| | This journal provides immediate access to some articles. Commentary The privileged status of emotion in the brain Richard J. Davidson, Jeffrey S. Maxwell, and Alexander J. Shackman Proc Natl Acad Sci U S A. 2004 August 17; 101(33): 11915–11916. Published online 2004 August 10. doi: 10.1073/pnas.0404264101.PMCID: PMC514407 Natural Product Synthesis Special Feature Research Articles A concise, total synthesis of the TMC-95A/B proteasome inhibitors Brian K. Albrecht and Robert M. Williams Proc Natl Acad Sci U S A. 2004 August 17; 101(33): 11949–11954. Published online 2004 May 26. doi: 10.1073/pnas.0308432101.PMCID: PMC514414 Total synthesis of (–)-spinosyn A Dustin J. Mergott, Scott A. Frank, and William R. Roush Proc Natl Acad Sci U S A. 2004 August 17; 101(33): 11955–11959. Published online 2004 June 1. doi: 10.1073/pnas.0401247101.PMCID: PMC514415 Catalysis-based enantioselective total synthesis of the macrocyclic spermidine alkaloid isooncinotine Bodo Scheiper, Frank Glorius, Andreas Leitner, and Alois Fürstner Proc Natl Acad Sci U S A. 2004 August 17; 101(33): 11960–11965. Published online 2004 May 12. doi: 10.1073/pnas.0401322101.PMCID: PMC514416 Stereocontrolled total synthesis of (+)-vincristine Takeshi Kuboyama, Satoshi Yokoshima, Hidetoshi Tokuyama, and Tohru Fukuyama Proc Natl Acad Sci U S A. 2004 August 17; 101(33): 11966–11970. Published online 2004 May 12. doi: 10.1073/pnas.0401323101.PMCID: PMC514417 Synthetic studies of roquefortine C: Synthesis of isoroquefortine C and a heterocycle David J. Richard, Bruno Schiavi, and Madeleine M. Joullié Proc Natl Acad Sci U S A. 2004 August 17; 101(33): 11971–11976. Published online 2004 May 12. doi: 10.1073/pnas.0401407101.PMCID: PMC514418 Total synthesis and structure of the ramoplanin A1 and A3 aglycons: Two minor components of the ramoplanin complex Dongwoo Shin, Yosup Rew, and Dale L. Boger Proc Natl Acad Sci U S A. 2004 August 17; 101(33): 11977–11979. Published online 2004 June 2. doi: 10.1073/pnas.0401419101.PMCID: PMC514419 Toward the synthesis of the carbacylic ansa antibiotic kendomycin Johann Mulzer, Stefan Pichlmair, Martin P. Green, Maria M. B. Marques, and Harry J. Martin Proc Natl Acad Sci U S A. 2004 August 17; 101(33): 11980–11985. Published online 2004 July 26. doi: 10.1073/pnas.0401503101.PMCID: PMC514420 Synthesis of antimicrofilament marine macrolides: Synthesis and configurational assignment of a C5–C16 degradation fragment of reidispongiolide A Ian Paterson, Robert Britton, Kate Ashton, Henner Knust, and Jonathan Stafford Proc Natl Acad Sci U S A. 2004 August 17; 101(33): 11986–11991. Published online 2004 June 16. doi: 10.1073/pnas.0401548101.PMCID: PMC514421 A unified approach to polyene macrolides: Synthesis of candidin and nystatin polyols Isao Kadota, Yueqing Hu, Garrick K. Packard, and Scott D. Rychnovsky Proc Natl Acad Sci U S A. 2004 August 17; 101(33): 11992–11995. Published online 2004 June 10. doi: 10.1073/pnas.0401552101.PMCID: PMC514422 Total synthesis of the cytotoxic cyclodepsipeptide (-)-doliculide: The “ester” effect in acyclic 1,3-induction of deoxypropionates Stephen Hanessian, Vincent Mascitti, and Simon Giroux Proc Natl Acad Sci U S A. 2004 August 17; 101(33): 11996–12001. Published online 2004 June 21. doi: 10.1073/pnas.0401637101.PMCID: PMC514423 Oligomeric catechins: An enabling synthetic strategy by orthogonal activation and C(8) protection Ken Ohmori, Naoko Ushimaru, and Keisuke Suzuki Proc Natl Acad Sci U S A. 2004 August 17; 101(33): 12002–12007. Published online 2004 May 12. doi: 10.1073/pnas.0401651101.PMCID: PMC514424 Stereoisomer libraries: Total synthesis of all 16 stereoisomers of the pine sawfly sex pheromone by a fluorous mixture-synthesis approach Sivaraman Dandapani, Mario Jeske, and Dennis P. Curran Proc Natl Acad Sci U S A. 2004 August 17; 101(33): 12008–12012. Published online 2004 May 24. doi: 10.1073/pnas.0401677101.PMCID: PMC514425 First- and second-generation total synthesis of ciguatoxin CTX3C Masayuki Inoue, Keisuke Miyazaki, Hisatoshi Uehara, Megumi Maruyama, and Masahiro Hirama Proc Natl Acad Sci U S A. 2004 August 17; 101(33): 12013–12018. Published online 2004 June 15. doi: 10.1073/pnas.0401684101.PMCID: PMC514426 The total synthesis of (–)-crispatene Aubry K. Miller, Daniel H. Byun, Christopher M. Beaudry, and Dirk Trauner Proc Natl Acad Sci U S A. 2004 August 17; 101(33): 12019–12023. Published online 2004 July 23. doi: 10.1073/pnas.0401787101.PMCID: PMC514427 A total synthesis of estrone based on a novel cascade of radical