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Investigator(s):
William L. Dahut, M.D. Principal Investigator Phone: 301-435-8183 dahutw@mail.nih.gov
Referral Contact(s):
Laura D. Otten, R.N., B.S.N., O.C.N. Medical Oncology Referral Coordinator Phone: 301-451-1228 1-866-611-6310 (Toll Free) Fax: 301-480-0919 ottenl@mail.nih.gov	Lea Latham, R.N., B.S.N. Research Nurse Phone: 301-402-9137 llatham@mail.nih.gov

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Primary Eligibility:

• Metastatic androgen independent prostate cancer
• Progressive disease, either radiographically or rising PSA
• No prior chemotherapy for metastatic prostate cancer
• Systolic blood pressure < 170 mmHg and diastolic blood pressure < 100 mmHg
• No proteinuria, defined as a 24-hour urine protein excretion < 300 mg
• No brain metastases
• Age 18 and over
• ECOG 0-2
• Life expectancy of greater than 3 months

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Treatment Plan:

• 21-day cycles during which patients receive:
  • D1 docetaxel
  • D1 bevacizumab
  • Daily oral thalidomide
  • Daily oral prednisone
• Study participants will be placed on prophylactic anticoagulation
• Study participants will be seen every 3 weeks at the National Cancer Institute

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Additional Information:

• This trial will be conducted at the NIH Clinical Center in Bethesda, MD. It is open to patients who meet the eligibility requirements, regardless of where they live in the United States.
• There is no charge for medical care received at NIH Clinical Center.
• FAQs about this study - provides information for patients about the trial such as frequency and duration of visits, costs, how to enroll, treatment plan.
• PDQ (Physicians Data Query) - provides additional details about this study for health care providers.

Reviewed: 
Updated: 1/16/09