| | This journal provides immediate access to some articles. Commentaries Coincidence detection enhances appropriate wiring of the nervous system Nicholas C. Spitzer Proc Natl Acad Sci U S A. 2004 April 13; 101(15): 5311–5312. Published online 2004 April 5. doi: 10.1073/pnas.0401270101.PMCID: PMC397370 Silence of the genes Oded Singer, Amiel Yanai, and Inder M. Verma Proc Natl Acad Sci U S A. 2004 April 13; 101(15): 5313–5314. Published online 2004 April 5. doi: 10.1073/pnas.0401209101.PMCID: PMC399310 Asymmetric Catalysis Special Feature Part I Research Articles O-nitroso aldol synthesis: Catalytic enantioselective route to α-aminooxy carbonyl compounds via enamine intermediate Norie Momiyama, Hiromi Torii, Susumu Saito, and Hisashi Yamamoto Proc Natl Acad Sci U S A. 2004 April 13; 101(15): 5374–5378. Published online 2004 April 5. doi: 10.1073/pnas.0307785101.PMCID: PMC397388 Mechanistic studies of the molybdenum-catalyzed asymmetric alkylation reaction David L. Hughes, Guy C. Lloyd-Jones, Shane W. Krska, Laure Gouriou, Veronique D. Bonnet, Kevin Jack, Yongkui Sun, David J. Mathre, and Robert A. Reamer Proc Natl Acad Sci U S A. 2004 April 13; 101(15): 5379–5384. Published online 2004 March 31. doi: 10.1073/pnas.0306918101.PMCID: PMC397389 Asymmetric hydrogenation of α,β-unsaturated phosphonates with Rh-BisP* and Rh-MiniPHOS catalysts: Scope and mechanism of the reaction Ilya D. Gridnev, Masaya Yasutake, Tsuneo Imamoto, and Irina P. Beletskaya Proc Natl Acad Sci U S A. 2004 April 13; 101(15): 5385–5390. Published online 2004 March 15. doi: 10.1073/pnas.0306993101.PMCID: PMC397390 Asymmetric hetero-Diels–Alder reaction catalyzed by dirhodium(II) carboxamidates Michael P. Doyle, Marcela Valenzuela, and Penglin Huang Proc Natl Acad Sci U S A. 2004 April 13; 101(15): 5391–5395. Published online 2004 April 1. doi: 10.1073/pnas.0307025101.PMCID: PMC397391 An efficient, palladium-catalyzed, enantioselective synthesis of (2R)-3-butene-1,2-diol and its use in highly selective Heck reactions Natasha Cheeseman, Martin Fox, Mark Jackson, Ian C. Lennon, and Graham Meek Proc Natl Acad Sci U S A. 2004 April 13; 101(15): 5396–5399. Published online 2004 February 11. doi: 10.1073/pnas.0307047101.PMCID: PMC397392 OH–Pd(0) interaction as a stabilizing factor in palladium-catalyzed allylic alkylations Kristina Hallman, Anders Frölander, Tebikie Wondimagegn, Mats Svensson, and Christina Moberg Proc Natl Acad Sci U S A. 2004 April 13; 101(15): 5400–5404. Published online 2004 April 5. doi: 10.1073/pnas.0307084101.PMCID: PMC397393 Catalytic asymmetric addition of diorganozinc reagents to N-phosphinoylalkylimines Alexandre Côté, Alessandro A. Boezio, and André B. Charette Proc Natl Acad Sci U S A. 2004 April 13; 101(15): 5405–5410. Published online 2004 April 2. doi: 10.1073/pnas.0307096101.PMCID: PMC397394 New biphenol-based, fine-tunable monodentate phosphoramidite ligands for catalytic asymmetric transformations Zihao Hua, Victor C. Vassar, Hojae Choi, and Iwao Ojima Proc Natl Acad Sci U S A. 2004 April 13; 101(15): 5411–5416. Published online 2004 March 12. doi: 10.1073/pnas.0307101101.PMCID: PMC397395 Highly enantioselective alkyne additions to aldehydes in the presence of 1,1′-bi-2-naphthol and hexamethylphosphoramide Ge Gao, Ru-Gang Xie, and Lin Pu Proc Natl Acad Sci U S A. 2004 April 13; 101(15): 5417–5420. Published online 2004 March 16. doi: 10.1073/pnas.0307136101.PMCID: PMC397396 Desymmetrization of enone-diones via rhodium-catalyzed diastereo- and enantioselective tandem conjugate addition-aldol cyclization Brian M. Bocknack, Long-Cheng Wang, and Michael J. Krische Proc Natl Acad Sci U S A. 2004 April 13; 101(15): 5421–5424. Published online 2004 March 15. doi: 10.1073/pnas.0307120101.PMCID: PMC397397 Catalytic asymmetric addition of diphenylzinc to cyclic α,β-unsaturated ketones Hongmei Li, Celina García, and Patrick J. Walsh Proc Natl Acad Sci U S A. 2004 April 13; 101(15): 5425–5427. Published online 2004 April 5. doi: 10.1073/pnas.0307119101.PMCID: PMC397398 Solid-phase synthesis of chiral 3,4-diazaphospholanes and their application to catalytic asymmetric allylic alkylation Clark R. Landis and Thomas P. Clark Proc Natl Acad Sci U S A. 2004 April 13; 101(15): 5428–5432. Published