Wook Park, Yiwen Chiang, Thomas B. Acton, Gaetano T. Montelione, Eran Pichersky, Daniel F. Klessig, and Liang Tong Proc Natl Acad Sci U S A. 2005 February 1; 102(5): 1773–1778. Published online 2005 January 24. doi: 10.1073/pnas.0409227102.PMCID: PMC547883 Metabolic engineering of dhurrin in transgenic Arabidopsis plants with marginal inadvertent effects on the metabolome and transcriptome Charlotte Kristensen, Marc Morant, Carl Erik Olsen, Claus T. Ekstrøm, David W. Galbraith, Birger Lindberg Møller, and Søren Bak Proc Natl Acad Sci U S A. 2005 February 1; 102(5): 1779–1784. Published online 2005 January 21. doi: 10.1073/pnas.0409233102.PMCID: PMC545087 α-Glucan, water dikinase (GWD): A plastidic enzyme with redox-regulated and coordinated catalytic activity and binding affinity René Mikkelsen, Kudzai E. Mutenda, Alexandra Mant, Peter Schürmann, and Andreas Blennow Proc Natl Acad Sci U S A. 2005 February 1; 102(5): 1785–1790. Published online 2005 January 21. doi: 10.1073/pnas.0406674102.PMCID: PMC547843 Pseudomonas syringae manipulates systemic plant defenses against pathogens and herbivores Jianping Cui, Adam K. Bahrami, Elizabeth G. Pringle, Gustavo Hernandez-Guzman, Carol L. Bender, Naomi E. Pierce, and Frederick M. Ausubel Proc Natl Acad Sci U S A. 2005 February 1; 102(5): 1791–1796. Published online 2005 January 18. doi: 10.1073/pnas.0409450102.PMCID: PMC547856 Psychology Fast decay of iconic memory in observers with mild cognitive impairments Zhong-Lin Lu, James Neuse, Stephen Madigan, and Barbara Anne Dosher Proc Natl Acad Sci U S A. 2005 February 1; 102(5): 1797–1802. Published online 2005 January 21. doi: 10.1073/pnas.0408402102.PMCID: PMC547847 Social Sciences Psychology Experiments investigating cooperative types in humans: A complement to evolutionary theory and simulations Robert Kurzban and Daniel Houser Proc Natl Acad Sci U S A. 2005 February 1; 102(5): 1803–1807. Published online 2005 January 21. doi: 10.1073/pnas.0408759102.PMCID: PMC547861 Correction Proc Natl Acad Sci U S A. 2005 February 1; 102(5): 1808. Published online 2005 January 21. doi: 10.1073/pnas.0404043102.PMCID: PMC547814 Corrects: David N. Levy, et al. From the Cover: Dynamics of HIV-1 recombination in its natural target cells. Proc Natl Acad Sci U S A. 2004 March 23; 101(12): 4204–4209. |