| | This journal provides immediate access to some articles. Colloquium Papers INTRODUCTION - Links between recombination and replication: Vital roles of recombination Charles Radding Proc Natl Acad Sci U S A. 2001 July 17; 98(15): 8172. doi: 10.1073/pnas.161004898.PMCID: PMC37417 Historical overview: Searching for replication help in all of the rec places Michael M. Cox Proc Natl Acad Sci U S A. 2001 July 17; 98(15): 8173–8180. doi: 10.1073/pnas.131004998.PMCID: PMC37418 Rescue of arrested replication forks by homologous recombination Bénédicte Michel, Maria-Jose Flores, Enrique Viguera, Gianfranco Grompone, Marie Seigneur, and Vladimir Bidnenko Proc Natl Acad Sci U S A. 2001 July 17; 98(15): 8181–8188. doi: 10.1073/pnas.111008798.PMCID: PMC37419 Circles: The replication-recombination-chromosome segregation connection François-Xavier Barre, Britta Søballe, Bénédicte Michel, Mira Aroyo, Malcolm Robertson, and David Sherratt Proc Natl Acad Sci U S A. 2001 July 17; 98(15): 8189–8195. doi: 10.1073/pnas.111008998.PMCID: PMC37420 Participation of recombination proteins in rescue of arrested replication forks in UV-irradiated Escherichia coli need not involve recombination Justin Courcelle and Philip C. Hanawalt Proc Natl Acad Sci U S A. 2001 July 17; 98(15): 8196–8202. doi: 10.1073/pnas.121008898.PMCID: PMC37421 Effects of mutations involving cell division, recombination, and chromosome dimer resolution on a priA2kan mutant Jesse D. McCool and Steven J. Sandler Proc Natl Acad Sci U S A. 2001 July 17; 98(15): 8203–8210. doi: 10.1073/pnas.121007698.PMCID: PMC37422 RecA protein promotes the regression of stalled replication forks in vitro Mara E. Robu, Ross B. Inman, and Michael M. Cox Proc Natl Acad Sci U S A. 2001 July 17; 98(15): 8211–8218. doi: 10.1073/pnas.131022698.PMCID: PMC37423 Topological challenges to DNA replication: Conformations at the fork Lisa Postow, Nancy J. Crisona, Brian J. Peter, Christine D. Hardy, and Nicholas R. Cozzarelli Proc Natl Acad Sci U S A. 2001 July 17; 98(15): 8219–8226. doi: 10.1073/pnas.111006998.PMCID: PMC37424 Rescue of stalled replication forks by RecG: Simultaneous translocation on the leading and lagging strand templates supports an active DNA unwinding model of fork reversal and Holliday junction formation Peter McGlynn and Robert G. Lloyd Proc Natl Acad Sci U S A. 2001 July 17; 98(15): 8227–8234. doi: 10.1073/pnas.111008698.PMCID: PMC37425 Formation of Holliday junctions by regression of nascent DNA in intermediates containing stalled replication forks: RecG stimulates regression even when the DNA is negatively supercoiled Peter McGlynn, Robert G. Lloyd, and Kenneth J. Marians Proc Natl Acad Sci U S A. 2001 July 17; 98(15): 8235–8240. doi: 10.1073/pnas.121007798.PMCID: PMC37426 Single-strand interruptions in replicating chromosomes cause double-strand breaks Andrei Kuzminov Proc Natl Acad Sci U S A. 2001 July 17; 98(15): 8241–8246. doi: 10.1073/pnas.131009198.PMCID: PMC37427 Handoff from recombinase to replisome: Insights from transposition Hiroshi Nakai, Victoria Doseeva, and Jessica M. Jones Proc Natl Acad Sci U S A. 2001 July 17; 98(15): 8247–8254. doi: 10.1073/pnas.111007898.PMCID: PMC37428 Break-induced replication: A review and an example in budding yeast Eliyahu Kraus, Wai-Ying Leung, and James E. Haber Proc Natl Acad Sci U S A. 2001 July 17; 98(15): 8255–8262. doi: 10.1073/pnas.151008198.PMCID: PMC37429 Links between replication and recombination in Saccharomyces cerevisiae: A hypersensitive requirement for homologous recombination in the absence of Rad27 activity Hélène Debrauwère, Sophie Loeillet, Waka Lin, Judith Lopes, and Alain Nicolas Proc Natl Acad Sci U S A. 2001 July 17; 98(15): 8263–8269. doi: 10.1073/pnas.121075598.PMCID: PMC37430 Evidence that replication fork components catalyze establishment of cohesion between sister chromatids Dena R. Carson and Michael F. Christman Proc Natl Acad Sci U S A. 2001 July 17; 98(15): 8270–8275. doi: 10.1073/pnas.131022798.PMCID: PMC37431 Rad52 forms DNA repair and recombination centers during S phase Michael Lisby, Rodney Rothstein, and Uffe H. Mortensen Proc Natl Acad Sci U S A. 2001 July 17; 98(15): 8276–8282. doi: 10.1073/pnas.121006298.PMCID: PMC37432 A yeast gene, MGS1, encoding a DNA-dependent AAA+ ATPase is required to maintain genome stability Takashi Hishida, Hiroshi Iwasaki, Takayuki Ohno, Takashi Morishita, and Hideo Shinagawa Proc Natl Acad Sci U S A. 2001 July 17; 98(15): 8283–8289. doi: 10.1073/pnas.121009098.PMCID: PMC37433 The tight linkage between DNA replication and double-strand break repair in bacteriophage T4 James W. George, Bradley A. Stohr, Daniel J. Tomso, and Kenneth N. Kreuzer Proc Natl Acad Sci U S A. 2001 July 17; 98(15): 8290–8297. doi: 10.1073/pnas.131007598.PMCID: PMC37434 Mediator proteins orchestrate enzyme-ssDNA assembly during T4 recombination-dependent DNA replication and repair Jill