online 2004 February 25. doi: 10.1073/pnas.0307572100.PMCID: PMC397399 Enantioselective syntheses and biological studies of aeruginosin 298-A and its analogs: Application of catalytic asymmetric phase-transfer reaction Yuhei Fukuta, Takashi Ohshima, Vijay Gnanadesikan, Tomoyuki Shibuguchi, Tetsuhiro Nemoto, Takaya Kisugi, Tatsufumi Okino, and Masakatsu Shibasaki Proc Natl Acad Sci U S A. 2004 April 13; 101(15): 5433–5438. Published online 2004 March 2. doi: 10.1073/pnas.0307154101.PMCID: PMC397400 Chiral phosphoramide-catalyzed, enantioselective, directed cross-aldol reactions of aldehydes Scott E. Denmark and Tommy Bui Proc Natl Acad Sci U S A. 2004 April 13; 101(15): 5439–5444. Published online 2004 April 5. doi: 10.1073/pnas.0307212101.PMCID: PMC397401 Mechanistic studies on the catalytic cycle of rhodium-catalyzed asymmetric 1,4-addition of aryltitanate reagents to α,β-unsaturated ketones Norihito Tokunaga, Kazuhiro Yoshida, and Tamio Hayashi Proc Natl Acad Sci U S A. 2004 April 13; 101(15): 5445–5449. Published online 2004 February 23. doi: 10.1073/pnas.0307260101.PMCID: PMC397402 Catalytic enantioselective intermolecular cycloadditions of 2-diazo-3,6-diketoester-derived carbonyl ylides with alkene dipolarophiles David M. Hodgson, Tobias Brückl, Rebecca Glen, Agnès H. Labande, Deborah A. Selden, Alexander G. Dossetter, and Alison J. Redgrave Proc Natl Acad Sci U S A. 2004 April 13; 101(15): 5450–5454. Published online 2004 March 22. doi: 10.1073/pnas.0307274101.PMCID: PMC397403 Rhodium-catalyzed asymmetric ring opening reactions of oxabicyclic alkenes: Catalyst and substrate studies leading to a mechanistic working model Mark Lautens and Keith Fagnou Proc Natl Acad Sci U S A. 2004 April 13; 101(15): 5455–5460. Published online 2004 April 5. doi: 10.1073/pnas.0307271101.PMCID: PMC397404 Helically chiral polymers: A class of ligands for asymmetric catalysis Michael Reggelin, Sebastian Doerr, Martin Klussmann, Melanie Schultz, and Michael Holbach Proc Natl Acad Sci U S A. 2004 April 13; 101(15): 5461–5466. Published online 2004 March 30. doi: 10.1073/pnas.0307443101.PMCID: PMC397405 Effect of sulfide structure on enantioselectivity in catalytic asymmetric epoxidation of aldehydes: Mechanistic insights and implications Varinder K. Aggarwal, Jonathan Charmant, Leo Dudin, Marina Porcelloni, and Jeffery Richardson Proc Natl Acad Sci U S A. 2004 April 13; 101(15): 5467–5471. Published online 2004 March 19. doi: 10.1073/pnas.0307559101.PMCID: PMC397406 Catalytic asymmetric reactions for organic synthesis: The combined C—H activation/Cope rearrangement Huw M. L. Davies and Qihui Jin Proc Natl Acad Sci U S A. 2004 April 13; 101(15): 5472–5475. Published online 2004 March 15. doi: 10.1073/pnas.0307556101.PMCID: PMC397407 Air-stable, storable, and highly efficient chiral zirconium catalysts for enantioselective Mannich-type, aza Diels–Alder, aldol, and hetero Diels–Alder reactions Shū Kobayashi, Masaharu Ueno, Susumu Saito, Yumiko Mizuki, Haruro Ishitani, and Yasuhiro Yamashita Proc Natl Acad Sci U S A. 2004 April 13; 101(15): 5476–5481. Published online 2004 April 5. doi: 10.1073/pnas.0307870101.PMCID: PMC397408 From the Cover: Asymmetric Catalysis Special Feature Part I: Enantioselective organocatalytic construction of pyrroloindolines by a cascade addition–cyclization strategy: Synthesis of (–)-flustramine B Joel F. Austin, Sung-Gon Kim, Christopher J. Sinz, Wen-Jing Xiao, and David W. C. MacMillan Proc Natl Acad Sci U S A. 2004 April 13; 101(15): 5482–5487. Published online 2004 April 5. doi: 10.1073/pnas.0308177101.PMCID: PMC397409 Editorial Asymmetric Catalysis Jack Halpern and Barry M. Trost Proc Natl Acad Sci U S A. 2004 April 13; 101(15): 5347. doi: 10.1073/pnas.0401811101.PMCID: PMC397383 Perspective Asymmetric catalysis: An enabling science Barry M. Trost Proc Natl Acad Sci U S A. 2004 April 13; 101(15): 5348–5355. Published online 2004 February 27. doi: 10.1073/pnas.0306715101.PMCID: PMC397384 Toward efficient asymmetric hydrogenation: Architectural and functional engineering of chiral molecular catalysts Ryoji Noyori, Masato Kitamura, and Takeshi Ohkuma Proc Natl Acad Sci U S A. 2004 April 13; 101(15): 5356–5362. Published online 2004 March 19. doi: 10.1073/pnas.0307928100.PMCID: PMC397385 Catalytic asymmetric synthesis of all-carbon quaternary stereocenters Christopher J. Douglas and Larry E. Overman Proc Natl Acad Sci U S A. 2004 April 13; 101(15): 5363–5367. Published online 2004 January 14. doi: 10.1073/pnas.0307113101.PMCID: PMC397386 Asymmetric catalysis in complex target synthesis Mark S. Taylor and Eric N. Jacobsen Proc Natl Acad Sci U S A. 2004 April 13; 101(15): 5368–5373. Published online 2004 March 12. doi: 10.1073/pnas.0307893101.PMCID: PMC397387 From the Cover: ASYMMETRIC CATALYSIS SPECIAL FEATURE PART I From the Cover: Asymmetric Catalysis Special Feature Part I: Enantioselective organocatalytic construction of pyrroloindolines by a cascade addition–cyclization strategy: Synthesis of (–)-flustramine B Joel F. Austin, Sung-Gon Kim, Christopher J. Sinz, Wen-Jing Xiao, and David W. C. MacMillan Proc Natl Acad Sci U S A. 2004 April 13; 101(15): 5482–5487. Published online 2004 April 5. doi: 10.1073/pnas.0308177101.PMCID: PMC397409 Biographies INAUGURAL ARTICLE by a Recently Elected Academy Member: Biography of James L. Van Etten Christen Brownlee Proc Natl Acad Sci U S A. 2004 April 13; 101(15): 5315–5317. Published online 2004 April 5. doi: 10.1073/pnas.0401846101.PMCID: PMC399311 INAUGURAL ARTICLE by a Recently Elected Academy Member: Biography of Zhu Chen David Bradley Proc Natl Acad Sci U S A. 2004 April 13; 101(15): 5325–5327. Published online 2004 April 5. doi: 10.1073/pnas.0401849101.PMCID: PMC399312 INAUGURAL ARTICLE by a Recently Elected Academy Member: Biography of Joseph S. Takahashi Melissa Marino Proc Natl Acad Sci U S A. 2004 April 13; 101(15): 5336–5338. Published online 2004 April 5. doi: 10.1073/pnas.0401895101.PMCID: PMC399313 Physical Sciences Chemistry O-nitroso aldol synthesis: Catalytic enantioselective route to α-aminooxy carbonyl compounds via enamine intermediate Norie Momiyama, Hiromi Torii, Susumu Saito, and Hisashi Yamamoto Proc Natl Acad Sci U S A. 2004 April 13; 101(15): 5374–5378. Published online 2004 April 5. doi: 10.1073/pnas.0307785101.PMCID: PMC397388 Mechanistic studies of the molybdenum-catalyzed asymmetric alkylation reaction David L. Hughes, Guy C. Lloyd-Jones, Shane W. Krska, Laure Gouriou, Veronique D. Bonnet, Kevin Jack, Yongkui Sun, David J. Mathre, and Robert A. Reamer Proc Natl Acad Sci U S A. 2004 April 13; 101(15): 5379–5384. Published online 2004 March 31. doi: 10.1073/pnas.0306918101.PMCID: PMC397389 Asymmetric hydrogenation of α,β-unsaturated phosphonates with Rh-BisP* and Rh-MiniPHOS catalysts: Scope and mechanism of the reaction Ilya D. Gridnev, Masaya Yasutake, Tsuneo Imamoto, and Irina P. Beletskaya Proc Natl Acad Sci U S A. 2004 April 13; 101(15): 5385–5390. Published online 2004 March 15. doi: 10.1073/pnas.0306993101.PMCID: PMC397390 Asymmetric hetero-Diels–Alder reaction catalyzed by dirhodium(II) carboxamidates Michael P. Doyle, Marcela Valenzuela, and Penglin Huang Proc Natl Acad Sci U S A. 2004 April 13; 101(15): 5391–5395. Published online 2004 April 1. doi: 10.1073/pnas.0307025101.PMCID: PMC397391 An efficient, palladium-catalyzed, enantioselective synthesis of (2R)-3-butene-1,2-diol and its use in highly selective Heck reactions Natasha Cheeseman, Martin Fox, Mark Jackson, Ian C. Lennon, and Graham Meek Proc Natl Acad Sci U S A. 2004 April 13; 101(15): 5396–5399. Published online 2004 February 11. doi: 10.1073/pnas.0307047101.PMCID: PMC397392 OH–Pd(0) interaction as a stabilizing factor in palladium-catalyzed allylic alkylations Kristina Hallman, Anders Frölander, Tebikie Wondimagegn, Mats Svensson, and Christina Moberg Proc Natl Acad Sci U S A. 2004 April 13; 101(15): 5400–5404. Published online 2004 April 5. doi: 10.1073/pnas.0307084101.PMCID: PMC397393 Catalytic asymmetric addition of diorganozinc reagents to N-phosphinoylalkylimines Alexandre Côté, Alessandro A. Boezio, and André B. Charette Proc Natl Acad Sci U S A. 2004 April 13; 101(15): 5405–5410. Published online 2004 April 2. doi: 10.1073/pnas.0307096101.PMCID: PMC397394 New biphenol-based, fine-tunable monodentate phosphoramidite ligands for catalytic asymmetric transformations Zihao Hua, Victor C. Vassar, Hojae Choi, and Iwao Ojima Proc Natl Acad Sci U S A. 2004 April 13; 101(15): 5411–5416. Published