| | This journal provides immediate access to some articles. This Week in PNAS Proc Natl Acad Sci U S A. 2007 October 30; 104(44): 17241–17242. doi: 10.1073/iti4407104.PMCID: PMC2077236 Commentaries The tangled web of self-tying knots Andrew Belmonte PMCID: PMC2077237 PP2A as a mercenary for warring kinases in the egg Hongtao Yu PMCID: PMC2077238 Rites of passage through puberty: A complex genetic ensemble J. Larry Jameson PMCID: PMC2077239 Profiles Profile of Eugenia M. del Pino Kaspar Mossman PMCID: PMC2077240 Profile of Christian R. H. Raetz Nick Zagorski PMCID: PMC2077241 Physical Sciences Applied Physical Sciences Confocal light absorption and scattering spectroscopic microscopy monitors organelles in live cells with no exogenous labels Irving Itzkan, Le Qiu, Hui Fang, Munir M. Zaman, Edward Vitkin, Ionita C. Ghiran, Saira Salahuddin, Mark Modell, Charlotte Andersson, Lauren M. Kimerer, Patsy B. Cipolloni, Kee-Hak Lim, Steven D. Freedman, Irving Bigio, Benjamin P. Sachs, Eugene B. Hanlon, and Lev T. Perelman PMCID: PMC2077242 Switchable DNA interfaces for the highly sensitive detection of label-free DNA targets Ulrich Rant, Kenji Arinaga, Simon Scherer, Erika Pringsheim, Shozo Fujita, Naoki Yokoyama, Marc Tornow, and Gerhard Abstreiter PMCID: PMC2077262 Dynamic clustered distribution of hemagglutinin resolved at 40 nm in living cell membranes discriminates between raft theories Samuel T. Hess, Travis J. Gould, Manasa V. Gudheti, Sarah A. Maas, Kevin D. Mills, and Joshua Zimmerberg PMCID: PMC2077263 Chemistry Picosecond fluctuating protein energy landscape mapped by pressure–temperature molecular dynamics simulation Lars Meinhold, Jeremy C. Smith, Akio Kitao, and Ahmed H. Zewail PMCID: PMC2077243 Efficient production of [n]rotaxanes by using template-directed clipping reactions Jishan Wu, Ken Cham-Fai Leung, and J. Fraser Stoddart PMCID: PMC2077244 Chemical evolution: The mechanism of the formation of adenine under prebiotic conditions Debjani Roy, Katayoun Najafian, and Paul von Ragué Schleyer PMCID: PMC2077245 Engineering Analysis of nematode mechanics by piezoresistive displacement clamp Sung-Jin Park, Miriam B. Goodman, and Beth L. Pruitt PMCID: PMC2077264 Geology From the Cover:
Antarctic climate signature in the Greenland ice core record Stephen Barker and Gregor Knorr PMCID: PMC2077246 Physics Structural motifs of biomolecules Jayanth R. Banavar, Trinh Xuan Hoang, John H. Maddocks, Amos Maritan, Chiara Poletto, Andrzej Stasiak, and Antonio Trovato PMCID: PMC2077247 Nonstationary increments, scaling distributions, and variable diffusion processes in financial markets Kevin E. Bassler, Joseph L. McCauley, and Gemunu H. Gunaratne PMCID: PMC2077248 Optimal approach to quantum communication using dynamic programming Liang Jiang, Jacob M. Taylor, Navin Khaneja, and Mikhail D. Lukin PMCID: PMC2077249 Structure of sodium above 100 GPa by single-crystal x-ray diffraction M. I. McMahon, E. Gregoryanz, L. F. Lundegaard, I. Loa, C. Guillaume, R. J. Nelmes, A. K. Kleppe, M. Amboage, H. Wilhelm, and A. P. Jephcoat PMCID: PMC2077250 Mechanical control of the directional stepping dynamics of the kinesin motor Changbong Hyeon and José N. Onuchic PMCID: PMC2077265 Biological Sciences Applied Biological Sciences Engineered bidirectional communication