| | This journal provides immediate access to some articles. From the Academy German-American Frontiers of Science Symposium Introduction to German–American Frontiers of Science PMCID: PMC58495 Black holes B. Brügmann, A. M. Ghez, and J. Greiner PMCID: PMC58496 Single molecules Th. Basché, S. Nie, and J. M. Fernandez PMCID: PMC58497 Global climate models: Past, present, and future Martin Stute, Amy Clement, and Gerrit Lohmann PMCID: PMC58498 Random matrices and quantum chaos Thomas Kriecherbauer, Jens Marklof, and Alexander Soshnikov PMCID: PMC58499 Commentaries Seeing is believing: Visualization of rafts in model membranes Deborah A. Brown PMCID: PMC58492 Methylation patterns and mathematical models reveal dynamics of stem cell turnover in the human colon Simon Ro and Bruce Rannala PMCID: PMC58493 From Alzheimer's disease to skin tumors: The catenin connection Dieter Hartmann PMCID: PMC58494 Physical Sciences Chemistry INAUGURAL ARTICLE by a Recently Elected Academy Member: Water clusters: Untangling the mysteries of the liquid, one molecule at a time Frank N. Keutsch and Richard J. Saykally PMCID: PMC58500 Solvent interactions determine carbohydrate conformation Karl N. Kirschner and Robert J. Woods PMCID: PMC58501 Dominant/recessive behavior in the expression of molecular information: Self-assembly of inorganic macrocyclic architectures containing coordinatively unsaturated ligands Daniel P. Funeriu, Kari Rissanen, and Jean-Marie P. Lehn PMCID: PMC58502 Geology From the Cover:
Pronounced climatic variations in Alaska during the last two millennia Feng Sheng Hu, Emi Ito, Thomas A. Brown, B. Brandon Curry, and Daniel R. Engstrom PMCID: PMC58503 Statistics A note on Kalman Filter C. R. Rao PMCID: PMC58504 Biological Sciences Biochemistry Biosynthesis of a fluorescent cyanobacterial C-phycocyanin holo-α subunit in a heterologous host Aaron J. Tooley, Yuping A. Cai, and Alexander N. Glazer PMCID: PMC58505 Genetic engineering of phytochrome biosynthesis in bacteria Gregory A. Gambetta and J. Clark Lagarias PMCID: PMC58506 Cloning and characterization of a histone deacetylase, HDAC9 Xianbo Zhou, Paul A. Marks, Richard A. Rifkind, and Victoria M. Richon PMCID: PMC58507 In vivo mechanism-based inactivation of S-adenosylmethionine decarboxylases from Escherichia coli, Salmonella typhimurium, and Saccharomyces cerevisiae Yong-Fu Li, Sonja Hess, Lewis K. Pannell, Celia White Tabor, and Herbert Tabor PMCID: PMC58508 Overlapping recognition determinants within the ssrA degradation tag allow modulation of proteolysis Julia M. Flynn, Igor Levchenko, Meredith Seidel, Sue H. Wickner, Robert T. Sauer, and Tania A. Baker PMCID: PMC58509 Inhibition of transcription factor-DNA complexes and gene expression by a microgonotropen Christine M. White, Alexander L. Satz, Thomas C. Bruice, and Terry A. Beerman PMCID: PMC58510 Searching sequence space for protein catalysts Sean V. Taylor, Kai U. Walter, Peter Kast, and Donald Hilvert PMCID: PMC58511 Structural features of an influenza virus promoter and their implications for viral RNA synthesis Sung-Hun Bae, Hae-Kap Cheong, Joon-Hwa Lee, Chaejoon Cheong, Masatsune Kainosho, and Byong-Seok Choi PMCID: PMC58512 Human mitochondrial topoisomerase I Hongliang Zhang, Juana M. Barceló, Benson Lee, Glenda Kohlhagen, Drazen B. Zimonjic, Nicholas C. Popescu, and Yves Pommier PMCID: PMC58513 Biosynthesis and insecticidal properties of plant cyclotides: The cyclic knotted proteins from Oldenlandia affinis Cameron