| | This journal provides immediate access to some articles. Editorial Responsible authorship of papers in PNAS Nicholas R. Cozzarelli PMCID: PMC489963 Commentary From the Cover:
In defense of the cell: TRIM5α interception of mammalian retroviruses Kyeongeun Lee and Vineet N. KewalRamani PMCID: PMC489964 Physical Sciences Applied Physical Sciences From the Cover:
Chaotic microlasers based on dynamical localization Viktor A. Podolskiy, Evgenii Narimanov, Wei Fang, and Hui Cao PMCID: PMC489965 A rare-cell detector for cancer Robert T. Krivacic, Andras Ladanyi, Douglas N. Curry, H. B. Hsieh, Peter Kuhn, Danielle E. Bergsrud, Jane F. Kepros, Todd Barbera, Michael Y. Ho, Lan Bo Chen, Richard A. Lerner, and Richard H. Bruce PMCID: PMC489966 Chemistry Directed evolution of ligand dependence: Small-molecule-activated protein splicing Allen R. Buskirk, Yi-Ching Ong, Zev J. Gartner, and David R. Liu PMCID: PMC489967 Charge equilibration between two distinct sites in double helical DNA Sarah Delaney, Jae Yoo, Eric D. A. Stemp, and Jacqueline K. Barton PMCID: PMC489968 From the Cover:
Magnetic circular dichroism of peralkylated tetrasilane conformers Heather A. Fogarty, Roman Imhof, and Josef Michl PMCID: PMC489969 Computer Sciences MotifPrototyper: A Bayesian profile model for motif families Eric P. Xing and Richard M. Karp PMCID: PMC489970 Statistics Tree-structured supervised learning and the genetics of hypertension Jing Huang, Alfred Lin, Balasubramanian Narasimhan, Thomas Quertermous, C. Agnes Hsiung, Low-Tone Ho, John S. Grove, Michael Olivier, Koustubh Ranade, Neil J. Risch, and Richard A. Olshen PMCID: PMC489971 Biological Sciences Agricultural Sciences An alternative agriculture system is defined by a distinct expression profile of select gene transcripts and proteins Vinod Kumar, Douglas J. Mills, James D. Anderson, and Autar K. Mattoo PMCID: PMC489972 Anthropology Wild chimpanzee dentition and its implications for assessing life history in immature hominin fossils Adrienne Zihlman, Debra Bolter, and Christophe Boesch PMCID: PMC489973 Biochemistry Directed evolution of ligand dependence: Small-molecule-activated protein splicing Allen R. Buskirk, Yi-Ching Ong, Zev J. Gartner, and David R. Liu PMCID: PMC489967 Direct measurement of proton release by cytochrome c oxidase in solution during the F→O transition Dmitry Zaslavsky, Robert C. Sadoski, Sany Rajagukguk, Lois Geren, Francis Millett, Bill Durham, and Robert B. Gennis PMCID: PMC489974 Structure of HIV-1 reverse transcriptase bound to an inhibitor active against mutant reverse transcriptases resistant to other nonnucleoside inhibitors Janice D. Pata, William G. Stirtan, Steven W. Goldstein, and Thomas A. Steitz PMCID: PMC489975 Expanded dynamic range of fluorescent indicators for Ca2+ by circularly permuted yellow fluorescent proteins Takeharu Nagai, Shuichi Yamada, Takashi Tominaga, Michinori Ichikawa, and Atsushi Miyawaki PMCID: PMC490022 The Spn4 gene of Drosophila encodes a potent furin-directed secretory pathway serpin Martin J. Richer, Clairessa A. Keays, Jennifer