S. Bleuit, Hang Xu, Yujie Ma, Tongsheng Wang, Jie Liu, and Scott W. Morrical Proc Natl Acad Sci U S A. 2001 July 17; 98(15): 8298–8305. doi: 10.1073/pnas.131007498.PMCID: PMC37435 Two recombination-dependent DNA replication pathways of bacteriophage T4, and their roles in mutagenesis and horizontal gene transfer Gisela Mosig, John Gewin, Andreas Luder, Nancy Colowick, and Daniel Vo Proc Natl Acad Sci U S A. 2001 July 17; 98(15): 8306–8311. doi: 10.1073/pnas.131007398.PMCID: PMC37436 Bacteriophage T4 gene 41 helicase and gene 59 helicase-loading protein: A versatile couple with roles in replication and recombination Charles E. Jones, Timothy C. Mueser, Kathleen C. Dudas, Kenneth N. Kreuzer, and Nancy G. Nossal Proc Natl Acad Sci U S A. 2001 July 17; 98(15): 8312–8318. doi: 10.1073/pnas.121009398.PMCID: PMC37437 Instability of repetitive DNA sequences: The role of replication in multiple mechanisms Malgorzata Bzymek and Susan T. Lovett Proc Natl Acad Sci U S A. 2001 July 17; 98(15): 8319–8325. doi: 10.1073/pnas.111008398.PMCID: PMC37438 Repeat expansion by homologous recombination in the mouse germ line at palindromic sequences Zhi-Hong Zhou, Ercan Akgün, and Maria Jasin Proc Natl Acad Sci U S A. 2001 July 17; 98(15): 8326–8333. doi: 10.1073/pnas.151008498.PMCID: PMC37439 Stationary-phase mutation in the bacterial chromosome: Recombination protein and DNA polymerase IV dependence Harold J. Bull, Mary-Jane Lombardo, and Susan M. Rosenberg Proc Natl Acad Sci U S A. 2001 July 17; 98(15): 8334–8341. doi: 10.1073/pnas.151009798.PMCID: PMC37440 Managing DNA polymerases: Coordinating DNA replication, DNA repair, and DNA recombination Mark D. Sutton and Graham C. Walker Proc Natl Acad Sci U S A. 2001 July 17; 98(15): 8342–8349. doi: 10.1073/pnas.111036998.PMCID: PMC37441 Roles of DNA polymerases V and II in SOS-induced error-prone and error-free repair in Escherichia coli Phuong Pham, Savithri Rangarajan, Roger Woodgate, and Myron F. Goodman Proc Natl Acad Sci U S A. 2001 July 17; 98(15): 8350–8354. doi: 10.1073/pnas.111007198.PMCID: PMC37442 Accuracy of lesion bypass by yeast and human DNA polymerase η M. Todd Washington, Robert E. Johnson, Louise Prakash, and Satya Prakash Proc Natl Acad Sci U S A. 2001 July 17; 98(15): 8355–8360. doi: 10.1073/pnas.121007298.PMCID: PMC37443 ATP bound to the origin recognition complex is important for preRC formation Richard D. Klemm and Stephen P. Bell Proc Natl Acad Sci U S A. 2001 July 17; 98(15): 8361–8367. doi: 10.1073/pnas.131006898.PMCID: PMC37444 Creating a dynamic picture of the sliding clamp during T4 DNA polymerase holoenzyme assembly by using fluorescence resonance energy transfer Michael A. Trakselis, Stephen C. Alley, Ernesto Abel-Santos, and Stephen J. Benkovic Proc Natl Acad Sci U S A. 2001 July 17; 98(15): 8368–8375. doi: 10.1073/pnas.111006698.PMCID: PMC37445 Interaction of the β sliding clamp with MutS, ligase, and DNA polymerase I Francisco J. López de Saro and Mike O'Donnell Proc Natl Acad Sci U S A. 2001 July 17; 98(15): 8376–8380. doi: 10.1073/pnas.121009498.PMCID: PMC37446 Defining the roles of individual residues in the single-stranded DNA binding site of PcrA helicase Mark S. Dillingham, Panos Soultanas, Paul Wiley, Martin R. Webb, and Dale B. Wigley Proc Natl Acad Sci U S A. 2001 July 17; 98(15): 8381–8387. doi: 10.1073/pnas.131009598.PMCID: PMC37447 Homologous DNA recombination in vertebrate cells Eiichiro Sonoda, Minoru Takata, Yukiko M. Yamashita, Ciaran Morrison, and Shunichi Takeda Proc Natl Acad Sci U S A. 2001 July 17; 98(15): 8388–8394. doi: 10.1073/pnas.111006398.PMCID: PMC37448 Meiotic recombination and chromosome segregation in Schizosaccharomyces pombe Luther Davis and Gerald R. Smith Proc Natl Acad Sci U S A. 2001 July 17; 98(15): 8395–8402. doi: 10.1073/pnas.121005598.PMCID: PMC37449 Manipulating the mammalian genome by homologous recombination Karen M. Vasquez, Kathleen Marburger, Zsofia Intody, and John H. Wilson Proc Natl Acad Sci U S A. 2001 July 17; 98(15): 8403–8410. doi: 10.1073/pnas.111009698.PMCID: PMC37450 Assembly of RecA-like recombinases: Distinct roles for mediator proteins in mitosis and meiosis Stephen L. Gasior, Heidi Olivares, Uy Ear, Danielle M. Hari, Ralph Weichselbaum, and Douglas K. Bishop Proc Natl Acad Sci U S A. 2001 July 17; 98(15): 8411–8418. doi: 10.1073/pnas.121046198.PMCID: PMC37451 Domain structure and dynamics in the helical filaments formed by RecA and Rad51 on DNA Xiong Yu, Steven A. Jacobs, Stephen C. West, Tomoko Ogawa, and Edward H. Egelman Proc Natl Acad Sci U S A. 2001 July 17; 98(15): 8419–8424. doi: 10.1073/pnas.111005398.PMCID: PMC37452 Homologous genetic recombination as an intrinsic dynamic property of a DNA structure induced by RecA/Rad51-family proteins: A possible advantage of DNA over RNA as genomic material Takehiko Shibata, Taro Nishinaka, Tsutomu Mikawa, Hideki Aihara, Hitoshi Kurumizaka, Shigeyuki Yokoyama, and Yutaka Ito Proc Natl Acad Sci U S A. 2001 July 17; 98(15): 8425–8432. doi: 10.1073/pnas.111005198.PMCID: PMC37453 The synaptic activity of HsDmc1, a human recombination protein specific to meiosis R. C. Gupta, E. Golub, B. Bi, and C. M. Radding Proc Natl Acad Sci U S A. 2001 July 17; 98(15): 8433–8439. doi: 10.1073/pnas.121005298.PMCID: PMC37454 Complex formation by the human RAD51C and XRCC3 recombination repair proteins Jean-Yves Masson, Alicja Z. Stasiak, Andrzej Stasiak, Fiona E. Benson, and Stephen C. West Proc Natl Acad Sci U S A. 2001 July 17; 98(15): 8440–8446. doi: 10.1073/pnas.111005698.PMCID: PMC37455 Rad54 protein stimulates the postsynaptic phase of Rad51