online 2004 March 12. doi: 10.1073/pnas.0307101101.PMCID: PMC397395 Highly enantioselective alkyne additions to aldehydes in the presence of 1,1′-bi-2-naphthol and hexamethylphosphoramide Ge Gao, Ru-Gang Xie, and Lin Pu Proc Natl Acad Sci U S A. 2004 April 13; 101(15): 5417–5420. Published online 2004 March 16. doi: 10.1073/pnas.0307136101.PMCID: PMC397396 Desymmetrization of enone-diones via rhodium-catalyzed diastereo- and enantioselective tandem conjugate addition-aldol cyclization Brian M. Bocknack, Long-Cheng Wang, and Michael J. Krische Proc Natl Acad Sci U S A. 2004 April 13; 101(15): 5421–5424. Published online 2004 March 15. doi: 10.1073/pnas.0307120101.PMCID: PMC397397 Catalytic asymmetric addition of diphenylzinc to cyclic α,β-unsaturated ketones Hongmei Li, Celina García, and Patrick J. Walsh Proc Natl Acad Sci U S A. 2004 April 13; 101(15): 5425–5427. Published online 2004 April 5. doi: 10.1073/pnas.0307119101.PMCID: PMC397398 Solid-phase synthesis of chiral 3,4-diazaphospholanes and their application to catalytic asymmetric allylic alkylation Clark R. Landis and Thomas P. Clark Proc Natl Acad Sci U S A. 2004 April 13; 101(15): 5428–5432. Published online 2004 February 25. doi: 10.1073/pnas.0307572100.PMCID: PMC397399 Enantioselective syntheses and biological studies of aeruginosin 298-A and its analogs: Application of catalytic asymmetric phase-transfer reaction Yuhei Fukuta, Takashi Ohshima, Vijay Gnanadesikan, Tomoyuki Shibuguchi, Tetsuhiro Nemoto, Takaya Kisugi, Tatsufumi Okino, and Masakatsu Shibasaki Proc Natl Acad Sci U S A. 2004 April 13; 101(15): 5433–5438. Published online 2004 March 2. doi: 10.1073/pnas.0307154101.PMCID: PMC397400 Chiral phosphoramide-catalyzed, enantioselective, directed cross-aldol reactions of aldehydes Scott E. Denmark and Tommy Bui Proc Natl Acad Sci U S A. 2004 April 13; 101(15): 5439–5444. Published online 2004 April 5. doi: 10.1073/pnas.0307212101.PMCID: PMC397401 Mechanistic studies on the catalytic cycle of rhodium-catalyzed asymmetric 1,4-addition of aryltitanate reagents to α,β-unsaturated ketones Norihito Tokunaga, Kazuhiro Yoshida, and Tamio Hayashi Proc Natl Acad Sci U S A. 2004 April 13; 101(15): 5445–5449. Published online 2004 February 23. doi: 10.1073/pnas.0307260101.PMCID: PMC397402 Catalytic enantioselective intermolecular cycloadditions of 2-diazo-3,6-diketoester-derived carbonyl ylides with alkene dipolarophiles David M. Hodgson, Tobias Brückl, Rebecca Glen, Agnès H. Labande, Deborah A. Selden, Alexander G. Dossetter, and Alison J. Redgrave Proc Natl Acad Sci U S A. 2004 April 13; 101(15): 5450–5454. Published online 2004 March 22. doi: 10.1073/pnas.0307274101.PMCID: PMC397403 Rhodium-catalyzed asymmetric ring opening reactions of oxabicyclic alkenes: Catalyst and substrate studies leading to a mechanistic working model Mark Lautens and Keith Fagnou Proc Natl Acad Sci U S A. 2004 April 13; 101(15): 5455–5460. Published online 2004 April 5. doi: 10.1073/pnas.0307271101.PMCID: PMC397404 Helically chiral polymers: A class of ligands for asymmetric catalysis Michael Reggelin, Sebastian Doerr, Martin Klussmann, Melanie Schultz, and Michael Holbach Proc Natl Acad Sci U S A. 2004 April 13; 101(15): 5461–5466. Published online 2004 March 30. doi: 10.1073/pnas.0307443101.PMCID: PMC397405 Effect of sulfide structure on enantioselectivity in catalytic asymmetric epoxidation of aldehydes: Mechanistic insights and implications Varinder K. Aggarwal, Jonathan Charmant, Leo Dudin, Marina Porcelloni, and Jeffery Richardson Proc Natl Acad Sci U S A. 2004 April 13; 101(15): 5467–5471. Published online 2004 March 19. doi: 10.1073/pnas.0307559101.PMCID: PMC397406 Catalytic asymmetric reactions for organic synthesis: The combined C—H activation/Cope rearrangement Huw M. L. Davies and Qihui Jin Proc Natl Acad Sci U S A. 2004 April 13; 101(15): 5472–5475. Published online 2004 March 15. doi: 10.1073/pnas.0307556101.PMCID: PMC397407 Air-stable, storable, and highly efficient chiral zirconium catalysts for enantioselective Mannich-type, aza Diels–Alder, aldol, and hetero Diels–Alder reactions Shū Kobayashi, Masaharu Ueno, Susumu Saito, Yumiko Mizuki, Haruro Ishitani, and Yasuhiro Yamashita Proc Natl Acad Sci U S A. 2004 April 13; 101(15): 