Waterhouse, Jessey Minhas, Carl Hashimoto, and François Jean PMCID: PMC489976 The voltage-gated Na+ channel NaVBP has a role in motility, chemotaxis, and pH homeostasis of an alkaliphilic Bacillus Masahiro Ito, Haoxing Xu, Arthur A. Guffanti, Yi Wei, Lior Zvi, David E. Clapham, and Terry A. Krulwich PMCID: PMC490023 Heterodimeric complexes of Hop2 and Mnd1 function with Dmc1 to promote meiotic homolog juxtaposition and strand assimilation Yi-Kai Chen, Chih-Hsiang Leng, Heidi Olivares, Ming-Hui Lee, Yuan-Chih Chang, Wen-Mei Kung, Shih-Chieh Ti, Yu-Hui Lo, Andrew H.-J. Wang, Chia-Seng Chang, Douglas K. Bishop, Yi-Ping Hsueh, and Ting-Fang Wang PMCID: PMC490024 Binding of platelet glycoprotein Ibα to von Willebrand factor domain A1 stimulates the cleavage of the adjacent domain A2 by ADAMTS13 Kenji Nishio, Patricia J. Anderson, X. Long Zheng, and J. Evan Sadler PMCID: PMC489977 Biophysics An amyloid-forming segment of β2-microglobulin suggests a molecular model for the fibril Magdalena I. Ivanova, Michael R. Sawaya, Mari Gingery, Antoine Attinger, and David Eisenberg PMCID: PMC489978 Cell Biology MotifPrototyper: A Bayesian profile model for motif families Eric P. Xing and Richard M. Karp PMCID: PMC489970 NFAT is a nerve activity sensor in skeletal muscle and controls activity-dependent myosin switching Karl J. A. McCullagh, Elisa Calabria, Giorgia Pallafacchina, Stefano Ciciliot, Antonio L. Serrano, Carla Argentini, John M. Kalhovde, Terje Lømo, and Stefano Schiaffino PMCID: PMC489979 The Arabidopsis AtRAD51 gene is dispensable for vegetative development but required for meiosis Wuxing Li, Changbin Chen, Ullrich Markmann-Mulisch, Ljudmilla Timofejeva, Elmon Schmelzer, Hong Ma, and Bernd Reiss PMCID: PMC489980 Requirement of matrix metalloproteinase-9 for the transformation of human mammary epithelial cells by Stat3-C Tobias N. Dechow, Laura Pedranzini, Andrea Leitch, Kenneth Leslie, William L. Gerald, Irina Linkov, and Jacqueline F. Bromberg PMCID: PMC489981 Met provides essential signals for liver regeneration Malgorzata Borowiak, Alistair N. Garratt, Torsten Wüstefeld, Michael Strehle, Christian Trautwein, and Carmen Birchmeier PMCID: PMC490025 Drs2p-coupled aminophospholipid translocase activity in yeast Golgi membranes and relationship to in vivo function Paramasivam Natarajan, Jiyi Wang, Zhaolin Hua, and Todd R. Graham PMCID: PMC489982 Developmental Biology Abnormal sperm in mice with targeted deletion of the act (activator of cAMP-responsive element modulator in testis) gene Noora Kotaja, Dario De Cesare, Betina Macho, Lucia Monaco, Stefano Brancorsini, Ellen Goossens, Herman Tournaye, Anne Gansmuller, and Paolo Sassone-Corsi PMCID: PMC489983 From the Cover:
Target of rapamycin-mediated amino acid signaling in mosquito anautogeny Immo A. Hansen, Geoffrey M. Attardo, Jong-Hwa Park, Quan Peng, and Alexander S. Raikhel PMCID: PMC489984 Ecology Snow conditions may create an invisible barrier for lynx Nils Chr. Stenseth, Amir Shabbar, Kung-Sik Chan, Stan Boutin, Eli Knispel Rueness, Dorothee Ehrich, James W. Hurrell, Ole Chr. Lingjærde, and Kjetill S. Jakobsen PMCID: PMC489985 Evolution Evolutionary dynamics of tumor suppressor gene inactivation Martin A. Nowak, Franziska Michor, Natalia L. Komarova, and Yoh Iwasa PMCID: PMC489986 The mitochondrial genome of Paraspadella gotoi is highly reduced and reveals that chaetognaths are a sister group to protostomes Kevin G. Helfenbein, H. Matthew Fourcade, Rohit G. Vanjani, and Jeffrey L. Boore PMCID: PMC489987 Protozoan predation, diversifying selection, and the evolution of antigenic diversity in Salmonella Hans Wildschutte, David M. Wolfe, Aletheia Tamewitz, and Jeffrey G. Lawrence PMCID: PMC489988 Primate jumping genes elucidate strepsirrhine phylogeny Christian Roos, Jürgen Schmitz, and Hans Zischler PMCID: PMC489989 Genetics Bipolar orientation of chromosomes in Saccharomyces cerevisiae is monitored by Mad1 and Mad2, but not by Mad3 Marina S. Lee and Forrest A. Spencer PMCID: PMC489990 Somatolactin selectively regulates proliferation and morphogenesis of neural-crest derived pigment cells in medaka Shoji Fukamachi, Masazumi Sugimoto, Hiroshi Mitani, and Akihiro Shima PMCID: PMC489991 Pattern of polymorphism after strong artificial selection in a domestication event Hideki Innan and Yuseob Kim PMCID: PMC489992 Immunology NFAT5/TonEBP mutant mice define osmotic stress as a critical feature of the lymphoid microenvironment William Y. Go, Xuebin Liu, Michelle A. Roti, Forrest Liu, and Steffan N. Ho PMCID: PMC489993 Lack of Toll-like receptor 4 or myeloid differentiation factor 88 reduces atherosclerosis and alters plaque phenotype in mice deficient in apolipoprotein E Kathrin S. Michelsen, Michelle H. Wong, Prediman K. Shah, Wenxuan Zhang, Juliana Yano, Terence M. Doherty, Shizuo Akira, Tripathi B. Rajavashisth, and Moshe Arditi PMCID: PMC489994 Mycobacterial phosphatidylinositol mannoside is a natural antigen for CD1d-restricted T cells Karsten Fischer, Emmanuel Scotet, Marcus Niemeyer, Heidrun Koebernick, Jens Zerrahn, Sophie Maillet, Robert Hurwitz, Mischo Kursar, Marc Bonneville, Stefan H. E. Kaufmann, and Ulrich E. Schaible PMCID: PMC489995 PD-L1-deficient mice show that PD-L1 on T cells, antigen-presenting cells, and host tissues negatively regulates T cells Yvette E. Latchman, Spencer C. Liang, Yin Wu, Tatyana Chernova, Raymond A. Sobel, Martina Klemm, Vijay K. Kuchroo, Gordon J. Freeman, and Arlene H. Sharpe PMCID: PMC489996 Recombinant NY-ESO-1 protein with ISCOMATRIX adjuvant induces broad integrated antibody and CD4+ and CD8+ T cell responses in humans Ian D. Davis, Weisan Chen, Heather Jackson, Phillip Parente, Mark Shackleton, Wendie Hopkins, Qiyuan Chen, Nektaria Dimopoulos, Tina Luke, Roger Murphy, Andrew M. Scott, Eugene Maraskovsky, Grant McArthur, Duncan MacGregor, Sue Sturrock, Tsin Yee Tai, Simon Green, Andrew Cuthbertson, Darryl Maher, Lena Miloradovic, Susan V. Mitchell, Gerd Ritter, Achim A. Jungbluth, Yao-Tseng Chen, Sacha Gnjatic, Eric W. Hoffman, Lloyd J. Old, and Jonathan S. Cebon PMCID: PMC489997 Medical Sciences Selective disruption of PPARγ2 impairs the