| | This journal provides immediate access to some articles. This Week in PNAS Proc Natl Acad Sci U S A. 2006 May 2; 103(18): 6777–6778. doi: 10.1073/iti1806103.PMCID: PMC1458970 Commentaries Time, temperature, and load: The flaws of carbon nanotubes Rodney S. Ruoff PMCID: PMC1458971 Good old-fashioned (anti)sense Susan S. Golden PMCID: PMC2104490 Physical Sciences Applied Physical Sciences Nuclear spin noise imaging Norbert Müller and Alexej Jerschow PMCID: PMC1458973 Chemistry An electronic time scale in chemistry F. Remacle and R. D. Levine PMCID: PMC1458974 In situ superexchange electron transfer through a single molecule: A rectifying effect Alexei A. Kornyshev, Alexander M. Kuznetsov, and Jens Ulstrup PMCID: PMC1564272 Physics INAUGURAL ARTICLE by a Recently Elected Academy Member: Field-dependent ordered phases and Kondo phenomena in the filled skutterudite compound PrOs 4As 12M. B. Maple, N. P. Butch, N. A. Frederick, P.-C. Ho, J. R. Jeffries, T. A. Sayles, T. Yanagisawa, W. M. Yuhasz, Songxue Chi, H. J. Kang, J. W. Lynn, Pengcheng Dai, S. K. McCall, M. W. McElfresh, M. J. Fluss, Z. Henkie, and A. Pietraszko PMCID: PMC1458972 Biological Sciences Agricultural Sciences All possible modes of gene action are observed in a global comparison of gene expression in a maize F1 hybrid and its inbred parents Ruth A. Swanson-Wagner, Yi Jia, Rhonda DeCook, Lisa A. Borsuk, Dan Nettleton, and Patrick S. Schnable PMCID: PMC1447595 Biochemistry TSC1/TSC2 and Rheb have different effects on TORC1 and TORC2 activity Qian Yang, Ken Inoki, Eunjung Kim, and Kun-Liang Guan PMCID: PMC1458976 Site-specific proteolysis of the transcriptional coactivator HCF-1 can regulate its interaction with protein cofactors Jodi L. Vogel and Thomas M. Kristie PMCID: PMC1440766 Homodimerization of the G protein SRβ in the nucleotide-free state involves proline cis/trans isomerization in the switch II region Thomas U. Schwartz, Daniel Schmidt, Stephen G. Brohawn, and Günter Blobel PMCID: PMC1458978 Binding of 5′-GTP to the C-terminal FeS cluster of the radical S-adenosylmethionine enzyme MoaA provides insights into its mechanism Petra Hänzelmann and Hermann Schindelin PMCID: PMC1458979 Insights into the serine protease mechanism from atomic resolution structures of trypsin reaction intermediates Evette S. Radisky, Justin M. Lee, Chia-Jung Karen Lu, and Daniel E. Koshland, Jr. PMCID: PMC1458980 Stably tethered multifunctional structures of defined composition made by the dock and lock method for use in cancer targeting Edmund A. Rossi, David M. Goldenberg, Thomas M. Cardillo, William J. McBride, Robert M. Sharkey, and Chien-Hsing Chang PMCID: PMC1447525 Dual targeting of a single tRNATrp requires two different tryptophanyl-tRNA synthetases in Trypanosoma brucei Fabien Charrière, Sunna Helgadóttir, Elke K. Horn, Dieter Söll, and André Schneider PMCID: PMC1458982 DEMETER and REPRESSOR OF SILENCING 1 encode 5-methylcytosine DNA glycosylases Teresa Morales-Ruiz, Ana Pilar Ortega-Galisteo, María Isabel Ponferrada-Marín, María Isabel Martínez-Macías, Rafael R. Ariza, and Teresa Roldán-Arjona PMCID: PMC1458983 Biophysics Desensitization of mechano-gated K2P channels Eric Honoré, Amanda Jane Patel, Jean Chemin, Thomas Suchyna, and Frederick Sachs PMCID: PMC1458984 Histidines, heart of the hydrogen ion channel from influenza A virus: Toward an understanding of conductance and proton selectivity Jun Hu, Riqiang Fu, Katsuyuki Nishimura, Li Zhang, Huan-Xiang Zhou, David D. Busath, Viksita Vijayvergiya, and Timothy A. Cross PMCID: