| | This journal provides immediate access to some articles. Chemical Ecology Special Feature Introductory Perspective Chemical ecology in retrospect and prospect Jerrold Meinwald and Thomas Eisner Proc Natl Acad Sci U S A. 2008 March 25; 105(12): 4539–4540. doi: 10.1073/pnas.0800649105.PMCID: PMC2290750 Research Articles The lost origin of chemical ecology in the late 19th century Thomas Hartmann Proc Natl Acad Sci U S A. 2008 March 25; 105(12): 4541–4546. doi: 10.1073/pnas.0709231105.PMCID: PMC2290813 Selection for chemical trait remixing in an invasive weed after reassociation with a coevolved specialist A. R. Zangerl, M. C. Stanley, and M. R. Berenbaum Proc Natl Acad Sci U S A. 2008 March 25; 105(12): 4547–4552. doi: 10.1073/pnas.0710280105.PMCID: PMC2290761 cis-Jasmone induces Arabidopsis genes that affect the chemical ecology of multitrophic interactions with aphids and their parasitoids Toby J. A. Bruce, Michaela C. Matthes, Keith Chamberlain, Christine M. Woodcock, Abdul Mohib, Ben Webster, Lesley E. Smart, Michael A. Birkett, John A. Pickett, and Johnathan A. Napier Proc Natl Acad Sci U S A. 2008 March 25; 105(12): 4553–4558. doi: 10.1073/pnas.0710305105.PMCID: PMC2290791 Herbivory-induced changes in the small-RNA transcriptome and phytohormone signaling in Nicotiana attenuata Shree P. Pandey, Priyanka Shahi, Klaus Gase, and Ian T. Baldwin Proc Natl Acad Sci U S A. 2008 March 25; 105(12): 4559–4564. doi: 10.1073/pnas.0711363105.PMCID: PMC2290812 Context- and scale-dependent effects of floral CO2 on nectar foraging by Manduca sexta Joaquín Goyret, Poppy M. Markwell, and Robert A. Raguso Proc Natl Acad Sci U S A. 2008 March 25; 105(12): 4565–4570. doi: 10.1073/pnas.0708629105.PMCID: PMC2290757 Seed odor mediates an obligate ant–plant mutualism in Amazonian rainforests Elsa Youngsteadt, Satoshi Nojima, Christopher Häberlein, Stefan Schulz, and Coby Schal Proc Natl Acad Sci U S A. 2008 March 25; 105(12): 4571–4575. doi: 10.1073/pnas.0708643105.PMCID: PMC2290770 From the Cover: Chemical Ecology Special Feature: Evidence for olfactory search in wandering albatross, Diomedea exulans Gabrielle A. Nevitt, Marcel Losekoot, and Henri Weimerskirch Proc Natl Acad Sci U S A. 2008 March 25; 105(12): 4576–4581. doi: 10.1073/pnas.0709047105.PMCID: PMC2290754 Factors promoting marine invasions: A chemoecological approach Ernesto Mollo, Margherita Gavagnin, Marianna Carbone, Francesco Castelluccio, Ferdinando Pozone, Vassilios Roussis, José Templado, Michael T. Ghiselin, and Guido Cimino Proc Natl Acad Sci U S A. 2008 March 25; 105(12): 4582–4586. doi: 10.1073/pnas.0709355105.PMCID: PMC2290762 Evolution of polyketide synthases in bacteria Christian P. Ridley, Ho Young Lee, and Chaitan Khosla Proc Natl Acad Sci U S A. 2008 March 25; 105(12): 4595–4600. doi: 10.1073/pnas.0710107105.PMCID: PMC2290765 Perspective Biosynthetic origin of natural products isolated from marine microorganism–invertebrate assemblages T. Luke Simmons, R. Cameron Coates, Benjamin R. Clark, Niclas Engene, David Gonzalez, Eduardo Esquenazi, Pieter C. Dorrestein, and William H. Gerwick Proc Natl Acad Sci U S A. 2008 March 25; 105(12): 4587–4594. doi: 10.1073/pnas.0709851105.PMCID: PMC2290810 The evolution of gene collectives: How natural selection drives chemical innovation Michael A. Fischbach, Christopher T. Walsh, and Jon Clardy Proc Natl Acad Sci U S A. 2008 March 25; 105(12): 4601–4608. doi: 10.1073/pnas.0709132105.PMCID: PMC2290807 Letter Reply to Pape et al.: The phylogeography of HIV-1 group M subtype B Michael Worobey, Arthur