cyclizations Gerald Pattenden, Miguel A. Gonzalez, Stuart McCulloch, Affo Walter, and Steven J. Woodhead Proc Natl Acad Sci U S A. 2004 August 17; 101(33): 12024–12029. Published online 2004 August 10. doi: 10.1073/pnas.0401925101.PMCID: PMC514428 Unified synthesis of caged Garcinia natural products based on a site-selective Claisen/Diels–Alder/Claisen rearrangement Eric J. Tisdale, Irina Slobodov, and Emmanuel A. Theodorakis Proc Natl Acad Sci U S A. 2004 August 17; 101(33): 12030–12035. Published online 2004 June 21. doi: 10.1073/pnas.0401932101.PMCID: PMC514429 Synthesis of (-)-longithorone A: Using organic synthesis to probe a proposed biosynthesis Carl A. Morales, Mark E. Layton, and Matthew D. Shair Proc Natl Acad Sci U S A. 2004 August 17; 101(33): 12036–12041. Published online 2004 June 9. doi: 10.1073/pnas.0401952101.PMCID: PMC514430 A unified approach to the tedanolides: Total synthesis of (+)-13-deoxytedanolide Amos B. Smith, III, Christopher M. Adams, Stephanie A. Lodise Barbosa, and Andrew P. Degnan Proc Natl Acad Sci U S A. 2004 August 17; 101(33): 12042–12047. Published online 2004 May 26. doi: 10.1073/pnas.0402084101.PMCID: PMC514431 An enantioselective, modular, and general route to the cytochalasins: Synthesis of L-696,474 and cytochalasin B Andrew M. Haidle and Andrew G. Myers Proc Natl Acad Sci U S A. 2004 August 17; 101(33): 12048–12053. Published online 2004 June 18. doi: 10.1073/pnas.0402111101.PMCID: PMC514432 Efficient construction of the securine A carbon skeleton Peter Korakas, Stuart Chaffee, J. Brad Shotwell, Pamela Duque, and John L. Wood Proc Natl Acad Sci U S A. 2004 August 17; 101(33): 12054–12057. Published online 2004 July 27. doi: 10.1073/pnas.0402274101.PMCID: PMC514433 Studies of stereocontrolled allylation reactions for the total synthesis of phorboxazole A David R. Williams, Andre A. Kiryanov, Ulrich Emde, Michael P. Clark, Martin A. Berliner, and Jonathan T. Reeves Proc Natl Acad Sci U S A. 2004 August 17; 101(33): 12058–12063. Published online 2004 July 26. doi: 10.1073/pnas.0402477101.PMCID: PMC514434 A nucleophile-catalyzed cycloisomerization permits a concise synthesis of (+)-harziphilone Lucy M. Stark, Klaus Pekari, and Erik J. Sorensen Proc Natl Acad Sci U S A. 2004 August 17; 101(33): 12064–12066. Published online 2004 July 1. doi: 10.1073/pnas.0402563101.PMCID: PMC514435 Total synthesis of the marine cyanobacterial cyclodepsipeptide apratoxin A Jiehao Chen and Craig J. Forsyth Proc Natl Acad Sci U S A. 2004 August 17; 101(33): 12067–12072. Published online 2004 July 1. doi: 10.1073/pnas.0402752101.PMCID: PMC514436 Synthesis of the thapsigargins Steven V. Ley, Alessandra Antonello, Emily P. Balskus, David T. Booth, Søren B. Christensen, Ed Cleator, Helen Gold, Klemens Högenauer, Udo Hünger, Rebecca M. Myers, Steven F. Oliver, Oliver Simic, Martin D. Smith, Helmer Søhoel, and Alison J. A. Woolford Proc Natl Acad Sci U S A. 2004 August 17; 101(33): 12073–12078. Published online 2004 June 28. doi: 10.1073/pnas.0403300101.PMCID: PMC514437 Total synthesis of (±)-halichlorine, (±)-pinnaic acid, and (±)-tauropinnaic acid Hamish S. Christie and Clayton H. Heathcock Proc Natl Acad Sci U S A. 2004 August 17; 101(33): 12079–12084. Published online 2004 August 6. doi: 10.1073/pnas.0403887101.PMCID: PMC514438 Editorial The art and science of constructing the molecules of nature K. C. Nicolaou Proc Natl Acad Sci U S A. 2004 August 17; 101(33): 11928. doi: 10.1073/pnas.0405104101.PMCID: PMC514410 Perspective From the Cover: Natural Product Synthesis Special Feature: The essence of total synthesis K. C. Nicolaou and Scott A. Snyder Proc Natl Acad Sci U S A. 2004 August 17; 101(33): 11929–11936. Published online 2004 August 9. doi: 10.1073/pnas.0403799101.PMCID: PMC514411 Prospects for total synthesis: A vision for a totally synthetic vaccine targeting epithelial tumors Stacy J. Keding and Samuel J. Danishefsky Proc Natl Acad Sci U S A. 2004 August 17; 101(33): 11937–11942. Published online 2004 July 27. doi: 10.1073/pnas.0401894101.PMCID: PMC514412 Contiguous stereogenic quaternary carbons: A daunting challenge in natural products synthesis Emily A. Peterson and Larry E. Overman Proc Natl Acad Sci U S A. 2004 August 17; 101(33): 11943–11948. Published online 2004 July 1. doi: 10.1073/pnas.0402416101.PMCID: PMC514413 Physical Sciences Applied Mathematics Efficient system-wide coordination in noisy environments André A. Moreira, Abhishek Mathur, Daniel Diermeier, and Luís A. N. Amaral Proc Natl Acad Sci U S A. 2004 August 17; 101(33): 