| | This journal provides immediate access to some articles. This Week in PNAS Proc Natl Acad Sci U S A. 2006 March 28; 103(13): 4795–4796. doi: 10.1073/pnas.iti1306103.PMCID: PMC1458745 Commentaries Using photon statistics to boost microscopy resolution Xavier Michalet and Shimon Weiss PMCID: PMC1458746 Finding the final pieces of the vitamin B12 biosynthetic jigsaw Martin J. Warren PMCID: PMC1458747 Legume flowers bear fruit Quentin C. B. Cronk PMCID: PMC1458748 The evolution of viral emergence Edward C. Holmes PMCID: PMC1458749 Profile Profile of Michael E. Moseley Regina Nuzzo PMCID: PMC1458750 Physical Sciences Applied Physical Sciences Ionic contrast terahertz near-field imaging of axonal water fluxes Jean-Baptiste Masson, Martin-Pierre Sauviat, Jean-Louis Martin, and Guilhem Gallot PMCID: PMC1458751 Scanning probe acceleration microscopy (SPAM) in fluids: Mapping mechanical properties of surfaces at the nanoscale Justin Legleiter, Matthew Park, Brian Cusick, and Tomasz Kowalewski PMCID: PMC1458752 Chemistry Probing mucin-type O-linked glycosylation in living animals Danielle H. Dube, Jennifer A. Prescher, Chi N. Quang, and Carolyn R. Bertozzi PMCID: PMC1405625 Dynamic behavior of fully solvated β2-adrenergic receptor, embedded in the membrane with bound agonist or antagonist Peter Spijker, Nagarajan Vaidehi, Peter L. Freddolino, Peter A. J. Hilbers, and William A. Goddard, III PMCID: PMC1458764 Engineering Collection, focusing, and metering of DNA in microchannels using addressable electrode arrays for portable low-power bioanalysis Faisal A. Shaikh and Victor M. Ugaz PMCID: PMC1458754 Improved performance of quantum cascade lasers through a scalable, manufacturable epitaxial-side-down mounting process Alexei Tsekoun, Rowel Go, Michael Pushkarsky, Manijeh Razeghi, and C. Kumar N. Patel PMCID: PMC1403566 Mathematics The Strong Anick Conjecture Vesselin Drensky and Jie-Tai Yu PMCID: PMC1458756 Physics Scanning probe acceleration microscopy (SPAM) in fluids: Mapping mechanical properties of surfaces at the nanoscale Justin Legleiter, Matthew Park, Brian Cusick, and Tomasz Kowalewski PMCID: PMC1458752 Biological Sciences Applied Biological Sciences High-sensitivity bacterial detection using biotin-tagged phage and quantum-dot nanocomplexes Rotem Edgar, Michael McKinstry, Jeeseong Hwang, Amos B. Oppenheim, Richard A. Fekete, Gary Giulian, Carl Merril, Kunio Nagashima, and Sankar Adhya PMCID: PMC1458757 Biochemistry Analysis of protein solvent interactions in glucose dehydrogenase from the extreme halophile Haloferax mediterranei K. Linda Britton, Patrick J. Baker, Martin Fisher, Sergey Ruzheinikov, D. James Gilmour, María-José Bonete, Juan Ferrer, Carmen Pire, Julia Esclapez, and David W. Rice PMCID: PMC1458758 Structure of the MTIP–MyoA complex, a key component of the malaria parasite invasion motor Jürgen Bosch, Stewart Turley, Thomas M. Daly, Stephen M. Bogh, Michelle L. Villasmil, Claudia Roach, Na Zhou, Joanne M. Morrisey, Akhil B. Vaidya, Lawrence W. Bergman, and Wim G. J. Hol PMCID: PMC1458759 Translational repression is sufficient for gene silencing by bacterial small noncoding RNAs in the absence of mRNA destruction Teppei Morita, Yukari Mochizuki, and Hiroji Aiba PMCID: PMC1458760 A structural role for ATP in the formation and stability