E. Pitchenik, M. Thomas P. Gilbert, Gabriela Wlasiuk, and Andrew Rambaut Proc Natl Acad Sci U S A. 2008 March 25; 105(12): E16. doi: 10.1073/pnas.0712128105.PMCID: PMC2290816 This Week in PNAS Proc Natl Acad Sci U S A. 2008 March 25; 105(12): 4531–4532. doi: 10.1073/iti1208105.PMCID: PMC2290819 Commentaries Local knowledge helps determine protein structures Michael R. Gryk and Jeffrey C. Hoch Proc Natl Acad Sci U S A. 2008 March 25; 105(12): 4533–4534. doi: 10.1073/pnas.0801069105.PMCID: PMC2290792 The continuing evolution of a bacterial pathogen James B. Kaper and Mohamed A. Karmali Proc Natl Acad Sci U S A. 2008 March 25; 105(12): 4535–4536. doi: 10.1073/pnas.0801435105.PMCID: PMC2290787 SYMRK, an enigmatic receptor guarding and guiding microbial endosymbioses with plant roots Marcelle Holsters Proc Natl Acad Sci U S A. 2008 March 25; 105(12): 4537–4538. doi: 10.1073/pnas.0801270105.PMCID: PMC2290752 Physical Sciences Applied Physical Sciences Tug-of-war as a cooperative mechanism for bidirectional cargo transport by molecular motors Melanie J. I. Müller, Stefan Klumpp, and Reinhard Lipowsky Proc Natl Acad Sci U S A. 2008 March 25; 105(12): 4609–4614. doi: 10.1073/pnas.0706825105.PMCID: PMC2290779 Chemistry Factors promoting marine invasions: A chemoecological approach Ernesto Mollo, Margherita Gavagnin, Marianna Carbone, Francesco Castelluccio, Ferdinando Pozone, Vassilios Roussis, José Templado, Michael T. Ghiselin, and Guido Cimino Proc Natl Acad Sci U S A. 2008 March 25; 105(12): 4582–4586. doi: 10.1073/pnas.0709355105.PMCID: PMC2290762 A two-step nucleotide-flipping mechanism enables kinetic discrimination of DNA lesions by AGT Jie Hu, Ao Ma, and Aaron R. Dinner Proc Natl Acad Sci U S A. 2008 March 25; 105(12): 4615–4620. doi: 10.1073/pnas.0708058105.PMCID: PMC2290773 Dipole tensor-based atomic-resolution structure determination of a nanocrystalline protein by solid-state NMR W. Trent Franks, Benjamin J. Wylie, Heather L. Frericks Schmidt, Andrew J. Nieuwkoop, Rebecca-Maria Mayrhofer, Gautam J. Shah, Daniel T. Graesser, and Chad M. Rienstra Proc Natl Acad Sci U S A. 2008 March 25; 105(12): 4621–4626. doi: 10.1073/pnas.0712393105.PMCID: PMC2290771 Incremental parameter evaluation from incomplete data with application to the population pharmacology of anticoagulants Marcel O. Vlad, Alexandru Dan Corlan, Federico Morán, Peter Oefner, and John Ross Proc Natl Acad Sci U S A. 2008 March 25; 105(12): 4627–4632. doi: 10.1073/pnas.0711508105.PMCID: PMC2290818 Computer Sciences Tracing information flow on a global scale using Internet chain-letter data David Liben-Nowell and Jon Kleinberg Proc Natl Acad Sci U S A. 2008 March 25; 105(12): 4633–4638. doi: 10.1073/pnas.0708471105.PMCID: PMC2290760 Biological Sciences Anthropology Close correspondence between quantitative- and molecular-genetic divergence times for Neandertals and modern humans Timothy D. Weaver, Charles C. Roseman, and Chris B. Stringer Proc Natl Acad Sci U S A. 2008 March 25; 105(12): 4645–4649. doi: 10.1073/pnas.0709079105.PMCID: PMC2290803 The Homo floresiensis cranium (LB1): Size, scaling, and early Homo affinities Adam D. Gordon, Lisa Nevell, and Bernard Wood Proc Natl Acad Sci U S A. 2008 March 25; 105(12): 4650–4655. doi: 10.1073/pnas.0710041105.PMCID: PMC2290802 Applied Biological Sciences Immunization by a bacterial aerosol Lucila Garcia-Contreras, Yun-Ling Wong, Pavan Muttil, Danielle Padilla, Jerry Sadoff, Jessica DeRousse, Willem Andreas Germishuizen, Sunali Goonesekera, Katharina Elbert, Barry R. Bloom, Rich Miller, P. Bernard