| | This journal provides immediate access to some articles. This Week in PNAS Proc Natl Acad Sci U S A. 2006 November 14; 103(46): 17067–17068. doi: 10.1073/iti4606103.PMCID: PMC1859887 Commentaries Hedgehogs like it sweet, too Andrew Beenken and Moosa Mohammadi Proc Natl Acad Sci U S A. 2006 November 14; 103(46): 17069–17070. Published online 2006 November 6. doi: 10.1073/pnas.0608456103.PMCID: PMC1859888 Germ cells carry the epigenetic benefits of grandmother's diet Craig A. Cooney Proc Natl Acad Sci U S A. 2006 November 14; 103(46): 17071–17072. Published online 2006 November 13. doi: 10.1073/pnas.0608653103.PMCID: PMC1859889 Circulating tumor cells in breast cancer: Advanced tools for “tailored” therapy? Massimo Cristofanilli and John Mendelsohn Proc Natl Acad Sci U S A. 2006 November 14; 103(46): 17073–17074. Published online 2006 November 7. doi: 10.1073/pnas.0608651103.PMCID: PMC1859890 Perspective Nobel Lecture War and peace Robert J. Aumann Proc Natl Acad Sci U S A. 2006 November 14; 103(46): 17075–17078. Published online 2006 November 8. doi: 10.1073/pnas.0608329103.PMCID: PMC1859891 Nitrogen Fixation Special Feature Introductory Perspective Reduction of dinitrogen Richard R. Schrock Proc Natl Acad Sci U S A. 2006 November 14; 103(46): 17087. Published online 2006 November 6. doi: 10.1073/pnas.0603633103.PMCID: PMC1859893 Research Articles Inner-sphere two-electron reduction leads to cleavage and functionalization of coordinated dinitrogen Liam P. Spencer, Bruce A. MacKay, Brian O. Patrick, and Michael D. Fryzuk Proc Natl Acad Sci U S A. 2006 November 14; 103(46): 17094–17098. Published online 2006 October 18. doi: 10.1073/pnas.0602132103.PMCID: PMC1693869 Catalytic reduction of dinitrogen to ammonia at a single molybdenum center Walter W. Weare, Xuliang Dai, Matthew J. Byrnes, Jia Min Chin, Richard R. Schrock, and Peter Müller Proc Natl Acad Sci U S A. 2006 November 14; 103(46): 17099–17106. Published online 2006 November 3. doi: 10.1073/pnas.0602778103.PMCID: PMC1693870 On the feasibility of N 2 fixation via a single-site Fe I/Fe IV cycle: Spectroscopic studies of Fe I(N 2)Fe I, Fe IVN, and related species Michael P. Hendrich, William Gunderson, Rachel K. Behan, Michael T. Green, Mark P. Mehn, Theodore A. Betley, Connie C. Lu, and Jonas C. Peters Proc Natl Acad Sci U S A. 2006 November 14; 103(46): 17107–17112. Published online 2006 November 7. doi: 10.1073/pnas.0604402103.PMCID: PMC1693871 A methyldiazene (HN N CH 3)-derived species bound to the nitrogenase active-site FeMo cofactor: Implications for mechanism Brett M. Barney, Dmitriy Lukoyanov, Tran-Chin Yang, Dennis R. Dean, Brian M. Hoffman, and Lance C. Seefeldt Proc Natl Acad Sci U S A. 2006 November 14; 103(46): 17113–17118. Published online 2006 November 6. doi: 10.1073/pnas.0602130103.PMCID: PMC1693872 From the Cover: Nitrogen Fixation Special Feature: FeMo cofactor maturation on NifEN Yilin Hu, Mary C. Corbett, Aaron W. Fay, Jerome A. Webber, Keith O. Hodgson, Britt Hedman, and Markus W. Ribbe Proc Natl Acad Sci U S A. 2006 November 14; 103(46): 17119–17124. Published online 2006 October 18. doi: 10.1073/pnas.0602647103.PMCID: PMC1859895 From the Cover: Nitrogen Fixation Special Feature: Nitrogenase Fe protein: A molybdate/homocitrate insertase Yilin Hu, Mary C. Corbett, Aaron W. Fay, Jerome A. Webber, Keith O. Hodgson, Britt Hedman, and Markus W. Ribbe Proc Natl Acad Sci U S A. 2006 November 14; 103(46): 17125–17130. Published online 2006 October 24. doi: 10.1073/pnas.0602651103.PMCID: PMC1859896 Flavodoxin hydroquinone reduces Azotobacter vinelandii Fe protein to the all-ferrous redox state with a S = 0 spin state Thomas J. Lowery, Phillip E. Wilson, Bo Zhang, Jared Bunker, Roger G. Harrison, Andrew C. Nyborg, David Thiriot, and Gerald D. Watt Proc Natl Acad Sci U S A. 2006 November 14; 103(46): 17131–17136. Published online 2006 November 3. doi: 10.1073/pnas.0603223103.PMCID: PMC1859897 Perspective How many metals does it take to fix N2? A mechanistic overview of biological nitrogen fixation James B. Howard and Douglas C. Rees Proc Natl Acad Sci U S A. 2006 November 14; 103(46): 17088–17093. Published online 2006 November 6. doi: 10.1073/pnas.0603978103.PMCID: PMC1859894 Physical Sciences Applied Physical Sciences Adaptive wavefront correction in two-photon microscopy using coherence-gated wavefront sensing Markus Rueckel, Julia A. Mack-Bucher, and Winfried Denk Proc Natl Acad Sci U S A. 2006 November 14; 103(46): 17137–17142. Published online 2006 November 6. doi: 10.1073/pnas.0604791103.PMCID: PMC1634839 Quantitative multispectral biosensing and 1D imaging using quasi-3D plasmonic crystals Matthew E. Stewart, Nathan H. Mack, Viktor Malyarchuk, Julio A. N. T. Soares, Tae-Woo Lee, Stephen K. Gray, Ralph G. Nuzzo, and