5476–5481. Published online 2004 April 5. doi: 10.1073/pnas.0307870101.PMCID: PMC397408 From the Cover: Asymmetric Catalysis Special Feature Part I: Enantioselective organocatalytic construction of pyrroloindolines by a cascade addition–cyclization strategy: Synthesis of (–)-flustramine B Joel F. Austin, Sung-Gon Kim, Christopher J. Sinz, Wen-Jing Xiao, and David W. C. MacMillan Proc Natl Acad Sci U S A. 2004 April 13; 101(15): 5482–5487. Published online 2004 April 5. doi: 10.1073/pnas.0308177101.PMCID: PMC397409 Photocleavable fluorescent nucleotides for DNA sequencing on a chip constructed by site-specific coupling chemistry Tae Seok Seo, Xiaopeng Bai, Hameer Ruparel, Zengmin Li, Nicholas J. Turro, and Jingyue Ju Proc Natl Acad Sci U S A. 2004 April 13; 101(15): 5488–5493. Published online 2004 April 2. doi: 10.1073/pnas.0401138101.PMCID: PMC397410 From the Cover: The HP-1 maquette: From an apoprotein structure to a structured hemoprotein designed to promote redox-coupled proton exchange Steve S. Huang, Ronald L. Koder, Mitchell Lewis, A. Joshua Wand, and P. Leslie Dutton Proc Natl Acad Sci U S A. 2004 April 13; 101(15): 5536–5541. Published online 2004 March 31. doi: 10.1073/pnas.0306676101.PMCID: PMC397418 Biological Sciences Biochemistry From the Cover: Small interfering RNA production by enzymatic engineering of DNA (SPEED) Biao Luo, Amanda D. Heard, and Harvey F. Lodish Proc Natl Acad Sci U S A. 2004 April 13; 101(15): 5494–5499. Published online 2004 March 15. doi: 10.1073/pnas.0400551101.PMCID: PMC397411 Ubiquitylation of synphilin-1 and α-synuclein by SIAH and its presence in cellular inclusions and Lewy bodies imply a role in Parkinson's disease Esti Liani, Allon Eyal, Eyal Avraham, Revital Shemer, Raymonde Szargel, Daniela Berg, Antje Bornemann, Olaf Riess, Christopher A. Ross, Ruth Rott, and Simone Engelender Proc Natl Acad Sci U S A. 2004 April 13; 101(15): 5500–5505. Published online 2004 April 2. doi: 10.1073/pnas.0401081101.PMCID: PMC397412 Metalloregulation of yeast membrane steroid receptor homologs Thomas J. Lyons, Nancy Y. Villa, Lisa M. Regalla, Brian R. Kupchak, Anna Vagstad, and David J. Eide Proc Natl Acad Sci U S A. 2004 April 13; 101(15): 5506–5511. Published online 2004 April 1. doi: 10.1073/pnas.0306324101.PMCID: PMC397413 Acetylcholinesterase/paraoxonase genotype and expression predict anxiety scores in Health, Risk Factors, Exercise Training, and Genetics study Ella H. Sklan, Alexander Lowenthal, Mira Korner, Ya'acov Ritov, Daniel M. Landers, Tuomo Rankinen, Claude Bouchard, Arthur S. Leon, Treva Rice, D. C. Rao, Jack H. Wilmore, James S. Skinner, and Hermona Soreq Proc Natl Acad Sci U S A. 2004 April 13; 101(15): 5512–5517. Published online 2004 April 1. doi: 10.1073/pnas.0307659101.PMCID: PMC397414 Oxygen and the copper chaperone CCS regulate posttranslational activation of Cu,Zn superoxide dismutase Nina M. Brown, Andrew S. Torres, Peter E. Doan, and Thomas V. O'Halloran Proc Natl Acad Sci U S A. 2004 April 13; 101(15): 5518–5523. Published online 2004 April 2. doi: 10.1073/pnas.0401175101.PMCID: PMC397415 Temporal linkage between the phenotypic and genomic responses to caloric restriction Joseph M. Dhahbi, Hyon-Jeen Kim, Patricia L. Mote, Robert J. Beaver, and Stephen R. Spindler Proc Natl Acad Sci U S A. 2004 April 13; 101(15): 5524–5529. Published online 2004 March 25. doi: 10.1073/pnas.0305300101.PMCID: PMC397416 Biophysics INAUGURAL ARTICLE by a Recently Elected Academy Member: Small potassium ion channel proteins encoded by chlorella viruses Ming Kang, Anna Moroni, Sabrina Gazzarrini, Dario DiFrancesco, Gerhard Thiel, Maria Severino, and James L. Van Etten Proc Natl Acad Sci U S A. 2004 April 13; 101(15): 5318–5324. Published online 2004 February 4. doi: 10.1073/pnas.0307824100.PMCID: PMC397378 Photocleavable fluorescent nucleotides for DNA sequencing on a chip constructed by site-specific coupling chemistry Tae Seok Seo, Xiaopeng Bai, Hameer Ruparel, Zengmin Li, Nicholas J. Turro, and Jingyue Ju Proc Natl Acad Sci U S A. 2004 April 13; 101(15): 5488–5493. Published online 2004 April 2. doi: 10.1073/pnas.0401138101.PMCID: PMC397410 Modulation of energy-dependent quenching of excitons in antennae of higher plants Thomas J. Avenson, Jeffrey