| | This journal provides immediate access to some articles. This Week in PNAS Proc Natl Acad Sci U S A. 2006 October 10; 103(41): 14979–14980. doi: 10.1073/iti4106103.PMCID: PMC1622764 Commentaries The piggyBac transposon holds promise for human gene therapy Cédric Feschotte PMCID: PMC1622765 Of mice and sperm Tommaso Pizzari PMCID: PMC1622766 Functional units in the olfactory system Michael Leon and Brett Johnson PMCID: PMC1622767 Physical Sciences Chemistry A nucleobase lesion remodels the interaction of its normal neighbor in a DNA glycosylase complex Anirban Banerjee and Gregory L. Verdine PMCID: PMC1622772 Physics Conditions for extreme sensitivity of protein diffusion in membranes to cell environments Yaroslav Tserkovnyak and David R. Nelson PMCID: PMC1622770 Biological Sciences Applied Biological Sciences From the Cover:
piggyBac is a flexible and highly active transposon as compared to Sleeping Beauty, Tol2, and Mos1 in mammalian cells Sareina Chiung-Yuan Wu, Yaa-Jyuhn James Meir, Craig J. Coates, Alfred M. Handler, Pawel Pelczar, Stefan Moisyadi, and Joseph M. Kaminski PMCID: PMC1622771 A retrovirus-based protein complementation assay screen reveals functional AKT1-binding partners Zhiyong Ding, Jiyong Liang, Yiling Lu, Qinghua Yu, Zhou Songyang, Shiaw-Yih Lin, and Gordon B. Mills PMCID: PMC1636760 Biochemistry A nucleobase lesion remodels the interaction of its normal neighbor in a DNA glycosylase complex Anirban Banerjee and Gregory L. Verdine PMCID: PMC1622772 The structure of human ADP-ribosylhydrolase 3 (ARH3) provides insights into the reversibility of protein ADP-ribosylation Christoph Mueller-Dieckmann, Stefan Kernstock, Michael Lisurek, Jens Peter von Kries, Friedrich Haag, Manfred S. Weiss, and Friedrich Koch-Nolte PMCID: PMC1622773 Crystal structure of a substrate complex of myo-inositol oxygenase, a di-iron oxygenase with a key role in inositol metabolism Peter M. Brown, Tom T. Caradoc-Davies, James M. J. Dickson, Garth J. S. Cooper, Kerry M. Loomes, and Edward N. Baker PMCID: PMC1622774 Selective fluorescent imaging of superoxide in vivo using ethidium-based probes Kristine M. Robinson, Michael S. Janes, Mariana Pehar, Jeffrey S. Monette, Meredith F. Ross, Tory M. Hagen, Michael P. Murphy, and Joseph S. Beckman PMCID: PMC1586181 Protein kinase A regulates RNA polymerase III transcription through the nuclear localization of Maf1 Robyn D. Moir, JaeHoon Lee, Rebecca A. Haeusler, Neelam Desai, David R. Engelke, and Ian M. Willis PMCID: PMC1622776 Biophysics Conditions for extreme sensitivity of protein diffusion in membranes to cell environments Yaroslav Tserkovnyak and David R. Nelson PMCID: PMC1622770 Ultrafast infrared spectroscopy reveals a key step for successful entry into the photocycle for photoactive yellow protein L. J. G. W. van Wilderen, M. A. van der Horst, I. H. M. van Stokkum, K. J. Hellingwerf, R. van Grondelle, and M. L. Groot PMCID: PMC1940041 From the Cover:
Structural basis for understanding oncogenic p53 mutations and designing rescue drugs Andreas C. Joerger, Hwee Ching Ang, and Alan R. Fersht PMCID: PMC1635156 NMR structural and kinetic characterization of a homeodomain diffusing and hopping on nonspecific DNA Junji Iwahara, Markus Zweckstetter, and G. Marius Clore PMCID: PMC1622777 Direct observation of Bin/amphiphysin/Rvs (BAR) domain-induced membrane curvature by means of molecular dynamics simulations Philip D. Blood and Gregory A. Voth PMCID: PMC1622778 Cell Biology A role for WRN in telomere-based DNA damage responses Mark S. Eller, Xiaodong Liao, SuiYang Liu, Kendra Hanna, Helena Bäckvall, Patricia L. Opresko, Vilhelm A. Bohr, and Barbara A. Gilchrest PMCID: PMC1586178 Casein kinase 2 (CK2) increases survivin expression via enhanced β-catenin–T cell factor/lymphoid enhancer binding factor-dependent transcription J. C. Tapia, V. A. Torres, D. A. Rodriguez, L. Leyton, and A. F. G. Quest PMCID: PMC1622780 Androgen receptor as a licensing factor for DNA replication in androgen-sensitive prostate cancer cells Ivan V. Litvinov, Donald J. Vander Griend, Lizamma Antony, Susan Dalrymple, Angelo M. De Marzo, Charles G. Drake, and John T. Isaacs PMCID: PMC1622781 DJ-1, a cancer- and Parkinson's disease-associated protein, stabilizes the antioxidant transcriptional master regulator Nrf2 Casey M. Clements, Richard S. McNally, Brian J. Conti, Tak W. Mak, and Jenny P.-Y. Ting PMCID: PMC1586179 Molecular analysis of mitotic chromosome condensation using a quantitative time-resolved fluorescence microscopy assay Paul S. Maddox, Nathan Portier, Arshad Desai, and Karen Oegema PMCID: PMC1622782 Developmental Biology Interdigital webbing retention in bat wings illustrates genetic changes underlying amniote limb diversification Scott D. Weatherbee, Richard R. Behringer, John J. Rasweiler, IV, and Lee A. Niswander PMCID: PMC1622783 The GLD-2 poly(A) polymerase activates gld-1 mRNA in the Caenorhabditis elegans germ line Nayoung Suh, Britta Jedamzik, Christian R. Eckmann, Marvin Wickens, and Judith Kimble PMCID: PMC1622784 Evolution From the Cover:
Sperm competition enhances functional capacity of mammalian spermatozoa Montserrat Gomendio, Juan Martin-Coello, Cristina Crespo, Concepción Magaña, and Eduardo R. S. Roldan PMCID: PMC1570616 The history of early bee diversification based on five genes plus morphology Bryan N. Danforth, Sedonia Sipes, Jennifer Fang, and Seán G. Brady PMCID: PMC1586180 Genetics INAUGURAL ARTICLE by a Recently Elected Academy Member: wasted away, a Drosophila mutation in triosephosphate isomerase, causes paralysis, neurodegeneration, and early death Joshua P. Gnerer, Robert A. Kreber, and Barry Ganetzky PMCID: PMC1581428 Phosphodiesterase genes are associated with susceptibility to major depression and antidepressant treatment response Ma-Li Wong, Fiona Whelan, Panagiotis Deloukas, Pamela Whittaker, Marcos Delgado, Rita M. Cantor, Samuel M. McCann, and Julio Licinio PMCID: PMC1581426 Immunology Generation of heavy-chain-only antibodies in mice Rick Janssens, Sylvia Dekker, Rudi W. Hendriks, George Panayotou, Alexandra van Remoortere, John Kong-a San, Frank Grosveld, and Dubravka Drabek PMCID: PMC1586177 Evidence for licensing of IFN-γ-induced IFN regulatory factor 1 transcription factor by MyD88 in Toll-like receptor-dependent gene induction program Hideo Negishi, Yasuyuki Fujita, Hideyuki Yanai, Shinya Sakaguchi, Xinshou Ouyang, Masahiro Shinohara, Hiroshi Takayanagi, Yusuke Ohba, Tadatsugu Taniguchi, and Kenya Honda PMCID: PMC1586247 CD8+ regulatory T cells generated by neonatal recognition of peripheral self-antigen Roland Reibke, Natalio Garbi, Ruth Ganss, Günter J. Hämmerling, Bernd Arnold, and Thilo Oelert PMCID: PMC1622790 Medical Sciences Mitochondria-related male infertility Kazuto Nakada, Akitsugu Sato, Kayo Yoshida, Takashi Morita, Hiromitsu Tanaka, Shin-Ichi Inoue, Hiromichi Yonekawa, and Jun-Ichi Hayashi PMCID: PMC1622791 A