| | This journal provides immediate access to some articles. Letter Going beyond the genetic view of cancer Razvan Tudor Radulescu PMCID: PMC2268604 This Week in PNAS Proc Natl Acad Sci U S A. 2008 February 26; 105(8): 2753–2754. doi: 10.1073/iti0808105.PMCID: PMC2268528 Editorial Charting the course for PNAS Randy Schekman PMCID: PMC2268529 Commentaries Ominous trends in nature recreation Peter Kareiva PMCID: PMC2268530 A folding space odyssey Alan R. Davidson PMCID: PMC2268531 DNA barcodes: Genes, genomics, and bioinformatics W. John Kress and David L. Erickson PMCID: PMC2268532 Profile Profile of Randy Schekman: Reflections on his first year as PNAS Editor-in-Chief Nick Zagorski PMCID: PMC2268533 Physical Sciences Applied Mathematics Dimer packings with gaps and electrostatics Mihai Ciucu PMCID: PMC2268534 Chemistry 6-Ethynylthieno[3,2-d]- and 6-ethynylthieno[2,3-d]pyrimidin-4-anilines as tunable covalent modifiers of ErbB kinases Edgar R. Wood, Lisa M. Shewchuk, Byron Ellis, Perry Brignola, Ronald L. Brashear, Thomas R. Caferro, Scott H. Dickerson, Hamilton D. Dickson, Kelly H. Donaldson, Michael Gaul, Robert J. Griffin, Anne M. Hassell, Barry Keith, Robert Mullin, Kimberly G. Petrov, Michael J. Reno, David W. Rusnak, Sarva M. Tadepalli, John C. Ulrich, Craig D. Wagner, Dana E. Vanderwall, Alex G. Waterson, Jon D. Williams, Wendy L. White, and David E. Uehling PMCID: PMC2268535 Synthesis and structural characterization of isolable phosphine coinage metal π-complexes Nathan D. Shapiro and F. Dean Toste PMCID: PMC2268536 p-Type semiconducting nickel oxide as an efficiency-enhancing anode interfacial layer in polymer bulk-heterojunction solar cells Michael D. Irwin, D. Bruce Buchholz, Alexander W. Hains, Robert P. H. Chang, and Tobin J. Marks PMCID: PMC2268537 Geology From the Cover:
Hydrogen and oxygen isotope ratios in human hair are related to geography James R. Ehleringer, Gabriel J. Bowen, Lesley A. Chesson, Adam G. West, David W. Podlesak, and Thure E. Cerling PMCID: PMC2268538 Biological Sciences Applied Biological Sciences Peptoids that mimic the structure, function, and mechanism of helical antimicrobial peptides Nathaniel P. Chongsiriwatana, James A. Patch, Ann M. Czyzewski, Michelle T. Dohm, Andrey Ivankin, David Gidalevitz, Ronald N. Zuckermann, and Annelise E. Barron PMCID: PMC2268539 Biochemistry 6-Ethynylthieno[3,2-d]- and 6-ethynylthieno[2,3-d]pyrimidin-4-anilines as tunable covalent modifiers of ErbB kinases Edgar R. Wood, Lisa M. Shewchuk, Byron Ellis, Perry Brignola, Ronald L. Brashear, Thomas R. Caferro, Scott H. Dickerson, Hamilton D. Dickson, Kelly H. Donaldson, Michael Gaul, Robert J. Griffin, Anne M. Hassell, Barry Keith, Robert Mullin, Kimberly G. Petrov, Michael J. Reno, David W. Rusnak, Sarva M. Tadepalli, John C. Ulrich, Craig D. Wagner, Dana E. Vanderwall, Alex G. Waterson, Jon D. Williams, Wendy L. White, and David E. Uehling PMCID: PMC2268535 From the Cover:
Quantitative biochemical rationale for differences in transmissibility of 1918 pandemic influenza A viruses Aravind Srinivasan, Karthik Viswanathan, Rahul Raman, Aarthi Chandrasekaran, S. Raguram, Terrence M. Tumpey, V. Sasisekharan, and Ram Sasisekharan PMCID: PMC2268540 Structure of a protein–DNA complex essential for DNA protection in spores of Bacillus species Ki Seog Lee, Daniela Bumbaca, Jeffrey Kosman, Peter Setlow, and Mark J. Jedrzejas PMCID: PMC2268541 Elevated globotriaosylsphingosine is a hallmark of Fabry disease Johannes M. Aerts, Johanna E. Groener, Sijmen Kuiper, Wilma E. Donker-Koopman, Anneke Strijland, Roelof Ottenhoff, Cindy van Roomen, Mina Mirzaian, Frits A. Wijburg, Gabor E. Linthorst, Anouk C. Vedder, Saskia M. Rombach, Josanne Cox-Brinkman, Pentti Somerharju, Rolf G. Boot, Carla E. Hollak, Roscoe O. Brady, and Ben J. Poorthuis PMCID: PMC2268542 A systems biology approach identifies the biochemical mechanisms regulating monoterpenoid essential oil composition in peppermint Rigoberto Rios-Estepa, Glenn W. Turner, James M. Lee, Rodney B. Croteau, and B. Markus Lange PMCID: PMC2268543 Collagen fibril architecture, domain organization, and triple-helical conformation govern its proteolysis Shiamalee Perumal, Olga Antipova, and Joseph P. R. O. Orgel PMCID: PMC2268544 Discovery of a lysophospholipid acyltransferase family essential for membrane asymmetry and diversity Daisuke Hishikawa, Hideo Shindou, Saori Kobayashi, Hiroki Nakanishi, Ryo Taguchi, and Takao Shimizu PMCID: PMC2268545 Biophysics CNK and HYP form a discrete dimer by their SAM domains to mediate RAF kinase signaling Thanashan Rajakulendran, Malha Sahmi, Igor Kurinov, Mike Tyers, Marc Therrien, and Frank Sicheri PMCID: PMC2268546 Peptide adsorption on a hydrophobic surface results from an interplay of solvation, surface, and intrapeptide forces D. Horinek, A. Serr, M. Geisler, T. Pirzer, U. Slotta, S. Q. Lud, J. A. Garrido, T. Scheibel, T. Hugel, and R. R. Netz PMCID: PMC2268547 Protein area occupancy at the center of the red blood cell membrane Allison D. Dupuy and Donald M. Engelman PMCID: PMC2268548 Cell Biology The stumpy gene is required for mammalian ciliogenesis Terrence Town, Joshua J. Breunig, Matthew R. Sarkisian, Charalampos Spilianakis, Albert E. Ayoub, Xiuxin Liu, Anthony F. Ferrandino, A. Rachel Gallagher, Ming O. Li, Pasko Rakic, and Richard A. Flavell PMCID: PMC2268549 Ca2+ oscillation frequency decoding in cardiac cell hypertrophy: Role of calcineurin/NFAT as Ca2+ signal integrators Matilde Colella, Francesca Grisan, Valerie Robert, Jay D. Turner, Andrew P. Thomas, and Tullio Pozzan PMCID: PMC2268550 Dysregulation of IL-32 in myelodysplastic syndrome and chronic myelomonocytic leukemia modulates apoptosis and impairs NK function A. Mario Marcondes, Andrew J. Mhyre, Derek L. Stirewalt, Soo-Hyun Kim, Charles A. Dinarello, and H. Joachim Deeg PMCID: PMC2268551 Single mutations convert an outward K+ channel into an inward K+ channel Legong Li, Kun Liu, Yong Hu, Dongping Li, and Sheng Luan PMCID: PMC2268552 Unfolded protein response and cell death after depletion of brefeldin A-inhibited guanine nucleotide-exchange protein GBF1 Carmen Citterio, Alessandro Vichi, Gustavo Pacheco-Rodriguez, Angel M. Aponte, Joel Moss, and Martha Vaughan PMCID: PMC2268553 Generation of human induced pluripotent stem cells from dermal fibroblasts W. E. Lowry, L. Richter, R. Yachechko, A. D. Pyle, J. Tchieu, R. Sridharan, A. T. Clark, and