| | This journal provides immediate access to some articles. In This Issue Proc Natl Acad Sci U S A. 2005 May 3; 102(18): 6239–6240. doi: 10.1073/iti1805102.PMCID: PMC1088397 Editorial How and why to publish in PNAS Alan Fersht Proc Natl Acad Sci U S A. 2005 May 3; 102(18): 6241–6242. Published online 2005 April 21. doi: 10.1073/pnas.0502713102.PMCID: PMC1088396 Commentary Recruiting dendritic cells to improve antibody therapy of cancer Kavita M. Dhodapkar and Madhav V. Dhodapkar Proc Natl Acad Sci U S A. 2005 May 3; 102(18): 6243–6244. Published online 2005 April 25. doi: 10.1073/pnas.0502547102.PMCID: PMC1088395 Physical Sciences Applied Mathematics A coherent framework for multiresolution analysis of biological networks with “memory”: Ras pathway, cell cycle, and immune system Paolo Emilio Barbano, Marina Spivak, Jiawu Feng, Marco Antoniotti, and Bud Mishra Proc Natl Acad Sci U S A. 2005 May 3; 102(18): 6245–6250. Published online 2005 April 20. doi: 10.1073/pnas.0500554102.PMCID: PMC1088370 Chemistry The question of C- vs. O-silylation of ketenes: Electrophilic triethylsilylation of diphenylketene G. K. Surya Prakash, Chulsung Bae, Golam Rasul, and George A. Olah Proc Natl Acad Sci U S A. 2005 May 3; 102(18): 6251–6254. Published online 2005 April 19. doi: 10.1073/pnas.0501813102.PMCID: PMC1088379 From the Cover: The retinal chromophore/chloride ion pair: Structure of the photoisomerization path and interplay of charge transfer and covalent states Alessandro Cembran, Fernando Bernardi, Massimo Olivucci, and Marco Garavelli Proc Natl Acad Sci U S A. 2005 May 3; 102(18): 6255–6260. Published online 2005 April 26. doi: 10.1073/pnas.0408723102.PMCID: PMC1088357 Applied Mathematics Using independent open-to-closed transitions to simplify aggregated Markov models of ion channel gating kinetics William J. Bruno, Jin Yang, and John E. Pearson Proc Natl Acad Sci U S A. 2005 May 3; 102(18): 6326–6331. Published online 2005 April 20. doi: 10.1073/pnas.0409110102.PMCID: PMC1088360 Biological Sciences From the Cover: The retinal chromophore/chloride ion pair: Structure of the photoisomerization path and interplay of charge transfer and covalent states Alessandro Cembran, Fernando Bernardi, Massimo Olivucci, and Marco Garavelli Proc Natl Acad Sci U S A. 2005 May 3; 102(18): 6255–6260. Published online 2005 April 26. doi: 10.1073/pnas.0408723102.PMCID: PMC1088357 Agricultural Sciences Meat and milk compositions of bovine clones X. Cindy Tian, Chikara Kubota, Kunihito Sakashita, Yoshiaki Izaike, Ryoichi Okano, Norio Tabara, Carol Curchoe, Lavina Jacob, Yuqin Zhang, Sadie Smith, Charles Bormann, Jie Xu, Masumi Sato, Sheila Andrew, and Xiangzhong Yang Proc Natl Acad Sci U S A. 2005 May 3; 102(18): 6261–6266. Published online 2005 April 13. doi: 10.1073/pnas.0500140102.PMCID: PMC1088367 Biochemistry E1A and a nuclear receptor corepressor splice variant (N-CoRI) are thyroid hormone receptor coactivators that bind in the corepressor mode Xianwang Meng, Paul Webb, Yong-Fan Yang, Michael Shuen, Ahmed F. Yousef, John D. Baxter, Joe S. Mymryk, and Paul G. Walfish Proc Natl Acad Sci U S A. 2005 May 3; 102(18): 6267–6272. Published online 2005 April 22. doi: 10.1073/pnas.0501491102.PMCID: PMC1088377 A positive feedback vector for identification of nucleotide sequences that enhance translation Wei Zhou, Gerald M. Edelman, and Vincent P. Mauro Proc Natl Acad Sci U S A. 2005 May 3; 102(18): 6273–6278. Published online 2005 