purified Bacillus thuringiensis crystal protein with therapeutic activity against the hookworm parasite Ancylostoma ceylanicum Michael Cappello, Richard D. Bungiro, Lisa M. Harrison, Larry J. Bischof, Joel S. Griffitts, Brad D. Barrows, and Raffi V. Aroian PMCID: PMC1622792 The HIV Env variant N283 enhances macrophage tropism and is associated with brain infection and dementia Rebecca L. Dunfee, Elaine R. Thomas, Paul R. Gorry, Jianbin Wang, Joann Taylor, Kevin Kunstman, Steven M. Wolinsky, and Dana Gabuzda PMCID: PMC1586182 TEL-AML1 transgenic zebrafish model of precursor B cell acute lymphoblastic leukemia Hatem E. Sabaawy, Mizuki Azuma, Lisa J. Embree, Huai-Jen Tsai, Matthew F. Starost, and Dennis D. Hickstein PMCID: PMC1622794 Enzyme therapy in mannose receptor-null mucopolysaccharidosis VII mice defines roles for the mannose 6-phosphate and mannose receptors William S. Sly, Carole Vogler, Jeffrey H. Grubb, Beth Levy, Nancy Galvin, Yun Tan, Tatsuo Nishioka, and Shunji Tomatsu PMCID: PMC1622795 Allosteric inhibition of Staphylococcus aureus d-alanine:d-alanine ligase revealed by crystallographic studies Shenping Liu, Jeanne S. Chang, John T. Herberg, Miao-Miao Horng, Paul K. Tomich, Alice H. Lin, and Keith R. Marotti PMCID: PMC1622796 The omega-3 fatty acid docosahexaenoate attenuates endothelial cyclooxygenase-2 induction through both NADP(H) oxidase and PKCε inhibition Marika Massaro, Aida Habib, Laura Lubrano, Serena Del Turco, Guido Lazzerini, Todd Bourcier, Babette B. Weksler, and Raffaele De Caterina PMCID: PMC1622797 Microbiology Nucleolar trafficking is essential for nuclear export of intronless herpesvirus mRNA James R. Boyne and Adrian Whitehouse PMCID: PMC1622798 Midgut bacteria required for Bacillus thuringiensis insecticidal activity Nichole A. Broderick, Kenneth F. Raffa, and Jo Handelsman PMCID: PMC1622799 Evolution of sensory complexity recorded in a myxobacterial genome B. S. Goldman, W. C. Nierman, D. Kaiser, S. C. Slater, A. S. Durkin, J. A. Eisen, C. M. Ronning, W. B. Barbazuk, M. Blanchard, C. Field, C. Halling, G. Hinkle, O. Iartchuk, H. S. Kim, C. Mackenzie, R. Madupu, N. Miller, A. Shvartsbeyn, S. A. Sullivan, M. Vaudin, R. Wiegand, and H. B. Kaplan PMCID: PMC1622800 Neuroscience From the Cover:
Separate encoding of identity and similarity of complex familiar odors in piriform cortex Mikiko Kadohisa and Donald A. Wilson PMCID: PMC1622801 A molecular neuroethological approach for identifying and characterizing a cascade of behaviorally regulated genes Kazuhiro Wada, Jason T. Howard, Patrick McConnell, Osceola Whitney, Thierry Lints, Miriam V. Rivas, Haruhito Horita, Michael A. Patterson, Stephanie A. White, Constance Scharff, Sebastian Haesler, Shengli Zhao, Hironobu Sakaguchi, Masatoshi Hagiwara, Toshiyuki Shiraki, Tomoko Hirozane-Kishikawa, Pate Skene, Yoshihide Hayashizaki, Piero Carninci, and Erich D. Jarvis PMCID: PMC1622802 Synaptically released zinc gates long-term potentiation in fear conditioning pathways Sodikdjon A. Kodirov, Shuichi Takizawa, Jamie Joseph, Eric R. Kandel, Gleb P. Shumyatsky, and Vadim Y. Bolshakov PMCID: PMC1622803 Operant matching is a generic outcome of synaptic plasticity based on the covariance between reward and neural activity Yonatan Loewenstein and H. Sebastian Seung PMCID: PMC1622804 GABAA receptor α4 subunits mediate extrasynaptic inhibition in thalamus and dentate gyrus and the action of gaboxadol