mediates a consensus in a microbial biofilm consortium Katie Brenner, David K. Karig, Ron Weiss, and Frances H. Arnold PMCID: PMC2077251 Biochemistry ephrinB1 signals from the cell surface to the nucleus by recruitment of STAT3 Yong-Sik Bong, Hyun-Shik Lee, Laura Carim-Todd, Kathleen Mood, Tagvor G. Nishanian, Lino Tessarollo, and Ira O. Daar PMCID: PMC2077252 Crystal structure of human intrinsic factor: Cobalamin complex at 2.6-Å resolution F. S. Mathews, M. M. Gordon, Z. Chen, K. R. Rajashankar, S. E. Ealick, D. H. Alpers, and N. Sukumar PMCID: PMC2077253 GTPase acceleration as the rate-limiting step in Arabidopsis G protein-coupled sugar signaling Christopher A. Johnston, J. Philip Taylor, Yajun Gao, Adam J. Kimple, Jeffrey C. Grigston, Jin-Gui Chen, David P. Siderovski, Alan M. Jones, and Francis S. Willard PMCID: PMC2077254 Modulators of the structural dynamics of the retinoid X receptor to reveal receptor function Virginie Nahoum, Efrén Pérez, Pierre Germain, Fátima Rodríguez-Barrios, Fabio Manzo, Sabrina Kammerer, Geraldine Lemaire, Oliver Hirsch, Catherine A. Royer, Hinrich Gronemeyer, Angel R. de Lera, and William Bourguet PMCID: PMC2077255 Identifying the subproteome of kinetically stable proteins via diagonal 2D SDS/PAGE Ke Xia, Marta Manning, Helai Hesham, Qishan Lin, Christopher Bystroff, and Wilfredo Colón PMCID: PMC2077256 Unraveling the hidden catalytic activity of vertebrate class IIa histone deacetylases A. Lahm, C. Paolini, M. Pallaoro, M. C. Nardi, P. Jones, P. Neddermann, S. Sambucini, M. J. Bottomley, P. Lo Surdo, A. Carfí, U. Koch, R. De Francesco, C. Steinkühler, and P. Gallinari PMCID: PMC2077257 The prokaryotic Cys2His2 zinc-finger adopts a novel fold as revealed by the NMR structure of Agrobacterium tumefaciens Ros DNA-binding domain Gaetano Malgieri, Luigi Russo, Sabrina Esposito, Ilaria Baglivo, Laura Zaccaro, Emilia M. Pedone, Benedetto Di Blasio, Carla Isernia, Paolo V. Pedone, and Roberto Fattorusso PMCID: PMC2077258 Reevaluation of telomerase inhibition by quadruplex ligands and their mechanisms of action Anne De Cian, Gael Cristofari, Patrick Reichenbach, Elsa De Lemos, David Monchaud, Marie-Paule Teulade-Fichou, Kazuo Shin-ya, Laurent Lacroix, Joachim Lingner, and Jean-Louis Mergny PMCID: PMC2077259 Identification of functional paralog shift mutations: Conversion of Escherichia coli malate dehydrogenase to a lactate dehydrogenase Yifeng Yin and Jack F. Kirsch PMCID: PMC2077260 From the Cover:
Leptin activates hypothalamic acetyl-CoA carboxylase to inhibit food intake Su Gao, Kimberly P. Kinzig, Susan Aja, Karen A. Scott, Wendy Keung, Sandra Kelly, Ken Strynadka, Shigeru Chohnan, Wanli W. Smith, Kellie L. K. Tamashiro, Ellen E. Ladenheim, Gabriele V. Ronnett, Yajun Tu, Morris J. Birnbaum, Gary D. Lopaschuk, and Timothy H. Moran PMCID: PMC2077261 Biophysics Confocal light absorption and scattering spectroscopic microscopy monitors organelles in live cells with no exogenous labels Irving Itzkan, Le Qiu, Hui Fang, Munir M. Zaman, Edward Vitkin, Ionita C. Ghiran, Saira Salahuddin, Mark Modell, Charlotte Andersson, Lauren M. Kimerer, Patsy B. Cipolloni, Kee-Hak Lim, Steven D. Freedman, Irving Bigio, Benjamin P. Sachs, Eugene B. Hanlon, and Lev T. Perelman PMCID: PMC2077242 Picosecond fluctuating protein energy