protein-mediated DNA strand exchange Jachen Armon Solinger and Wolf-Dietrich Heyer Proc Natl Acad Sci U S A. 2001 July 17; 98(15): 8447–8453. doi: 10.1073/pnas.121009898.PMCID: PMC37456 The architecture of the human Rad54–DNA complex provides evidence for protein translocation along DNA Dejan Ristic, Claire Wyman, Coen Paulusma, and Roland Kanaar Proc Natl Acad Sci U S A. 2001 July 17; 98(15): 8454–8460. doi: 10.1073/pnas.151056798.PMCID: PMC37457 DNA replication meets genetic exchange: Chromosomal damage and its repair by homologous recombination Andrei Kuzminov Proc Natl Acad Sci U S A. 2001 July 17; 98(15): 8461–8468. doi: 10.1073/pnas.151260698.PMCID: PMC37458 Editorial Unfettered access to published results Nicholas R. Cozzarelli Proc Natl Acad Sci U S A. 2001 July 17; 98(15): 8159. Published online 2001 July 10. doi: 10.1073/pnas.171309098.PMCID: PMC37411 Commentaries Hepcidin: A putative iron-regulatory hormone relevant to hereditary hemochromatosis and the anemia of chronic disease Robert E. Fleming and William S. Sly Proc Natl Acad Sci U S A. 2001 July 17; 98(15): 8160–8162. doi: 10.1073/pnas.161296298.PMCID: PMC37412 Gene galaxies in the maize genome Virginia Walbot and Dmitri A. Petrov Proc Natl Acad Sci U S A. 2001 July 17; 98(15): 8163–8164. doi: 10.1073/pnas.161278798.PMCID: PMC37413 Structural basis for bending tropomyosin around actin in muscle thin filaments Murray Stewart Proc Natl Acad Sci U S A. 2001 July 17; 98(15): 8165–8166. doi: 10.1073/pnas.151265198.PMCID: PMC37414 Dehydroepiandrosterone sulfate and longevity: New clues for an old friend Samuel S. C. Yen Proc Natl Acad Sci U S A. 2001 July 17; 98(15): 8167–8169. doi: 10.1073/pnas.161278698.PMCID: PMC37415 Probing the mechanism of enzymatic phosphoryl transfer with a chemical trick Paul R. Thompson and Philip A. Cole Proc Natl Acad Sci U S A. 2001 July 17; 98(15): 8170–8171. doi: 10.1073/pnas.161273998.PMCID: PMC37416 Physical Sciences Chemistry Single-molecule spectroscopy of the β2 adrenergic receptor: Observation of conformational substates in a membrane protein Gadi Peleg, Pejman Ghanouni, Brian K. Kobilka, and Richard N. Zare Proc Natl Acad Sci U S A. 2001 July 17; 98(15): 8469–8474. Published online 2001 July 3. doi: 10.1073/pnas.151239698.PMCID: PMC37459 The relaxation dynamics of the excited electronic states of retinal in bacteriorhodopsin by two-pump-probe femtosecond studies S. L. Logunov, V. V. Volkov, M. Braun, and M. A. El-Sayed Proc Natl Acad Sci U S A. 2001 July 17; 98(15): 8475–8479. Published online 2001 July 10. doi: 10.1073/pnas.141220198.PMCID: PMC37460 Antibodies with infinite affinity Albert J. Chmura, Molly S. Orton, and Claude F. Meares Proc Natl Acad Sci U S A. 2001 July 17; 98(15): 8480–8484. Published online 2001 July 10. doi: 10.1073/pnas.151260298.PMCID: PMC37461 Physics Tuning DNA “strings”: Modulating the rate of DNA replication with mechanical tension Anita Goel, Maxim D. Frank-Kamenetskii, Tom Ellenberger, and Dudley Herschbach Proc Natl Acad Sci U S A. 2001 July 17; 98(15): 8485–8489. Published online 2001 July 10. doi: 10.1073/pnas.151261198.PMCID: PMC37462 Force and kinetic barriers to unzipping of the DNA double helix Simona Cocco, Rémi Monasson, and John F. Marko Proc Natl Acad Sci U S A. 2001 July 17; 98(15): 8608–8613. Published online 2001 July 10. doi: 10.1073/pnas.151257598.PMCID: PMC37483 Biological Sciences Biochemistry DNA bending by an adenine–thymine tract and its role in gene regulation Jenny Hizver, Haim Rozenberg, Felix Frolow, Dov Rabinovich, and Zippora Shakked Proc Natl Acad Sci U S A. 2001 July 17; 98(15): 8490–8495. Published online 2001 July 3. doi: 10.1073/pnas.151247298.PMCID: PMC37463 Deciphering the design of the tropomyosin molecule Jerry H. Brown, Kyoung-Hee Kim, Gyo Jun, Norma J. Greenfield, Roberto Dominguez, Niels Volkmann, Sarah E. Hitchcock-DeGregori, and Carolyn Cohen Proc Natl Acad Sci U S A. 2001 July 17; 98(15): 8496–8501. Published online 2001 July 3. doi: 10.1073/pnas.131219198.PMCID: PMC37464 The trimer-of-hairpins motif in membrane fusion: Visna virus Vladimir N. Malashkevich, Mona Singh, and Peter S. Kim Proc Natl Acad Sci U S A. 2001 July 17; 98(15): 8502–8506. Published online 2001 