April 21. doi: 10.1073/pnas.0409892102.PMCID: PMC1088366 β-TrCP recognizes a previously undescribed nonphosphorylated destruction motif in Cdc25A and Cdc25B phosphatases Yoshinori Kanemori, Katsuhiro Uto, and Noriyuki Sagata Proc Natl Acad Sci U S A. 2005 May 3; 102(18): 6279–6284. Published online 2005 April 21. doi: 10.1073/pnas.0501873102.PMCID: PMC1083676 Phosphorylation of a UDP-glucuronosyltransferase regulates substrate specificity Nikhil K. Basu, Martina Kovarova, Amanda Garza, Shigeki Kubota, Tapas Saha, Partha S. Mitra, Rajat Banerjee, Juan Rivera, and Ida S. Owens Proc Natl Acad Sci U S A. 2005 May 3; 102(18): 6285–6290. Published online 2005 April 21. doi: 10.1073/pnas.0407872102.PMCID: PMC1088353 Genes required for rapid expression of nitrogenase activity in Azotobacter vinelandii Leonardo Curatti, Carolyn S. Brown, Paul W. Ludden, and Luis M. Rubio Proc Natl Acad Sci U S A. 2005 May 3; 102(18): 6291–6296. Published online 2005 April 21. doi: 10.1073/pnas.0501216102.PMCID: PMC1088376 Raft lipids as common components of human extracellular amyloid fibrils Gerald P. Gellermann, Thomas R. Appel, Astrid Tannert, Anja Radestock, Peter Hortschansky, Volker Schroeckh, Christian Leisner, Tim Lütkepohl, Shmuel Shtrasburg, Christoph Röcken, Mordechai Pras, Reinhold P. Linke, Stephan Diekmann, and Marcus Fändrich Proc Natl Acad Sci U S A. 2005 May 3; 102(18): 6297–6302. Published online 2005 April 25. doi: 10.1073/pnas.0407035102.PMCID: PMC1088351 Biophysics A rhodopsin exhibiting binding ability to agonist all-trans-retinal Hisao Tsukamoto, Akihisa Terakita, and Yoshinori Shichida Proc Natl Acad Sci U S A. 2005 May 3; 102(18): 6303–6308. Published online 2005 April 25. doi: 10.1073/pnas.0500378102.PMCID: PMC1088369 A folding-dependent mechanism of antimicrobial peptide resistance to degradation unveiled by solution structure of distinctin Domenico Raimondo, Giuseppina Andreotti, Nathalie Saint, Pietro Amodeo, Giovanni Renzone, Marina Sanseverino, Ivana Zocchi, Gerard Molle, Andrea Motta, and Andrea Scaloni Proc Natl Acad Sci U S A. 2005 May 3; 102(18): 6309–6314. Published online 2005 April 19. doi: 10.1073/pnas.0409004102.PMCID: PMC1088359 Early events in the folding of four-helix-bundle heme proteins Jasmin Faraone-Mennella, Harry B. Gray, and Jay R. Winkler Proc Natl Acad Sci U S A. 2005 May 3; 102(18): 6315–6319. Published online 2005 April 20. doi: 10.1073/pnas.0502301102.PMCID: PMC1088390 Crosslinking a lipid raft component triggers liquid ordered-liquid disordered phase separation in model plasma membranes A. T. Hammond, F. A. Heberle, T. Baumgart, D. Holowka, B. Baird, and G. W. Feigenson Proc Natl Acad Sci U S A. 2005 May 3; 102(18): 6320–6325. Published online 2005 April 25. doi: 10.1073/pnas.0405654102.PMCID: PMC1088350 Using independent open-to-closed transitions to simplify aggregated Markov models of ion channel gating kinetics William J. Bruno, Jin Yang, and John E. Pearson Proc Natl Acad Sci U S A. 2005 May 3; 102(18): 6326–6331. Published online 2005 April 20. doi: 10.1073/pnas.0409110102.PMCID: PMC1088360 From the Cover: Evaluating putative mechanisms of the mitotic spindle checkpoint Andreas Doncic, Eshel Ben-Jacob, and Naama Barkai Proc Natl Acad Sci U S A. 2005 May 3; 102(18): 6332–6337. Published online 2005 April 25. doi: 10.1073/pnas.0409142102.PMCID: PMC1088361 Cell Biology Localized glucose and water influx facilitates Cryptosporidium parvum cellular invasion by