12085–12090. Published online 2004 August 5. doi: 10.1073/pnas.0400672101.PMCID: PMC514439 Applied Physical Sciences Quasiclassical computation F. Remacle and R. D. Levine Proc Natl Acad Sci U S A. 2004 August 17; 101(33): 12091–12095. Published online 2004 August 5. doi: 10.1073/pnas.0403871101.PMCID: PMC514440 Chemistry A concise, total synthesis of the TMC-95A/B proteasome inhibitors Brian K. Albrecht and Robert M. Williams Proc Natl Acad Sci U S A. 2004 August 17; 101(33): 11949–11954. Published online 2004 May 26. doi: 10.1073/pnas.0308432101.PMCID: PMC514414 Total synthesis of (–)-spinosyn A Dustin J. Mergott, Scott A. Frank, and William R. Roush Proc Natl Acad Sci U S A. 2004 August 17; 101(33): 11955–11959. Published online 2004 June 1. doi: 10.1073/pnas.0401247101.PMCID: PMC514415 Catalysis-based enantioselective total synthesis of the macrocyclic spermidine alkaloid isooncinotine Bodo Scheiper, Frank Glorius, Andreas Leitner, and Alois Fürstner Proc Natl Acad Sci U S A. 2004 August 17; 101(33): 11960–11965. Published online 2004 May 12. doi: 10.1073/pnas.0401322101.PMCID: PMC514416 Stereocontrolled total synthesis of (+)-vincristine Takeshi Kuboyama, Satoshi Yokoshima, Hidetoshi Tokuyama, and Tohru Fukuyama Proc Natl Acad Sci U S A. 2004 August 17; 101(33): 11966–11970. Published online 2004 May 12. doi: 10.1073/pnas.0401323101.PMCID: PMC514417 Synthetic studies of roquefortine C: Synthesis of isoroquefortine C and a heterocycle David J. Richard, Bruno Schiavi, and Madeleine M. Joullié Proc Natl Acad Sci U S A. 2004 August 17; 101(33): 11971–11976. Published online 2004 May 12. doi: 10.1073/pnas.0401407101.PMCID: PMC514418 Total synthesis and structure of the ramoplanin A1 and A3 aglycons: Two minor components of the ramoplanin complex Dongwoo Shin, Yosup Rew, and Dale L. Boger Proc Natl Acad Sci U S A. 2004 August 17; 101(33): 11977–11979. Published online 2004 June 2. doi: 10.1073/pnas.0401419101.PMCID: PMC514419 Toward the synthesis of the carbacylic ansa antibiotic kendomycin Johann Mulzer, Stefan Pichlmair, Martin P. Green, Maria M. B. Marques, and Harry J. Martin Proc Natl Acad Sci U S A. 2004 August 17; 101(33): 11980–11985. Published online 2004 July 26. doi: 10.1073/pnas.0401503101.PMCID: PMC514420 Synthesis of antimicrofilament marine macrolides: Synthesis and configurational assignment of a C5–C16 degradation fragment of reidispongiolide A Ian Paterson, Robert Britton, Kate Ashton, Henner Knust, and Jonathan Stafford Proc Natl Acad Sci U S A. 2004 August 17; 101(33): 11986–11991. Published online 2004 June 16. doi: 10.1073/pnas.0401548101.PMCID: PMC514421 A unified approach to polyene macrolides: Synthesis of candidin and nystatin polyols Isao Kadota, Yueqing Hu, Garrick K. Packard, and Scott D. Rychnovsky Proc Natl Acad Sci U S A. 2004 August 17; 101(33): 11992–11995. Published online 2004 June 10. doi: 10.1073/pnas.0401552101.PMCID: PMC514422 Total synthesis of the cytotoxic cyclodepsipeptide (-)-doliculide: The “ester” effect in acyclic 1,3-induction of deoxypropionates Stephen Hanessian, Vincent Mascitti, and Simon Giroux Proc Natl Acad Sci U S A. 2004 August 17; 101(33): 11996–12001. Published online 2004 June 21. doi: 10.1073/pnas.0401637101.PMCID: PMC514423 Oligomeric catechins: An enabling synthetic strategy by orthogonal activation and C(8) protection Ken Ohmori, Naoko Ushimaru, and Keisuke Suzuki Proc Natl Acad Sci U S A. 2004 August 17; 101(33): 12002–12007. Published online 2004 May 12. doi: 10.1073/pnas.0401651101.PMCID: PMC514424 Stereoisomer libraries: Total synthesis of all 16 stereoisomers of the pine sawfly sex pheromone by a fluorous mixture-synthesis approach Sivaraman Dandapani, Mario Jeske, and Dennis P. Curran Proc Natl Acad Sci U S A. 2004 August 17; 101(33): 12008–12012. Published online 2004 May 24. doi: 10.1073/pnas.0401677101.PMCID: PMC514425 First- and second-generation total synthesis of ciguatoxin CTX3C Masayuki Inoue, Keisuke Miyazaki, Hisatoshi Uehara, Megumi Maruyama, and Masahiro Hirama Proc Natl Acad Sci U S A. 2004 August 17; 101(33): 12013–12018. Published online 2004 June 15. doi: 10.1073/pnas.0401684101.PMCID: PMC514426 The total synthesis of (–)-crispatene Aubry K. Miller, Daniel H. Byun, Christopher M. Beaudry, and Dirk Trauner Proc Natl Acad Sci U S A. 2004 August 17; 101(33): 12019–12023. Published online 2004 July 23. doi: 10.1073/pnas.0401787101.PMCID: PMC514427 A total synthesis of estrone based on a novel cascade of radical cyclizations Gerald Pattenden, Miguel A. Gonzalez, Stuart McCulloch, Affo