July 10. doi: 10.1073/pnas.151254798.PMCID: PMC37465 Solution structure of the 2-amino-1- methyl-6-phenylimidazo[4,5-b]pyridine C8-deoxyguanosine adduct in duplex DNA Karen Brown, Brian E. Hingerty, Elizabeth A. Guenther, V. V. Krishnan, Suse Broyde, Kenneth W. Turteltaub, and Monique Cosman Proc Natl Acad Sci U S A. 2001 July 17; 98(15): 8507–8512. Published online 2001 July 3. doi: 10.1073/pnas.151251898.PMCID: PMC37466 Biosynthesis of the thiazole moiety of thiamin in Escherichia coli: Identification of an acyldisulfide-linked protein–protein conjugate that is functionally analogous to the ubiquitin/E1 complex Jun Xi, Ying Ge, Cynthia Kinsland, Fred W. McLafferty, and Tadhg P. Begley Proc Natl Acad Sci U S A. 2001 July 17; 98(15): 8513–8518. Published online 2001 July 3. doi: 10.1073/pnas.141226698.PMCID: PMC37467 Energy-driven subunit rotation at the interface between subunit a and the c oligomer in the FO sector of Escherichia coli ATP synthase Marcus L. Hutcheon, Thomas M. Duncan, Helen Ngai, and Richard L. Cross Proc Natl Acad Sci U S A. 2001 July 17; 98(15): 8519–8524. Published online 2001 July 3. doi: 10.1073/pnas.151236798.PMCID: PMC37468 From the Cover: BeF acts as a phosphate analog in proteins phosphorylated on aspartate: Structure of a BeF complex with phosphoserine phosphatase Ho Cho, Weiru Wang, Rosalind Kim, Hisao Yokota, Steven Damo, Sung-Hou Kim, David Wemmer, Sydney Kustu, and Dalai Yan Proc Natl Acad Sci U S A. 2001 July 17; 98(15): 8525–8530. Published online 2001 July 3. doi: 10.1073/pnas.131213698.PMCID: PMC37469 Location and properties of metal-binding sites on the human prion protein Graham S. Jackson, Ian Murray, Laszlo L. P. Hosszu, Nicholas Gibbs, Jonathan P. Waltho, Anthony R. Clarke, and John Collinge Proc Natl Acad Sci U S A. 2001 July 17; 98(15): 8531–8535. Published online 2001 July 3. doi: 10.1073/pnas.151038498.PMCID: PMC37470 A mutant cholera toxin B subunit that binds GM1- ganglioside but lacks immunomodulatory or toxic activity A. T. Aman, S. Fraser, E. A. Merritt, C. Rodigherio, M. Kenny, M. Ahn, W. G. J. Hol, N. A. Williams, W. I. Lencer, and T. R. Hirst Proc Natl Acad Sci U S A. 2001 July 17; 98(15): 8536–8541. Published online 2001 July 10. doi: 10.1073/pnas.161273098.PMCID: PMC37471 The endopolyphosphatase gene: Essential in Saccharomyces cerevisiae Anand Sethuraman, Narayana N. Rao, and Arthur Kornberg Proc Natl Acad Sci U S A. 2001 July 17; 98(15): 8542–8547. Published online 2001 July 10. doi: 10.1073/pnas.151269398.PMCID: PMC37472 Molecular cloning and sequence analysis of the complestatin biosynthetic gene cluster Hsien-Tai Chiu, Brian K. Hubbard, Aseema N. Shah, Jonathan Eide, Ross A. Fredenburg, Christopher T. Walsh, and Chaitan Khosla Proc Natl Acad Sci U S A. 2001 July 17; 98(15): 8548–8553. Published online 2001 July 10. doi: 10.1073/pnas.151246498.PMCID: PMC37473 Protacs: Chimeric molecules that target proteins to the Skp1–Cullin–F box complex for ubiquitination and degradation Kathleen M. Sakamoto, Kyung B. Kim, Akiko Kumagai, Frank Mercurio, Craig M. Crews, and Raymond J. Deshaies Proc Natl Acad Sci U S A. 2001 July 17; 98(15): 8554–8559. Published online 2001 July 3. doi: 10.1073/pnas.141230798.PMCID: PMC37474 Old yellow enzyme: Reduction of nitrate esters, glycerin trinitrate, and propylene 1,2-dinitrate Younus Meah, Bette Jo Brown, Sumita Chakraborty, and Vincent Massey Proc Natl Acad Sci U S A. 2001 July 17; 98(15): 8560–8565. Published online 2001 July 3. doi: 10.1073/pnas.151249098.PMCID: PMC37475 Mechanism of DNA polymerase II-mediated frameshift mutagenesis Olivier J. Becherel and Robert P. P. Fuchs Proc Natl Acad Sci U S A. 2001 July 17; 98(15): 8566–8571. Published online 2001 July 10. doi: 10.1073/pnas.141113398.PMCID: PMC37476 In vitro generated antibodies specific for telomeric guanine-quadruplex DNA react with Stylonychia lemnae macronuclei Christiane Schaffitzel, Imre Berger, Jan Postberg, Jozef Hanes, Hans J. Lipps, and Andreas Plückthun Proc Natl Acad Sci U S A. 2001 July 17; 98(15): 8572–8577. Published online 2001 July 3. doi: 10.1073/pnas.141229498.PMCID: PMC37477 Critical role for the docking-protein FRS2α in FGF receptor-mediated signal transduction pathways Y. R. Hadari, N. Gotoh, H. Kouhara, I. Lax, and J. Schlessinger Proc Natl Acad Sci U S A. 2001 July 17; 98(15): 8578–8583. Published online 2001 July 10. doi: 10.1073/pnas.161259898.PMCID: PMC37478 Sir3-dependent assembly of supramolecular chromatin structures in vitro Philippe T. Georgel, Madeleine A. Palacios DeBeer, Gregory Pietz, Catherine A. Fox, and Jeffrey C. Hansen Proc Natl Acad Sci U S A. 2001 July 17; 98(15): 8584–8589. Published online 2001 July 10. doi: 10.1073/pnas.151258798.PMCID: PMC37479 Multiple vesiculoviral matrix proteins inhibit both nuclear export and import Jeannine M. Petersen, Lu-Shiun Her, and James E. Dahlberg Proc Natl Acad Sci U S A. 2001 July 17; 