| | This journal provides immediate access to some articles. In This Issue Proc Natl Acad Sci U S A. 2005 January 11; 102(2): 251–252. doi: 10.1073/iti0205102.PMCID: PMC544326 Commentary DARPP-32: A molecular switch at the nexus of reward pathway plasticity Todd D. Gould and Husseini K. Manji Proc Natl Acad Sci U S A. 2005 January 11; 102(2): 253–254. Published online 2005 January 4. doi: 10.1073/pnas.0408700102.PMCID: PMC544318 Physical Sciences Chemistry From the Cover: An agent-based approach for modeling molecular self-organization Alessandro Troisi, Vance Wong, and Mark A. Ratner Proc Natl Acad Sci U S A. 2005 January 11; 102(2): 255–260. Published online 2004 December 29. doi: 10.1073/pnas.0408308102.PMCID: PMC544319 Biological spectra analysis: Linking biological activity profiles to molecular structure Anton F. Fliri, William T. Loging, Peter F. Thadeio, and Robert A. Volkmann Proc Natl Acad Sci U S A. 2005 January 11; 102(2): 261–266. Published online 2004 December 29. doi: 10.1073/pnas.0407790101.PMCID: PMC539313 From the Cover: Adhesion at calcium oxalate crystal surfaces and the effect of urinary constituents Xiaoxia Sheng, Taesung Jung, Jeffrey A. Wesson, and Michael D. Ward Proc Natl Acad Sci U S A. 2005 January 11; 102(2): 267–272. Published online 2004 December 29. doi: 10.1073/pnas.0406835101.PMCID: PMC544292 Phosphate forms an unusual tripodal complex with the Fe–Mn center of sweet potato purple acid phosphatase Gerhard Schenk, Lawrence R. Gahan, Lyle E. Carrington, Nataša Mitić, Mohsen Valizadeh, Susan E. Hamilton, John de Jersey, and Luke W. Guddat Proc Natl Acad Sci U S A. 2005 January 11; 102(2): 273–278. Published online 2004 December 29. doi: 10.1073/pnas.0407239102.PMCID: PMC544300 Optical tracking of organically modified silica nanoparticles as DNA carriers: A nonviral, nanomedicine approach for gene delivery Indrajit Roy, Tymish Y. Ohulchanskyy, Dhruba J. Bharali, Haridas E. Pudavar, Ruth A. Mistretta, Navjot Kaur, and Paras N. Prasad Proc Natl Acad Sci U S A. 2005 January 11; 102(2): 279–284. Published online 2005 January 3. doi: 10.1073/pnas.0408039101.PMCID: PMC544309 Biological Sciences Applied Biological Sciences Optical tracking of organically modified silica nanoparticles as DNA carriers: A nonviral, nanomedicine approach for gene delivery Indrajit Roy, Tymish Y. Ohulchanskyy, Dhruba J. Bharali, Haridas E. Pudavar, Ruth A. Mistretta, Navjot Kaur, and Paras N. Prasad Proc Natl Acad Sci U S A. 2005 January 11; 102(2): 279–284. Published online 2005 January 3. doi: 10.1073/pnas.0408039101.PMCID: PMC544309 Biochemistry The effects of upstream DNA on open complex formation by Escherichia coli RNA polymerase Caroline A. Davis, Michael W. Capp, M. Thomas Record, Jr, and Ruth M. Saecker Proc Natl Acad Sci U S A. 2005 January 11; 102(2): 285–290. Published online 2004 December 30. doi: 10.1073/pnas.0405779102.PMCID: PMC544287 Sequence-independent upstream DNA–αCTD interactions strongly stimulate Escherichia coli RNA polymerase-lacUV5 promoter association Wilma Ross and Richard L. Gourse Proc Natl Acad Sci U S A. 2005 January 11; 102(2): 291–296. Published online 2004 December 30. doi: 10.1073/pnas.0405814102.PMCID: PMC544289 The structure of coral allene oxide synthase reveals a catalase adapted for metabolism of a fatty acid hydroperoxide Michael L. Oldham, Alan R. Brash, and Marcia E. Newcomer Proc Natl Acad Sci U S A. 2005 January 11; 102(2): 297–302. Published online 2004 December 29. doi: 10.1073/pnas.0406352102.PMCID: PMC544295 The