John A. Rogers Proc Natl Acad Sci U S A. 2006 November 14; 103(46): 17143–17148. Published online 2006 November 3. doi: 10.1073/pnas.0606216103.PMCID: PMC1634412 Two-photon vibrational spectroscopy for biosciences based on surface-enhanced hyper-Raman scattering Janina Kneipp, Harald Kneipp, and Katrin Kneipp Proc Natl Acad Sci U S A. 2006 November 14; 103(46): 17149–17153. Published online 2006 November 6. doi: 10.1073/pnas.0608262103.PMCID: PMC1634837 Chemistry Inner-sphere two-electron reduction leads to cleavage and functionalization of coordinated dinitrogen Liam P. Spencer, Bruce A. MacKay, Brian O. Patrick, and Michael D. Fryzuk Proc Natl Acad Sci U S A. 2006 November 14; 103(46): 17094–17098. Published online 2006 October 18. doi: 10.1073/pnas.0602132103.PMCID: PMC1693869 Catalytic reduction of dinitrogen to ammonia at a single molybdenum center Walter W. Weare, Xuliang Dai, Matthew J. Byrnes, Jia Min Chin, Richard R. Schrock, and Peter Müller Proc Natl Acad Sci U S A. 2006 November 14; 103(46): 17099–17106. Published online 2006 November 3. doi: 10.1073/pnas.0602778103.PMCID: PMC1693870 On the feasibility of N 2 fixation via a single-site Fe I/Fe IV cycle: Spectroscopic studies of Fe I(N 2)Fe I, Fe IVN, and related species Michael P. Hendrich, William Gunderson, Rachel K. Behan, Michael T. Green, Mark P. Mehn, Theodore A. Betley, Connie C. Lu, and Jonas C. Peters Proc Natl Acad Sci U S A. 2006 November 14; 103(46): 17107–17112. Published online 2006 November 7. doi: 10.1073/pnas.0604402103.PMCID: PMC1693871 A methyldiazene (HN N CH 3)-derived species bound to the nitrogenase active-site FeMo cofactor: Implications for mechanism Brett M. Barney, Dmitriy Lukoyanov, Tran-Chin Yang, Dennis R. Dean, Brian M. Hoffman, and Lance C. Seefeldt Proc Natl Acad Sci U S A. 2006 November 14; 103(46): 17113–17118. Published online 2006 November 6. doi: 10.1073/pnas.0602130103.PMCID: PMC1693872 The color of rhodopsins at the ab initio multiconfigurational perturbation theory resolution Pedro B. Coto, Angela Strambi, Nicolas Ferré, and Massimo Olivucci Proc Natl Acad Sci U S A. 2006 November 14; 103(46): 17154–17159. Published online 2006 November 7. doi: 10.1073/pnas.0604048103.PMCID: PMC1859901 Concatenated logic gates using four coupled biocatalysts operating in series Tamara Niazov, Ronan Baron, Eugenii Katz, Oleg Lioubashevski, and Itamar Willner Proc Natl Acad Sci U S A. 2006 November 14; 103(46): 17160–17163. Published online 2006 November 6. doi: 10.1073/pnas.0608319103.PMCID: PMC1634834 Engineering Blood flow velocity effects and role of activation delay time on growth and form of platelet thrombi Igor V. Pivkin, Peter D. Richardson, and George Karniadakis Proc Natl Acad Sci U S A. 2006 November 14; 103(46): 17164–17169. Published online 2006 November 3. doi: 10.1073/pnas.0608546103.PMCID: PMC1859903 Environmental Sciences The potential rate of bed-load transport Basil Gomez Proc Natl Acad Sci U S A. 2006 November 14; 103(46): 17170–17173. Published online 2006 November 6. doi: 10.1073/pnas.0608487103.PMCID: PMC1859904 Bacterial metapopulations in nanofabricated landscapes Juan E. Keymer, Peter Galajda, Cecilia Muldoon, Sungsu Park, and Robert H. Austin Proc Natl Acad Sci U S A. 2006 November 14; 103(46): 17290–17295. Published online 2006 November 7. doi: 10.1073/pnas.0607971103.PMCID: PMC1635019 Geology The potential rate of bed-load transport Basil Gomez Proc Natl Acad Sci U S A. 2006 November 14; 103(46): 17170–17173. Published online 2006 November 6. doi: 10.1073/pnas.0608487103.PMCID: PMC1859904 Physics Electrostatic origin of the genome packing in viruses Vladimir A. Belyi and M. Muthukumar Proc Natl Acad Sci U S A. 2006 November 14; 103(46): 17174–17178. Published online 2006 November 7. doi: 10.1073/pnas.0608311103.PMCID: PMC1859905 Emergent magnetic moments produced by self-damage in plutonium S. K. McCall, M. J. Fluss, B. W. Chung, M. W. McElfresh, D. D. Jackson, and G. F. Chapline Proc Natl Acad Sci U S A. 2006 November 14; 103(46): 17179–17183. Published online 2006 November 6. doi: 10.1073/pnas.0608552103.PMCID: PMC1859906 Statistics Genotypic predictors of human immunodeficiency virus type 1 drug resistance Soo-Yon Rhee, Jonathan Taylor, Gauhar Wadhera, Asa Ben-Hur, Douglas L. Brutlag, and Robert W. Shafer Proc Natl Acad Sci U S A. 2006 November 14; 103(46): 17355–17360. Published online 2006 October 25. doi: 10.1073/pnas.0607274103.PMCID: PMC1622926 Sustainability Science Feasibility of cooling the Earth with a cloud of small spacecraft near the inner Lagrange point (L1) Roger Angel Proc Natl Acad Sci U S A. 2006 November 14; 103(46): 17184–17189. Published online 2006 November 3. doi: 10.1073/pnas.0608163103.PMCID: PMC1859907 Biological Sciences Anthropology Recent