98(15): 8590–8595. Published online 2001 July 10. doi: 10.1073/pnas.151240998.PMCID: PMC37480 Physical and functional interactions between Drosophila TRAF2 and Pelle kinase contribute to Dorsal activation Baohe Shen, H. Liu, Edward Y. Skolnik, and James L. Manley Proc Natl Acad Sci U S A. 2001 July 17; 98(15): 8596–8601. Published online 2001 July 10. doi: 10.1073/pnas.141235698.PMCID: PMC37481 Biophysics The relaxation dynamics of the excited electronic states of retinal in bacteriorhodopsin by two-pump-probe femtosecond studies S. L. Logunov, V. V. Volkov, M. Braun, and M. A. El-Sayed Proc Natl Acad Sci U S A. 2001 July 17; 98(15): 8475–8479. Published online 2001 July 10. doi: 10.1073/pnas.141220198.PMCID: PMC37460 Tuning DNA “strings”: Modulating the rate of DNA replication with mechanical tension Anita Goel, Maxim D. Frank-Kamenetskii, Tom Ellenberger, and Dudley Herschbach Proc Natl Acad Sci U S A. 2001 July 17; 98(15): 8485–8489. Published online 2001 July 10. doi: 10.1073/pnas.151261198.PMCID: PMC37462 Excited-state dynamics in photosystem II: Insights from the
x-ray crystal structure Sergej Vasil'ev, Peter Orth, Athina Zouni, Thomas G. Owens, and Doug Bruce Proc Natl Acad Sci U S A. 2001 July 17; 98(15): 8602–8607. doi: 10.1073/pnas.141239598.PMCID: PMC37482 Force and kinetic barriers to unzipping of the DNA double helix Simona Cocco, Rémi Monasson, and John F. Marko Proc Natl Acad Sci U S A. 2001 July 17; 98(15): 8608–8613. Published online 2001 July 10. doi: 10.1073/pnas.151257598.PMCID: PMC37483 Intrinsic noise in gene regulatory networks Mukund Thattai and Alexander van Oudenaarden Proc Natl Acad Sci U S A. 2001 July 17; 98(15): 8614–8619. Published online 2001 July 3. doi: 10.1073/pnas.151588598.PMCID: PMC37484 Computer-modeling origin of a simple genetic apparatus Christoph Kuhn Proc Natl Acad Sci U S A. 2001 July 17; 98(15): 8620–8625. doi: 10.1073/pnas.141379398.PMCID: PMC37485 Cell Biology Telomerase expression and activity are coupled with myocyte proliferation and preservation of telomeric length in the failing heart Annarosa Leri, Laura Barlucchi, Federica Limana, Andrzej Deptala, Zbigniew Darzynkiewicz, Thomas H. Hintze, Jan Kajstura, Bernardo Nadal-Ginard, and Piero Anversa Proc Natl Acad Sci U S A. 2001 July 17; 98(15): 8626–8631. Published online 2001 July 10. doi: 10.1073/pnas.151013298.PMCID: PMC37486 Contact interactions between epitheliocytes and fibroblasts: Formation of heterotypic cadherin-containing adhesion sites is accompanied by local cytoskeletal reorganization T. Omelchenko, E. Fetisova, O. Ivanova, E. M. Bonder, H. Feder, J. M. Vasiliev, and I. M. Gelfand Proc Natl Acad Sci U S A. 2001 July 17; 98(15): 8632–8637. Published online 2001 July 10. doi: 10.1073/pnas.151247698.PMCID: PMC37487 Complex regulation of human inducible nitric oxide synthase gene transcription by Stat 1 and NF-κB Raymond W. Ganster, Bradley S. Taylor, Lifang Shao, and David A. Geller Proc Natl Acad Sci U S A. 2001 July 17; 98(15): 8638–8643. Published online 2001 July 3. doi: 10.1073/pnas.151239498.PMCID: PMC37488 Deficiency of human BRCA2 leads to impaired homologous recombination but maintains normal nonhomologous end joining Fen Xia, Danielle G. Taghian, Jeffrey S. DeFrank, Zhao-Chong Zeng, Henning Willers, George Iliakis, and Simon N. Powell Proc Natl Acad Sci U S A. 2001 July 17; 98(15): 8644–8649. Published online 2001 July 10. doi: 10.1073/pnas.151253498.PMCID: PMC37489 Subnuclear targeting of Runx/Cbfa/AML factors is essential for tissue-specific differentiation during embryonic development Je-Yong Choi, Jitesh Pratap, Amjad Javed, S. Kaleem Zaidi, Lianping Xing, Eva Balint, Sara Dalamangas, Brendan Boyce, André J. van Wijnen, Jane B. Lian, Janet L. Stein, Stephen N. Jones, and Gary S. Stein Proc Natl Acad Sci U S A. 2001 July 17; 98(15): 8650–8655. Published online 2001 July 3. doi: 10.1073/pnas.151236498.PMCID: PMC37490 Antagonistic forces generated by myosin II and cytoplasmic dynein regulate microtubule turnover, movement, and organization in interphase cells Anne-Marie C. Yvon, David J. Gross, and Patricia Wadsworth Proc Natl Acad Sci U S A. 2001 July 17; 98(15): 8656–8661. Published online 2001 July 3. doi: 10.1073/pnas.141224198.PMCID: PMC37491 Ubiquitin-protein ligase activity of X-linked inhibitor of apoptosis protein promotes proteasomal degradation of caspase-3 and enhances its anti-apoptotic effect in Fas-induced cell death Yasuyuki Suzuki, Yui Nakabayashi, and Ryosuke Takahashi Proc Natl Acad Sci U S A. 2001 July 17; 98(15): 8662–8667. Published online 2001 July 10. doi: 10.1073/pnas.161506698.PMCID: PMC37492 Developmental Biology Rescue of a Wnt mutation by an activated form of LEF-1: Regulation of maintenance but not initiation of Brachyury expression Juan Galceran, Shu-Chi Hsu, and Rudolf Grosschedl Proc Natl Acad Sci U S A. 2001 July 17; 98(15): 8668–8673. Published online 2001 