Jennings, Jenny West, Clement Waine, David Craik, and Marilyn Anderson PMCID: PMC58514 Effect of spermidine on the in vivo degradation of ornithine decarboxylase in Saccharomyces cerevisiae Rashmi Gupta, Nobuko Hamasaki-Katagiri, Celia White Tabor, and Herbert Tabor PMCID: PMC58515 A chemical inhibitor of N-WASP reveals a new mechanism for targeting protein interactions Jeffrey R. Peterson, R. Scott Lokey, Timothy J. Mitchison, and Marc W. Kirschner PMCID: PMC58516 Genomic profiling of short- and long-term caloric restriction effects in the liver of aging mice Shelley X. Cao, Joseph M. Dhahbi, Patricia L. Mote, and Stephen R. Spindler PMCID: PMC58517 Biophysics Protein docking along smooth association pathways Carlos J. Camacho and Sandor Vajda PMCID: PMC58518 From the Cover:
Partitioning of Thy-1, GM1, and cross-linked phospholipid analogs into lipid rafts reconstituted in supported model membrane monolayers Christian Dietrich, Zoya N. Volovyk, Moshe Levi, Nancy L. Thompson, and Ken Jacobson PMCID: PMC58519 Multiwavelength anomalous diffraction analysis at the M absorption edges of uranium Yee Liu, Craig M. Ogata, and Wayne A. Hendrickson PMCID: PMC58520 Functionalized xenon as a biosensor Megan M. Spence, Seth M. Rubin, Ivan E. Dimitrov, E. Janette Ruiz, David E. Wemmer, Alexander Pines, Shao Qin Yao, Feng Tian, and Peter G. Schultz PMCID: PMC58521 Compaction of single DNA molecules induced by binding of integration host factor (IHF) B. M. Jaffar Ali, Roee Amit, Ido Braslavsky, Amos B. Oppenheim, Opher Gileadi, and Joel Stavans PMCID: PMC58522 History dependence of protein adsorption kinetics Claudio Calonder, Yanrong Tie, and Paul R. Van Tassel PMCID: PMC58523 Hydration of the peptide backbone largely defines the thermodynamic propensity scale of residues at the C′ position of the C-capping box of α-helices Susan T. Thomas, Vakhtang V. Loladze, and George I. Makhatadze PMCID: PMC58524 The plug domain of FepA, a TonB-dependent transport protein from Escherichia coli, binds its siderophore in the absence of the transmembrane barrel domain Ken C. Usher, Engin Özkan, Kevin H. Gardner, and Johann Deisenhofer PMCID: PMC58525 Multiple conformations of PEVK proteins detected by single-molecule techniques Hongbin Li, Andres F. Oberhauser, Sambra D. Redick, Mariano Carrion-Vazquez, Harold P. Erickson, and Julio M. Fernandez PMCID: PMC58526 Conversion of monomeric protein L to an obligate dimer by computational protein design Brian Kuhlman, Jason W. O'Neill, David E. Kim, Kam Y. J. Zhang, and David Baker PMCID: PMC58527 Cell Biology Regulation of melastatin, a TRP-related protein, through interaction with a cytoplasmic isoform X.-Z. Shawn Xu, Fabian Moebius, Donald L. Gill, and Craig Montell PMCID: PMC58528 A model for melanosome biogenesis based on the purification and analysis of early melanosomes Tsuneto Kushimoto, Venkatesha Basrur, Julio Valencia, Jun Matsunaga, Wilfred D. Vieira, Victor J. Ferrans, Jacqueline Muller, Ettore Appella, and Vincent J. Hearing PMCID: PMC58529 Structure of the Sec23p/24p and Sec13p/31p complexes of COPII Gerardo Z. Lederkremer, Yifan Cheng, Benjamin M. Petre, Erik Vogan, Sebastian Springer, Randy Schekman, Thomas Walz, and Tomas Kirchhausen PMCID: PMC58530 Immunolocalization of UDP-glucose:glycoprotein glucosyltransferase indicates involvement of pre-Golgi intermediates in protein quality control Christian Zuber, Jing-yu Fan, Bruno Guhl, Armando Parodi, John H. Fessler, Carol Parker, and Jürgen Roth PMCID: PMC58531 Hematopoietic colony-forming cells derived from human embryonic stem cells Dan S. Kaufman, Eric T. Hanson, Rachel L. Lewis, Robert Auerbach, and James A. Thomson PMCID: PMC58532 Suppression of Ras-mediated tumorigenicity and metastasis through inhibition of the Met receptor tyrosine kinase Kyle A. Furge, David Kiewlich, Phuong Le, My Nga Vo, Michel Faure, Anthony R. Howlett, Kenneth E. Lipson, George F. Vande Woude, and Craig P. Webb PMCID: PMC58533 Developmental Biology Rhesus monkey placental transgene expression after lentiviral gene transfer into preimplantation embryos M. J. Wolfgang, S. G. Eisele, M. A. Browne, M. L. Schotzko, M. A. Garthwaite, M. Durning, A. Ramezani, R. G. Hawley, J. A. Thomson, and T. G. Golos PMCID: PMC58541 From the Cover:
Cardiomyocytes induce endothelial cells to trans-differentiate into cardiac muscle: Implications for myocardium regeneration G. Condorelli, U. Borello, L. De Angelis, M. Latronico, D. Sirabella, M. Coletta, R. Galli, G. Balconi, A. Follenzi, G. Frati, M. G. Cusella De Angelis, L. Gioglio, S. Amuchastegui, L. Adorini, L. Naldini, A. Vescovi, E. Dejana, and G. Cossu PMCID: PMC58544 Diverse developmental programs of Xenopus laevis metamorphosis are inhibited by a dominant negative thyroid hormone receptor Alexander M. Schreiber, Biswajit Das, Haochu Huang, Nicholas Marsh-Armstrong, and Donald D. Brown PMCID: PMC58545 Evolution Lateral transfer at the gene and subgenic levels in the evolution of eukaryotic enolase Patrick J. Keeling and Jeffrey D. Palmer PMCID: PMC58546 Incomplete taxon sampling is not a problem for phylogenetic inference Michael S. Rosenberg and Sudhir Kumar PMCID: PMC58547 Reward and punishment Karl Sigmund, Christoph Hauert, and Martin A. Nowak PMCID: PMC58548 Receptor-like kinases from Arabidopsis form a monophyletic gene family related to animal receptor kinases Shin-Han Shiu and Anthony B. Bleecker PMCID: PMC58549 When genetic distance matters: Measuring genetic differentiation at microsatellite loci in whole-genome scans of recent and incipient mosquito species Rui Wang, Liangbiao Zheng, Yeya T. Touré, Thomas Dandekar, and Fotis C. Kafatos PMCID: PMC58550 Genetics Tetracycline-inducible systems for Drosophila Michael J. Stebbins, Stefanie Urlinger, Gerry Byrne, Bruno Bello, Wolfgang Hillen, and Jerry C. P. Yin PMCID: PMC58551 Correspondence analysis applied to microarray data Kurt Fellenberg, Nicole C. Hauser, Benedikt Brors, Albert Neutzner, Jörg D. Hoheisel, and Martin Vingron PMCID: PMC58552 Chemosensitivity prediction by transcriptional profiling Jane E. Staunton, Donna K. Slonim, Hilary A. Coller, Pablo Tamayo, Michael J. Angelo, Johnny Park, Uwe Scherf, Jae K. Lee, William O. Reinhold, John N. Weinstein, Jill P. Mesirov, Eric S. Lander, and Todd R. Golub PMCID: PMC58553 Identification of a new malaria susceptibility locus (Char4) in recombinant congenic strains of mice Anny Fortin, Lon R. Cardon, Mifong Tam, Emil Skamene, Mary M. Stevenson, and Philippe Gros PMCID: PMC58554 Immunology Crystal structure of the human CD4 N-terminal two-domain fragment complexed to a class II MHC molecule Jia-huai Wang, Rob Meijers, Yi Xiong, Jin-huan Liu, Toshiko Sakihama, Rongguang Zhang, Andrzej Joachimiak, and Ellis L. Reinherz PMCID: PMC59561 Single-cell analysis of signal transduction in CD4 T cells stimulated by antigen in vivo Traci Zell, Alexander Khoruts, Elizabeth Ingulli, Jody L. Bonnevier, Daniel L. Mueller, and Marc K. Jenkins PMCID: PMC58555 CD40 stimulation