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#932Principles of Pharmacokinetic Data Analysis: Modeling and Simulation
 
Description:
This workshop will introduce participants to the principles and practice of computerized analysis of pharmacokinetic data. Participants will acquire hands-on experience with the SAAM II Program, an enhanced version of the SAAM Program developed at NIH by Berman and Weiss. The workshop sessions are designed to illustrate both the experimental design and actual analysis of data generated by Phase I, bioavailability and pharmacodynamic/pharmacokinetic (PK/PD) studies, as well as the heuristic use of simulations to explore dose-regimen dependency of a nephrotoxic reaction.
 
Objectives:
Topics to be covered include:
  • principles of model development and testing
  • creation of compartmental models with SAAM II
  • data analysis with one, two and three-compartment models
  • simultaneous analysis of plasma and urine data
  • analysis of bioavailability studies, including flip-flop kinetics
  • analysis of data from pharmacokinetic/pharmacodynamic studies
  • heuristic use of simulations
Who should attend:
NIH fellows and staff who are familiar with basic pharmacokinetic principles, either through taking the "Principles of Clinical Pharmacology" course offered at NIH (see: https://webarchive.library.unt.edu/eot2008/20090130202816/http://www.cc.nih.gov/training/training/principles.html) or through actual work experience. Registration is limited to 20 participants and requires prior approval of Dr. Juan J.L. Lertora (Director, Clinical Pharmacology Program, NIH Clinical Center). Please feel free to call Dr. Lertora at 301-496-9425 to discuss.
 
Instructor(s):
Arthur J. Atkinson, Jr., M.D, Adjunct Professor of Molecular Pharmacology&Biochemistry, Northwestern University
Paolo Vicini, Ph.D, Associate Professor of Bioengineering&David M. Foster, Ph.D, Research Professor Emeritus, University of Washington
 
Time Required:
15 hours
 
Sections Available:
-- Concluded -- 932-09F October 27 - 28 8:30 - 5:00 Building 12A, Room B51
 
NOTE: Although this course has already taken place, we'll put you on a waiting list for the next available session.

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