| | This journal provides immediate access to some articles. Commentaries Getting protein solvent structures down cold B. Leif Hanson PMCID: PMC534549 Germ-line immortality Martin M. Matzuk PMCID: PMC534540 Defining the function of a prolactin gene family member Jonathan A. Green PMCID: PMC534523 An atomic-resolution mechanism of 3-hydroxy-3-methylglutaryl–CoA synthase Brian J. Bahnson PMCID: PMC534547 Synaptotagmin promotes both vesicle fusion and recycling Thomas L. Schwarz PMCID: PMC534545 NO and superoxide: Opposite ends of the seesaw in cardiac contractility Joseph Bonaventura and Andrew Gow PMCID: PMC534506 Physical Sciences Applied Mathematics Integrative analysis of genome-scale data by using pseudoinverse projection predicts novel correlation between DNA replication and RNA transcription Orly Alter and Gene H. Golub PMCID: PMC534520 Chemistry From the Cover:
The 15-K neutron structure of saccharide-free concanavalin A M. P. Blakeley, A. J. Kalb (Gilboa), J. R. Helliwell, and D. A. A. Myles PMCID: PMC534515 Geophysics Climate change impacts are sensitive to the concentration stabilization path Brian C. O'Neill and Michael Oppenheimer PMCID: PMC534524 Mathematics Partitions with difference conditions and Alder's conjecture Ae Ja Yee PMCID: PMC534528 Biological Sciences Biochemistry Reversible oxidation and inactivation of the tumor suppressor PTEN in cells stimulated with peptide growth factors Jaeyul Kwon, Seung-Rock Lee, Kap-Seok Yang, Younghee Ahn, Yeun Ju Kim, Earl R. Stadtman, and Sue Goo Rhee PMCID: PMC534546 TATA box binding protein induces structure in the recombinant glucocorticoid receptor AF1 domain Raj Kumar, David E. Volk, Jianquan Li, James C. Lee, David G. Gorenstein, and E. Brad Thompson PMCID: PMC534534 Structure and function of the phenazine biosynthetic protein PhzF from Pseudomonas fluorescens Wulf Blankenfeldt, Alexandre P. Kuzin, Tatiana Skarina, Yuriy Korniyenko, Liang Tong, Peter Bayer, Petra Janning, Linda S. Thomashow, and Dmitri V. Mavrodi PMCID: PMC534541 Remote hot spots mediate protein substrate recognition for the Cdc25 phosphatase J. Sohn, K. Kristjánsdóttir, A. Safi, B. Parker, B. Kiburz, and J. Rudolph PMCID: PMC534539 From the Cover:
3-hydroxy-3-methylglutaryl–CoA synthase intermediate complex observed in “real-time” Michael J. Theisen, Ila Misra, Dana Saadat, Nino Campobasso, Henry M. Miziorko, and David H. T. Harrison PMCID: PMC534525 Mimicking enzyme evolution by generating new (βα)8-barrels from (βα)4-half-barrels Birte Höcker, Jörg Claren, and Reinhard Sterner PMCID: PMC534502 Unraveling the interface of signal recognition particle and its receptor by using chemical cross-linking and tandem mass spectrometry Feixia Chu, Shu-ou Shan, Demetri T. Moustakas, Frank Alber, Pascal F. Egea, Robert M. Stroud, Peter Walter, and Alma L. Burlingame PMCID: PMC528904 Medicinal chemistry applied to a synthetic protein: Development of highly potent HIV entry inhibitors Oliver Hartley, Hubert Gaertner, Jill Wilken, Darren Thompson, Richard Fish, Alejandra Ramos, Cristina Pastore, Brigitte Dufour, Fabrice Cerini, Astrid Melotti, Nikolaus Heveker, Laurent Picard, Marc Alizon, Donald Mosier, Stephen Kent, and Robin Offord PMCID: PMC534511 Biophysics α-Synuclein structures from fluorescence