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Dr. Yan Zhang is a MR Physicist in the MRS Core Facility, National Institute of Mental Health in Bethesda, Maryland. He received his Ph.D. degree in Radio Physics in 2000 from Wuhan Institute of Physics and Mathematics, Chinese Academy of Sciences, Wuhan, China and did post-doctoral training in Memorial Sloan-Kettering Cancer Center in New York and then in the Department of Radiology of the University of Pennsylvania, Philadelphia until he joined NIHM.
Research Interests
Dr. Zhang�s responsibility at the NIMH is focused on the MR pulse sequence development to measure brain metabolites and neurotransmitters such as glutamate/glutamine, GABA and etc. GABA, the major inhibitory neurotransmitter in brain, and glutathione, an important marker of oxidative stress and aging, are overlapped by other intense metabolites such as creatine. Spectral editing techniques are needed to reveal GABA and glutathione in proton spectra. He also develops carbon-13 in vivo spectroscopy on both human and primate MR systems.
Representative Selected Recent Publications
- Yan Zhang, Hee Kwon Song, Jiong J Wang, and Felix Wehrli. Spatially Confined Arterial Spin Labeling with FAIR, J. Magn Reson Imaging. 2005;22;119-124.
- Jiong J Wang, Yan Zhang, Ronald L. Wolf, et al. Amplitude Modulated Continuous Arterial Spin Labeling 3.0-T Perfusion MR Imaging with a Single Coil: Feasibility Study. Radiology. 2005; 235:218-228.
- Yan Zhang, Felix Wehrli, Non-Linear Self-Reference Correction of Nyquist Ghost Artifacts in Echo-Planar Imaging of Human Brain, Magn. Reson. Med. 2004;51:621-624.
- Yan Zhang , Feng Deng, Jianqing Qiu, Chaohui Ye, Spin Locking Mechanism of Spin=3/2 Quadrupolar Nuclei Undergo Magic Angle Spinning, Solid State NMR. 2000; 15: 209-216.
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