Southeast Asian domestication and Lapita dispersal of sacred male pseudohermaphroditic “tuskers” and hairless pigs of Vanuatu J. Koji Lum, James K. McIntyre, Douglas L. Greger, Kirk W. Huffman, and Miguel G. Vilar Proc Natl Acad Sci U S A. 2006 November 14; 103(46): 17190–17195. Published online 2006 November 6. doi: 10.1073/pnas.0608220103.PMCID: PMC1859908 Early modern humans from the Peştera Muierii, Baia de Fier, Romania Andrei Soficaru, Adrian Doboş, and Erik Trinkaus Proc Natl Acad Sci U S A. 2006 November 14; 103(46): 17196–17201. Published online 2006 November 3. doi: 10.1073/pnas.0608443103.PMCID: PMC1859909 Applied Biological Sciences A critical role for IκB kinase α in the development of human and mouse squamous cell carcinomas Bigang Liu, Eunmi Park, Feng Zhu, Tracie Bustos, Jinsong Liu, Jianjun Shen, Susan M. Fischer, and Yinling Hu Proc Natl Acad Sci U S A. 2006 November 14; 103(46): 17202–17207. Published online 2006 November 1. doi: 10.1073/pnas.0604481103.PMCID: PMC1859910 Biochemistry A methyldiazene (HN N CH 3)-derived species bound to the nitrogenase active-site FeMo cofactor: Implications for mechanism Brett M. Barney, Dmitriy Lukoyanov, Tran-Chin Yang, Dennis R. Dean, Brian M. Hoffman, and Lance C. Seefeldt Proc Natl Acad Sci U S A. 2006 November 14; 103(46): 17113–17118. Published online 2006 November 6. doi: 10.1073/pnas.0602130103.PMCID: PMC1693872 From the Cover: Nitrogen Fixation Special Feature: FeMo cofactor maturation on NifEN Yilin Hu, Mary C. Corbett, Aaron W. Fay, Jerome A. Webber, Keith O. Hodgson, Britt Hedman, and Markus W. Ribbe Proc Natl Acad Sci U S A. 2006 November 14; 103(46): 17119–17124. Published online 2006 October 18. doi: 10.1073/pnas.0602647103.PMCID: PMC1859895 From the Cover: Nitrogen Fixation Special Feature: Nitrogenase Fe protein: A molybdate/homocitrate insertase Yilin Hu, Mary C. Corbett, Aaron W. Fay, Jerome A. Webber, Keith O. Hodgson, Britt Hedman, and Markus W. Ribbe Proc Natl Acad Sci U S A. 2006 November 14; 103(46): 17125–17130. Published online 2006 October 24. doi: 10.1073/pnas.0602651103.PMCID: PMC1859896 Flavodoxin hydroquinone reduces Azotobacter vinelandii Fe protein to the all-ferrous redox state with a S = 0 spin state Thomas J. Lowery, Phillip E. Wilson, Bo Zhang, Jared Bunker, Roger G. Harrison, Andrew C. Nyborg, David Thiriot, and Gerald D. Watt Proc Natl Acad Sci U S A. 2006 November 14; 103(46): 17131–17136. Published online 2006 November 3. doi: 10.1073/pnas.0603223103.PMCID: PMC1859897 From the Cover: Structure of a heparin-dependent complex of Hedgehog and Ihog Jason S. McLellan, Shenqin Yao, Xiaoyan Zheng, Brian V. Geisbrecht, Rodolfo Ghirlando, Philip A. Beachy, and Daniel J. Leahy Proc Natl Acad Sci U S A. 2006 November 14; 103(46): 17208–17213. Published online 2006 October 31. doi: 10.1073/pnas.0606738103.PMCID: PMC1859911 Structural and biochemical studies of the C-terminal domain of mouse peptide-N-glycanase identify it as a mannose-binding module Xiaoke Zhou, Gang Zhao, James J. Truglio, Liqun Wang, Guangtao Li, William J. Lennarz, and Hermann Schindelin Proc Natl Acad Sci U S A. 2006 November 14; 103(46): 17214–17219. Published online 2006 November 6. doi: 10.1073/pnas.0602954103.PMCID: PMC1859912 A single mutation in the castor Δ9-18:0-desaturase changes reaction partitioning from desaturation to oxidase chemistry Jodie E. Guy, Isabel A. Abreu, Martin Moche, Ylva Lindqvist, Edward Whittle, and John Shanklin Proc Natl Acad Sci U S A. 2006 November 14; 103(46): 17220–17224. Published online 2006 November 6. doi: 10.1073/pnas.0607165103.PMCID: PMC1859913 Insights into transcription enhancer factor 1 (TEF-1) activity from the solution structure of the TEA domain Asokan Anbanandam, Diana C. Albarado, Catherine T. Nguyen, Georg Halder, Xiaolian Gao, and Sudha Veeraraghavan Proc Natl Acad Sci U S A. 2006 November 14; 103(46): 17225–17230. Published online 2006 November 3. doi: 10.1073/pnas.0607171103.PMCID: PMC1859914 Structure of DNA polymerase β with a benzo[c]phenanthrene diol epoxide-adducted template exhibits mutagenic features Vinod K. Batra, David D. Shock, Rajendra Prasad, William A. Beard, Esther W. Hou, Lars C. Pedersen, Jane M. Sayer, Haruhiko Yagi, Subodh Kumar, Donald M. Jerina, and Samuel H. Wilson Proc Natl Acad Sci U S A. 2006 November 14; 103(46): 17231–17236. Published online 2006 November 1. doi: 10.1073/pnas.0605069103.PMCID: PMC1630674 Structural basis for protein–protein interactions in the 14-3-3 protein family Xiaowen Yang, Wen Hwa Lee, Frank Sobott, Evangelos Papagrigoriou, Carol V. Robinson, J. Günter Grossmann, Michael Sundström, Declan A. Doyle, and Jonathan M. Elkins Proc Natl Acad Sci U S A. 2006 November 14; 103(46): 17237–17242. Published online 2006 November 3. doi: 