July 10. doi: 10.1073/pnas.151258098.PMCID: PMC37493 Tbx19, a tissue-selective regulator of POMC gene expression Jianxiang Liu, Chijen Lin, Anatoli Gleiberman, Kenneth A. Ohgi, Thomas Herman, Hsiang-Po Huang, Ming-Jer Tsai, and Michael G. Rosenfeld Proc Natl Acad Sci U S A. 2001 July 17; 98(15): 8674–8679. Published online 2001 July 10. doi: 10.1073/pnas.141234898.PMCID: PMC37494 Dual control of LIF expression and LIF receptor function regulate Stat3 activation at the onset of uterine receptivity and embryo implantation Jr-Gang Cheng, Jim Ray Chen, Lidia Hernandez, W. Greg Alvord, and Colin L. Stewart Proc Natl Acad Sci U S A. 2001 July 17; 98(15): 8680–8685. Published online 2001 July 3. doi: 10.1073/pnas.151180898.PMCID: PMC37495 Use of cDNA subtraction and RNA interference screens in combination reveals genes required for germ-line development in Caenorhabditis elegans Momoyo Hanazawa, Makoto Mochii, Naoto Ueno, Yuji Kohara, and Yuichi Iino Proc Natl Acad Sci U S A. 2001 July 17; 98(15): 8686–8691. Published online 2001 July 10. doi: 10.1073/pnas.141004698.PMCID: PMC37496 Evolution Sexually antagonistic coevolution of a postmating-prezygotic reproductive character in desert Drosophila L. Lacey Knowles and Therese A. Markow Proc Natl Acad Sci U S A. 2001 July 17; 98(15): 8692–8696. Published online 2001 July 10. doi: 10.1073/pnas.151123998.PMCID: PMC37497 Genetics Somatic mosaicism in Wiskott–Aldrich syndrome suggests in vivo reversion by a DNA slippage mechanism Taizo Wada, Shepherd H. Schurman, Makoto Otsu, Elizabeth K. Garabedian, Hans D. Ochs, David L. Nelson, and Fabio Candotti Proc Natl Acad Sci U S A. 2001 July 17; 98(15): 8697–8702. Published online 2001 July 10. doi: 10.1073/pnas.151260498.PMCID: PMC37498 Identification of an autoimmune serum containing antibodies against the Barr body Bo Hong, Peter Reeves, Barbara Panning, Maurice S. Swanson, and Thomas P. Yang Proc Natl Acad Sci U S A. 2001 July 17; 98(15): 8703–8708. Published online 2001 July 3. doi: 10.1073/pnas.151259598.PMCID: PMC37499 An antisense approach to phenotype-based gene cloning in Tetrahymena N. Doane Chilcoat, Nels C. Elde, and Aaron P. Turkewitz Proc Natl Acad Sci U S A. 2001 July 17; 98(15): 8709–8713. Published online 2001 July 3. doi: 10.1073/pnas.151243498.PMCID: PMC37500 Rolling-circle transposons in eukaryotes Vladimir V. Kapitonov and Jerzy Jurka Proc Natl Acad Sci U S A. 2001 July 17; 98(15): 8714–8719. Published online 2001 July 10. doi: 10.1073/pnas.151269298.PMCID: PMC37501 Histone deacetylase-dependent transcriptional repression by pRB in yeast occurs independently of interaction through the LXCXE binding cleft Brian K. Kennedy, Oliver W. Liu, Fred A. Dick, Nick Dyson, Ed Harlow, and Marc Vidal Proc Natl Acad Sci U S A. 2001 July 17; 98(15): 8720–8725. Published online 2001 July 10. doi: 10.1073/pnas.151240898.PMCID: PMC37502 A two-hybrid system for transactivator bait proteins Martin Hirst, Cynthia Ho, Luc Sabourin, Michael Rudnicki, Linda Penn, and Ivan Sadowski Proc Natl Acad Sci U S A. 2001 July 17; 98(15): 8726–8731. Published online 2001 July 10. doi: 10.1073/pnas.141413598.PMCID: PMC37503 Immunology IL-7 is critical for homeostatic proliferation and survival of naïve T cells Joyce T. Tan, Eric Dudl, Eric LeRoy, Richard Murray, Jonathan Sprent, Kenneth I. Weinberg, and Charles D. Surh Proc Natl Acad Sci U S A. 2001 July 17; 98(15): 8732–8737. Published online 2001 July 10. doi: 10.1073/pnas.161126098.PMCID: PMC37504 Regulatory function of in vivo anergized CD4+ T cells Karin Jooss, Bernard Gjata, Olivier Danos, Harald von Boehmer, and Adelaida Sarukhan Proc Natl Acad Sci U S A. 2001 July 17; 98(15): 8738–8743. Published online 2001 July 3. doi: 10.1073/pnas.151088898.PMCID: PMC37505 How αβ T cells deal with induced TCRα ablation Bojan Polic, Desiree Kunkel, Alexander Scheffold, and Klaus Rajewsky Proc Natl Acad Sci U S A. 2001 July 17; 98(15): 8744–8749. Published online 2001 July 10. doi: 10.1073/pnas.141218898.PMCID: PMC37506 A role for CD36 in the regulation of dendritic cell function Britta C. Urban, Nick Willcox, and David J. Roberts Proc Natl Acad Sci U S A. 2001 July 17; 98(15): 8750–8755. Published online 2001 July 10. doi: 10.1073/pnas.151028698.PMCID: PMC37507 Medical Sciences The human formin-binding protein 17 (FBP17) interacts with sorting nexin, SNX2, and is an MLL-fusion partner in acute myelogeneous leukemia Uta Fuchs, Gönna Rehkamp, Oskar A. Haas, Robert Slany, Margit König, Stig Bojesen, Rainer M. Bohle, Christine Damm-Welk, Wolf-Dieter Ludwig, Jochen Harbott, and Arndt Borkhardt Proc Natl Acad Sci U S A. 2001 July 17; 98(15): 8756–8761. Published online 2001 July 3. doi: 10.1073/pnas.121433898.PMCID: PMC37508 A germ-line Tsc1 mutation causes tumor development and embryonic lethality that are similar, but not identical to, those caused by Tsc2 mutation in mice Toshiyuki Kobayashi, Osamu