Fourie, Anthony Hickey, and David Edwards Proc Natl Acad Sci U S A. 2008 March 25; 105(12): 4656–4660. doi: 10.1073/pnas.0800043105.PMCID: PMC2290758 Biochemistry Molecular basis of thrombin recognition by protein C inhibitor revealed by the 1.6-Å structure of the heparin-bridged complex Wei Li, Ty E. Adams, Jyoti Nangalia, Charles T. Esmon, and James A. Huntington Proc Natl Acad Sci U S A. 2008 March 25; 105(12): 4661–4666. doi: 10.1073/pnas.0711055105.PMCID: PMC2290767 RNA-dependent lipid remodeling by bacterial multiple peptide resistance factors Hervé Roy and Michael Ibba Proc Natl Acad Sci U S A. 2008 March 25; 105(12): 4667–4672. doi: 10.1073/pnas.0800006105.PMCID: PMC2290796 The structure of LepA, the ribosomal back translocase Robin N. Evans, Gregor Blaha, Scott Bailey, and Thomas A. Steitz Proc Natl Acad Sci U S A. 2008 March 25; 105(12): 4673–4678. doi: 10.1073/pnas.0801308105.PMCID: PMC2290774 Biophysics Tug-of-war as a cooperative mechanism for bidirectional cargo transport by molecular motors Melanie J. I. Müller, Stefan Klumpp, and Reinhard Lipowsky Proc Natl Acad Sci U S A. 2008 March 25; 105(12): 4609–4614. doi: 10.1073/pnas.0706825105.PMCID: PMC2290779 A two-step nucleotide-flipping mechanism enables kinetic discrimination of DNA lesions by AGT Jie Hu, Ao Ma, and Aaron R. Dinner Proc Natl Acad Sci U S A. 2008 March 25; 105(12): 4615–4620. doi: 10.1073/pnas.0708058105.PMCID: PMC2290773 Dipole tensor-based atomic-resolution structure determination of a nanocrystalline protein by solid-state NMR W. Trent Franks, Benjamin J. Wylie, Heather L. Frericks Schmidt, Andrew J. Nieuwkoop, Rebecca-Maria Mayrhofer, Gautam J. Shah, Daniel T. Graesser, and Chad M. Rienstra Proc Natl Acad Sci U S A. 2008 March 25; 105(12): 4621–4626. doi: 10.1073/pnas.0712393105.PMCID: PMC2290771 Reassessing a sparse energetic network within a single protein domain Celestine N. Chi, Lisa Elfström, Yao Shi, Tord Snäll, Åke Engström, and Per Jemth Proc Natl Acad Sci U S A. 2008 March 25; 105(12): 4679–4684. doi: 10.1073/pnas.0711732105.PMCID: PMC2290805 From the Cover: Consistent blind protein structure generation from NMR chemical shift data Yang Shen, Oliver Lange, Frank Delaglio, Paolo Rossi, James M. Aramini, Gaohua Liu, Alexander Eletsky, Yibing Wu, Kiran K. Singarapu, Alexander Lemak, Alexandr Ignatchenko, Cheryl H. Arrowsmith, Thomas Szyperski, Gaetano T. Montelione, David Baker, and Ad Bax Proc Natl Acad Sci U S A. 2008 March 25; 105(12): 4685–4690. doi: 10.1073/pnas.0800256105.PMCID: PMC2290745 Myosin V and Kinesin act as tethers to enhance each others' processivity M. Yusuf Ali, Hailong Lu, Carol S. Bookwalter, David M. Warshaw, and Kathleen M. Trybus Proc Natl Acad Sci U S A. 2008 March 25; 105(12): 4691–4696. doi: 10.1073/pnas.0711531105.PMCID: PMC2290781 Unilamellar vesicle formation and encapsulation by microfluidic jetting Jeanne C. Stachowiak, David L. Richmond, Thomas H. Li, Allen P. Liu, Sapun H. Parekh, and Daniel A. Fletcher Proc Natl Acad Sci U S A. 2008 March 25; 105(12): 4697–4702. doi: 10.1073/pnas.0710875105.PMCID: PMC2290793 Monolayer purification: A rapid method for isolating protein complexes for single-particle electron microscopy Deborah F. Kelly, Danijela Dukovski, and Thomas Walz Proc Natl Acad Sci U S A. 2008 March 25; 105(12): 4703–4708. doi: 10.1073/pnas.0800867105.PMCID: PMC2290746 Cell Biology X-inactivation in female human embryonic stem cells is in a nonrandom pattern and prone to epigenetic alterations Yin Shen, Youko Matsuno, Shaun D. Fouse, Nagesh Rao, Sierra Root, Renhe Xu, Matteo