means of modulation of host-cell membrane protrusion Xian-Ming Chen, Steven P. O'Hara, Bing Q. Huang, Patrick L. Splinter, Jeremy B. Nelson, and Nicholas F. LaRusso Proc Natl Acad Sci U S A. 2005 May 3; 102(18): 6338–6343. Published online 2005 April 25. doi: 10.1073/pnas.0408563102.PMCID: PMC1088355 Serine 31 phosphorylation of histone variant H3.3 is specific to regions bordering centromeres in metaphase chromosomes Sandra B. Hake, Benjamin A. Garcia, Monika Kauer, Stephen P. Baker, Jeffrey Shabanowitz, Donald F. Hunt, and C. David Allis Proc Natl Acad Sci U S A. 2005 May 3; 102(18): 6344–6349. Published online 2005 April 25. doi: 10.1073/pnas.0502413102.PMCID: PMC1088391 Capturing protein interactions in the secretory pathway of living cells Beat Nyfeler, Stephen W. Michnick, and Hans-Peter Hauri Proc Natl Acad Sci U S A. 2005 May 3; 102(18): 6350–6355. Published online 2005 April 22. doi: 10.1073/pnas.0501976102.PMCID: PMC1084318 From the Cover: Human lysyl-tRNA synthetase is secreted to trigger proinflammatory response Sang Gyu Park, Hye Jin Kim, You Hong Min, Eung-Chil Choi, Young Kee Shin, Bum-Joon Park, Sang Won Lee, and Sunghoon Kim Proc Natl Acad Sci U S A. 2005 May 3; 102(18): 6356–6361. Published online 2005 April 25. doi: 10.1073/pnas.0500226102.PMCID: PMC1088368 Tetanus neurotoxin-mediated cleavage of cellubrevin impairs epithelial cell migration and integrin-dependent cell adhesion Véronique Proux-Gillardeaux, Julie Gavard, Theano Irinopoulou, René-Marc Mège, and Thierry Galli Proc Natl Acad Sci U S A. 2005 May 3; 102(18): 6362–6367. Published online 2005 April 25. doi: 10.1073/pnas.0409613102.PMCID: PMC1088364 Synonymous mutations in CFTR exon 12 affect splicing and are not neutral in evolution Franco Pagani, Michela Raponi, and Francisco E. Baralle Proc Natl Acad Sci U S A. 2005 May 3; 102(18): 6368–6372. Published online 2005 April 19. doi: 10.1073/pnas.0502288102.PMCID: PMC1088389 Developmental Biology roundabout4 is essential for angiogenesis in vivo Victoria M. Bedell, Sang-Yeob Yeo, Kye Won Park, Jeffrey Chung, Pankaj Seth, Venkatesha Shivalingappa, Jinhua Zhao, Tomoko Obara, Vikas P. Sukhatme, Iain A. Drummond, Dean Y. Li, and Ramani Ramchandran Proc Natl Acad Sci U S A. 2005 May 3; 102(18): 6373–6378. Published online 2005 April 22. doi: 10.1073/pnas.0408318102.PMCID: PMC1088354 Evolution Rapid electrostatic evolution at the binding site for cytochrome c on cytochrome c oxidase in anthropoid primates Timothy R. Schmidt, Derek E. Wildman, Monica Uddin, Juan C. Opazo, Morris Goodman, and Lawrence I. Grossman Proc Natl Acad Sci U S A. 2005 May 3; 102(18): 6379–6384. Published online 2005 April 25. doi: 10.1073/pnas.0409714102.PMCID: PMC1088365 Evolutionary origin of cAMP-based chemoattraction in the social amoebae Elisa Alvarez-Curto, Daniel E. Rozen, Allyson V. Ritchie, Celine Fouquet, Sandra L. Baldauf, and Pauline Schaap Proc Natl Acad Sci U S A. 2005 May 3; 102(18): 6385–6390. Published online 2005 April 25. doi: 10.1073/pnas.0502238102.PMCID: PMC1088387 Differences in color vision make passerines less conspicuous in the eyes of their predators Olle Håstad, Jonas Victorsson, and Anders Ödeen Proc Natl Acad Sci U S A. 2005 May 3; 102(18): 6391–6394. Published online 2005 April 25. doi: 10.1073/pnas.0409228102.PMCID: PMC1088363 Solving the protein sequence metric problem William R. Atchley, Jieping Zhao, Andrew D. Fernandes, and Tanja Drüke Proc Natl Acad Sci U S A. 2005 May 