10.1073/pnas.0605779103.PMCID: PMC1859916 Discovery and in vitro biosynthesis of haloduracin, a two-component lantibiotic Amanda L. McClerren, Lisa E. Cooper, Chao Quan, Paul M. Thomas, Neil L. Kelleher, and Wilfred A. van der Donk Proc Natl Acad Sci U S A. 2006 November 14; 103(46): 17243–17248. Published online 2006 November 3. doi: 10.1073/pnas.0606088103.PMCID: PMC1859917 Biophysics Adaptive wavefront correction in two-photon microscopy using coherence-gated wavefront sensing Markus Rueckel, Julia A. Mack-Bucher, and Winfried Denk Proc Natl Acad Sci U S A. 2006 November 14; 103(46): 17137–17142. Published online 2006 November 6. doi: 10.1073/pnas.0604791103.PMCID: PMC1634839 The color of rhodopsins at the ab initio multiconfigurational perturbation theory resolution Pedro B. Coto, Angela Strambi, Nicolas Ferré, and Massimo Olivucci Proc Natl Acad Sci U S A. 2006 November 14; 103(46): 17154–17159. Published online 2006 November 7. doi: 10.1073/pnas.0604048103.PMCID: PMC1859901 Electrostatic origin of the genome packing in viruses Vladimir A. Belyi and M. Muthukumar Proc Natl Acad Sci U S A. 2006 November 14; 103(46): 17174–17178. Published online 2006 November 7. doi: 10.1073/pnas.0608311103.PMCID: PMC1859905 The 10+4 microfibril structure of thin cartilage fibrils David F. Holmes and Karl E. Kadler Proc Natl Acad Sci U S A. 2006 November 14; 103(46): 17249–17254. Published online 2006 November 6. doi: 10.1073/pnas.0608417103.PMCID: PMC1859918 Cell Biology INAUGURAL ARTICLE by a Recently Elected Academy Member: Podocin and MEC-2 bind cholesterol to regulate the activity of associated ion channels Tobias B. Huber, Bernhard Schermer, Roman Ulrich Müller, Martin Höhne, Malte Bartram, Andrea Calixto, Henning Hagmann, Christian Reinhardt, Fabienne Koos, Karl Kunzelmann, Elena Shirokova, Dietmar Krautwurst, Christian Harteneck, Matias Simons, Hermann Pavenstädt, Dontscho Kerjaschki, Christoph Thiele, Gerd Walz, Martin Chalfie, and Thomas Benzing Proc Natl Acad Sci U S A. 2006 November 14; 103(46): 17079–17086. Published online 2006 November 1. doi: 10.1073/pnas.0607465103.PMCID: PMC1859892 A three-dimensional model of myxobacterial fruiting-body formation Olga Sozinova, Yi Jiang, Dale Kaiser, and Mark Alber Proc Natl Acad Sci U S A. 2006 November 14; 103(46): 17255–17259. Published online 2006 November 6. doi: 10.1073/pnas.0605555103.PMCID: PMC1859919 VEGF, a prosurvival factor, acts in concert with TGF-β1 to induce endothelial cell apoptosis Giovanni Ferrari, Giuseppe Pintucci, Graziano Seghezzi, Kevin Hyman, Aubrey C. Galloway, and Paolo Mignatti Proc Natl Acad Sci U S A. 2006 November 14; 103(46): 17260–17265. Published online 2006 November 6. doi: 10.1073/pnas.0605556103.PMCID: PMC1859920 Self-renewal of embryonic stem cells by a small molecule Shuibing Chen, Jeong Tae Do, Qisheng Zhang, Shuyuan Yao, Feng Yan, Eric C. Peters, Hans R. Schöler, Peter G. Schultz, and Sheng Ding Proc Natl Acad Sci U S A. 2006 November 14; 103(46): 17266–17271. Published online 2006 November 6. doi: 10.1073/pnas.0608156103.PMCID: PMC1859921 AMP-activated protein kinase regulates the assembly of epithelial tight junctions Li Zhang, Ji Li, Lawrence H. Young, and Michael J. Caplan Proc Natl Acad Sci U S A. 2006 November 14; 103(46): 17272–17277. Published online 2006 November 6. doi: 10.1073/pnas.0608531103.PMCID: PMC1859922 Wilms' tumor 1-associating protein regulates G2/M transition through stabilization of cyclin A2 mRNA Keiko Horiuchi, Michihisa Umetani, Takashi Minami, Hiroto Okayama, Shinji Takada, Masayuki Yamamoto, Hiroyuki Aburatani, Patrick C. Reid, David E. Housman, Takao Hamakubo, and Tatsuhiko Kodama Proc Natl Acad Sci U S A. 2006 November 14; 103(46): 17278–17283. Published online 2006 November 6. doi: 10.1073/pnas.0608357103.PMCID: PMC1634838 Developmental Biology A subunit of the mediator complex regulates vertebrate neuronal development Xiaoqun Wang, Nan Yang, Etsuko Uno, Robert G. Roeder, and Su Guo Proc Natl Acad Sci U S A. 2006 November 14; 103(46): 17284–17289. Published online 2006 November 6. doi: 10.1073/pnas.0605414103.PMCID: PMC1859923 Evolution Bacterial metapopulations in nanofabricated landscapes Juan E. Keymer, Peter Galajda, Cecilia Muldoon, Sungsu Park, and Robert H. Austin Proc Natl Acad Sci U S A. 2006 November 14; 103(46): 17290–17295. Published online 2006 November 7. doi: 10.1073/pnas.0607971103.PMCID: PMC1635019 A proboscidean from the late Oligocene of Eritrea, a “missing link” between early Elephantiformes and Elephantimorpha, and biogeographic implications Jeheskel Shoshani, Robert C. Walter, Michael Abraha, Seife Berhe, Pascal Tassy, William J. Sanders, Gary H. Marchant, Yosief Libsekal, Tesfalidet Ghirmai, and Dietmar Zinner Proc Natl Acad Sci U S A. 2006 November 14; 103(46): 