Coordination vs. Pressure in Oesophageal Peristalsis

This study is not yet open for participant recruitment.

Verified by Guy's and St Thomas' NHS Foundation Trust, March 2007

Sponsored by:	Guy's and St Thomas' NHS Foundation Trust
Information provided by:	Guy's and St Thomas' NHS Foundation Trust
ClinicalTrials.gov Identifier:	NCT00482885

Purpose

High Resolution Manometry (HRM) is a new advance in oesophageal measurement that permits the acquisition of pressure data through the entire length of the oesophagus over time via closely spaced sensors that continuously record the motor activity of the oesophagus. This allows not only contractile pressure to be measured, but also the coordination (proximal-distal) of contractions and the development of effective intra-bolus pressure (the force that drives bolus movement).

The study hypothesis is that (1) there will be a progressive increase in peristaltic pressure and decrease in velocity as the subjects move from the upright, through the supine to the upside down position and (2) the increase in pressure will be most evident in the mid-oesophagus at the transition zone between the striated and the smooth muscle contractions.

Condition
Esophageal Function

MedlinePlus related topics: Esophagus Disorders

U.S. FDA Resources

Study Type:	Observational
Study Design:	Natural History, Cross-Sectional, Defined Population, Prospective Study
Official Title:	The Effect of Position on Oesophageal Peristalsis and LOS Pressures: a High Resolution Manometry Study

Further study details as provided by Guy's and St Thomas' NHS Foundation Trust:

Study Start Date:	June 2007
Estimated Study Completion Date:	November 2007

Show Detailed Description

Eligibility

Ages Eligible for Study:	18 Years to 70 Years
Genders Eligible for Study:	Both
Accepts Healthy Volunteers:	Yes

Criteria

Inclusion Criteria:

male or female
at least 18 years of age
have given informed consent for the HRM procedure

Exclusion Criteria:

with symptoms or a history of oesophageal gastrointestinal disease
with regular intake of medication. Occasional use of analgesic (e.g. aspirin) is allowed
with any hematological abnormalities
with any evidence of infectious disease
who are pregnant or breast-feeding.
who are fertile women not currently using or complying with a medically approved method of contraception
with evidence or history of drug or alcohol abuse within the past two years
with diabetes mellitus
with mental impairment limiting the ability to comply with study requirements
who are taking or planning to take other investigational drugs during the study
with use of medications influencing upper GI motility within one week of the study (i.e. calcium channel blockers, prokinetic drugs, macrolide antibiotics).
with use of PPIs and H2 blockers

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00482885

Contacts

Contact: Rami Sweis, BM BCh

+44 2071884194

rami.sweis@gmail.com

Sponsors and Collaborators

Guy's and St Thomas' NHS Foundation Trust

Investigators

Principal Investigator:

Mark Fox, MD

Honorary Consultant and Senior Lecturer

More Information

Study ID Numbers:	07/Q0702/3
Study First Received:	June 1, 2007
Last Updated:	June 1, 2007
ClinicalTrials.gov Identifier:	NCT00482885
Health Authority:	United Kingdom: Research Ethics Committee

Keywords provided by Guy's and St Thomas' NHS Foundation Trust:

Esophagus
Peristalsis
Contractile Pressure
Coordination of contraction
Bolus transport

Study placed in the following topic categories:

Digestive System Diseases
Esophageal disorder
Gastrointestinal Diseases
Esophageal Diseases

ClinicalTrials.gov processed this record on January 14, 2009