K. Plath PMCID: PMC2268554 miR-17-92 cluster accelerates adipocyte differentiation by negatively regulating tumor-suppressor Rb2/p130 Qiang Wang, Yan Chun Li, Jinhua Wang, Juan Kong, Yuchen Qi, Richard J. Quigg, and Xinmin Li PMCID: PMC2268555 Functional interactions among Orai1, TRPCs, and STIM1 suggest a STIM-regulated heteromeric Orai/TRPC model for SOCE/Icrac channels Yanhong Liao, Christian Erxleben, Joel Abramowitz, Veit Flockerzi, Michael Xi Zhu, David L. Armstrong, and Lutz Birnbaumer PMCID: PMC2268556 Developmental Biology Dual regulation by the Hunchback gradient in the Drosophila embryo Dmitri Papatsenko and Michael S. Levine PMCID: PMC2268557 SOX2-expressing progenitor cells generate all of the major cell types in the adult mouse pituitary gland Teddy Fauquier, Karine Rizzoti, Mehul Dattani, Robin Lovell-Badge, and Iain C. A. F. Robinson PMCID: PMC2268558 Retinoic acid deficiency alters second heart field formation Lucile Ryckebusch, Zengxin Wang, Nicolas Bertrand, Song-Chang Lin, Xuan Chi, Robert Schwartz, Stéphane Zaffran, and Karen Niederreither PMCID: PMC2268559 Ecology From the Cover:
Hydrogen and oxygen isotope ratios in human hair are related to geography James R. Ehleringer, Gabriel J. Bowen, Lesley A. Chesson, Adam G. West, David W. Podlesak, and Thure E. Cerling PMCID: PMC2268538 Rapid depletion of genotypes with fast growth and bold personality traits from harvested fish populations Peter A. Biro and John R. Post PMCID: PMC2268560 From the Cover:
DNA barcoding the floras of biodiversity hotspots Renaud Lahaye, Michelle van der Bank, Diego Bogarin, Jorge Warner, Franco Pupulin, Guillaume Gigot, Olivier Maurin, Sylvie Duthoit, Timothy G. Barraclough, and Vincent Savolainen PMCID: PMC2268561 Natal dispersal driven by environmental conditions interacting across the annual cycle of a migratory songbird Colin E. Studds, T. Kurt Kyser, and Peter P. Marra PMCID: PMC2268562 Evolution A systems approach to delineate functions of paralogous transcription factors: Role of the Yap family in the DNA damage response Kai Tan, Hoda Feizi, Colin Luo, Stephanie H. Fan, Timothy Ravasi, and Trey G. Ideker PMCID: PMC2268563 A test of the chromosomal theory of ecotypic speciation in Anopheles gambiae Nicholas C. Manoukis, Jeffrey R. Powell, Mahamoudou B. Touré, Adama Sacko, Frances E. Edillo, Mamadou B. Coulibaly, Sekou F. Traoré, Charles E. Taylor, and Nora J. Besansky PMCID: PMC2268564 MicroRNAs and the advent of vertebrate morphological complexity Alysha M. Heimberg, Lorenzo F. Sempere, Vanessa N. Moy, Philip C. J. Donoghue, and Kevin J. Peterson PMCID: PMC2268565 A giant frog with South American affinities from the Late Cretaceous of Madagascar Susan E. Evans, Marc E. H. Jones, and David W. Krause PMCID: PMC2268566 The Foldback-like element Galileo belongs to the P superfamily of DNA transposons and is widespread within the Drosophila genus Mar Marzo, Marta Puig, and Alfredo Ruiz PMCID: PMC2268567 Genetics HSP90 affects the expression of genetic variation and developmental stability in quantitative traits Todd A. Sangster, Neeraj Salathia, Soledad Undurraga, Ron Milo, Kurt Schellenberg, Susan Lindquist, and Christine Queitsch PMCID: PMC2268568 HSP90-buffered genetic variation is common in Arabidopsis thaliana Todd A. Sangster, Neeraj Salathia, Hana N. Lee, Etsuko Watanabe, Kurt Schellenberg, Keith Morneau, Hui Wang, Soledad Undurraga, Christine Queitsch, and Susan Lindquist PMCID: PMC2268569 HSP90/70 chaperones are required for rapid nucleosome removal upon induction of the GAL genes of yeast Monique Floer, Gene O. Bryant, and Mark Ptashne PMCID: PMC2268570 Immunology Epitope discovery in West Nile virus infection: Identification and immune recognition of viral epitopes Curtis P. McMurtrey, Alina Lelic, Paolo Piazza, Ayan K. Chakrabarti, Eric J. Yablonsky, Angela Wahl, Wilfried Bardet, Annette Eckerd, Robert L. Cook, Rachael Hess, Rico Buchli, Mark Loeb, Charles R. Rinaldo, Jonathan Bramson, and William H. Hildebrand PMCID: PMC2268571 Tpl2 and ERK transduce antiproliferative T cell receptor signals and inhibit transformation of chronically stimulated T cells Christos Tsatsanis, Katerina Vaporidi, Vassiliki Zacharioudaki, Ariadne Androulidaki, Yuri Sykulev, Andrew N. Margioris, and Philip N. Tsichlis PMCID: PMC2268572 PDC-TREM, a plasmacytoid dendritic cell-specific receptor, is responsible for augmented production of type I interferon Hiroshi Watarai, Etsuko Sekine, Sayo Inoue, Ryusuke Nakagawa, Tsuneyasu Kaisho, and Masaru Taniguchi PMCID: PMC2268573 CD4 T cells, lymphopenia, and IL-7 in a multistep pathway to autoimmunity Thomas Calzascia, Marc Pellegrini, Albert Lin, Kristine M. Garza, Alisha R. Elford, Arda Shahinian, Pamela S. Ohashi, and Tak W. Mak PMCID: PMC2268574 Immunologic and clinical effects of antibody blockade of cytotoxic T lymphocyte-associated antigen 4 in previously vaccinated cancer patients F. Stephen Hodi, Marcus Butler, Darryl A. Oble, Michael V. Seiden, Frank G. Haluska, Andrea Kruse, Suzanne MacRae, Marybeth Nelson, Christine Canning, Israel Lowy, Alan Korman, David Lautz, Sara Russell, Michael T. Jaklitsch, Nikhil Ramaiya, Teresa C. Chen, Donna Neuberg, James P. Allison, Martin C. Mihm, and Glenn Dranoff PMCID: PMC2268575 The PD-1/PD-L1 complex resembles the antigen-binding Fv domains of antibodies and T cell receptors David Yin-wei Lin, Yoshimasa Tanaka, Masashi Iwasaki, Apostolos G. Gittis, Hua-Poo Su, Bunzo Mikami, Taku Okazaki, Tasuku Honjo, Nagahiro Minato, and David N. Garboczi PMCID: PMC2268576 JNK MAP kinase activation is required for MTOC and granule polarization in NKG2D-mediated NK cell cytotoxicity Changlin Li, Baoxue Ge, Matthew Nicotra, Joel N. H. Stern, Hernan D. Kopcow, Xi Chen, and Jack L. Strominger PMCID: PMC2268577 NEMO recognition of ubiquitinated Bcl10 is required for T cell receptor-mediated NF-κB activation Chuan-Jin Wu and Jonathan D. Ashwell PMCID: PMC2268578 Selective suicide of cross-presenting CD8+ dendritic cells by cytochrome c injection shows functional heterogeneity within this subset Ming Lee Lin, Yifan Zhan, Anna I. Proietto, Sandro Prato, Li Wu, William R. Heath, Jose A. Villadangos, and Andrew M. Lew PMCID: PMC2268579 BH3-only protein Puma contributes to death of antigen-specific T cells during shutdown of an immune response to acute viral infection Silke F. Fischer, Gabrielle T. Belz, and Andreas Strasser PMCID: PMC2268580 Medical Sciences From the Cover:
Discovery of a selective inhibitor of oncogenic B-Raf kinase with potent antimelanoma activity James Tsai, John T. Lee, Weiru Wang, Jiazhong Zhang, Hanna Cho, Shumeye Mamo, Ryan Bremer, Sam Gillette, Jun Kong, Nikolas K. Haass, Katrin Sproesser, Ling Li, Keiran S. M. Smalley, Daniel Fong, Yong-Liang Zhu, Adhirai Marimuthu, Hoa Nguyen, Billy Lam, Jennifer Liu, Ivana Cheung, Julie Rice, Yoshihisa Suzuki, Catherine Luu, Calvin Settachatgul, Rafe Shellooe, John Cantwell, Sung-Hou Kim, Joseph Schlessinger, Kam Y. J. Zhang, Brian L. West, Ben Powell, Gaston Habets, Chao Zhang, Prabha N. Ibrahim, Peter Hirth, Dean R. Artis, Meenhard Herlyn, and Gideon Bollag PMCID: PMC2268581 Antisera induced by infusions of autologous Ad-CD154-leukemia B cells identify ROR1 as an oncofetal antigen and receptor for Wnt5a Tetsuya Fukuda, Liguang Chen, Tomoyuki Endo, Li Tang, Desheng Lu, Januario E. Castro, George F. Widhopf, II, Laura Z. Rassenti, Mark J. Cantwell, Charles E. Prussak, Dennis A. Carson, and Thomas J. Kipps PMCID: PMC2268582 HLA alleles determine differences in human natural killer cell responsiveness and potency Sungjin Kim, John B. Sunwoo, Liping Yang, Taewoong Choi, Yun-Jeong Song, Anthony R. French, Anna Vlahiotis, Jay F. Piccirillo, Marina Cella, Marco Colonna, Thalachallour Mohanakumar, Katharine C. Hsu, Bo Dupont, and Wayne M. Yokoyama PMCID: PMC2268583 Requirement of protein kinase D1 for pathological cardiac remodeling Jens Fielitz, Mi-Sung Kim, John M. Shelton, Xiaoxia Qi, Joseph A. Hill, James A. Richardson, Rhonda Bassel-Duby, and Eric N. Olson PMCID: PMC2268584 Microbiology Single gene reassortants identify a critical role for PB1, HA, and NA in the high virulence of the 1918 pandemic influenza virus Claudia Pappas, Patricia V. Aguilar, Christopher F. Basler, Alicia Solórzano, Hui Zeng, Lucy A. Perrone, Peter Palese, Adolfo García-Sastre, Jacqueline M. Katz, and Terrence M. Tumpey PMCID: PMC2268585 ESCRT factors restrict mycobacterial growth Jennifer A. Philips, Maura C. Porto, Hui Wang, Eric J. Rubin, and Norbert Perrimon PMCID: PMC2268586 Asymmetric segregation of protein aggregates is associated with cellular aging and rejuvenation Ariel B. Lindner, Richard Madden, Alice Demarez, Eric J. Stewart, and François Taddei PMCID: PMC2268587 Quorum size of Pseudomonas syringae is small and dictated by water availability on the leaf surface Glenn Dulla and Steven E. Lindow PMCID: PMC2268588 A virocidal amphipathic α-helical peptide that inhibits hepatitis C virus infection in vitro Guofeng Cheng, Ana Montero, Pablo Gastaminza, Christina Whitten-Bauer, Stefan F. Wieland, Masanori Isogawa, Brenda Fredericksen, Suganya Selvarajah, Philippe A. Gallay, M. Reza Ghadiri, and Francis V. Chisari PMCID: PMC2268589 Inhibition of proinflammatory and innate immune signaling pathways by a cytomegalovirus RIP1-interacting protein Claudia Mack, Albert Sickmann, David Lembo, and Wolfram Brune PMCID: PMC2268590 Dynamics of Pseudomonas aeruginosa genome evolution Kalai Mathee, Giri Narasimhan, Camilo Valdes, Xiaoyun Qiu, Jody M. Matewish, Michael Koehrsen, Antonis Rokas, Chandri N. Yandava, Reinhard Engels, Erliang