crystal structure of human adenylate kinase 6: An adenylate kinase localized to the cell nucleus Hui Ren, Liya Wang, Matthew Bennett, Yuhe Liang, Xiaofeng Zheng, Fei Lu, Lanfen Li, Jie Nan, Ming Luo, Staffan Eriksson, Chuanmao Zhang, and Xiao-Dong Su Proc Natl Acad Sci U S A. 2005 January 11; 102(2): 303–308. Published online 2005 January 3. doi: 10.1073/pnas.0407459102.PMCID: PMC544302 Revisiting quorum sensing: Discovery of additional chemical and biological functions for 3-oxo-N-acylhomoserine lactones Gunnar F. Kaufmann, Rafaella Sartorio, Sang-Hyeup Lee, Claude J. Rogers, Michael M. Meijler, Jason A. Moss, Bruce Clapham, Andrew P. Brogan, Tobin J. Dickerson, and Kim D. Janda Proc Natl Acad Sci U S A. 2005 January 11; 102(2): 309–314. Published online 2004 December 27. doi: 10.1073/pnas.0408639102.PMCID: PMC544315 Biophysics Molecular basis for amyloid fibril formation and stability O. Sumner Makin, Edward Atkins, Pawel Sikorski, Jan Johansson, and Louise C. Serpell Proc Natl Acad Sci U S A. 2005 January 11; 102(2): 315–320. Published online 2005 January 3. doi: 10.1073/pnas.0406847102.PMCID: PMC544296 Stochastic simulation of the mammalian circadian clock Daniel B. Forger and Charles S. Peskin Proc Natl Acad Sci U S A. 2005 January 11; 102(2): 321–324. Published online 2004 December 30. doi: 10.1073/pnas.0408465102.PMCID: PMC544301 Power gain exhibited by motile mechanosensory neurons in Drosophila ears M. C. Göpfert, A. D. L. Humphris, J. T. Albert, D. Robert, and O. Hendrich Proc Natl Acad Sci U S A. 2005 January 11; 102(2): 325–330. Published online 2004 December 28. doi: 10.1073/pnas.0405741102.PMCID: PMC544284 Noisy signal amplification in ultrasensitive signal transduction Tatsuo Shibata and Koichi Fujimoto Proc Natl Acad Sci U S A. 2005 January 11; 102(2): 331–336. Published online 2004 December 29. doi: 10.1073/pnas.0403350102.PMCID: PMC544281 Cell Biology DNA replication origins in the Schizosaccharomyces pombe genome Jianli Dai, Ray-Yuan Chuang, and Thomas J. Kelly Proc Natl Acad Sci U S A. 2005 January 11; 102(2): 337–342. Published online 2004 December 28. doi: 10.1073/pnas.0408811102.PMCID: PMC539312 Cell cycle-dependent translocation of PRC1 on the spindle by Kif4 is essential for midzone formation and cytokinesis Changjun Zhu and Wei Jiang Proc Natl Acad Sci U S A. 2005 January 11; 102(2): 343–348. Published online 2004 December 29. doi: 10.1073/pnas.0408438102.PMCID: PMC544298 A-kinase-interacting protein localizes protein kinase A in the nucleus Mira Sastri, David M. Barraclough, Peter T. Carmichael, and Susan S. Taylor Proc Natl Acad Sci U S A. 2005 January 11; 102(2): 349–354. Published online 2005 January 3. doi: 10.1073/pnas.0408608102.PMCID: PMC544310 CD98hc (SLC3A2) mediates integrin signaling Chloe C. Feral, Naoyuki Nishiya, Csilla A. Fenczik, Heidi Stuhlmann, Marina Slepak, and Mark H. Ginsberg Proc Natl Acad Sci U S A. 2005 January 11; 102(2): 355–360. Published online 2004 December 29. doi: 10.1073/pnas.0404852102.PMCID: PMC544283 Developmental Biology Zebrafish GADD45β genes are involved in somite segmentation Atsuo Kawahara, Yong-Suk Che, Ryuki Hanaoka, Hiroyuki Takeda, and Igor B. Dawid Proc Natl Acad Sci U S A. 2005 January 11; 102(2): 361–366. Published online 2004 December 27. doi: 10.1073/pnas.0408726102.PMCID: PMC544321 An embryonic poly(A)-binding protein (ePAB) is expressed in mouse oocytes and early preimplantation embryos Emre Seli, Maria D. Lalioti, Sean M. Flaherty, Denny Sakkas, Nihal Terzi, and Joan A. Steitz Proc Natl Acad