Minowa, Yoshinobu Sugitani, Setsuo Takai, Hiroaki Mitani, Etsuko Kobayashi, Tetsuo Noda, and Okio Hino Proc Natl Acad Sci U S A. 2001 July 17; 98(15): 8762–8767. Published online 2001 July 3. doi: 10.1073/pnas.151033798.PMCID: PMC37509 Demonstration of the extrinsic coagulation pathway in teleostei: Identification of zebrafish coagulation factor VII John Sheehan, Michael Templer, Michael Gregory, Ravikumar Hanumanthaiah, Dean Troyer, Thao Phan, Bharath Thankavel, and Pudur Jagadeeswaran Proc Natl Acad Sci U S A. 2001 July 17; 98(15): 8768–8773. doi: 10.1073/pnas.131109398.PMCID: PMC37510 Activation of NF-κB by nontypeable Hemophilus influenzae is mediated by toll-like receptor 2-TAK1-dependent NIK–IKKα/β–IκBα and MKK3/6–p38 MAP kinase signaling pathways in epithelial cells Tsuyoshi Shuto, Haidong Xu, Beinan Wang, Jiahuai Han, Hirofumi Kai, Xin-Xing Gu, Timothy F. Murphy, David J. Lim, and Jian-Dong Li Proc Natl Acad Sci U S A. 2001 July 17; 98(15): 8774–8779. Published online 2001 July 3. doi: 10.1073/pnas.151236098.PMCID: PMC37511 From the Cover: Lack of hepcidin gene expression and severe tissue iron overload in upstream stimulatory factor 2 (USF2) knockout mice Gaël Nicolas, Myriam Bennoun, Isabelle Devaux, Carole Beaumont, Bernard Grandchamp, Axel Kahn, and Sophie Vaulont Proc Natl Acad Sci U S A. 2001 July 17; 98(15): 8780–8785. Published online 2001 July 10. doi: 10.1073/pnas.151179498.PMCID: PMC37512 TAT peptide on the surface of liposomes affords their efficient intracellular delivery even at low temperature and in the presence of metabolic inhibitors Vladimir P. Torchilin, Ram Rammohan, Volkmar Weissig, and Tatyana S. Levchenko Proc Natl Acad Sci U S A. 2001 July 17; 98(15): 8786–8791. Published online 2001 July 3. doi: 10.1073/pnas.151247498.PMCID: PMC37513 Altered potassium balance and aldosterone secretion in a mouse model of human congenital long QT syndrome Isabelle Arrighi, May Bloch-Faure, Florian Grahammer, Markus Bleich, Richard Warth, Raymond Mengual, Milou-Daniel Drici, Jacques Barhanin, and Pierre Meneton Proc Natl Acad Sci U S A. 2001 July 17; 98(15): 8792–8797. Published online 2001 July 3. doi: 10.1073/pnas.141233398.PMCID: PMC37514 Targeted expression of heme oxygenase-1 prevents the pulmonary inflammatory and vascular responses to hypoxia Tohru Minamino, Helen Christou, Chung-Ming Hsieh, Yuxiang Liu, Vijender Dhawan, Nader G. Abraham, Mark A. Perrella, S. Alex Mitsialis, and Stella Kourembanas Proc Natl Acad Sci U S A. 2001 July 17; 98(15): 8798–8803. Published online 2001 July 10. doi: 10.1073/pnas.161272598.PMCID: PMC37515 Enhanced antitumor efficacy of a herpes simplex virus mutant isolated by genetic selection in cancer cells Samir Taneja, Jennifer MacGregor, Steven Markus, Susan Ha, and Ian Mohr Proc Natl Acad Sci U S A. 2001 July 17; 98(15): 8804–8808. Published online 2001 July 3. doi: 10.1073/pnas.161011798.PMCID: PMC37516 Altered peptide ligand vaccination with Flt3 ligand expanded dendritic cells for tumor immunotherapy Lawrence Fong, Yafei Hou, Alberto Rivas, Claudia Benike, Alan Yuen, George A. Fisher, Mark M. Davis, and Edgar G. Engleman Proc Natl Acad Sci U S A. 2001 July 17; 98(15): 8809–8814. Published online 2001 June 26. doi: 10.1073/pnas.141226398.PMCID: PMC37517 Microbiology The infected cell protein 0 of herpes simplex virus 1 dynamically interacts with proteasomes, binds and activates the cdc34 E2 ubiquitin-conjugating enzyme, and possesses in vitro E3 ubiquitin ligase activity Charles Van Sant, Ryan Hagglund, Pascal Lopez, and Bernard Roizman Proc Natl Acad Sci U S A. 2001 July 17; 98(15): 8815–8820. Published online 2001 July 10. doi: 10.1073/pnas.161283098.PMCID: PMC37518 Evolutionary genomics of Staphylococcus aureus: Insights into the origin of methicillin-resistant strains and the toxic shock syndrome epidemic J. Ross Fitzgerald, Daniel E. Sturdevant, Stacy M. Mackie, Steven R. Gill, and James M. Musser Proc Natl Acad Sci U S A. 2001 July 17; 98(15): 8821–8826. Published online 2001 July 10. doi: 10.1073/pnas.161098098.PMCID: PMC37519 Neurobiology Lightness constancy in primary visual cortex Sean P. MacEvoy and Michael A. Paradiso Proc Natl Acad Sci U S A. 2001 July 17; 98(15): 8827–8831. Published online 2001 July 10. doi: 10.1073/pnas.161280398.PMCID: PMC37520 Rapid induction of intraneuronal neurofibrillary tangles in apolipoprotein E-deficient mice Xiaoning Bi, Alex P. Yong, Jun Zhou, Charles E. Ribak, and Gary Lynch Proc Natl Acad Sci U S A. 2001 July 17; 98(15): 8832–8837. Published online 2001 July 3. doi: 10.1073/pnas.151253098.PMCID: PMC37521 Apolipoprotein E fragments present in Alzheimer's disease brains induce neurofibrillary tangle-like intracellular inclusions in neurons Yadong Huang, Xiao Qin Liu, Tony Wyss-Coray, Walter J. Brecht, David A. Sanan, and Robert W. Mahley Proc Natl Acad Sci U S A. 2001 July 17; 98(15): 8838–8843. Published online 2001 