Walter, and Steven J. Woodhead Proc Natl Acad Sci U S A. 2004 August 17; 101(33): 12024–12029. Published online 2004 August 10. doi: 10.1073/pnas.0401925101.PMCID: PMC514428 Unified synthesis of caged Garcinia natural products based on a site-selective Claisen/Diels–Alder/Claisen rearrangement Eric J. Tisdale, Irina Slobodov, and Emmanuel A. Theodorakis Proc Natl Acad Sci U S A. 2004 August 17; 101(33): 12030–12035. Published online 2004 June 21. doi: 10.1073/pnas.0401932101.PMCID: PMC514429 Synthesis of (-)-longithorone A: Using organic synthesis to probe a proposed biosynthesis Carl A. Morales, Mark E. Layton, and Matthew D. Shair Proc Natl Acad Sci U S A. 2004 August 17; 101(33): 12036–12041. Published online 2004 June 9. doi: 10.1073/pnas.0401952101.PMCID: PMC514430 A unified approach to the tedanolides: Total synthesis of (+)-13-deoxytedanolide Amos B. Smith, III, Christopher M. Adams, Stephanie A. Lodise Barbosa, and Andrew P. Degnan Proc Natl Acad Sci U S A. 2004 August 17; 101(33): 12042–12047. Published online 2004 May 26. doi: 10.1073/pnas.0402084101.PMCID: PMC514431 An enantioselective, modular, and general route to the cytochalasins: Synthesis of L-696,474 and cytochalasin B Andrew M. Haidle and Andrew G. Myers Proc Natl Acad Sci U S A. 2004 August 17; 101(33): 12048–12053. Published online 2004 June 18. doi: 10.1073/pnas.0402111101.PMCID: PMC514432 Efficient construction of the securine A carbon skeleton Peter Korakas, Stuart Chaffee, J. Brad Shotwell, Pamela Duque, and John L. Wood Proc Natl Acad Sci U S A. 2004 August 17; 101(33): 12054–12057. Published online 2004 July 27. doi: 10.1073/pnas.0402274101.PMCID: PMC514433 Studies of stereocontrolled allylation reactions for the total synthesis of phorboxazole A David R. Williams, Andre A. Kiryanov, Ulrich Emde, Michael P. Clark, Martin A. Berliner, and Jonathan T. Reeves Proc Natl Acad Sci U S A. 2004 August 17; 101(33): 12058–12063. Published online 2004 July 26. doi: 10.1073/pnas.0402477101.PMCID: PMC514434 A nucleophile-catalyzed cycloisomerization permits a concise synthesis of (+)-harziphilone Lucy M. Stark, Klaus Pekari, and Erik J. Sorensen Proc Natl Acad Sci U S A. 2004 August 17; 101(33): 12064–12066. Published online 2004 July 1. doi: 10.1073/pnas.0402563101.PMCID: PMC514435 Total synthesis of the marine cyanobacterial cyclodepsipeptide apratoxin A Jiehao Chen and Craig J. Forsyth Proc Natl Acad Sci U S A. 2004 August 17; 101(33): 12067–12072. Published online 2004 July 1. doi: 10.1073/pnas.0402752101.PMCID: PMC514436 Synthesis of the thapsigargins Steven V. Ley, Alessandra Antonello, Emily P. Balskus, David T. Booth, Søren B. Christensen, Ed Cleator, Helen Gold, Klemens Högenauer, Udo Hünger, Rebecca M. Myers, Steven F. Oliver, Oliver Simic, Martin D. Smith, Helmer Søhoel, and Alison J. A. Woolford Proc Natl Acad Sci U S A. 2004 August 17; 101(33): 12073–12078. Published online 2004 June 28. doi: 10.1073/pnas.0403300101.PMCID: PMC514437 Total synthesis of (±)-halichlorine, (±)-pinnaic acid, and (±)-tauropinnaic acid Hamish S. Christie and Clayton H. Heathcock Proc Natl Acad Sci U S A. 2004 August 17; 101(33): 12079–12084. Published online 2004 August 6. doi: 10.1073/pnas.0403887101.PMCID: PMC514438 Energetic clues to pathways to biomineralization: Precursors, clusters, and nanoparticles Alexandra Navrotsky Proc Natl Acad Sci U S A. 2004 August 17; 101(33): 12096–12101. Published online 2004 August 5. doi: 10.1073/pnas.0404778101.PMCID: PMC514441 Computer Sciences msari: Multiple sequence alignments for statistical detection of RNA secondary structure Alex Coventry, Daniel J. Kleitman, and Bonnie Berger Proc Natl Acad Sci U S A. 2004 August 17; 101(33): 12102–12107. Published online 2004 August 10. doi: 10.1073/pnas.0404193101.PMCID: PMC514400 Physics Design for an optical cw atom laser Arthur Ashkin Proc Natl Acad Sci U S A. 2004 August 17; 101(33): 12108–12113. Published online 2004 August 9. doi: 10.1073/pnas.0404435101.PMCID: PMC514442 Statistics CisModule: De novo discovery of cis-regulatory modules by hierarchical mixture modeling Qing Zhou and Wing H. Wong Proc Natl Acad Sci U S A. 2004 August 17; 101(33): 12114–12119. Published online 2004 August 5. doi: 10.1073/pnas.0402858101.PMCID: PMC514443 Bayesian analysis of botanical epidemics using stochastic compartmental models G. J. Gibson, A. Kleczkowski, and C. A. Gilligan Proc Natl Acad Sci U S A. 2004 August 17; 101(33): 12120–12124. Published online 2004 August 9. doi: 10.1073/pnas.0400829101.PMCID: PMC514444 Biological Sciences