Pellegrini, Arthur D. Riggs, and Guoping Fan Proc Natl Acad Sci U S A. 2008 March 25; 105(12): 4709–4714. doi: 10.1073/pnas.0712018105.PMCID: PMC2290804 Transposition of a reconstructed Harbinger element in human cells and functional homology with two transposon-derived cellular genes Ludivine Sinzelle, Vladimir V. Kapitonov, Dawid P. Grzela, Tobias Jursch, Jerzy Jurka, Zsuzsanna Izsvák, and Zoltán Ivics Proc Natl Acad Sci U S A. 2008 March 25; 105(12): 4715–4720. doi: 10.1073/pnas.0707746105.PMCID: PMC2290759 Gene expression-based screening identifies microtubule inhibitors as inducers of PGC-1α and oxidative phosphorylation Zoltan Arany, Bridget K. Wagner, Yanhong Ma, Jessica Chinsomboon, Dina Laznik, and Bruce M. Spiegelman Proc Natl Acad Sci U S A. 2008 March 25; 105(12): 4721–4726. doi: 10.1073/pnas.0800979105.PMCID: PMC2290788 Protein phosphatase 2A controls the activity of histone deacetylase 7 during T cell apoptosis and angiogenesis Maud Martin, Michael Potente, Veerle Janssens, Didier Vertommen, Jean-Claude Twizere, Mark H. Rider, Jozef Goris, Stefanie Dimmeler, Richard Kettmann, and Franck Dequiedt Proc Natl Acad Sci U S A. 2008 March 25; 105(12): 4727–4732. doi: 10.1073/pnas.0708455105.PMCID: PMC2290748 Splicing mediates the activity of four putative cellular internal ribosome entry sites Brian T. Baranick, Nathan A. Lemp, Jill Nagashima, Kei Hiraoka, Noriyuki Kasahara, and Christopher R. Logg Proc Natl Acad Sci U S A. 2008 March 25; 105(12): 4733–4738. doi: 10.1073/pnas.0710650105.PMCID: PMC2290820 Inositol trisphosphate 3-kinase B (InsP3KB) as a physiological modulator of myelopoiesis Yonghui Jia, Fabien Loison, Hidenori Hattori, Yitang Li, Christophe Erneux, Shin-Young Park, Chong Gao, Li Chai, Leslie E. Silberstein, Stephane Schurmans, and Hongbo R. Luo Proc Natl Acad Sci U S A. 2008 March 25; 105(12): 4739–4744. doi: 10.1073/pnas.0800218105.PMCID: PMC2290809 PHDs overactivation during chronic hypoxia “desensitizes” HIFα and protects cells from necrosis Amandine Ginouvès, Karine Ilc, Nuria Macías, Jacques Pouysségur, and Edurne Berra Proc Natl Acad Sci U S A. 2008 March 25; 105(12): 4745–4750. doi: 10.1073/pnas.0705680105.PMCID: PMC2290777 Heparan sulfate biosynthesis enzymes EXT1 and EXT2 affect NDST1 expression and heparan sulfate sulfation Jenny Presto, Maria Thuveson, Pernilla Carlsson, Marta Busse, Maria Wilén, Inger Eriksson, Marion Kusche-Gullberg, and Lena Kjellén Proc Natl Acad Sci U S A. 2008 March 25; 105(12): 4751–4756. doi: 10.1073/pnas.0705807105.PMCID: PMC2290785 ATP-dependent activation of p21WAF1/CIP1-associated Cdk2 by Cdc6 Qiuming Kan, Shigeki Jinno, Hanako Yamamoto, Kohei Kobayashi, and Hiroto Okayama Proc Natl Acad Sci U S A. 2008 March 25; 105(12): 4757–4762. doi: 10.1073/pnas.0706392105.PMCID: PMC2290776 Developmental Biology Zebrafish early cardiac connexin, Cx36.7/Ecx, regulates myofibril orientation and heart morphogenesis by establishing Nkx2.5 expression Naznin Sultana, Kakon Nag, Kazuyuki Hoshijima, Dale W. Laird, Atsushi Kawakami, and Shigehisa Hirose Proc Natl Acad Sci U S A. 2008 March 25; 105(12): 4763–4768. doi: 10.1073/pnas.0708451105.PMCID: PMC2290751 Ecology The lost origin of chemical ecology in the late 19th century Thomas Hartmann Proc Natl Acad Sci U S A. 2008 March 25; 105(12): 4541–4546. doi: 10.1073/pnas.0709231105.PMCID: PMC2290813 Herbivory-induced changes in the small-RNA transcriptome and phytohormone signaling in Nicotiana attenuata Shree P. Pandey, Priyanka Shahi, Klaus Gase, and Ian T. Baldwin Proc Natl Acad Sci U S A. 2008 March 