17296–17301. Published online 2006 November 3. doi: 10.1073/pnas.0603689103.PMCID: PMC1859925 Rapidly evolving zona pellucida domain proteins are a major component of the vitelline envelope of abalone eggs Jan E. Aagaard, Xianhua Yi, Michael J. MacCoss, and Willie J. Swanson Proc Natl Acad Sci U S A. 2006 November 14; 103(46): 17302–17307. Published online 2006 November 3. doi: 10.1073/pnas.0603125103.PMCID: PMC1859926 Cognitive cladistics and cultural override in Hominid spatial cognition Daniel B. M. Haun, Christian J. Rapold, Josep Call, Gabriele Janzen, and Stephen C. Levinson Proc Natl Acad Sci U S A. 2006 November 14; 103(46): 17568–17573. Published online 2006 November 1. doi: 10.1073/pnas.0607999103.PMCID: PMC1859970 Genetics From the Cover: Germ-line epigenetic modification of the murine Avy allele by nutritional supplementation Jennifer E. Cropley, Catherine M. Suter, Kenneth B. Beckman, and David I. K. Martin Proc Natl Acad Sci U S A. 2006 November 14; 103(46): 17308–17312. Published online 2006 November 13. doi: 10.1073/pnas.0607090103.PMCID: PMC1838538 Veela defines a molecular link between Cryptochrome and Timeless in the light-input pathway to Drosophila's circadian clock Nicolai Peschel, Shobi Veleri, and Ralf Stanewsky Proc Natl Acad Sci U S A. 2006 November 14; 103(46): 17313–17318. Published online 2006 October 26. doi: 10.1073/pnas.0606675103.PMCID: PMC1859927 Multiple pathways of selected gene amplification during adaptive mutation Elisabeth Kugelberg, Eric Kofoid, Andrew B. Reams, Dan I. Andersson, and John R. Roth Proc Natl Acad Sci U S A. 2006 November 14; 103(46): 17319–17324. Published online 2006 November 2. doi: 10.1073/pnas.0608309103.PMCID: PMC1633709 DNA nucleotide excision repair-dependent signaling to checkpoint activation Federica Marini, Tiziana Nardo, Michele Giannattasio, Mario Minuzzo, Miria Stefanini, Paolo Plevani, and Marco Muzi Falconi Proc Natl Acad Sci U S A. 2006 November 14; 103(46): 17325–17330. Published online 2006 November 6. doi: 10.1073/pnas.0605446103.PMCID: PMC1859929 Telomere-mediated chromosomal truncation in maize Weichang Yu, Jonathan C. Lamb, Fangpu Han, and James A. Birchler Proc Natl Acad Sci U S A. 2006 November 14; 103(46): 17331–17336. Published online 2006 November 3. doi: 10.1073/pnas.0605750103.PMCID: PMC1859930 Small dsRNAs induce transcriptional activation in human cells Long-Cheng Li, Steven T. Okino, Hong Zhao, Deepa Pookot, Robert F. Place, Shinji Urakami, Hideki Enokida, and Rajvir Dahiya Proc Natl Acad Sci U S A. 2006 November 14; 103(46): 17337–17342. Published online 2006 November 3. doi: 10.1073/pnas.0607015103.PMCID: PMC1859931 Immunology Dual recognition of herpes simplex viruses by TLR2 and TLR9 in dendritic cells Ayuko Sato, Melissa M. Linehan, and Akiko Iwasaki Proc Natl Acad Sci U S A. 2006 November 14; 103(46): 17343–17348. Published online 2006 November 3. doi: 10.1073/pnas.0605102103.PMCID: PMC1859932 Hexim1 sequesters positive transcription elongation factor b from the class II transactivator on MHC class II promoters Jiri Kohoutek, Dalibor Blazek, and B. Matija Peterlin Proc Natl Acad Sci U S A. 2006 November 14; 103(46): 17349–17354. Published online 2006 November 6. doi: 10.1073/pnas.0603079103.PMCID: PMC1859933 Medical Sciences Genotypic predictors of human immunodeficiency virus type 1 drug resistance Soo-Yon Rhee, Jonathan Taylor, Gauhar Wadhera, Asa Ben-Hur, Douglas L. Brutlag, and Robert W. Shafer Proc Natl Acad Sci U S A. 2006 November 14; 103(46): 17355–17360. Published online 2006 October 25. doi: 10.1073/pnas.0607274103.PMCID: PMC1622926 uPAR and HER-2 gene status in individual breast cancer cells from blood and tissues Songdong Meng, Debu Tripathy, Sanjay Shete, Raheela Ashfaq, Hossein Saboorian, Barbara Haley, Eugene Frenkel, David Euhus, Marilyn Leitch, Cynthia Osborne, Edward Clifford, Steve Perkins, Peter Beitsch, Amanullah Khan, Larry Morrison, Dorothee Herlyn, Leon W. M. M. Terstappen, Nancy Lane, Jianqiang Wang, and Jonathan Uhr Proc Natl Acad Sci U S A. 2006 November 14; 103(46): 17361–17365. Published online 2006 November 1. doi: 10.1073/pnas.0608113103.PMCID: PMC1838539 Apoptosis in retinal degeneration involves cross-talk between apoptosis-inducing factor (AIF) and caspase-12 and is blocked by calpain inhibitors Daniela Sanges, Antonella Comitato, Roberta Tammaro, and Valeria Marigo Proc Natl Acad Sci U S A. 2006 November 14; 103(46): 17366–17371. Published online 2006 November 6. doi: 10.1073/pnas.0606276103.PMCID: PMC1859935 Gene transfer in humans using a conditionally replicating lentiviral vector Bruce L. Levine, Laurent M. Humeau, Jean Boyer, Rob-Roy MacGregor, Tessio Rebello, Xiaobin Lu, Gwendolyn K. Binder, Vladimir Slepushkin, Franck Lemiale, John R. Mascola, Frederic