Anthropology High-resolution vegetation and climate change associated with Pliocene Australopithecus afarensis R. Bonnefille, R. Potts, F. Chalié, D. Jolly, and O. Peyron Proc Natl Acad Sci U S A. 2004 August 17; 101(33): 12125–12129. Published online 2004 August 10. doi: 10.1073/pnas.0401709101.PMCID: PMC514445 Applied Biological Sciences Large-scale characterization of HeLa cell nuclear phosphoproteins Sean A. Beausoleil, Mark Jedrychowski, Daniel Schwartz, Joshua E. Elias, Judit Villén, Jiaxu Li, Martin A. Cohn, Lewis C. Cantley, and Steven P. Gygi Proc Natl Acad Sci U S A. 2004 August 17; 101(33): 12130–12135. Published online 2004 August 9. doi: 10.1073/pnas.0404720101.PMCID: PMC514446 Biochemistry SspB delivery of substrates for ClpXP proteolysis probed by the design of improved degradation tags Greg L. Hersch, Tania A. Baker, and Robert T. Sauer Proc Natl Acad Sci U S A. 2004 August 17; 101(33): 12136–12141. Published online 2004 August 5. doi: 10.1073/pnas.0404733101.PMCID: PMC514447 Structure of the photolyase-like domain of cryptochrome 1 from Arabidopsis thaliana Chad A. Brautigam, Barbara S. Smith, Zhiquan Ma, Maya Palnitkar, Diana R. Tomchick, Mischa Machius, and Johann Deisenhofer Proc Natl Acad Sci U S A. 2004 August 17; 101(33): 12142–12147. Published online 2004 August 6. doi: 10.1073/pnas.0404851101.PMCID: PMC514401 Binding affinity of lactose permease is not altered by the H+ electrochemical gradient Lan Guan and H. Ronald Kaback Proc Natl Acad Sci U S A. 2004 August 17; 101(33): 12148–12152. Published online 2004 August 10. doi: 10.1073/pnas.0404936101.PMCID: PMC514448 MED16 and MED23 of Mediator are coactivators of lipopolysaccharide- and heat-shock-induced transcriptional activators Tae Whan Kim, Yong-Jae Kwon, Jung Mo Kim, Young-Hwa Song, Se Nyun Kim, and Young-Joon Kim Proc Natl Acad Sci U S A. 2004 August 17; 101(33): 12153–12158. Published online 2004 August 5. doi: 10.1073/pnas.0401985101.PMCID: PMC514449 Thermophilic ATP synthase has a decamer c-ring: Indication of noninteger 10:3 H+/ATP ratio and permissive elastic coupling Noriyo Mitome, Toshiharu Suzuki, Shigehiko Hayashi, and Masasuke Yoshida Proc Natl Acad Sci U S A. 2004 August 17; 101(33): 12159–12164. Published online 2004 August 9. doi: 10.1073/pnas.0403545101.PMCID: PMC514450 YY1 inhibits the activation of the p53 tumor suppressor in response to genotoxic stress Eva Grönroos, Alexei A. Terentiev, Tanel Punga, and Johan Ericsson Proc Natl Acad Sci U S A. 2004 August 17; 101(33): 12165–12170. Published online 2004 August 4. doi: 10.1073/pnas.0402283101.PMCID: PMC514451 Detection of the mycophenolate-inhibited form of IMP dehydrogenase in vivo Christine C. McPhillips, Judith W. Hyle, and Daniel Reines Proc Natl Acad Sci U S A. 2004 August 17; 101(33): 12171–12176. Published online 2004 August 3. doi: 10.1073/pnas.0403341101.PMCID: PMC514452 Biophysics Nucleic acid transport through carbon nanotube membranes In-Chul Yeh and Gerhard Hummer Proc Natl Acad Sci U S A. 2004 August 17; 101(33): 12177–12182. Published online 2004 August 9. doi: 10.1073/pnas.0402699101.PMCID: PMC514453 X-ray structure analysis of a designed oligomeric miniprotein reveals a discrete quaternary architecture Mayssam H. Ali, Ezra Peisach, Karen N. Allen, and Barbara Imperiali Proc Natl Acad Sci U S A. 2004 August 17; 101(33): 12183–12188. Published online 2004 August 9. doi: 10.1073/pnas.0401245101.PMCID: PMC514454 Subdomain organization of the Acanthamoeba myosin IC tail from cryo-electron microscopy Takashi Ishikawa, Naiqian Cheng, Xiong Liu, Edward D. Korn, and Alasdair C. Steven Proc Natl Acad Sci U S A. 2004 August 17; 101(33): 12189–12194. Published online 2004 August 9. doi: 10.1073/pnas.0404835101.PMCID: PMC514455 Active hair-bundle motility harnesses noise to operate near an optimum of mechanosensitivity Björn Nadrowski, Pascal Martin, and Frank Jülicher Proc Natl Acad Sci U S A. 2004 August 17; 101(33): 12195–12200. Published online 2004 August 9. doi: 10.1073/pnas.0403020101.PMCID: PMC514456 From the Cover: Approximate protein structural alignment in polynomial time Rachel Kolodny and Nathan Linial Proc Natl Acad Sci U S A. 2004 August 17; 101(33): 12201–12206. Published online 2004 August 10. doi: 10.1073/pnas.0404383101.PMCID: PMC514457 Autocatalytic self-propagation of misfolded prion protein Jan Bieschke, Petra Weber, Nikolaus Sarafoff, Michael Beekes, Armin Giese, and Hans Kretzschmar Proc Natl Acad Sci U S A. 2004 August 17; 101(33): 12207–12211. Published online 2004 August 5. doi: 