A. Cruz, and David M. Kramer Proc Natl Acad Sci U S A. 2004 April 13; 101(15): 5530–5535. Published online 2004 April 2. doi: 10.1073/pnas.0401269101.PMCID: PMC397417 From the Cover: The HP-1 maquette: From an apoprotein structure to a structured hemoprotein designed to promote redox-coupled proton exchange Steve S. Huang, Ronald L. Koder, Mitchell Lewis, A. Joshua Wand, and P. Leslie Dutton Proc Natl Acad Sci U S A. 2004 April 13; 101(15): 5536–5541. Published online 2004 March 31. doi: 10.1073/pnas.0306676101.PMCID: PMC397418 Cell Biology Myosin V processivity: Multiple kinetic pathways for head-to-head coordination Josh E. Baker, Elena B. Krementsova, Guy G. Kennedy, Amy Armstrong, Kathleen M. Trybus, and David M. Warshaw Proc Natl Acad Sci U S A. 2004 April 13; 101(15): 5542–5546. Published online 2004 March 31. doi: 10.1073/pnas.0307247101.PMCID: PMC397419 COMP-Ang1: A designed angiopoietin-1 variant with nonleaky angiogenic activity Chung-Hyun Cho, Richard A. Kammerer, Hyuek Jong Lee, Michel O. Steinmetz, Young Shin Ryu, Sung Ho Lee, Kunio Yasunaga, Kyung-Tae Kim, Injune Kim, Han-Ho Choi, Won Kim, Sung Hyun Kim, Sung Kwang Park, Gyun Min Lee, and Gou Young Koh Proc Natl Acad Sci U S A. 2004 April 13; 101(15): 5547–5552. Published online 2004 April 1. doi: 10.1073/pnas.0307574101.PMCID: PMC397420 Designed angiopoietin-1 variant, COMP-Ang1, protects against radiation-induced endothelial cell apoptosis Chung-Hyun Cho, Richard A. Kammerer, Hyuek Jong Lee, Kunio Yasunaga, Kyung-Tae Kim, Han-Ho Choi, Won Kim, Sung Hyun Kim, Sung Kwang Park, Gyun Min Lee, and Gou Young Koh Proc Natl Acad Sci U S A. 2004 April 13; 101(15): 5553–5558. Published online 2004 April 1. doi: 10.1073/pnas.0307575101.PMCID: PMC397421 RNA interference of achaete–scute homolog 1 in mouse prostate neuroendocrine cells reveals its gene targets and DNA binding sites Yan Hu, Ting Wang, Gary D. Stormo, and Jeffrey I. Gordon Proc Natl Acad Sci U S A. 2004 April 13; 101(15): 5559–5564. Published online 2004 April 1. doi: 10.1073/pnas.0306988101.PMCID: PMC397422 Direct continuities between cisternae at different levels of the Golgi complex in glucose-stimulated mouse islet beta cells Brad J. Marsh, Niels Volkmann, J. Richard McIntosh, and Kathryn E. Howell Proc Natl Acad Sci U S A. 2004 April 13; 101(15): 5565–5570. Published online 2004 April 2. doi: 10.1073/pnas.0401242101.PMCID: PMC397423 Myristoylated Naked2 escorts transforming growth factor α to the basolateral plasma membrane of polarized epithelial cells Cunxi Li, Jeffrey L. Franklin, Ramona Graves-Deal, W. Gray Jerome, Zheng Cao, and Robert J. Coffey Proc Natl Acad Sci U S A. 2004 April 13; 101(15): 5571–5576. Published online 2004 April 2. doi: 10.1073/pnas.0401294101.PMCID: PMC397424 From the Cover: Suppression of nuclear oscillations in Saccharomyces cerevisiae expressing Glu tubulin A. C. Badin-Larçon, C. Boscheron, J. M. Soleilhac, M. Piel, C. Mann, E. Denarier, A. Fourest-Lieuvin, L. Lafanechère, M. Bornens, and D. Job Proc Natl Acad Sci U S A. 2004 April 13; 101(15): 5577–5582. Published online 2004 March 18. doi: 10.1073/pnas.0307917101.PMCID: PMC397425 Interplay between EphB4 on tumor cells and vascular ephrin-B2 regulates tumor growth Nicole K. Noren, Mark Lu, Andrew L. Freeman, Mitchell Koolpe, and Elena B. Pasquale Proc Natl Acad Sci U S A. 2004 April 13; 101(15): 5583–5588. Published online 2004 April 5. doi: 10.1073/pnas.0401381101.PMCID: PMC397426 Evolution Genome-wide comparative analysis of the transposable elements in the related species Arabidopsis thaliana and Brassica oleracea Xiaoyu Zhang and Susan R. Wessler Proc Natl Acad Sci U S A. 2004 April 13; 101(15): 5589–5594. Published online 2004 April 2. doi: 10.1073/pnas.0401243101.PMCID: PMC397431 Maternal investment affects offspring phenotypic plasticity in a viviparous cockroach Glenn L. Holbrook and Coby Schal Proc Natl Acad Sci U S A. 2004 April 13; 101(15): 5595–5597. Published online 2004 April 2. doi: 10.1073/pnas.0400209101.PMCID: PMC397435 Immunology Recognition of single-stranded RNA viruses by Toll-like receptor 7 Jennifer M. Lund, Lena Alexopoulou, Ayuko Sato, Margaret Karow, Niels C. Adams, Nicholas W. Gale, Akiko Iwasaki, and Richard A. Flavell Proc Natl Acad Sci U