D. Chandra, F. Jia, J. Liang, Z. Peng, A. Suryanarayanan, D. F. Werner, I. Spigelman, C. R. Houser, R. W. Olsen, N. L. Harrison, and G. E. Homanics PMCID: PMC1578762 Variation at the rat Crhr1 locus and sensitivity to relapse into alcohol seeking induced by environmental stress A. C. Hansson, A. Cippitelli, W. H. Sommer, A. Fedeli, K. Björk, L. Soverchia, A. Terasmaa, M. Massi, M. Heilig, and R. Ciccocioppo PMCID: PMC1622806 Slow progressive degeneration of nigral dopaminergic neurons in postnatal Engrailed mutant mice Paola Sgadò, Lavinia Albéri, Daniel Gherbassi, Sherri L. Galasso, Geert M. J. Ramakers, Kambiz N. Alavian, Marten P. Smidt, Richard H. Dyck, and Horst H. Simon PMCID: PMC1622807 Activation, internalization, and recycling of the serotonin 2A receptor by dopamine Samarjit Bhattacharyya, Ishier Raote, Aditi Bhattacharya, Ricardo Miledi, and Mitradas M. Panicker PMCID: PMC1622808 From the Cover:
Disrupted motor learning and long-term synaptic plasticity in mice lacking NMDAR1 in the striatum Mai T. Dang, Fumiaki Yokoi, Henry H. Yin, David M. Lovinger, Yanyan Wang, and Yuqing Li PMCID: PMC1622809 Physiology Neuropathy target esterase catalyzes osmoprotective renal synthesis of glycerophosphocholine in response to high NaCl Morgan Gallazzini, Joan D. Ferraris, Margarita Kunin, Ryan G. Morris, and Maurice B. Burg PMCID: PMC1622810 Plant Biology INAUGURAL ARTICLE by a Recently Elected Academy Member: Defective RNA processing enhances RNA silencing and influences flowering of ArabidopsisAlan J. Herr, Attila Molnàr, Alex Jones, and David C. Baulcombe PMCID: PMC1581427 Population Biology Detecting emerging strains of tuberculosis by using spoligotypes Mark M. Tanaka and Andrew R. Francis PMCID: PMC1622811 Corrections Correction for Naccache et al., Binding of internalized receptors to the PDZ domain of GIPC/synectin recruits myosin VI to endocytic vesicles PMCID: PMC1622812 Corrects: Samia N. Naccache, et al. Binding of internalized receptors to the PDZ domain of GIPC/synectin recruits myosin VI to endocytic vesicles. Proc Natl Acad Sci U S A. 2006 August 22; 103(34): 12735–12740. Correction for Nagy et al., Genomewide demarcation of RNA polymerase II transcription units revealed by physical fractionation of chromatin PMCID: PMC1636762 Corrects: Peter L. Nagy, et al. Genomewide demarcation of RNA polymerase II transcription units revealed by physical fractionation of chromatin. Proc Natl Acad Sci U S A. 2003 May 27; 100(11): 6364–6369. Correction for Kupers et al., Transcranial magnetic stimulation of the visual cortex induces somatotopically organized qualia in blind subjects PMCID: PMC1622813 Corrects: Ron Kupers, et al. Transcranial magnetic stimulation of the visual cortex induces somatotopically organized qualia in blind subjects. Proc Natl Acad Sci U S A. 2006 August 29; 103(35): 13256–13260. Correction for Chaparro et al., Nonobese diabetic mice express aspects of both type 1 and type 2 diabetes PMCID: PMC1622814 Corrects: Rodolfo José Chaparro, et al. Nonobese diabetic mice express aspects of both type 1 and type 2 diabetes. Proc Natl Acad Sci U S A. 2006 August 15; 103(33): 12475–12480. Correction for Colton et al., NO synthase 2 (NOS2) deletion promotes multiple pathologies in a mouse model of Alzheimer's disease PMCID: PMC1622815 Corrects: C. A. Colton, et al. NO synthase 2 (NOS2) deletion promotes multiple pathologies in a mouse model of Alzheimer's disease. Proc Natl Acad Sci U S A. 2006 August 22; 103(34): 12867–12872. |