10.1073/pnas.0404650101.PMCID: PMC514458 Cell Biology A vascular cell-restricted RhoGAP, p73RhoGAP, is a key regulator of angiogenesis Zhi-Jian Su, Christopher N. Hahn, Gregory J. Goodall, Niamh M. Reck, Annabell F. Leske, Ann Davy, Gabriel Kremmidiotis, Mathew A. Vadas, and Jennifer R. Gamble Proc Natl Acad Sci U S A. 2004 August 17; 101(33): 12212–12217. Published online 2004 August 9. doi: 10.1073/pnas.0404631101.PMCID: PMC514459 Developmental Biology Neuregulin induces the expression of transcription factors and myosin heavy chains typical of muscle spindles in cultured human muscle Christian Jacobson, David Duggan, and Gerald Fischbach Proc Natl Acad Sci U S A. 2004 August 17; 101(33): 12218–12223. Published online 2004 August 9. doi: 10.1073/pnas.0404240101.PMCID: PMC514402 Ecology Bayesian analysis of botanical epidemics using stochastic compartmental models G. J. Gibson, A. Kleczkowski, and C. A. Gilligan Proc Natl Acad Sci U S A. 2004 August 17; 101(33): 12120–12124. Published online 2004 August 9. doi: 10.1073/pnas.0400829101.PMCID: PMC514444 Sexual selection explains Rensch's rule of size dimorphism in shorebirds Tamás Székely, Robert P. Freckleton, and John D. Reynolds Proc Natl Acad Sci U S A. 2004 August 17; 101(33): 12224–12227. Published online 2004 August 10. doi: 10.1073/pnas.0404503101.PMCID: PMC514460 A mechanism for slow release of biomagnified cyanobacterial neurotoxins and neurodegenerative disease in Guam Susan J. Murch, Paul Alan Cox, and Sandra Anne Banack Proc Natl Acad Sci U S A. 2004 August 17; 101(33): 12228–12231. Published online 2004 August 4. doi: 10.1073/pnas.0404926101.PMCID: PMC514403 Evolution Gene duplication and speciation in Drosophila: Evidence from the Odysseus locus Chau-Ti Ting, Shun-Chern Tsaur, Sha Sun, William E. Browne, Yung-Chia Chen, Nipam H. Patel, and Chung-I Wu Proc Natl Acad Sci U S A. 2004 August 17; 101(33): 12232–12235. Published online 2004 August 10. doi: 10.1073/pnas.0401975101.PMCID: PMC514461 Evolution of p53 in hypoxia-stressed Spalax mimics human tumor mutation Osnat Ashur-Fabian, Aaron Avivi, Luba Trakhtenbrot, Konstantin Adamsky, Meytal Cohen, Gadi Kajakaro, Alma Joel, Ninette Amariglio, Eviatar Nevo, and Gideon Rechavi Proc Natl Acad Sci U S A. 2004 August 17; 101(33): 12236–12241. Published online 2004 August 9. doi: 10.1073/pnas.0404998101.PMCID: PMC514462 Accelerated immunosenescence in preindustrial twin mothers Samuli Helle, Virpi Lummaa, and Jukka Jokela Proc Natl Acad Sci U S A. 2004 August 17; 101(33): 12391–12396. Published online 2004 August 4. doi: 10.1073/pnas.0402215101.PMCID: PMC514486 Genetics CisModule: De novo discovery of cis-regulatory modules by hierarchical mixture modeling Qing Zhou and Wing H. Wong Proc Natl Acad Sci U S A. 2004 August 17; 101(33): 12114–12119. Published online 2004 August 5. doi: 10.1073/pnas.0402858101.PMCID: PMC514443 K+ channel interactions detected by a genetic system optimized for systematic studies of membrane protein interactions Petr Obrdlik, Mohamed El-Bakkoury, Tanja Hamacher, Corinna Cappellaro, Cristina Vilarino, Carola Fleischer, Heinz Ellerbrok, Richard Kamuzinzi, Valérie Ledent, Damien Blaudez, Dale Sanders, Jose L. Revuelta, Eckhard Boles, Bruno André, and Wolf B. Frommer Proc Natl Acad Sci U S A. 2004 August 17; 101(33): 12242–12247. Published online 2004 August 6. doi: 10.1073/pnas.0404467101.PMCID: PMC514463 From the Cover: Highly efficient gene replacements in Neurospora strains deficient for nonhomologous end-joining Yuuko Ninomiya, Keiichiro Suzuki, Chizu Ishii, and Hirokazu Inoue Proc Natl Acad Sci U S A. 2004 August 17; 101(33): 12248–12253. Published online 2004 August 6. doi: 10.1073/pnas.0402780101.PMCID: PMC514464 Immunology The T cell antigen receptor expressed by Vα14i NKT cells has a unique mode of glycosphingolipid antigen recognition Stéphane Sidobre, Kirsten J. L. Hammond, Lise Bénazet-Sidobre, Sergei D. Maltsev, Stewart K. Richardson, Rachel M. Ndonye, Amy R. Howell, Teruyuki Sakai, Gurdyal S. Besra, Steven A. Porcelli, and Mitchell Kronenberg Proc Natl Acad Sci U S A. 2004 August 17; 101(33): 12254–12259. Published online 2004 August 10. doi: 10.1073/pnas.0404632101.PMCID: PMC514465 Essential role for virus-neutralizing antibodies in sterilizing immunity against Friend retrovirus infection Ronald J. Messer, Ulf Dittmer, Karin E. Peterson, and Kim J. Hasenkrug Proc Natl Acad Sci U S A. 2004 August 17; 101(33): 12260–12265. Published online 2004 August 5. doi: 10.1073/pnas.0404769101.PMCID: PMC514466 Medical Sciences From