S A. 2004 April 13; 101(15): 5598–5603. Published online 2004 March 19. doi: 10.1073/pnas.0400937101.PMCID: PMC397437 Inositol (1,4,5) trisphosphate 3 kinase B controls positive selection of T cells and modulates Erk activity Ben G. Wen, Mathew T. Pletcher, Masaki Warashina, Sun Hui Choe, Niusha Ziaee, Tim Wiltshire, Karsten Sauer, and Michael P. Cooke Proc Natl Acad Sci U S A. 2004 April 13; 101(15): 5604–5609. Published online 2004 April 2. doi: 10.1073/pnas.0306907101.PMCID: PMC397439 Selective expression of IL-7 receptor on memory T cells identifies early CD40L-dependent generation of distinct CD8+ memory T cell subsets Katharina M. Huster, Verena Busch, Matthias Schiemann, Kathrin Linkemann, Kristen M. Kerksiek, Hermann Wagner, and Dirk H. Busch Proc Natl Acad Sci U S A. 2004 April 13; 101(15): 5610–5615. Published online 2004 March 25. doi: 10.1073/pnas.0308054101.PMCID: PMC397444 Distinct cell types control lymphoid subset development by means of IL-15 and IL-15 receptor α expression Kimberly S. Schluns, Elizabeth C. Nowak, Arturo Cabrera-Hernandez, Lynn Puddington, Leo Lefrançois, and Hector L. Aguila Proc Natl Acad Sci U S A. 2004 April 13; 101(15): 5616–5621. Published online 2004 April 1. doi: 10.1073/pnas.0307442101.PMCID: PMC397446 Medical Sciences INAUGURAL ARTICLE by a Recently Elected Academy Member: All-trans retinoic acid/As 2O 3 combination yields a high quality remission and survival in newly diagnosed acute promyelocytic leukemia Zhi-Xiang Shen, Zhan-Zhong Shi, Jing Fang, Bai-Wei Gu, Jun-Min Li, Yong-Mei Zhu, Jing-Yi Shi, Pei-Zheng Zheng, Hua Yan, Yuan-Fang Liu, Yu Chen, Yang Shen, Wen Wu, Wei Tang, Samuel Waxman, Hugues de Thé, Zhen-Yi Wang, Sai-Juan Chen, and Zhu Chen Proc Natl Acad Sci U S A. 2004 April 13; 101(15): 5328–5335. Published online 2004 March 24. doi: 10.1073/pnas.0400053101.PMCID: PMC397380 From the Cover: Abrogation of ventricular arrhythmias in a model of ischemia and reperfusion by targeting myocardial calcium cycling Federica del Monte, Djamel Lebeche, J. Luis Guerrero, Tsuyoshi Tsuji, Angelia A. Doye, Judith K. Gwathmey, and Roger J. Hajjar Proc Natl Acad Sci U S A. 2004 April 13; 101(15): 5622–5627. Published online 2004 March 25. doi: 10.1073/pnas.0305778101.PMCID: PMC397450 A target site for template-based design of measles virus entry inhibitors Richard K. Plemper, Karl J. Erlandson, Ami S. Lakdawala, Aiming Sun, Andrew Prussia, Jutatip Boonsombat, Esin Aki-Sener, Ismail Yalcin, Ilkay Yildiz, Ozlem Temiz-Arpaci, Betul Tekiner, Dennis C. Liotta, James P. Snyder, and Richard W. Compans Proc Natl Acad Sci U S A. 2004 April 13; 101(15): 5628–5633. Published online 2004 March 31. doi: 10.1073/pnas.0308520101.PMCID: PMC397452 Canonical pathway of nuclear factor κB activation selectively regulates proinflammatory and prothrombotic responses in human atherosclerosis Claudia Monaco, Evangelos Andreakos, Serafim Kiriakidis, Claudia Mauri, Colin Bicknell, Brian Foxwell, Nicholas Cheshire, Ewa Paleolog, and Marc Feldmann Proc Natl Acad Sci U S A. 2004 April 13; 101(15): 5634–5639. Published online 2004 April 2. doi: 10.1073/pnas.0401060101.PMCID: PMC397455 Microbiology Roles of substrate availability and infection of resting and activated CD4+ T cells in transmission and acute simian immunodeficiency virus infection Zhi-Qiang Zhang, Stephen W. Wietgrefe, Qingsheng Li, Marta Dykhuizen Shore, Lijie Duan, Cavan Reilly, Jeffrey D. Lifson, and Ashley T. Haase Proc Natl Acad Sci U S A. 2004 April 13; 101(15): 5640–5645. Published online 2004 April 2. doi: 10.1073/pnas.0308425101.PMCID: PMC397458 Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes Rekha Seshadri, Garry S. A. Myers, Hervé Tettelin, Jonathan A. Eisen, John F. Heidelberg, Robert J. Dodson, Tanja M. Davidsen, Robert T. DeBoy, Derrick E. Fouts, Dan H. Haft, Jeremy Selengut, Qinghu Ren, Lauren M. Brinkac, Ramana Madupu, Jamie Kolonay, Scott A. Durkin, Sean C. Daugherty, Jyoti Shetty, Alla Shvartsbeyn, Elizabeth Gebregeorgis, Keita Geer, Getahun Tsegaye, Joel Malek, Bola Ayodeji, Sofiya Shatsman, Michael P. McLeod, David Šmajs, Jerrilyn K. Howell, Sangita Pal, Anita Amin, Pankaj Vashisth, Thomas Z. McNeill, Qin Xiang, Erica Sodergren, Ernesto Baca, George M. Weinstock, Steven J. Norris, Claire