Zeng, Raquel Olavarietta, Melissa Doud, Roger S. Smith, Philip Montgomery, Jared R. White, Paul A. Godfrey, Chinnappa Kodira, Bruce Birren, James E. Galagan, and Stephen Lory PMCID: PMC2268591 Neuroscience Regulation of excitability and plasticity by endocannabinoids and PKA in developing hippocampus Hiroki Yasuda, Yan Huang, and Tadaharu Tsumoto PMCID: PMC2268592 WAVE1 controls neuronal activity-induced mitochondrial distribution in dendritic spines Jee Young Sung, Olivia Engmann, Merilee A. Teylan, Angus C. Nairn, Paul Greengard, and Yong Kim PMCID: PMC2268593 Ultrasonic vocalization impairment of Foxp2 (R552H) knockin mice related to speech-language disorder and abnormality of Purkinje cells Eriko Fujita, Yuko Tanabe, Akira Shiota, Masatsugu Ueda, Kiyotaka Suwa, Mariko Y. Momoi, and Takashi Momoi PMCID: PMC2268594 Synapse elimination accompanies functional plasticity in hippocampal neurons Natalia Bastrikova, Gregory A. Gardner, Jeff M. Reece, Andreas Jeromin, and Serena M. Dudek PMCID: PMC2268595 Pharmacology Combinatorial augmentation of voltage-gated KCNQ potassium channels by chemical openers Qiaojie Xiong, Haiyan Sun, Yangming Zhang, Fajun Nan, and Min Li PMCID: PMC2268596 Physiology Acute regulation of aquaporin-2 phosphorylation at Ser-264 by vasopressin Robert A. Fenton, Hanne B. Moeller, Jason D. Hoffert, Ming-Jiun Yu, Søren Nielsen, and Mark A. Knepper PMCID: PMC2268597 Acid-sensing ion channels interact with and inhibit BK K+ channels Elena Yermolaieva Petroff, Margaret P. Price, Vladislav Snitsarev, Huiyu Gong, Victoria Korovkina, Francois M. Abboud, and Michael J. Welsh PMCID: PMC2268598 Plant Biology PolIVb influences RNA-directed DNA methylation independently of its role in siRNA biogenesis Rebecca A. Mosher, Frank Schwach, David Studholme, and David C. Baulcombe PMCID: PMC2268599 Arabidopsis LEAFY COTYLEDON2 induces maturation traits and auxin activity: Implications for somatic embryogenesis Sandra L. Stone, Siobhan A. Braybrook, Stephanie L. Paula, Linda W. Kwong, Jonathan Meuser, Julie Pelletier, Tzung-Fu Hsieh, Robert L. Fischer, Robert B. Goldberg, and John J. Harada PMCID: PMC2268600 Amino acid polymorphisms in Arabidopsis phytochrome B cause differential responses to light Daniele L. Filiault, Carolyn A. Wessinger, Jose R. Dinneny, Jason Lutes, Justin O. Borevitz, Detlef Weigel, Joanne Chory, and Julin N. Maloof PMCID: PMC2268601 From the Cover:
Allelic mutant series reveal distinct functions for Arabidopsis cycloartenol synthase 1 in cell viability and plastid biogenesis Elena Babiychuk, Pierrette Bouvier-Navé, Vincent Compagnon, Masashi Suzuki, Toshiya Muranaka, Marc Van Montagu, Sergei Kushnir, and Hubert Schaller PMCID: PMC2268602 Correction Correction for Lawrence et al., Land Change Science Special Feature: Ecological feedbacks following deforestation create the potential for a catastrophic ecosystem shift in tropical dry forest PMCID: PMC2268603 Corrects: Deborah Lawrence, et al. From The Cover:Land Change Science Special Feature:
Ecological feedbacks following deforestation create the potential for a catastrophic ecosystem shift in tropical dry forest. Proc Natl Acad Sci U S A. 2007 December 26; 104(52): 20696–20701. |