the Cover: Quantifiable cytotoxic T lymphocyte responses and HLA-related risk of progression to AIDS Almut Scherer, John Frater, Annette Oxenius, Juliet Agudelo, David A. Price, Huldrych F. Günthard, Martin Barnardo, Luc Perrin, Bernard Hirschel, Rodney E. Phillips, Angela R. McLean, and The Swiss HIV Cohort Study Proc Natl Acad Sci U S A. 2004 August 17; 101(33): 12266–12270. Published online 2004 August 9. doi: 10.1073/pnas.0404091101.PMCID: PMC514467 Prions can infect primary cultured neurons and astrocytes and promote neuronal cell death Sabrina Cronier, Hubert Laude, and Jean-Michel Peyrin Proc Natl Acad Sci U S A. 2004 August 17; 101(33): 12271–12276. Published online 2004 August 9. doi: 10.1073/pnas.0402725101.PMCID: PMC514468 Nitric oxide facilitates cardiomyogenesis in mouse embryonic stem cells Shinichi Kanno, Peter K. M. Kim, Karim Sallam, Jing Lei, Timothy R. Billiar, and Larry L. Shears, II Proc Natl Acad Sci U S A. 2004 August 17; 101(33): 12277–12281. Published online 2004 August 10. doi: 10.1073/pnas.0401557101.PMCID: PMC514469 Hypoxia-regulated therapeutic gene as a preemptive treatment strategy against ischemia/reperfusion tissue injury Alok S. Pachori, Luis G. Melo, Melanie L. Hart, Nicholas Noiseux, Lunan Zhang, Fulvio Morello, Scott D. Solomon, Gregory L. Stahl, Richard E. Pratt, and Victor J. Dzau Proc Natl Acad Sci U S A. 2004 August 17; 101(33): 12282–12287. Published online 2004 August 9. doi: 10.1073/pnas.0404616101.PMCID: PMC514470 Kinetics of regulated protein–protein interactions revealed with firefly luciferase complementation imaging in cells and living animals Kathryn E. Luker, Matthew C. P. Smith, Gary D. Luker, Seth T. Gammon, Helen Piwnica-Worms, and David Piwnica-Worms Proc Natl Acad Sci U S A. 2004 August 17; 101(33): 12288–12293. Published online 2004 July 29. doi: 10.1073/pnas.0404041101.PMCID: PMC514471 Visualization of antitumor treatment by means of fluorescence molecular tomography with an annexin V–Cy5.5 conjugate Vasilis Ntziachristos, Eyk A. Schellenberger, Jorge Ripoll, Doreen Yessayan, Edward Graves, Alexei Bogdanov, Jr., Lee Josephson, and Ralph Weissleder Proc Natl Acad Sci U S A. 2004 August 17; 101(33): 12294–12299. Published online 2004 August 10. doi: 10.1073/pnas.0401137101.PMCID: PMC514472 Chemical chaperones protect from effects of apoptosis-inducing mutation in carbonic anhydrase IV identified in retinitis pigmentosa 17 Giuseppe Bonapace, Abdul Waheed, Gul N. Shah, and William S. Sly Proc Natl Acad Sci U S A. 2004 August 17; 101(33): 12300–12305. Published online 2004 August 4. doi: 10.1073/pnas.0404764101.PMCID: PMC514473 Microbiology A eukaryotic BLUF domain mediates light-dependent gene expression in the purple bacterium Rhodobacter sphaeroides 2.4.1 Yuchen Han, Stephan Braatsch, Lisa Osterloh, and Gabriele Klug Proc Natl Acad Sci U S A. 2004 August 17; 101(33): 12306–12311. Published online 2004 August 3. doi: 10.1073/pnas.0403547101.PMCID: PMC514474 Staphylococcus aureus virulence genes identified by bursa aurealis mutagenesis and nematode killing Taeok Bae, Alison K. Banger, Adam Wallace, Elizabeth M. Glass, Fredrik Åslund, Olaf Schneewind, and Dominique M. Missiakas Proc Natl Acad Sci U S A. 2004 August 17; 101(33): 12312–12317. Published online 2004 August 10. doi: 10.1073/pnas.0404728101.PMCID: PMC514475 From the Cover: Listeria monocytogenes regulates flagellar motility gene expression through MogR, a transcriptional repressor required for virulence Angelika Gründling, Laura S. Burrack, H. G. Archie Bouwer, and Darren E. Higgins Proc Natl Acad Sci U S A. 2004 August 17; 101(33): 12318–12323. Published online 2004 August 9. doi: 10.1073/pnas.0404924101.PMCID: PMC514476 Highly pathogenic SHIVs and SIVs target different CD4+ T cell subsets in rhesus monkeys, explaining their divergent clinical courses Yoshiaki Nishimura, Tatsuhiko Igarashi, Olivia K. Donau, Alicia Buckler-White, Charles Buckler, Bernard A. P. Lafont, Robert M. Goeken, Simoy Goldstein, Vanessa M. Hirsch, and Malcolm A. Martin Proc Natl Acad Sci U S A. 2004 August 17; 101(33): 12324–12329. Published online 2004 August 5. doi: 10.1073/pnas.0404620101.PMCID: PMC514404 Translation arrest of SecM is essential for the basal and regulated expression of SecA Akiko Murakami, Hitoshi Nakatogawa, and Koreaki Ito Proc Natl Acad Sci U S A. 2004 August 17; 101(33): 12330–12335. Published online 2004 August 9. doi: 10.1073/pnas.0404907101.PMCID: PMC514405 Neuroscience DNA targeting of rhinal cortex D2 receptor protein reversibly blocks learning