D. Bushman, Boro Dropulic, and Carl H. June Proc Natl Acad Sci U S A. 2006 November 14; 103(46): 17372–17377. Published online 2006 November 7. doi: 10.1073/pnas.0608138103.PMCID: PMC1635018 A pivotal role for endogenous TGF-β-activated kinase-1 in the LKB1/AMP-activated protein kinase energy-sensor pathway Min Xie, Dou Zhang, Jason R. B. Dyck, Yi Li, Hui Zhang, Masae Morishima, Douglas L. Mann, George E. Taffet, Antonio Baldini, Dirar S. Khoury, and Michael D. Schneider Proc Natl Acad Sci U S A. 2006 November 14; 103(46): 17378–17383. Published online 2006 November 3. doi: 10.1073/pnas.0604708103.PMCID: PMC1859937 Sphingosine-1-phosphate lyase potentiates apoptosis via p53- and p38-dependent pathways and is down-regulated in colon cancer Babak Oskouian, Prathap Sooriyakumaran, Alexander D. Borowsky, Angelina Crans, Lisa Dillard-Telm, Yuen Yee Tam, Padmavathi Bandhuvula, and Julie D. Saba Proc Natl Acad Sci U S A. 2006 November 14; 103(46): 17384–17389. Published online 2006 November 7. doi: 10.1073/pnas.0600050103.PMCID: PMC1859938 Astrocyte elevated gene-1 (AEG-1) is a target gene of oncogenic Ha-ras requiring phosphatidylinositol 3-kinase and c-Myc Seok-Geun Lee, Zao-Zhong Su, Luni Emdad, Devanand Sarkar, and Paul B. Fisher Proc Natl Acad Sci U S A. 2006 November 14; 103(46): 17390–17395. Published online 2006 November 6. doi: 10.1073/pnas.0608386103.PMCID: PMC1859939 Introduction of oncogenes into mammary glands in vivo with an avian retroviral vector initiates and promotes carcinogenesis in mouse models Zhijun Du, Katrina Podsypanina, Shixia Huang, Amanda McGrath, Michael J. Toneff, Ekaterina Bogoslovskaia, Xiaomei Zhang, Ricardo C. Moraes, Michele Fluck, D. Craig Allred, Michael T. Lewis, Harold E. Varmus, and Yi Li Proc Natl Acad Sci U S A. 2006 November 14; 103(46): 17396–17401. Published online 2006 November 7. doi: 10.1073/pnas.0608607103.PMCID: PMC1635021 Analysis of oncogenic signaling networks in glioblastoma identifies ASPM as a molecular target S. Horvath, B. Zhang, M. Carlson, K. V. Lu, S. Zhu, R. M. Felciano, M. F. Laurance, W. Zhao, S. Qi, Z. Chen, Y. Lee, A. C. Scheck, L. M. Liau, H. Wu, D. H. Geschwind, P. G. Febbo, H. I. Kornblum, T. F. Cloughesy, S. F. Nelson, and P. S. Mischel Proc Natl Acad Sci U S A. 2006 November 14; 103(46): 17402–17407. Published online 2006 November 7. doi: 10.1073/pnas.0608396103.PMCID: PMC1635024 Development of 17-allylamino-17-demethoxygeldanamycin hydroquinone hydrochloride (IPI-504), an anti-cancer agent directed against Hsp90 Jens R. Sydor, Emmanuel Normant, Christine S. Pien, James R. Porter, Jie Ge, Louis Grenier, Roger H. Pak, Janid A. Ali, Marlene S. Dembski, Jebecka Hudak, Jon Patterson, Courtney Penders, Melissa Pink, Margaret A. Read, Jim Sang, Caroline Woodward, Yilong Zhang, David S. Grayzel, Jim Wright, John A. Barrett, Vito J. Palombella, Julian Adams, and Jeffrey K. Tong Proc Natl Acad Sci U S A. 2006 November 14; 103(46): 17408–17413. Published online 2006 November 7. doi: 10.1073/pnas.0608372103.PMCID: PMC1635022 Kv1.3 channels are a therapeutic target for T cell-mediated autoimmune diseases Christine Beeton, Heike Wulff, Nathan E. Standifer, Philippe Azam, Katherine M. Mullen, Michael W. Pennington, Aaron Kolski-Andreaco, Eric Wei, Alexandra Grino, Debra R. Counts, Ping H. Wang, Christine J. LeeHealey, Brian S. Andrews, Ananthakrishnan Sankaranarayanan, Daniel Homerick, Werner W. Roeck, Jamshid Tehranzadeh, Kimber L. Stanhope, Pavel Zimin, Peter J. Havel, Stephen Griffey, Hans-Guenther Knaus, Gerald T. Nepom, George A. Gutman, Peter A. Calabresi, and K. George Chandy Proc Natl Acad Sci U S A. 2006 November 14; 103(46): 17414–17419. Published online 2006 November 6. doi: 10.1073/pnas.0605136103.PMCID: PMC1859943 Cis-urocanic acid, a sunlight-induced immunosuppressive factor, activates immune suppression via the 5-HT2A receptor Jeffrey P. Walterscheid, Dat X. Nghiem, Nasser Kazimi, Leta K. Nutt, David J. McConkey, Mary Norval, and Stephen E. Ullrich Proc Natl Acad Sci U S A. 2006 November 14; 103(46): 17420–17425. Published online 2006 November 3. doi: 10.1073/pnas.0603119103.PMCID: PMC1859944 Mullerian Inhibiting Substance enhances subclinical doses of chemotherapeutic agents to inhibit human and mouse ovarian cancer Rafael Pieretti-Vanmarcke, Patricia K. Donahoe, Lisa A. Pearsall, Daniela M. Dinulescu, Denise C. Connolly, Elkan F. Halpern, Michael V. Seiden, and David T. MacLaughlin Proc Natl Acad Sci U S A. 2006 November 14; 103(46): 17426–17431. Published online 2006 November 6. doi: 10.1073/pnas.0607959103.PMCID: PMC1859945 An essential role of NF-κB in the “tumor-like” phenotype of arthritic synoviocytes Xiangli Li and Sergei S. Makarov Proc Natl Acad Sci U S A. 2006 November 14; 103(46): 17432–17437. Published online 