PMC1458985 Apolipoprotein B is conformationally flexible but anchored at a triolein/water interface: A possible model for lipoprotein surfaces Libo Wang, Mary T. Walsh, and Donald M. Small PMCID: PMC1458986 The inverted chevron plot measured by NMR relaxation reveals a native-like unfolding intermediate in acyl-CoA binding protein Kaare Teilum, Flemming M. Poulsen, and Mikael Akke PMCID: PMC1458987 Common attributes of native-state structures of proteins, disordered proteins, and amyloid Trinh X. Hoang, Luca Marsella, Antonio Trovato, Flavio Seno, Jayanth R. Banavar, and Amos Maritan PMCID: PMC1458988 From the Cover:
Electron microscopic structure of purified, active γ-secretase reveals an aqueous intramembrane chamber and two pores Vlado K. Lazarov, Patrick C. Fraering, Wenjuan Ye, Michael S. Wolfe, Dennis J. Selkoe, and Huilin Li PMCID: PMC1458989 Kinetics and mechanism of electron transfer in intact photosystem II and in the isolated reaction center: Pheophytin is the primary electron acceptor A. R. Holzwarth, M. G. Müller, M. Reus, M. Nowaczyk, J. Sander, and M. Rögner PMCID: PMC1458990 Cell Biology Phosphorylation of TNF-α converting enzyme by gastrin-releasing peptide induces amphiregulin release and EGF receptor activation Qing Zhang, Sufi M. Thomas, Vivian Wai Yan Lui, Sichuan Xi, Jill M. Siegfried, Huizhou Fan, Thomas E. Smithgall, Gordon B. Mills, and Jennifer Rubin Grandis PMCID: PMC1458991 Long-term self-renewal and directed differentiation of human embryonic stem cells in chemically defined conditions Shuyuan Yao, Shuibing Chen, Julie Clark, Ergeng Hao, Gillian M. Beattie, Alberto Hayek, and Sheng Ding PMCID: PMC1458992 Differential induction of BLT receptor expression on human endothelial cells by lipopolysacharide, cytokines, and leukotriene B4 Hong Qiu, Anne-Sofie Johansson, Mattias Sjöström, Min Wan, Oliver Schröder, Jan Palmblad, and Jesper Z. Haeggström PMCID: PMC1440767 Developmental Biology From the Cover:
Expression profiling the developing mammalian enteric nervous system identifies marker and candidate Hirschsprung disease genes Tiffany A. Heanue and Vassilis Pachnis PMCID: PMC1458994 The pupal specifier broad directs progressive morphogenesis in a direct-developing insect Deniz F. Erezyilmaz, Lynn M. Riddiford, and James W. Truman PMCID: PMC1458995 Ecology Observations on related ecological exponents T. Richard E. Southwood, Robert M. May, and George Sugihara PMCID: PMC1458996 Environmental Sciences An integrated approach for risk profiling and spatial prediction of Schistosoma mansoni–hookworm coinfection Giovanna Raso, Penelope Vounatsou, Burton H. Singer, Eliézer K. N′Goran, Marcel Tanner, and Jürg Utzinger PMCID: PMC1458997 Evolution Weak selection and recent mutational changes influence polymorphic synonymous mutations in humans Josep M. Comeron PMCID: PMC1458998 Genetics Genomewide gain-of-function genetic screen identifies functionally active genes in mouse embryonic stem cells Moshe Pritsker, Nicole R. Ford, Harry T. Jenq, and Ihor R. Lemischka PMCID: PMC1458999 Congenital progressive hydronephrosis (cph) is caused by an S256L mutation in aquaporin-2 that affects its phosphorylation and apical membrane accumulation Bradley W. McDill, Song-Zhe Li, Paul A. Kovach, Li Ding, and Feng Chen PMCID: PMC1459000 A yeast assay probes the interaction between botulinum neurotoxin serotype B and its SNARE substrate Hong Fang, Wentian Luo, Jim Henkel, Joseph Barbieri, and Neil Green PMCID: PMC1447522 Long-range multilocus haplotype phasing of the MHC Zhen Guo, Leroy