development of adipose tissue and insulin sensitivity Jifeng Zhang, Mingui Fu, Taixing Cui, Chen Xiong, Kefeng Xu, Wei Zhong, Yan Xiao, Donna Floyd, Jian Liang, En Li, Qing Song, and Yuqing E. Chen PMCID: PMC489998 The Treacher Collins syndrome (TCOF1) gene product is involved in ribosomal DNA gene transcription by interacting with upstream binding factor Benigno C. Valdez, Dale Henning, Rolando B. So, Jill Dixon, and Michael J. Dixon PMCID: PMC489999 Inhibition of fatty acid synthase (FAS) suppresses HER2/neu (erbB-2) oncogene overexpression in cancer cells Javier A. Menendez, Luciano Vellon, Inderjit Mehmi, Bharvi P. Oza, Santiago Ropero, Ramon Colomer, and Ruth Lupu PMCID: PMC490000 From the Cover:
Development of a cancer DNA phenotype prior to tumor formation Donald C. Malins, Katie M. Anderson, Naomi K. Gilman, Virginia M. Green, Edward A. Barker, and Karl Erik Hellström PMCID: PMC490001 Alzheimer's brains harbor somatic mtDNA control-region mutations that suppress mitochondrial transcription and replication Pinar E. Coskun, M. Flint Beal, and Douglas C. Wallace PMCID: PMC490002 Vasorin, a transforming growth factor β-binding protein expressed in vascular smooth muscle cells, modulates the arterial response to injury in vivo Yuichi Ikeda, Yasushi Imai, Hidetoshi Kumagai, Tetsuya Nosaka, Yoshihiro Morikawa, Tomoko Hisaoka, Ichiro Manabe, Koji Maemura, Takashi Nakaoka, Takeshi Imamura, Kohei Miyazono, Issei Komuro, Ryozo Nagai, and Toshio Kitamura PMCID: PMC490003 Ethanol toxicity in pancreatic acinar cells: Mediation by nonoxidative fatty acid metabolites David N. Criddle, Michael G. T. Raraty, John P. Neoptolemos, Alexei V. Tepikin, Ole H. Petersen, and Robert Sutton PMCID: PMC490004 Loss of locus coeruleus neurons and reduced startle in parkin null mice Rainer von Coelln, Bobby Thomas, Joseph M. Savitt, Kah Leong Lim, Masayuki Sasaki, Ellen J. Hess, Valina L. Dawson, and Ted M. Dawson PMCID: PMC490005 Absence of a reductase, NCB5OR, causes insulin-deficient diabetes Jianxin Xie, Hao Zhu, Kevin Larade, Annie Ladoux, Ayden Seguritan, Michelle Chu, Susumu Ito, Roderick T. Bronson, Edward H. Leiter, Chen-Yu Zhang, Evan D. Rosen, and H. Franklin Bunn PMCID: PMC490006 Mouse dyskerin mutations affect accumulation of telomerase RNA and small nucleolar RNA, telomerase activity, and ribosomal RNA processing Yuko Mochizuki, Jun He, Shashikant Kulkarni, Monica Bessler, and Philip J. Mason PMCID: PMC490007 MS analysis of single-nucleotide differences in circulating nucleic acids: Application to noninvasive prenatal diagnosis Chunming Ding, Rossa W. K. Chiu, Tze K. Lau, Tse N. Leung, Li C. Chan, Amy Y. Y. Chan, Pimlak Charoenkwan, Ivy S. L. Ng, Hai-yang Law, Edmond S. K. Ma, Xiangmin Xu, Chanane Wanapirak, Torpong Sanguansermsri, Can Liao, Mary Anne Tan Jin Ai, David H. K. Chui, Charles R. Cantor, and Y. M. Dennis Lo PMCID: PMC490008 A methionine aminopeptidase-2 inhibitor, PPI-2458, for the treatment of rheumatoid arthritis Sylvie G. Bernier, Douglas D. Lazarus, Edward Clark, Beth Doyle, Matthew T. Labenski, Charles D. Thompson, William