25; 105(12): 4559–4564. doi: 10.1073/pnas.0711363105.PMCID: PMC2290812 Context- and scale-dependent effects of floral CO2 on nectar foraging by Manduca sexta Joaquín Goyret, Poppy M. Markwell, and Robert A. Raguso Proc Natl Acad Sci U S A. 2008 March 25; 105(12): 4565–4570. doi: 10.1073/pnas.0708629105.PMCID: PMC2290757 Seed odor mediates an obligate ant–plant mutualism in Amazonian rainforests Elsa Youngsteadt, Satoshi Nojima, Christopher Häberlein, Stefan Schulz, and Coby Schal Proc Natl Acad Sci U S A. 2008 March 25; 105(12): 4571–4575. doi: 10.1073/pnas.0708643105.PMCID: PMC2290770 From the Cover: Chemical Ecology Special Feature: Evidence for olfactory search in wandering albatross, Diomedea exulans Gabrielle A. Nevitt, Marcel Losekoot, and Henri Weimerskirch Proc Natl Acad Sci U S A. 2008 March 25; 105(12): 4576–4581. doi: 10.1073/pnas.0709047105.PMCID: PMC2290754 Factors promoting marine invasions: A chemoecological approach Ernesto Mollo, Margherita Gavagnin, Marianna Carbone, Francesco Castelluccio, Ferdinando Pozone, Vassilios Roussis, José Templado, Michael T. Ghiselin, and Guido Cimino Proc Natl Acad Sci U S A. 2008 March 25; 105(12): 4582–4586. doi: 10.1073/pnas.0709355105.PMCID: PMC2290762 Evolution of polyketide synthases in bacteria Christian P. Ridley, Ho Young Lee, and Chaitan Khosla Proc Natl Acad Sci U S A. 2008 March 25; 105(12): 4595–4600. doi: 10.1073/pnas.0710107105.PMCID: PMC2290765 Mapping H5N1 highly pathogenic avian influenza risk in Southeast Asia Marius Gilbert, Xiangming Xiao, Dirk U. Pfeiffer, M. Epprecht, Stephen Boles, Christina Czarnecki, Prasit Chaitaweesub, Wantanee Kalpravidh, Phan Q. Minh, M. J. Otte, Vincent Martin, and Jan Slingenbergh Proc Natl Acad Sci U S A. 2008 March 25; 105(12): 4769–4774. doi: 10.1073/pnas.0710581105.PMCID: PMC2290786 Environmental Sciences Photosynthetic maximum quantum yield increases are an essential component of the Southern Ocean phytoplankton response to iron Michael R. Hiscock, Veronica P. Lance, Amy M. Apprill, Robert R. Bidigare, Zackary I. Johnson, B. Greg Mitchell, Walker O. Smith, Jr., and Richard T. Barber Proc Natl Acad Sci U S A. 2008 March 25; 105(12): 4775–4780. doi: 10.1073/pnas.0705006105.PMCID: PMC2290768 Evolution Selection for chemical trait remixing in an invasive weed after reassociation with a coevolved specialist A. R. Zangerl, M. C. Stanley, and M. R. Berenbaum Proc Natl Acad Sci U S A. 2008 March 25; 105(12): 4547–4552. doi: 10.1073/pnas.0710280105.PMCID: PMC2290761 Evolution of malaria parasite plastid targeting sequences Christopher J. Tonkin, Bernardo J. Foth, Stuart A. Ralph, Nicole Struck, Alan F. Cowman, and Geoffrey I. McFadden Proc Natl Acad Sci U S A. 2008 March 25; 105(12): 4781–4785. doi: 10.1073/pnas.0707827105.PMCID: PMC2290815 Increasing morphological complexity in multiple parallel lineages of the Crustacea Sarah J. Adamowicz, Andy Purvis, and Matthew A. Wills Proc Natl Acad Sci U S A. 2008 March 25; 105(12): 4786–4791. doi: 10.1073/pnas.0709378105.PMCID: PMC2290764 Rapid large-scale evolutionary divergence in morphology and performance associated with exploitation of a different dietary resource Anthony Herrel, Katleen Huyghe, Bieke Vanhooydonck, Thierry Backeljau, Karin Breugelmans, Irena Grbac, Raoul Van Damme, and Duncan J. Irschick Proc Natl Acad Sci U S A. 2008 March 25; 105(12): 4792–4795. doi: 10.1073/pnas.0711998105.PMCID: PMC2290806 Immunology HDAC inhibitor reduces cytokine storm and facilitates induction of chimerism that reverses lupus in anti-CD3 conditioning regimen Nainong