3; 102(18): 6395–6400. Published online 2005 April 25. doi: 10.1073/pnas.0408677102.PMCID: PMC1088356 Sequence signatures and the probabilistic identification of proteins in the Myc-Max-Mad network William R. Atchley and Andrew D. Fernandes Proc Natl Acad Sci U S A. 2005 May 3; 102(18): 6401–6406. Published online 2005 April 25. doi: 10.1073/pnas.0408964102.PMCID: PMC1088358 Genetics A specific subdomain in 29 DNA polymerase confers both processivity and strand-displacement capacity Irene Rodríguez, José M. Lázaro, Luis Blanco, Satwik Kamtekar, Andrea J. Berman, Jimin Wang, Thomas A. Steitz, Margarita Salas, and Miguel de Vega Proc Natl Acad Sci U S A. 2005 May 3; 102(18): 6407–6412. Published online 2005 April 21. doi: 10.1073/pnas.0500597102.PMCID: PMC1088371 Transgenic engineering of male-specific muscular hypertrophy Dimitri Pirottin, Luc Grobet, Antoine Adamantidis, Frédéric Farnir, Christian Herens, Henrik Daa Schrøder, and Michel Georges Proc Natl Acad Sci U S A. 2005 May 3; 102(18): 6413–6418. Published online 2005 April 25. doi: 10.1073/pnas.0502426102.PMCID: PMC1088392 Temporal profile of replication of human chromosomes Yesu Jeon, Stefan Bekiranov, Neerja Karnani, Philipp Kapranov, Srinka Ghosh, David MacAlpine, Charles Lee, Deog Su Hwang, Thomas R. Gingeras, and Anindya Dutta Proc Natl Acad Sci U S A. 2005 May 3; 102(18): 6419–6424. Published online 2005 April 21. doi: 10.1073/pnas.0405088102.PMCID: PMC1088349 Mutagenesis by reversible promoter insertion to study the activation of NF-κB Eugene S. Kandel, Tao Lu, Youzhong Wan, Mukesh K. Agarwal, Mark W. Jackson, and George R. Stark Proc Natl Acad Sci U S A. 2005 May 3; 102(18): 6425–6430. Published online 2005 April 25. doi: 10.1073/pnas.0502463102.PMCID: PMC1088393 Functionally distinct polymorphic sequences in the human genome that are targets for p53 transactivation Daniel J. Tomso, Alberto Inga, Daniel Menendez, Gary S. Pittman, Michelle R. Campbell, Francesca Storici, Douglas A. Bell, and Michael A. Resnick Proc Natl Acad Sci U S A. 2005 May 3; 102(18): 6431–6436. Published online 2005 April 20. doi: 10.1073/pnas.0501721102.PMCID: PMC1088378 Immunology Distinct role of lymphocyte function-associated antigen-1 in mediating effective cytolytic activity by cytotoxic T lymphocytes Nadia Anikeeva, Kristina Somersalo, Tasha N. Sims, V. Kaye Thomas, Michael L. Dustin, and Yuri Sykulev Proc Natl Acad Sci U S A. 2005 May 3; 102(18): 6437–6442. Published online 2005 April 25. doi: 10.1073/pnas.0502467102.PMCID: PMC1088394 A point mutation in the groove of HLA-DO allows egress from the endoplasmic reticulum independent of HLA-DM Francis Deshaies, Alexandre Brunet, Djibril A. Diallo, Lisa K. Denzin, Angela Samaan, and Jacques Thibodeau Proc Natl Acad Sci U S A. 2005 May 3; 102(18): 6443–6448. Published online 2005 April 22. doi: 10.1073/pnas.0500853102.PMCID: PMC1088373 Induction of CD4+CD25+ regulatory T cells by copolymer-I through activation of transcription factor Foxp3 Jian Hong, Ningli Li, Xuejun Zhang, Biao Zheng, and Jingwu Z. Zhang Proc Natl Acad Sci U S A. 2005 May 3; 102(18): 6449–6454. Published online 2005 April 25. doi: 10.1073/pnas.0502187102.PMCID: PMC1088385 Ligand-induced dimerization of Drosophila peptidoglycan recognition proteins in vitro Peter Mellroth, Jenny Karlsson, Janet Håkansson, Niklas Schultz, William E. Goldman, and Håkan Steiner Proc Natl Acad Sci U S A. 2005 May 3; 102(18): 6455–6460. Published online 2005 