Hood, Mari Malkki, and Effie W. Petersdorf PMCID: PMC1459002 A genetic variant at the fatty acid-binding protein aP2 locus reduces the risk for hypertriglyceridemia, type 2 diabetes, and cardiovascular disease G. Tuncman, E. Erbay, X. Hom, I. De Vivo, H. Campos, E. B. Rimm, and G. S. Hotamisligil PMCID: PMC1447594 Reducing the fitness cost of antibiotic resistance by amplification of initiator tRNA genes Annika I. Nilsson, Anna Zorzet, Anna Kanth, Sabina Dahlström, Otto G. Berg, and Dan I. Andersson PMCID: PMC1459004 Chromatin loop domain organization within the 4q35 locus in facioscapulohumeral dystrophy patients versus normal human myoblasts Andrei Petrov, Iryna Pirozhkova, Gilles Carnac, Dalila Laoudj, Marc Lipinski, and Yegor S. Vassetzky PMCID: PMC1459005 Histone chaperone Asf1 is required for histone H3 lysine 56 acetylation, a modification associated with S phase in mitosis and meiosis J. Recht, T. Tsubota, J. C. Tanny, R. L. Diaz, J. M. Berger, X. Zhang, B. A. Garcia, J. Shabanowitz, A. L. Burlingame, D. F. Hunt, P. D. Kaufman, and C. D. Allis PMCID: PMC1459006 Highly conserved syntenic blocks at the vertebrate Hox loci and conserved regulatory elements within and outside Hox gene clusters Alison P. Lee, Esther G. L. Koh, Alice Tay, Sydney Brenner, and Byrappa Venkatesh PMCID: PMC1459007 Immunology Differential expression of IFN-α and TRAIL/DR5 in lymphoid tissue of progressor versus nonprogressor HIV-1-infected patients Jean-Philippe Herbeuval, Jakob Nilsson, Adriano Boasso, Andrew W. Hardy, Michael J. Kruhlak, Stephanie A. Anderson, Matthew J. Dolan, Michel Dy, Jan Andersson, and Gene M. Shearer PMCID: PMC1444883 A multistep adhesion cascade for lymphoid progenitor cell homing to the thymus M. Lucila Scimone, Iannis Aifantis, Irina Apostolou, Harald von Boehmer, and Ulrich H. von Andrian PMCID: PMC1459009 Dysregulation of signaling pathways in CD45-deficient NK cells leads to differentially regulated cytotoxicity and cytokine production David G. T. Hesslein, Rayna Takaki, Michelle L. Hermiston, Arthur Weiss, and Lewis L. Lanier PMCID: PMC1459010 Medical Sciences Immune dysregulation accelerates atherosclerosis and modulates plaque composition in systemic lupus erythematosus Aleksandar K. Stanic, Charles M. Stein, Adam C. Morgan, Sergio Fazio, MacRae F. Linton, Edward K. Wakeland, Nancy J. Olsen, and Amy S. Major PMCID: PMC1459011 Pre-B cell proliferation and lymphoblastic leukemia/high-grade lymphoma in Eμ-miR155 transgenic mice Stefan Costinean, Nicola Zanesi, Yuri Pekarsky, Esmerina Tili, Stefano Volinia, Nyla Heerema, and Carlo M. Croce PMCID: PMC1459012 Evidence for metabolic and reproductive phenotypes in mothers of women with polycystic ovary syndrome Susan Sam, Richard S. Legro, Paulina A. Essah, Teimuraz Apridonidze, and Andrea Dunaif PMCID: PMC1459013 Targeting AMAP1 and cortactin binding bearing an atypical src homology 3/proline interface for prevention of breast cancer invasion and metastasis Shigeru Hashimoto, Mayumi Hirose, Ari Hashimoto, Masaki Morishige, Atsuko Yamada, Harumi Hosaka, Ken-ichi Akagi, Eiji Ogawa, Chitose Oneyama, Tsutomu Agatsuma, Masato Okada, Hidenori Kobayashi, Hiromi Wada, Hirofumi Nakano, Takahisa Ikegami, Atsushi Nakagawa, and Hisataka Sabe PMCID: PMC1459014 Beneficial and perverse effects of isoniazid preventive therapy for latent tuberculosis infection in HIV–tuberculosis coinfected populations Ted Cohen, Marc Lipsitch, Rochelle P. Walensky, and Megan Murray PMCID: PMC1459015 Toll-like receptor 2 signaling modulates the functions of CD4+CD25+ regulatory T cells Haiying Liu, Mousa Komai-Koma, Damo Xu, and Foo Y. Liew PMCID: PMC1444884 Microbiology From the Cover:
An internal antisense RNA regulates expression of the photosynthesis gene isiA Ulf Dühring, Ilka M. Axmann, Wolfgang R. Hess, and Annegret Wilde PMCID: PMC1459017 Molecular genetic anatomy of inter- and intraserotype variation in the human bacterial pathogen group A Streptococcus Stephen B. Beres, Ellen W. Richter, Michal J. Nagiec, Paul Sumby, Stephen F. Porcella, Frank R. DeLeo, and James M. Musser PMCID: PMC1459018 From the Cover:
Resting B cells as a transfer vehicle for Epstein–Barr virus infection of epithelial cells C. D. Shannon-Lowe, B. Neuhierl, G. Baldwin, A. B. Rickinson, and H.-J. Delecluse PMCID: PMC1459019 Crystal structure and catalytic mechanism of the LPS 3-O-deacylase PagL from Pseudomonas aeruginosa Lucy Rutten, Jeroen Geurtsen, Wietske Lambert, Jeroen J. M. Smolenaers, Alexandre M. Bonvin, Alex de Haan, Peter van der Ley, Maarten R. Egmond, Piet Gros, and Jan Tommassen PMCID: PMC1564273 Fungi and animals may share a common ancestor to nuclear receptors Chris Phelps, Valentina Gburcik, Elena Suslova, Peter Dudek, Fedor Forafonov, Nathalie Bot, Morag MacLean, Richard J. Fagan, and Didier Picard PMCID: PMC1459020 A plant-based oral vaccine to protect against systemic intoxication by Shiga toxin type 2 Sharon X. Wen, Louise D. Teel, Nicole A. Judge, and Alison D. O’Brien PMCID: PMC1459021 Substrate specificity of bacterial oligosaccharyltransferase suggests a common transfer mechanism for the bacterial and eukaryotic systems Michael Wacker, Mario F. Feldman, Nico Callewaert, Michael Kowarik, Bradley R. Clarke, Nicola L. Pohl, Marcela Hernandez, Enrique D. Vines, Miguel A. Valvano, Chris Whitfield, and Markus Aebi PMCID: PMC1459022 Persistence of nevirapine-resistant HIV-1 in women after single-dose nevirapine therapy for prevention of maternal-to-fetal HIV-1 transmission S. Palmer, V. Boltz, N. Martinson, F. Maldarelli, G. Gray, J. McIntyre, J. Mellors, L. Morris, and J. Coffin PMCID: PMC1459023 The primary function of RNA binding by the influenza A virus NS1 protein in infected cells: Inhibiting the 2′-5′ oligo (A) synthetase/RNase L pathway Ji-Young Min and Robert M. Krug PMCID: PMC1459024 Neuroscience Acute suppression, but not chronic genetic deficiency, of c-fos gene expression impairs long-term memory in aversive taste learning Yasunobu Yasoshima, Noritaka Sako, Emiko Senba, and Takashi Yamamoto PMCID: PMC1459025 A carbohydrate-binding protein, Galectin-1, promotes proliferation of adult neural stem cells Masanori Sakaguchi, Tetsuro Shingo, Takuya Shimazaki, Hirotaka James Okano, Mieko Shiwa, Satoru Ishibashi, Hideyuki Oguro, Mikiko Ninomiya, Toshihiko Kadoya, Hidenori Horie, Akira Shibuya, Hidehiro Mizusawa, Françoise Poirier, Hiromitsu Nakauchi, Kazunobu Sawamoto, and Hideyuki Okano PMCID: PMC1447526 NPAS2 as a transcriptional regulator of non-rapid eye movement sleep: Genotype and sex interactions Paul Franken, Carol A. Dudley, Sandi Jo Estill, Monique Barakat, Ryan Thomason, Bruce F. O'Hara, and Steven L. McKnight PMCID: PMC1459027 Sleep after spatial learning promotes covert reorganization of brain activity Pierre Orban, Géraldine Rauchs, Evelyne Balteau, Christian Degueldre, André Luxen, Pierre Maquet, and Philippe Peigneux PMCID: PMC1459028 Reversal of Alzheimer's-like pathology and behavior in human APP transgenic mice by mutation of Asp664 Veronica Galvan, Olivia F. Gorostiza, Surita Banwait, Marina Ataie, Anna V. Logvinova, Sandhya