Li, Dongchang Zhao, Mark Kirschbaum, Chunyan Zhang, Chia-Lei Lin, Ivan Todorov, Fouad Kandeel, Stephen Forman, and Defu Zeng Proc Natl Acad Sci U S A. 2008 March 25; 105(12): 4796–4801. doi: 10.1073/pnas.0712051105.PMCID: PMC2290749 Maintenance of the plasma cell pool is independent of memory B cells Anupama Ahuja, Shannon M. Anderson, Ashraf Khalil, and Mark J. Shlomchik Proc Natl Acad Sci U S A. 2008 March 25; 105(12): 4802–4807. doi: 10.1073/pnas.0800555105.PMCID: PMC2290811 Role of the Akt pathway in mRNA translation of interferon-stimulated genes Surinder Kaur, Antonella Sassano, Blazej Dolniak, Sonali Joshi, Beata Majchrzak-Kita, Darren P. Baker, Nissim Hay, Eleanor N. Fish, and Leonidas C. Platanias Proc Natl Acad Sci U S A. 2008 March 25; 105(12): 4808–4813. doi: 10.1073/pnas.0710907105.PMCID: PMC2290753 Chemokine receptor CXCR3 and its ligands CXCL9 and CXCL10 are required for the development of murine cerebral malaria Gabriele S. V. Campanella, Andrew M. Tager, Joseph K. El Khoury, Seddon Y. Thomas, Tabitha A. Abrazinski, Lindsay A. Manice, Richard A. Colvin, and Andrew D. Luster Proc Natl Acad Sci U S A. 2008 March 25; 105(12): 4814–4819. doi: 10.1073/pnas.0801544105.PMCID: PMC2290783 Medical Sciences Incremental parameter evaluation from incomplete data with application to the population pharmacology of anticoagulants Marcel O. Vlad, Alexandru Dan Corlan, Federico Morán, Peter Oefner, and John Ross Proc Natl Acad Sci U S A. 2008 March 25; 105(12): 4627–4632. doi: 10.1073/pnas.0711508105.PMCID: PMC2290818 X-chromosome inactivation and epigenetic fluidity in human embryonic stem cells Susana S. Silva, Rebecca K. Rowntree, Shila Mekhoubad, and Jeannie T. Lee Proc Natl Acad Sci U S A. 2008 March 25; 105(12): 4820–4825. doi: 10.1073/pnas.0712136105.PMCID: PMC2290799 Dissection of mechanisms of Chinese medicinal formula Realgar-Indigo naturalis as an effective treatment for promyelocytic leukemia Lan Wang, Guang-Biao Zhou, Ping Liu, Jun-Hong Song, Yang Liang, Xiao-Jing Yan, Fang Xu, Bing-Shun Wang, Jian-Hua Mao, Zhi-Xiang Shen, Sai-Juan Chen, and Zhu Chen Proc Natl Acad Sci U S A. 2008 March 25; 105(12): 4826–4831. doi: 10.1073/pnas.0712365105.PMCID: PMC2290784 Decay dynamics of HIV-1 depend on the inhibited stages of the viral life cycle Ahmad R. Sedaghat, Jason B. Dinoso, Lin Shen, Claus O. Wilke, and Robert F. Siliciano Proc Natl Acad Sci U S A. 2008 March 25; 105(12): 4832–4837. doi: 10.1073/pnas.0711372105.PMCID: PMC2290747 Hedgehog signaling overrides p53-mediated tumor suppression by activating Mdm2 Yoshinori Abe, Eri Oda-Sato, Kei Tobiume, Keiko Kawauchi, Yoichi Taya, Koji Okamoto, Moshe Oren, and Nobuyuki Tanaka Proc Natl Acad Sci U S A. 2008 March 25; 105(12): 4838–4843. doi: 10.1073/pnas.0712216105.PMCID: PMC2290789 Cytosine methylation profiling of cancer cell lines Mathias Ehrich, Julia Turner, Peter Gibbs, Lara Lipton, Mara Giovanneti, Charles Cantor, and Dirk van den Boom Proc Natl Acad Sci U S A. 2008 March 25; 105(12): 4844–4849. doi: 10.1073/pnas.0712251105.PMCID: PMC2290817 Netrin-1 expression confers a selective advantage for tumor cell survival in metastatic breast cancer Julien Fitamant, Céline Guenebeaud, Marie-May Coissieux, Catherine Guix, Isabelle Treilleux, Jean-Yves Scoazec, Thomas Bachelot, Agnès Bernet, and Patrick Mehlen Proc Natl Acad Sci U S A. 2008 March 25; 105(12): 4850–4855. doi: 10.1073/pnas.0709810105.PMCID: PMC2290782 Linking Notch signaling to ischemic stroke Joseph F. Arboleda-Velasquez, Zhipeng Zhou, Hwa Kyoung Shin, Angeliki Louvi, Hyung-Hwan Kim, Sean