July 10. doi: 10.1073/pnas.151254698.PMCID: PMC37522 A highly conserved protein family interacting with the fragile X mental retardation protein (FMRP) and displaying selective interactions with FMRP-related proteins FXR1P and FXR2P Annette Schenck, Barbara Bardoni, Annamaria Moro, Claudia Bagni, and Jean-Louis Mandel Proc Natl Acad Sci U S A. 2001 July 17; 98(15): 8844–8849. Published online 2001 July 3. doi: 10.1073/pnas.151231598.PMCID: PMC37523 Peripheral anti-Aβ antibody alters CNS and plasma Aβ clearance and decreases brain Aβ burden in a mouse model of Alzheimer's disease Ronald B. DeMattos, Kelly R. Bales, David J. Cummins, Jean-Cosme Dodart, Steven M. Paul, and David M. Holtzman Proc Natl Acad Sci U S A. 2001 July 17; 98(15): 8850–8855. Published online 2001 July 3. doi: 10.1073/pnas.151261398.PMCID: PMC37524 Long-term, progressive hippocampal cell loss and dysfunction induced by early-life administration of corticotropin-releasing hormone reproduce the effects of early-life stress Kristen L. Brunson, Mariam Eghbal-Ahmadi, Roland Bender, Yuncai Chen, and Tallie Z. Baram Proc Natl Acad Sci U S A. 2001 July 17; 98(15): 8856–8861. Published online 2001 July 10. doi: 10.1073/pnas.151224898.PMCID: PMC37525 Genome-wide gene expression profiles of the developing mouse hippocampus Monica Mody, Yanxiang Cao, Zhenzhong Cui, Khoon-Yen Tay, Andy Shyong, Eiji Shimizu, Kelvin Pham, Peter Schultz, Douglas Welsh, and Joe Z. Tsien Proc Natl Acad Sci U S A. 2001 July 17; 98(15): 8862–8867. Published online 2001 July 3. doi: 10.1073/pnas.141244998.PMCID: PMC37526 Dominant loss of responsiveness to sweet and bitter compounds caused by a single mutation in α-gustducin Luis Ruiz-Avila, Gwendolyn T. Wong, Sami Damak, and Robert F. Margolskee Proc Natl Acad Sci U S A. 2001 July 17; 98(15): 8868–8873. Published online 2001 July 10. doi: 10.1073/pnas.151235798.PMCID: PMC37527 Long-term plasticity in interneurons of the dentate gyrus Stephen T. Ross and Ivan Soltesz Proc Natl Acad Sci U S A. 2001 July 17; 98(15): 8874–8879. Published online 2001 July 3. doi: 10.1073/pnas.141042398.PMCID: PMC37528 Pharmacology 4-Hydroxytamoxifen binds to and deactivates the estrogen-related receptor γ Peter Coward, Doris Lee, Mitchell V. Hull, and Jürgen M. Lehmann Proc Natl Acad Sci U S A. 2001 July 17; 98(15): 8880–8884. Published online 2001 July 10. doi: 10.1073/pnas.151244398.PMCID: PMC37529 Physiology Prostaglandins are required for CREB activation and cellular proliferation during liver regeneration David A. Rudnick, David H. Perlmutter, and Louis J. Muglia Proc Natl Acad Sci U S A. 2001 July 17; 98(15): 8885–8890. Published online 2001 July 10. doi: 10.1073/pnas.151217998.PMCID: PMC37530 Folliculostellate cell network: A route for long-distance communication in the anterior pituitary Teddy Fauquier, Nathalie C. Guérineau, R. Anne McKinney, Karl Bauer, and Patrice Mollard Proc Natl Acad Sci U S A. 2001 July 17; 98(15): 8891–8896. Published online 2001 July 3. doi: 10.1073/pnas.151339598.PMCID: PMC37531 NCX-1000, a NO-releasing derivative of ursodeoxycholic acid, selectively delivers NO to the liver and protects against development of portal hypertension Stefano Fiorucci, Elisabetta Antonelli, Olivia Morelli, Andrea Mencarelli, Alessandro Casini, Tommaso Mello, Barbara Palazzetti, Dominique Tallet, Piero del Soldato, and Antonio Morelli Proc Natl Acad Sci U S A. 2001 July 17; 98(15): 8897–8902. Published online 2001 July 10. doi: 10.1073/pnas.151136298.PMCID: PMC37532 Plant Biology From the Cover: The highly recombinogenic bz locus lies in an unusually gene-rich region of the maize genome Huihua Fu, Wonkeun Park, Xianghe Yan, Zhenwei Zheng, Binzhang Shen, and Hugo K. Dooner Proc Natl Acad Sci U S A. 2001 July 17; 98(15): 8903–8908. Published online 2001 July 3. doi: 10.1073/pnas.141221898.PMCID: PMC37533 Cloning and functional analysis of two gibberellin 3β-hydroxylase genes that are differently expressed during the growth of rice Hironori Itoh, Miyako Ueguchi-Tanaka, Naoki Sentoku, Hidemi Kitano, Makoto Matsuoka, and Masatomo Kobayashi Proc Natl Acad Sci U S A. 2001 July 17; 98(15): 8909–8914. Published online 2001 July 3. doi: 10.1073/pnas.141239398.PMCID: PMC37534 From the Cover: Metabolic engineering of essential oil yield and composition in mint by altering expression of deoxyxylulose phosphate reductoisomerase and menthofuran synthase Soheil S. Mahmoud and Rodney B. Croteau Proc Natl Acad Sci U S A. 2001 July 17; 98(15): 8915–8920. Published online 2001 June 26. doi: 10.1073/pnas.141237298.PMCID: PMC37535 Correction Correction Wojciech Rzeski, Lechoslaw Turski, and Chrysanthy Ikonomidou Proc Natl Acad Sci U S A. 2001 July 17; 98(15): 8921. Published online 2001 July 10. PMCID: PMC55970 Corrects: Wojciech Rzeski, et al. From the Cover: Glutamate antagonists limit tumor growth. Proc Natl Acad Sci U S A. 2001 May 22; 98(11): 6372–6377. |