Cancer Control Research
3R01CA068099-04S1
Ahnen, Dennis J.
INTERGROUP CPRU--FDR SCREENING 3 COLORECTAL CA++ SITES
AbstractThis proposal is one of 3 interactive R0I applications being submitted
in response to RFA CA-94-009: Collaborative Cancer Prevention Research
Units. The overall goal of the proposed CPRU is to design, implement, and
evaluate a standardized, telephone-based, education and counseling
intervention to promote appropriate cancer screening practices among
first degree relatives of cancer patients. This component of the CPRU
application targets colorectal cancer screening among age-eligible
(greater than 40 years old) first degree relatives of colorectal cancer
patients. The specific aims of the proposal are 1. to finalize the design
of a theory-driven (Transtheoretical Model of Behavioral Change, the
Health Beliefs Model and the Transactional Model of Stress), telephone-
based, counseling/educational intervention combined with a reinforcement
mailout; 2. to validate a colorectal cancer screening self-report
instrument in a pilot case-control study; 3. to pilot test the
intervention in 2 Denver-based medical centers; 4. to implement the
revised intervention by identification of patients with colon cancer
within 10 participating centers affiliated with 3 of the largest clinical
cooperative groups in the U.S. (ECOG, SWOG and NCCTG); the telephone
interviews and the intervention in the first degree relatives will be
performed by a team of highly trained telephone counselors from a
Telephone Counseling and Survey Methods Shared Resource of the CPRU; 5.
to evaluate the intervention using a randomized 2- group design
(intervention vs control) with the family unit as the unit of
randomization and a 3 month and 1-year follow up to assess both short-
term (changes in health beliefs, psychologic impact) and long-term
outcomes (rates of colorectal cancer screening); and 6. to conduct
comparative analyses, using a Data Management and Biostastistical Shared
Resource, across all components of the CPRU to assess the
generalizability of the intervention across cancer sites, screening
modalities and gender.
This CPRU application with its cadre of investigators and its network of
participating SWOG , ECOG, and NCCTG centers also forms the
infrastructure for a powerful ongoing program of Cancer Prevention and
Control Research.
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