Sitaraman, Elaine Carlson, Sarah A. Sagi, Nathalie Chevallier, Kunlin Jin, David A. Greenberg, and Dale E. Bredesen PMCID: PMC1459029 Direct phosphorylation and regulation of poly(ADP-ribose) polymerase-1 by extracellular signal-regulated kinases 1/2 Tiina M. Kauppinen, Wai Y. Chan, Sang Won Suh, Amanda K. Wiggins, Eric J. Huang, and Raymond A. Swanson PMCID: PMC1459030 Conversion to the amyotrophic lateral sclerosis phenotype is associated with intermolecular linked insoluble aggregates of SOD1 in mitochondria Han-Xiang Deng, Yong Shi, Yoshiaki Furukawa, Hong Zhai, Ronggen Fu, Erdong Liu, George H. Gorrie, Mohammad S. Khan, Wu-Yen Hung, Eileen H. Bigio, Thomas Lukas, Mauro C. Dal Canto, Thomas V. O'Halloran, and Teepu Siddique PMCID: PMC1447523 From the Cover:
Disulfide cross-linked protein represents a significant fraction of ALS-associated Cu, Zn-superoxide dismutase aggregates in spinal cords of model mice Yoshiaki Furukawa, Ronggen Fu, Han-Xiang Deng, Teepu Siddique, and Thomas V. O'Halloran PMCID: PMC1447524 Pharmacology A neuropeptide Y Y5 antagonist selectively ameliorates body weight gain and associated parameters in diet-induced obese mice Akane Ishihara, Akio Kanatani, Satoshi Mashiko, Takeshi Tanaka, Masayasu Hidaka, Akira Gomori, Hisashi Iwaasa, Naomi Murai, Shin-ichiro Egashira, Takashi Murai, Yuko Mitobe, Hiroko Matsushita, Osamu Okamoto, Nagaaki Sato, Makoto Jitsuoka, Takahiro Fukuroda, Tomoyuki Ohe, Xiaoming Guan, Douglas J. MacNeil, Lex H. T. Van der Ploeg, Masaru Nishikibe, Yasuyuki Ishii, Masaki Ihara, and Takehiro Fukami PMCID: PMC1459032 Physiology Quantitative phosphoproteomics of vasopressin-sensitive renal cells: Regulation of aquaporin-2 phosphorylation at two sites Jason D. Hoffert, Trairak Pisitkun, Guanghui Wang, Rong-Fong Shen, and Mark A. Knepper PMCID: PMC1459033 Lung dysfunction causes systemic hypoxia in estrogen receptor β knockout (ERβ−/−) mice Andrea Morani, Rodrigo P. A. Barros, Otabek Imamov, Kjell Hultenby, Anders Arner, Margaret Warner, and Jan-Åke Gustafsson PMCID: PMC1459034 Plant Biology Remote sensing of future competitors: Impacts on plant defenses Miriam M. Izaguirre, Carlos A. Mazza, Mariela Biondini, Ian T. Baldwin, and Carlos L. Ballaré PMCID: PMC1459035 Genomewide comparative analysis of alternative splicing in plants Bing-Bing Wang and Volker Brendel PMCID: PMC1459036 Psychology Wild rhesus monkeys generate causal inferences about possible and impossible physical transformations in the absence of experience Marc Hauser and Bailey Spaulding PMCID: PMC1459037 Computational and neurobiological mechanisms underlying cognitive flexibility David Badre and Anthony D. Wagner PMCID: PMC1459038 Microsaccades are triggered by low retinal image slip Ralf Engbert and Konstantin Mergenthaler PMCID: PMC1459039 Sustainability Science An integrated approach for risk profiling and spatial prediction of Schistosoma mansoni–hookworm coinfection Giovanna Raso, Penelope Vounatsou, Burton H. Singer, Eliézer K. N′Goran, Marcel Tanner, and Jürg Utzinger PMCID: PMC1458997 Social Sciences Psychology Wild rhesus monkeys generate causal inferences about possible and impossible physical transformations in the absence of experience Marc Hauser and Bailey Spaulding PMCID: PMC1459037 Correction Correction for Tadigotla et al., Thermodynamic and kinetic modeling of transcriptional pausing PMCID: PMC1459040 Corrects: Vasisht R. Tadigotla, et al. Thermodynamic and kinetic modeling of transcriptional pausing. Proc Natl Acad Sci U S A. 2006 March 21; 103(12): 4439–4444. |