Sci U S A. 2005 January 11; 102(2): 367–372. Published online 2005 January 3. doi: 10.1073/pnas.0408378102.PMCID: PMC544294 Evolution Phylogeny determined by protein domain content Song Yang, Russell F. Doolittle, and Philip E. Bourne Proc Natl Acad Sci U S A. 2005 January 11; 102(2): 373–378. Published online 2005 January 3. doi: 10.1073/pnas.0408810102.PMCID: PMC540256 High rate of viral evolution associated with the emergence of carnivore parvovirus Laura A. Shackelton, Colin R. Parrish, Uwe Truyen, and Edward C. Holmes Proc Natl Acad Sci U S A. 2005 January 11; 102(2): 379–384. Published online 2004 December 30. doi: 10.1073/pnas.0406765102.PMCID: PMC544290 Evidence for self-cleaning in gecko setae W. R. Hansen and K. Autumn Proc Natl Acad Sci U S A. 2005 January 11; 102(2): 385–389. Published online 2005 January 3. doi: 10.1073/pnas.0408304102.PMCID: PMC544316 Experimental evolution of conflict mediation between genomes Joel L. Sachs and James J. Bull Proc Natl Acad Sci U S A. 2005 January 11; 102(2): 390–395. Published online 2005 January 3. doi: 10.1073/pnas.0405738102.PMCID: PMC544279 Genetics Hereditary persistence of α-fetoprotein and H19 expression in liver of BALB/cJ mice is due to a retrovirus insertion in the Zhx2 gene Sudhir Perincheri, R. W. Cameron Dingle, Martha L. Peterson, and Brett T. Spear Proc Natl Acad Sci U S A. 2005 January 11; 102(2): 396–401. Published online 2004 December 30. doi: 10.1073/pnas.0408555102.PMCID: PMC544306 Advances in measuring lifespan in the yeast Saccharomyces cerevisiae Nadège Minois, Magdalena Frajnt, Chris Wilson, and James W. Vaupel Proc Natl Acad Sci U S A. 2005 January 11; 102(2): 402–406. Published online 2004 December 29. doi: 10.1073/pnas.0408332102.PMCID: PMC544282 tp53 mutant zebrafish develop malignant peripheral nerve sheath tumors Stéphane Berghmans, Ryan D. Murphey, Erno Wienholds, Donna Neuberg, Jeffery L. Kutok, Christopher D. M. Fletcher, John P. Morris, Ting Xi Liu, Stefan Schulte-Merker, John P. Kanki, Ronald Plasterk, Leonard I. Zon, and A. Thomas Look Proc Natl Acad Sci U S A. 2005 January 11; 102(2): 407–412. Published online 2005 January 3. doi: 10.1073/pnas.0406252102.PMCID: PMC544293 Immunology Partial d-amino acid substitution: Improved enzymatic stability and preserved Ab recognition of a MUC2 epitope peptide Regina Tugyi, Katalin Uray, Dóra Iván, Erzsébet Fellinger, Alan Perkins, and Ferenc Hudecz Proc Natl Acad Sci U S A. 2005 January 11; 102(2): 413–418. Published online 2005 January 3. doi: 10.1073/pnas.0407677102.PMCID: PMC544305 Regulatory T cells suppress tumor-specific CD8 T cell cytotoxicity through TGF-β signals in vivo Mei-Ling Chen, Mikaël J. Pittet, Leonid Gorelik, Richard A. Flavell, Ralph Weissleder, Harald von Boehmer, and Khashayarsha Khazaie Proc Natl Acad Sci U S A. 2005 January 11; 102(2): 419–424. Published online 2004 December 27. doi: 10.1073/pnas.0408197102.PMCID: PMC544311 Medical Sciences Induction, differentiation, and remodeling of blood vessels after transplantation of Bcl-2-transduced endothelial cells David R. Enis, Benjamin R. Shepherd, Yinong Wang, Asif Qasim, Catherine M. Shanahan, Peter L. Weissberg, Michael Kashgarian, Jordan S. Pober, and Jeffrey S. Schechner Proc Natl Acad Sci U S A. 2005 January 11; 102(2): 425–430. Published online 2004 December 29. doi: 10.1073/pnas.0408357102.PMCID: PMC544288 Myeloperoxidase mediates neutrophil activation by association with CD11b/CD18 integrins Denise Lau, Hanke Mollnau, Jason P. Eiserich, Bruce A. Freeman, Andreas