2006 November 6. doi: 10.1073/pnas.0607939103.PMCID: PMC1859946 Multipotent stromal cells from human marrow home to and promote repair of pancreatic islets and renal glomeruli in diabetic NOD/scid mice Ryang Hwa Lee, Min Jeong Seo, Roxanne L. Reger, Jeffrey L. Spees, Andrey A. Pulin, Scott D. Olson, and Darwin J. Prockop Proc Natl Acad Sci U S A. 2006 November 14; 103(46): 17438–17443. Published online 2006 November 6. doi: 10.1073/pnas.0608249103.PMCID: PMC1634835 Correlation between β cell mass and glycemic control in type 1 diabetic recipients of islet cell graft Bart Keymeulen, Pieter Gillard, Chantal Mathieu, Babak Movahedi, Geert Maleux, Georges Delvaux, Dirk Ysebaert, Bart Roep, Evy Vandemeulebroucke, Miriam Marichal, Peter In 't Veld, Marika Bogdani, Christel Hendrieckx, Frans Gorus, Zhidong Ling, Jon van Rood, and Daniel Pipeleers Proc Natl Acad Sci U S A. 2006 November 14; 103(46): 17444–17449. Published online 2006 November 7. doi: 10.1073/pnas.0608141103.PMCID: PMC1859948 Angiopoietin-like protein 4 converts lipoprotein lipase to inactive monomers and modulates lipase activity in adipose tissue Valentina Sukonina, Aivar Lookene, Thomas Olivecrona, and Gunilla Olivecrona Proc Natl Acad Sci U S A. 2006 November 14; 103(46): 17450–17455. Published online 2006 November 6. doi: 10.1073/pnas.0604026103.PMCID: PMC1859949 Individuals homozygous for the age-related macular degeneration risk-conferring variant of complement factor H have elevated levels of CRP in the choroid P. T. Johnson, K. E. Betts, M. J. Radeke, G. S. Hageman, D. H. Anderson, and L. V. Johnson Proc Natl Acad Sci U S A. 2006 November 14; 103(46): 17456–17461. Published online 2006 November 1. doi: 10.1073/pnas.0606234103.PMCID: PMC1859950 Microbiology Combinatorial biosynthesis of novel antibiotics related to daptomycin Kien T. Nguyen, Daniel Ritz, Jian-Qiao Gu, Dylan Alexander, Min Chu, Vivian Miao, Paul Brian, and Richard H. Baltz Proc Natl Acad Sci U S A. 2006 November 14; 103(46): 17462–17467. Published online 2006 November 7. doi: 10.1073/pnas.0608589103.PMCID: PMC1859951 Quinone sensing by the circadian input kinase of the cyanobacterial circadian clock Natalia B. Ivleva, Tiyu Gao, Andy C. LiWang, and Susan S. Golden Proc Natl Acad Sci U S A. 2006 November 14; 103(46): 17468–17473. Published online 2006 November 6. doi: 10.1073/pnas.0606639103.PMCID: PMC1859952 An escort mechanism for cycling of export chaperones during flagellum assembly Lewis D. B. Evans, Graham P. Stafford, Sangita Ahmed, Gillian M. Fraser, and Colin Hughes Proc Natl Acad Sci U S A. 2006 November 14; 103(46): 17474–17479. Published online 2006 November 6. doi: 10.1073/pnas.0605197103.PMCID: PMC1859953 Systems approach to refining genome annotation Jennifer L. Reed, Trina R. Patel, Keri H. Chen, Andrew R. Joyce, Margaret K. Applebee, Christopher D. Herring, Olivia T. Bui, Eric M. Knight, Stephen S. Fong, and Bernhard O. Palsson Proc Natl Acad Sci U S A. 2006 November 14; 103(46): 17480–17484. Published online 2006 November 6. doi: 10.1073/pnas.0603364103.PMCID: PMC1859954 Biogenesis of actin-like bacterial cytoskeletal filaments destined for positioning prokaryotic magnetic organelles Nathalie Pradel, Claire-Lise Santini, Alain Bernadac, Yoshihiro Fukumori, and Long-Fei Wu Proc Natl Acad Sci U S A. 2006 November 14; 103(46): 17485–17489. Published online 2006 November 3. doi: 10.1073/pnas.0603760103.PMCID: PMC1859955 Neuroscience Unequal representation of cardinal vs. oblique orientations in the middle temporal visual area Xiangmin Xu, Christine E. Collins, Ilya Khaytin, Jon H. Kaas, and Vivien A. Casagrande Proc Natl Acad Sci U S A. 2006 November 14; 103(46): 17490–17495. Published online 2006 November 6. doi: 10.1073/pnas.0608502103.PMCID: PMC1859956 The Drosophila radish gene encodes a protein required for anesthesia-resistant memory Elisabeth Folkers, Scott Waddell, and William G. Quinn Proc Natl Acad Sci U S A. 2006 November 14; 103(46): 17496–17500. Published online 2006 November 6. doi: 10.1073/pnas.0608377103.PMCID: PMC1634833 Ablation of hippocampal neurogenesis impairs contextual fear conditioning and synaptic plasticity in the dentate gyrus Michael D. Saxe, Fortunato Battaglia, Jing-Wen Wang, Gael Malleret, Denis J. David, James E. Monckton, A. Denise R. Garcia, Michael V. Sofroniew, Eric R. Kandel, Luca Santarelli, René Hen, and Michael R. Drew Proc Natl Acad Sci U S A. 2006 November 14; 103(46): 17501–17506. Published online 2006 November 6. doi: 10.1073/pnas.0607207103.PMCID: PMC1859958 Local field potential reflects perceptual suppression in monkey visual cortex Melanie Wilke, Nikos K. Logothetis, and David A. Leopold Proc Natl Acad Sci U S A. 2006 November 14; 103(46): 17507–17512. Published online 2006 November 6. doi: 