accelerates deletion of tumor-specific CD8+ T cells in the absence of tumor-antigen vaccination Ross M. Kedl, Michael Jordan, Terence Potter, John Kappler, Philippa Marrack, and Steven Dow PMCID: PMC58556 Induction of CD4+ T cell-dependent CD8+ type 1 responses in humans by a malaria DNA vaccine Ruobing Wang, Judith Epstein, Fe Maria Baraceros, Edward J. Gorak, Yupin Charoenvit, Daniel J. Carucci, Richard C. Hedstrom, Nancy Rahardjo, Tanya Gay, Peter Hobart, Rick Stout, Trevor R. Jones, Thomas L. Richie, Suezanne E. Parker, Denise L. Doolan, Jon Norman, and Stephen L. Hoffman PMCID: PMC58557 Medical Sciences Prostatic intraepithelial neoplasia in mice expressing an androgen receptor transgene in prostate epithelium Michael Stanbrough, Irwin Leav, Paul W. L. Kwan, Glenn J. Bubley, and Steven P. Balk PMCID: PMC58558 Immune mimicry in malaria: Plasmodium falciparum secretes a functional histamine-releasing factor homolog in vitro and in vivo Susan M. MacDonald, Jamaree Bhisutthibhan, Theresa A. Shapiro, Stephen J. Rogerson, Terrie E. Taylor, Madalitso Tembo, Jacqueline M. Langdon, and Steven R. Meshnick PMCID: PMC58559 The histone deacetylase inhibitor and chemotherapeutic agent suberoylanilide hydroxamic acid (SAHA) induces a cell-death pathway characterized by cleavage of Bid and production of reactive oxygen species Astrid A. Ruefli, Michael J. Ausserlechner, David Bernhard, Vivien R. Sutton, Kellie M. Tainton, Reinhard Kofler, Mark J. Smyth, and Ricky W. Johnstone PMCID: PMC58560 From the Cover:
Investigating stem cells in human colon by using methylation patterns Yasushi Yatabe, Simon Tavaré, and Darryl Shibata PMCID: PMC58561 Nitric oxide-induced apoptosis in pancreatic β cells is mediated by the endoplasmic reticulum stress pathway Seiichi Oyadomari, Kiyoshi Takeda, Masaki Takiguchi, Tomomi Gotoh, Makoto Matsumoto, Ikuo Wada, Shizuo Akira, Eiichi Araki, and Masataka Mori PMCID: PMC58562 Oligodendrocyte lineage genes (OLIG) as molecular markers for human glial brain tumors Q. Richard Lu, John K. Park, Elizabeth Noll, Jennifer A. Chan, John Alberta, Dongin Yuk, M. Garcia Alzamora, David N. Louis, Charles D. Stiles, David H. Rowitch, and Peter M. Black PMCID: PMC58563 Inhibition of both paracrine and autocrine VEGF/ VEGFR-2 signaling pathways is essential to induce long-term remission of xenotransplanted human leukemias Sergio Dias, Koichi Hattori, Beate Heissig, Zhenping Zhu, Yan Wu, Larry Witte, Daniel J. Hicklin, Masatoshi Tateno, Peter Bohlen, Malcolm A. S. Moore, and Shahin Rafii PMCID: PMC58564 Loss of presenilin 1 is associated with enhanced β-catenin signaling and skin tumorigenesis Xuefeng Xia, Su Qian, Salvador Soriano, Ying Wu, Anthony M. Fletcher, Xiao-Jing Wang, Edward H. Koo, Xiangwei Wu, and Hui Zheng PMCID: PMC58565 Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications Therese Sørlie, Charles M. Perou, Robert Tibshirani, Turid Aas, Stephanie Geisler, Hilde Johnsen, Trevor Hastie, Michael B. Eisen, Matt van de Rijn, Stefanie S. Jeffrey, Thor Thorsen, Hanne Quist, John C. Matese, Patrick O. Brown, David Botstein, Per Eystein Lønning, and Anne-Lise Børresen-Dale PMCID: PMC58566 Microbiology Modulation of HIV-like particle assembly in vitro by inositol phosphates Stephen Campbell, Robert J. Fisher, Eric M. Towler, Stephen Fox, Haleem J. Issaq, Tracy Wolfe, Lawrence R. Phillips, and Alan Rein PMCID: PMC58567 A role for IL-1α in inducing pathologic inflammation during bacterial infection Peter H. Dube, Paula