Daiber, Ursula M. Gehling, Jens Brümmer, Volker Rudolph, Thomas Münzel, Thomas Heitzer, Thomas Meinertz, and Stephan Baldus Proc Natl Acad Sci U S A. 2005 January 11; 102(2): 431–436. Published online 2004 December 29. doi: 10.1073/pnas.0405193102.PMCID: PMC544285 Inhibition of cardiac myofibroblast formation and collagen synthesis by activation and overexpression of adenylyl cyclase James S. Swaney, David M. Roth, Erik R. Olson, Jennifer E. Naugle, J. Gary Meszaros, and Paul A. Insel Proc Natl Acad Sci U S A. 2005 January 11; 102(2): 437–442. Published online 2004 December 29. doi: 10.1073/pnas.0408704102.PMCID: PMC544320 From the Cover: Ethanol-withdrawal seizures are controlled by tissue plasminogen activator via modulation of NR2B-containing NMDA receptors Robert Pawlak, Jerry P. Melchor, Tomasz Matys, Anna E. Skrzypiec, and Sidney Strickland Proc Natl Acad Sci U S A. 2005 January 11; 102(2): 443–448. Published online 2005 January 3. doi: 10.1073/pnas.0406454102.PMCID: PMC544297 Diagnostic tool for the identification of MLL rearrangements including unknown partner genes Claus Meyer, Bjoern Schneider, Martin Reichel, Sieglinde Angermueller, Sabine Strehl, Susanne Schnittger, Claudia Schoch, Mieke W. J. C. Jansen, Jacques J. van Dongen, Rob Pieters, Oskar A. Haas, Theo Dingermann, Thomas Klingebiel, and Rolf Marschalek Proc Natl Acad Sci U S A. 2005 January 11; 102(2): 449–454. Published online 2004 December 30. doi: 10.1073/pnas.0406994102.PMCID: PMC544299 Normal gating of CFTR requires ATP binding to both nucleotide-binding domains and hydrolysis at the second nucleotide-binding domain Allan L. Berger, Mutsuhiro Ikuma, and Michael J. Welsh Proc Natl Acad Sci U S A. 2005 January 11; 102(2): 455–460. Published online 2004 December 27. doi: 10.1073/pnas.0408575102.PMCID: PMC544308 Microbiology From the Cover: Combinatorial biosynthesis of antitumor indolocarbazole compounds César Sánchez, Lili Zhu, Alfredo F. Braña, Aaroa P. Salas, Jürgen Rohr, Carmen Méndez, and José A. Salas Proc Natl Acad Sci U S A. 2005 January 11; 102(2): 461–466. Published online 2004 December 29. doi: 10.1073/pnas.0407809102.PMCID: PMC544307 S-nitroso proteome of Mycobacterium tuberculosis: Enzymes of intermediary metabolism and antioxidant defense Kyu Y. Rhee, Hediye Erdjument-Bromage, Paul Tempst, and Carl F. Nathan Proc Natl Acad Sci U S A. 2005 January 11; 102(2): 467–472. Published online 2004 December 30. doi: 10.1073/pnas.0406133102.PMCID: PMC544291 Neuroscience Acquired deficit of forebrain glucocorticoid receptor produces depression-like changes in adrenal axis regulation and behavior Maureen P. Boyle, Judson A. Brewer, Michiyo Funatsu, David F. Wozniak, Joe Z. Tsien, Yukitoshi Izumi, and Louis J. Muglia Proc Natl Acad Sci U S A. 2005 January 11; 102(2): 473–478. Published online 2004 December 27. doi: 10.1073/pnas.0406458102.PMCID: PMC544280 Changes in extracellular space size and geometry in APP23 transgenic mice: A model of Alzheimer's disease Eva Syková, Ivan Voříšek, Tatiana Antonova, Tomáš Mazel, Melanie Meyer-Luehmann, Mathias Jucker, Milan Hájek, Michael Or, and Jan Bureš Proc Natl Acad Sci U S A. 2005 January 11; 102(2): 479–484. Published online 2005 January 3. doi: 10.1073/pnas.0408235102.PMCID: PMC544312 Stargazin is an AMPA receptor auxiliary subunit Wim Vandenberghe, Roger A. Nicoll, and David S. Bredt Proc Natl Acad Sci U S A. 2005 January 11; 102(2): 485–490. Published online 2005 January 3. doi: 10.1073/pnas.0408269102.PMCID: PMC544314 From the Cover: Regulation of