10.1073/pnas.0604673103.PMCID: PMC1859959 Redefining the concept of reactive astrocytes as cells that remain within their unique domains upon reaction to injury Ulrika Wilhelmsson, Eric A. Bushong, Diana L. Price, Benjamin L. Smarr, Van Phung, Masako Terada, Mark H. Ellisman, and Milos Pekny Proc Natl Acad Sci U S A. 2006 November 14; 103(46): 17513–17518. Published online 2006 November 7. doi: 10.1073/pnas.0602841103.PMCID: PMC1859960 Learning and memory associated with aggression in Drosophila melanogaster Alexandra Yurkovic, Oulu Wang, Alo C. Basu, and Edward A. Kravitz Proc Natl Acad Sci U S A. 2006 November 14; 103(46): 17519–17524. Published online 2006 November 6. doi: 10.1073/pnas.0608211103.PMCID: PMC1634832 Structural and functional MRI reveals multiple retinal layers Haiying Cheng, Govind Nair, Tiffany A. Walker, Moon K. Kim, Machelle T. Pardue, Peter M. Thulé, Darin E. Olson, and Timothy Q. Duong Proc Natl Acad Sci U S A. 2006 November 14; 103(46): 17525–17530. Published online 2006 November 6. doi: 10.1073/pnas.0605790103.PMCID: PMC1859962 Pharmacology Carbamylated erythropoietin ameliorates the metabolic stress induced in vivo by severe chronic hypoxia Monica Fantacci, Paola Bianciardi, Anna Caretti, Thomas R. Coleman, Anthony Cerami, Michael Brines, and Michele Samaja Proc Natl Acad Sci U S A. 2006 November 14; 103(46): 17531–17536. Published online 2006 November 7. doi: 10.1073/pnas.0608814103.PMCID: PMC1859963 Identification of the α2-δ-1 subunit of voltage-dependent calcium channels as a molecular target for pain mediating the analgesic actions of pregabalin Mark J. Field, Peter J. Cox, Emma Stott, Heather Melrose, James Offord, Ti-Zhi Su, Steve Bramwell, Laura Corradini, Steven England, Joanna Winks, Ross A. Kinloch, Jan Hendrich, Annette C. Dolphin, Tony Webb, and Dic Williams Proc Natl Acad Sci U S A. 2006 November 14; 103(46): 17537–17542. Published online 2006 November 6. doi: 10.1073/pnas.0409066103.PMCID: PMC1859964 Physiology An exceptionally fast actomyosin reaction powers insect flight muscle Douglas M. Swank, Vivek K. Vishnudas, and David W. Maughan Proc Natl Acad Sci U S A. 2006 November 14; 103(46): 17543–17547. Published online 2006 November 3. doi: 10.1073/pnas.0604972103.PMCID: PMC1859965 SK channels mediate NADPH oxidase-independent reactive oxygen species production and apoptosis in granulocytes Alex J. Fay, Xiang Qian, Yuh Nung Jan, and Lily Yeh Jan Proc Natl Acad Sci U S A. 2006 November 14; 103(46): 17548–17553. Published online 2006 November 3. doi: 10.1073/pnas.0607914103.PMCID: PMC1634413 Plant Biology The protective role of silicon in the Arabidopsis–powdery mildew pathosystem François Fauteux, Florian Chain, François Belzile, James G. Menzies, and Richard R. Bélanger Proc Natl Acad Sci U S A. 2006 November 14; 103(46): 17554–17559. Published online 2006 November 2. doi: 10.1073/pnas.0606330103.PMCID: PMC1859967 Population Biology Source reduction of mosquito larval habitats has unexpected consequences on malaria transmission Weidong Gu, James L. Regens, John C. Beier, and Robert J. Novak Proc Natl Acad Sci U S A. 2006 November 14; 103(46): 17560–17563. Published online 2006 November 3. doi: 10.1073/pnas.0608452103.PMCID: PMC1634411 Psychology Evidence for large long-term memory capacities in baboons and pigeons and its implications for learning and the evolution of cognition Joël Fagot and Robert G. Cook Proc Natl Acad Sci U S A. 2006 November 14; 103(46): 17564–17567. Published online 2006 November 6. doi: 10.1073/pnas.0605184103.PMCID: PMC1634836 Social Sciences Psychology Cognitive cladistics and cultural override in Hominid spatial cognition Daniel B. M. Haun, Christian J. Rapold, Josep Call, Gabriele Janzen, and Stephen C. Levinson Proc Natl Acad Sci U S A. 2006 November 14; 103(46): 17568–17573. Published online 2006 November 1. doi: 10.1073/pnas.0607999103.PMCID: PMC1859970 Sustainability Science Returning forests analyzed with the forest identity Pekka E. Kauppi, Jesse H. Ausubel, Jingyun Fang, Alexander S. Mather, Roger A. Sedjo, and Paul E. Waggoner Proc Natl Acad Sci U S A. 2006 November 14; 103(46): 17574–17579. Published online 2006 November 13. doi: 10.1073/pnas.0608343103.PMCID: PMC1635979 Cell Biology Correction for Ceppi et al., Two tail-anchored protein variants, differing in transmembrane domain length and intracellular sorting, interact differently with lipids Proc Natl Acad Sci U S A. 2006 November 14; 103(46): 17580. Published online 2006 November 6. doi: 10.1073/pnas.0608601103.PMCID: PMC1859972 Corrects: Paolo Ceppi, et al. Two tail-anchored protein variants, differing in transmembrane domain length and intracellular sorting, interact differently with lipids. Proc Natl Acad Sci U S A. 2005 November 8; 102(45): 16269–16274. |