of the human origin recognition complex Anand Ranjan and Manfred Gossen PMCID: PMC1458761 Role of DNA bubble rewinding in enzymatic transcription termination Joo-Seop Park and Jeffrey W. Roberts PMCID: PMC1405909 Alternative mutations of a positively selected residue elicit gain or loss of functionalities in enzyme evolution Malena A. Norrgård, Ylva Ivarsson, Kaspars Tars, and Bengt Mannervik PMCID: PMC1458763 Dynamic behavior of fully solvated β2-adrenergic receptor, embedded in the membrane with bound agonist or antagonist Peter Spijker, Nagarajan Vaidehi, Peter L. Freddolino, Peter A. J. Hilbers, and William A. Goddard, III PMCID: PMC1458764 Biophysics A role for direct interactions in the modulation of rhodopsin by ω-3 polyunsaturated lipids Alan Grossfield, Scott E. Feller, and Michael C. Pitman PMCID: PMC1458765 Switch interactions control energy frustration and multiple flagellar filament structures Akio Kitao, Koji Yonekura, Saori Maki-Yonekura, Fadel A. Samatey, Katsumi Imada, Keiichi Namba, and Nobuhiro Go PMCID: PMC1458766 Differential interaction of spin-labeled arrestin with inactive and active phosphorhodopsin Susan M. Hanson, Derek J. Francis, Sergey A. Vishnivetskiy, Elena A. Kolobova, Wayne L. Hubbell, Candice S. Klug, and Vsevolod V. Gurevich PMCID: PMC1458767 Reconstitution of the transition from lamellipodium to filopodium in a membrane-free system Lior Haviv, Yifat Brill-Karniely, Rachel Mahaffy, Frederic Backouche, Avinoam Ben-Shaul, Thomas D. Pollard, and Anne Bernheim-Groswasser PMCID: PMC1458768 Experimental determination of the radiation dose limit for cryocooled protein crystals Robin Leslie Owen, Enrique Rudiño-Piñera, and Elspeth F. Garman PMCID: PMC1458769 Pertactin β-helix folding mechanism suggests common themes for the secretion and folding of autotransporter proteins Mirco Junker, Christopher C. Schuster, Andrew V. McDonnell, Kelli A. Sorg, Mary C. Finn, Bonnie Berger, and Patricia L. Clark PMCID: PMC1458770 Extended subnanosecond structural dynamics of myoglobin revealed by Laue crystallography Dominique Bourgeois, Beatrice Vallone, Alessandro Arcovito, Giuliano Sciara, Friedrich Schotte, Philip A. Anfinrud, and Maurizio Brunori PMCID: PMC1458771 From the Cover:
Role of target geometry in phagocytosis Julie A. Champion and Samir Mitragotri PMCID: PMC1458772 Exact solution of the Eigen model with general fitness functions and degradation rates David B. Saakian and Chin-Kun Hu PMCID: PMC1458773 Cell Biology Probing mucin-type O-linked glycosylation in living animals Danielle H. Dube, Jennifer A. Prescher, Chi N. Quang, and Carolyn R. Bertozzi PMCID: PMC1405625 Microparadigms: Chains of collective reasoning in publications about molecular interactions Andrey Rzhetsky, Ivan Iossifov, Ji Meng Loh, and Kevin P. White PMCID: PMC1402650 COMP-angiopoietin-1 promotes wound healing through enhanced angiogenesis, lymphangiogenesis, and blood flow in a diabetic mouse model Chung-Hyun Cho, Hoon-Ki Sung, Kyung-Tae Kim, Hyae Gyeong Cheon, Goo Taeg Oh, Hyo Jeong Hong, Ook-Joon Yoo, and Gou Young Koh PMCID: PMC1458775 Autophagic programmed cell death by selective catalase degradation Li Yu, Fengyi Wan, Sudeshna Dutta, Sarah Welsh, ZhiHua Liu, Eric Freundt, Eric H. Baehrecke, and Michael Lenardo PMCID: PMC1458776 Proteasomal degradation of ubiquitinated Insig proteins is determined by serine residues flanking ubiquitinated lysines Joon No Lee, Yi Gong, Xiangyu Zhang, and Jin Ye PMCID: PMC1405624 Functional ion channels in pulmonary alveolar type I cells support a role for type I cells in lung ion transport Meshell D. Johnson, Hui-Fang Bao, My N. Helms, Xi-Juan Chen, Zac Tigue, Lucky Jain, Leland G. Dobbs, and Douglas C. Eaton PMCID: PMC1458778 Developmental Biology From the Cover:
Control of petal shape and floral zygomorphy in Lotus japonicus Xianzhong Feng, Zhong Zhao, Zhaoxia Tian, Shilei Xu, Yonghai Luo, Zhigang Cai, Yumei Wang, Jun Yang, Zheng Wang, Lin Weng, Jianghua Chen, Leiying Zheng, Xizhi Guo, Jianghong Luo, Shusei Sato, Satoshi Tabata, Wei Ma, Xiangling Cao, Xiaohe Hu, Chongrong Sun, and Da Luo PMCID: PMC1458779 The protein ENH is a cytoplasmic sequestration factor for Id2 in normal and tumor cells from the nervous system Anna Lasorella and Antonio Iavarone PMCID: PMC1458780 TEX14 is essential for intercellular bridges and fertility in male mice Michael P. Greenbaum, Wei Yan, Meng-Hsieh Wu, Yi-Nan Lin, Julio E. Agno, Manju Sharma, Robert E. Braun, Aleksandar Rajkovic, and Martin M. Matzuk PMCID: PMC1458781 Chx10 is required to block photoreceptor differentiation but is dispensable for progenitor proliferation in the postnatal retina Izzy Livne-bar, Marek Pacal, Melissa C. Cheung, Mark Hankin, Judy Trogadis, Danian Chen, Kimberley M. Dorval, and Rod Bremner PMCID: PMC1458782 Evolution From the Cover:
Venezuelan encephalitis emergence mediated by a phylogenetically predicted viral mutation Michael Anishchenko, Richard A. Bowen, Slobodan Paessler, Laura Austgen, Ivorlyne P. Greene, and Scott C. Weaver PMCID: PMC1458783 Revised age estimates for the later Paleogene mammal faunas of Egypt and Oman Erik R. Seiffert PMCID: PMC1458784 Genetics An intronic insertion in KPL2 results in aberrant splicing and causes the immotile short-tail sperm defect in the pig Anu Sironen, Bo Thomsen, Magnus Andersson, Virpi Ahola, and Johanna Vilkki PMCID: PMC1458785 LHP1, the Arabidopsis homologue of HETEROCHROMATIN PROTEIN1, is required for epigenetic silencing of FLC Joshua S. Mylne, Lynne Barrett, Federico Tessadori, Stéphane Mesnage, Lianna Johnson, Yana V. Bernatavichute, Steven E. Jacobsen, Paul Fransz, and Caroline Dean PMCID: PMC1458786 Genetic independence of mouse measures of some aspects of novelty seeking Christopher L. Kliethermes and John C. Crabbe PMCID: PMC1405908 Immunology CD4+ regulatory T cell responses induced by T cell vaccination in patients with multiple sclerosis Jian Hong, Ying C. Q. Zang, Hong Nie, and Jingwu Z. Zhang PMCID: PMC1458788 Downstream boundary of chromosomal R-loops at murine switch regions: Implications for the mechanism of class switch recombination Feng-Ting Huang, Kefei Yu, Chih-Lin Hsieh, and Michael R. Lieber PMCID: PMC1458789 An evolutionarily mobile antigen receptor variable region gene: Doubly rearranging NAR-TcR genes in sharks Michael F. Criscitiello, Mark Saltis, and Martin F. Flajnik PMCID: PMC1458790 Proteasomes shape the repertoire of T cells participating in antigen-specific immune responses Philipp Osterloh, Kathrin Linkemann, Stefan Tenzer, Hans-Georg Rammensee, Markus P. Radsak, Dirk H. Busch, and Hansjörg Schild PMCID: PMC1458791 Aβ-induced meningoencephalitis is IFN-γ-dependent and is associated with T cell-dependent clearance of Aβ in a mouse model of Alzheimer's disease Alon Monsonego, Jaime Imitola, Sanja Petrovic, Victor Zota, Anna Nemirovsky, Rona Baron, Yair Fisher, Trevor Owens, and Howard L. Weiner PMCID: PMC1458792 Medical Sciences Nano neuro knitting: Peptide nanofiber scaffold for brain repair and axon regeneration with functional return of vision Rutledge G. Ellis-Behnke, Yu-Xiang Liang, Si-Wei You, David K. C. Tay, Shuguang Zhang, Kwok-Fai So, and Gerald E. Schneider PMCID: PMC1405623 Galectin-3 regulates myofibroblast activation and hepatic fibrosis Neil C. Henderson, Alison C. Mackinnon, Sarah L. Farnworth, Francoise Poirier, Francesco P. Russo, John P. Iredale, Christopher Haslett, Kenneth J. Simpson, and Tariq Sethi PMCID: PMC1458794 Optophysiology: Depth-resolved probing of retinal physiology with functional ultrahigh-resolution optical coherence tomography K. Bizheva, R. Pflug, B. Hermann, B. Považay, H. Sattmann, P. Qiu, E. Anger, H. Reitsamer, S. Popov, J. R. Taylor, A. Unterhuber, P. Ahnelt, and W. Drexler PMCID: PMC1405907 Conditional and specific NF-κB blockade protects pancreatic beta cells from diabetogenic agents R. Eldor, A. Yeffet, K. Baum, V. Doviner, D. Amar, Y. Ben-Neriah, G. Christofori, A. Peled, J. C. Carel, C. Boitard, T. Klein, P. Serup, D. L. Eizirik, and D. Melloul PMCID: PMC1458796 MicroRNA fingerprints during human megakaryocytopoiesis Ramiro Garzon, Flavia Pichiorri, Tiziana Palumbo, Rodolfo Iuliano, Amelia Cimmino, Rami Aqeilan, Stefano Volinia, Darshna Bhatt, Hansjuerg Alder, Guido Marcucci, George A. Calin, Chang-Gong Liu, Clara D. Bloomfield, Michael Andreeff, and Carlo M. Croce PMCID: PMC1458797 Familial hypercatabolic hypoproteinemia caused by deficiency of the neonatal Fc receptor, FcRn, due to a mutant β2-microglobulin gene Manzoor A. Wani, Lynn D. Haynes, Jonghan Kim, C. L. Bronson, Chaity Chaudhury, Sudhasri Mohanty, Thomas A. Waldmann, John M. Robinson, and Clark L. Anderson PMCID: PMC1458798 Ab-induced ectodomain shedding mediates hepatocyte growth factor receptor down-regulation and hampers biological activity Annalisa Petrelli, Paola Circosta, Luisa Granziero, Massimiliano Mazzone, Alberto Pisacane, Silvia Fenoglio, Paolo M. Comoglio, and Silvia Giordano PMCID: PMC1458799 Defining the BK channel domains required for β1-subunit modulation John P. Morrow, Sergey I. Zakharov, Guoxia Liu, Lin Yang, Andrea J. Sok, and Steven O. Marx PMCID: PMC1458800 Microbiology Directed antigen delivery as a vaccine strategy for an intracellular bacterial pathogen H. G. Archie Bouwer, Christine Alberti-Segui, Megan J. Montfort, Nathan D. Berkowitz, and Darren E. Higgins PMCID: PMC1458801 Discovery of an RNA virus 3′→5′ exoribonuclease that is critically involved in coronavirus RNA synthesis Ekaterina Minskaia, Tobias Hertzig, Alexander E. Gorbalenya, Valérie Campanacci, Christian Cambillau, Bruno Canard, and John Ziebuhr PMCID: PMC1458802 From the Cover:
A previously undescribed pathway for pyrimidine catabolism Kevin D. Loh, Prasad Gyaneshwar, Eirene Markenscoff Papadimitriou, Rebecca Fong, Kwang-Seo Kim, Rebecca Parales, Zhongrui Zhou, William Inwood, and Sydney Kustu PMCID: PMC1458803 Neuroscience Expression of Caenorhabditis elegans neurotransmitter receptors and ion channels in Xenopus oocytes Ataúlfo Martínez-Torres and Ricardo Miledi PMCID: PMC1458804 Enhancement of long-term memory retention and short-term synaptic plasticity in cbl-b null mice Dong Ping Tan, Qi-Ying Liu, Naohiro Koshiya, Hua Gu, and Daniel Alkon PMCID: PMC1458805 Dynamic properties of orientation discrimination assessed by using classification images Isabelle Mareschal, Steven C. Dakin, and Peter J. Bex PMCID: PMC1458806 Disruption of axo–glial junctions causes cytoskeletal disorganization and degeneration of Purkinje neuron axons German P. Garcia-Fresco, Aurea D. Sousa, Anilkumar M. Pillai, Sheryl S. Moy, Jacqueline N. Crawley, Lino Tessarollo, Jeffrey L. Dupree, and Manzoor A. Bhat PMCID: PMC1405910 Neurogenin1 is a determinant of zebrafish basal forebrain dopaminergic neurons and is regulated by the conserved zinc finger protein Tof/Fezl Jae-Yeon Jeong, Zev Einhorn, Sara Mercurio, Susie Lee, Billy Lau, Marina Mione, Stephen W. Wilson, and Su Guo PMCID: PMC1458808 The cholinergic antagonist α-bungarotoxin also binds and blocks a subset of GABA receptors Corey M. McCann, John Bracamontes, Joe Henry Steinbach, and Joshua R. Sanes PMCID: PMC1458809 Elk-1 associates with the mitochondrial permeability transition pore complex in neurons L. E. Barrett, E. J. Van Bockstaele, J. Y. Sul, H. Takano, P. G. Haydon, and J. H. Eberwine PMCID: PMC1458810 Early-onset behavioral and synaptic deficits in a mouse model of Alzheimer's disease J. Steven Jacobsen, Chi-Cheng Wu, Jeffrey M. Redwine, Thomas A. Comery, Robert Arias, Mark Bowlby, Robert Martone, John H. Morrison, Menelas N. Pangalos, Peter H. Reinhart, and Floyd E. Bloom PMCID: PMC1405622 The laterodorsal tegmentum is essential for burst firing of ventral tegmental area dopamine neurons D. J. Lodge and A. A. Grace PMCID: PMC1458812 Pharmacology An l-RNA-based aquaretic agent that inhibits vasopressin in vivo Werner G. Purschke, Dirk Eulberg, Klaus Buchner, Stefan Vonhoff, and Sven Klussmann PMCID: PMC1458813 Essential role for hematopoietic prostaglandin D2 synthase in the control of delayed type hypersensitivity Seema G. Trivedi, Justine Newson, Ravindra Rajakariar, Thomas S. Jacques, Robert Hannon, Yoshihide Kanaoka, Naomi Eguchi, Paul Colville-Nash, and Derek W. Gilroy PMCID: PMC1458814 Structural model for γ-aminobutyric acid receptor noncompetitive antagonist binding: Widely diverse structures fit the same site Ligong Chen, Kathleen A. Durkin, and John E. Casida PMCID: PMC1458815 Carbon monoxide rescues ischemic lungs by interrupting MAPK-driven expression of early growth response 1 gene and its downstream target genes Snigdha Mishra, Tomoyuki Fujita, Vibha N. Lama, Douglas Nam, Hui Liao, Morihito Okada, Kanji Minamoto, Yasushi Yoshikawa, Hiroaki Harada, and David J. Pinsky PMCID: PMC1458816 Physiology Rapid signaling at the plasma membrane by a nuclear receptor for thyroid hormone Nina M. Storey, Saverio Gentile, Hemayet Ullah, Angela Russo, Michelle Muessel, Christian Erxleben, and David L. Armstrong PMCID: PMC1458817 Rac GTPase signaling through the PP5 protein phosphatase Saverio Gentile, Thomas Darden, Christian Erxleben, Charles Romeo, Angela Russo, Negin Martin, Sandra Rossie, and David L. Armstrong PMCID: PMC1458818 Induction of colitis