A. Revell, David D. Chaplin, Robin G. Lorenz, and Virginia L. Miller PMCID: PMC58568 An acquired and a native penicillin-binding protein cooperate in building the cell wall of drug-resistant staphylococci Mariana G. Pinho, Hermínia de Lencastre, and Alexander Tomasz PMCID: PMC58569 A simple model host for identifying Gram-positive virulence factors Danielle A. Garsin, Costi D. Sifri, Eleftherios Mylonakis, Xiang Qin, Kavindra V. Singh, Barbara E. Murray, Stephen B. Calderwood, and Frederick M. Ausubel PMCID: PMC58570 Replication of enhancer-deficient amphotropic murine leukemia virus in human cells Frank U. Reuss, Bianca Berdel, Martin Ploss, and Ricarda Heber PMCID: PMC58571 Neurobiology Localized cerebral blood flow response at submillimeter columnar resolution Timothy Q. Duong, Dae-Shik Kim, Kâmil Uğurbil, and Seong-Gi Kim PMCID: PMC58572 INAUGURAL ARTICLE by a Recently Elected Academy Member: Adult-generated hippocampal and neocortical neurons in macaques have a transient existence E. Gould, N. Vail, M. Wagers, and C. G. Gross PMCID: PMC58573 An AAV-derived Apaf-1 dominant negative inhibitor prevents MPTP toxicity as antiapoptotic gene therapy for Parkinson's disease Hideki Mochizuki, Hideki Hayakawa, Makoto Migita, Mamoru Shibata, Ryota Tanaka, Asuka Suzuki, Yumi Shimo-Nakanishi, Takao Urabe, Masanori Yamada, Kenji Tamayose, Takashi Shimada, Masayuki Miura, and Yoshikuni Mizuno PMCID: PMC58574 Heterosynaptic metaplasticity in the hippocampus in vivo: A BCM-like modifiable threshold for LTP Wickliffe C. Abraham, Sara E. Mason-Parker, Mark F. Bear, Sarah Webb, and Warren P. Tate PMCID: PMC58575 A src family tyrosine kinase inhibits neurotransmitter release from neuronal cells Hiroshi Ohnishi, Saori Yamamori, Kanako Ono, Kyota Aoyagi, Shunzo Kondo, and Masami Takahashi PMCID: PMC58576 Pharmacology Distinct effects of cAMP and mitogenic signals on CREB-binding protein recruitment impart specificity to target gene activation via CREB Bernhard M. Mayr, Gianluca Canettieri, and Marc R. Montminy PMCID: PMC58577 Quinine blocks specific gap junction channel subtypes Miduturu Srinivas, Matthew G. Hopperstad, and David C. Spray PMCID: PMC58578 Physiology Local uncaging of caged Ca2+ reveals distribution of Ca2+-activated Cl− channels in pancreatic acinar cells Myoung Kyu Park, Richard B. Lomax, Alexei V. Tepikin, and Ole H. Petersen PMCID: PMC58579 Plant Biology Plant gene expression response to Agrobacterium tumefaciens Renata F. Ditt, Eugene W. Nester, and Luca Comai PMCID: PMC58580 Two types of MGDG synthase genes, found widely in both 16:3 and 18:3 plants, differentially mediate galactolipid syntheses in photosynthetic and nonphotosynthetic tissues in Arabidopsis thaliana Koichiro Awai, Eric Maréchal, Maryse A. Block, Delphine Brun, Tatsuru Masuda, Hiroshi Shimada, Ken-ichiro Takamiya, Hiroyuki Ohta, and Jacques Joyard PMCID: PMC58581 Psychology Prediction of cognitive decline in normal elderly subjects with 2-[18F]fluoro-2-deoxy-d-glucose/positron-emission tomography (FDG/PET) M. J. de Leon, A. Convit, O. T. Wolf, C. Y. Tarshish, S. DeSanti, H. Rusinek, W. Tsui, E. Kandil, A. J. Scherer, A. Roche, A. Imossi, E. Thorn, M. Bobinski, C. Caraos, P. Lesbre, D. Schlyer, J. Poirier, B. Reisberg, and J. Fowler PMCID: PMC58582 Social Sciences Anthropology Stone tool function at the paleolithic sites of Starosele and Buran Kaya III, Crimea: Behavioral implications Bruce L. Hardy, Marvin Kay, Anthony E. Marks, and Katherine Monigal PMCID: PMC58583 |