of cues that predict reward Zheng Liu, Barry J. Richmond, Elisabeth A. Murray, Richard C. Saunders, Sara Steenrod, Barbara K. Stubblefield, Deidra M. Montague, and Edward I. Ginns Proc Natl Acad Sci U S A. 2004 August 17; 101(33): 12336–12341. Published online 2004 August 9. doi: 10.1073/pnas.0403639101.PMCID: PMC514406 Gender-selective patterns of aggressive behavior in Drosophila melanogaster Steven P. Nilsen, Yick-Bun Chan, Robert Huber, and Edward A. Kravitz Proc Natl Acad Sci U S A. 2004 August 17; 101(33): 12342–12347. Published online 2004 August 9. doi: 10.1073/pnas.0404693101.PMCID: PMC514477 Goal-directed whisking increases phase-locking between vibrissa movement and electrical activity in primary sensory cortex in rat Karunesh Ganguly and David Kleinfeld Proc Natl Acad Sci U S A. 2004 August 17; 101(33): 12348–12353. Published online 2004 August 5. doi: 10.1073/pnas.0308470101.PMCID: PMC514478 The membrane actions of estrogens can potentiate their lordosis behavior-facilitating genomic actions Lee-Ming Kow and Donald W. Pfaff Proc Natl Acad Sci U S A. 2004 August 17; 101(33): 12354–12357. Published online 2004 August 9. doi: 10.1073/pnas.0404889101.PMCID: PMC514479 Sexual dichotomy of an interaction between early adversity and the serotonin transporter gene promoter variant in rhesus macaques Christina S. Barr, Timothy K. Newman, Melanie Schwandt, Courtney Shannon, Rachel L. Dvoskin, Stephen G. Lindell, Julie Taubman, Bill Thompson, Maribeth Champoux, Klaus Peter Lesch, David Goldman, Stephen J. Suomi, and J. Dee Higley Proc Natl Acad Sci U S A. 2004 August 17; 101(33): 12358–12363. Published online 2004 August 9. doi: 10.1073/pnas.0403763101.PMCID: PMC514480 Pharmacology Potent block of Cx36 and Cx50 gap junction channels by mefloquine Scott J. Cruikshank, Matthew Hopperstad, Meg Younger, Barry W. Connors, David C. Spray, and Miduturu Srinivas Proc Natl Acad Sci U S A. 2004 August 17; 101(33): 12364–12369. Published online 2004 August 5. doi: 10.1073/pnas.0402044101.PMCID: PMC514481 Physiology Tetrodotoxin-sensitive Na+ channels and muscarinic and purinergic receptors identified in human erythroid progenitor cells and red blood cell ghosts Joseph F. Hoffman, Alicia Dodson, Amittha Wickrema, and Sulayman D. Dib-Hajj Proc Natl Acad Sci U S A. 2004 August 17; 101(33): 12370–12374. Published online 2004 August 3. doi: 10.1073/pnas.0404228101.PMCID: PMC514482 Plant Biology A zeaxanthin-independent nonphotochemical quenching mechanism localized in the photosystem II core complex Giovanni Finazzi, Giles N. Johnson, Luca Dallosto, Pierre Joliot, Francis-André Wollman, and Roberto Bassi Proc Natl Acad Sci U S A. 2004 August 17; 101(33): 12375–12380. Published online 2004 August 10. doi: 10.1073/pnas.0404798101.PMCID: PMC514483 Auxin-induced SCFTIR1–Aux/IAA interaction involves stable modification of the SCFTIR1 complex Stefan Kepinski and Ottoline Leyser Proc Natl Acad Sci U S A. 2004 August 17; 101(33): 12381–12386. Published online 2004 August 4. doi: 10.1073/pnas.0402868101.PMCID: PMC514484 Population Biology A detailed picture of the origin of the Australian dingo, obtained from the study of mitochondrial DNA Peter Savolainen, Thomas Leitner, Alan N. Wilton, Elizabeth Matisoo-Smith, and Joakim Lundeberg Proc Natl Acad Sci U S A. 2004 August 17; 101(33): 12387–12390. Published online 2004 August 6. doi: 10.1073/pnas.0401814101.PMCID: PMC514485 Social Sciences Social Sciences INAUGURAL ARTICLE by a Recently Elected Academy Member: Biography of Alejandro Portes Liza Q. Bundesen Proc Natl Acad Sci U S A. 2004 August 17; 101(33): 11917–11919. Published online 2004 August 10. doi: 10.1073/pnas.0405169101.PMCID: PMC514408 INAUGURAL ARTICLE by a Recently Elected Academy Member: The schooling of children of immigrants: Contextual effects on the educational attainment of the second generation Alejandro Portes and Lingxin Hao Proc Natl Acad Sci U S A. 2004 August 17; 101(33): 11920–11927. Published online 2004 July 2. doi: 10.1073/pnas.0403418101.PMCID: PMC514409 Accelerated immunosenescence in preindustrial twin mothers Samuli Helle, Virpi Lummaa, and Jukka Jokela Proc Natl Acad Sci U S A. 2004 August 17; 101(33): 12391–12396. Published online 2004 August 4. doi: 10.1073/pnas.0402215101.PMCID: PMC514486 Correction Proc Natl Acad Sci U S A. 2004 August 17; 101(33): 12397–12398. doi: 10.1073/pnas.0404478101.PMCID: PMC514487 Corrects: Annette Sievers, et al. From the Cover: The ribosome as an entropy trap. Proc Natl Acad Sci U S A. 2004 May 25; 101(21): 7897–7901. |