causes inflammatory responses in fat depots: Evidence for substance P pathways in human mesenteric preadipocytes Iordanes Karagiannides, Efi Kokkotou, Morris Tansky, Tamara Tchkonia, Nino Giorgadze, Michael O'Brien, Susan E. Leeman, James L. Kirkland, and Charalabos Pothoulakis PMCID: PMC1458819 Properties of human connexin 31, which is implicated in hereditary dermatological disease and deafness Charles K. Abrams, Mona M. Freidin, Vytas K. Verselis, Thaddeus A. Bargiello, David P. Kelsell, Gabriele Richard, Michael V. L. Bennett, and Feliksas F. Bukauskas PMCID: PMC1458820 Central muscarinic cholinergic regulation of the systemic inflammatory response during endotoxemia Valentin A. Pavlov, Mahendar Ochani, Margot Gallowitsch-Puerta, Kanta Ochani, Jared M. Huston, Christopher J. Czura, Yousef Al-Abed, and Kevin J. Tracey PMCID: PMC1405626 Plant Biology Mechanisms of chromosome number reduction in Arabidopsis thaliana and related Brassicaceae species Martin A. Lysak, Alexandre Berr, Ales Pecinka, Renate Schmidt, Kim McBreen, and Ingo Schubert PMCID: PMC1458822 Eukaryotic control on bacterial cell cycle and differentiation in the Rhizobium–legume symbiosis Peter Mergaert, Toshiki Uchiumi, Benoît Alunni, Gwénaëlle Evanno, Angélique Cheron, Olivier Catrice, Anne-Elisabeth Mausset, Frédérique Barloy-Hubler, Francis Galibert, Adam Kondorosi, and Eva Kondorosi PMCID: PMC1458823 From the Cover:
Functional identification of an Arabidopsis pectin biosynthetic homogalacturonan galacturonosyltransferase Jason D. Sterling, Melani A. Atmodjo, Sarah E. Inwood, V. S. Kumar Kolli, Heather F. Quigley, Michael G. Hahn, and Debra Mohnen PMCID: PMC1458824 Social Sciences Social Sciences Microparadigms: Chains of collective reasoning in publications about molecular interactions Andrey Rzhetsky, Ivan Iossifov, Ji Meng Loh, and Kevin P. White PMCID: PMC1402650 Corrections Correction for Eytan et al., Roles of the anaphase-promoting complex/cyclosome and of its activator Cdc20 in functional substrate binding PMCID: PMC1458825 Corrects: Esther Eytan, et al. Roles of the anaphase-promoting complex/cyclosome and of its activator Cdc20 in functional substrate binding. Proc Natl Acad Sci U S A. 2006 February 14; 103(7): 2081–2086. Correction for Gottenberg et al., Activation of IFN pathways and plasmacytoid dendritic cell recruitment in target organs of primary Sjögren's syndrome PMCID: PMC1458826 Corrects: Jacques-Eric Gottenberg, et al. Activation of IFN pathways and plasmacytoid dendritic cell recruitment in target organs of primary Sjögren’s syndrome. Proc Natl Acad Sci U S A. 2006 February 21; 103(8): 2770–2775. Correction for Hao et al., SNOSID, a proteomic method for identification of cysteine S-nitrosylation sites in complex protein mixtures PMCID: PMC1458827 Corrects: Gang Hao, et al. SNOSID, a proteomic method for identification of cysteine S-nitrosylation sites in complex protein mixtures. Proc Natl Acad Sci U S A. 2006 January 24; 103(4): 1012–1017. Correction for Roper et al., Defective cerebellar response to mitogenic Hedgehog signaling in Down’s syndrome mice PMCID: PMC1458828 Corrects: Randall J. Roper, et al. Defective cerebellar response to mitogenic Hedgehog signaling in Down's syndrome mice. Proc Natl Acad Sci U S A. 2006 January 31; 103(5): 1452–1456. |