M. Fraser, and Ian T. Paulsen Proc Natl Acad Sci U S A. 2004 April 13; 101(15): 5646–5651. Published online 2004 April 2. doi: 10.1073/pnas.0307639101.PMCID: PMC397461 A single amino acid substitution in human APOBEC3G antiretroviral enzyme confers resistance to HIV-1 virion infectivity factor-induced depletion Hongzhan Xu, Evguenia S. Svarovskaia, Rebekah Barr, Yijun Zhang, Mohammad A. Khan, Klaus Strebel, and Vinay K. Pathak Proc Natl Acad Sci U S A. 2004 April 13; 101(15): 5652–5657. Published online 2004 March 30. doi: 10.1073/pnas.0400830101.PMCID: PMC397464 Neuroscience INAUGURAL ARTICLE by a Recently Elected Academy Member: PERIOD2::LUCIFERASE real-time reporting of circadian dynamics reveals persistent circadian oscillations in mouse peripheral tissues Seung-Hee Yoo, Shin Yamazaki, Phillip L. Lowrey, Kazuhiro Shimomura, Caroline H. Ko, Ethan D. Buhr, Sandra M. Siepka, Hee-Kyung Hong, Won Jun Oh, Ook Joon Yoo, Michael Menaker, and Joseph S. Takahashi Proc Natl Acad Sci U S A. 2004 April 13; 101(15): 5339–5346. Published online 2004 February 12. doi: 10.1073/pnas.0308709101.PMCID: PMC397382 Beyond sensory images: Object-based representation in the human ventral pathway Pietro Pietrini, Maura L. Furey, Emiliano Ricciardi, M. Ida Gobbini, W.-H. Carolyn Wu, Leonardo Cohen, Mario Guazzelli, and James V. Haxby Proc Natl Acad Sci U S A. 2004 April 13; 101(15): 5658–5663. Published online 2004 April 2. doi: 10.1073/pnas.0400707101.PMCID: PMC397466 A single cocaine exposure enhances both opioid reward and aversion through a ventral tegmental area-dependent mechanism Joseph A. Kim, Kelly A. Pollak, Gregory O. Hjelmstad, and Howard L. Fields Proc Natl Acad Sci U S A. 2004 April 13; 101(15): 5664–5669. Published online 2004 April 2. doi: 10.1073/pnas.0401373101.PMCID: PMC397468 Classification of natural textures in echolocation Jan-Eric Grunwald, Sven Schörnich, and Lutz Wiegrebe Proc Natl Acad Sci U S A. 2004 April 13; 101(15): 5670–5674. Published online 2004 April 1. doi: 10.1073/pnas.0308029101.PMCID: PMC397469 Physiology Cumulative inactivation of N-type CaV2.2 calcium channels modified by alternative splicing Christopher Thaler, Annette C. Gray, and Diane Lipscombe Proc Natl Acad Sci U S A. 2004 April 13; 101(15): 5675–5679. Published online 2004 April 1. doi: 10.1073/pnas.0303402101.PMCID: PMC397472 Plant Biology Induction of oral tolerance to prevent diabetes with transgenic plants requires glutamic acid decarboxylase (GAD) and IL-4 Shengwu Ma, Yan Huang, ZiQin Yin, Rima Menassa, James E. Brandle, and Anthony M. Jevnikar Proc Natl Acad Sci U S A. 2004 April 13; 101(15): 5680–5685. Published online 2004 March 31. doi: 10.1073/pnas.0307420101.PMCID: PMC397475 Psychology The change of the brain activation patterns as children learn algebra equation solving Yulin Qin, Cameron S. Carter, Eli M. Silk, V. Andrew Stenger, Kate Fissell, Adam Goode, and John R. Anderson Proc Natl Acad Sci U S A. 2004 April 13; 101(15): 5686–5691. Published online 2004 April 2. doi: 10.1073/pnas.0401227101.PMCID: PMC397478 Social Sciences Anthropology Kusunda: An Indo-Pacific language in Nepal Paul Whitehouse, Timothy Usher, Merritt Ruhlen, and William S.-Y. Wang Proc Natl Acad Sci U S A. 2004 April 13; 101(15): 5692–5695. Published online 2004 March 31. doi: 10.1073/pnas.0400233101.PMCID: PMC397480 Corrections Proc Natl Acad Sci U S A. 2004 April 13; 101(15): 5696. doi: 10.1073/pnas.0400920101.PMCID: PMC397482 Corrects: Peter A. Cotton. Avian migration phenology and global climate change. Proc Natl Acad Sci U S A. 2003 October 14; 100(21): 12219–12222. Proc Natl Acad Sci U S A. 2004 April 13; 101(15): 5696. doi: 10.1073/pnas.0401592101.PMCID: PMC397484 Corrects: David L. Smith, et al. Persistent colonization and the spread of antibiotic resistance in nosocomial pathogens: Resistance is a regional problem. Proc Natl Acad Sci U S A. 2004 March 9; 101(10): 3709–3714. Proc Natl Acad Sci U S A. 2004 April 13; 101(15): 5696. doi: 10.1073/pnas.0401218101.PMCID: PMC397486 Corrects: Maki Ohgishi, et al. Functional analysis of each blue light receptor, cry1, cry2, phot1, and phot2, by using combinatorial multiple mutants in Arabidopsis. Proc Natl Acad Sci U S A. 2004 February 24; 101(8): 2223–2228. |