I. Savitz, James K. Liao, Salvatore Salomone, Cenk Ayata, Michael A. Moskowitz, and Spyros Artavanis-Tsakonas Proc Natl Acad Sci U S A. 2008 March 25; 105(12): 4856–4861. doi: 10.1073/pnas.0709867105.PMCID: PMC2290794 Activation of Trk neurotrophin receptors by glucocorticoids provides a neuroprotective effect Freddy Jeanneteau, Michael J. Garabedian, and Moses V. Chao Proc Natl Acad Sci U S A. 2008 March 25; 105(12): 4862–4867. doi: 10.1073/pnas.0709102105.PMCID: PMC2290769 Microbiology From the Cover: Variation in virulence among clades of Escherichia coli O157:H7 associated with disease outbreaks Shannon D. Manning, Alifiya S. Motiwala, A. Cody Springman, Weihong Qi, David W. Lacher, Lindsey M. Ouellette, Janice M. Mladonicky, Patricia Somsel, James T. Rudrik, Stephen E. Dietrich, Wei Zhang, Bala Swaminathan, David Alland, and Thomas S. Whittam Proc Natl Acad Sci U S A. 2008 March 25; 105(12): 4868–4873. doi: 10.1073/pnas.0710834105.PMCID: PMC2290780 RXLR effector reservoir in two Phytophthora species is dominated by a single rapidly evolving superfamily with more than 700 members Rays H. Y. Jiang, Sucheta Tripathy, Francine Govers, and Brett M. Tyler Proc Natl Acad Sci U S A. 2008 March 25; 105(12): 4874–4879. doi: 10.1073/pnas.0709303105.PMCID: PMC2290801 Temperature-induced switch to the pathogenic yeast form of Histoplasma capsulatum requires Ryp1, a conserved transcriptional regulator Van Q. Nguyen and Anita Sil Proc Natl Acad Sci U S A. 2008 March 25; 105(12): 4880–4885. doi: 10.1073/pnas.0710448105.PMCID: PMC2290814 Rifamycin antibiotic resistance by ADP-ribosylation: Structure and diversity of Arr Jennifer Baysarowich, Kalinka Koteva, Donald W. Hughes, Linda Ejim, Emma Griffiths, Kun Zhang, Murray Junop, and Gerard D. Wright Proc Natl Acad Sci U S A. 2008 March 25; 105(12): 4886–4891. doi: 10.1073/pnas.0711939105.PMCID: PMC2290778 Neuroscience Ischemic preconditioning blocks BAD translocation, Bcl-xL cleavage, and large channel activity in mitochondria of postischemic hippocampal neurons Takahiro Miyawaki, Toshihiro Mashiko, Dimitry Ofengeim, Richard J. Flannery, Kyung-Min Noh, Sho Fujisawa, Laura Bonanni, Michael V. L. Bennett, R. Suzanne Zukin, and Elizabeth A. Jonas Proc Natl Acad Sci U S A. 2008 March 25; 105(12): 4892–4897. doi: 10.1073/pnas.0800628105.PMCID: PMC2290755 Light deprivation damages monoamine neurons and produces a depressive behavioral phenotype in rats M. M. C. Gonzalez and G. Aston-Jones Proc Natl Acad Sci U S A. 2008 March 25; 105(12): 4898–4903. doi: 10.1073/pnas.0703615105.PMCID: PMC2290795 Chemical transmission between dopaminergic neuron pairs Marie Vandecasteele, Jacques Glowinski, Jean-Michel Deniau, and Laurent Venance Proc Natl Acad Sci U S A. 2008 March 25; 105(12): 4904–4909. doi: 10.1073/pnas.0703121105.PMCID: PMC2290772 Motion vision is independent of color in Drosophila Satoko Yamaguchi, Reinhard Wolf, Claude Desplan, and Martin Heisenberg Proc Natl Acad Sci U S A. 2008 March 25; 105(12): 4910–4915. doi: 10.1073/pnas.0711484105.PMCID: PMC2290790 Loss of the inactive myotubularin-related phosphatase Mtmr13 leads to a Charcot–Marie–Tooth 4B2-like peripheral neuropathy in mice Fred L. Robinson, Ingrid R. Niesman, Kristina K. Beiswenger, and Jack E. Dixon Proc Natl Acad Sci U S A. 2008 March 25; 105(12): 4916–4921. doi: 10.1073/pnas.0800742105.PMCID: PMC2290800 Vesicle association and exocytosis at ribbon and extraribbon sites in retinal bipolar cell presynaptic terminals David Zenisek Proc Natl Acad Sci U S A. 2008 March 25; 105(12): 4922–4927. doi: 