energy-transfer kinetics: Implications for the role of the protein in Parkinson's disease Jennifer C. Lee, Ralf Langen, Patrick A. Hummel, Harry B. Gray, and Jay R. Winkler PMCID: PMC534538 Trans-bonded pairs of E-cadherin exhibit a remarkable hierarchy of mechanical strengths E. Perret, A. Leung, H. Feracci, and E. Evans PMCID: PMC534503 α,β hybrid peptides: A polypeptide helix with a central segment containing two consecutive β-amino acid residues Rituparna S. Roy, Isabella L. Karle, S. Raghothama, and P. Balaram PMCID: PMC534522 Cell Biology The role of the glycocalyx in reorganization of the actin cytoskeleton under fluid shear stress: A “bumper-car” model Mia M. Thi, John M. Tarbell, Sheldon Weinbaum, and David C. Spray PMCID: PMC534550 Growth factors essential for self-renewal and expansion of mouse spermatogonial stem cells Hiroshi Kubota, Mary R. Avarbock, and Ralph L. Brinster PMCID: PMC534530 Long-range compaction and flexibility of interphase chromatin in budding yeast analyzed by high-resolution imaging techniques Kerstin Bystricky, Patrick Heun, Lutz Gehlen, Jörg Langowski, and Susan M. Gasser PMCID: PMC534505 Glyceraldehyde 3-phosphate dehydrogenase-S, a sperm-specific glycolytic enzyme, is required for sperm motility and male fertility Kiyoshi Miki, Weidong Qu, Eugenia H. Goulding, William D. Willis, Donna O. Bunch, Lillian F. Strader, Sally D. Perreault, Edward M. Eddy, and Deborah A. O'Brien PMCID: PMC534542 Mitochondrial biogenesis by NO yields functionally active mitochondria in mammals Enzo Nisoli, Sestina Falcone, Cristina Tonello, Valeria Cozzi, Letizia Palomba, Mara Fiorani, Addolorata Pisconti, Silvia Brunelli, Annalisa Cardile, Maura Francolini, Orazio Cantoni, Michele O. Carruba, Salvador Moncada, and Emilio Clementi PMCID: PMC534517 Fluorescent indicators of cAMP and Epac activation reveal differential dynamics of cAMP signaling within discrete subcellular compartments Lisa M. DiPilato, Xiaodong Cheng, and Jin Zhang PMCID: PMC534508 A mitotic kinesin-like protein required for normal karyokinesis, myosin localization to the furrow, and cytokinesis in Dictyostelium Gandikota S. Lakshmikanth, Hans M. Warrick, and James A. Spudich PMCID: PMC528903 Distinct pathways of insulin-regulated versus diabetes-regulated gene expression: An in vivo analysis in MIRKO mice Vijay K. Yechoor, Mary-Elizabeth Patti, Kohjiro Ueki, Palle G. Laustsen, Robert Saccone, Ravi Rauniyar, and C. Ronald Kahn PMCID: PMC534529 LIM domains-containing protein 1 (LIMD1), a tumor suppressor encoded at chromosome 3p21.3, binds pRB and represses E2F-driven transcription Tyson V. Sharp, Fernando Munoz, Dimitra Bourboulia, Nadege Presneau, Eva Darai, Hsei-Wei Wang, Mark Cannon, David N. Butcher, Andrew G. Nicholson, George Klein, Stephan Imreh, and Chris Boshoff PMCID: PMC534532 Recruitment of IκBα to the hes1 promoter is associated with transcriptional repression Cristina Aguilera, Ruben Hoya-Arias, Guy Haegeman, Lluís Espinosa, and Anna Bigas PMCID: PMC534509 Developmental Biology From the Cover:
A prolactin family paralog regulates reproductive adaptations to a physiological stressor Rupasri Ain, Guoli Dai, Judy H. Dunmore, Alan R. Godwin, and Michael J. Soares PMCID: PMC534510 Lhx2–/– mice develop liver fibrosis Ewa Wandzioch, Åsa Kolterud, Maria Jacobsson, Scott L. Friedman, and Leif Carlsson PMCID: PMC526277 Evolution Molecular evolution of dinoflagellate luciferases, enzymes with three catalytic domains in a single polypeptide Liyun Liu, Thérèse Wilson, and J. Woodland Hastings PMCID: PMC534537 Ultraviolet plumage reflectance distinguishes sibling bird species Robert Bleiweiss PMCID: PMC534516 Araceae from the Early Cretaceous of Portugal: Evidence on the emergence of monocotyledons Else Marie Friis, Kaj Raunsgaard Pedersen, and Peter R. Crane PMCID: PMC534535 On the evolutionary history of Ephedra: Cretaceous fossils and extant molecules Catarina Rydin, Kaj Raunsgaard Pedersen, and Else Marie Friis PMCID: PMC534533 Genetics Integrative analysis of genome-scale data by using pseudoinverse projection predicts novel correlation between DNA replication and RNA transcription Orly Alter and Gene H. Golub PMCID: PMC534520 Dynamic histone modifications mark sex chromosome inactivation and reactivation during mammalian spermatogenesis Ahmad M. Khalil, Fatih Z. Boyar, and Daniel J. Driscoll PMCID: PMC534513 Bbs2-null mice have neurosensory deficits, a defect in social dominance, and retinopathy associated with mislocalization of rhodopsin Darryl Y. Nishimura, Melissa Fath, Robert F. Mullins, Charles Searby, Michael Andrews, Roger Davis, Jeaneen L. Andorf, Kirk Mykytyn, Ruth E. Swiderski, Baoli Yang, Rivka Carmi, Edwin M. Stone, and Val C. Sheffield PMCID: PMC534519 Finding new components of the target of rapamycin (TOR) signaling network through chemical genetics and proteome chips Jing Huang, Heng Zhu, Stephen J. Haggarty, David R. Spring, Heejun Hwang, Fulai Jin, Michael Snyder, and Stuart L. Schreiber PMCID: PMC527135 Immunology TNF receptor-associated factor (TRAF) domain and Bcl-2 cooperate to induce small B cell lymphoma/chronic lymphocytic leukemia in transgenic mice Juan M. Zapata, Maryla Krajewska, Herbert C. Morse, III, Yongwon Choi, and John C. Reed PMCID: PMC534512 Distinct roles of IL-12 and IL-15 in human natural killer cell activation by dendritic cells from secondary lymphoid organs Guido Ferlazzo, Maggi Pack, Dolca Thomas, Casper Paludan, Dorothee Schmid, Till Strowig, Gwenola Bougras, William A. Muller, Lorenzo Moretta, and Christian Münz PMCID: PMC534504 Activation of RasGRP3 by phosphorylation of Thr-133 is required for B cell receptor-mediated Ras activation Yuichi Aiba, Masatsugu Oh-hora, Shigeki Kiyonaka, Yayoi Kimura, Atsushi Hijikata, Yasuo Mori, and Tomohiro Kurosaki PMCID: PMC528733 Medical Sciences Estrogen prevents bone loss through transforming growth factor β signaling in T cells Yuhao Gao, Wei-Ping Qian, Kimberly Dark, Gianluca Toraldo, Angela S. P. Lin, Robert E. Guldberg, Richard A. Flavell, M. Neale Weitzmann, and Roberto Pacifici PMCID: PMC534514 Microbiology A genetic screen to isolate type III effectors translocated into pepper cells during Xanthomonas infection Julie Anne Roden, Brandis Belt, Jason Barzel Ross, Thomas Tachibana, Joe Vargas, and Mary Beth Mudgett PMCID: PMC534543 From the Cover:
Self-generated diversity produces “insurance effects” in biofilm communities Blaise R. Boles, Matthew Thoendel, and Pradeep K. Singh PMCID: PMC528905 A dual-genome Symbiosis Chip for coordinate study of signal exchange and development in a prokaryote–host interaction Melanie J. Barnett, Carol J. Toman, Robert F. Fisher, and Sharon R. Long PMCID: PMC527922 Human cytomegalovirus encodes a highly specific RANTES decoy receptor Dai Wang, Wade Bresnahan, and Thomas Shenk PMCID: PMC534536 Neuroscience From the Cover:
Kinetic efficiency of endocytosis at mammalian CNS synapses requires synaptotagmin I Karin Nicholson-Tomishima and Timothy A. Ryan PMCID: PMC534526 Identification and functional characterization of a sex pheromone receptor in the silkmoth Bombyx mori Takeshi Sakurai, Takao Nakagawa, Hidefumi Mitsuno, Hajime Mori, Yasuhisa Endo, Shintarou Tanoue, Yuji Yasukochi, Kazushige Touhara, and Takaaki Nishioka PMCID: PMC528734 Histone deacetylase inhibition-mediated neuronal differentiation of multipotent adult neural progenitor cells Jenny Hsieh, Kinichi Nakashima, Tomoko Kuwabara, Eunice Mejia, and Fred H. Gage PMCID: PMC527137 Transient expansion of synaptically connected dendritic spines upon induction of hippocampal long-term potentiation Cynthia Lang, Angel Barco, Leonard Zablow, Eric R. Kandel, Steven A. Siegelbaum, and Stanislav S. Zakharenko PMCID: PMC534531 Pharmacology Reduced cGMP signaling associated with neointimal proliferation and vascular dysfunction in late-stage atherosclerosis Volker O. Melichar, Delphine Behr-Roussel, Ulrike Zabel, L. Otto Uttenthal, José Rodrigo, Alain Rupin, Tony J. Verbeuren, Arun Kumar H. S., and Harald H. H. W. Schmidt PMCID: PMC534521 Gestational exposure of Ahr and Arnt hypomorphs to dioxin rescues vascular development Jacqueline A. Walisser, Maureen K. Bunger, Edward Glover, and Christopher A. Bradfield PMCID: PMC534507 Physiology Sarco(endo)plasmic reticulum Ca2+ ATPase (SERCA) gene silencing and remodeling of the Ca2+ signaling mechanism in cardiac myocytes M. Seth, C. Sumbilla, S. P. Mullen, D. Lewis, M. G. Klein, A. Hussain, J. Soboloff, D. L. Gill, and G. Inesi PMCID: PMC528906 Mechanotransduction and strain amplification in osteocyte cell processes Yuefeng Han, Stephen C. Cowin, Mitchell B. Schaffler, and Sheldon Weinbaum PMCID: PMC534548 Impaired adrenal stress response in Toll-like receptor 2-deficient mice Stefan R. Bornstein, Paula Zacharowski, Ralf R. Schumann, Andreas Barthel, Nguyen Tran, Claudia Papewalis, Valeria Rettori, Samuel M. McCann, Klaus Schulze-Osthoff, Werner A. Scherbaum, Jörg Tarnow, and Kai Zacharowski PMCID: PMC534518 Psychology Fear fosters flight: A mechanism for fear contagion when perceiving emotion expressed by a whole body Beatrice de Gelder, Josh Snyder, Doug Greve, George Gerard, and Nouchine Hadjikhani PMCID: PMC528902 Corrections Proc Natl Acad Sci U S A. 2004 November 23; 101(47): 16707. doi: 10.1073/pnas.0407571101.PMCID: PMC534527 Corrects: Katayoon H. Emami, et al. A small molecule inhibitor of β-catenin/cyclic AMP response element-binding protein transcription. Proc Natl Acad Sci U S A. 2004 August 24; 101(34): 12682–12687. Proc Natl Acad Sci U S A. 2004 November 23; 101(47): 16707. doi: 10.1073/pnas.0407769101.PMCID: PMC534544 Corrects: Joseph M. Scandura, et al. Transforming growth factor β-induced cell cycle arrest of human hematopoietic cells requires p57KIP2 up-regulation. Proc Natl Acad Sci U S A. 2004 October 19; 101(42): 15231–15236. |
