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NIH has site-wide license. To start your analysis, please visit https://webarchive.library.unt.edu/eot2008/20090130201933/http://helixweb.nih.gov/biobase. Email staff@helix.nih.gov for questions.
Features:- The Explain Analysis System is a web-based, gene regulation-focused, systems biology E-tool that promotes biological interpretation of high throughput experiments like microarrays, proteomic data, and ChIP-chip experiments.
- Identification of key molecules upstream of TFs (kinases, adaptor proteins, receptors) that might be responsible for the coordinated regulation of the suggested TFs
- Mapping of putative transcription factor (TF) binding sites on promoters in focus
- Construction of promoter modules as combinations of individual binding sites and composite regulatory elements, thus suggesting TFs providing common regulation of differentially expressed genes
- Functional classification according to GO terms, diseases terms, tissue/organ expression, and signaling pathways
- The step-by-step workflow allows systematic creation of experimentally testable hypothesis for both gene transcription regulation and signaling networks
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