April 20. doi: 10.1073/pnas.0407559102.PMCID: PMC1088352 From the Cover: Efficient cross-priming of tumor antigen-specific T cells by dendritic cells sensitized with diverse anti-MICA opsonized tumor cells Veronika Groh, Yongqing Q. Li, Daniel Cioca, Naomi N. Hunder, Wei Wang, Stanley R. Riddell, Cassian Yee, and Thomas Spies Proc Natl Acad Sci U S A. 2005 May 3; 102(18): 6461–6466. Published online 2005 April 11. doi: 10.1073/pnas.0501953102.PMCID: PMC1088382 Mast cells enhance T cell activation: Importance of mast cell-derived TNF Susumu Nakae, Hajime Suto, Maki Kakurai, Jonathon D. Sedgwick, Mindy Tsai, and Stephen J. Galli Proc Natl Acad Sci U S A. 2005 May 3; 102(18): 6467–6472. Published online 2005 April 19. doi: 10.1073/pnas.0501912102.PMCID: PMC1088381 Medical Sciences In vivo fragmentation of heparan sulfate by heparanase overexpression renders mice resistant to amyloid protein A amyloidosis Jin-Ping Li, Martha L. Escobar Galvis, Feng Gong, Xiao Zhang, Eyal Zcharia, Shula Metzger, Israel Vlodavsky, Robert Kisilevsky, and Ulf Lindahl Proc Natl Acad Sci U S A. 2005 May 3; 102(18): 6473–6477. Published online 2005 April 20. doi: 10.1073/pnas.0502287102.PMCID: PMC1088388 Microbiology From the Cover: Massive nitrogen loss from the Benguela upwelling system through anaerobic ammonium oxidation Marcel M. M. Kuypers, Gaute Lavik, Dagmar Woebken, Markus Schmid, Bernhard M. Fuchs, Rudolf Amann, Bo Barker Jørgensen, and Mike S. M. Jetten Proc Natl Acad Sci U S A. 2005 May 3; 102(18): 6478–6483. Published online 2005 April 20. doi: 10.1073/pnas.0502088102.PMCID: PMC556276 Nanoscale visualization and characterization of Myxococcus xanthus cells with atomic force microscopy Andrew E. Pelling, Yinuo Li, Wenyuan Shi, and James K. Gimzewski Proc Natl Acad Sci U S A. 2005 May 3; 102(18): 6484–6489. Published online 2005 April 19. doi: 10.1073/pnas.0501207102.PMCID: PMC1088375 Varicella-zoster virus infection of human dorsal root ganglia in vivo Leigh Zerboni, Chia-Chi Ku, Carol D. Jones, James L. Zehnder, and Ann M. Arvin Proc Natl Acad Sci U S A. 2005 May 3; 102(18): 6490–6495. Published online 2005 April 25. doi: 10.1073/pnas.0501045102.PMCID: PMC1088374 The Pseudomonas syringae effector AvrRpt2 cleaves its C-terminally acylated target, RIN4, from Arabidopsis membranes to block RPM1 activation Han-Suk Kim, Darrell Desveaux, Alex U. Singer, Priyesh Patel, John Sondek, and Jeffery L. Dangl Proc Natl Acad Sci U S A. 2005 May 3; 102(18): 6496–6501. Published online 2005 April 21. doi: 10.1073/pnas.0500792102.PMCID: PMC1088372 A transcriptional response to singlet oxygen, a toxic byproduct of photosynthesis Jennifer R. Anthony, Kristin L. Warczak, and Timothy J. Donohue Proc Natl Acad Sci U S A. 2005 May 3; 102(18): 6502–6507. Published online 2005 April 26. doi: 10.1073/pnas.0502225102.PMCID: PMC1088386 Psychology Positive affect and health-related neuroendocrine, cardiovascular, and inflammatory processes Andrew Steptoe, Jane Wardle, and Michael Marmot Proc Natl Acad Sci U S A. 2005 May 3; 102(18): 6508–6512. Published online 2005 April 19. doi: 10.1073/pnas.0409174102.PMCID: PMC1088362 Correction Proc Natl Acad Sci U S A. 2005 May 3; 102(18): 6513. Published online 2005 April 18. doi: 10.1073/pnas.0500811102.PMCID: PMC1088417 Corrects: Elizabeth J. Renaud, et al. Endometrial cancer is a receptor-mediated target for Mullerian Inhibiting Substance. Proc Natl Acad Sci U S A. 2005 January 4; 102(1): 111–116. |