a protein phosphatase cascade allows convergent dopamine and glutamate signals to activate ERK in the striatum Emmanuel Valjent, Vincent Pascoli, Per Svenningsson, Surojit Paul, Hervé Enslen, Jean-Christophe Corvol, Alexandre Stipanovich, Jocelyne Caboche, Paul J. Lombroso, Angus C. Nairn, Paul Greengard, Denis Hervé, and Jean-Antoine Girault Proc Natl Acad Sci U S A. 2005 January 11; 102(2): 491–496. Published online 2004 December 17. doi: 10.1073/pnas.0408305102.PMCID: PMC544317 Pharmacology Selective up-regulation of PDE1B2 upon monocyte-to-macrophage differentiation Andrew T. Bender, Cari L. Ostenson, Edith H. Wang, and Joseph A. Beavo Proc Natl Acad Sci U S A. 2005 January 11; 102(2): 497–502. Published online 2004 December 29. doi: 10.1073/pnas.0408535102.PMCID: PMC544304 Physiology Pax2 expression occurs in renal medullary epithelial cells in vivo and in cell culture, is osmoregulated, and promotes osmotic tolerance Qi Cai, Natalia I. Dmitrieva, Joan D. Ferraris, Heddwen L. Brooks, Bas W. M. van Balkom, and Maurice Burg Proc Natl Acad Sci U S A. 2005 January 11; 102(2): 503–508. Published online 2004 December 27. doi: 10.1073/pnas.0408840102.PMCID: PMC544323 Plant Biology Pea DNA helicase 45 overexpression in tobacco confers high salinity tolerance without affecting yield Neeti Sanan-Mishra, Xuan Hoi Pham, Sudhir K. Sopory, and Narendra Tuteja Proc Natl Acad Sci U S A. 2005 January 11; 102(2): 509–514. Published online 2005 January 3. doi: 10.1073/pnas.0406485102.PMCID: PMC544286 Corrections Proc Natl Acad Sci U S A. 2005 January 11; 102(2): 515. Published online 2004 December 30. doi: 10.1073/pnas.0408627101.PMCID: PMC544313 Corrects: R. C. Marians, et al. Defining thyrotropin-dependent and -independent steps of thyroid hormone synthesis by using thyrotropin receptor-null mice. Proc Natl Acad Sci U S A. 2002 November 26; 99(24): 15776–15781. Proc Natl Acad Sci U S A. 2005 January 11; 102(2): 515. Published online 2004 December 28. doi: 10.1073/pnas.0408763101.PMCID: PMC544322 Corrects: Christian Laforsch, et al. An acoustic microscopy technique reveals hidden morphological defenses in Daphnia. Proc Natl Acad Sci U S A. 2004 November 9; 101(45): 15911–15914. Proc Natl Acad Sci U S A. 2005 January 11; 102(2): 515. Published online 2004 December 28. doi: 10.1073/pnas.0408916101.PMCID: PMC544324 Corrects: Xiaoqing Liu, et al. From the Cover: AIPL1, the protein that is defective in Leber congenital amaurosis, is essential for the biosynthesis of retinal rod cGMP phosphodiesterase. Proc Natl Acad Sci U S A. 2004 September 21; 101(38): 13903–13908. Retractions Doug Bassett, James C. Morrell, Gregory J. Gatto, Jr., Jianwu Bai, Brian V. Geisbrecht, Phil Hieter, and Stephen J. Gould Proc Natl Acad Sci U S A. 2005 January 11; 102(2): 516. Published online 2004 December 30. doi: 10.1073/pnas.0407487101.PMCID: PMC544303 Retracts: Michael T. Geraghty, et al. Detecting patterns of protein distribution and gene expression in silico. Proc Natl Acad Sci U S A. 1999 March 16; 96(6): 2937–2942. Cory L. Grand, Tiffanie J. Powell, Raymond B. Nagle, David J. Bearss, Denise Tye, Mary Gleason-Guzman, and Laurence H. Hurley Proc Natl Acad Sci U S A. 2005 January 11; 102(2): 516. Published online 2004 December 29. doi: 10.1073/pnas.0408999101.PMCID: PMC544325 Retracts: Cory L. Grand, et al. Mutations in the G-quadruplex silencer element and their relationship to c-MYC overexpression, NM23 repression, and therapeutic rescue. Proc Natl Acad Sci U S A. 2004 April 20; 101(16): 6140–6145. |