Inclusion Criteria:

• Patient is informed of the investigational nature of this study and has given written, witnessed informed consent in accordance with institutional, local, and national guidelines
• Males or females ≥ 18 and ≤ 80 years of age; pre-menopausal females (with the exception of those who are surgically sterile) must have a negative pregnancy test at screening; those who are sexually active must practice a highly effective method of birth control for at least 2 weeks prior to study start, and must be willing to continue practicing birth control for at least 4 weeks after the last dose of study drug. A highly effective method of birth control is defined as one that results in a low failure rate (i.e., less than 1% per year) when used consistently and correctly such as implants, injectables, combined oral contraceptives, some IUDs, sexual abstinence (only acceptable if practiced as a life-style and not acceptable if one who is sexually active practices abstinence only for the duration of study) or vasectomized partner
• Patients with histologically confirmed solid tumor malignancy or lymphoma who are scheduled to receive at least 9 weeks of cyclic myelosuppressive chemotherapy while on study
• Hemoglobin value of ≥ 8 and < 11 g/dL within 1 week prior to administration of study drug.*
• ECOG Performance Status of 0-2
• One reticulocyte hemoglobin content (CHr) > 29 pg within 4 weeks prior to study drug administration.*
• One transferrin saturation ≥ 15% within 4 weeks prior to study drug administration.*
• One serum or red cell folate level above the lower limit of normal within 4 weeks prior to study drug administration
• One vitamin B12 level above the lower limit of normal within 4 weeks prior to study drug administration
• One absolute neutrophil count ≥ 1.0 x 10^9/L within 1 week prior to administration of study drug
• One platelet count ≥ 75 x 10^9/L within 1 week prior to administration of study drug
• Life expectancy > 6 months.

If the patient is considered by the Investigator as iron-deficient and IV iron supplementation is required, patient must be re-screened weekly (no sooner than 7 days after iron administration) until hemoglobin has not increased more than 0.5 g/dL from the previous week.*

Exclusion Criteria:

• Treatment with any erythropoiesis stimulating agent (ESA) in the past 90 days
• History of failure to respond to ESA treatment
• Known antibodies to other ESAs or history of pure red cell aplasia (PRCA)
• Acute or chronic leukemia, myelodysplastic syndrome (MDS), or multiple myeloma
• Any previous or planned radiotherapy to more than 50% of either the pelvis or spine
• Known intolerance to parenteral iron supplementation
• RBC transfusion within 4 weeks prior to study drug administration
• Known hemoglobinopathy (e.g., homozygous sickle-cell disease, thalassemia of all types, etc.)
• Known hemolysis
• History of pulmonary embolism or DVT in the previous 2 years or current therapeutic doses of anticoagulants
• Known blood loss as a cause of anemia
• Uncontrolled, or symptomatic inflammatory disease (e.g., rheumatoid arthritis, systemic lupus erythematosus, etc.)
• AST or ALT > 2.5 times the upper limit of normal; AST or ALT > 5 times the upper limit of normal if liver metastases are present.
• Creatinine > 175 µmol/L
• History of bone marrow or peripheral blood cell transplantation
• Pyrexia/fever of ≥ 39 °C within 48 hours prior to study drug administration
• Poorly controlled hypertension, per the Investigator's judgment, within 4 weeks prior to study drug administration (e.g., systolic ≥ 170 mm Hg or diastolic ≥ 100 mm Hg on repeat readings)
• Epileptic seizure in the 6 months prior to study drug administration
• Advanced chronic congestive heart failure - New York Heart Association Class IV
• High likelihood of early withdrawal or interruption of the study (e.g., myocardial infarction within the past 3 months; severe or unstable coronary artery disease; stroke; respiratory, autoimmune, neuropsychiatric or neurological abnormalities; liver disease including active hepatitis B or C; active HIV disease; or any other clinically significant medical diseases or conditions within the prior 6 months that may, in the Investigator's opinion, interfere with assessment or follow-up of the patient)
• Anticipated elective surgery during the study period
• History of multiple drug allergies
• Exposure to any investigational agent within 1 month prior to administration of study drug or planned receipt during the study period.