F. Westlin, and Gerhard Hannig PMCID: PMC490009 Microbiology Retrovirus resistance factors Ref1 and Lv1 are species-specific variants of TRIM5α Theodora Hatziioannou, David Perez-Caballero, Annie Yang, Simone Cowan, and Paul D. Bieniasz PMCID: PMC490010 The human and African green monkey TRIM5α genes encode Ref1 and Lv1 retroviral restriction factor activities Zuzana Keckesova, Laura M. J. Ylinen, and Greg J. Towers PMCID: PMC490011 Trim5α protein restricts both HIV-1 and murine leukemia virus Melvyn W. Yap, Sébastien Nisole, Clare Lynch, and Jonathan P. Stoye PMCID: PMC490012 Varicella-zoster virus infection of human neural cells in vivo Armin Baiker, Klaus Fabel, Antonio Cozzio, Leigh Zerboni, Konstanze Fabel, Marvin Sommer, Nobuko Uchida, Dongping He, Irving Weissman, and Ann M. Arvin PMCID: PMC490013 Unique modifications with phosphocholine and phosphoethanolamine define alternate antigenic forms of Neisseria gonorrhoeae type IV pili Finn Terje Hegge, Paul G. Hitchen, Finn Erik Aas, Heidi Kristiansen, Cecilia Løvold, Wolfgang Egge-Jacobsen, Maria Panico, Weng Yee Leong, Victoria Bull, Mumtaz Virji, Howard R. Morris, Anne Dell, and Michael Koomey PMCID: PMC490014 Neuroscience O-GlcNAcylation regulates phosphorylation of tau: A mechanism involved in Alzheimer's disease Fei Liu, Khalid Iqbal, Inge Grundke-Iqbal, Gerald W. Hart, and Cheng-Xin Gong PMCID: PMC490015 Nitrosative stress linked to sporadic Parkinson's disease: S-nitrosylation of parkin regulates its E3 ubiquitin ligase activity Dongdong Yao, Zezong Gu, Tomohiro Nakamura, Zhong-Qing Shi, Yuliang Ma, Benjamin Gaston, Lisa A. Palmer, Edward M. Rockenstein, Zhuohua Zhang, Eliezer Masliah, Takashi Uehara, and Stuart A. Lipton PMCID: PMC490016 Emx2 homeodomain transcription factor interacts with eukaryotic translation initiation factor 4E (eIF4E) in the axons of olfactory sensory neurons Stéphane Nédélec, Isabelle Foucher, Isabelle Brunet, Colette Bouillot, Alain Prochiantz, and Alain Trembleau PMCID: PMC490017 Functional disassociation of the central and peripheral fatty acid amide signaling systems Benjamin F. Cravatt, Alan Saghatelian, Edward G. Hawkins, Angela B. Clement, Michael H. Bracey, and Aron H. Lichtman PMCID: PMC490018 Essential role of brain-derived neurotrophic factor in adult hippocampal function Lisa M. Monteggia, Michel Barrot, Craig M. Powell, Olivier Berton, Victor Galanis, Terry Gemelli, Sven Meuth, Andreas Nagy, Robert W. Greene, and Eric J. Nestler PMCID: PMC490019 RENKCTD11 is a suppressor of Hedgehog signaling and is deleted in human medulloblastoma Lucia Di Marcotullio, Elisabetta Ferretti, Enrico De Smaele, Beatrice Argenti, Claudia Mincione, Francesca Zazzeroni, Rita Gallo, Laura Masuelli, Maddalena Napolitano, Marella Maroder, Andrea Modesti, Felice Giangaspero, Isabella Screpanti, Edoardo Alesse, and Alberto Gulino PMCID: PMC490020 Population Biology The effects of host contact network structure on pathogen diversity and strain structure Caroline O'F. Buckee, Katia Koelle, Matthew J. Mustard, and Sunetra Gupta PMCID: PMC490021 |