10.1073/pnas.0709067105.PMCID: PMC2290766 Plant Biology cis-Jasmone induces Arabidopsis genes that affect the chemical ecology of multitrophic interactions with aphids and their parasitoids Toby J. A. Bruce, Michaela C. Matthes, Keith Chamberlain, Christine M. Woodcock, Abdul Mohib, Ben Webster, Lesley E. Smart, Michael A. Birkett, John A. Pickett, and Johnathan A. Napier Proc Natl Acad Sci U S A. 2008 March 25; 105(12): 4553–4558. doi: 10.1073/pnas.0710305105.PMCID: PMC2290791 From the Cover: SymRK defines a common genetic basis for plant root endosymbioses with arbuscular mycorrhiza fungi, rhizobia, and Frankiabacteria Hassen Gherbi, Katharina Markmann, Sergio Svistoonoff, Joan Estevan, Daphné Autran, Gabor Giczey, Florence Auguy, Benjamin Péret, Laurent Laplaze, Claudine Franche, Martin Parniske, and Didier Bogusz Proc Natl Acad Sci U S A. 2008 March 25; 105(12): 4928–4932. doi: 10.1073/pnas.0710618105.PMCID: PMC2290763 Three thioredoxin targets in the inner envelope membrane of chloroplasts function in protein import and chlorophyll metabolism Sandra Bartsch, Julie Monnet, Kristina Selbach, Françoise Quigley, John Gray, Diter von Wettstein, Steffen Reinbothe, and Christiane Reinbothe Proc Natl Acad Sci U S A. 2008 March 25; 105(12): 4933–4938. doi: 10.1073/pnas.0800378105.PMCID: PMC2290756 Systems approach identifies an organic nitrogen-responsive gene network that is regulated by the master clock control gene CCA1 Rodrigo A. Gutiérrez, Trevor L. Stokes, Karen Thum, Xiaodong Xu, Mariana Obertello, Manpreet S. Katari, Milos Tanurdzic, Alexis Dean, Damion C. Nero, C. Robertson McClung, and Gloria M. Coruzzi Proc Natl Acad Sci U S A. 2008 March 25; 105(12): 4939–4944. doi: 10.1073/pnas.0800211105.PMCID: PMC2290744 Involvement of Arabidopsis HOS15 in histone deacetylation and cold tolerance Jianhua Zhu, Jae Cheol Jeong, Yanmei Zhu, Irina Sokolchik, Saori Miyazaki, Jian-Kang Zhu, Paul M. Hasegawa, Hans J. Bohnert, Huazhong Shi, Dae-Jin Yun, and Ray A. Bressan Proc Natl Acad Sci U S A. 2008 March 25; 105(12): 4945–4950. doi: 10.1073/pnas.0801029105.PMCID: PMC2290775 Genome-wide analysis for discovery of rice microRNAs reveals natural antisense microRNAs (nat-miRNAs) Cheng Lu, Dong-Hoon Jeong, Karthik Kulkarni, Manoj Pillay, Kan Nobuta, Rana German, Shawn R. Thatcher, Christopher Maher, Lifang Zhang, Doreen Ware, Bin Liu, Xiaofeng Cao, Blake C. Meyers, and Pamela J. Green Proc Natl Acad Sci U S A. 2008 March 25; 105(12): 4951–4956. doi: 10.1073/pnas.0708743105.PMCID: PMC2290808 Population Biology Population genomics of the wild yeast Saccharomyces paradoxus: Quantifying the life cycle Isheng J. Tsai, Douda Bensasson, Austin Burt, and Vassiliki Koufopanou Proc Natl Acad Sci U S A. 2008 March 25; 105(12): 4957–4962. doi: 10.1073/pnas.0707314105.PMCID: PMC2290798 Social Sciences Environmental Sciences Modeling targeted layered containment of an influenza pandemic in the United States M. Elizabeth Halloran, Neil M. Ferguson, Stephen Eubank, Ira M. Longini, Jr., Derek A. T. Cummings, Bryan Lewis, Shufu Xu, Christophe Fraser, Anil Vullikanti, Timothy C. Germann, Diane Wagener, Richard Beckman, Kai Kadau, Chris Barrett, Catherine A. Macken, Donald S. Burke, and Philip Cooley Proc Natl Acad Sci U S A. 2008 March 25; 105(12): 4639–4644. doi: 10.1073/pnas.0706849105.PMCID: PMC2290797 Social Sciences Tracing information flow on a global scale using Internet chain-letter data David Liben-Nowell and Jon Kleinberg Proc Natl Acad Sci U S A. 2008 March 25; 105(12): 4633–4638. doi: 10.1073/pnas.0708471105.PMCID: PMC2290760 |