landscape mapped by pressure–temperature molecular dynamics simulation Lars Meinhold, Jeremy C. Smith, Akio Kitao, and Ahmed H. Zewail PMCID: PMC2077243 Structural motifs of biomolecules Jayanth R. Banavar, Trinh Xuan Hoang, John H. Maddocks, Amos Maritan, Chiara Poletto, Andrzej Stasiak, and Antonio Trovato PMCID: PMC2077247 Switchable DNA interfaces for the highly sensitive detection of label-free DNA targets Ulrich Rant, Kenji Arinaga, Simon Scherer, Erika Pringsheim, Shozo Fujita, Naoki Yokoyama, Marc Tornow, and Gerhard Abstreiter PMCID: PMC2077262 Dynamic clustered distribution of hemagglutinin resolved at 40 nm in living cell membranes discriminates between raft theories Samuel T. Hess, Travis J. Gould, Manasa V. Gudheti, Sarah A. Maas, Kevin D. Mills, and Joshua Zimmerberg PMCID: PMC2077263 Analysis of nematode mechanics by piezoresistive displacement clamp Sung-Jin Park, Miriam B. Goodman, and Beth L. Pruitt PMCID: PMC2077264 Mechanical control of the directional stepping dynamics of the kinesin motor Changbong Hyeon and José N. Onuchic PMCID: PMC2077265 Defined DNA sequences promote the assembly of a bacterial protein into distinct amyloid nanostructures Rafael Giraldo PMCID: PMC2077266 Molecular imaging of membrane interfaces reveals mode of β-glucosidase activation by saposin C Jean-René Alattia, James E. Shaw, Christopher M. Yip, and Gilbert G. Privé PMCID: PMC2077267 Probing polyproline structure and dynamics by photoinduced electron transfer provides evidence for deviations from a regular polyproline type II helix Sören Doose, Hannes Neuweiler, Hannes Barsch, and Markus Sauer PMCID: PMC2077268 Cell Biology High-resolution imaging of the dynamic tumor cell–vascular interface in transparent zebrafish Konstantin Stoletov, Valerie Montel, Robin D. Lester, Steven L. Gonias, and Richard Klemke PMCID: PMC2077269 An essential role for cortactin in the modulation of the potassium channel Kv1.2 Michael R. Williams, Jonathan C. Markey, Megan A. Doczi, and Anthony D. Morielli PMCID: PMC2077270 The SCFCdc4 ubiquitin ligase regulates calcineurin signaling through degradation of phosphorylated Rcn1, an inhibitor of calcineurin Tsutomu Kishi, Akemi Ikeda, Rina Nagao, and Noriko Koyama PMCID: PMC2077271 Human Gsα mutant causes pseudohypoparathyroidism type Ia/neonatal diarrhea, a potential cell-specific role of the palmitoylation cycle Noriko Makita, Junichiro Sato, Philippe Rondard, Hiroshi Fukamachi, Yasuhito Yuasa, Micheala A. Aldred, Makiko Hashimoto, Toshiro Fujita, and Taroh Iiri PMCID: PMC2077272 Ecology Drought mediates the importance of stochastic community assembly Jonathan M. Chase PMCID: PMC2077273 Evolution Gossip as an alternative for direct observation in games of indirect reciprocity Ralf D. Sommerfeld, Hans-Jürgen Krambeck, Dirk Semmann, and Manfred Milinski PMCID: PMC2077274 From the Cover:
Variation in HIV-1 set-point viral load: Epidemiological analysis and an evolutionary hypothesis Christophe Fraser, T. Déirdre Hollingsworth, Ruth Chapman, Frank de Wolf, and William P. Hanage PMCID: PMC2077275 Genetics From the Cover:
Loss-of-function mutation in the prokineticin 2 gene causes Kallmann syndrome and normosmic idiopathic hypogonadotropic hypogonadism Nelly Pitteloud, Chengkang Zhang, Duarte Pignatelli, Jia-Da Li, Taneli Raivio, Lindsay W. Cole, Lacey Plummer, Elka E. Jacobson-Dickman, Pamela L. Mellon, Qun-Yong Zhou, and William F. Crowley, Jr. PMCID: PMC2077276 Immunology HIV turns plasmacytoid dendritic cells (pDC) into TRAIL-expressing killer pDC and down-regulates HIV coreceptors by Toll-like receptor 7-induced IFN-α Andrew W. Hardy, David R. Graham, Gene M. Shearer, and Jean-Philippe Herbeuval PMCID: PMC2077277 The role of CD8+CD28− regulatory cells in suppressing myasthenia gravis-associated responses by a dual altered peptide ligand Hava Ben-David, Amir Sharabi, Molly Dayan, Michael Sela, and Edna Mozes PMCID: PMC2077278 Medical Sciences Real-time imaging of β-catenin dynamics in cells and living mice Snehal Naik and David Piwnica-Worms PMCID: PMC2077279 Blood group O protects against severe Plasmodium falciparum malaria through the mechanism of reduced rosetting J. Alexandra Rowe, Ian G. Handel, Mahamadou A. Thera, Anne-Marie Deans, Kirsten E. Lyke, Abdoulaye Koné, Dapa A. Diallo, Ahmed Raza, Oscar Kai, Kevin Marsh, Christopher V. Plowe, Ogobara K. Doumbo, and Joann M. Moulds PMCID: PMC2077280 Antibodies to CD4-induced sites in HIV gp120 correlate with the control of SHIV challenge in macaques vaccinated with subunit immunogens Anthony DeVico, Timothy Fouts, George K. Lewis, Robert C. Gallo, Karla Godfrey, Manhattan Charurat, Ilia Harris, Lindsey Galmin, and Ranajit Pal PMCID: PMC2077281 Murine models of acute neuronopathic Gaucher disease Ida Berglin Enquist, Christophe Lo Bianco, Andreas Ooka, Eva Nilsson, Jan-Eric Månsson, Mats Ehinger, Johan Richter, Roscoe O. Brady, Deniz Kirik, and Stefan Karlsson PMCID: PMC2077282 Positron emission tomography (PET) imaging of neuroblastoma and melanoma with 64Cu-SarAr immunoconjugates Stephan D. Voss, Suzanne V. Smith, Nadine DiBartolo, Lacey J. McIntosh, Erika M. Cyr, Ali A. Bonab, Jason L. J. Dearling, Edward A. Carter, Alan J. Fischman, S. Ted Treves, Stephen D. Gillies, Alan M. Sargeson, James S. Huston, and Alan B. Packard PMCID: PMC2077283 Identification of differentially expressed proteins in ovarian cancer using high-density protein microarrays Michael E. Hudson, Irina Pozdnyakova, Kenneth Haines, Gil Mor, and Michael Snyder PMCID: PMC2077284 Sulforaphane mobilizes cellular defenses that protect skin against damage by UV radiation Paul Talalay, Jed W. Fahey, Zachary R. Healy, Scott L. Wehage, Andrea L. Benedict, Christine Min, and Albena T. Dinkova-Kostova PMCID: PMC2077285 Microbiology Changes in viral protein function that accompany retroviral endogenization Nidia M. Oliveira, Harshita Satija, I. Arlette Kouwenhoven, and Maribeth V. Eiden PMCID: PMC2077286 Digital holographic microscopy reveals prey-induced changes in swimming behavior of predatory dinoflagellates Jian Sheng, Edwin Malkiel, Joseph Katz, Jason Adolf, Robert Belas, and Allen R. Place PMCID: PMC2077287 Neuroscience Loss of Vac14, a regulator of the signaling lipid phosphatidylinositol 3,5-bisphosphate, results in neurodegeneration in mice Yanling Zhang, Sergey N. Zolov, Clement Y. Chow, Shalom G. Slutsky, Simon C. Richardson, Robert C. Piper, Baoli Yang, Johnathan J. Nau, Randal J. Westrick, Sean J. Morrison, Miriam H. Meisler, and Lois S. Weisman PMCID: PMC2077288 From the Cover:
Loss of Bardet–Biedl syndrome proteins causes defects in peripheral sensory innervation and function Perciliz L. Tan, Travis Barr, Peter N. Inglis, Norimasa Mitsuma, Susan M. Huang, Miguel A. Garcia-Gonzalez, Brian A. Bradley, Stephanie Coforio, Phillip J. Albrecht, Terry Watnick, Gregory G. Germino, Philip L. Beales, Michael J. Caterina, Michel R. Leroux, Frank L. Rice, and Nicholas Katsanis PMCID: PMC2077289 Impaired hippocampal rhythmogenesis in a mouse model of mesial temporal lobe epilepsy Tamar Dugladze, Imre Vida, Adriano B. Tort, Anna Gross, Jacub Otahal, Uwe Heinemann, Nancy J. Kopell, and Tengis Gloveli PMCID: PMC2077290 Reduced cortical inhibition in a mouse model of familial childhood absence epilepsy Heneu O. Tan, Christopher A. Reid, Frank N. Single, Philip J. Davies, Cindy Chiu, Susan Murphy, Alison L. Clarke, Leanne Dibbens, Heinz Krestel, John C. Mulley, Mathew V. Jones, Peter H. Seeburg, Bert Sakmann, Samuel F. Berkovic, Rolf Sprengel, and Steven Petrou PMCID: PMC2077291 Physiology Attenuation of store-operated Ca2+ current impairs salivary gland fluid secretion in TRPC1(−/−) mice Xibao Liu, Kwong Tai Cheng, Bidhan C. Bandyopadhyay, Biswaranjan Pani, Alexander Dietrich, Biman C. Paria, William D. Swaim, David Beech, Eda Yildrim, Brij B. Singh, Lutz Birnbaumer, and Indu S. Ambudkar PMCID: PMC2077292 Plant Biology Potential for hydrogen production with inducible chloroplast gene expression in Chlamydomonas Raymond Surzycki, Laurent Cournac, Gilles Peltier, and Jean-David Rochaix PMCID: PMC2077293 Social Sciences Economic Sciences Nonstationary increments, scaling distributions, and variable diffusion processes in financial markets Kevin E. Bassler, Joseph L. McCauley, and Gemunu H. Gunaratne PMCID: PMC2077248 Social Sciences Gossip as an alternative for direct observation in games of indirect reciprocity Ralf D. Sommerfeld, Hans-Jürgen Krambeck, Dirk Semmann, and Manfred Milinski PMCID: PMC2077274 Corrections Correction for Gao et al., Combinatorial activities of Akt and B-Raf/Erk signaling in a mouse model of androgen-independent prostate cancer PMCID: PMC2077294 Corrects: Hui Gao, et al. Combinatorial activities of Akt and B-Raf/Erk signaling in a mouse model of androgen-independent prostate cancer. Proc Natl Acad Sci U S A. 2006 September 26; 103(39): 14477–14482. Correction for Forte et al., Cyclophilin D inactivation protects axons in experimental autoimmune encephalomyelitis, an animal model of multiple sclerosis PMCID: PMC2077295 Corrects: Michael Forte, et al. Cyclophilin D inactivation protects axons in experimental autoimmune encephalomyelitis, an animal model of multiple sclerosis. Proc Natl Acad Sci U S A. 2007 May 1; 104(18): 7558–7563. Correction for Beckers et al., The mouse homeobox gene Noto regulates node morphogenesis, notochordal ciliogenesis, and left–right patterning PMCID: PMC2077296 Corrects: Anja Beckers, et al. The mouse homeobox gene Noto regulates node morphogenesis, notochordal ciliogenesis, and left–right patterning. Proc Natl Acad Sci U S A. 2007 October 2; 104(40): 15765–15770. Correction for Hamon et al., Histone modifications induced by a family of bacterial toxins PMCID: PMC2077297 Corrects: Mélanie Anne Hamon, et al. Histone modifications induced by a family of bacterial toxins. Proc Natl Acad Sci U S A. 2007 August 14; 104(33): 13467–13472. |
